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Conserved domains on  [gi|578826798|ref|XP_006720524|]
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N-acetylgalactosamine kinase isoform X2 [Homo sapiens]

Protein Classification

galactokinase family protein( domain architecture ID 1004942)

galactokinase family protein such as galactokinase that catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

CATH:  1.20.1440.340|3.30.230.10|3.30.70.3170
EC:  2.7.1.-
Gene Ontology:  GO:0005524|GO:0004335|GO:0005975
PubMed:  26862196|15526155

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02521 super family cl33510
galactokinase
 18-448 3.78e-159

galactokinase


The actual alignment was detected with superfamily member PLN02521:

Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 459.56  E-value: 3.78e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  18 RLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTY-ALQLANTNPLYPDFSTSAN 96
Cdd:PLN02521  31 RYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSkKLRIANVNDKYTTCTFPAD 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  97 NIQ-IDKTKPLWHNYFLCGLKGIQEHFGLSN-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVE 170
Cdd:PLN02521 111 PDQeVDLANHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKE 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 171 LAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSH--FNIRVMECR 248
Cdd:PLN02521 191 VAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECR 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 249 LAAKLLA-KYKSLQWD---KVLRLEEVQaKLGISLEE------MLLVTEDALHPEPYNPEEICRCLGISLEELRTQilSP 318
Cdd:PLN02521 271 LAAIVLAvKLGMSAEEaisKVKTLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SP 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 319 NTQDVLI----FKLYQRAKHVYSEAARVLQFKKICEE--APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF 392
Cdd:PLN02521 348 TSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDN 427

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 393 GAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQ-RSD-GSLAPEKQSL--FATKP 448
Cdd:PLN02521 428 GALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEkGVIKEEDLGLyvFASKP 487
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 18-448 3.78e-159

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 459.56  E-value: 3.78e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  18 RLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTY-ALQLANTNPLYPDFSTSAN 96
Cdd:PLN02521  31 RYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSkKLRIANVNDKYTTCTFPAD 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  97 NIQ-IDKTKPLWHNYFLCGLKGIQEHFGLSN-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVE 170
Cdd:PLN02521 111 PDQeVDLANHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKE 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 171 LAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSH--FNIRVMECR 248
Cdd:PLN02521 191 VAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECR 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 249 LAAKLLA-KYKSLQWD---KVLRLEEVQaKLGISLEE------MLLVTEDALHPEPYNPEEICRCLGISLEELRTQilSP 318
Cdd:PLN02521 271 LAAIVLAvKLGMSAEEaisKVKTLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SP 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 319 NTQDVLI----FKLYQRAKHVYSEAARVLQFKKICEE--APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF 392
Cdd:PLN02521 348 TSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDN 427

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 393 GAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQ-RSD-GSLAPEKQSL--FATKP 448
Cdd:PLN02521 428 GALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEkGVIKEEDLGLyvFASKP 487
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
18-450 1.75e-86

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 269.33  E-value: 1.75e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  18 RLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLANTNplYPD-FSTSAN 96
Cdd:COG0153    1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSAD--FDEeVEFDLD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  97 NIQIDKTKPlWHNYFLcG-LKGIQEHfGLsNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEIC 175
Cdd:COG0153   79 DLEPGEEDG-WANYVR-GvAWALQER-GY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 176 AKSE-RYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKL 253
Cdd:COG0153  155 QRAEnEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAI 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 254 LAKykslqwdKVLRleEVqaklgiSLEEmllvtedalhpepynpeeicrclgisLEELRTQILSPntqdvlifKLYQRAK 333
Cdd:COG0153  234 LGV-------KSLR--DV------TLED--------------------------LEAARARLGDE--------VLRRRAR 264

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 334 HVYSEAARVLQFKKICEeapENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSMV 412
Cdd:COG0153  265 HVVTENQRVLEAVEALR---AGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALV 341

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 578826798 413 PADKLPSFLANVHKAYYQRsdGSLAPEkqsLFATKPGA 450
Cdd:COG0153  342 PKDAVDEFIEAVAEAYAEK--TGLEPD---FYVVKPSD 374
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 20-452 2.54e-79

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 251.28  E-value: 2.54e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798   20 LKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPV--KTYALQLANTNPLYPDFSTsanN 97
Cdd:TIGR00131   2 ESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRddKNVRIYLANADNKFAERSL---D 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798   98 IQIDKTKPL-WHNYFLCGLKGIQEHFGLSNLtGMNCLVDGNIPPSSGLSSSSALVCCAGlVTLTVLGRN--LSKVELAEI 174
Cdd:TIGR00131  79 LPLDGSEVSdWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVG-AVLQNMGHLplDSKQILLRI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  175 CAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKL 253
Cdd:TIGR00131 157 QVAENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANF 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  254 LAKykslqwdkvlrleevqaKLGISLEEMLlvtedalhPEPYNPeeicrclgislEELRTQILSPNTQdvlifklyQRAK 333
Cdd:TIGR00131 236 LAA-----------------TDKGALRDFM--------NEYFAR-----------YIARLTKMLPLVE--------ERAK 271

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  334 HVYSEAARVLQFKKICEEapENMVQlLGELMNQSHMSCRDMYECSCPELDQLVDICR-KFGAQGSRLTGAGWGGCTVSMV 412
Cdd:TIGR00131 272 HVVSENLRVLKAVKAMKD--NDFKQ-FGALMNESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVHLV 348

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 578826798  413 PADKLPSFLANVHKAYYQRSDgslAPEKQSLFATKPGASE 452
Cdd:TIGR00131 349 PNENVDKVRQAVADKYPKKTG---LELTFYVIVSKPGAGS 385
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 26-73 1.32e-21

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.51  E-value: 1.32e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 578826798   26 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEP 73
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 18-448 3.78e-159

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 459.56  E-value: 3.78e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  18 RLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTY-ALQLANTNPLYPDFSTSAN 96
Cdd:PLN02521  31 RYARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSkKLRIANVNDKYTTCTFPAD 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  97 NIQ-IDKTKPLWHNYFLCGLKGIQEHFGLSN-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVE 170
Cdd:PLN02521 111 PDQeVDLANHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKE 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 171 LAEICAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSH--FNIRVMECR 248
Cdd:PLN02521 191 VAQFTCKCERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECR 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 249 LAAKLLA-KYKSLQWD---KVLRLEEVQaKLGISLEE------MLLVTEDALHPEPYNPEEICRCLGISLEELRTQilSP 318
Cdd:PLN02521 271 LAAIVLAvKLGMSAEEaisKVKTLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SP 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 319 NTQDVLI----FKLYQRAKHVYSEAARVLQFKKICEE--APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF 392
Cdd:PLN02521 348 TSLAVLKaakhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDN 427

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 393 GAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQ-RSD-GSLAPEKQSL--FATKP 448
Cdd:PLN02521 428 GALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEkGVIKEEDLGLyvFASKP 487
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
18-450 1.75e-86

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 269.33  E-value: 1.75e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  18 RLLKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLANTNplYPD-FSTSAN 96
Cdd:COG0153    1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSAD--FDEeVEFDLD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  97 NIQIDKTKPlWHNYFLcG-LKGIQEHfGLsNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEIC 175
Cdd:COG0153   79 DLEPGEEDG-WANYVR-GvAWALQER-GY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 176 AKSE-RYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKL 253
Cdd:COG0153  155 QRAEnEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAI 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 254 LAKykslqwdKVLRleEVqaklgiSLEEmllvtedalhpepynpeeicrclgisLEELRTQILSPntqdvlifKLYQRAK 333
Cdd:COG0153  234 LGV-------KSLR--DV------TLED--------------------------LEAARARLGDE--------VLRRRAR 264

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 334 HVYSEAARVLQFKKICEeapENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSMV 412
Cdd:COG0153  265 HVVTENQRVLEAVEALR---AGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALV 341

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 578826798 413 PADKLPSFLANVHKAYYQRsdGSLAPEkqsLFATKPGA 450
Cdd:COG0153  342 PKDAVDEFIEAVAEAYAEK--TGLEPD---FYVVKPSD 374
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 20-452 2.54e-79

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 251.28  E-value: 2.54e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798   20 LKLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPV--KTYALQLANTNPLYPDFSTsanN 97
Cdd:TIGR00131   2 ESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRddKNVRIYLANADNKFAERSL---D 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798   98 IQIDKTKPL-WHNYFLCGLKGIQEHFGLSNLtGMNCLVDGNIPPSSGLSSSSALVCCAGlVTLTVLGRN--LSKVELAEI 174
Cdd:TIGR00131  79 LPLDGSEVSdWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVG-AVLQNMGHLplDSKQILLRI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  175 CAKSERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKL 253
Cdd:TIGR00131 157 QVAENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANF 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  254 LAKykslqwdkvlrleevqaKLGISLEEMLlvtedalhPEPYNPeeicrclgislEELRTQILSPNTQdvlifklyQRAK 333
Cdd:TIGR00131 236 LAA-----------------TDKGALRDFM--------NEYFAR-----------YIARLTKMLPLVE--------ERAK 271

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  334 HVYSEAARVLQFKKICEEapENMVQlLGELMNQSHMSCRDMYECSCPELDQLVDICR-KFGAQGSRLTGAGWGGCTVSMV 412
Cdd:TIGR00131 272 HVVSENLRVLKAVKAMKD--NDFKQ-FGALMNESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVHLV 348

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 578826798  413 PADKLPSFLANVHKAYYQRSDgslAPEKQSLFATKPGASE 452
Cdd:TIGR00131 349 PNENVDKVRQAVADKYPKKTG---LELTFYVIVSKPGAGS 385
PRK05322 PRK05322
galactokinase; Provisional
 21-428 3.84e-51

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 177.74  E-value: 3.84e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  21 KLKEMFNSKFGSIPK--FYvrAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLANTNplYPD---FSTSA 95
Cdd:PRK05322   5 ELKKKFAEVFGEEAEdvFF--SPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSAN--FEDlgiIEFDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  96 NNIQIDKtKPLWHNYFLCGLKGIQEHfGLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEIC 175
Cdd:PRK05322  81 DDLSFDK-EDDWANYPKGVLKFLQEA-GYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 176 AKSE-RYIGTEGGGMDQSISFLAEEGTAKLI-------EFSPLRATDVKLpsgavfVIANScvemNKA---ATSHFNIRV 244
Cdd:PRK05322 159 QKTEnEFIGVNSGIMDQFAIGMGKKDHAILLdcntleyEYVPLDLGDYVI------VIMNT----NKRrelADSKYNERR 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 245 MECRLAakllakykslqwdkvlrLEEVQAKLGI-SLEEmllVTEDAlhpepynpeeicrclgisLEELRTQILSPNtqdv 323
Cdd:PRK05322 229 AECEKA-----------------LEELQKKLDIkSLGE---LTEEE------------------FDEYSYLIKDET---- 266

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 324 lifkLYQRAKHVYSEAARVLQFKKICEeapENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGA 402
Cdd:PRK05322 267 ----LLKRARHAVTENQRTLKAVKALK---AGDLEKFGRLMNASHVSLRDDYEVTGLELDTLVEAAWKQeGVLGARMTGA 339

                        410       420
                 ....*....|....*....|....*.
gi 578826798 403 GWGGCTVSMVPADKLPSFLANVHKAY 428
Cdd:PRK05322 340 GFGGCAIAIVKKDKVEAFKENVGKAY 365
PRK05101 PRK05101
galactokinase; Provisional
 21-432 1.87e-50

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 175.50  E-value: 1.87e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  21 KLKEMFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEP-----VKTYALQLANtnpLYPDFSTSA 95
Cdd:PRK05101   6 KTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKrddriVRVIAADYDN---QQDEFSLDA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  96 nNIQIDKTKpLWHNYFLCGLKGIQEHfgLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEIC 175
Cdd:PRK05101  83 -PIVPHPEQ-QWANYVRGVVKHLQER--NPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEIALNG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 176 AKSE-RYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLL 254
Cdd:PRK05101 159 QEAEnQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMPEGVAVVIINSNVKRG-LVDSEYNTRRQQCETAARFF 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 255 AKykslqwdKVLR---LEEVQAKlgisleemllvtEDALHPEpynpeeicrclgisleelrtqilspntqdvlifkLYQR 331
Cdd:PRK05101 238 GV-------KALRdvtLEQFNAV------------AAELDPV----------------------------------VAKR 264

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 332 AKHVYSEAARVLQFKKICEEapENMVqLLGELMNQSHMSCRDMYECSCPELDQLVDICR-KFGAQGS-RLTGAGWGGCTV 409
Cdd:PRK05101 265 ARHVITENARTLEAASALAA--GDLK-RMGELMAESHASMRDDFEITVPQIDTLVEIVKaVIGDQGGvRMTGGGFGGCIV 341

                        410       420
                 ....*....|....*....|...
gi 578826798 410 SMVPADKLPSFLANVHKAYYQRS 432
Cdd:PRK05101 342 ALVPEELVEAVRQAVAEQYEAKT 364
PRK03817 PRK03817
galactokinase; Provisional
 38-431 2.87e-42

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 152.84  E-value: 2.87e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  38 VRAPGRVNIIGEHIDYC-GYsVLPMAVEQDVLIAVEPVKTYAlqlantnpLYPDFSTSANNIQIDKTKPL--WHNYFLCG 114
Cdd:PRK03817   3 VKSPGRVNLIGEHTDYNdGY-VLPFAINLYTFLEIEKSEKFI--------FYSENFNEEKTFELDKLEKLnsWADYIKGV 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 115 LKGIQEHFGlsNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSER-YIGTEGGGMDQSI 193
Cdd:PRK03817  74 IWVLEKRGY--EVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENeFVGVPCGIMDQFA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 194 SFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEmNKAATSHFNIRVMECRLAAKLLAKYKSLQwdkvlrleevqa 273
Cdd:PRK03817 152 VAFGKKDHAIFLDTMTLEYEYVPFPEDYEILVFDTGVK-RELASSEYNERRQECEEALKILGKKSSKE------------ 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 274 klgisleemllVTEDALHpepynpeeicrclgiSLEELrtqilspntqdvlifkLYQRAKHVYSEAARVLQFKKICEeap 353
Cdd:PRK03817 219 -----------VTEEDLS---------------KLPPL----------------LRKRAGYVLRENERVLKVRDALK--- 253

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578826798 354 ENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQR 431
Cdd:PRK03817 254 EGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALELGAYGARLTGAGFGGSAIALVDKGKFESIGEELLEEYKKR 331
PRK00555 PRK00555
galactokinase; Provisional
 40-427 3.79e-26

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 108.79  E-value: 3.79e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  40 APGRVNIIGEHIDY-CGYSvLPMAVEQDVLIAVEPVKTYALQLANtnplypDFSTSANNIQIDkTKPL----WHNYFLCG 114
Cdd:PRK00555   7 APGRINLIGEHTDYnLGFA-LPIALPQRTVVTFTPEHTDAITASS------DRADGSARIPLD-TTPGqvtgWAAYAAGV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 115 LKGIQEHFglSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSER-YIGTEGGGMDQSI 193
Cdd:PRK00555  79 IWALRGAG--HPVPGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATGTRIDRLEQARLAQRAENeYVGAPTGLLDQLA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 194 SFLAEEGTAKLIEFSPLRATDVKLPSGA--VFVIANSCVEMNKAATSHFNIRVMECRLAAKLLAkykslqwdkVLRLEEV 271
Cdd:PRK00555 157 ALFGAPKTALLIDFRDLTVRPVAFDPDAagVVLLLMDSRARHRHAGGEYAARRASCERAAADLG---------VSSLRAV 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 272 QAKLGISLeemllvtedalhpepynpeeicrclgisleelrTQILSPNTqdvlifklYQRAKHVYSEAARVLQFKKICEE 351
Cdd:PRK00555 228 QDRGLAAL---------------------------------GAIADPID--------ARRARHVLTENQRVLDFAAALAD 266

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578826798 352 APenmVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKA 427
Cdd:PRK00555 267 SD---FTAAGQLLTASHASMRDDFEITTERIDLIADSAVRAGALGARMTGGGFGGCVIALVPADRAEDVADTVRRA 339
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 26-73 1.32e-21

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.51  E-value: 1.32e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 578826798   26 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEP 73
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
PTZ00290 PTZ00290
galactokinase; Provisional
 1-431 4.70e-17

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 83.33  E-value: 4.70e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798   1 MATESPATRRVqvaeHPRLLKLKEMFNSKFGSIPK------FYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPV 74
Cdd:PTZ00290   1 MPAESYSDERL----DSTLSTLKPIFLETFKVENDadvewlLFTFAPGRVNFIGEHVDYMGGYVCPAAVLEGCHILVGRV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  75 KTYA---LQLANTNPLYpdfstsannIQIDKTKPLWHN----YFLCGLKGIQ-EHFGLS----NLTGMNCLVDGNIPPSS 142
Cdd:PTZ00290  77 KHFCdhkLRFATETDEH---------FVLDHLGGAKHNkawtTFVRGAATLRlNRLGVAidapSLQGVCMVVHGTLPMGA 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 143 GLSSSSAL-VCCAGLVTLTVLGR----------------NLSKVELAEIcAKSERYIGTEGGG-----MDQSISFLAEEG 200
Cdd:PTZ00290 148 GMSASASFgVALLNAINTVVTRRykgcptspgrrysilpPMSKEELIEL-AKQARRIETEFCGvnvgiMDQFISAFAEED 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 201 ----------TAKLIEFSPLratdvkLPSGAVFVIANSCVEMNkaatshfnirvmecrLAAKLLAKYKSLQWDkvlrLEE 270
Cdd:PTZ00290 227 kfmfldckslTFESHDMTPL------LGDGACFLLIDSMIKHD---------------LLGGTAGMYNTVRSD----QEG 281

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 271 VQAKLG--ISLEEMLLVTEDALHPEPY----NPEEIcrclgisLEELRTQiLSPNTqdvlifklYQRAKHVYSEAARVLQ 344
Cdd:PTZ00290 282 AQKKIGkhRYRGKPFTFSDLVRNPKKYtfdgDVVAF-------MESCKPL-MTPGE--------FERGTYNIMEQIRTLE 345

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 345 FKKICEEA----PENMVQLLGELMNQSHMSCRDMYECSCPELDQLVD-ICRKFGAQGSRLTGAGWGGCTVSMVPADKLPS 419
Cdd:PTZ00290 346 FIKLNDPElplsREERFRKAGEILNAGHQGMRDLMKITTPELDFIHElINEEKGVAGGRMMGGGFGGCIILLLKKNAVDR 425

                        490
                 ....*....|..
gi 578826798 420 FLANVHKAYYQR 431
Cdd:PTZ00290 426 VVAHVREKFKAR 437
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 40-407 3.42e-14

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 72.57  E-value: 3.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  40 APGRVNIIGEHID-YcGYSVLPMAVEQDVLIAVEPVKTYALQLantnplYPDFSTSANNIQIDKTKPLwhNYFLCGLKGI 118
Cdd:COG1577    1 APGKLILFGEHAVvY-GQPAIAVAVDRRATVTVEPSDDDKLRI------ESPDLGGTLDLDPLADAAL--RYIKAAIEAA 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 119 QEHFGLSNlTGMNCLVDGNIPPSsglssssalvccAGL-----VT-------LTVLGRNLSKVELAEICAKSERYIGTEG 186
Cdd:COG1577   72 LEYLGLPL-KGFDIEIDSEIPRK------------RGLgssaaVAvaviralAAFYGVELSKEELFKLALEAEKIVHGNP 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 187 GGMDQSISFLaeEGtakLIEF-SPLRATDVKLPSGAVFVIANSCVemnKAATSHfnirvmecrLAAKLLAKYKSlqwdkv 265
Cdd:COG1577  139 SGLDTAASTY--GG---PIYYqRGDRAEPLELPKNLPLVVGDTGV---PASTKE---------LVAKVRKLKER------ 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 266 lrleevqaklgisleemllvtedalHPEPYNPeeicrclgisleelrtqilspntqdvlifkLYQRAKHVYSEAARVLQf 345
Cdd:COG1577  196 -------------------------NPELYEA------------------------------FLEEIGDLVEEAIEALE- 219

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578826798 346 kkiceeapENMVQLLGELMNQSHmscRDMYE--CSCPELDQLVDICRKFGAQGSRLTGAGWGGC 407
Cdd:COG1577  220 --------EGDLEALGELMNENH---GLLRAlgVSTPELDRLVEAARKAGALGAKLTGAGGGGC 272
PLN02865 PLN02865
galactokinase
 38-453 2.71e-13

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 71.37  E-value: 2.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  38 VRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLAnTNPLYPDFSTSANNIQ------IDKTKP--LWHN 109
Cdd:PLN02865  33 VVSPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDPEVLLR-SAQFEGEVRFRVDEIQhpianvSSDSKEesNWGD 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 110 YFLCGLKGIQEhFGLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVT------LTVlgRNLSKVELAEICakSERYIG 183
Cdd:PLN02865 112 YARGAVYALQS-RGHALSQGITGYISGSEGLDSSGLSSSAAVGVAYLLAlenannLTV--SPEDNIELDRLI--ENEYLG 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 184 TEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAV-------FVIANSCVEMNKAATSHFNIRVMECRLAAKLLAK 256
Cdd:PLN02865 187 LRNGILDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQPggekpfkILLAFSGLRHALTNKPGYNLRVSECQEAARFLLE 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 257 YKSLqwdkvlrlEEVQAKLGisleemllvtedALHPEPYnpeeicrclgisleELRTQILSPNtqdvlifkLYQRAKHVY 336
Cdd:PLN02865 267 ASGN--------DELEPLLC------------NVEPEVY--------------EAHKCKLEAV--------LARRAEHYF 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 337 SEAARVLqfkKICEEAPENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSMVPAD 415
Cdd:PLN02865 305 SENMRVI---KGVEAWASGNLEEFGKLISASGLSSIENYECGCEPLIQLYEILLKApGVYGARFSGAGFRGCCVAFVDAE 381

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 578826798 416 KLPSFLANVhKAYYQRSDGSLA---PEKQSLFATKPGASER 453
Cdd:PLN02865 382 MAEEAASFV-RDEYEKAQPELAsniNGDKPVLICEAGDCAR 421
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 327-411 2.84e-11

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 64.49  E-value: 2.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 327 KLYQRAKHVYSEAARVLQfkkiceeapENMVQLLGELMNQSHMSCRDMyECSCPELDQLVDICRKFGAQGSRLTGAGWGG 406
Cdd:PTZ00298 218 RLLENYNACVSEAKEALQ---------KGNLFRVGELMNANHDLCQKL-TVSCRELDSIVQTCRTYGALGAKMSGTGRGG 287


                 ....*
gi 578826798 407 CTVSM 411
Cdd:PTZ00298 288 LVVAL 292
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 40-409 1.52e-10

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 61.54  E-value: 1.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798   40 APGRVNIIGEHIDYCGYSVLPMAVEQ-DVLIAVEPVKTYALQLANTNPLYPDFSTSANNIqidktkplwHNYFLCGLKgi 118
Cdd:TIGR00549   1 APGKIILFGEHAVVYGEPAIAAPIPLrTTVTVIESSDGSFIESDLGRGSLDDAPDELDGL---------KYVLAEFLS-- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  119 qeHFGLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSERYIGTEGGGMDQSISflae 198
Cdd:TIGR00549  70 --RFSELNPPPLEITIESEIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKIAHGKPSGIDTATS---- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  199 eGTAKLIEFSPLRATDVKLPS-GAVFVIANSCVEmnkaatshfnirvmecRLAAKLLAKYKSLqwdkvlrLEEvqaklgi 277
Cdd:TIGR00549 144 -TSGGPVYFEKGEGEFTKLISlDGYFVIADTGVS----------------GSTKEAVARVRQL-------LER------- 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  278 sleemllvtedalHPEpynpeeicrclgisleelrtqilspntqdvLIFKLYQRAKHVYSEAARVLQFKKiceeapenmV 357
Cdd:TIGR00549 193 -------------FPE------------------------------LIDSIMDAIGELTLEAKAALQDGD---------V 220

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 578826798  358 QLLGELMNQSHmSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTV 409
Cdd:TIGR00549 221 ESLGELMNINQ-GLLKALGVSHPKLDQLVEIARKAGALGAKLTGAGGGGCMI 271
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 350-430 1.47e-08

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 51.70  E-value: 1.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798  350 EEAPENMVQLLGELMNQSHMSC--RDMYECSCPELDQLVDICRKFGAqGSRLTGAGWGGCTVSMVP-ADKLPSFLANVHK 426
Cdd:pfam08544   3 EALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELGL-GAKLSGSGGGPTVFALFKdEDDAEEVARALRE 81


                  ....
gi 578826798  427 AYYQ 430
Cdd:pfam08544  82 AGKK 85
PRK03926 PRK03926
mevalonate kinase; Provisional
 360-416 1.90e-08

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 55.44  E-value: 1.90e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 578826798 360 LGELMNQSHmSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADK 416
Cdd:PRK03926 216 LGELMNINQ-GLLDALGVSTKELSELIYAARTAGALGAKITGAGGGGCMVALAAPEK 271
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 330-439 1.10e-05

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 47.10  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578826798 330 QRAKHVYSEAARVLQFKKICEEApENMVQLL--------GELMNQSHMSCRDMYE-CSCPELDQLVDICRKFGAQGSRLT 400
Cdd:COG2605  205 QVKNVEDGDEATLEALHEMKELA-LEMKEALlkgdldefGELLNEGWELKKRLASgISNPAIDEIYELARKAGALGGKLL 283

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 578826798 401 GAGWGGCTVSMVPADKLPSFLANVHKAYYQRSDGSLAPE 439
Cdd:COG2605  284 GAGGGGFLLFYAPPERREAVREALSKAGLRVVPFSFDKE 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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