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Conserved domains on  [gi|578825468|ref|XP_006720089|]
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adenylosuccinate synthetase isozyme 1 isoform X2 [Homo sapiens]

Protein Classification

adenylosuccinate synthetase( domain architecture ID 10464973)

GTP-dependent adenylosuccinate synthetase catalyzes the formation of adenylosuccinate from L-aspartate and IMP, the first step in the de novo biosynthesis of AMP

CATH:  1.10.300.10
EC:  6.3.4.4
Gene Ontology:  GO:0004019|GO:0005525|GO:0003688|GO:0000287
PubMed:  6347525|10218106
SCOP:  4003995

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
35-455 0e+00

Adenylosuccinate synthetase;


:

Pssm-ID: 459912  Cd Length: 417  Bit Score: 720.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468   35 VVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAE 114
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  115 KNEKKGLkDWEKRLIISDRAHLgdsgqqeAVDGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFS 194
Cdd:pfam00709  81 ELEERGI-DVPDRLFISDRAHLilp-yhkALDGLRE---EARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVFR 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  195 SRFKNLAHQHQSMFPTL---EIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFV 271
Cdd:pfam00709 155 EKLEALLELKNKLLEKLygePLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEG-KKILFEGAQGTLLDIDHGTYPYV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  272 TSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYA 351
Cdd:pfam00709 234 TSSNTTAGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYA 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  352 HMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYI 431
Cdd:pfam00709 314 VRINGVTGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYV 393

                         410       420
                  ....*....|....*....|....
gi 578825468  432 RFVENHVGVAVKWVGVGKSRESMI 455
Cdd:pfam00709 394 EFIEELLGVPIKIISVGPDREQTI 417
 
Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
35-455 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 720.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468   35 VVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAE 114
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  115 KNEKKGLkDWEKRLIISDRAHLgdsgqqeAVDGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFS 194
Cdd:pfam00709  81 ELEERGI-DVPDRLFISDRAHLilp-yhkALDGLRE---EARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVFR 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  195 SRFKNLAHQHQSMFPTL---EIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFV 271
Cdd:pfam00709 155 EKLEALLELKNKLLEKLygePLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEG-KKILFEGAQGTLLDIDHGTYPYV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  272 TSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYA 351
Cdd:pfam00709 234 TSSNTTAGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYA 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  352 HMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYI 431
Cdd:pfam00709 314 VRINGVTGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYV 393

                         410       420
                  ....*....|....*....|....
gi 578825468  432 RFVENHVGVAVKWVGVGKSRESMI 455
Cdd:pfam00709 394 EFIEELLGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 33-455 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 651.85  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468    33 VTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEE 112
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468   113 AEKNEKKGLkDWEKRLIISDRAHLGDSGQQEaVDglqevqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDE 192
Cdd:smart00788  81 IEELEAKGV-DVKDRLFISDRAHLILPYHIA-LD-------KAREKARIGTTGRGIGPAYEDKVARRGIRVGDLF-DEEV 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468   193 FSSRFKNLAHQHQSMFPTL----EIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTY 268
Cdd:smart00788 151 LREKLEELLDYKNFLLKKLygaePVDVEEILEELLEYAERLRPYVTDVSELLNEALKAG-KKVLFEGAQGTLLDIDHGTY 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468   269 PFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMIL 348
Cdd:smart00788 230 PYVTSSNTTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLL 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468   349 RYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQ 428
Cdd:smart00788 310 RYAVRINGITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAK 389

                          410       420
                   ....*....|....*....|....*..
gi 578825468   429 NYIRFVENHVGVAVKWVGVGKSRESMI 455
Cdd:smart00788 390 KYIERIEELVGVPVSIISTGPDREQTI 416
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 30-455 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 614.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  30 GSRVTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGL 109
Cdd:PTZ00350  11 KSKVVVILGAQWGDEGKGKLVDILSEKADIVARFNGGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHLPSL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 110 FEEAEKNEKKGlKDWEKRLIISDRAHLGDSGQQeAVDGLQEvQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsD 189
Cdd:PTZ00350  91 LEEIEQLTKKG-INLLGRLYISDRAHLVFDLHQ-AIDGIQE-SEKGKGGTQIGTTKRGIGPCYSTKASRTGLRVGDLL-N 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 190 FDEFSSRFKNLAHQHQSMFPTLEIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTYP 269
Cdd:PTZ00350 167 FETFEKKYRKLVEKLQEQYNIEEYDAEEELERYKGYAEKLKDMIVDTVYFMNKAIK-EGKRVLVEGANATMLDIDFGTYP 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 270 FVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILR 349
Cdd:PTZ00350 246 YVTSSNTTVGGVCTGLGIPPNAIILVIGVVKAYTTRVGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPALR 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 350 YAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGK--RIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQA 427
Cdd:PTZ00350 326 YVQMINGFDSINLTKLDVLSGLKEIKICVNYKNKGTglEIGRYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPENA 405

                        410       420
                 ....*....|....*....|....*...
gi 578825468 428 QNYIRFVENHVGVAVKWVGVGKSRESMI 455
Cdd:PTZ00350 406 QKYVLFIEELLGVPIVWIGVGPNRENMI 433
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 33-457 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 607.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  33 VTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEE 112
Cdd:COG0104    1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 113 AEKNEKKGLkDWEKRLIISDRAHLGDSGQQeAVDGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDE 192
Cdd:COG0104   81 IDGLEARGV-DVRSRLRISERAHLILPYHR-ALDKARE---EARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLL-DPEV 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 193 FSSRFKNLAHQHQSMFPTL----EIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALH-GppKKILVEGANAALLDIDFGT 267
Cdd:COG0104  155 LREKLEELLEYKNFLLEKLygaePLDFEELLEEYLEYAERLKPYVADTSELLNEALKaG--KKVLFEGAQGTLLDIDHGT 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 268 YPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMI 347
Cdd:COG0104  233 YPYVTSSNTTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAVA 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 348 LRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQA 427
Cdd:COG0104  313 LRYAVRINGLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPENA 392

                        410       420       430
                 ....*....|....*....|....*....|
gi 578825468 428 QNYIRFVENHVGVAVKWVGVGKSRESMIQL 457
Cdd:COG0104  393 RAYVERIEELLGVPISIVSVGPDREQTIVR 422
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 32-455 0e+00

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 508.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  32 RVTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFE 111
Cdd:cd03108    1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 112 EAEKNEKKGLkDWEKRLIISDRAHLGDSGQQEaVDGLQEVQRQaqeGKNIGTTKKGIGPTYSSKAARTGLRICDllsdfd 191
Cdd:cd03108   81 EIEELEKKGI-DVKGRLLISDRAHLVFPYHQE-LDGLEEKERG---GKKIGTTKRGIGPAYADKAARTGIRVGD------ 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 192 efssrfknlahqhqsmfptleidiegqlkrlkgfaerirPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTYPFV 271
Cdd:cd03108  150 ---------------------------------------PYVVDTVELLNEALK-AGKKVLFEGAQGTLLDIDFGTYPYV 189

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 272 TSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYA 351
Cdd:cd03108  190 TSSNTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYA 269

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 352 HMVNGFTALALTKLDIldvlgevkvgvsyklngkripyfpanqemlqkveveyetlpgwkadttgarrwedlppQAQNYI 431
Cdd:cd03108  270 VRINGLTELALTKLDV----------------------------------------------------------NAQKYI 291

                        410       420
                 ....*....|....*....|....
gi 578825468 432 RFVENHVGVAVKWVGVGKSRESMI 455
Cdd:cd03108  292 ERIEELLGVPITYISVGPDREQTI 315
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 35-457 5.15e-174

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 494.76  E-value: 5.15e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468   35 VVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAE 114
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEME 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  115 KNEKkGLKDWEKRLIISDRAHLGDSGQQEavdgLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLSD---FD 191
Cdd:TIGR00184  81 YLEK-RGISVRDRLFVSYRCHLILPYHKK----LDKAREKSKLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDeafAE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  192 EFSSRFKNLAHQHQSMFPTLEIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFV 271
Cdd:TIGR00184 156 KAKNILEYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEG-EKVLFEGAQGTMLDIDYGTYPYV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  272 TSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYA 351
Cdd:TIGR00184 235 TSSNTTAGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYA 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  352 HMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYI 431
Cdd:TIGR00184 315 CRLNGATQLALTKLDVLDGIDEIKVCVAYRMKGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYI 394

                         410       420
                  ....*....|....*....|....*.
gi 578825468  432 RFVENHVGVAVKWVGVGKSRESMIQL 457
Cdd:TIGR00184 395 ERIEELTGVPVTIISTGPEREQTIDL 420
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
33-356 1.09e-26

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 109.00  E-value: 1.09e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  33 VTVVLGAQWGDEGKGKVVDLLATDADIISRCQ-GGNNAGHTVVVD-GKEYDFHLLPSGI-INTKAVSFIGNGVVIHLPGL 109
Cdd:NF038379   1 VDVVVDGQFGSTGKGLIAGYLAERAAPDVVVRaAGPNAGHTYIDDeGRKFVHRMLPNGIvSPPLKQVLIGPGSEIDLEVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 110 FEEAEKNEKKGLkDWEKRLIISDRAHLgdsgqqeaVDGLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTglricdllsd 189
Cdd:NF038379  81 REEIEELEDAGH-DVGKRLLIHEQATV--------IELHKHVEEEAGPMTKIGSTKKGIGAARAAKIRRN---------- 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 190 fdefssrfknlahqhqsmfPTLEIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPPKKILVEGANAALLDIDFGTYP 269
Cdd:NF038379 142 -------------------PSTLGDAEGDFGEGAVRDQPWEIAERVVDNALYDFALQAAERIQIEGTQGYSLGLHAGFYP 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 270 FVTSSNCTVGGVCTGLGIPPQNI--GDVYGVVKAYTTRVGIGAFPT---------EQIneigGLLQtrghEWGVTTGRKR 338
Cdd:NF038379 203 YCTSRDCTPADFLADAGIPLPNVdaFKVVGTARTYPIRVAGWSGNSypdqgettwEEL----GLPE----ELTTVTKKVR 274

                        330
                 ....*....|....*...
gi 578825468 339 RCGWLDLMILRYAHMVNG 356
Cdd:NF038379 275 RVGTFSAEQVREAVQANG 292
 
Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
35-455 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 720.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468   35 VVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAE 114
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  115 KNEKKGLkDWEKRLIISDRAHLgdsgqqeAVDGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFS 194
Cdd:pfam00709  81 ELEERGI-DVPDRLFISDRAHLilp-yhkALDGLRE---EARGKKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVFR 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  195 SRFKNLAHQHQSMFPTL---EIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFV 271
Cdd:pfam00709 155 EKLEALLELKNKLLEKLygePLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEG-KKILFEGAQGTLLDIDHGTYPYV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  272 TSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYA 351
Cdd:pfam00709 234 TSSNTTAGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRYA 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  352 HMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYI 431
Cdd:pfam00709 314 VRINGVTGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKYV 393

                         410       420
                  ....*....|....*....|....
gi 578825468  432 RFVENHVGVAVKWVGVGKSRESMI 455
Cdd:pfam00709 394 EFIEELLGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 33-455 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 651.85  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468    33 VTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEE 112
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468   113 AEKNEKKGLkDWEKRLIISDRAHLGDSGQQEaVDglqevqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDE 192
Cdd:smart00788  81 IEELEAKGV-DVKDRLFISDRAHLILPYHIA-LD-------KAREKARIGTTGRGIGPAYEDKVARRGIRVGDLF-DEEV 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468   193 FSSRFKNLAHQHQSMFPTL----EIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTY 268
Cdd:smart00788 151 LREKLEELLDYKNFLLKKLygaePVDVEEILEELLEYAERLRPYVTDVSELLNEALKAG-KKVLFEGAQGTLLDIDHGTY 229

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468   269 PFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMIL 348
Cdd:smart00788 230 PYVTSSNTTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVLL 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468   349 RYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQ 428
Cdd:smart00788 310 RYAVRINGITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENAK 389

                          410       420
                   ....*....|....*....|....*..
gi 578825468   429 NYIRFVENHVGVAVKWVGVGKSRESMI 455
Cdd:smart00788 390 KYIERIEELVGVPVSIISTGPDREQTI 416
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 30-455 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 614.73  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  30 GSRVTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGL 109
Cdd:PTZ00350  11 KSKVVVILGAQWGDEGKGKLVDILSEKADIVARFNGGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHLPSL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 110 FEEAEKNEKKGlKDWEKRLIISDRAHLGDSGQQeAVDGLQEvQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsD 189
Cdd:PTZ00350  91 LEEIEQLTKKG-INLLGRLYISDRAHLVFDLHQ-AIDGIQE-SEKGKGGTQIGTTKRGIGPCYSTKASRTGLRVGDLL-N 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 190 FDEFSSRFKNLAHQHQSMFPTLEIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTYP 269
Cdd:PTZ00350 167 FETFEKKYRKLVEKLQEQYNIEEYDAEEELERYKGYAEKLKDMIVDTVYFMNKAIK-EGKRVLVEGANATMLDIDFGTYP 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 270 FVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILR 349
Cdd:PTZ00350 246 YVTSSNTTVGGVCTGLGIPPNAIILVIGVVKAYTTRVGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPALR 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 350 YAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGK--RIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQA 427
Cdd:PTZ00350 326 YVQMINGFDSINLTKLDVLSGLKEIKICVNYKNKGTglEIGRYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPENA 405

                        410       420
                 ....*....|....*....|....*...
gi 578825468 428 QNYIRFVENHVGVAVKWVGVGKSRESMI 455
Cdd:PTZ00350 406 QKYVLFIEELLGVPIVWIGVGPNRENMI 433
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 33-457 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 607.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  33 VTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEE 112
Cdd:COG0104    1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 113 AEKNEKKGLkDWEKRLIISDRAHLGDSGQQeAVDGLQEvqrQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDE 192
Cdd:COG0104   81 IDGLEARGV-DVRSRLRISERAHLILPYHR-ALDKARE---EARGKKKIGTTGRGIGPAYEDKVARRGIRVGDLL-DPEV 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 193 FSSRFKNLAHQHQSMFPTL----EIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALH-GppKKILVEGANAALLDIDFGT 267
Cdd:COG0104  155 LREKLEELLEYKNFLLEKLygaePLDFEELLEEYLEYAERLKPYVADTSELLNEALKaG--KKVLFEGAQGTLLDIDHGT 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 268 YPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMI 347
Cdd:COG0104  233 YPYVTSSNTTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAVA 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 348 LRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQA 427
Cdd:COG0104  313 LRYAVRINGLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPENA 392

                        410       420       430
                 ....*....|....*....|....*....|
gi 578825468 428 QNYIRFVENHVGVAVKWVGVGKSRESMIQL 457
Cdd:COG0104  393 RAYVERIEELLGVPISIVSVGPDREQTIVR 422
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 32-457 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 592.40  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  32 RVTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFE 111
Cdd:PRK01117   2 KNVVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALLK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 112 EAEKNEKKGLkDWEKRLIISDRAHLgdsgqqeAVDGLQEVQRqaqeGKN-IGTTKKGIGPTYSSKAARTGLRICDLLsDF 190
Cdd:PRK01117  82 EIDELEARGV-DVRERLRISERAHLilp-yhrALDKAREKAR----GKKkIGTTGRGIGPAYEDKVARRGIRVGDLL-DP 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 191 DEFSSRFKNLAHQH----QSMFPTLEIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALH-GppKKILVEGANAALLDIDF 265
Cdd:PRK01117 155 ETFAEKLEENLEYKnfllTKYYGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKaG--KRVLFEGAQGTLLDIDH 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 266 GTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDL 345
Cdd:PRK01117 233 GTYPFVTSSNTTAGGAATGSGVGPTKIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFDA 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 346 MILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPP 425
Cdd:PRK01117 313 VALRYAVRVNGLTGLALTKLDVLDGLEEIKICVAYELDGKRIDYFPASLEDLARCEPIYEELPGWSESTTGVRSFDDLPE 392

                        410       420       430
                 ....*....|....*....|....*....|..
gi 578825468 426 QAQNYIRFVENHVGVAVKWVGVGKSRESMIQL 457
Cdd:PRK01117 393 NARKYIKRIEELTGVPISIISTGPDRDQTIIL 424
PLN02513 PLN02513
adenylosuccinate synthase
 31-455 0e+00

adenylosuccinate synthase


Pssm-ID: 178129  Cd Length: 427  Bit Score: 575.05  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  31 SRVTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVV-VDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGL 109
Cdd:PLN02513   2 SQVSAVLGTQWGDEGKGKLVDILAQHFDIVARCQGGANAGHTIYnDEGKKFALHLVPSGILNEKTTCVIGNGVVVHLPGL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 110 FEEAEKNEKKGLkDWEKRLIISDRAHLGDSGQQEaVDGLQEVQRqaqEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsD 189
Cdd:PLN02513  82 FEEIDGLESNGV-SCEGRLLVSDRAHLLFDFHQE-VDGLREAEL---AGSKIGTTKRGIGPAYSSKATRNGLRVGDLR-H 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 190 FDEFSSRFKNLAHQHQSMFPTLEID---IEGQLKRLKGFAERIRPMVRDGVYFMYEAlHGPPKKILVEGANAALLDIDFG 266
Cdd:PLN02513 156 MDTFAEKLRELLADAAARFEGFEYDasmVEEEVEAYKKFAERLEPFITDTVHYLNEA-IQAGKKILVEGAQATMLDIDFG 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 267 TYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLM 346
Cdd:PLN02513 235 TYPFVTSSNPSAGGICTGLGIAPRKLGDIIGVVKAYTTRVGSGPFPTELFGELGDLLREAGQEFGTTTGRPRRCGWLDIV 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 347 ILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKL-NGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPP 425
Cdd:PLN02513 315 ALKYSCQINGFTSLNLTKLDVLSGLPEIKIGVAYKTpDGKVVKSFPADLDTLEQVEVVYEVLPGWQEDISSVRNYDDLPA 394

                        410       420       430
                 ....*....|....*....|....*....|
gi 578825468 426 QAQNYIRFVENHVGVAVKWVGVGKSRESMI 455
Cdd:PLN02513 395 AAQAYVERIEELVGVPVHYIGVGPGRDALI 424
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 32-455 0e+00

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 508.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  32 RVTVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFE 111
Cdd:cd03108    1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 112 EAEKNEKKGLkDWEKRLIISDRAHLGDSGQQEaVDGLQEVQRQaqeGKNIGTTKKGIGPTYSSKAARTGLRICDllsdfd 191
Cdd:cd03108   81 EIEELEKKGI-DVKGRLLISDRAHLVFPYHQE-LDGLEEKERG---GKKIGTTKRGIGPAYADKAARTGIRVGD------ 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 192 efssrfknlahqhqsmfptleidiegqlkrlkgfaerirPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTYPFV 271
Cdd:cd03108  150 ---------------------------------------PYVVDTVELLNEALK-AGKKVLFEGAQGTLLDIDFGTYPYV 189

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 272 TSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYA 351
Cdd:cd03108  190 TSSNTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRYA 269

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 352 HMVNGFTALALTKLDIldvlgevkvgvsyklngkripyfpanqemlqkveveyetlpgwkadttgarrwedlppQAQNYI 431
Cdd:cd03108  270 VRINGLTELALTKLDV----------------------------------------------------------NAQKYI 291

                        410       420
                 ....*....|....*....|....
gi 578825468 432 RFVENHVGVAVKWVGVGKSRESMI 455
Cdd:cd03108  292 ERIEELLGVPITYISVGPDREQTI 315
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 35-457 5.15e-174

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 494.76  E-value: 5.15e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468   35 VVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAE 114
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEME 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  115 KNEKkGLKDWEKRLIISDRAHLGDSGQQEavdgLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLSD---FD 191
Cdd:TIGR00184  81 YLEK-RGISVRDRLFVSYRCHLILPYHKK----LDKAREKSKLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDDeafAE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  192 EFSSRFKNLAHQHQSMFPTLEIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDFGTYPFV 271
Cdd:TIGR00184 156 KAKNILEYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEG-EKVLFEGAQGTMLDIDYGTYPYV 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  272 TSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYA 351
Cdd:TIGR00184 235 TSSNTTAGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAARYA 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  352 HMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQNYI 431
Cdd:TIGR00184 315 CRLNGATQLALTKLDVLDGIDEIKVCVAYRMKGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKKYI 394

                         410       420
                  ....*....|....*....|....*.
gi 578825468  432 RFVENHVGVAVKWVGVGKSRESMIQL 457
Cdd:TIGR00184 395 ERIEELTGVPVTIISTGPEREQTIDL 420
PRK13787 PRK13787
adenylosuccinate synthetase; Provisional
 34-457 1.00e-121

adenylosuccinate synthetase; Provisional


Pssm-ID: 172324  Cd Length: 423  Bit Score: 361.58  E-value: 1.00e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  34 TVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEA 113
Cdd:PRK13787   4 SLVVGTQWGDEGKAKVIDFLSKDTDIIVRYQGGANAGHTVVVHGKKYVFHLVPSGVIYDQTICVIGNGVVLDPLFFIEEC 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 114 EKNEKKGLKDWEKrLIISDRAHLGDSGQQEaVDGLQEVQrQAQEGKnIGTTKKGIGPTYSSKAARTGLRICDLLSDfdEF 193
Cdd:PRK13787  84 DRLQKEGFPVKDK-LLLSDACHLLFPYHSQ-IDSARETT-SSQEHK-IGTTKKGIGICYADKMMRTGLRVGDLLDK--SY 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 194 SSRFKNLAH-------QHQSMFPTLEIDIEgqlKRLKGFAERIRPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFG 266
Cdd:PRK13787 158 KRRLKHLVDeknreldKLYGMPPVSYNDIN---DGLKFFLSKVGKNIINTAYYLDTELK-KGKRVLLEGAQGTGLDVDFG 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 267 TYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLM 346
Cdd:PRK13787 234 TYPYVTSSNPTTGGALIGTGISFQHLKHVIGITKAYTTRVGEGPFPTELLGEAGEVLRQKGGEFGATTGRPRRCGWFDVE 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 347 ILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPAnqEMLQKVEVEYETLPGWKADTTGARRWEDLPPQ 426
Cdd:PRK13787 314 MLKHSVRINGITSIALTKIDILSDYDTIPVAVGYKLNGKTLDCFPS--QGLEKVEPLYEEFPGWKDDISGINEFQKLPEK 391

                        410       420       430
                 ....*....|....*....|....*....|.
gi 578825468 427 AQNYIRFVENHVGVAVKWVGVGKSRESMIQL 457
Cdd:PRK13787 392 CKNYISALEKWIGVKINLVSTGPDRKDTIIG 422
PRK13786 PRK13786
adenylosuccinate synthetase; Provisional
 34-456 1.91e-115

adenylosuccinate synthetase; Provisional


Pssm-ID: 184325  Cd Length: 424  Bit Score: 345.25  E-value: 1.91e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  34 TVVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVsFIGNGVVIHLPGLFEEA 113
Cdd:PRK13786   3 TIITGAQFGDEGKGKIVDLLAKDYDIVARFQGGDNAGHTVKVGDEVYKLHLIPSGFLLDARV-LIGPGVVLNPEVLAEEI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 114 EKNEKKGLKDWEKRLIISDRAHLGDSGQQEaVDGLQEVQRQAQegknIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEF 193
Cdd:PRK13786  82 DMLEKHGVKVDAEKLGIDAKTSIIMPYHIE-LDGLRESARTEK----IGTTKRGIGFAYIDKIARDEVRMSDLV-DKERL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 194 SSRFKNLAHQHQSMFPTLEIDI-----EGQLKRLKGFAERIRPMVRDGVYFMYEALHgPPKKILVEGANAALLDIDFGTY 268
Cdd:PRK13786 156 MRRLEELAPQKEKEIKELGGDPsivrdEALIDKYLELGRQLAPYITDVSYEINKALD-EGKSVLAEGAQGTHLDVIHGTQ 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 269 PFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMIL 348
Cdd:PRK13786 235 KFVTSSSTIAGSACANLGVGPTRVDNVLGIVKAYITRVGEGPLPTELKDEAGEHLQDVGGEFGTTTGRPRRCGWFDLPLL 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 349 RYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVEYETLPGWKADTTGARRWEDLPPQAQ 428
Cdd:PRK13786 315 KKAIYLNGYTEIALTKLDVLTGLDPIKICVGYELDGEILDYPPELTSDLARCVPVYEELEGWSTDLTEVKAYEDLPENAR 394

                        410       420
                 ....*....|....*....|....*...
gi 578825468 429 NYIRFVENHVGVAVKWVGVGKSRESMIQ 456
Cdd:PRK13786 395 NYVERLEELMGVPIKYISVGPGREQTFK 422
PRK13783 PRK13783
adenylosuccinate synthetase; Provisional
 35-457 2.94e-114

adenylosuccinate synthetase; Provisional


Pssm-ID: 237505  Cd Length: 404  Bit Score: 341.70  E-value: 2.94e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  35 VVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAE 114
Cdd:PRK13783   4 VIVGLQWGDEGKGKVVTYLSRYYDIVVRYSGGANAGHTVNYGDFKVVHHLLPSADFKKNVGAAIGNGVVLDLEVLVEELE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 115 KNEKKGlKDWEKRLIISDRAHLGDSGQQEaVDGLQEVQRqaqeGKNIGTTKKGIGPTYSSKAARTGLRICDLLSDfDEFS 194
Cdd:PRK13783  84 ELKEKF-PDYSGRIFISELAHVVLPVHKE-LDEIIESVR----KNAIGTTKRGIGPAYADKVMRVGVRLADLFDE-EKLR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 195 SRFKNLAHQHQSMFpTLEIDIEGQLKRLKGFAERIRPMVRDGVYfMYEALHGppKKILVEGANAALLDIDFGTYPFVTSS 274
Cdd:PRK13783 157 EFLEKILSLYKKLY-GIEFDVEKMMEDLLTFYEKIKDLVVSPVE-IKRILEE--KSVLFEGTQGVLLDLDVGTYPYVTSS 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 275 NCTVGGVCTGLGIPPQnIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLMILRYAHMV 354
Cdd:PRK13783 233 NCSTTGVSAGMGFPVK-VDEVIGVFKAYTTRVGEGPFPTELFGEEGEKLRKAGHEYGATTGRPRRCGWLDLPLLRYAIEV 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 355 NGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYfPANQEMLQKVEVEYETLPGWKadTTGARRWEDlppqaqnYIRFV 434
Cdd:PRK13783 312 SGVDSLVMTKADVLNGFEKIKVCVRYEIGGKEVRD-PSSLRDLEKAEPVYEEFDGWK--SLEDKNFLK-------FVDFI 381

                        410       420
                 ....*....|....*....|...
gi 578825468 435 ENHVGVAVKWVGVGKSRESMIQL 457
Cdd:PRK13783 382 ERETGRKIAYISTGPKIEEIVEV 404
PRK13788 PRK13788
adenylosuccinate synthetase; Provisional
 36-452 1.86e-111

adenylosuccinate synthetase; Provisional


Pssm-ID: 184326 [Multi-domain]  Cd Length: 404  Bit Score: 334.47  E-value: 1.86e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  36 VLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEK 115
Cdd:PRK13788   6 IIGAQWGDEGKGKVVDALAPEADFVVRYQGGANAGHTVVAKGKTFKLNLLPSGVLHPHATSVLGDGMVIDPFRFAEEREN 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 116 NEKKGLkdwEKRLIISDRAHLGDSgQQEAVDGlqevqrqaqeGKN-IGTTKKGIGPTYSSKAARTGLRICDLLSD--FDE 192
Cdd:PRK13788  86 LRAGGL---NPKLLISERAHLVLP-HHKYVDG----------RKNfVGTTGRGIGPAYSDRARRVGIRFGDLLDEavLRE 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 193 FSSRFknLAHQHQSMFPTLEIDIEGQLKRLKGFAERIRPMVRDGVYFMYEAL-HGppKKILVEGANAALLDIDFGTYPFV 271
Cdd:PRK13788 152 RVERL--LEAKPNSTREAGWDTVEKALADLAPMREILLPFIADTGSLLREAIrEG--KRVLFEGAQATLLDLNYGTYPYV 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 272 TSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRG----HEWGVTTGRKRRCGWLDLMI 347
Cdd:PRK13788 228 TSSHPTVGGILVGAGVNHKAINKVYGVAKAFTTRVGHGPFPTEVFGEMAIRLRGKGgnpwDEFGTTTGRARRVGWLDLVL 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 348 LRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKripyfpanqemlqkveVEYETLPGWkADTTGARRWEDLPPQA 427
Cdd:PRK13788 308 LKYACEVNGFDGLVLTKLDVLSGLEKVKVCVEYDDDGQ----------------PVYKELPGW-GDLDGVKSREALPKEA 370

                        410       420
                 ....*....|....*....|....*
gi 578825468 428 QNYIRFVENHVGVAVKWVGVGKSRE 452
Cdd:PRK13788 371 QAYLELIEETTGVPVVMFSTSPRRE 395
PRK13785 PRK13785
adenylosuccinate synthetase; Provisional
 33-457 1.23e-101

adenylosuccinate synthetase; Provisional


Pssm-ID: 237506  Cd Length: 454  Bit Score: 310.92  E-value: 1.23e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  33 VTVVlGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKaVSFIGNGVVIHLPGLFEE 112
Cdd:PRK13785   3 VTIV-GSQLGDEGKGGVVDLYGDAADVVVRYQGGDNAGHTVVHGGEEYKLSLVPSGAVRGK-IGVLGNGCVVNPETLFDE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 113 AEKNEKKGLkDWEKRliISDRAHLgDSGQQEAVDGLQEvQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDE 192
Cdd:PRK13785  81 IDALRERGL-DPDVR--VAERAHV-ILPYHRVLDGIEE-EAKSDSDLEVGTTGRGIGPTYEDKAGRRGVRVGDLL-DPDV 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 193 FSSRFKNLAHQHQSMFPTL----------EIDIEGQLKRLKGFAERIRP--MVRDGVYFMYEALHGPpKKILVEGANAAL 260
Cdd:PRK13785 155 LRDRLEYVVPQKRALAEDVygldasetpeAFDVDALFEEYREYGERLAEedMTVNAGDFLAERIDDG-DNVMLEGAQGTS 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 261 LDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGD--VYGVVKAYTTRVGIGAFPTE---------------QINEIGGLL 323
Cdd:PRK13785 234 IDIDHGNYPYVTSSNPTAGGAATGTGLGPTVVGQgeVVGIVKAYLSRVGSGPLPTElggvegdtpdeggrpDEEELATYI 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 324 QTRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIPYFPANQEMLQKVEVE 403
Cdd:PRK13785 314 REEGGEYGTVTGRPRRVGWLDMPMLRHAARASGFTGLAINHIDVLAGLDEVKVGHSYELDGEELLTMPATTERWARCEPN 393

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 578825468 404 YETLPGWKA---DTTGARRWEDLPPQAQNYIRFVENHVGVAVKWVGVGKSRESMIQL 457
Cdd:PRK13785 394 FRSFDGWPEvdwAAVAEEGYDALPENARTYLEYVSDELDTPIYAVGVGPGREETVVL 450
PRK13784 PRK13784
adenylosuccinate synthetase; Provisional
 35-455 2.88e-90

adenylosuccinate synthetase; Provisional


Pssm-ID: 172322  Cd Length: 428  Bit Score: 280.75  E-value: 2.88e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  35 VVLGAQWGDEGKGKVVDLLATDADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAE 114
Cdd:PRK13784   5 VIVGAQWGDEGKGKIADTLAEKADLVVRYQGGNNAGHTLVVNGKKTFLHLIPSGVLHQHTKCVIGHGVVLDPVALDEEIT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 115 KNEKKGLKDWEKRLIISDRAHLGDSGQQeavdgLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLsDFDEFS 194
Cdd:PRK13784  85 RLQAKGIAISAENLFVSESCTIITSYHK-----LLDAVRESNTSEKIGTTGKGIGPAYEDKVSRKGIKFKHLF-DKDLLR 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 195 SRFKNLAHQHQSMF--------PTLEIDIEgqlkRLKGFAERIRPMVRDGVYFMYEALhGPPKKILVEGANAALLDIDFG 266
Cdd:PRK13784 159 SRLAISLAEKETLFrdlykveyPTLEQEFD----KLFALGQKLKQYAADTFSIIDQAI-AAGKNVVYEGAQGVLLDVDYG 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 267 TYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGGLLQTRGHEWGVTTGRKRRCGWLDLM 346
Cdd:PRK13784 234 TYPFVTSSNTSVAGVYSGATTAGHGLDHVIGITKAYTTRVGEGPFPTELFDDVGKFIQHKGGEIGVTTGRIRRCGWLDLP 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 347 ILRYAHMVNGFTALALTKLDILDVLGEVKVGVSYKLNGKRIpYFPANQEMLQKVEVEYETLPGWKADTTGARrwEDLPPQ 426
Cdd:PRK13784 314 LLKYSAKCSNLTSIALTKVDVLSDMDTLKVCIGYKYEGKEI-YCAYPGIDLYKVEPILVEMEPFSIDETVTK--DNMPAA 390

                        410       420
                 ....*....|....*....|....*....
gi 578825468 427 AQNYIRFVENHVGVAVKWVGVGKSRESMI 455
Cdd:PRK13784 391 LKTYLKTIENHVGIPISSLAYGPSREQIL 419
PRK04293 PRK04293
adenylosuccinate synthetase; Provisional
 33-457 1.22e-61

adenylosuccinate synthetase; Provisional


Pssm-ID: 179812  Cd Length: 333  Bit Score: 203.57  E-value: 1.22e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  33 VTVVLGAQWGDEGKGKVVDLLA-TD-ADIISRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLF 110
Cdd:PRK04293   3 CTIVVGGFFGDEGKGKIIAYLAlKDkPSIIARGGVGPNAGHTVEYNGKKYGLRMIPSGFVNKDAKLAIGAGVLVDPEVLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 111 EEAEKNEKKGlkdwekRLIISDRAHLgdsgqqeavdgLQEVQRQAQEG-----KNIGTTKKGIGPTYSSKAARTGlricD 185
Cdd:PRK04293  83 KEVEELNVGG------RVFVDYRCGI-----------IEEKHVEEDRSdehlsKKIGSTGTGCGPANADRVLRRL----K 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 186 LLSDFDEfssrfknlahqhqsmfptleidiegqlkrlkgfaerIRPMVRDGVYFMYEALHGPpKKILVEGANAALLDIDF 265
Cdd:PRK04293 142 LAKDVEE------------------------------------LEKYLTDVPEEVNEALDRG-ENVLIEGTQGFGLSLYY 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 266 GTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGgllQTRG-HEWGVTTGRKRRCGWLD 344
Cdd:PRK04293 185 GTYPYVTSKDTTASGIASDVGVGPTKVDEVIVVFKSYPTRVGEGPFPTELSLEEA---EKLGlVEYGTVTGRRRRVGPFD 261

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 345 LMILRYAHMVNGFTALALTKLDILDvlgevkvgvsyklngkripyfpanqemlqkveveyetlpgwkADTTGARRWEDLP 424
Cdd:PRK04293 262 FELARRAARINGATQIAITKLDKLD------------------------------------------KEAYGVTEYDKLP 299

                        410       420       430
                 ....*....|....*....|....*....|...
gi 578825468 425 PQAQNYIRFVENHVGVAVKWVGVGKSRESMIQL 457
Cdd:PRK04293 300 PEAKKFIEEIEEELGVPVTLISTGPELEDTIDL 332
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
33-356 1.09e-26

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 109.00  E-value: 1.09e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  33 VTVVLGAQWGDEGKGKVVDLLATDADIISRCQ-GGNNAGHTVVVD-GKEYDFHLLPSGI-INTKAVSFIGNGVVIHLPGL 109
Cdd:NF038379   1 VDVVVDGQFGSTGKGLIAGYLAERAAPDVVVRaAGPNAGHTYIDDeGRKFVHRMLPNGIvSPPLKQVLIGPGSEIDLEVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 110 FEEAEKNEKKGLkDWEKRLIISDRAHLgdsgqqeaVDGLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTglricdllsd 189
Cdd:NF038379  81 REEIEELEDAGH-DVGKRLLIHEQATV--------IELHKHVEEEAGPMTKIGSTKKGIGAARAAKIRRN---------- 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 190 fdefssrfknlahqhqsmfPTLEIDIEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPPKKILVEGANAALLDIDFGTYP 269
Cdd:NF038379 142 -------------------PSTLGDAEGDFGEGAVRDQPWEIAERVVDNALYDFALQAAERIQIEGTQGYSLGLHAGFYP 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 270 FVTSSNCTVGGVCTGLGIPPQNI--GDVYGVVKAYTTRVGIGAFPT---------EQIneigGLLQtrghEWGVTTGRKR 338
Cdd:NF038379 203 YCTSRDCTPADFLADAGIPLPNVdaFKVVGTARTYPIRVAGWSGNSypdqgettwEEL----GLPE----ELTTVTKKVR 274

                        330
                 ....*....|....*...
gi 578825468 339 RCGWLDLMILRYAHMVNG 356
Cdd:NF038379 275 RVGTFSAEQVREAVQANG 292
PTZ00351 PTZ00351
adenylosuccinate synthetase; Provisional
 33-198 2.46e-10

adenylosuccinate synthetase; Provisional


Pssm-ID: 173544  Cd Length: 710  Bit Score: 62.76  E-value: 2.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468  33 VTVVLGAQWGDEGKGKVVDLLATD--ADIISRCQGGNNAGHTVVVD-GKEYDFHLLPSGIINTKAVSFIGNGVVIHlPGL 109
Cdd:PTZ00351 171 VIMVAGAFFGDEGKGKTVDAVAHHplCTCIARVNSGENAGHTVYDKaGRKFVFNLAPSGLLLPGKRNYIGPECVMD-PVS 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578825468 110 FEEAEKNE--KKGLkDWEKRLIISDRAHLgdSGQQEAVDGLQEVQRQaqegknigTTKKGIGPTYSSKAARTGLRICDLL 187
Cdd:PTZ00351 250 FMEKEIIQliDAGI-DYRDRLFIGNVCIV--TPYHKLLDLLGSAANS--------STLKGMAPVHGSKVMKRGIRLDHIF 318

                        170
                 ....*....|.
gi 578825468 188 SDFDEFSSRFK 198
Cdd:PTZ00351 319 NDDETLRKRLE 329
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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