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Conserved domains on  [gi|1938922020|ref|XP_007995204|]
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LOW QUALITY PROTEIN: testis-expressed protein 101 [Chlorocebus sabaeus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_TEX101_rpt1 cd23622
first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar ...
 75-173 2.82e-63

first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


:

Pssm-ID: 467142  Cd Length: 99  Bit Score: 194.49  E-value: 2.82e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938922020  75 LYCQKSLSMTVEADPANMFNWTTEEVETCDKGALCQETVLMIKAGTETAILAMKGCIPDGEEAITIVQHSPHPGLIAISY 154
Cdd:cd23622     1 LYCHKGISMTIEEDPRNTFNWTTEKVETCDNGTLCQETILMIKAGTKTAILATKGCISEGMEAVTFIQHTPPPGLVAVSY 80

                          90
                  ....*....|....*....
gi 1938922020 155 SNYCEDSFCNDKDSLSQFW 173
Cdd:cd23622    81 SNYCEDSLCNNKKSLSSFW 99
TFP_LU_ECD_TEX101_rpt2 cd23634
second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar ...
 185-267 5.16e-42

second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of TEX101.


:

Pssm-ID: 467798  Cd Length: 83  Bit Score: 139.82  E-value: 5.16e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938922020 185 TTLHCPTCVALGTCFNAPSLLCPNGTTRCYQGKLEITGGGIESSVEVKGCTATIGCRLMFGILAVGPMFVREVCPRQLLT 264
Cdd:cd23634     1 TTLHCPTCVALGSCFSAPSLPCPRGTTRCYQGRIQLTGGGISSDVEVKGCTTMIGCRLLGGIQTIGPIEVSEKCPRQSFL 80


                  ...
gi 1938922020 265 QPR 267
Cdd:cd23634    81 QPR 83
 
Name Accession Description Interval E-value
TFP_LU_ECD_TEX101_rpt1 cd23622
first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar ...
 75-173 2.82e-63

first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467142  Cd Length: 99  Bit Score: 194.49  E-value: 2.82e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938922020  75 LYCQKSLSMTVEADPANMFNWTTEEVETCDKGALCQETVLMIKAGTETAILAMKGCIPDGEEAITIVQHSPHPGLIAISY 154
Cdd:cd23622     1 LYCHKGISMTIEEDPRNTFNWTTEKVETCDNGTLCQETILMIKAGTKTAILATKGCISEGMEAVTFIQHTPPPGLVAVSY 80

                          90
                  ....*....|....*....
gi 1938922020 155 SNYCEDSFCNDKDSLSQFW 173
Cdd:cd23622    81 SNYCEDSLCNNKKSLSSFW 99
TFP_LU_ECD_TEX101_rpt2 cd23634
second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar ...
 185-267 5.16e-42

second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of TEX101.


Pssm-ID: 467798  Cd Length: 83  Bit Score: 139.82  E-value: 5.16e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938922020 185 TTLHCPTCVALGTCFNAPSLLCPNGTTRCYQGKLEITGGGIESSVEVKGCTATIGCRLMFGILAVGPMFVREVCPRQLLT 264
Cdd:cd23634     1 TTLHCPTCVALGSCFSAPSLPCPRGTTRCYQGRIQLTGGGISSDVEVKGCTTMIGCRLLGGIQTIGPIEVSEKCPRQSFL 80


                  ...
gi 1938922020 265 QPR 267
Cdd:cd23634    81 QPR 83
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 189-258 1.20e-04

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 39.83  E-value: 1.20e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938922020 189 CPTCVALGTCFNAPSLLCPNGTTRCYQGKLEITGGGIESSVEVKGCTATIGCRLMFGILAVGPMFVREVC 258
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCARSSCPRLLSDFINGGIISVSESC 70
 
Name Accession Description Interval E-value
TFP_LU_ECD_TEX101_rpt1 cd23622
first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar ...
 75-173 2.82e-63

first extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467142  Cd Length: 99  Bit Score: 194.49  E-value: 2.82e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938922020  75 LYCQKSLSMTVEADPANMFNWTTEEVETCDKGALCQETVLMIKAGTETAILAMKGCIPDGEEAITIVQHSPHPGLIAISY 154
Cdd:cd23622     1 LYCHKGISMTIEEDPRNTFNWTTEKVETCDNGTLCQETILMIKAGTKTAILATKGCISEGMEAVTFIQHTPPPGLVAVSY 80

                          90
                  ....*....|....*....
gi 1938922020 155 SNYCEDSFCNDKDSLSQFW 173
Cdd:cd23622    81 SNYCEDSLCNNKKSLSSFW 99
TFP_LU_ECD_LYPD4_rpt1_like cd23564
first extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4) ...
 75-173 1.76e-42

first extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4)-like family; The LYPD4-like family includes LYPD4, testis-expressed protein 101 (TEX101), and CD177 antigen. LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. TEX101 (also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG)) is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testis and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. LYPD4 and TEX101 contain two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD. CD177 contains four ECD domains. This model corresponds to the first ECD domain of LYPD4 and TEX101, as well as first and third ECD domains of CD177.


Pssm-ID: 467094  Cd Length: 99  Bit Score: 141.42  E-value: 1.76e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938922020  75 LYCQKSLSMTVEADPANMFNWTTEEVETCDKGALCQETVLMIKAGTETAILAMKGCIPDGEEAITIVQHSPHPGLIAISY 154
Cdd:cd23564     1 LTCYRGTSLYVGANLANEPNWTTSRNETCEAGEVCQETLLLIESGTQVLILGSKGCTPAGSQSSRVTEHVSPPGLIITSY 80

                          90
                  ....*....|....*....
gi 1938922020 155 SNYCEDSFCNDKDSLSQFW 173
Cdd:cd23564    81 TRVCNSDFCNNLSSTSPFL 99
TFP_LU_ECD_TEX101_rpt2 cd23634
second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar ...
 185-267 5.16e-42

second extracellular domain (ECD) found in testis-expressed protein 101 (TEX101) and similar proteins; TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. TEX101 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of TEX101.


Pssm-ID: 467798  Cd Length: 83  Bit Score: 139.82  E-value: 5.16e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938922020 185 TTLHCPTCVALGTCFNAPSLLCPNGTTRCYQGKLEITGGGIESSVEVKGCTATIGCRLMFGILAVGPMFVREVCPRQLLT 264
Cdd:cd23634     1 TTLHCPTCVALGSCFSAPSLPCPRGTTRCYQGRIQLTGGGISSDVEVKGCTTMIGCRLLGGIQTIGPIEVSEKCPRQSFL 80


                  ...
gi 1938922020 265 QPR 267
Cdd:cd23634    81 QPR 83
TFP_LU_ECD_LYPD4_rpt2_like cd23633
second extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4) ...
 185-259 1.77e-20

second extracellular domain (ECD) found in the Ly6/PLAUR domain-containing protein 4 (LYPD4)-like family; The LYPD4-like family includes LYPD4, testis-expressed protein 101 (TEX101), and CD177 antigen. LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. TEX101, also called cell surface receptor NYD-SP8, or scleroderma-associated autoantigen, or spermatogenesis-related gene protein (SGRG), is a germ cell-specific glycosylphosphatidylinositol (GPI)-anchored protein essential for sperm fertility and spermatogenesis. It plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct. It is associated with Ly6k during spermatogenesis in testes and is required for stable expression of lymphocyte antigen 6 family member K (Ly6k) on testicular germ cells. CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. LYPD4 and TEX101 contain two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). CD177 contains four ECD domains. The model corresponds to the second ECD domain of LYPD4 and TEX101, as well as second and fourth ECD domains of CD177.


Pssm-ID: 467797  Cd Length: 76  Bit Score: 83.51  E-value: 1.77e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1938922020 185 TTLHCPTCVAL-GTCF-NAPSLLCPNGTtRCYQGKLEITGGGIESSVEVKGCTATIGCRLMFGILAVGPMFVREVCP 259
Cdd:cd23633     1 GTLQCPVCLHFkGSCSsNSNLVLCPKNT-RCYTGDLEVRGGGLSATFSIKGCLAQSTKNLLNNQTSIGIFSVREILN 76
TFP_LU_ECD_CD177_rpt2 cd23636
second extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also ...
 186-258 2.95e-18

second extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1), and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the second ECD domain of CD177.


Pssm-ID: 467800  Cd Length: 77  Bit Score: 77.40  E-value: 2.95e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1938922020 186 TLHCPTCVALGTCFNAPSLL-CPNGTTRCYQGKLEITGGGIESSVEVKGCTATIGCRLMFGILAVGPMFVREVC 258
Cdd:cd23636     3 SLRCPVCLSTGSCPEAATLVpCPAGTTHCYSGVLRLRGGGISTNLKVQGCMPQPGCNLLNGTQTIGPISVSENC 76
TFP_LU_ECD_CD177_rpt3 cd23624
third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also ...
 75-170 1.82e-17

third extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the third ECD.


Pssm-ID: 467144  Cd Length: 102  Bit Score: 76.19  E-value: 1.82e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938922020  75 LYCQKSLSMTVEADPANM-FNWTTEEVETCDKGALCQETVLMIKAGTETAILAMKGC-IPDGEEAITIVQHSPHPGLIAI 152
Cdd:cd23624     2 LTCHQGVMVKFGSNLSKEpVEWTTSGTQICDAGEVCQETLLLIDVGPKSLLLGSKGCsKPGAQDSQKVSIHSGPPGILVA 81

                          90
                  ....*....|....*...
gi 1938922020 153 SYSNYCEDSFCNDKDSLS 170
Cdd:cd23624    82 SYVHFCSSDLCNRANSSS 99
TFP_LU_ECD_CD177_rpt4 cd23637
fourth extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also ...
 187-236 2.78e-13

fourth extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177, also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1), is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and show snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). The model corresponds to the fourth ECD domain of CD177.


Pssm-ID: 467801 [Multi-domain]  Cd Length: 77  Bit Score: 63.87  E-value: 2.78e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1938922020 187 LHCPTCVAL-GTCFNAPSLLCPNGTTRCYQGKLEITGGGIESSVEVKGCTA 236
Cdd:cd23637     4 LQCPVCVNFfGSCSDPSTVTCPKGTTHCYKGYIHLIGGGLSSTVNIQGCMA 54
TFP_LU_ECD_CD177_rpt1 cd23623
first extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also ...
 75-173 1.90e-12

first extracellular domain (ECD) found in CD177 antigen and similar proteins; CD177 (also called human neutrophil alloantigen 2a (HNA-2a), or NB1 glycoprotein (NB1 GP), or polycythemia rubra vera protein 1 (PRV-1)) is a cell surface protein normally expressed on neutrophil. It modulates the function and homeostasis of tumor-infiltrating regulatory T cells. The expression of CD177 is an important biomarker of myeloproliferative diseases. HNA-2a is expressed on subpopulations of neutrophils. Gene CD177 has two alleles: NB1 and PRV-1, which encode a glycosylphoshatidylinositol (GPI)-anchored protein with three N-glycosylation sites that belongs to the uPAR/CD59/Ly6 snake toxin superfamily. NB1 glycoprotein binds to the endothelial cell adhesion molecule, platelet endothelial cell adhesion molecule-1 (PECAM-1) and participates in neutrophil transmigration. PRV-1 is a novel hematopoietic cell surface receptor which is overexpressed in polycythemia rubra vera. Members in this family contain four extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467143  Cd Length: 100  Bit Score: 62.33  E-value: 1.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938922020  75 LYCQKSLSMTVEaDPANMFNWTTEEVETCDKGALCQETVLMIKAGTETAILAMKGCI--PDGEEAITivQHSPHPGLIAI 152
Cdd:cd23623     2 LTCQKGTLETVR-NVSELPLWWTAGQKTCEAGEGCQDTLMLIENGPQVNLVLIKGCTqaEDQEPRVT--QHRAGPGLSIV 78

                          90       100
                  ....*....|....*....|..
gi 1938922020 153 SYSNYC-EDSFCNDKDSLSQFW 173
Cdd:cd23623    79 SYTRVCrHQDLCNDLSSTLPLW 100
TFP_LU_ECD_LYPD4_rpt1 cd23621
first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 4 (LYPD4) and ...
 75-172 6.60e-05

first extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 4 (LYPD4) and similar proteins; LYPD4 is an acrosome protein expressed specifically in mammalian testes and sperm. It plays an essential role in mammalian fertilization. LYPD4 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467141  Cd Length: 103  Bit Score: 41.38  E-value: 6.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938922020  75 LYCQKSLSMTVEADPANMFNWTTEEVETCDKGALCQETVLMIKAGTETAILAMKGCIPDGEEAITIVQHSPHPGLIAISY 154
Cdd:cd23621     2 LLCYEATASRFRAVALHNWKWLLMRSMVCKLNEGCEETLVFIETGTARGVVGFKGCSPASSYPPQISYLVSPPGVSIASY 81

                          90
                  ....*....|....*...
gi 1938922020 155 SNYCEDSFCNDKDSLSQF 172
Cdd:cd23621    82 SRVCRSYLCNNLTNMEPF 99
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 189-258 1.20e-04

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 39.83  E-value: 1.20e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938922020 189 CPTCVALGTCFNAPSLLCPNGTTRCYQGKLEITGGGIESSVEVKGCTATIGCRLMFGILAVGPMFVREVC 258
Cdd:pfam00021   1 CYSCLGVSNEDCLSEVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCARSSCPRLLSDFINGGIISVSESC 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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