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Conserved domains on  [gi|578824215|ref|XP_006719656|]
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N-acetylglucosamine-1-phosphotransferase subunits alpha/beta isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Stealth_CR2 pfam11380
Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved ...
 322-429 4.48e-64

Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


:

Pssm-ID: 463267  Cd Length: 108  Bit Score: 211.94  E-value: 4.48e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824215   322 RFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLNLDNPRVTIVTHQDVFRNLSHLPTFSSPAIESHIHRIEGLSQK 401
Cdd:pfam11380    1 RFRDRDELRYSLRSVEKYAPWVRKIYIVTDGQIPSWLNTSHPKIRIVDHKDIFPNESHLPTFNSHAIESNLHRIPGLSEH 80

                           90       100
                   ....*....|....*....|....*...
gi 578824215   402 FIYLNDDVMFGKDVWPDDFYSHSKGQKV 429
Cdd:pfam11380   81 FLYFNDDMFLGRPVKPEDFFTPDGLPKD 108
GlcNAc-1_reg pfam18440
Putative GlcNAc-1 phosphotransferase regulatory domain; The Golgi enzyme UDP-GlcNAc-lysosomal ...
 218-305 4.81e-48

Putative GlcNAc-1 phosphotransferase regulatory domain; The Golgi enzyme UDP-GlcNAc-lysosomal enzyme N-acetylglucosamine-1-phosphotransferase (GlcNAc-1-phosphotransferase), an alpha2beta2gamma2 hexamer, mediates the initial step in the addition of the mannose 6-phosphate targeting signal on newly synthesized lysosomal enzymes. GNPTAB encodes the alpha and beta subunits of GlcNAc-1-phosphotransferase, and mutations in this gene cause the lysosomal storage disorders mucolipidosis II and III alpha-beta The alpha-beta subunits contain three identifiable domains separated by so-called spacer regions. This domain is part of the first spacer region, Spacer-1. Studies indicate that GlcNAc-1 lacking spacer-1 exhibits enhanced phosphorylation of several non-lysosomal glycoproteins, while the phosphorylation of lysosomal acid hydrolases is not altered. In view of these effects on the maturation and function of GlcNAc-1, it is suggested to rename 'spacer-1' the 'regulatory-1' domain.


:

Pssm-ID: 408237  Cd Length: 88  Bit Score: 165.53  E-value: 4.81e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824215   218 VPGLVLMQDLAFLSGFPPTFKETNQLKTKLPENLSSKVKLLQLYSEASVALLKLNNPKDFQELNKQTKKNMTIDGKELTI 297
Cdd:pfam18440    1 VPGLVLMQDLAFLSGFPRTFKETNQLKTKLPEKLRSKVKLLQLYSEASVALLDLNNPKDFDELLKQGKKNMTIDGKELTL 80


                   ....*...
gi 578824215   298 SPAYLLWD 305
Cdd:pfam18440   81 TPAYLLWD 88
RRM1_GNPTAB cd21599
RNA recognition motif 1 (RRM1) found in N-acetylglucosamine-1-phosphotransferase subunits ...
 137-225 9.50e-38

RNA recognition motif 1 (RRM1) found in N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB) and similar proteins; GNPTAB, also termed GlcNAc-1-phosphotransferase subunits alpha/beta, or stealth protein GNPTAB, or UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta, catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. The model corresponds to the RNA recognition motif 1 (RRM1) of GNPTAB. Its functional significance remains to be investigated.


:

Pssm-ID: 410178 [Multi-domain]  Cd Length: 90  Bit Score: 136.27  E-value: 9.50e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824215  137 PMLVLDPALPANITLKDLPSLYPSFHSASDIFNVAKPKNPSTNVSVVVFDSTKDVEDAHSGLLK-GNSRQTVWRGYLTTD 215
Cdd:cd21599     1 PMLVLDPALPENITLEDLREIYPAFKSATKIFNVTKPTNPSTNVTVVVFSSQTEVDNALKEKLViNGKNHSVSRGYLTSD 80

                          90
                  ....*....|
gi 578824215  216 KEVPGLVLMQ 225
Cdd:cd21599    81 WTVPHSVLLK 90
DMAP_binding pfam06464
DMAP1-binding Domain; This domain binds DMAP1, a transcriptional co-repressor.
 699-814 1.46e-26

DMAP1-binding Domain; This domain binds DMAP1, a transcriptional co-repressor.


:

Pssm-ID: 368923 [Multi-domain]  Cd Length: 104  Bit Score: 104.81  E-value: 1.46e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824215   699 NISLLPKDAQLSLNTLDLQLEHGDITLKGYNLSKSALLRSFLMNSQHAkiknqaiitdeTNDSLVAPQEKQVHKSILPNS 778
Cdd:pfam06464    1 NPPSLPDDVRERLSELDLDLSEGDITEKGYEKKKLKLLRKFLLHPETP-----------TKLSAEAQNQLASLETKLRDE 69

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 578824215   779 lGVSERLQRLTFPAVSVKVNGHDQGQNPPLDLETTA 814
Cdd:pfam06464   70 -ELSEEVYLEKVKALLAKELERENGLNAPTKEQSGL 104
Stealth_CR3 pfam17102
Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved ...
 955-1003 1.41e-20

Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. The domain is found in tandem with CR1, CR2 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


:

Pssm-ID: 465347  Cd Length: 49  Bit Score: 86.04  E-value: 1.41e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578824215   955 AHMPHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMS 1003
Cdd:pfam17102    1 AHTPHPLRRSVLEEIEERFPEEFARTASHRFRSPDDLSMAFSYHHYYAE 49
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 436-469 3.39e-13

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 64.47  E-value: 3.39e-13
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 578824215   436 PNC-AEGCPgSWIKDGYCDKACNNSACDWDGGDCS 469
Cdd:pfam00066    2 PNCpYPYCW-DKFGNGVCDEECNNAECLWDGGDCS 35
Stealth_CR1 pfam17101
Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved ...
 73-101 3.77e-09

Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR1 carries a well-conserved IDVVYT sequence-motif. The domain is found in tandem with CR2, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


:

Pssm-ID: 465346  Cd Length: 29  Bit Score: 52.86  E-value: 3.77e-09
                           10        20
                   ....*....|....*....|....*....
gi 578824215    73 MPIDVVYTWVNGTDLELLKELQQVREQME 101
Cdd:pfam17101    1 FPIDVVYTWVNGSDPEWQAKKAKYLGKLG 29
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 503-535 4.04e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 47.14  E-value: 4.04e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 578824215   503 SYCN-QGCANSWlADKFCDQACNVLSCGFDAGDC 535
Cdd:pfam00066    2 PNCPyPYCWDKF-GNGVCDEECNNAECLWDGGDC 34
 
Name Accession Description Interval E-value
Stealth_CR2 pfam11380
Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved ...
 322-429 4.48e-64

Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 463267  Cd Length: 108  Bit Score: 211.94  E-value: 4.48e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824215   322 RFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLNLDNPRVTIVTHQDVFRNLSHLPTFSSPAIESHIHRIEGLSQK 401
Cdd:pfam11380    1 RFRDRDELRYSLRSVEKYAPWVRKIYIVTDGQIPSWLNTSHPKIRIVDHKDIFPNESHLPTFNSHAIESNLHRIPGLSEH 80

                           90       100
                   ....*....|....*....|....*...
gi 578824215   402 FIYLNDDVMFGKDVWPDDFYSHSKGQKV 429
Cdd:pfam11380   81 FLYFNDDMFLGRPVKPEDFFTPDGLPKD 108
GlcNAc-1_reg pfam18440
Putative GlcNAc-1 phosphotransferase regulatory domain; The Golgi enzyme UDP-GlcNAc-lysosomal ...
 218-305 4.81e-48

Putative GlcNAc-1 phosphotransferase regulatory domain; The Golgi enzyme UDP-GlcNAc-lysosomal enzyme N-acetylglucosamine-1-phosphotransferase (GlcNAc-1-phosphotransferase), an alpha2beta2gamma2 hexamer, mediates the initial step in the addition of the mannose 6-phosphate targeting signal on newly synthesized lysosomal enzymes. GNPTAB encodes the alpha and beta subunits of GlcNAc-1-phosphotransferase, and mutations in this gene cause the lysosomal storage disorders mucolipidosis II and III alpha-beta The alpha-beta subunits contain three identifiable domains separated by so-called spacer regions. This domain is part of the first spacer region, Spacer-1. Studies indicate that GlcNAc-1 lacking spacer-1 exhibits enhanced phosphorylation of several non-lysosomal glycoproteins, while the phosphorylation of lysosomal acid hydrolases is not altered. In view of these effects on the maturation and function of GlcNAc-1, it is suggested to rename 'spacer-1' the 'regulatory-1' domain.


Pssm-ID: 408237  Cd Length: 88  Bit Score: 165.53  E-value: 4.81e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824215   218 VPGLVLMQDLAFLSGFPPTFKETNQLKTKLPENLSSKVKLLQLYSEASVALLKLNNPKDFQELNKQTKKNMTIDGKELTI 297
Cdd:pfam18440    1 VPGLVLMQDLAFLSGFPRTFKETNQLKTKLPEKLRSKVKLLQLYSEASVALLDLNNPKDFDELLKQGKKNMTIDGKELTL 80


                   ....*...
gi 578824215   298 SPAYLLWD 305
Cdd:pfam18440   81 TPAYLLWD 88
RRM1_GNPTAB cd21599
RNA recognition motif 1 (RRM1) found in N-acetylglucosamine-1-phosphotransferase subunits ...
 137-225 9.50e-38

RNA recognition motif 1 (RRM1) found in N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB) and similar proteins; GNPTAB, also termed GlcNAc-1-phosphotransferase subunits alpha/beta, or stealth protein GNPTAB, or UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta, catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. The model corresponds to the RNA recognition motif 1 (RRM1) of GNPTAB. Its functional significance remains to be investigated.


Pssm-ID: 410178 [Multi-domain]  Cd Length: 90  Bit Score: 136.27  E-value: 9.50e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824215  137 PMLVLDPALPANITLKDLPSLYPSFHSASDIFNVAKPKNPSTNVSVVVFDSTKDVEDAHSGLLK-GNSRQTVWRGYLTTD 215
Cdd:cd21599     1 PMLVLDPALPENITLEDLREIYPAFKSATKIFNVTKPTNPSTNVTVVVFSSQTEVDNALKEKLViNGKNHSVSRGYLTSD 80

                          90
                  ....*....|
gi 578824215  216 KEVPGLVLMQ 225
Cdd:cd21599    81 WTVPHSVLLK 90
RRM2_GNPTAB cd21600
RNA recognition motif 2 (RRM2) found in N-acetylglucosamine-1-phosphotransferase subunits ...
 226-305 4.63e-29

RNA recognition motif 2 (RRM2) found in N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB) and similar proteins; GNPTAB, also termed GlcNAc-1-phosphotransferase subunits alpha/beta, or stealth protein GNPTAB, or UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta, catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. The model corresponds to the RNA recognition motif 2 (RRM2) of GNPTAB. Its functional significance remains to be investigated.


Pssm-ID: 410179  Cd Length: 77  Bit Score: 111.16  E-value: 4.63e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824215  226 DLAFLSGFPPTFkETNQLKTKLPENLSSKVKLLQLYSEASVALLKLNNPKDFQELNKQTkkNMTIDGKELTISPAYLLWD 305
Cdd:cd21600     1 DTIMMSGIPSTY-EEEQLLAKLPETIRSKISKVELYSEKGVAVLTLSDKKAFDELLKLS--NMTIDGKEITLSPAYLVWD 77
DMAP_binding pfam06464
DMAP1-binding Domain; This domain binds DMAP1, a transcriptional co-repressor.
 699-814 1.46e-26

DMAP1-binding Domain; This domain binds DMAP1, a transcriptional co-repressor.


Pssm-ID: 368923 [Multi-domain]  Cd Length: 104  Bit Score: 104.81  E-value: 1.46e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824215   699 NISLLPKDAQLSLNTLDLQLEHGDITLKGYNLSKSALLRSFLMNSQHAkiknqaiitdeTNDSLVAPQEKQVHKSILPNS 778
Cdd:pfam06464    1 NPPSLPDDVRERLSELDLDLSEGDITEKGYEKKKLKLLRKFLLHPETP-----------TKLSAEAQNQLASLETKLRDE 69

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 578824215   779 lGVSERLQRLTFPAVSVKVNGHDQGQNPPLDLETTA 814
Cdd:pfam06464   70 -ELSEEVYLEKVKALLAKELERENGLNAPTKEQSGL 104
Stealth_CR3 pfam17102
Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved ...
 955-1003 1.41e-20

Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. The domain is found in tandem with CR1, CR2 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 465347  Cd Length: 49  Bit Score: 86.04  E-value: 1.41e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578824215   955 AHMPHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMS 1003
Cdd:pfam17102    1 AHTPHPLRRSVLEEIEERFPEEFARTASHRFRSPDDLSMAFSYHHYYAE 49
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 436-469 3.39e-13

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 64.47  E-value: 3.39e-13
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 578824215   436 PNC-AEGCPgSWIKDGYCDKACNNSACDWDGGDCS 469
Cdd:pfam00066    2 PNCpYPYCW-DKFGNGVCDEECNNAECLWDGGDCS 35
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 434-468 1.01e-09

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 54.64  E-value: 1.01e-09
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 578824215    434 PVPNC-AEGCpgsW--IKDGYCDKACNNSACDWDGGDC 468
Cdd:smart00004    4 PWSRCeDAQC---WdkFGDGVCDEECNNAECLWDGGDC 38
Stealth_CR1 pfam17101
Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved ...
 73-101 3.77e-09

Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR1 carries a well-conserved IDVVYT sequence-motif. The domain is found in tandem with CR2, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 465346  Cd Length: 29  Bit Score: 52.86  E-value: 3.77e-09
                           10        20
                   ....*....|....*....|....*....
gi 578824215    73 MPIDVVYTWVNGTDLELLKELQQVREQME 101
Cdd:pfam17101    1 FPIDVVYTWVNGSDPEWQAKKAKYLGKLG 29
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 503-535 4.04e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 47.14  E-value: 4.04e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 578824215   503 SYCN-QGCANSWlADKFCDQACNVLSCGFDAGDC 535
Cdd:pfam00066    2 PNCPyPYCWDKF-GNGVCDEECNNAECLWDGGDC 34
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 515-535 2.08e-04

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 39.62  E-value: 2.08e-04
                            10        20
                    ....*....|....*....|.
gi 578824215    515 ADKFCDQACNVLSCGFDAGDC 535
Cdd:smart00004   18 GDGVCDEECNNAECLWDGGDC 38
 
Name Accession Description Interval E-value
Stealth_CR2 pfam11380
Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved ...
 322-429 4.48e-64

Stealth protein CR2, conserved region 2; Stealth_CR2 is the second of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR2 carries a well-conserved NDD sequence-motif. The domain is found in tandem with CR1, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 463267  Cd Length: 108  Bit Score: 211.94  E-value: 4.48e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824215   322 RFEDNEELRYSLRSIERHAPWVRNIFIVTNGQIPSWLNLDNPRVTIVTHQDVFRNLSHLPTFSSPAIESHIHRIEGLSQK 401
Cdd:pfam11380    1 RFRDRDELRYSLRSVEKYAPWVRKIYIVTDGQIPSWLNTSHPKIRIVDHKDIFPNESHLPTFNSHAIESNLHRIPGLSEH 80

                           90       100
                   ....*....|....*....|....*...
gi 578824215   402 FIYLNDDVMFGKDVWPDDFYSHSKGQKV 429
Cdd:pfam11380   81 FLYFNDDMFLGRPVKPEDFFTPDGLPKD 108
GlcNAc-1_reg pfam18440
Putative GlcNAc-1 phosphotransferase regulatory domain; The Golgi enzyme UDP-GlcNAc-lysosomal ...
 218-305 4.81e-48

Putative GlcNAc-1 phosphotransferase regulatory domain; The Golgi enzyme UDP-GlcNAc-lysosomal enzyme N-acetylglucosamine-1-phosphotransferase (GlcNAc-1-phosphotransferase), an alpha2beta2gamma2 hexamer, mediates the initial step in the addition of the mannose 6-phosphate targeting signal on newly synthesized lysosomal enzymes. GNPTAB encodes the alpha and beta subunits of GlcNAc-1-phosphotransferase, and mutations in this gene cause the lysosomal storage disorders mucolipidosis II and III alpha-beta The alpha-beta subunits contain three identifiable domains separated by so-called spacer regions. This domain is part of the first spacer region, Spacer-1. Studies indicate that GlcNAc-1 lacking spacer-1 exhibits enhanced phosphorylation of several non-lysosomal glycoproteins, while the phosphorylation of lysosomal acid hydrolases is not altered. In view of these effects on the maturation and function of GlcNAc-1, it is suggested to rename 'spacer-1' the 'regulatory-1' domain.


Pssm-ID: 408237  Cd Length: 88  Bit Score: 165.53  E-value: 4.81e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824215   218 VPGLVLMQDLAFLSGFPPTFKETNQLKTKLPENLSSKVKLLQLYSEASVALLKLNNPKDFQELNKQTKKNMTIDGKELTI 297
Cdd:pfam18440    1 VPGLVLMQDLAFLSGFPRTFKETNQLKTKLPEKLRSKVKLLQLYSEASVALLDLNNPKDFDELLKQGKKNMTIDGKELTL 80


                   ....*...
gi 578824215   298 SPAYLLWD 305
Cdd:pfam18440   81 TPAYLLWD 88
RRM1_GNPTAB cd21599
RNA recognition motif 1 (RRM1) found in N-acetylglucosamine-1-phosphotransferase subunits ...
 137-225 9.50e-38

RNA recognition motif 1 (RRM1) found in N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB) and similar proteins; GNPTAB, also termed GlcNAc-1-phosphotransferase subunits alpha/beta, or stealth protein GNPTAB, or UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta, catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. The model corresponds to the RNA recognition motif 1 (RRM1) of GNPTAB. Its functional significance remains to be investigated.


Pssm-ID: 410178 [Multi-domain]  Cd Length: 90  Bit Score: 136.27  E-value: 9.50e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824215  137 PMLVLDPALPANITLKDLPSLYPSFHSASDIFNVAKPKNPSTNVSVVVFDSTKDVEDAHSGLLK-GNSRQTVWRGYLTTD 215
Cdd:cd21599     1 PMLVLDPALPENITLEDLREIYPAFKSATKIFNVTKPTNPSTNVTVVVFSSQTEVDNALKEKLViNGKNHSVSRGYLTSD 80

                          90
                  ....*....|
gi 578824215  216 KEVPGLVLMQ 225
Cdd:cd21599    81 WTVPHSVLLK 90
RRM2_GNPTAB cd21600
RNA recognition motif 2 (RRM2) found in N-acetylglucosamine-1-phosphotransferase subunits ...
 226-305 4.63e-29

RNA recognition motif 2 (RRM2) found in N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB) and similar proteins; GNPTAB, also termed GlcNAc-1-phosphotransferase subunits alpha/beta, or stealth protein GNPTAB, or UDP-N-acetylglucosamine-1-phosphotransferase subunits alpha/beta, catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. The model corresponds to the RNA recognition motif 2 (RRM2) of GNPTAB. Its functional significance remains to be investigated.


Pssm-ID: 410179  Cd Length: 77  Bit Score: 111.16  E-value: 4.63e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824215  226 DLAFLSGFPPTFkETNQLKTKLPENLSSKVKLLQLYSEASVALLKLNNPKDFQELNKQTkkNMTIDGKELTISPAYLLWD 305
Cdd:cd21600     1 DTIMMSGIPSTY-EEEQLLAKLPETIRSKISKVELYSEKGVAVLTLSDKKAFDELLKLS--NMTIDGKEITLSPAYLVWD 77
DMAP_binding pfam06464
DMAP1-binding Domain; This domain binds DMAP1, a transcriptional co-repressor.
 699-814 1.46e-26

DMAP1-binding Domain; This domain binds DMAP1, a transcriptional co-repressor.


Pssm-ID: 368923 [Multi-domain]  Cd Length: 104  Bit Score: 104.81  E-value: 1.46e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578824215   699 NISLLPKDAQLSLNTLDLQLEHGDITLKGYNLSKSALLRSFLMNSQHAkiknqaiitdeTNDSLVAPQEKQVHKSILPNS 778
Cdd:pfam06464    1 NPPSLPDDVRERLSELDLDLSEGDITEKGYEKKKLKLLRKFLLHPETP-----------TKLSAEAQNQLASLETKLRDE 69

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 578824215   779 lGVSERLQRLTFPAVSVKVNGHDQGQNPPLDLETTA 814
Cdd:pfam06464   70 -ELSEEVYLEKVKALLAKELERENGLNAPTKEQSGL 104
Stealth_CR3 pfam17102
Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved ...
 955-1003 1.41e-20

Stealth protein CR3, conserved region 3; Stealth_CR3 is the third of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. The domain is found in tandem with CR1, CR2 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 465347  Cd Length: 49  Bit Score: 86.04  E-value: 1.41e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578824215   955 AHMPHMIDRIVMQELQDMFPEEFDKTSFHKVRHSEDMQFAFSYFYYLMS 1003
Cdd:pfam17102    1 AHTPHPLRRSVLEEIEERFPEEFARTASHRFRSPDDLSMAFSYHHYYAE 49
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 436-469 3.39e-13

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 64.47  E-value: 3.39e-13
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 578824215   436 PNC-AEGCPgSWIKDGYCDKACNNSACDWDGGDCS 469
Cdd:pfam00066    2 PNCpYPYCW-DKFGNGVCDEECNNAECLWDGGDCS 35
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 434-468 1.01e-09

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 54.64  E-value: 1.01e-09
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 578824215    434 PVPNC-AEGCpgsW--IKDGYCDKACNNSACDWDGGDC 468
Cdd:smart00004    4 PWSRCeDAQC---WdkFGDGVCDEECNNAECLWDGGDC 38
Stealth_CR1 pfam17101
Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved ...
 73-101 3.77e-09

Stealth protein CR1, conserved region 1; Stealth_C1 is the first of several highly conserved regions on stealth proteins in metazoa and bacteria. There are up to four CR regions on all member proteins. CR1 carries a well-conserved IDVVYT sequence-motif. The domain is found in tandem with CR2, CR3 and CR4 on both potential metazoan hosts and pathogenic eubacterial species that are capsular polysaccharide phosphotransferases. The CR domains appear on eukaryotic proteins such as GNPTAB, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta. Horizontal gene-transfer seems to have occurred between host and bacteria of these sequence-regions in order for the bacteria to evade detection by the host innate immune system.


Pssm-ID: 465346  Cd Length: 29  Bit Score: 52.86  E-value: 3.77e-09
                           10        20
                   ....*....|....*....|....*....
gi 578824215    73 MPIDVVYTWVNGTDLELLKELQQVREQME 101
Cdd:pfam17101    1 FPIDVVYTWVNGSDPEWQAKKAKYLGKLG 29
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 503-535 4.04e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 47.14  E-value: 4.04e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 578824215   503 SYCN-QGCANSWlADKFCDQACNVLSCGFDAGDC 535
Cdd:pfam00066    2 PNCPyPYCWDKF-GNGVCDEECNNAECLWDGGDC 34
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 515-535 2.08e-04

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 39.62  E-value: 2.08e-04
                            10        20
                    ....*....|....*....|.
gi 578824215    515 ADKFCDQACNVLSCGFDAGDC 535
Cdd:smart00004   18 GDGVCDEECNNAECLWDGGDC 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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