RING finger protein 17 isoform X1 [Callorhinchus milii]
List of domain hits
Name | Accession | Description | Interval | E-value | |||
Tudor_TDRD4_rpt5 | cd20418 | fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
1555-1659 | 2.06e-65 | |||
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. : Pssm-ID: 410489 Cd Length: 105 Bit Score: 216.51 E-value: 2.06e-65
|
|||||||
Tudor_TDRD4_rpt2 | cd20415 | second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
799-893 | 5.90e-48 | |||
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. : Pssm-ID: 410486 Cd Length: 96 Bit Score: 166.07 E-value: 5.90e-48
|
|||||||
Tudor_TDRD4_rpt3 | cd20416 | third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
1048-1128 | 4.79e-40 | |||
third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. : Pssm-ID: 410487 Cd Length: 82 Bit Score: 143.01 E-value: 4.79e-40
|
|||||||
Tudor_TDRD4_rpt4 | cd20417 | fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
1309-1376 | 1.45e-38 | |||
fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. : Pssm-ID: 410488 Cd Length: 68 Bit Score: 138.34 E-value: 1.45e-38
|
|||||||
Tudor_TDRD4_rpt1 | cd20414 | first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
562-637 | 1.03e-34 | |||
first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. : Pssm-ID: 410485 Cd Length: 77 Bit Score: 127.71 E-value: 1.03e-34
|
|||||||
TUDOR super family | cl26991 | Tudor domain; |
515-674 | 2.74e-06 | |||
Tudor domain; The actual alignment was detected with superfamily member pfam00567: Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 48.12 E-value: 2.74e-06
|
|||||||
RING_Ubox super family | cl17238 | RING finger (Really Interesting New Gene) domain and U-box domain superfamily; The RING finger ... |
13-70 | 3.92e-06 | |||
RING finger (Really Interesting New Gene) domain and U-box domain superfamily; The RING finger is a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc. It is defined by the "cross-brace" motif that chelates zinc atoms by eight amino acid residues, typically Cys or His, arranged in a characteristic spacing. Canonical RING motifs have been categorized into two major subclasses, RING-HC (C3HC4-type) and RING-H2 (C3H2C3-type), according to their Cys/His content. There are also many variants of RING fingers: some have different Cys/His patterns while some lack a single Cys or His residue at typical Zn ligand positions (the fourth or eighth zinc ligand is prevalently exchanged for an Asp, which can indeed chelate Zn in a RING finger as well). C4C4-, C3HC3D-, C2H2C4-, and C3HC5-type RING fingers are closely related to RING-HC fingers. In contrast, C4HC3- (RING-CH alias RINGv), C3H3C2-, C3H2C2D-, C3DHC3-, and C4HC2H-type RING fingers are more closely related to RING-H2 fingers. However, not all RING finger-containing proteins display regular RING finger features, and the RING finger family has turned out to be multifarious. The degenerate RING fingers of the Siz/PIAS RING (SP-RING) family proteins and sporulation protein RMD5, are characterized by lacking the second, fifth, and sixth Zn2+ ion-coordinating residues. They bind only one Zn2+ ion. On the other hand, the RING fingers of the human APC11 and RBX1 proteins can bind a third Zn atom since they harbor four additional Zn ligands. U-box is a modified form of the RING finger domain that lacks metal chelating Cys and His residues. It resembles the cross-brace RING structure consisting of three beta-sheets and a single alpha-helix, which would be stabilized by salt bridges instead of chelated metal ions. U-box proteins are widely distributed among eukaryotic organisms and show a higher prevalence in plants than in other organisms. RING finger/U-box-containing proteins are a group of diverse proteins with a variety of cellular functions, including oncogenesis, development, viral replication, signal transduction, the cell cycle and apoptosis. Many of them are ubiquitin-protein ligases (E3s) that serve as scaffolds for binding to ubiquitin-conjugating enzymes (E2s, also referred to as ubiquitin carrier proteins or UBCs) in close proximity to substrate proteins, which enable efficient transfer of ubiquitin from E2 to the substrates. The actual alignment was detected with superfamily member cd16559: Pssm-ID: 473075 [Multi-domain] Cd Length: 56 Bit Score: 45.69 E-value: 3.92e-06
|
|||||||
CC_brat-like super family | cl29238 | coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins; This family ... |
222-295 | 4.56e-03 | |||
coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins; This family contains the coiled-coil (CC) region of Drosophila brain tumor (Brat), a translational repressor that belongs to the tripartite motif (TRIM) protein superfamily. TRIM proteins play important roles in various cellular processes and are involved in many diseases which consists of two B-box domains and a coiled-coil (CC) domain at the N-terminal region, and an NHL domain at the C-terminus. Brat localizes at the basal cortex during asymmetric division of Drosophila neuroblasts by directly interacting with the scaffolding protein Miranda (Mira), which it does through the CC-NHL domain tandem, indicating that the function of the Brat CC domain is to assemble Brat-NHL in dimeric form which is necessary for Mira binding. Brat CC forms an elongated antiparallel dimer similar to its other TRIM protein counterparts, but the overall length of Brat CC dimer is shorter than the TRIMs. The actual alignment was detected with superfamily member smart00502: Pssm-ID: 475168 Cd Length: 127 Bit Score: 38.79 E-value: 4.56e-03
|
|||||||
Name | Accession | Description | Interval | E-value | |||
Tudor_TDRD4_rpt5 | cd20418 | fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
1555-1659 | 2.06e-65 | |||
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410489 Cd Length: 105 Bit Score: 216.51 E-value: 2.06e-65
|
|||||||
Tudor_TDRD4_rpt2 | cd20415 | second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
799-893 | 5.90e-48 | |||
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410486 Cd Length: 96 Bit Score: 166.07 E-value: 5.90e-48
|
|||||||
Tudor_TDRD4_rpt3 | cd20416 | third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
1048-1128 | 4.79e-40 | |||
third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410487 Cd Length: 82 Bit Score: 143.01 E-value: 4.79e-40
|
|||||||
Tudor_TDRD4_rpt4 | cd20417 | fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
1309-1376 | 1.45e-38 | |||
fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410488 Cd Length: 68 Bit Score: 138.34 E-value: 1.45e-38
|
|||||||
Tudor_TDRD4_rpt1 | cd20414 | first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
562-637 | 1.03e-34 | |||
first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410485 Cd Length: 77 Bit Score: 127.71 E-value: 1.03e-34
|
|||||||
TUDOR | pfam00567 | Tudor domain; |
774-890 | 3.37e-27 | |||
Tudor domain; Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 107.83 E-value: 3.37e-27
|
|||||||
TUDOR | pfam00567 | Tudor domain; |
1019-1133 | 1.42e-17 | |||
Tudor domain; Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 80.09 E-value: 1.42e-17
|
|||||||
TUDOR | pfam00567 | Tudor domain; |
1261-1375 | 5.94e-12 | |||
Tudor domain; Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 64.30 E-value: 5.94e-12
|
|||||||
TUDOR | pfam00567 | Tudor domain; |
1494-1626 | 8.58e-11 | |||
Tudor domain; Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 60.83 E-value: 8.58e-11
|
|||||||
TUDOR | smart00333 | Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ... |
822-876 | 1.20e-09 | |||
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished). Pssm-ID: 197660 Cd Length: 57 Bit Score: 55.36 E-value: 1.20e-09
|
|||||||
TUDOR | smart00333 | Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ... |
1562-1611 | 1.39e-08 | |||
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished). Pssm-ID: 197660 Cd Length: 57 Bit Score: 52.66 E-value: 1.39e-08
|
|||||||
TUDOR | pfam00567 | Tudor domain; |
515-674 | 2.74e-06 | |||
Tudor domain; Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 48.12 E-value: 2.74e-06
|
|||||||
RING-HC_RNF208 | cd16559 | RING finger, HC subclass, found in RING finger protein 208 (RNF208) and similar proteins; ... |
13-70 | 3.92e-06 | |||
RING finger, HC subclass, found in RING finger protein 208 (RNF208) and similar proteins; RNF208 is an E3 ubiquitin-protein ligase whose activity can be modulated by S-nitrosylation. It contains a C3HC4-type RING-HC finger. Pssm-ID: 438221 [Multi-domain] Cd Length: 56 Bit Score: 45.69 E-value: 3.92e-06
|
|||||||
RING | smart00184 | Ring finger; E3 ubiquitin-protein ligase activity is intrinsic to the RING domain of c-Cbl and ... |
13-64 | 5.55e-04 | |||
Ring finger; E3 ubiquitin-protein ligase activity is intrinsic to the RING domain of c-Cbl and is likely to be a general function of this domain; Various RING fingers exhibit binding activity towards E2 ubiquitin-conjugating enzymes (Ubc' s) Pssm-ID: 214546 [Multi-domain] Cd Length: 40 Bit Score: 39.03 E-value: 5.55e-04
|
|||||||
TUDOR | smart00333 | Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ... |
1307-1358 | 1.03e-03 | |||
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished). Pssm-ID: 197660 Cd Length: 57 Bit Score: 38.79 E-value: 1.03e-03
|
|||||||
TUDOR | smart00333 | Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ... |
1075-1120 | 1.03e-03 | |||
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished). Pssm-ID: 197660 Cd Length: 57 Bit Score: 38.79 E-value: 1.03e-03
|
|||||||
BBC | smart00502 | B-Box C-terminal domain; Coiled coil region C-terminal to (some) B-Box domains |
222-295 | 4.56e-03 | |||
B-Box C-terminal domain; Coiled coil region C-terminal to (some) B-Box domains Pssm-ID: 128778 Cd Length: 127 Bit Score: 38.79 E-value: 4.56e-03
|
|||||||
zf-RING_UBOX | pfam13445 | RING-type zinc-finger; This zinc-finger is a typical RING-type of plant ubiquitin ligases. |
13-62 | 5.30e-03 | |||
RING-type zinc-finger; This zinc-finger is a typical RING-type of plant ubiquitin ligases. Pssm-ID: 463881 [Multi-domain] Cd Length: 38 Bit Score: 36.22 E-value: 5.30e-03
|
|||||||
Name | Accession | Description | Interval | E-value | ||||
Tudor_TDRD4_rpt5 | cd20418 | fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
1555-1659 | 2.06e-65 | ||||
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410489 Cd Length: 105 Bit Score: 216.51 E-value: 2.06e-65
|
||||||||
Tudor_TDRD4_rpt2 | cd20415 | second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
799-893 | 5.90e-48 | ||||
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410486 Cd Length: 96 Bit Score: 166.07 E-value: 5.90e-48
|
||||||||
Tudor_TDRD4_rpt3 | cd20416 | third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
1048-1128 | 4.79e-40 | ||||
third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410487 Cd Length: 82 Bit Score: 143.01 E-value: 4.79e-40
|
||||||||
Tudor_TDRD4_rpt4 | cd20417 | fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
1309-1376 | 1.45e-38 | ||||
fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410488 Cd Length: 68 Bit Score: 138.34 E-value: 1.45e-38
|
||||||||
Tudor_TDRD4_rpt1 | cd20414 | first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
562-637 | 1.03e-34 | ||||
first Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410485 Cd Length: 77 Bit Score: 127.71 E-value: 1.03e-34
|
||||||||
TUDOR | pfam00567 | Tudor domain; |
774-890 | 3.37e-27 | ||||
Tudor domain; Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 107.83 E-value: 3.37e-27
|
||||||||
TUDOR | pfam00567 | Tudor domain; |
1019-1133 | 1.42e-17 | ||||
Tudor domain; Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 80.09 E-value: 1.42e-17
|
||||||||
Tudor_AKAP1 | cd20407 | Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; ... |
822-893 | 2.79e-17 | ||||
Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410478 Cd Length: 76 Bit Score: 78.02 E-value: 2.79e-17
|
||||||||
Tudor_TDRD1_rpt1 | cd20408 | first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ... |
778-902 | 1.18e-16 | ||||
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410479 Cd Length: 130 Bit Score: 78.18 E-value: 1.18e-16
|
||||||||
Tudor_TDRD2 | cd20412 | Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, ... |
802-886 | 1.90e-16 | ||||
Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410483 Cd Length: 95 Bit Score: 76.18 E-value: 1.90e-16
|
||||||||
Tudor_TDRD15_rpt4 | cd20439 | fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ... |
776-888 | 2.68e-16 | ||||
fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410510 Cd Length: 125 Bit Score: 76.76 E-value: 2.68e-16
|
||||||||
Tudor_TDRD15_rpt2 | cd20437 | second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ... |
777-890 | 1.38e-15 | ||||
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410508 Cd Length: 120 Bit Score: 74.76 E-value: 1.38e-15
|
||||||||
Tudor_TDRD6_rpt7 | cd20426 | seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
776-911 | 1.08e-14 | ||||
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410497 Cd Length: 140 Bit Score: 72.92 E-value: 1.08e-14
|
||||||||
Tudor_TDRD6_rpt3 | cd20422 | third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
778-893 | 1.46e-14 | ||||
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410493 Cd Length: 135 Bit Score: 72.16 E-value: 1.46e-14
|
||||||||
Tudor_TDRD6_rpt6 | cd20425 | sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
777-888 | 1.74e-14 | ||||
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410496 Cd Length: 115 Bit Score: 71.33 E-value: 1.74e-14
|
||||||||
Tudor_TDRD7_rpt1 | cd20427 | first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ... |
805-893 | 6.67e-14 | ||||
first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410498 Cd Length: 98 Bit Score: 68.99 E-value: 6.67e-14
|
||||||||
Tudor_TDRD1_rpt1 | cd20408 | first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ... |
1030-1141 | 3.12e-13 | ||||
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410479 Cd Length: 130 Bit Score: 68.17 E-value: 3.12e-13
|
||||||||
Tudor_TDRD6_rpt5 | cd20424 | fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
777-888 | 2.22e-12 | ||||
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410495 Cd Length: 126 Bit Score: 65.60 E-value: 2.22e-12
|
||||||||
Tudor_TDRD15_rpt5 | cd20440 | fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ... |
777-888 | 3.98e-12 | ||||
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410511 Cd Length: 127 Bit Score: 64.78 E-value: 3.98e-12
|
||||||||
TUDOR | pfam00567 | Tudor domain; |
1261-1375 | 5.94e-12 | ||||
Tudor domain; Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 64.30 E-value: 5.94e-12
|
||||||||
Tudor_TDRD1_rpt3 | cd20410 | third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ... |
822-877 | 1.47e-11 | ||||
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 61.20 E-value: 1.47e-11
|
||||||||
Tudor_TDRD1_rpt4 | cd20411 | fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ... |
778-889 | 2.47e-11 | ||||
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410482 Cd Length: 116 Bit Score: 62.46 E-value: 2.47e-11
|
||||||||
Tudor_dTUD-like | cd20379 | Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ... |
824-872 | 2.60e-11 | ||||
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410450 Cd Length: 50 Bit Score: 59.84 E-value: 2.60e-11
|
||||||||
Tudor_TDRD5 | cd20419 | Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is ... |
780-888 | 4.35e-11 | ||||
Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410490 Cd Length: 118 Bit Score: 61.70 E-value: 4.35e-11
|
||||||||
Tudor_TDRD15_rpt6 | cd20441 | sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ... |
785-891 | 7.94e-11 | ||||
sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410512 Cd Length: 108 Bit Score: 60.52 E-value: 7.94e-11
|
||||||||
TUDOR | pfam00567 | Tudor domain; |
1494-1626 | 8.58e-11 | ||||
Tudor domain; Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 60.83 E-value: 8.58e-11
|
||||||||
Tudor_TDRD6_rpt2 | cd20421 | second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
778-888 | 6.31e-10 | ||||
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410492 Cd Length: 130 Bit Score: 58.59 E-value: 6.31e-10
|
||||||||
TUDOR | smart00333 | Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ... |
822-876 | 1.20e-09 | ||||
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished). Pssm-ID: 197660 Cd Length: 57 Bit Score: 55.36 E-value: 1.20e-09
|
||||||||
Tudor_TDRD11 | cd20433 | Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ... |
1536-1615 | 1.60e-09 | ||||
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 56.15 E-value: 1.60e-09
|
||||||||
Tudor_TDRD4_rpt5 | cd20418 | fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
828-908 | 3.04e-09 | ||||
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410489 Cd Length: 105 Bit Score: 55.88 E-value: 3.04e-09
|
||||||||
Tudor_dTUD-like | cd20379 | Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ... |
1069-1116 | 6.93e-09 | ||||
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410450 Cd Length: 50 Bit Score: 53.29 E-value: 6.93e-09
|
||||||||
TUDOR | smart00333 | Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ... |
1562-1611 | 1.39e-08 | ||||
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished). Pssm-ID: 197660 Cd Length: 57 Bit Score: 52.66 E-value: 1.39e-08
|
||||||||
Tudor_TDRD15_rpt3 | cd20438 | third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ... |
780-906 | 1.44e-08 | ||||
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410509 Cd Length: 141 Bit Score: 55.17 E-value: 1.44e-08
|
||||||||
Tudor_TDRD12_rpt2 | cd20435 | second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ... |
785-900 | 1.98e-08 | ||||
second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410506 Cd Length: 134 Bit Score: 54.56 E-value: 1.98e-08
|
||||||||
Tudor_TDRD7_rpt2 | cd20428 | second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ... |
822-895 | 2.22e-08 | ||||
second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410499 Cd Length: 140 Bit Score: 54.76 E-value: 2.22e-08
|
||||||||
Tudor_dTUD-like | cd20379 | Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ... |
1562-1610 | 2.68e-08 | ||||
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410450 Cd Length: 50 Bit Score: 51.36 E-value: 2.68e-08
|
||||||||
Tudor_TDRD1_rpt1 | cd20408 | first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ... |
1285-1388 | 2.71e-08 | ||||
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410479 Cd Length: 130 Bit Score: 53.91 E-value: 2.71e-08
|
||||||||
Tudor_TDRD4_rpt2 | cd20415 | second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
1550-1631 | 2.88e-08 | ||||
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410486 Cd Length: 96 Bit Score: 52.82 E-value: 2.88e-08
|
||||||||
Tudor_TDRD15_rpt2 | cd20437 | second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ... |
1021-1133 | 5.55e-08 | ||||
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410508 Cd Length: 120 Bit Score: 52.81 E-value: 5.55e-08
|
||||||||
Tudor_TDRD11 | cd20433 | Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ... |
825-876 | 5.70e-08 | ||||
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 51.53 E-value: 5.70e-08
|
||||||||
Tudor_TDRD1_rpt1 | cd20408 | first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ... |
515-690 | 9.90e-08 | ||||
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410479 Cd Length: 130 Bit Score: 52.37 E-value: 9.90e-08
|
||||||||
Tudor_TDRD6_rpt4 | cd20423 | fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
827-895 | 1.27e-07 | ||||
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410494 Cd Length: 80 Bit Score: 50.56 E-value: 1.27e-07
|
||||||||
Tudor_TDRD15_rpt2 | cd20437 | second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ... |
1264-1355 | 1.49e-07 | ||||
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410508 Cd Length: 120 Bit Score: 51.65 E-value: 1.49e-07
|
||||||||
Tudor_TDRD6_rpt4 | cd20423 | fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
1557-1634 | 1.56e-07 | ||||
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410494 Cd Length: 80 Bit Score: 50.17 E-value: 1.56e-07
|
||||||||
Tudor_TDRD1_rpt2 | cd20409 | second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ... |
821-877 | 1.63e-07 | ||||
second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410480 Cd Length: 82 Bit Score: 50.53 E-value: 1.63e-07
|
||||||||
Tudor_AtTudor1-like | cd20443 | Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor ... |
822-893 | 1.78e-07 | ||||
Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 51.31 E-value: 1.78e-07
|
||||||||
Tudor_TDRD15_rpt3 | cd20438 | third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ... |
1025-1154 | 2.22e-07 | ||||
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410509 Cd Length: 141 Bit Score: 51.71 E-value: 2.22e-07
|
||||||||
Tudor_TDRD15_rpt4 | cd20439 | fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ... |
1021-1135 | 3.43e-07 | ||||
fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410510 Cd Length: 125 Bit Score: 50.95 E-value: 3.43e-07
|
||||||||
Tudor_dTUD-like | cd20379 | Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ... |
1311-1358 | 4.55e-07 | ||||
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410450 Cd Length: 50 Bit Score: 47.90 E-value: 4.55e-07
|
||||||||
Tudor_TDRD15_rpt7 | cd20442 | seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ... |
1022-1143 | 4.77e-07 | ||||
seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410513 Cd Length: 160 Bit Score: 51.19 E-value: 4.77e-07
|
||||||||
Tudor_TDRD9 | cd20431 | Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is ... |
781-880 | 7.57e-07 | ||||
Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410502 Cd Length: 101 Bit Score: 48.92 E-value: 7.57e-07
|
||||||||
Tudor_TDRD8 | cd20430 | Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, ... |
822-861 | 9.45e-07 | ||||
Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 48.06 E-value: 9.45e-07
|
||||||||
Tudor_TDRD12_rpt2 | cd20435 | second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ... |
1564-1632 | 1.52e-06 | ||||
second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410506 Cd Length: 134 Bit Score: 49.17 E-value: 1.52e-06
|
||||||||
Tudor_TDRD6_rpt6 | cd20425 | sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
1021-1132 | 1.91e-06 | ||||
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410496 Cd Length: 115 Bit Score: 48.22 E-value: 1.91e-06
|
||||||||
TUDOR | pfam00567 | Tudor domain; |
515-674 | 2.74e-06 | ||||
Tudor domain; Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 48.12 E-value: 2.74e-06
|
||||||||
Tudor_TDRD1_rpt2 | cd20409 | second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ... |
1538-1611 | 3.31e-06 | ||||
second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410480 Cd Length: 82 Bit Score: 46.68 E-value: 3.31e-06
|
||||||||
RING-HC_RNF208 | cd16559 | RING finger, HC subclass, found in RING finger protein 208 (RNF208) and similar proteins; ... |
13-70 | 3.92e-06 | ||||
RING finger, HC subclass, found in RING finger protein 208 (RNF208) and similar proteins; RNF208 is an E3 ubiquitin-protein ligase whose activity can be modulated by S-nitrosylation. It contains a C3HC4-type RING-HC finger. Pssm-ID: 438221 [Multi-domain] Cd Length: 56 Bit Score: 45.69 E-value: 3.92e-06
|
||||||||
Tudor_TDRD6_rpt2 | cd20421 | second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
1484-1618 | 6.47e-06 | ||||
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410492 Cd Length: 130 Bit Score: 47.42 E-value: 6.47e-06
|
||||||||
RING-HC_RNF224 | cd16565 | RING finger, HC subclass, found in RING finger protein RNF224 and similar proteins; RNF224 is ... |
28-70 | 1.04e-05 | ||||
RING finger, HC subclass, found in RING finger protein RNF224 and similar proteins; RNF224 is uncharacterized C3HC4-type RING-HC finger-containing proteins. It may function as an E3 ubiquitin-protein ligase. Pssm-ID: 438227 [Multi-domain] Cd Length: 59 Bit Score: 44.43 E-value: 1.04e-05
|
||||||||
Tudor_TDRD1_rpt1 | cd20408 | first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ... |
1564-1632 | 1.54e-05 | ||||
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410479 Cd Length: 130 Bit Score: 46.21 E-value: 1.54e-05
|
||||||||
Tudor_TDRD9 | cd20431 | Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is ... |
1552-1618 | 2.04e-05 | ||||
Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410502 Cd Length: 101 Bit Score: 45.07 E-value: 2.04e-05
|
||||||||
Tudor_TDRD6_rpt3 | cd20422 | third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
1022-1153 | 2.76e-05 | ||||
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410493 Cd Length: 135 Bit Score: 45.58 E-value: 2.76e-05
|
||||||||
Tudor_TDRD4_rpt2 | cd20415 | second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
1304-1369 | 3.35e-05 | ||||
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410486 Cd Length: 96 Bit Score: 44.35 E-value: 3.35e-05
|
||||||||
Tudor_TDRD5 | cd20419 | Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is ... |
1500-1626 | 3.80e-05 | ||||
Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410490 Cd Length: 118 Bit Score: 44.75 E-value: 3.80e-05
|
||||||||
Tudor_TDRD6_rpt7 | cd20426 | seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
1021-1158 | 4.09e-05 | ||||
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410497 Cd Length: 140 Bit Score: 45.18 E-value: 4.09e-05
|
||||||||
Tudor_TDRD6_rpt3 | cd20422 | third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
1303-1388 | 4.50e-05 | ||||
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410493 Cd Length: 135 Bit Score: 44.81 E-value: 4.50e-05
|
||||||||
Tudor_TDRD1_rpt4 | cd20411 | fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ... |
1312-1373 | 4.96e-05 | ||||
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410482 Cd Length: 116 Bit Score: 44.36 E-value: 4.96e-05
|
||||||||
Tudor_TDRD11 | cd20433 | Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ... |
1048-1118 | 5.14e-05 | ||||
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 43.44 E-value: 5.14e-05
|
||||||||
Tudor_TDRD6_rpt7 | cd20426 | seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
1563-1629 | 5.73e-05 | ||||
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410497 Cd Length: 140 Bit Score: 44.80 E-value: 5.73e-05
|
||||||||
RING-HC_TRIM32_C-VII | cd16587 | RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar ... |
13-64 | 5.88e-05 | ||||
RING finger, HC subclass, found in tripartite motif-containing protein 32 (TRIM32) and similar proteins; TRIM32, also known as 72 kDa Tat-interacting protein, zinc finger protein HT2A, or BBS11, is an E3 ubiquitin-protein ligase that promotes degradation of several targets, including actin, PIASgamma, Abl interactor 2, dysbindin, X-linked inhibitor of apoptosis (XIAP), p73 transcription factor, thin filaments and Z-bands during fasting. It plays important roles in neuronal differentiation of neural progenitor cells, as well as in controlling cell fate in skeletal muscle progenitor cells. It reduces PI3K-Akt-FoxO signaling in muscle atrophy by promoting plakoglobin-PI3K dissociation. It also functions as a pluripotency-reprogramming roadblock that facilitates cellular transition towards differentiation by modulating the levels of Oct4 and cMyc. Moreover, TRIM32 is an intrinsic influenza A virus (IAV) restriction factor which senses and targets the polymerase basic protein 1 (PB1) for ubiquitination and protein degradation. It also plays a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo, binds specifically to the activation domain of HIV-1 Tat, and can also interact with the HIV-2 and EIAV Tat proteins in vivo. Furthermore, TRIM32 regulates myoblast proliferation by controlling turnover of NDRG2 (N-myc downstream-regulated gene). It negatively regulates tumor suppressor p53 to promote tumorigenesis. It also facilitates degradation of MYCN on spindle poles and induces asymmetric cell division in human neuroblastoma cells. In addition, TRIM32 plays important roles in regulation of hyperactivities and positively regulates the development of anxiety and depression disorders induced by chronic stress. It also plays a role in regeneration by affecting satellite cell cycle progression via modulation of the SUMO ligase PIASy (PIAS4). Defects in TRIM32 leads to limb-girdle muscular dystrophy type 2H (LGMD2H), sarcotubular myopathies (STM) and Bardet-Biedl syndrome. TRIM32 belongs to the C-VII subclass of the TRIM (tripartite motif)-NHL family that is defined by their N-terminal RBCC (RING, Bbox, and coiled coil) domains, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil domain, as well as a NHL (named after proteins NCL-1, HT2A and Lin-41 that contain repeats folded into a six-bladed beta propeller) repeat domain positioned C-terminal to the RBCC domain. The NHL domain mediates the interaction with Argonaute proteins and consequently allows TRIM32 to modulate the activity of certain miRNAs. Pssm-ID: 438249 [Multi-domain] Cd Length: 51 Bit Score: 42.00 E-value: 5.88e-05
|
||||||||
Tudor_TDRD15_rpt5 | cd20440 | fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ... |
1022-1132 | 6.43e-05 | ||||
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410511 Cd Length: 127 Bit Score: 44.37 E-value: 6.43e-05
|
||||||||
Tudor_TDRD6_rpt2 | cd20421 | second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
1023-1116 | 6.47e-05 | ||||
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410492 Cd Length: 130 Bit Score: 44.34 E-value: 6.47e-05
|
||||||||
Tudor_TDRD11 | cd20433 | Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ... |
1302-1358 | 8.47e-05 | ||||
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 42.67 E-value: 8.47e-05
|
||||||||
RING-HC_RNF39 | cd16592 | RING finger, HC subclass, found in RING finger protein 39 (RNF39) and similar proteins; RNF39, ... |
9-69 | 9.70e-05 | ||||
RING finger, HC subclass, found in RING finger protein 39 (RNF39) and similar proteins; RNF39, also called protein HZFw, may play a role in prolonged long term-potentiation (LTP) maintenance. It is involved in the etiology of Behcet's disease (BD). It may also be involved in HIV-1 replication. RNF39 acts as an E3 ubiquitin ligase that inhibits retinoic acid-inducible gene-I (RIG-I)-like receptor (RLR) pathways by mediating K48-linked ubiquitination and proteasomal degradation of DDX3X (DEAD-box RNA helicase 3, X-linked). RNF39 contains a typical C3HC4-type RING-HC finger. Pssm-ID: 438254 [Multi-domain] Cd Length: 58 Bit Score: 41.67 E-value: 9.70e-05
|
||||||||
Tudor_TDRD1_rpt3 | cd20410 | third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ... |
1310-1351 | 1.00e-04 | ||||
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 41.56 E-value: 1.00e-04
|
||||||||
Tudor_TDRD6_rpt4 | cd20423 | fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
1077-1140 | 1.45e-04 | ||||
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410494 Cd Length: 80 Bit Score: 42.08 E-value: 1.45e-04
|
||||||||
Tudor_AtTudor1-like | cd20443 | Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor ... |
1565-1632 | 1.49e-04 | ||||
Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 42.84 E-value: 1.49e-04
|
||||||||
Tudor_TDRD1_rpt4 | cd20411 | fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ... |
1564-1628 | 1.63e-04 | ||||
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410482 Cd Length: 116 Bit Score: 42.82 E-value: 1.63e-04
|
||||||||
Tudor_AtTudor1-like | cd20443 | Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor ... |
1081-1137 | 1.88e-04 | ||||
Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 42.84 E-value: 1.88e-04
|
||||||||
Tudor_TDRD15_rpt3 | cd20438 | third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ... |
1315-1393 | 2.69e-04 | ||||
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410509 Cd Length: 141 Bit Score: 42.85 E-value: 2.69e-04
|
||||||||
RING-HC_RNF183-like | cd16556 | RING finger, HC subclass, found in RING finger protein RNF183, RNF223, RNF225 and similar ... |
13-64 | 4.04e-04 | ||||
RING finger, HC subclass, found in RING finger protein RNF183, RNF223, RNF225 and similar proteins; RNF183 is an E3 ubiquitin-protein ligase that is upregulated during intestinal inflammation and is negatively regulated by miR-7. It promotes intestinal inflammation by increasing the ubiquitination and degradation of inhibitor of kappa B, thereby resulting in secondary activation of the Nuclear factor-kappaB (NF-kB) pathway. The interaction between RNF183-mediated ubiquitination and miRNA may be an important novel epigenetic mechanism in the pathogenesis of inflammatory bowel disease (IBD). The biological function of RNF223 and RNF225 remains unclear. Members of this family contain an N-terminal C3HC4-type RING-HC finger. Pssm-ID: 438218 [Multi-domain] Cd Length: 57 Bit Score: 40.04 E-value: 4.04e-04
|
||||||||
Tudor_TDRD10 | cd20432 | Tudor domain found in Tudor domain-containing protein 10 (TDRD10) and similar proteins; TDRD10 ... |
825-880 | 4.76e-04 | ||||
Tudor domain found in Tudor domain-containing protein 10 (TDRD10) and similar proteins; TDRD10 is widely expressed and localized both to the nucleus and cytoplasm, and may play general roles like regulation of RNA metabolism. It contains a Tudor domain and an RNA recognition motif (RRM). The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410503 Cd Length: 139 Bit Score: 42.03 E-value: 4.76e-04
|
||||||||
RING | smart00184 | Ring finger; E3 ubiquitin-protein ligase activity is intrinsic to the RING domain of c-Cbl and ... |
13-64 | 5.55e-04 | ||||
Ring finger; E3 ubiquitin-protein ligase activity is intrinsic to the RING domain of c-Cbl and is likely to be a general function of this domain; Various RING fingers exhibit binding activity towards E2 ubiquitin-conjugating enzymes (Ubc' s) Pssm-ID: 214546 [Multi-domain] Cd Length: 40 Bit Score: 39.03 E-value: 5.55e-04
|
||||||||
Tudor_TDRD1_rpt3 | cd20410 | third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ... |
1563-1615 | 5.82e-04 | ||||
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 39.63 E-value: 5.82e-04
|
||||||||
Tudor_TDRD2 | cd20412 | Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, ... |
1569-1622 | 6.28e-04 | ||||
Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410483 Cd Length: 95 Bit Score: 40.74 E-value: 6.28e-04
|
||||||||
RING-HC | cd16449 | HC subclass of RING (RING-HC) finger and its variants; The RING finger is a specialized type ... |
13-64 | 6.44e-04 | ||||
HC subclass of RING (RING-HC) finger and its variants; The RING finger is a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc. It is defined by the "cross-brace" motif that chelates zinc atoms by eight amino acid residues, typically Cys or His, arranged in a characteristic spacing. Canonical RING motifs have been categorized into two major subclasses, RING-HC (C3HC4-type) and RING-H2 (C3H2C3-type), according to their Cys/His content. There are also many variants of RING fingers. Some have a different Cys/His pattern. Some lack a single Cys or His residue at typical Zn ligand positions, especially, the fourth or eighth zinc ligand is prevalently exchanged for an Asp, which can chelate Zn in a RING finger as well. This family corresponds to the HC subclass of RING (RING-HC) fingers that are characterized by containing C3HC4-type canonical RING-HC fingers or noncanonical RING-HC finger variants, including C4C4-, C3HC3D-, C2H2C4-, and C3HC5-type modified RING-HC fingers. The canonical RING-HC finger has been defined as C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C. It binds two Zn ions in a unique "cross-brace" arrangement, which distinguishes it from tandem zinc fingers and other similar motifs. RING-HC fingers can be found in a group of diverse proteins with a variety of cellular functions, including oncogenesis, development, viral replication, signal transduction, the cell cycle, and apoptosis. Many of them are ubiquitin-protein ligases (E3s) that serve as scaffolds for binding to ubiquitin-conjugating enzymes (E2s, also referred to as ubiquitin carrier proteins or UBCs) in close proximity to substrate proteins, which enables efficient transfer of ubiquitin from E2 to the substrates. Pssm-ID: 438113 [Multi-domain] Cd Length: 41 Bit Score: 39.01 E-value: 6.44e-04
|
||||||||
RING-HC_RNF222 | cd16564 | RING finger, HC subclass, found in RING finger protein 222 (RNF222) and similar proteins; ... |
13-64 | 6.84e-04 | ||||
RING finger, HC subclass, found in RING finger protein 222 (RNF222) and similar proteins; RNF222 is an uncharacterized C3HC4-type RING-HC finger-containing protein. It may function as an E3 ubiquitin-protein ligase. Pssm-ID: 438226 [Multi-domain] Cd Length: 50 Bit Score: 38.92 E-value: 6.84e-04
|
||||||||
Tudor_TDRD4_rpt3 | cd20416 | third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
828-884 | 7.50e-04 | ||||
third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410487 Cd Length: 82 Bit Score: 40.16 E-value: 7.50e-04
|
||||||||
Tudor_SMN_SPF30-like | cd21182 | Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing ... |
825-872 | 8.54e-04 | ||||
Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410549 Cd Length: 50 Bit Score: 38.77 E-value: 8.54e-04
|
||||||||
TUDOR | smart00333 | Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ... |
1307-1358 | 1.03e-03 | ||||
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished). Pssm-ID: 197660 Cd Length: 57 Bit Score: 38.79 E-value: 1.03e-03
|
||||||||
TUDOR | smart00333 | Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ... |
1075-1120 | 1.03e-03 | ||||
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished). Pssm-ID: 197660 Cd Length: 57 Bit Score: 38.79 E-value: 1.03e-03
|
||||||||
RING-HC_malin | cd16516 | RING finger, HC subclass, found in malin and similar proteins; Malin ("mal" for seizure in ... |
14-65 | 1.33e-03 | ||||
RING finger, HC subclass, found in malin and similar proteins; Malin ("mal" for seizure in French), also known as NHL repeat-containing protein 1 (NHLRC1), or EPM2B, is a nuclear E3 ubiquitin-protein ligase that ubiquitinates and promotes the degradation of laforin (EPM2A encoding protein phosphatase). Malin and laforin operate as a functional complex that play key roles in regulating cellular functions such as glycogen metabolism, unfolded cellular stress response, and proteolytic processes. They act as pro-survival factors that negatively regulate the Hipk2-p53 cell death pathway. They also negatively regulate cellular glucose uptake by preventing plasma membrane targeting of glucose transporters. Moreover, they degrade polyglucosan bodies in concert with glycogen debranching enzyme and brain isoform glycogen phosphorylase. Furthermore, they, together with Hsp70, form a new functional complex that suppress the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system. Defects in either malin or laforin may cause Lafora disease (LD), a fatal form of teenage-onset autosomal recessive progressive myoclonus epilepsy. In addition, malin may have function, independent of laforin, in lysosomal biogenesis and/or lysosomal glycogen disposal. Malin contains six NHL-repeat protein-protein interaction domains and a C3HC4-type RING-HC finger. Pssm-ID: 438179 [Multi-domain] Cd Length: 52 Bit Score: 38.26 E-value: 1.33e-03
|
||||||||
Tudor_TDRD6_rpt5 | cd20424 | fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
1264-1358 | 1.35e-03 | ||||
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410495 Cd Length: 126 Bit Score: 40.57 E-value: 1.35e-03
|
||||||||
Tudor_TDRD7_rpt1 | cd20427 | first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ... |
1299-1378 | 1.44e-03 | ||||
first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410498 Cd Length: 98 Bit Score: 39.72 E-value: 1.44e-03
|
||||||||
RING-HC_RNFT1-like | cd16532 | RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein ... |
11-50 | 1.66e-03 | ||||
RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein RNFT1, RNFT2, and similar proteins; Both RNFT1 and RNFT2 are multi-pass membrane proteins containing a C3HC4-type RING-HC finger. Their biological roles remain unclear. Pssm-ID: 438194 [Multi-domain] Cd Length: 41 Bit Score: 37.67 E-value: 1.66e-03
|
||||||||
Tudor_TDRD6_rpt2 | cd20421 | second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
1312-1375 | 1.70e-03 | ||||
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410492 Cd Length: 130 Bit Score: 40.10 E-value: 1.70e-03
|
||||||||
Tudor_TDRD6_rpt5 | cd20424 | fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
1548-1626 | 2.46e-03 | ||||
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410495 Cd Length: 126 Bit Score: 39.80 E-value: 2.46e-03
|
||||||||
Tudor_TDRD4_rpt2 | cd20415 | second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ... |
1048-1137 | 3.22e-03 | ||||
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410486 Cd Length: 96 Bit Score: 38.57 E-value: 3.22e-03
|
||||||||
RING-HC_RBR_RNF19 | cd16629 | RING finger, HC subclass, found in the family of RING finger proteins RNF19A, RNF19B and ... |
12-65 | 4.11e-03 | ||||
RING finger, HC subclass, found in the family of RING finger proteins RNF19A, RNF19B and similar proteins; The family includes RING finger protein RNF19A and RNF19B, both of which are transmembrane (TM) domain-containing RBR-type E3 ubiquitin-protein ligases. RNF19A, also known as double ring-finger protein (Dorfin) or p38, localizes to the ubiquitylated inclusions in Parkinson's disease (PD), dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis (ALS). It interacts with Psmc3, a protein component of the 19S regulatory cap of the 26S proteasome, and further participates in the ubiquitin-proteasome system in acrosome biogenesis, spermatid head shaping, and development of the head-tail coupling apparatus and tail. It modulates the ubiquitination and degradation of calcium-sensing receptor (CaR), which may contribute to a general mechanism for CaR quality control during biosynthesis. Moreover, RNF19A can also ubiquitylate mutant superoxide dismutase 1 (SOD1), the causative gene of familial ALS. It may associate with endoplasmic reticulum-associated degradation (ERAD) pathway, which is related to the pathogenesis of neurodegenerative disorders, such as PD or Alzheimer's disease. RNF19B, also known as IBR domain-containing protein 3 or natural killer lytic-associated molecule (NKLAM), plays a role in controlling tumor dissemination and metastasis. It is involved in the cytolytic function of natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). It interacts with ubiquitin conjugates UbcH7 and UbcH8, and ubiquitinates uridine kinase like-1 (URKL-1) protein, targeting it for degradation. Moreover, RNF19B is a novel component of macrophage phagosomes and plays a role in macrophage anti-bacterial activity. It functions as a novel modulator of macrophage inducible nitric oxide synthase (iNOS) expression. Both RNF19A and RNF19B contain an RBR domain followed by three TMs. The RBR domain was previously known as RING-BetweenRING-RING domain or TRIAD [two RING fingers and a DRIL (double RING finger linked)] domain. Based on current understanding of the structural biology of RBR ligases, the nomenclature of RBR has been corrected as RING-BRcat (benign-catalytic)-Rcat (required-for-catalysis) recently. The RBR (RING1-BRcat-Rcat) domain uses an auto-inhibitory mechanism to modulate ubiquitination activity, as well as a hybrid mechanism that combines aspects from both RING and HECT E3 ligase function to facilitate the ubiquitination reaction. This model corresponds to the RING domain, a C3HC4-type RING-HC finger required for RBR-mediated ubiquitination. Pssm-ID: 438291 [Multi-domain] Cd Length: 56 Bit Score: 37.04 E-value: 4.11e-03
|
||||||||
Tudor_TDRD15_rpt1 | cd20436 | first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ... |
1308-1394 | 4.38e-03 | ||||
first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410507 Cd Length: 147 Bit Score: 39.33 E-value: 4.38e-03
|
||||||||
RING-HC_KEG-like | cd23140 | RING finger, HC subclass, found in Arabidopsis thaliana protein KEEP ON GOING (KEG) and ... |
10-70 | 4.54e-03 | ||||
RING finger, HC subclass, found in Arabidopsis thaliana protein KEEP ON GOING (KEG) and similar proteins; KEG, also called RING-type E3 ubiquitin transferase KEG, is a RING E3 ubiquitin-protein ligase that mediates E2-dependent protein ubiquitination. It is essential for Arabidopsis growth and development. It acts as a negative regulator of abscisic acid signaling. It is required for ABSCISIC ACID-INSENSITIVE5 (ABI5) degradation, by mediating its ubiquitination. Together with EDR1, KEG may regulate endocytic trafficking and/or the formation of signaling complexes on trans-Golgi network (TGN)/ early endosome (EE) vesicles during stress responses. KEG is a multidomain protein that includes a C3HC4-type RING-HC finger, a kinase domain, ankyrin repeats, and 12 HERC2-like (for HECT and RCC1-like) repeats. Pssm-ID: 438502 [Multi-domain] Cd Length: 57 Bit Score: 36.85 E-value: 4.54e-03
|
||||||||
BBC | smart00502 | B-Box C-terminal domain; Coiled coil region C-terminal to (some) B-Box domains |
222-295 | 4.56e-03 | ||||
B-Box C-terminal domain; Coiled coil region C-terminal to (some) B-Box domains Pssm-ID: 128778 Cd Length: 127 Bit Score: 38.79 E-value: 4.56e-03
|
||||||||
Tudor_TDRD15_rpt6 | cd20441 | sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ... |
1030-1135 | 4.86e-03 | ||||
sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410512 Cd Length: 108 Bit Score: 38.57 E-value: 4.86e-03
|
||||||||
zf-RING_UBOX | pfam13445 | RING-type zinc-finger; This zinc-finger is a typical RING-type of plant ubiquitin ligases. |
13-62 | 5.30e-03 | ||||
RING-type zinc-finger; This zinc-finger is a typical RING-type of plant ubiquitin ligases. Pssm-ID: 463881 [Multi-domain] Cd Length: 38 Bit Score: 36.22 E-value: 5.30e-03
|
||||||||
RING-HC_RNF138 | cd16544 | RING finger, HC subclass, found in RING finger protein 138 (RNF138) and similar proteins; ... |
13-65 | 5.34e-03 | ||||
RING finger, HC subclass, found in RING finger protein 138 (RNF138) and similar proteins; RNF138, also known as Nemo-like kinase-associated RING finger protein (NARF) or NLK-associated RING finger protein, is an E3 ubiquitin-protein ligase that plays an important role in glioma cell proliferation, apoptosis, and cell cycle. It specifically cooperates with the E2 conjugating enzyme E2-25K (Hip-2/UbcH1), regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF), and further suppresses Wnt-beta-catenin signaling. RNF138, together with three closely related proteins: RNF114, RNF125 and RNF166, forms a novel family of ubiquitin ligases with a C3HC4-type RING-HC finger, a C2HC-, and two C2H2-type zinc fingers, as well as a ubiquitin interacting motif (UIM). Pssm-ID: 438206 [Multi-domain] Cd Length: 53 Bit Score: 36.61 E-value: 5.34e-03
|
||||||||
RING-HC_RNF186 | cd16557 | RING finger, HC subclass, found in RING finger protein 186 (RNF186) and similar proteins; ... |
13-65 | 5.57e-03 | ||||
RING finger, HC subclass, found in RING finger protein 186 (RNF186) and similar proteins; RNF186 is an E3 ubiquitin-protein ligase with an N-terminal C3HC4-type RING-HC finger and two putative C-terminal transmembrane domains which enable it to localize in a certain organelle. It regulates RING-dependent self-ubiquitination, as well as endoplasmic reticulum (ER) stress-mediated apoptosis through interaction with the Bcl-2 family protein BNip1. Pssm-ID: 438219 [Multi-domain] Cd Length: 52 Bit Score: 36.76 E-value: 5.57e-03
|
||||||||
RING-HC_PML_C-V | cd16579 | RING finger, HC subclass, found in promyelocytic leukemia protein (PML) and similar proteins; ... |
13-65 | 5.93e-03 | ||||
RING finger, HC subclass, found in promyelocytic leukemia protein (PML) and similar proteins; Protein PML, also known as RING finger protein 71 (RNF71) or tripartite motif-containing protein 19 (TRIM19), is predominantly a nuclear protein with a broad intrinsic antiviral activity. It is the eponymous component of PML nuclear bodies (PML NBs) and has been implicated in a wide variety of cell processes, including DNA damage signaling, apoptosis, and transcription. PML interferes with the replication of many unrelated viruses, including human immunodeficiency virus 1 (HIV-1), human foamy virus (HFV), poliovirus, influenza virus, rabies virus, EMCV, adeno-associated virus (AAV), and vesicular stomatitis virus (VSV). It also selectively interacts with misfolded proteins through distinct substrate recognition sites and conjugates these proteins with the small ubiquitin-like modifiers (SUMOs) through its SUMO ligase activity. PML belongs to the C-V subclass of the TRIM (tripartite motif) family of proteins that are defined by an N-terminal RBCC (RING, Bbox, and coiled coil) domain, including three consecutive zinc-binding domains, a C3HC4-type RING-HC finger, Bbox1 and Bbox2, and a coiled coil region, as well as an uncharacterized region positioned C-terminal to the RBCC domain. Pssm-ID: 438241 [Multi-domain] Cd Length: 52 Bit Score: 36.38 E-value: 5.93e-03
|
||||||||
Tudor_TDRD15_rpt5 | cd20440 | fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ... |
1564-1626 | 7.37e-03 | ||||
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410511 Cd Length: 127 Bit Score: 38.21 E-value: 7.37e-03
|
||||||||
Tudor_TDRD8 | cd20430 | Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, ... |
1570-1611 | 7.44e-03 | ||||
Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 36.89 E-value: 7.44e-03
|
||||||||
Tudor_TDRD6_rpt5 | cd20424 | fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ... |
1022-1132 | 9.61e-03 | ||||
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Pssm-ID: 410495 Cd Length: 126 Bit Score: 37.87 E-value: 9.61e-03
|
||||||||
Blast search parameters | ||||
|