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Conserved domains on  [gi|1004697920|ref|XP_007444689|]
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zinc finger protein 501-like isoform X1 [Python bivittatus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 20-61 1.00e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.00e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1004697920  20 SVSFEEVAVYFTEEEWTLLDPSQRALHGEVMLENSRNVTTLG 61
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
126-351 3.73e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 3.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1004697920 126 TSSLAFHQNLYMKQKPctfLNSGKNFSLSSHLISNKEEKMYECGKSF----NKKQLLILPPKIPPREKPYKCLQCGKSFT 201
Cdd:COG5048   224 SSSLPLTTNSQLSPKS---LLSQSPSSLSSSDSSSSASESPRSSLPTassqSSSPNESDSSSEKGFSLPIKSKQCNISFS 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1004697920 202 QRGNLIIHER--IHTGE--KPYIC--LVCGRRFTRSGHLTRHKRIHTGEKPYKC--TECGKTFS------LRDSVMRHKR 267
Cdd:COG5048   301 RSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnePPQSLQQYKD 380

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1004697920 268 LHAREKSYKSM-ECGKSVTHSSQLACHKRIHTGEKP--YKCLECGKSFNKSSCLTYHKRVHTgEKPYKCTECEKSFSQNS 344
Cdd:COG5048   381 LKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDL 459


                  ....*..
gi 1004697920 345 HLTKHKR 351
Cdd:COG5048   460 DLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
345-370 5.36e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.36e-04
                          10        20
                  ....*....|....*....|....*.
gi 1004697920 345 HLTKHKRIHTGEKPYNCLECGKSFTY 370
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
401-426 1.12e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.12e-03
                          10        20
                  ....*....|....*....|....*.
gi 1004697920 401 HLTYHKRVHTGEKPYKCTECGKNFSQ 426
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
374-397 1.31e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|....
gi 1004697920 374 LIYHKRIHTGEKPYKCLECGKSFS 397
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 20-61 1.00e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.00e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1004697920  20 SVSFEEVAVYFTEEEWTLLDPSQRALHGEVMLENSRNVTTLG 61
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
21-86 6.70e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.94  E-value: 6.70e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1004697920   21 VSFEEVAVYFTEEEWTLLDPSQRALHGEVMLENSRNVTTLGYEqehenYKEPRiLVLQIHQREEKE 86
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ-----VPKPD-LISQLEQGEEPW 60
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 21-60 5.87e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.12  E-value: 5.87e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1004697920  21 VSFEEVAVYFTEEEWTLLDPSQRALHGEVMLENSRNVTTL 60
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
126-351 3.73e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 3.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1004697920 126 TSSLAFHQNLYMKQKPctfLNSGKNFSLSSHLISNKEEKMYECGKSF----NKKQLLILPPKIPPREKPYKCLQCGKSFT 201
Cdd:COG5048   224 SSSLPLTTNSQLSPKS---LLSQSPSSLSSSDSSSSASESPRSSLPTassqSSSPNESDSSSEKGFSLPIKSKQCNISFS 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1004697920 202 QRGNLIIHER--IHTGE--KPYIC--LVCGRRFTRSGHLTRHKRIHTGEKPYKC--TECGKTFS------LRDSVMRHKR 267
Cdd:COG5048   301 RSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnePPQSLQQYKD 380

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1004697920 268 LHAREKSYKSM-ECGKSVTHSSQLACHKRIHTGEKP--YKCLECGKSFNKSSCLTYHKRVHTgEKPYKCTECEKSFSQNS 344
Cdd:COG5048   381 LKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDL 459


                  ....*..
gi 1004697920 345 HLTKHKR 351
Cdd:COG5048   460 DLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
233-257 8.64e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 8.64e-05
                          10        20
                  ....*....|....*....|....*
gi 1004697920 233 HLTRHKRIHTGEKPYKCTECGKTFS 257
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
345-370 5.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.36e-04
                          10        20
                  ....*....|....*....|....*.
gi 1004697920 345 HLTKHKRIHTGEKPYNCLECGKSFTY 370
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
401-426 1.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.12e-03
                          10        20
                  ....*....|....*....|....*.
gi 1004697920 401 HLTYHKRVHTGEKPYKCTECGKNFSQ 426
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
374-397 1.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|....
gi 1004697920 374 LIYHKRIHTGEKPYKCLECGKSFS 397
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 383-437 2.06e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.06e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1004697920 383 GEKPYKC--LECGKSFSASSHLTYHKR-------------------VHTGEKPYKCTECGKNFsQNSNLMKHKRIH 437
Cdd:COG5189   346 DGKPYKCpvEGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRY-KNLNGLKYHRKH 420
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 20-61 1.00e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 81.75  E-value: 1.00e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1004697920  20 SVSFEEVAVYFTEEEWTLLDPSQRALHGEVMLENSRNVTTLG 61
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
21-86 6.70e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.94  E-value: 6.70e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1004697920   21 VSFEEVAVYFTEEEWTLLDPSQRALHGEVMLENSRNVTTLGYEqehenYKEPRiLVLQIHQREEKE 86
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ-----VPKPD-LISQLEQGEEPW 60
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 21-60 5.87e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.12  E-value: 5.87e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1004697920  21 VSFEEVAVYFTEEEWTLLDPSQRALHGEVMLENSRNVTTL 60
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
126-351 3.73e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 3.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1004697920 126 TSSLAFHQNLYMKQKPctfLNSGKNFSLSSHLISNKEEKMYECGKSF----NKKQLLILPPKIPPREKPYKCLQCGKSFT 201
Cdd:COG5048   224 SSSLPLTTNSQLSPKS---LLSQSPSSLSSSDSSSSASESPRSSLPTassqSSSPNESDSSSEKGFSLPIKSKQCNISFS 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1004697920 202 QRGNLIIHER--IHTGE--KPYIC--LVCGRRFTRSGHLTRHKRIHTGEKPYKC--TECGKTFS------LRDSVMRHKR 267
Cdd:COG5048   301 RSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnePPQSLQQYKD 380

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1004697920 268 LHAREKSYKSM-ECGKSVTHSSQLACHKRIHTGEKP--YKCLECGKSFNKSSCLTYHKRVHTgEKPYKCTECEKSFSQNS 344
Cdd:COG5048   381 LKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDL 459


                  ....*..
gi 1004697920 345 HLTKHKR 351
Cdd:COG5048   460 DLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
116-400 1.99e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 1.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1004697920 116 HQEHGQSISHTSSLAFHQNLYMKQKPCTFLNsgkNFSLSSHLISNKEEKMYECGKSFNKKQLLILPPKIPPREKPYKCLQ 195
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQN---LENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1004697920 196 CGKSFTQRGNLIIHERIHTG-EKPYICLVCGRRFTRSGHLTRHKR--IHTGE--KPYKCTE--CGKTFSLRDSVMRHKRL 268
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1004697920 269 H--AREKSYKSMECGKSVTHSSQLACHKRIHtgekpykcLECGKSFNKSSCLTYHKrvhtgekpykcteCEKSFSQNSHL 346
Cdd:COG5048   346 HtsISPAKEKLLNSSSKFSPLLNNEPPQSLQ--------QYKDLKNDKKSETLSNS-------------CIRNFKRDSNL 404

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1004697920 347 TKHKRIHTGEKPYNC--LECGKSFTYSSQLIYHKRIHTGEKPYKCLECGKSFSASS 400
Cdd:COG5048   405 SLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
77-437 1.42e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1004697920  77 LQIHQREEK--EKYLGCGKTGKETSDFTKHCTT--------QTKKEQYEHQEHGQSISHTSSLAFHQNLYMKQKPCTFLN 146
Cdd:COG5048    53 IRSHTGEKPsqCSYSGCDKSFSRPLELSRHLRThhnnpsdlNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSS 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1004697920 147 SG---KNFSLSSHLISNKEEKMYECGKSFNKKQLLILP-PKIPPREKPYKCLqcgksftqrgNLIIHERIHTGEKPYICL 222
Cdd:COG5048   133 RDpqlPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPlPANSLSKDPSSNL----------SLLISSNVSTSIPSSSEN 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1004697920 223 VCGRRFTRSGHLTRHKRIHTGEKPYKCTECgkTFSLRDSVMRHKRLHAReKSYKSMECGKSVTHSSQLACHKRIH----- 297
Cdd:COG5048   203 SPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLS-SSDSSSSASESPRSSLPTASSQSSSpnesd 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1004697920 298 -----TGEKPYKCLECGKSFNKSSCLTYHKR--VHTGE--KPYKCTE--CEKSFSQNSHLTKHKRIHTGEKPYNCLEC-- 364
Cdd:COG5048   280 sssekGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLns 359

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1004697920 365 -----GKSFTYSSQLIYHKRIHTGEKPYKCL--ECGKSFSASSHLTYHKRVHTGEKP--YKCTECGKNFSQNSNLMKHKR 435
Cdd:COG5048   360 sskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKK 439


                  ..
gi 1004697920 436 IH 437
Cdd:COG5048   440 IH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
189-439 1.61e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 1.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1004697920 189 KPYKCLQCGKSFTQRGNLIIHERIHTGEKPYICLVCGR--RFTRSGHLTRHKRIHTGEKPYKC----------------T 250
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNskslplsnskasssslS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1004697920 251 ECGKTFS----------------------LRDSVMRHKRLHA-------------REKSYKSMECGKSVTHSSQLACHKR 295
Cdd:COG5048   112 SSSSNSNdnnllsshslppssrdpqlpdlLSISNLRNNPLPGnnsssvntpqsnsLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1004697920 296 IHTGEKPYKCLECGKSFNKSSCLTYHKRVHTGEKPYKCTE----CEKSFSQNSHLTKHKRIHTGEKP--YNCLECGKSFT 369
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTnsqlSPKSLLSQSPSSLSSSDSSSSASesPRSSLPTASSQ 271

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1004697920 370 YSSQLIYHKRIHTG-EKPYKCLECGKSFSASSHLTYHKR--VHTGE--KPYKCTE--CGKNFSQNSNLMKHKRIHAG 439
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
233-257 8.64e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 8.64e-05
                          10        20
                  ....*....|....*....|....*
gi 1004697920 233 HLTRHKRIHTGEKPYKCTECGKTFS 257
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
345-370 5.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.36e-04
                          10        20
                  ....*....|....*....|....*.
gi 1004697920 345 HLTKHKRIHTGEKPYNCLECGKSFTY 370
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
318-342 7.48e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 7.48e-04
                          10        20
                  ....*....|....*....|....*
gi 1004697920 318 LTYHKRVHTGEKPYKCTECEKSFSQ 342
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
401-426 1.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.12e-03
                          10        20
                  ....*....|....*....|....*.
gi 1004697920 401 HLTYHKRVHTGEKPYKCTECGKNFSQ 426
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
374-397 1.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|....
gi 1004697920 374 LIYHKRIHTGEKPYKCLECGKSFS 397
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
293-314 2.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.00e-03
                          10        20
                  ....*....|....*....|..
gi 1004697920 293 HKRIHTGEKPYKCLECGKSFNK 314
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 383-437 2.06e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.06e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1004697920 383 GEKPYKC--LECGKSFSASSHLTYHKR-------------------VHTGEKPYKCTECGKNFsQNSNLMKHKRIH 437
Cdd:COG5189   346 DGKPYKCpvEGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRY-KNLNGLKYHRKH 420
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 415-437 2.65e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 2.65e-03
                          10        20
                  ....*....|....*....|...
gi 1004697920 415 YKCTECGKNFSQNSNLMKHKRIH 437
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 331-353 2.83e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 2.83e-03
                          10        20
                  ....*....|....*....|...
gi 1004697920 331 YKCTECEKSFSQNSHLTKHKRIH 353
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 327-406 3.07e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 3.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1004697920 327 GEKPYKC--TECEKSFsQNSHLTKHKRIHTgekpynclECGKSFTYSSQLIYHKRIHTGEKPYKCLECGKSFSASSHLTY 404
Cdd:COG5189   346 DGKPYKCpvEGCNKKY-KNQNGLKYHMLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1004697920 405 HK 406
Cdd:COG5189   417 HR 418
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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