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Conserved domains on  [gi|578838319|ref|XP_006724693|]
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ectodysplasin-A isoform X1 [Homo sapiens]

Protein Classification

TNF domain-containing protein( domain architecture ID 10075925)

TNF domain-containing protein similar to Homo sapiens lymphotoxin-alpha, which acts as cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TNF cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT ...
 249-380 3.13e-20

Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal domain, a short transmembrane segment, an extracellular stalk, and a globular TNF-like extracellular domain of about 150 residues. They initiate apoptosis by binding to related receptors, some of which have intracellular death domains. They generally form homo- or hetero- trimeric complexes.TNF cytokines bind one elongated receptor molecule along each of three clefts formed by neighboring monomers of the trimer with ligand trimerization a requiste for receptor binding.


:

Pssm-ID: 238108  Cd Length: 137  Bit Score: 85.86  E-value: 3.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838319 249 AVVHLQGQGSAIQVKNGGVLNDWSRITMNPkVFKLHPrsGELEVLVDGTYFIYSQVEVYYIN-FTDFASYEVVVDEK--- 324
Cdd:cd00184    1 PAAHLIGTNSSSGGTGLSWESDDGRAFLSG-GLELQN--GELVVPQDGLYYIYSQVYFRGQCcSTLSVSHVLQLRTDsyp 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578838319 325 PFLQCTRSIETGKT-----NYNTCYTAGVCLLKARQKIAVKmVHADISINMSKHTTFFGAI 380
Cdd:cd00184   78 EPILLLKGIRSVCSsvsegWYNSVYLGGLFQLRAGDRLSVN-VSAPALLDLSQGTTFFGAF 137
 
Name Accession Description Interval E-value
TNF cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT ...
 249-380 3.13e-20

Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal domain, a short transmembrane segment, an extracellular stalk, and a globular TNF-like extracellular domain of about 150 residues. They initiate apoptosis by binding to related receptors, some of which have intracellular death domains. They generally form homo- or hetero- trimeric complexes.TNF cytokines bind one elongated receptor molecule along each of three clefts formed by neighboring monomers of the trimer with ligand trimerization a requiste for receptor binding.


Pssm-ID: 238108  Cd Length: 137  Bit Score: 85.86  E-value: 3.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838319 249 AVVHLQGQGSAIQVKNGGVLNDWSRITMNPkVFKLHPrsGELEVLVDGTYFIYSQVEVYYIN-FTDFASYEVVVDEK--- 324
Cdd:cd00184    1 PAAHLIGTNSSSGGTGLSWESDDGRAFLSG-GLELQN--GELVVPQDGLYYIYSQVYFRGQCcSTLSVSHVLQLRTDsyp 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578838319 325 PFLQCTRSIETGKT-----NYNTCYTAGVCLLKARQKIAVKmVHADISINMSKHTTFFGAI 380
Cdd:cd00184   78 EPILLLKGIRSVCSsvsegWYNSVYLGGLFQLRAGDRLSVN-VSAPALLDLSQGTTFFGAF 137
TNF pfam00229
TNF(Tumour Necrosis Factor) family;
288-382 8.31e-05

TNF(Tumour Necrosis Factor) family;


Pssm-ID: 425540  Cd Length: 127  Bit Score: 41.92  E-value: 8.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838319  288 GELEVLVDGTYFIYSQVEVYYI----NFTDFASY-----EVVVDEKPFLQCTRSI---ETGKTNYNTCYTAGVCLLKARQ 355
Cdd:pfam00229  21 GELVVPQAGLYYVYSQVYFRGEgcpsGSVPLTHYlykfsSSYPGPVLLLKGAESPcssENPEYWYQSIYLGGLFELRAGD 100

                          90       100
                  ....*....|....*....|....*...
gi 578838319  356 KIAVKmVHADISINMSKH-TTFFGAIRL 382
Cdd:pfam00229 101 RLSVN-VSNPSLVDLSAPgKTYFGAFLL 127
 
Name Accession Description Interval E-value
TNF cd00184
Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT ...
 249-380 3.13e-20

Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal domain, a short transmembrane segment, an extracellular stalk, and a globular TNF-like extracellular domain of about 150 residues. They initiate apoptosis by binding to related receptors, some of which have intracellular death domains. They generally form homo- or hetero- trimeric complexes.TNF cytokines bind one elongated receptor molecule along each of three clefts formed by neighboring monomers of the trimer with ligand trimerization a requiste for receptor binding.


Pssm-ID: 238108  Cd Length: 137  Bit Score: 85.86  E-value: 3.13e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838319 249 AVVHLQGQGSAIQVKNGGVLNDWSRITMNPkVFKLHPrsGELEVLVDGTYFIYSQVEVYYIN-FTDFASYEVVVDEK--- 324
Cdd:cd00184    1 PAAHLIGTNSSSGGTGLSWESDDGRAFLSG-GLELQN--GELVVPQDGLYYIYSQVYFRGQCcSTLSVSHVLQLRTDsyp 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578838319 325 PFLQCTRSIETGKT-----NYNTCYTAGVCLLKARQKIAVKmVHADISINMSKHTTFFGAI 380
Cdd:cd00184   78 EPILLLKGIRSVCSsvsegWYNSVYLGGLFQLRAGDRLSVN-VSAPALLDLSQGTTFFGAF 137
TNF pfam00229
TNF(Tumour Necrosis Factor) family;
288-382 8.31e-05

TNF(Tumour Necrosis Factor) family;


Pssm-ID: 425540  Cd Length: 127  Bit Score: 41.92  E-value: 8.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838319  288 GELEVLVDGTYFIYSQVEVYYI----NFTDFASY-----EVVVDEKPFLQCTRSI---ETGKTNYNTCYTAGVCLLKARQ 355
Cdd:pfam00229  21 GELVVPQAGLYYVYSQVYFRGEgcpsGSVPLTHYlykfsSSYPGPVLLLKGAESPcssENPEYWYQSIYLGGLFELRAGD 100

                          90       100
                  ....*....|....*....|....*...
gi 578838319  356 KIAVKmVHADISINMSKH-TTFFGAIRL 382
Cdd:pfam00229 101 RLSVN-VSNPSLVDLSAPgKTYFGAFLL 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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