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Conserved domains on  [gi|578835489|ref|XP_006723662|]
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ral GTPase-activating protein subunit alpha-2 isoform X3 [Homo sapiens]

Protein Classification

GTPase-activating protein( domain architecture ID 20803145)

GTPase-activating protein functions as a GTPase activator for small GTPases, similar to Homo sapiens Ral GTPase-activating protein subunits, alpha-1 and alpha-2

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Rap_GAP pfam02145
Rap/ran-GAP;
1712-1884 2.83e-63

Rap/ran-GAP;


:

Pssm-ID: 460463  Cd Length: 179  Bit Score: 213.53  E-value: 2.83e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835489  1712 LSNERGSQAYEDFVAGLGWEVDLSTHCGFMGGLQR-NGSTGQTAPYYATSTVEVIFHVSTRMP-SDSDDSLTKKLRHLGN 1789
Cdd:pfam02145    1 LSNEEGSPAYEEFLNLLGWLVELKGFKGYRGGLDTkNNTTGEYSYYWADRGTEIMFHVSTLMPtTENDPQQLEKKRHIGN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835489  1790 DEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNH----MFFIAITKKPEVPFFGP-LFDGAIVSGKLLPSLVCATCIN 1864
Cdd:pfam02145   81 DIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPNLPDtdntLYRVSVVRKDDVPPFGPlLPDPKIFSKDNLPEFVRFLAIN 160
                          170       180
                   ....*....|....*....|
gi 578835489  1865 ASRAVkclipLYQSFYEERA 1884
Cdd:pfam02145  161 AERAA-----LKSSSFAERL 175
RALGAPB_N pfam20412
RALGAPB N-terminal domain; This putative domain is found at the N-terminus of the Ral ...
534-658 6.99e-34

RALGAPB N-terminal domain; This putative domain is found at the N-terminus of the Ral GTPase-activating protein beta subunit. The function of this region is not known.


:

Pssm-ID: 466561  Cd Length: 125  Bit Score: 127.05  E-value: 6.99e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835489   534 LLKEQVDACKAVLIIFRRMIME--LTMNKKTWEQMLQILLRITEAVMQKPKDKQikDLFAQSLAGLLFRTLMVAWIRANL 611
Cdd:pfam20412    1 LLEKQVDLCKRVLNIYRSIAREssLELEPETWEVLLKVLLGITDTLLRSPPIGP--DDLADELCEPLLQTLFEIWLRACL 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 578835489   612 CVYISRELWDDFLGVLSSLTEWEELINEWANIMDSLTAVLARTVYGV 658
Cdd:pfam20412   79 RCFPSPELWKTLKKLLSRWRHRPELIEQWNKVMLALTRRLLRLLYGP 125
 
Name Accession Description Interval E-value
Rap_GAP pfam02145
Rap/ran-GAP;
1712-1884 2.83e-63

Rap/ran-GAP;


Pssm-ID: 460463  Cd Length: 179  Bit Score: 213.53  E-value: 2.83e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835489  1712 LSNERGSQAYEDFVAGLGWEVDLSTHCGFMGGLQR-NGSTGQTAPYYATSTVEVIFHVSTRMP-SDSDDSLTKKLRHLGN 1789
Cdd:pfam02145    1 LSNEEGSPAYEEFLNLLGWLVELKGFKGYRGGLDTkNNTTGEYSYYWADRGTEIMFHVSTLMPtTENDPQQLEKKRHIGN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835489  1790 DEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNH----MFFIAITKKPEVPFFGP-LFDGAIVSGKLLPSLVCATCIN 1864
Cdd:pfam02145   81 DIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPNLPDtdntLYRVSVVRKDDVPPFGPlLPDPKIFSKDNLPEFVRFLAIN 160
                          170       180
                   ....*....|....*....|
gi 578835489  1865 ASRAVkclipLYQSFYEERA 1884
Cdd:pfam02145  161 AERAA-----LKSSSFAERL 175
RALGAPB_N pfam20412
RALGAPB N-terminal domain; This putative domain is found at the N-terminus of the Ral ...
534-658 6.99e-34

RALGAPB N-terminal domain; This putative domain is found at the N-terminus of the Ral GTPase-activating protein beta subunit. The function of this region is not known.


Pssm-ID: 466561  Cd Length: 125  Bit Score: 127.05  E-value: 6.99e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835489   534 LLKEQVDACKAVLIIFRRMIME--LTMNKKTWEQMLQILLRITEAVMQKPKDKQikDLFAQSLAGLLFRTLMVAWIRANL 611
Cdd:pfam20412    1 LLEKQVDLCKRVLNIYRSIAREssLELEPETWEVLLKVLLGITDTLLRSPPIGP--DDLADELCEPLLQTLFEIWLRACL 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 578835489   612 CVYISRELWDDFLGVLSSLTEWEELINEWANIMDSLTAVLARTVYGV 658
Cdd:pfam20412   79 RCFPSPELWKTLKKLLSRWRHRPELIEQWNKVMLALTRRLLRLLYGP 125
 
Name Accession Description Interval E-value
Rap_GAP pfam02145
Rap/ran-GAP;
1712-1884 2.83e-63

Rap/ran-GAP;


Pssm-ID: 460463  Cd Length: 179  Bit Score: 213.53  E-value: 2.83e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835489  1712 LSNERGSQAYEDFVAGLGWEVDLSTHCGFMGGLQR-NGSTGQTAPYYATSTVEVIFHVSTRMP-SDSDDSLTKKLRHLGN 1789
Cdd:pfam02145    1 LSNEEGSPAYEEFLNLLGWLVELKGFKGYRGGLDTkNNTTGEYSYYWADRGTEIMFHVSTLMPtTENDPQQLEKKRHIGN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835489  1790 DEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNH----MFFIAITKKPEVPFFGP-LFDGAIVSGKLLPSLVCATCIN 1864
Cdd:pfam02145   81 DIVNIVFNESGGPFDPSTIKSQFNHVFIVVQPNLPDtdntLYRVSVVRKDDVPPFGPlLPDPKIFSKDNLPEFVRFLAIN 160
                          170       180
                   ....*....|....*....|
gi 578835489  1865 ASRAVkclipLYQSFYEERA 1884
Cdd:pfam02145  161 AERAA-----LKSSSFAERL 175
RALGAPB_N pfam20412
RALGAPB N-terminal domain; This putative domain is found at the N-terminus of the Ral ...
534-658 6.99e-34

RALGAPB N-terminal domain; This putative domain is found at the N-terminus of the Ral GTPase-activating protein beta subunit. The function of this region is not known.


Pssm-ID: 466561  Cd Length: 125  Bit Score: 127.05  E-value: 6.99e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835489   534 LLKEQVDACKAVLIIFRRMIME--LTMNKKTWEQMLQILLRITEAVMQKPKDKQikDLFAQSLAGLLFRTLMVAWIRANL 611
Cdd:pfam20412    1 LLEKQVDLCKRVLNIYRSIAREssLELEPETWEVLLKVLLGITDTLLRSPPIGP--DDLADELCEPLLQTLFEIWLRACL 78
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 578835489   612 CVYISRELWDDFLGVLSSLTEWEELINEWANIMDSLTAVLARTVYGV 658
Cdd:pfam20412   79 RCFPSPELWKTLKKLLSRWRHRPELIEQWNKVMLALTRRLLRLLYGP 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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