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Conserved domains on  [gi|578821371|ref|XP_006718596|]
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inner centromere protein isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
INCENP_N pfam12178
Chromosome passenger complex (CPC) protein INCENP N terminal; This domain family is found in ...
 6-41 8.98e-17

Chromosome passenger complex (CPC) protein INCENP N terminal; This domain family is found in eukaryotes, and is approximately 40 amino acids in length. INCENP is a regulatory protein in the chromosome passenger complex. It is involved in regulation of the catalytic protein Aurora B. It performs this function in association with two other proteins - Survivin and Borealin. These proteins form a tight three-helical bundle. The N terminal domain is the domain involved in formation of this three helical bundle.


:

Pssm-ID: 463484 [Multi-domain]  Cd Length: 36  Bit Score: 74.27  E-value: 8.98e-17
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578821371    6 PGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEA 41
Cdd:pfam12178   1 SGPASLLEVCDQKLSEFLCEIDNKHLVWLEEIEEEA 36
INCENP_ARK-bind pfam03941
Inner centromere protein, ARK binding region; This region of the inner centromere protein has ...
 831-885 2.72e-15

Inner centromere protein, ARK binding region; This region of the inner centromere protein has been found to be necessary and sufficient for binding to aurora-related kinase. This interaction has been implicated in the coordination of chromosome segregation with cell division in yeast.


:

Pssm-ID: 461100 [Multi-domain]  Cd Length: 53  Bit Score: 70.69  E-value: 2.72e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 578821371  831 NSDDSTDDEAHPRKPIPTWARGTPLSQAIIHQYyhPPNLLELFGTILPLDLEDIF 885
Cdd:pfam03941   1 NSDDEDDDEDEPRKPVPSWAQSPNLRQALIRQE--PIDPDEIFGPIPPLNLEEIF 53
PTZ00121 super family cl31754
MAEBL; Provisional
 536-794 4.43e-11

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 67.09  E-value: 4.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  536 EKERQRLENLRRKEEAEQLRRQKVEEDKR-----RRLEEVK----LKREERLRKVLQARERVEQMKEEKKKQIEQKFAQI 606
Cdd:PTZ00121 1506 AEAKKKADEAKKAEEAKKADEAKKAEEAKkadeaKKAEEKKkadeLKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEE 1585

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  607 DEKTEKAK--------EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQVRAQEEEERRhqellQKKKEEEQER 678
Cdd:PTZ00121 1586 AKKAEEARieevmklyEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAE-----ELKKAEEENK 1660

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  679 LRKAAEAKRlAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAErELQEREKALRLQKEQLQRE 758
Cdd:PTZ00121 1661 IKAAEEAKK-AEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAE-ELKKAEEENKIKAEEAKKE 1738

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 578821371  759 LEEKKKKEEQQRLAE------RQLQEEQEKKAKEAAGASKAL 794
Cdd:PTZ00121 1739 AEEDKKKAEEAKKDEeekkkiAHLKKEEEKKAEEIRKEKEAV 1780
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
141-287 1.76e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK08691:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 709  Bit Score: 42.00  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 141 PSSPTPESPTMLTK---KPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQ----GIPT 213
Cdd:PRK08691 380 PSAQTAEKETAAKKpqpRPEAETAQTPVQTASAAAMPSEGKTAGPVSNQENNDVPPWEDAPDEAQTAAGTAQtsakSIQT 459

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578821371 214 SDEESTPKK---SKARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPG-PRDSPAFPDSPWRERVLAPILP 287
Cdd:PRK08691 460 ASEAETPPEnqvSKNKAADNETDAPLSEVPSENPIQATPNDEAVETETFAHEAPAePFYGYGFPDNDCPPEDGAEIPP 537
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 142-513 5.21e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.67  E-value: 5.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  142 SSPTPE------SPTMLTKKPEDNHTqcqlvpvveigisERQNAEQHVTQLMSTEPLPRTLSPTPAsATAPTSQGIPTSD 215
Cdd:pfam05109 474 TSPTPAgttsgaSPVTPSPSPRDNGT-------------ESKAPDMTSPTSAVTTPTPNATSPTPA-VTTPTPNATSPTL 539

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  216 EESTPKKSKARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPrDSPAFPDSPWRERVLAPILPDNFSTPTG 295
Cdd:pfam05109 540 GKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNA-TSPTVGETSPQANTTNHTLGGTSSTPVV 618

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  296 SrtdsQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVrraSRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQ 375
Cdd:pfam05109 619 T----SPPKNATSAVTTGQHNITSSSTSSMSLRPSSI---SETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTST 691

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  376 KEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQ 455
Cdd:pfam05109 692 HHVSTSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPKNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHG 771

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578821371  456 AVSELDEEQHLEDEElQPPRSK---TPSSPCPASKVVRPLRTFLH---TVQRNQMLMTPTSAPR 513
Cdd:pfam05109 772 ARTSTEPTTDYGGDS-TTPRTRynaTTYLPPSTSSKLRPRWTFTSppvTTAQATVPVPPTSQPR 834
 
Name Accession Description Interval E-value
INCENP_N pfam12178
Chromosome passenger complex (CPC) protein INCENP N terminal; This domain family is found in ...
 6-41 8.98e-17

Chromosome passenger complex (CPC) protein INCENP N terminal; This domain family is found in eukaryotes, and is approximately 40 amino acids in length. INCENP is a regulatory protein in the chromosome passenger complex. It is involved in regulation of the catalytic protein Aurora B. It performs this function in association with two other proteins - Survivin and Borealin. These proteins form a tight three-helical bundle. The N terminal domain is the domain involved in formation of this three helical bundle.


Pssm-ID: 463484 [Multi-domain]  Cd Length: 36  Bit Score: 74.27  E-value: 8.98e-17
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578821371    6 PGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEA 41
Cdd:pfam12178   1 SGPASLLEVCDQKLSEFLCEIDNKHLVWLEEIEEEA 36
INCENP_ARK-bind pfam03941
Inner centromere protein, ARK binding region; This region of the inner centromere protein has ...
 831-885 2.72e-15

Inner centromere protein, ARK binding region; This region of the inner centromere protein has been found to be necessary and sufficient for binding to aurora-related kinase. This interaction has been implicated in the coordination of chromosome segregation with cell division in yeast.


Pssm-ID: 461100 [Multi-domain]  Cd Length: 53  Bit Score: 70.69  E-value: 2.72e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 578821371  831 NSDDSTDDEAHPRKPIPTWARGTPLSQAIIHQYyhPPNLLELFGTILPLDLEDIF 885
Cdd:pfam03941   1 NSDDEDDDEDEPRKPVPSWAQSPNLRQALIRQE--PIDPDEIFGPIPPLNLEEIF 53
PTZ00121 PTZ00121
MAEBL; Provisional
 536-794 4.43e-11

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 67.09  E-value: 4.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  536 EKERQRLENLRRKEEAEQLRRQKVEEDKR-----RRLEEVK----LKREERLRKVLQARERVEQMKEEKKKQIEQKFAQI 606
Cdd:PTZ00121 1506 AEAKKKADEAKKAEEAKKADEAKKAEEAKkadeaKKAEEKKkadeLKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEE 1585

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  607 DEKTEKAK--------EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQVRAQEEEERRhqellQKKKEEEQER 678
Cdd:PTZ00121 1586 AKKAEEARieevmklyEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAE-----ELKKAEEENK 1660

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  679 LRKAAEAKRlAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAErELQEREKALRLQKEQLQRE 758
Cdd:PTZ00121 1661 IKAAEEAKK-AEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAE-ELKKAEEENKIKAEEAKKE 1738

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 578821371  759 LEEKKKKEEQQRLAE------RQLQEEQEKKAKEAAGASKAL 794
Cdd:PTZ00121 1739 AEEDKKKAEEAKKDEeekkkiAHLKKEEEKKAEEIRKEKEAV 1780
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 536-794 1.92e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 64.96  E-value: 1.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 536 EKERQrLENLRRkeEAEQLRR-QKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAK 614
Cdd:COG1196  197 ELERQ-LEPLER--QAEKAERyRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 615 EERLAEEKAKKKAAAKKMEEVEA--------RRKQEEEARRLRWLQQVRAQEEEERRHQELLQKKKEEEQERLRKAAEAK 686
Cdd:COG1196  274 LELEELELELEEAQAEEYELLAElarleqdiARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEEL 353

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 687 RLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKE 766
Cdd:COG1196  354 EEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAEL 433

                        250       260
                 ....*....|....*....|....*...
gi 578821371 767 EQQRLAERQLQEEQEKKAKEAAGASKAL 794
Cdd:COG1196  434 EEEEEEEEEALEEAAEEEAELEEEEEAL 461
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 536-788 2.29e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 51.51  E-value: 2.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE 615
Cdd:pfam02463  206 AKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQE 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   616 ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQVRAQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQE 695
Cdd:pfam02463  286 EELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQ 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   696 RREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ 775
Cdd:pfam02463  366 EKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGK 445

                          250
                   ....*....|...
gi 578821371   776 LQEEQEKKAKEAA 788
Cdd:pfam02463  446 LTEEKEELEKQEL 458
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 527-788 5.91e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.89  E-value: 5.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   527 RMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK------EEKKKQIE 600
Cdd:TIGR02168  688 ELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSkeltelEAEIEELE 767

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   601 QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR--------WLQQVRAQEEEERRHQELLQKKK 672
Cdd:TIGR02168  768 ERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNeeaanlreRLESLERRIAATERRLEDLEEQI 847

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   673 EEEQERLRKAAEA-KRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKAL--- 748
Cdd:TIGR02168  848 EELSEDIESLAAEiEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLaql 927

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 578821371   749 RLQKEQLQRELeekkkKEEQQRLAERQLQEEQEKKAKEAA 788
Cdd:TIGR02168  928 ELRLEGLEVRI-----DNLQERLSEEYSLTLEEAEALENK 962
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 141-287 1.76e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 42.00  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 141 PSSPTPESPTMLTK---KPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQ----GIPT 213
Cdd:PRK08691 380 PSAQTAEKETAAKKpqpRPEAETAQTPVQTASAAAMPSEGKTAGPVSNQENNDVPPWEDAPDEAQTAAGTAQtsakSIQT 459

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578821371 214 SDEESTPKK---SKARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPG-PRDSPAFPDSPWRERVLAPILP 287
Cdd:PRK08691 460 ASEAETPPEnqvSKNKAADNETDAPLSEVPSENPIQATPNDEAVETETFAHEAPAePFYGYGFPDNDCPPEDGAEIPP 537
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 142-513 5.21e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.67  E-value: 5.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  142 SSPTPE------SPTMLTKKPEDNHTqcqlvpvveigisERQNAEQHVTQLMSTEPLPRTLSPTPAsATAPTSQGIPTSD 215
Cdd:pfam05109 474 TSPTPAgttsgaSPVTPSPSPRDNGT-------------ESKAPDMTSPTSAVTTPTPNATSPTPA-VTTPTPNATSPTL 539

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  216 EESTPKKSKARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPrDSPAFPDSPWRERVLAPILPDNFSTPTG 295
Cdd:pfam05109 540 GKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNA-TSPTVGETSPQANTTNHTLGGTSSTPVV 618

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  296 SrtdsQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVrraSRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQ 375
Cdd:pfam05109 619 T----SPPKNATSAVTTGQHNITSSSTSSMSLRPSSI---SETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTST 691

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  376 KEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQ 455
Cdd:pfam05109 692 HHVSTSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPKNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHG 771

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578821371  456 AVSELDEEQHLEDEElQPPRSK---TPSSPCPASKVVRPLRTFLH---TVQRNQMLMTPTSAPR 513
Cdd:pfam05109 772 ARTSTEPTTDYGGDS-TTPRTRynaTTYLPPSTSSKLRPRWTFTSppvTTAQATVPVPPTSQPR 834
 
Name Accession Description Interval E-value
INCENP_N pfam12178
Chromosome passenger complex (CPC) protein INCENP N terminal; This domain family is found in ...
 6-41 8.98e-17

Chromosome passenger complex (CPC) protein INCENP N terminal; This domain family is found in eukaryotes, and is approximately 40 amino acids in length. INCENP is a regulatory protein in the chromosome passenger complex. It is involved in regulation of the catalytic protein Aurora B. It performs this function in association with two other proteins - Survivin and Borealin. These proteins form a tight three-helical bundle. The N terminal domain is the domain involved in formation of this three helical bundle.


Pssm-ID: 463484 [Multi-domain]  Cd Length: 36  Bit Score: 74.27  E-value: 8.98e-17
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578821371    6 PGPIHLLELCDQKLMEFLCNMDNKDLVWLEEIQEEA 41
Cdd:pfam12178   1 SGPASLLEVCDQKLSEFLCEIDNKHLVWLEEIEEEA 36
INCENP_ARK-bind pfam03941
Inner centromere protein, ARK binding region; This region of the inner centromere protein has ...
 831-885 2.72e-15

Inner centromere protein, ARK binding region; This region of the inner centromere protein has been found to be necessary and sufficient for binding to aurora-related kinase. This interaction has been implicated in the coordination of chromosome segregation with cell division in yeast.


Pssm-ID: 461100 [Multi-domain]  Cd Length: 53  Bit Score: 70.69  E-value: 2.72e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 578821371  831 NSDDSTDDEAHPRKPIPTWARGTPLSQAIIHQYyhPPNLLELFGTILPLDLEDIF 885
Cdd:pfam03941   1 NSDDEDDDEDEPRKPVPSWAQSPNLRQALIRQE--PIDPDEIFGPIPPLNLEEIF 53
PTZ00121 PTZ00121
MAEBL; Provisional
 536-794 4.43e-11

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 67.09  E-value: 4.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  536 EKERQRLENLRRKEEAEQLRRQKVEEDKR-----RRLEEVK----LKREERLRKVLQARERVEQMKEEKKKQIEQKFAQI 606
Cdd:PTZ00121 1506 AEAKKKADEAKKAEEAKKADEAKKAEEAKkadeaKKAEEKKkadeLKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEE 1585

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  607 DEKTEKAK--------EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQVRAQEEEERRhqellQKKKEEEQER 678
Cdd:PTZ00121 1586 AKKAEEARieevmklyEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAE-----ELKKAEEENK 1660

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  679 LRKAAEAKRlAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAErELQEREKALRLQKEQLQRE 758
Cdd:PTZ00121 1661 IKAAEEAKK-AEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAE-ELKKAEEENKIKAEEAKKE 1738

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 578821371  759 LEEKKKKEEQQRLAE------RQLQEEQEKKAKEAAGASKAL 794
Cdd:PTZ00121 1739 AEEDKKKAEEAKKDEeekkkiAHLKKEEEKKAEEIRKEKEAV 1780
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 536-794 1.92e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 64.96  E-value: 1.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 536 EKERQrLENLRRkeEAEQLRR-QKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAK 614
Cdd:COG1196  197 ELERQ-LEPLER--QAEKAERyRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 615 EERLAEEKAKKKAAAKKMEEVEA--------RRKQEEEARRLRWLQQVRAQEEEERRHQELLQKKKEEEQERLRKAAEAK 686
Cdd:COG1196  274 LELEELELELEEAQAEEYELLAElarleqdiARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEEL 353

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 687 RLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKE 766
Cdd:COG1196  354 EEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAEL 433

                        250       260
                 ....*....|....*....|....*...
gi 578821371 767 EQQRLAERQLQEEQEKKAKEAAGASKAL 794
Cdd:COG1196  434 EEEEEEEEEALEEAAEEEAELEEEEEAL 461
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 535-791 2.39e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 64.57  E-value: 2.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKfaQIDEKTEKAK 614
Cdd:COG1196  244 LEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERR--RELEERLEEL 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 615 EERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQVRAQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQ 694
Cdd:COG1196  322 EEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQ 401

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 695 ERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAER 774
Cdd:COG1196  402 LEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAE 481

                        250
                 ....*....|....*..
gi 578821371 775 QLQEEQEKKAKEAAGAS 791
Cdd:COG1196  482 LLEELAEAAARLLLLLE 498
PTZ00121 PTZ00121
MAEBL; Provisional
 537-785 5.12e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 63.62  E-value: 5.12e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  537 KERQRLENLRRK-EEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK--------EEKKKQIEQKFAQID 607
Cdd:PTZ00121 1454 EEAKKAEEAKKKaEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKkadeakkaEEAKKADEAKKAEEA 1533

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  608 EKTE---KAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARR---------LRWLQQVRAQEEEERRHQELLQK----K 671
Cdd:PTZ00121 1534 KKADeakKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKnmalrkaeeAKKAEEARIEEVMKLYEEEKKMKaeeaK 1613

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  672 KEEEQ----ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKA 747
Cdd:PTZ00121 1614 KAEEAkikaEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEA 1693

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 578821371  748 LRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 785
Cdd:PTZ00121 1694 LKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIK 1731
PTZ00121 PTZ00121
MAEBL; Provisional
 538-792 9.18e-10

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.85  E-value: 9.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  538 ERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREErLRKVLQARERVEQMK--EEKKKQIEQKFAQIDEKTEKAKE 615
Cdd:PTZ00121 1573 EEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEE-AKKAEEAKIKAEELKkaEEEKKKVEQLKKKEAEEKKKAEE 1651

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  616 ERlaeekakKKAAAKKMEEVEARRKQEEEARRLRwlqqvraqeeeerrhqellQKKKEEEQERlRKAAEAKRLAEQREQE 695
Cdd:PTZ00121 1652 LK-------KAEEENKIKAAEEAKKAEEDKKKAE-------------------EAKKAEEDEK-KAAEALKKEAEEAKKA 1704

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  696 RREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ 775
Cdd:PTZ00121 1705 EELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEE 1784

                         250
                  ....*....|....*..
gi 578821371  776 LQEEQEKKAKEAAGASK 792
Cdd:PTZ00121 1785 LDEEDEKRRMEVDKKIK 1801
PTZ00121 PTZ00121
MAEBL; Provisional
 537-792 1.56e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.08  E-value: 1.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  537 KERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK---------EEKKKQIEQKFAQID 607
Cdd:PTZ00121 1287 EEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKkaaeaakaeAEAAADEAEAAEEKA 1366

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  608 EKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQVRAQEEEERRHqellqKKKEEEQerlRKAAEAKR 687
Cdd:PTZ00121 1367 EAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEA-----KKKAEEK---KKADEAKK 1438

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  688 LAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQE-REKALRLQKEQLQRELEEKKKKE 766
Cdd:PTZ00121 1439 KAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEaKKKADEAKKAAEAKKKADEAKKA 1518

                         250       260
                  ....*....|....*....|....*.
gi 578821371  767 EQQRLAERQLQEEQEKKAKEAAGASK 792
Cdd:PTZ00121 1519 EEAKKADEAKKAEEAKKADEAKKAEE 1544
PTZ00121 PTZ00121
MAEBL; Provisional
 534-687 1.89e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 62.08  E-value: 1.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  534 FVEKERQRLENLRRKEE----AEQLRRqkvEEDKRRRLEEVKLKREERLRKVLQARERVEQMK----EEKKKQIEQKfaQ 605
Cdd:PTZ00121 1601 YEEEKKMKAEEAKKAEEakikAEELKK---AEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKikaaEEAKKAEEDK--K 1675

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  606 IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLrwlQQVRAQEEEERRHQELLQKKKEEEQerlRKAAEA 685
Cdd:PTZ00121 1676 KAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKA---EELKKAEEENKIKAEEAKKEAEEDK---KKAEEA 1749


                  ..
gi 578821371  686 KR 687
Cdd:PTZ00121 1750 KK 1751
PTZ00121 PTZ00121
MAEBL; Provisional
 536-793 9.25e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 59.77  E-value: 9.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  536 EKERQRLENLRRKEEAEQLRRQ-KVEEDKRRRLEEVKLKREERlRKVLQARERVEQMK--EEKKKQIEQKfAQIDEKTEK 612
Cdd:PTZ00121 1401 EEDKKKADELKKAAAAKKKADEaKKKAEEKKKADEAKKKAEEA-KKADEAKKKAEEAKkaEEAKKKAEEA-KKADEAKKK 1478

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  613 AKEERlAEEKAKKKAAAKKMEEVEARRKQE-----------EEARRLRWLQQVRAQEEEERRHQELLQKKKEE--EQERL 679
Cdd:PTZ00121 1479 AEEAK-KADEAKKKAEEAKKKADEAKKAAEakkkadeakkaEEAKKADEAKKAEEAKKADEAKKAEEKKKADElkKAEEL 1557

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  680 RKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQerlQAERELQEREKALRLQKEQLQREL 759
Cdd:PTZ00121 1558 KKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAE---EAKKAEEAKIKAEELKKAEEEKKK 1634

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 578821371  760 EEKKKKEEQQ--RLAERQLQEEQEKKAKEAAGASKA 793
Cdd:PTZ00121 1635 VEQLKKKEAEekKKAEELKKAEEENKIKAAEEAKKA 1670
PTZ00121 PTZ00121
MAEBL; Provisional
 521-687 8.35e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 56.69  E-value: 8.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  521 KRNTPLRMDPKCSFVEKER----QRLENLRRKEEAEQLRRqkvEEDKRRRLEEVKlKREERLRKVLQARERVEQMK---E 593
Cdd:PTZ00121 1575 DKNMALRKAEEAKKAEEARieevMKLYEEEKKMKAEEAKK---AEEAKIKAEELK-KAEEEKKKVEQLKKKEAEEKkkaE 1650

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  594 EKKKQIEQKFAQIDEKTEKAKEERlAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQVRAQEEEERrhqellQKKKE 673
Cdd:PTZ00121 1651 ELKKAEEENKIKAAEEAKKAEEDK-KKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKA------EELKK 1723

                         170
                  ....*....|....
gi 578821371  674 EEQERLRKAAEAKR 687
Cdd:PTZ00121 1724 AEEENKIKAEEAKK 1737
PTZ00121 PTZ00121
MAEBL; Provisional
 537-793 1.55e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.53  E-value: 1.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  537 KERQRLENLRRKEEAEQLRRQKVEEDKR-----RRLEEVK----LKREERLRKVLQAR--------ERVEQMKEEKKKQI 599
Cdd:PTZ00121 1149 EDAKRVEIARKAEDARKAEEARKAEDAKkaeaaRKAEEVRkaeeLRKAEDARKAEAARkaeeerkaEEARKAEDAKKAEA 1228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  600 EQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQVRAQEeeerrhqellQKKKEEE---Q 676
Cdd:PTZ00121 1229 VKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAE----------EKKKADEakkA 1298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  677 ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERElQEREKALRLQKEQLQ 756
Cdd:PTZ00121 1299 EEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAA-EEKAEAAEKKKEEAK 1377

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 578821371  757 RELEEKKKKEEQQRLAE--RQLQEEQEKKAKEAAGASKA 793
Cdd:PTZ00121 1378 KKADAAKKKAEEKKKADeaKKKAEEDKKKADELKKAAAA 1416
PTZ00121 PTZ00121
MAEBL; Provisional
 536-786 4.98e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.99  E-value: 4.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  536 EKERQRLENLRRKEE----AEQLRRqKVEEDKRRRlEEVKlKREERLRKVLQARERVEQMK--EEKKKQIEQKfAQIDEK 609
Cdd:PTZ00121 1374 EEAKKKADAAKKKAEekkkADEAKK-KAEEDKKKA-DELK-KAAAAKKKADEAKKKAEEKKkaDEAKKKAEEA-KKADEA 1449

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  610 TEKAKEERlaeEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQV--RAQEEEERRHQELLQKKKEEE---QERLRKAAE 684
Cdd:PTZ00121 1450 KKKAEEAK---KAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKaeEAKKKADEAKKAAEAKKKADEakkAEEAKKADE 1526

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  685 AKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKK 764
Cdd:PTZ00121 1527 AKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKK 1606

                         250       260
                  ....*....|....*....|....
gi 578821371  765 KEEQQ--RLAERQLQEEQEKKAKE 786
Cdd:PTZ00121 1607 MKAEEakKAEEAKIKAEELKKAEE 1630
PTZ00121 PTZ00121
MAEBL; Provisional
 537-793 5.51e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.99  E-value: 5.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  537 KERQRLENLRRKEEA---EQLRR----QKVEEDKR-----RRLEEVKLKRE----ERLRKVLQARERVEQMKEEKKKQIE 600
Cdd:PTZ00121 1203 EAARKAEEERKAEEArkaEDAKKaeavKKAEEAKKdaeeaKKAEEERNNEEirkfEEARMAHFARRQAAIKAEEARKADE 1282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  601 QKFAQIDEKTEKAKE-ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQVRAQEEEERRHQELLQKKKEEEQERL 679
Cdd:PTZ00121 1283 LKKAEEKKKADEAKKaEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAA 1362

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  680 RKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAErELQEREKALRLQKEQLQREL 759
Cdd:PTZ00121 1363 EEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKAD-EAKKKAEEKKKADEAKKKAE 1441

                         250       260       270
                  ....*....|....*....|....*....|....
gi 578821371  760 EEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKA 793
Cdd:PTZ00121 1442 EAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEA 1475
PTZ00121 PTZ00121
MAEBL; Provisional
 537-787 5.75e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.61  E-value: 5.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  537 KERQRLENLRRKEEAEQLRRQKVEEDKR-----RRLEEVklKREERLRKVLQARERVEQMKEEKKKQIEQkfAQIDEKTE 611
Cdd:PTZ00121 1137 EDARKAEEARKAEDAKRVEIARKAEDARkaeeaRKAEDA--KKAEAARKAEEVRKAEELRKAEDARKAEA--ARKAEEER 1212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  612 KAKEERlaeeKAKKKAAAKKMEEVEARRKQEEEARR---LRWLQQVRAQEEEERRHQELLQKKKEEEQErlRKAAEAKRl 688
Cdd:PTZ00121 1213 KAEEAR----KAEDAKKAEAVKKAEEAKKDAEEAKKaeeERNNEEIRKFEEARMAHFARRQAAIKAEEA--RKADELKK- 1285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  689 AEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 768
Cdd:PTZ00121 1286 AEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEK 1365

                         250
                  ....*....|....*....
gi 578821371  769 QRLAERQlQEEQEKKAKEA 787
Cdd:PTZ00121 1366 AEAAEKK-KEEAKKKADAA 1383
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 536-788 2.29e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 51.51  E-value: 2.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE 615
Cdd:pfam02463  206 AKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQE 285

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   616 ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQVRAQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQE 695
Cdd:pfam02463  286 EELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQ 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   696 RREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ 775
Cdd:pfam02463  366 EKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGK 445

                          250
                   ....*....|...
gi 578821371   776 LQEEQEKKAKEAA 788
Cdd:pfam02463  446 LTEEKEELEKQEL 458
PTZ00121 PTZ00121
MAEBL; Provisional
 521-794 2.36e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 51.68  E-value: 2.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  521 KRNTPLRMDPKCSFVEKERQR---LENLRRKEEAEQLRRQKVEEDkrRRLEEVKlKREERLRKVLQARERVEQMK-EEKK 596
Cdd:PTZ00121 1070 EGLKPSYKDFDFDAKEDNRADeatEEAFGKAEEAKKTETGKAEEA--RKAEEAK-KKAEDARKAEEARKAEDARKaEEAR 1146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  597 KQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEeearrLRWLQQVRAQEEEerrhqellqKKKEEEQ 676
Cdd:PTZ00121 1147 KAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAEEVRKAEE-----LRKAEDARKAEAA---------RKAEEER 1212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  677 --ERLRKAAEAKRL-AEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQK- 752
Cdd:PTZ00121 1213 kaEEARKAEDAKKAeAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKa 1292

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 578821371  753 EQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKAL 794
Cdd:PTZ00121 1293 DEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAA 1334
PRK12704 PRK12704
phosphodiesterase; Provisional
 533-615 7.05e-06

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 49.78  E-value: 7.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 533 SFVEKERQRLENLRR------KEEAEQLRRQkVEEDKRRRLEEVK------LKREERLRKVLQARERVEQMKEEKKKQIE 600
Cdd:PRK12704  42 RILEEAKKEAEAIKKealleaKEEIHKLRNE-FEKELRERRNELQklekrlLQKEENLDRKLELLEKREEELEKKEKELE 120

                         90
                 ....*....|....*
gi 578821371 601 QKFAQIDEKTEKAKE 615
Cdd:PRK12704 121 QKQQELEKKEEELEE 135
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 536-786 9.98e-06

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 49.35  E-value: 9.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  536 EKERQRLENLRRKEEAEQLRRQK--VEEDKRRRLEEVKLKRE---ERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKT 610
Cdd:pfam17380 347 ERELERIRQEERKRELERIRQEEiaMEISRMRELERLQMERQqknERVRQELEAARKVKILEEERQRKIQQQKVEMEQIR 426

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  611 EKAKEERlaeekakkkaaakkmeEVEARRKQEEEARRLrwlQQVRAQEEEERRHQELLqkkKEEEQERLRKAAEAKRLAE 690
Cdd:pfam17380 427 AEQEEAR----------------QREVRRLEEERAREM---ERVRLEEQERQQQVERL---RQQEEERKRKKLELEKEKR 484

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  691 QREQERREQERREQERREQERREQERREQERQLAeqerrreqerlqaERELQEREKALRLQKEQLQREleekKKKEEQQR 770
Cdd:pfam17380 485 DRKRAEEQRRKILEKELEERKQAMIEEERKRKLL-------------EKEMEERQKAIYEEERRREAE----EERRKQQE 547

                         250
                  ....*....|....*.
gi 578821371  771 LAERQLQEEQEKKAKE 786
Cdd:pfam17380 548 MEERRRIQEQMRKATE 563
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 536-795 1.67e-05

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 48.81  E-value: 1.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   536 EKERQRLENLRRKEE--AEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKA 613
Cdd:pfam02463  169 RKKKEALKKLIEETEnlAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRD 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   614 KEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLrwlqqvraqeeeERRHQELLQKKKEEEQERLRKAAEAKRLAEQRE 693
Cdd:pfam02463  249 EQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKL------------QEEELKLLAKEEEELKSELLKLERRKVDDEEKL 316

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   694 QERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAE 773
Cdd:pfam02463  317 KESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEE 396

                          250       260
                   ....*....|....*....|..
gi 578821371   774 RQLQEEQEKKAKEAAGASKALN 795
Cdd:pfam02463  397 LELKSEEEKEAQLLLELARQLE 418
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 537-689 2.12e-05

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 47.88  E-value: 2.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 537 KERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLrkvlQARERVEQMKEEKKKQIEQKFAQIDektekAKEE 616
Cdd:PRK09510  84 KEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAK----QAALKQKQAEEAAAKAAAAAKAKAE-----AEAK 154

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578821371 617 RLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQVRAQEEEERRHQELLQKKKEEEQERLRKAAEAKRLA 689
Cdd:PRK09510 155 RAAAAAKKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAAEAKAAA 227
PTZ00121 PTZ00121
MAEBL; Provisional
 536-793 2.28e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.60  E-value: 2.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  536 EKERQRLENLRRKEEAEQLRRqkveEDKRRRLEEVKLKREERlRKVLQARERVEQMK----EEKKKQIEQKFAqiDEKTE 611
Cdd:PTZ00121 1353 EAAADEAEAAEEKAEAAEKKK----EEAKKKADAAKKKAEEK-KKADEAKKKAEEDKkkadELKKAAAAKKKA--DEAKK 1425

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  612 KAKEERlaeEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQvraqEEEERRHQELLQKKKEEEqerlRKAAEAKRLAEQ 691
Cdd:PTZ00121 1426 KAEEKK---KADEAKKKAEEAKKADEAKKKAEEAKKAEEAKK----KAEEAKKADEAKKKAEEA----KKADEAKKKAEE 1494

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  692 REQERREQERREQERREQERREQERREQERQLAEQERRREQErlQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRL 771
Cdd:PTZ00121 1495 AKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKA--DEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKA 1572

                         250       260
                  ....*....|....*....|..
gi 578821371  772 AERqlQEEQEKKAKEAAGASKA 793
Cdd:PTZ00121 1573 EED--KNMALRKAEEAKKAEEA 1592
PTZ00121 PTZ00121
MAEBL; Provisional
 536-793 2.60e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.21  E-value: 2.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  536 EKERQRLENLRRKEEAeqlrRQKVEEdkRRRLEEVklKREERLRKVLQARERVEQMKEEKKKQIEQ-KFAQIDEKTEKAK 614
Cdd:PTZ00121 1105 KTETGKAEEARKAEEA----KKKAED--ARKAEEA--RKAEDARKAEEARKAEDAKRVEIARKAEDaRKAEEARKAEDAK 1176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  615 EERLAEEKAKKKAAAKKMEEVEARRKqeEEARR---LRWLQQVRaqeeeerrhqellQKKKEEEQERLRKAAEAKRLAEQ 691
Cdd:PTZ00121 1177 KAEAARKAEEVRKAEELRKAEDARKA--EAARKaeeERKAEEAR-------------KAEDAKKAEAVKKAEEAKKDAEE 1241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  692 REQERREQERREQERREQERREQERREQERQLAEQERRREQErlqaeRELQEREKALRLQKEQLQRELEEKKKKEEQQRL 771
Cdd:PTZ00121 1242 AKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADEL-----KKAEEKKKADEAKKAEEKKKADEAKKKAEEAKK 1316

                         250       260
                  ....*....|....*....|..
gi 578821371  772 AERQLQEEQEKKAKEAAGASKA 793
Cdd:PTZ00121 1317 ADEAKKKAEEAKKKADAAKKKA 1338
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
 529-688 3.65e-05

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 464815 [Multi-domain]  Cd Length: 522  Bit Score: 47.25  E-value: 3.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  529 DPKCSFVEKERQRLENLRR-KEEAEQLRRQKVEEDKRRRLEEVKLKREERlrkvlqarERVEQMKEEKKKQIEQKFAQID 607
Cdd:pfam15709 319 DPSKALLEKREQEKASRDRlRAERAEMRRLEVERKRREQEEQRRLQQEQL--------ERAEKMREELELEQQRRFEEIR 390

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  608 EKTEKAKEERLAEEKAKKKAAAKKMEEVE-ARRKQEEEARRLRWLQQVRAQEEEERRHQELLQKKKEE-----EQERLRK 681
Cdd:pfam15709 391 LRKQRLEEERQRQEEEERKQRLQLQAAQErARQQQEEFRRKLQELQRKKQQEEAERAEAEKQRQKELEmqlaeEQKRLME 470


                  ....*..
gi 578821371  682 AAEAKRL 688
Cdd:pfam15709 471 MAEEERL 477
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 546-794 6.00e-05

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 46.89  E-value: 6.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   546 RRKEEAEQLRRQKVEEDKRRRLEEvklKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKK 625
Cdd:pfam02463  154 RRLEIEEEAAGSRLKRKKKEALKK---LIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLD 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   626 KAAAKKMEEVEARRKQEEEARRLRWLQQVRAQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQE 705
Cdd:pfam02463  231 YLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKV 310

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   706 RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 785
Cdd:pfam02463  311 DDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAA 390


                   ....*....
gi 578821371   786 EAAGASKAL 794
Cdd:pfam02463  391 KLKEEELEL 399
PTZ00121 PTZ00121
MAEBL; Provisional
 535-792 9.82e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 9.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKL---KREERLRKVLQARERVEQMKEEKKKQIEQkfAQIDEKTE 611
Cdd:PTZ00121 1111 AEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAedaKRVEIARKAEDARKAEEARKAEDAKKAEA--ARKAEEVR 1188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  612 KAKEERLAE--EKAKKKAAAKKMEEVEARRKQEEEAR--RLRWLQQVRAQEEEERRHQELLQKKKEEEQERLRKAAEAKR 687
Cdd:PTZ00121 1189 KAEELRKAEdaRKAEAARKAEEERKAEEARKAEDAKKaeAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARR 1268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  688 LAEQREQERREQERREQERREQERREQERREQERQLAeqerrreqerlQAERELQEREKALRLQK--EQLQRELEEKKKK 765
Cdd:PTZ00121 1269 QAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKAD-----------EAKKKAEEAKKADEAKKkaEEAKKKADAAKKK 1337

                         250       260
                  ....*....|....*....|....*..
gi 578821371  766 EEQQRLAERQLQEEQEKKAKEAAGASK 792
Cdd:PTZ00121 1338 AEEAKKAAEAAKAEAEAAADEAEAAEE 1364
PTZ00121 PTZ00121
MAEBL; Provisional
 536-793 1.16e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  536 EKERQRlENLRRKEEAEQL----RRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAqiDEKTE 611
Cdd:PTZ00121 1246 EEERNN-EEIRKFEEARMAhfarRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKA--DEAKK 1322

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  612 KAKEERlaeekakKKAAAKKMEEVEARRKQE----EEARRLRWLQQVRAQEEEERRHQELLQKKKEE---EQERLRKAAE 684
Cdd:PTZ00121 1323 KAEEAK-------KKADAAKKKAEEAKKAAEaakaEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAakkKAEEKKKADE 1395

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  685 AKRLAEQREQERRE-QERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKE-QLQRELEEK 762
Cdd:PTZ00121 1396 AKKKAEEDKKKADElKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKaEEAKKADEA 1475

                         250       260       270
                  ....*....|....*....|....*....|...
gi 578821371  763 KKKEEQQRLAE--RQLQEEQEKKAKEAAGASKA 793
Cdd:PTZ00121 1476 KKKAEEAKKADeaKKKAEEAKKKADEAKKAAEA 1508
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 546-689 1.37e-04

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 45.18  E-value: 1.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 546 RRKEEaeqlRRQKVEEDKRRRLEEVKLKREERLRKVLQARErveQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKK 625
Cdd:PRK09510  75 KRAEE----QRKKKEQQQAEELQQKQAAEQERLKQLEKERL---AAQEQKKQAEEAAKQAALKQKQAEEAAAKAAAAAKA 147

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578821371 626 KAAAKKMEEVEARRKQEEEARRLRWLQQVRAQEEEERRHQELLQKKKEEEQERLRKAAEAKRLA 689
Cdd:PRK09510 148 KAEAEAKRAAAAAKKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKA 211
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 536-802 2.06e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.31  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE 615
Cdd:COG1196  374 LAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAE 453

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 616 ERLaeekakkkaaakkmEEVEARRKQEEEARRLRWLQQVRAQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQE 695
Cdd:COG1196  454 LEE--------------EEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGL 519

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 696 RREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQ 775
Cdd:COG1196  520 RGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGA 599

                        250       260
                 ....*....|....*....|....*..
gi 578821371 776 LQEEQEKKAKEAAGASKALNVTVDVQS 802
Cdd:COG1196  600 AVDLVASDLREADARYYVLGDTLLGRT 626
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 547-793 3.53e-04

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 44.55  E-value: 3.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 547 RKEEAEQLRRQKVE-EDKRRRLEEVKLKREERLRK------------VLQARERVEQMKEEKKKQIEQKFAQIDEKTEKA 613
Cdd:PRK05035 441 IEQEKKKAEEAKARfEARQARLEREKAAREARHKKaaearaakdkdaVAAALARVKAKKAAATQPIVIKAGARPDNSAVI 520

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 614 KEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQVRAQEEEERrhqellqkkKEEEQERLRKAAEAKRLAEQRE 693
Cdd:PRK05035 521 AAREARKAQARARQAEKQAAAAADPKKAAVAAAIARAKAKKAAQQAANA---------EAEEEVDPKKAAVAAAIARAKA 591

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 694 QERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKalrlqKEQLQRELEEKK-KKEEQQRLA 772
Cdd:PRK05035 592 KKAAQQAASAEPEEQVAEVDPKKAAVAAAIARAKAKKAEQQANAEPEEPVDPR-----KAAVAAAIARAKaRKAAQQQAN 666

                        250       260
                 ....*....|....*....|.
gi 578821371 773 ERQLQEEQEKKAKEAAGASKA 793
Cdd:PRK05035 667 AEPEEAEDPKKAAVAAAIARA 687
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 527-788 5.91e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.89  E-value: 5.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   527 RMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMK------EEKKKQIE 600
Cdd:TIGR02168  688 ELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSkeltelEAEIEELE 767

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   601 QKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR--------WLQQVRAQEEEERRHQELLQKKK 672
Cdd:TIGR02168  768 ERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNeeaanlreRLESLERRIAATERRLEDLEEQI 847

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   673 EEEQERLRKAAEA-KRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQEREKAL--- 748
Cdd:TIGR02168  848 EELSEDIESLAAEiEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLaql 927

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 578821371   749 RLQKEQLQRELeekkkKEEQQRLAERQLQEEQEKKAKEAA 788
Cdd:TIGR02168  928 ELRLEGLEVRI-----DNLQERLSEEYSLTLEEAEALENK 962
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 535-689 5.96e-04

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 43.30  E-value: 5.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  535 VEKERQRLENLRRKEEAEQ--LRRQKVEEDKRRRLEEVKLKR-EERLRKVLQARErveqmKEEKKKQIEQKFAQIDEKTE 611
Cdd:TIGR02794  52 ANRIQQQKKPAAKKEQERQkkLEQQAEEAEKQRAAEQARQKElEQRAAAEKAAKQ-----AEQAAKQAEEKQKQAEEAKA 126

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578821371  612 KAKEERlaeekakkkaaaKKMEEVEARRKQEEEARRlrwlqqvraqeeeerrhQELLQKKKEEEQERLRKAAEAKRLA 689
Cdd:TIGR02794 127 KQAAEA------------KAKAEAEAERKAKEEAAK-----------------QAEEEAKAKAAAEAKKKAEEAKKKA 175
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 533-785 9.52e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 43.04  E-value: 9.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   533 SFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEK--- 609
Cdd:pfam02463  747 EEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLieq 826

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   610 TEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQVRAQEEEERRHQELLQKK--KEEEQERLRKAAEAKR 687
Cdd:pfam02463  827 EEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELesKEEKEKEEKKELEEES 906

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   688 LAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLqaeRELQEREKALRLQKEQLQRE-----LEEK 762
Cdd:pfam02463  907 QKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENN---KEEEEERNKRLLLAKEELGKvnlmaIEEF 983

                          250       260
                   ....*....|....*....|...
gi 578821371   763 KKKEEQQRLAERQLQEEQEKKAK 785
Cdd:pfam02463  984 EEKEERYNKDELEKERLEEEKKK 1006
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 536-684 1.02e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.13  E-value: 1.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   536 EKERQRLENLRRKEEAEQLRR----------QKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQ 605
Cdd:TIGR02169  332 DKLLAEIEELEREIEEERKRRdklteeyaelKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRL 411

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   606 IDEKTEkaKEERLAEEKAKKKAAAKKMEEVEARRKQ-EEEARRLRW-LQQVRAQEEEERRHQELLQKKKEEEQERLRKAA 683
Cdd:TIGR02169  412 QEELQR--LSEELADLNAAIAGIEAKINELEEEKEDkALEIKKQEWkLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQ 489


                   .
gi 578821371   684 E 684
Cdd:TIGR02169  490 R 490
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 540-647 1.07e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 42.89  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 540 QRLENLRRkeEAEQlrrqkveedKRRRLEEvKLKREERLRKVLQAR-ERVEQMKEEKKKQIEQKFAQIdekTEKAKEERL 618
Cdd:PRK00409 523 ASLEELER--ELEQ---------KAEEAEA-LLKEAEKLKEELEEKkEKLQEEEDKLLEEAEKEAQQA---IKEAKKEAD 587

                         90       100
                 ....*....|....*....|....*....
gi 578821371 619 AEEKAKKKAAAKKMEEVeaRRKQEEEARR 647
Cdd:PRK00409 588 EIIKELRQLQKGGYASV--KAHELIEARK 614
RNase_Y_N pfam12072
RNase Y N-terminal region;
535-615 1.14e-03

RNase Y N-terminal region;


Pssm-ID: 463456 [Multi-domain]  Cd Length: 201  Bit Score: 41.02  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  535 VEKERQRLENLRR------KEEAEQLRRQKVEEDKRRR-----LEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKF 603
Cdd:pfam12072  40 IEEAKKEAETKKKealleaKEEIHKLRAEAERELKERRnelqrQERRLLQKEETLDRKDESLEKKEESLEKKEKELEAQQ 119

                          90
                  ....*....|..
gi 578821371  604 AQIDEKTEKAKE 615
Cdd:pfam12072 120 QQLEEKEEELEE 131
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
 531-785 1.43e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 464007 [Multi-domain]  Cd Length: 341  Bit Score: 41.83  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  531 KCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKfaQIDEKT 610
Cdd:pfam13868  55 RALEEEEEKEEERKEERKRYRQELEEQIEEREQKRQEEYEEKLQEREQMDEIVERIQEEDQAEAEEKLEKQR--QLREEI 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  611 EKAKEERLAEEKakkkaaakkmeeVEARRKQEEEARRLRWLQQVRAQEEEERRHQELLQKKKEEEQERLRKAAEAKRlae 690
Cdd:pfam13868 133 DEFNEEQAEWKE------------LEKEEEREEDERILEYLKEKAEREEEREAEREEIEEEKEREIARLRAQQEKAQ--- 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  691 qreqerREQERREQERREQERREQERREQERQLAEQERRR-EQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 769
Cdd:pfam13868 198 ------DEKAERDELRAKLYQEEQERKERQKEREEAEKKArQRQELQQAREEQIELKERRLAEEAEREEEEFERMLRKQA 271

                         250
                  ....*....|....*.
gi 578821371  770 RLAERQLQEEQEKKAK 785
Cdd:pfam13868 272 EDEEIEQEEAEKRRMK 287
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 506-786 1.49e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 42.65  E-value: 1.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   506 MTPTSAPRSVMKSfiKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQAR 585
Cdd:pfam02463  650 KGVSLEEGLAEKS--EVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRV 727

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   586 ERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQVRAQEEEERRHQ 665
Cdd:pfam02463  728 QEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALE 807

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   666 ELLQKKKE--EEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQE 743
Cdd:pfam02463  808 EELKEEAEllEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDE 887

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 578821371   744 REKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 786
Cdd:pfam02463  888 LESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEIL 930
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 141-287 1.76e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 42.00  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 141 PSSPTPESPTMLTK---KPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTPASATAPTSQ----GIPT 213
Cdd:PRK08691 380 PSAQTAEKETAAKKpqpRPEAETAQTPVQTASAAAMPSEGKTAGPVSNQENNDVPPWEDAPDEAQTAAGTAQtsakSIQT 459

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578821371 214 SDEESTPKK---SKARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPG-PRDSPAFPDSPWRERVLAPILP 287
Cdd:PRK08691 460 ASEAETPPEnqvSKNKAADNETDAPLSEVPSENPIQATPNDEAVETETFAHEAPAePFYGYGFPDNDCPPEDGAEIPP 537
PRK12704 PRK12704
phosphodiesterase; Provisional
 549-686 2.13e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 41.69  E-value: 2.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 549 EEAEQLRRQKVEEDKRrrleEVKLKREErlrKVLQARERVEQMKEEKKKQIEQKFAQID--EKTEKAKEERLAEEKakkk 626
Cdd:PRK12704  34 KEAEEEAKRILEEAKK----EAEAIKKE---ALLEAKEEIHKLRNEFEKELRERRNELQklEKRLLQKEENLDRKL---- 102

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578821371 627 aaakkmeevEARRKQEEEARRLRwlQQVRAQEEEERRHQELLQKKKEEEQERLRKAA-----EAK 686
Cdd:PRK12704 103 ---------ELLEKREEELEKKE--KELEQKQQELEKKEEELEELIEEQLQELERISgltaeEAK 156
ERM_helical pfam20492
Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related ...
 541-649 2.30e-03

Ezrin/radixin/moesin, alpha-helical domain; The ERM family consists of three closely-related proteins, ezrin, radixin and moesin. Ezrin was first identified as a constituent of microvilli, radixin as a barbed, end-capping actin-modulating protein from isolated junctional fractions, and moesin as a heparin binding protein. A tumour suppressor molecule responsible for neurofibromatosis type 2 (NF2) is highly similar to ERM proteins and has been designated merlin (moesin-ezrin-radixin-like protein). ERM molecules contain 3 domains, an N-terminal globular domain, an extended alpha-helical domain and a charged C-terminal domain (pfam00769). Ezrin, radixin and merlin also contain a polyproline linker region between the helical and C-terminal domains. The N-terminal domain is highly conserved and is also found in merlin, band 4.1 proteins and members of the band 4.1 superfamily, designated the FERM domain. ERM proteins crosslink actin filaments with plasma membranes. They co-localize with CD44 at actin filament plasma membrane interaction sites, associating with CD44 via their N-terminal domains and with actin filaments via their C-terminal domains. This is the alpha-helical domain, which is involved in intramolecular masking of protein-protein interaction sites, regulating the activity of this proteins.


Pssm-ID: 466641 [Multi-domain]  Cd Length: 120  Bit Score: 38.75  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  541 RLENLRRKEEAEQLRRQKVEEDKR-----RRLEEVKLKREERLRKVLQARERVEQmkeeKKKQIEQKFAQIDEKTEKAKE 615
Cdd:pfam20492   1 REEAEREKQELEERLKQYEEETKKaqeelEESEETAEELEEERRQAEEEAERLEQ----KRQEAEEEKERLEESAEMEAE 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 578821371  616 ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 649
Cdd:pfam20492  77 EKEQLEAELAEAQEEIARLEEEVERKEEEARRLQ 110
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 531-679 4.00e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.88  E-value: 4.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  531 KCSFVEKERQR--------LENLRR-KEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEK----KK 597
Cdd:pfam17380 403 KVKILEEERQRkiqqqkveMEQIRAeQEEARQREVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKleleKE 482

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  598 QIEQKFAQIDEKT--EKAKEERLAEEKAKKKAAAKKMEEVEARRKQ--EEEARRLRWLQQVRAQEEEERRHQELLQKKKE 673
Cdd:pfam17380 483 KRDRKRAEEQRRKilEKELEERKQAMIEEERKRKLLEKEMEERQKAiyEEERRREAEEERRKQQEMEERRRIQEQMRKAT 562


                  ....*.
gi 578821371  674 EEQERL 679
Cdd:pfam17380 563 EERSRL 568
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 535-804 4.09e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.20  E-value: 4.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   535 VEKERQRLENLrrKEEAEQLRRQKVE-EDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKA 613
Cdd:TIGR02168  283 IEELQKELYAL--ANEISRLEQQKQIlRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAEL 360

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   614 KEERlaeEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQVRAQEEEERRHQELLQKKKE---EEQERLRKAAEAKRLAE 690
Cdd:TIGR02168  361 EELE---AELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRErlqQEIEELLKKLEEAELKE 437

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371   691 QREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQaERELQEREKALRLQKEQLQRE--------LEEK 762
Cdd:TIGR02168  438 LQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERE-LAQLQARLDSLERLQENLEGFsegvkallKNQS 516

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 578821371   763 KKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDVQSPA 804
Cdd:TIGR02168  517 GLSGILGVLSELISVDEGYEAAIEAALGGRLQAVVVENLNAA 558
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 536-649 4.77e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.69  E-value: 4.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 536 EKERQRLENLRRKEEAEQLRRQKVEEdkRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKE 615
Cdd:COG1196  666 SRRELLAALLEAEAELEELAERLAEE--ELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLE 743

                         90       100       110
                 ....*....|....*....|....*....|....
gi 578821371 616 ERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLR 649
Cdd:COG1196  744 EEELLEEEALEELPEPPDLEELERELERLEREIE 777
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 142-513 5.21e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 40.67  E-value: 5.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  142 SSPTPE------SPTMLTKKPEDNHTqcqlvpvveigisERQNAEQHVTQLMSTEPLPRTLSPTPAsATAPTSQGIPTSD 215
Cdd:pfam05109 474 TSPTPAgttsgaSPVTPSPSPRDNGT-------------ESKAPDMTSPTSAVTTPTPNATSPTPA-VTTPTPNATSPTL 539

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  216 EESTPKKSKARILESITVSSLMATPQDPKGQGVGTGRSASKLRIAQVSPGPrDSPAFPDSPWRERVLAPILPDNFSTPTG 295
Cdd:pfam05109 540 GKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNA-TSPTVGETSPQANTTNHTLGGTSSTPVV 618

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  296 SrtdsQSVRHSPIAPSSPSPQVLAQKYSLVAKQESVVrraSRRLAKKTAEEPAASGRIICHSYLERLLNVEVPQKVGSEQ 375
Cdd:pfam05109 619 T----SPPKNATSAVTTGQHNITSSSTSSMSLRPSSI---SETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTST 691

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  376 KEPPEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPAASSPETPSAGQQEAKTDQADGPREPPQSARRKRSYKQ 455
Cdd:pfam05109 692 HHVSTSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPKNATSPQAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHG 771

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578821371  456 AVSELDEEQHLEDEElQPPRSK---TPSSPCPASKVVRPLRTFLH---TVQRNQMLMTPTSAPR 513
Cdd:pfam05109 772 ARTSTEPTTDYGGDS-TTPRTRynaTTYLPPSTSSKLRPRWTFTSppvTTAQATVPVPPTSQPR 834
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 538-687 6.26e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.31  E-value: 6.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 538 ERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEER 617
Cdd:COG1196  628 VAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEER 707

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 618 LAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQvRAQEEEERRHQELLQKKKEEEQERLRKAAEAKR 687
Cdd:COG1196  708 ELAEAEEERLEEELEEEALEEQLEAEREELLEELLE-EEELLEEEALEELPEPPDLEELERELERLEREI 776
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 536-788 6.37e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.31  E-value: 6.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 536 EKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKE---EKKKQIEQKFAQIDEKTEK 612
Cdd:COG1196  406 EEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLEllaELLEEAALLEAALAELLEE 485

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 613 AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARR--------LRWLQQVRAQEEEERRHQELLQKKKEEEQERLRKAAE 684
Cdd:COG1196  486 LAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRglagavavLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEY 565

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 685 AKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER-------EKALRLQKEQLQR 757
Cdd:COG1196  566 LKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRtlvaarlEAALRRAVTLAGR 645

                        250       260       270
                 ....*....|....*....|....*....|.
gi 578821371 758 ELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 788
Cdd:COG1196  646 LREVTLEGEGGSAGGSLTGGSRRELLAALLE 676
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 536-617 6.51e-03

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 38.10  E-value: 6.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  536 EKERQRLENLRRKEEAEQLRR----QKVEEDKRRRLEEVKLKREERLRKVLQaRERVEQMKEEKKKQIEQKFAQidEKTE 611
Cdd:pfam05672  39 EEERLRKEELRRRAEEERARReeeaRRLEEERRREEEERQRKAEEEAEEREQ-REQEEQERLQKQKEEAEAKAR--EEAE 115


                  ....*.
gi 578821371  612 KAKEER 617
Cdd:pfam05672 116 RQRQER 121
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
525-687 6.76e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 40.41  E-value: 6.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 525 PLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEdKRRRLEEVKlKREERLRKVLQARERVEQMKEEKKKQIEQKFA 604
Cdd:PRK02224 460 PVEGSPHVETIEEDRERVEELEAELEDLEEEVEEVEE-RLERAEDLV-EAEDRIERLEERREDLEELIAERRETIEEKRE 537

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371 605 QIDEKTEKA---------KEERLAEEKAKKKAAAKKMEEVEARRKQEEEAR-RLRWLQQVRAQEEEERRHQELLQKKKE- 673
Cdd:PRK02224 538 RAEELRERAaeleaeaeeKREAAAEAEEEAEEAREEVAELNSKLAELKERIeSLERIRTLLAAIADAEDEIERLREKREa 617

                        170       180
                 ....*....|....*....|
gi 578821371 674 ------EEQERLRKAAEAKR 687
Cdd:PRK02224 618 laelndERRERLAEKRERKR 637
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
 534-617 6.90e-03

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 40.32  E-value: 6.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  534 FVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLqarERVEQMKEEKKKQIEQKFAQIDEKTEKA 613
Cdd:PRK11448  134 FVPPEDPENLLHALQQEVLTLKQQLELQAREKAQSQALAEAQQQELVAL---EGLAAELEEKQQELEAQLEQLQEKAAET 210


                  ....
gi 578821371  614 KEER 617
Cdd:PRK11448  211 SQER 214
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is ...
 538-675 9.23e-03

MAP7 (E-MAP-115) family; The organization of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilising protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 461709 [Multi-domain]  Cd Length: 153  Bit Score: 37.71  E-value: 9.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821371  538 ERQRLENLRRKEEaEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEER 617
Cdd:pfam05672  18 EKRRQAREQRERE-EQERLEKEEEERLRKEELRRRAEEERARREEEARRLEEERRREEEERQRKAEEEAEEREQREQEEQ 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 578821371  618 LAEEKAKKkaaakkmeevEARRKQEEEARRLRwlqQVRAQEEEERRHQELLQKKKEEE 675
Cdd:pfam05672  97 ERLQKQKE----------EAEAKAREEAERQR---QEREKIMQQEEQERLERKKRIEE 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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