NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|578825658|ref|XP_006720157|]
View 

kelch domain-containing protein 2 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
78-337 3.02e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 86.36  E-value: 3.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658  78 WKKInteGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSrSTDRvlqWERIDcqGIPPSSKDKLGVWVYKNKL 157
Cdd:COG3055    3 WSSL---PDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDP-ATNT---WSELA--PLPGPPRHHAAAVAQDGKL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658 158 IFFGGYgylpedkvlgtfefdeTSFWNSSHPRgwnDHVHILDTETFTWSQpitTGKAPSPRAAHACATVGNRGFVFGGRY 237
Cdd:COG3055   74 YVFGGF----------------TGANPSSTPL---NDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWD 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658 238 RDARMNDLHYLNLDTWEWNELIPqgiCPVGRSWHSLTPVSSDHLFLFGGFttDKQPLSDAWTycisknewIQFNHPYtek 317
Cdd:COG3055  132 DGGNVAWVEVYDPATGTWTQLAP---LPTPRDHLAAAVLPDGKILVIGGR--NGSGFSNTWT--------TLAPLPT--- 195

                        250       260
                 ....*....|....*....|
gi 578825658 318 PRLWHTACASDeGEVIVFGG 337
Cdd:COG3055  196 ARAGHAAAVLG-GKILVFGG 214
Kelch_4 pfam13418
Galactose oxidase, central domain;
32-89 1.74e-03

Galactose oxidase, central domain;


:

Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.05  E-value: 1.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578825658   32 RSGHVAVSDGRHM-FVWGGYKSNQVRgLYDfylpreeLWIYNMETGRWKKInteGDVPP 89
Cdd:pfam13418   2 RAYHTSTSIPDDTiYLFGGEGEDGTL-LSD-------LWVFDLSTNEWTRL---GSLPS 49
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
78-337 3.02e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 86.36  E-value: 3.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658  78 WKKInteGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSrSTDRvlqWERIDcqGIPPSSKDKLGVWVYKNKL 157
Cdd:COG3055    3 WSSL---PDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDP-ATNT---WSELA--PLPGPPRHHAAAVAQDGKL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658 158 IFFGGYgylpedkvlgtfefdeTSFWNSSHPRgwnDHVHILDTETFTWSQpitTGKAPSPRAAHACATVGNRGFVFGGRY 237
Cdd:COG3055   74 YVFGGF----------------TGANPSSTPL---NDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWD 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658 238 RDARMNDLHYLNLDTWEWNELIPqgiCPVGRSWHSLTPVSSDHLFLFGGFttDKQPLSDAWTycisknewIQFNHPYtek 317
Cdd:COG3055  132 DGGNVAWVEVYDPATGTWTQLAP---LPTPRDHLAAAVLPDGKILVIGGR--NGSGFSNTWT--------TLAPLPT--- 195

                        250       260
                 ....*....|....*....|
gi 578825658 318 PRLWHTACASDeGEVIVFGG 337
Cdd:COG3055  196 ARAGHAAAVLG-GKILVFGG 214
PLN02193 PLN02193
nitrile-specifier protein
 29-296 1.33e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 68.44  E-value: 1.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658  29 PAERSGHVAVSDGRHMFVWGG-YKSNQvrglydfylPREE-LWIYNMETGRWKKINTEGDVPP-SMSGSCAVCVDRVLYL 105
Cdd:PLN02193 163 PGLRCSHGIAQVGNKIYSFGGeFTPNQ---------PIDKhLYVFDLETRTWSISPATGDVPHlSCLGVRMVSIGSTLYV 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658 106 FGGHHSRGNTNKFYMLDSRSTdrvlQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNS 185
Cdd:PLN02193 234 FGGRDASRQYNGFYSFDTTTN----EWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHC 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658 186 SHP----------------------RGWN----DHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGryrD 239
Cdd:PLN02193 310 STPgdsfsirggaglevvqgkvwvvYGFNgcevDDVHYYDPVQDKWTQVETFGVRPSERSVFASAAVGKHIVIFGG---E 386

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578825658 240 ARMNDLHY------------LNLDTWEWNELIPQGI---CPVGRSWHSLTPVSSD---HLFLFGGfttdKQPLSD 296
Cdd:PLN02193 387 IAMDPLAHvgpgqltdgtfaLDTETLQWERLDKFGEeeeTPSSRGWTASTTGTIDgkkGLVMHGG----KAPTND 457
Kelch_4 pfam13418
Galactose oxidase, central domain;
267-307 1.14e-07

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 47.61  E-value: 1.14e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 578825658  267 GRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEW 307
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDGTLLSDLWVFDLSTNEW 41
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 48-157 1.19e-04

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 43.12  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658   48 GGYKsnqVRGLYDFYLPR--EELWIYNMETGRWKKIntEGDVPPSMSGSCAVCVDRVLYLFGghhSRGNTNKFYMLDS-- 123
Cdd:TIGR01640  53 KQYK---VLCFSDRSGNRnqSEHQVYTLGSNSWRTI--ECSPPHHPLKSRGVCINGVLYYLA---YTLKTNPDYFIVSfd 124

                          90       100       110
                  ....*....|....*....|....*....|....
gi 578825658  124 RSTDRVLQWERIDCqgIPPSSKDKLGVWVYKNKL 157
Cdd:TIGR01640 125 VSSERFKEFIPLPC--GNSDSVDYLSLINYKGKL 156
Kelch_4 pfam13418
Galactose oxidase, central domain;
32-89 1.74e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.05  E-value: 1.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578825658   32 RSGHVAVSDGRHM-FVWGGYKSNQVRgLYDfylpreeLWIYNMETGRWKKInteGDVPP 89
Cdd:pfam13418   2 RAYHTSTSIPDDTiYLFGGEGEDGTL-LSD-------LWVFDLSTNEWTRL---GSLPS 49
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
78-337 3.02e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 86.36  E-value: 3.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658  78 WKKInteGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSrSTDRvlqWERIDcqGIPPSSKDKLGVWVYKNKL 157
Cdd:COG3055    3 WSSL---PDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDP-ATNT---WSELA--PLPGPPRHHAAAVAQDGKL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658 158 IFFGGYgylpedkvlgtfefdeTSFWNSSHPRgwnDHVHILDTETFTWSQpitTGKAPSPRAAHACATVGNRGFVFGGRY 237
Cdd:COG3055   74 YVFGGF----------------TGANPSSTPL---NDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWD 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658 238 RDARMNDLHYLNLDTWEWNELIPqgiCPVGRSWHSLTPVSSDHLFLFGGFttDKQPLSDAWTycisknewIQFNHPYtek 317
Cdd:COG3055  132 DGGNVAWVEVYDPATGTWTQLAP---LPTPRDHLAAAVLPDGKILVIGGR--NGSGFSNTWT--------TLAPLPT--- 195

                        250       260
                 ....*....|....*....|
gi 578825658 318 PRLWHTACASDeGEVIVFGG 337
Cdd:COG3055  196 ARAGHAAAVLG-GKILVFGG 214
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
204-345 1.82e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 75.58  E-value: 1.82e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658 204 TWSqpiTTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPqgiCPVGRSWHSLTPVSSDHLFL 283
Cdd:COG3055    2 TWS---SLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAP---LPGPPRHHAAAVAQDGKLYV 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578825658 284 FGGFTTDK---QPLSDAWTYCISKNEWIQfnHPYTEKPRLWHTAcASDEGEVIVFGGCANNLLVH 345
Cdd:COG3055   76 FGGFTGANpssTPLNDVYVYDPATNTWTK--LAPMPTPRGGATA-LLLDGKIYVVGGWDDGGNVA 137
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
30-298 3.22e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 69.03  E-value: 3.22e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658  30 AERSGHVAVSDGRHMFVWGGYksnqvRGLYDFYLPREELWIYNMETGRWKKInteGDVPPSMSGSCAVCVDRVLYLFGGH 109
Cdd:COG3055   59 PPRHHAAAVAQDGKLYVFGGF-----TGANPSSTPLNDVYVYDPATNTWTKL---APMPTPRGGATALLLDGKIYVVGGW 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658 110 HSRGNTNKFYMLDsRSTDrvlQWERIdcqGIPPSSKDKL-GVWVYKNKLIFFGGYgylpedkvlgtfefDETSFWNsshp 188
Cdd:COG3055  131 DDGGNVAWVEVYD-PATG---TWTQL---APLPTPRDHLaAAVLPDGKILVIGGR--------------NGSGFSN---- 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658 189 rgwndhvhildtetfTWSqpiTTGKAPSPRAAHACATVGNRGFVFGGRYrdARMNDLHYLNLDTWEWNELipqGICPVGR 268
Cdd:COG3055  186 ---------------TWT---TLAPLPTARAGHAAAVLGGKILVFGGES--GFSDEVEAYDPATNTWTAL---GELPTPR 242

                        250       260       270
                 ....*....|....*....|....*....|.
gi 578825658 269 swHSLTPVS-SDHLFLFGGFTTDKQPLSDAW 298
Cdd:COG3055  243 --HGHAAVLtDGKVYVIGGETKPGVRTPLVT 271
PLN02193 PLN02193
nitrile-specifier protein
 29-296 1.33e-12

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 68.44  E-value: 1.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658  29 PAERSGHVAVSDGRHMFVWGG-YKSNQvrglydfylPREE-LWIYNMETGRWKKINTEGDVPP-SMSGSCAVCVDRVLYL 105
Cdd:PLN02193 163 PGLRCSHGIAQVGNKIYSFGGeFTPNQ---------PIDKhLYVFDLETRTWSISPATGDVPHlSCLGVRMVSIGSTLYV 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658 106 FGGHHSRGNTNKFYMLDSRSTdrvlQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNS 185
Cdd:PLN02193 234 FGGRDASRQYNGFYSFDTTTN----EWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHC 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658 186 SHP----------------------RGWN----DHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGryrD 239
Cdd:PLN02193 310 STPgdsfsirggaglevvqgkvwvvYGFNgcevDDVHYYDPVQDKWTQVETFGVRPSERSVFASAAVGKHIVIFGG---E 386

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578825658 240 ARMNDLHY------------LNLDTWEWNELIPQGI---CPVGRSWHSLTPVSSD---HLFLFGGfttdKQPLSD 296
Cdd:PLN02193 387 IAMDPLAHvgpgqltdgtfaLDTETLQWERLDKFGEeeeTPSSRGWTASTTGTIDgkkGLVMHGG----KAPTND 457
PLN02193 PLN02193
nitrile-specifier protein
 131-313 1.04e-10

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 62.67  E-value: 1.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658 131 QWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYgYLPEDKVlgtfefdetsfwnsshprgwNDHVHILDTETFTWSQPIT 210
Cdd:PLN02193 152 KWIKVEQKGEGPGLRCSHGIAQVGNKIYSFGGE-FTPNQPI--------------------DKHLYVFDLETRTWSISPA 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658 211 TGKAPSPRAAHAC-ATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTpVSSDHLFLFGGFT- 288
Cdd:PLN02193 211 TGDVPHLSCLGVRmVSIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMA-ADEENVYVFGGVSa 289

                        170       180
                 ....*....|....*....|....*
gi 578825658 289 TDKQPLSDAwtYCISKNEWIQFNHP 313
Cdd:PLN02193 290 TARLKTLDS--YNIVDKKWFHCSTP 312
PLN02153 PLN02153
epithiospecifier protein
 29-303 2.88e-10

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 60.77  E-value: 2.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658  29 PAERSGHVAVSDGRHMFVWGG-YKSNQVRGlydfylprEELWIYNMETGRWKKINTEGDVPP-SMSGSCAVCVDRVLYLF 106
Cdd:PLN02153  20 PGPRCSHGIAVVGDKLYSFGGeLKPNEHID--------KDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIF 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658 107 GGHHSRGNTNKFYMLDSRSTdrvlQWE---RIDCQGIPPS------SKDKLGVWVY----KNKL--------------IF 159
Cdd:PLN02153  92 GGRDEKREFSDFYSYDTVKN----EWTfltKLDEEGGPEArtfhsmASDENHVYVFggvsKGGLmktperfrtieaynIA 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658 160 FGGYGYLP------EDKVLGTFEFDETSFW------NSSHPRGWNDH----VHILDTETFTWSQPITTGKAPSPRAAHAC 223
Cdd:PLN02153 168 DGKWVQLPdpgenfEKRGGAGFAVVQGKIWvvygfaTSILPGGKSDYesnaVQFFDPASGKWTEVETTGAKPSARSVFAH 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658 224 ATVGNRGFVFGGR-YRDAR--------MNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSD---HLFLFGGFTTDK 291
Cdd:PLN02153 248 AVVGKYIIIFGGEvWPDLKghlgpgtlSNEGYALDTETLVWEKLGECGEPAMPRGWTAYTTATVYgknGLLMHGGKLPTN 327

                        330
                 ....*....|..
gi 578825658 292 QPLSDAWTYCIS 303
Cdd:PLN02153 328 ERTDDLYFYAVN 339
PLN02153 PLN02153
epithiospecifier protein
 212-337 1.78e-09

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 58.46  E-value: 1.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658 212 GKAPSPRAAHACATVGNRGFVFGGRYRDARM--NDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGfTT 289
Cdd:PLN02153  17 GKGPGPRCSHGIAVVGDKLYSFGGELKPNEHidKDLYVFDFNTHTWSIAPANGDVPRISCLGVRMVAVGTKLYIFGG-RD 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 578825658 290 DKQPLSDAWTYCISKNEW---IQFNHPYTEKPRLWHTAcASDEGEVIVFGG 337
Cdd:PLN02153  96 EKREFSDFYSYDTVKNEWtflTKLDEEGGPEARTFHSM-ASDENHVYVFGG 145
Kelch_4 pfam13418
Galactose oxidase, central domain;
267-307 1.14e-07

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 47.61  E-value: 1.14e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 578825658  267 GRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEW 307
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDGTLLSDLWVFDLSTNEW 41
PLN02193 PLN02193
nitrile-specifier protein
 205-337 1.29e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 53.04  E-value: 1.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658 205 WSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMND--LHYLNLDTWEWNELIPQGICPvGRSWHSLTPVS-SDHL 281
Cdd:PLN02193 153 WIKVEQKGEGPGLRCSHGIAQVGNKIYSFGGEFTPNQPIDkhLYVFDLETRTWSISPATGDVP-HLSCLGVRMVSiGSTL 231

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 578825658 282 FLFGGFTTDKQpLSDAWTYCISKNEWiQFNHPYTE--KPRLWHTAcASDEGEVIVFGG 337
Cdd:PLN02193 232 YVFGGRDASRQ-YNGFYSFDTTTNEW-KLLTPVEEgpTPRSFHSM-AADEENVYVFGG 286
PLN02153 PLN02153
epithiospecifier protein
 25-247 5.06e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 44.59  E-value: 5.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658  25 ELACPAERSGHVAVSDGRHMFVWGGYKSNqvrGLYDFYLPREELWIYNMETGRWKKINTEGDVPPSMSGS-CAVCVDRVL 103
Cdd:PLN02153 121 EEGGPEARTFHSMASDENHVYVFGGVSKG---GLMKTPERFRTIEAYNIADGKWVQLPDPGENFEKRGGAgFAVVQGKIW 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658 104 YLFG-------GHHSRGNTNKFYMLDSRSTdrvlQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGtfe 176
Cdd:PLN02153 198 VVYGfatsilpGGKSDYESNAVQFFDPASG----KWTEVETTGAKPSARSVFAHAVVGKYIIIFGGEVWPDLKGHLG--- 270

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578825658 177 fdetsfwnsshPRGWNDHVHILDTETFTWSQPITTGKAPSPRA--AHACATV-GNRGFVF-GGRY-RDARMNDLHY 247
Cdd:PLN02153 271 -----------PGTLSNEGYALDTETLVWEKLGECGEPAMPRGwtAYTTATVyGKNGLLMhGGKLpTNERTDDLYF 335
Kelch_3 pfam13415
Galactose oxidase, central domain;
279-326 9.97e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 39.58  E-value: 9.97e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 578825658  279 DHLFLFGGFTTDKQP-LSDAWTYCISKNEWIQFNHPYTekPRLWHTACA 326
Cdd:pfam13415   2 DKLYIFGGLGFDGQTrLNDLYVYDLDTNTWTQIGDLPP--PRSGHSATY 48
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
 48-157 1.19e-04

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 43.12  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658   48 GGYKsnqVRGLYDFYLPR--EELWIYNMETGRWKKIntEGDVPPSMSGSCAVCVDRVLYLFGghhSRGNTNKFYMLDS-- 123
Cdd:TIGR01640  53 KQYK---VLCFSDRSGNRnqSEHQVYTLGSNSWRTI--ECSPPHHPLKSRGVCINGVLYYLA---YTLKTNPDYFIVSfd 124

                          90       100       110
                  ....*....|....*....|....*....|....
gi 578825658  124 RSTDRVLQWERIDCqgIPPSSKDKLGVWVYKNKL 157
Cdd:TIGR01640 125 VSSERFKEFIPLPC--GNSDSVDYLSLINYKGKL 156
PHA03098 PHA03098
kelch-like protein; Provisional
 57-204 1.44e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.60  E-value: 1.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825658  57 GLYDFYLPREELWIYNMETGRWKKINTegdVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYMLDSRSTdRVLQWERID 136
Cdd:PHA03098 397 GISKNDELLKTVECFSLNTNKWSKGSP---LPISHYGGCAIYHDGKIYVIGGISYIDNIKVYNIVESYNP-VTNKWTELS 472

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578825658 137 CQGIPpssKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEfDETSFWNSSHprGWNDHVHILDTETFT 204
Cdd:PHA03098 473 SLNFP---RINASLCIFNNKIYVVGGDKYEYYINEIEVYD-DKTNTWTLFC--KFPKVIGSLEKNIFT 534
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 217-258 2.18e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.36  E-value: 2.18e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 578825658  217 PRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNEL 258
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKL 42
Kelch_3 pfam13415
Galactose oxidase, central domain;
227-274 1.41e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 36.11  E-value: 1.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 578825658  227 GNRGFVFGGRYRDA--RMNDLHYLNLDTWEWNELipqGICPVGRSWHSLT 274
Cdd:pfam13415   1 GDKLYIFGGLGFDGqtRLNDLYVYDLDTNTWTQI---GDLPPPRSGHSAT 47
Kelch_4 pfam13418
Galactose oxidase, central domain;
32-89 1.74e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.05  E-value: 1.74e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578825658   32 RSGHVAVSDGRHM-FVWGGYKSNQVRgLYDfylpreeLWIYNMETGRWKKInteGDVPP 89
Cdd:pfam13418   2 RAYHTSTSIPDDTiYLFGGEGEDGTL-LSD-------LWVFDLSTNEWTRL---GSLPS 49
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 29-76 6.02e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 34.08  E-value: 6.02e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 578825658   29 PAERSGHVAVSDGRHMFVWGGYKSNQVRGLYDFylpreelWIYNMETG 76
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEGQPSDDV-------YVLSLPTF 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH