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Conserved domains on  [gi|578832330|ref|XP_006722455|]
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tetratricopeptide repeat protein 39C isoform X4 [Homo sapiens]

Protein Classification

TTC39/IML2 family protein( domain architecture ID 706803)

TTC39/IML2 family protein is a DUF3808 domain-containing protein; similar to Saccharomyces cerevisiae inclusion body clearance protein IML2 involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as chaperone in inclusion clearing

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Iml2-TPR_39 super family cl28743
Iml2/Tetratricopeptide repeat protein 39; This is a family of proteins conserved from fungi to ...
 34-329 8.27e-100

Iml2/Tetratricopeptide repeat protein 39; This is a family of proteins conserved from fungi to humans, including fungal Inclusion body clearance protein Iml2 protein, animal tetratricopeptide repeat protein 39A/B/C (TT39A/B/C) and some uncharacterized proteins. Members of this family carry a tetratricopeptide repeat pfam07719 at their C terminus. This entry includes Iml2 and its paralogue-YKR018C from S. cerevisiae; Iml2 localizes to the cytoplasm and nucleus, and its expression is increased in response to DNA replication stress. It is found to be involved in lipid droplet-mediated inclusion body clearing after protein folding stress. In humans, TTC39A (also known as DEME6) is expressed in primary breast carcinomas but not in normal breast tissue, and has a putative eukaryotic RNP-1 RNA binding region and a candidate anchoring transmembrane domain. It is coordinately regulated with oestrogen receptor, but is not necessarily oestradiol-responsive. TTC39B has been linked to lipid metabolism.


The actual alignment was detected with superfamily member pfam10300:

Pssm-ID: 463047 [Multi-domain]  Cd Length: 469  Bit Score: 301.96  E-value: 8.27e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832330   34 LAGINMLLNNGFRESDQLFKQYRNHSPLMSFGASFVSFLNAMMTFEEEKMQLACDDLKTTEKLCE--SEEAGVIETIKNK 111
Cdd:pfam10300   1 LQALDLFLNNKFEEALELLKPWSKNSMYHALGYSVVAFIQAMLTFEPEDIQQASEALKEAEQVCQrfRKKAQVNESIQNT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832330  112 ikknvdvrkSAPSMVD-RLQRQIIIADCQVYLAVLSFVKQELSAYIKGGWILRKAWKIYNKCYLDINALQELYQKkltEE 190
Cdd:pfam10300  81 ---------DTSQLYEpGTHAEVCYAECLLLKAALTFQDESLVSFIKGGYKLRKAYQIYKECLKLINDPQQTKRS---SP 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832330  191 SLTSDAANDNhivaegVSEESLNRLKGAVSFGYGLFHLCISMVPPNLLKIINLLGFPGDRLQGLSSLMYASESKDMKAPL 270
Cdd:pfam10300 149 GDSSLSHNDN------NQAEIDEFFESGVNLGFGIFNLMLSLLPPRILKLLEFIGFSGDREDGLRLLWEASKSPNIRAAL 222

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578832330  271 ATLALLWYHTVVRPFFALDgsDNKAGLDEAKEILLKKEAAYPNSSLFMFFKGRIQRLEK 329
Cdd:pfam10300 223 ALLTLLFYYTGVRQVLGIP--GGEGPLEEAEALLLPYRKRYPNGALWLFFEARIESLKG 279
 
Name Accession Description Interval E-value
Iml2-TPR_39 pfam10300
Iml2/Tetratricopeptide repeat protein 39; This is a family of proteins conserved from fungi to ...
 34-329 8.27e-100

Iml2/Tetratricopeptide repeat protein 39; This is a family of proteins conserved from fungi to humans, including fungal Inclusion body clearance protein Iml2 protein, animal tetratricopeptide repeat protein 39A/B/C (TT39A/B/C) and some uncharacterized proteins. Members of this family carry a tetratricopeptide repeat pfam07719 at their C terminus. This entry includes Iml2 and its paralogue-YKR018C from S. cerevisiae; Iml2 localizes to the cytoplasm and nucleus, and its expression is increased in response to DNA replication stress. It is found to be involved in lipid droplet-mediated inclusion body clearing after protein folding stress. In humans, TTC39A (also known as DEME6) is expressed in primary breast carcinomas but not in normal breast tissue, and has a putative eukaryotic RNP-1 RNA binding region and a candidate anchoring transmembrane domain. It is coordinately regulated with oestrogen receptor, but is not necessarily oestradiol-responsive. TTC39B has been linked to lipid metabolism.


Pssm-ID: 463047 [Multi-domain]  Cd Length: 469  Bit Score: 301.96  E-value: 8.27e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832330   34 LAGINMLLNNGFRESDQLFKQYRNHSPLMSFGASFVSFLNAMMTFEEEKMQLACDDLKTTEKLCE--SEEAGVIETIKNK 111
Cdd:pfam10300   1 LQALDLFLNNKFEEALELLKPWSKNSMYHALGYSVVAFIQAMLTFEPEDIQQASEALKEAEQVCQrfRKKAQVNESIQNT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832330  112 ikknvdvrkSAPSMVD-RLQRQIIIADCQVYLAVLSFVKQELSAYIKGGWILRKAWKIYNKCYLDINALQELYQKkltEE 190
Cdd:pfam10300  81 ---------DTSQLYEpGTHAEVCYAECLLLKAALTFQDESLVSFIKGGYKLRKAYQIYKECLKLINDPQQTKRS---SP 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832330  191 SLTSDAANDNhivaegVSEESLNRLKGAVSFGYGLFHLCISMVPPNLLKIINLLGFPGDRLQGLSSLMYASESKDMKAPL 270
Cdd:pfam10300 149 GDSSLSHNDN------NQAEIDEFFESGVNLGFGIFNLMLSLLPPRILKLLEFIGFSGDREDGLRLLWEASKSPNIRAAL 222

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578832330  271 ATLALLWYHTVVRPFFALDgsDNKAGLDEAKEILLKKEAAYPNSSLFMFFKGRIQRLEK 329
Cdd:pfam10300 223 ALLTLLFYYTGVRQVLGIP--GGEGPLEEAEALLLPYRKRYPNGALWLFFEARIESLKG 279
 
Name Accession Description Interval E-value
Iml2-TPR_39 pfam10300
Iml2/Tetratricopeptide repeat protein 39; This is a family of proteins conserved from fungi to ...
 34-329 8.27e-100

Iml2/Tetratricopeptide repeat protein 39; This is a family of proteins conserved from fungi to humans, including fungal Inclusion body clearance protein Iml2 protein, animal tetratricopeptide repeat protein 39A/B/C (TT39A/B/C) and some uncharacterized proteins. Members of this family carry a tetratricopeptide repeat pfam07719 at their C terminus. This entry includes Iml2 and its paralogue-YKR018C from S. cerevisiae; Iml2 localizes to the cytoplasm and nucleus, and its expression is increased in response to DNA replication stress. It is found to be involved in lipid droplet-mediated inclusion body clearing after protein folding stress. In humans, TTC39A (also known as DEME6) is expressed in primary breast carcinomas but not in normal breast tissue, and has a putative eukaryotic RNP-1 RNA binding region and a candidate anchoring transmembrane domain. It is coordinately regulated with oestrogen receptor, but is not necessarily oestradiol-responsive. TTC39B has been linked to lipid metabolism.


Pssm-ID: 463047 [Multi-domain]  Cd Length: 469  Bit Score: 301.96  E-value: 8.27e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832330   34 LAGINMLLNNGFRESDQLFKQYRNHSPLMSFGASFVSFLNAMMTFEEEKMQLACDDLKTTEKLCE--SEEAGVIETIKNK 111
Cdd:pfam10300   1 LQALDLFLNNKFEEALELLKPWSKNSMYHALGYSVVAFIQAMLTFEPEDIQQASEALKEAEQVCQrfRKKAQVNESIQNT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832330  112 ikknvdvrkSAPSMVD-RLQRQIIIADCQVYLAVLSFVKQELSAYIKGGWILRKAWKIYNKCYLDINALQELYQKkltEE 190
Cdd:pfam10300  81 ---------DTSQLYEpGTHAEVCYAECLLLKAALTFQDESLVSFIKGGYKLRKAYQIYKECLKLINDPQQTKRS---SP 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578832330  191 SLTSDAANDNhivaegVSEESLNRLKGAVSFGYGLFHLCISMVPPNLLKIINLLGFPGDRLQGLSSLMYASESKDMKAPL 270
Cdd:pfam10300 149 GDSSLSHNDN------NQAEIDEFFESGVNLGFGIFNLMLSLLPPRILKLLEFIGFSGDREDGLRLLWEASKSPNIRAAL 222

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578832330  271 ATLALLWYHTVVRPFFALDgsDNKAGLDEAKEILLKKEAAYPNSSLFMFFKGRIQRLEK 329
Cdd:pfam10300 223 ALLTLLFYYTGVRQVLGIP--GGEGPLEEAEALLLPYRKRYPNGALWLFFEARIESLKG 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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