NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|578819535|ref|XP_006717946|]
View 

calcium homeostasis modulator protein 2 isoform X1 [Homo sapiens]

Protein Classification

calcium homeostasis modulator protein( domain architecture ID 10632259)

calcium homeostasis modulator protein is a pore-forming subunit of a voltage-gated ion channel that may be permeable to monovalent cations, divalent cations, and anions; it acts as a major ATP release channel, and may have an important role in gustatory signalling and neuronal toxicity

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Ca_hom_mod pfam14798
Calcium homeostasis modulator; This family of proteins control cytosolic calcium concentration. ...
 7-256 1.33e-108

Calcium homeostasis modulator; This family of proteins control cytosolic calcium concentration. They are transmembrane proteins which may be pore-forming ion channels.


:

Pssm-ID: 464320  Cd Length: 248  Bit Score: 316.11  E-value: 1.33e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819535    7 ENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTWNLVAEC 86
Cdd:pfam14798   1 DKFRTVLQFFQSHKESLGNGLVALLTAGGERIFSSVVFQCPCSPGYNFLYGLVFLLVPALVLFLLGYLLNTRTWRLLTGC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819535   87 QhRRTKNCSAAPTFL--LLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAreehFPSAHATEILARFPCKE 164
Cdd:pfam14798  81 C-RPTGKRSKRPACLryVFGSITVRALVAPLTWLAVALLDGEFYECAGSEFVDPAKFLC----KTSSCAAEELAKVPCKK 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819535  165 NPD-NLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSRVLA 243
Cdd:pfam14798 156 SVLpPVDDEREELLRYLRAQSQILGWLLIAVIILLAFLATCLSRCFSPVSYLQLKYWKNYLEKEQELFEETAKEHARQLA 235

                         250
                  ....*....|...
gi 578819535  244 ANNVRRFFGFVAL 256
Cdd:pfam14798 236 KRNVKCFFESSQP 248
 
Name Accession Description Interval E-value
Ca_hom_mod pfam14798
Calcium homeostasis modulator; This family of proteins control cytosolic calcium concentration. ...
 7-256 1.33e-108

Calcium homeostasis modulator; This family of proteins control cytosolic calcium concentration. They are transmembrane proteins which may be pore-forming ion channels.


Pssm-ID: 464320  Cd Length: 248  Bit Score: 316.11  E-value: 1.33e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819535    7 ENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTWNLVAEC 86
Cdd:pfam14798   1 DKFRTVLQFFQSHKESLGNGLVALLTAGGERIFSSVVFQCPCSPGYNFLYGLVFLLVPALVLFLLGYLLNTRTWRLLTGC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819535   87 QhRRTKNCSAAPTFL--LLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAreehFPSAHATEILARFPCKE 164
Cdd:pfam14798  81 C-RPTGKRSKRPACLryVFGSITVRALVAPLTWLAVALLDGEFYECAGSEFVDPAKFLC----KTSSCAAEELAKVPCKK 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819535  165 NPD-NLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSRVLA 243
Cdd:pfam14798 156 SVLpPVDDEREELLRYLRAQSQILGWLLIAVIILLAFLATCLSRCFSPVSYLQLKYWKNYLEKEQELFEETAKEHARQLA 235

                         250
                  ....*....|...
gi 578819535  244 ANNVRRFFGFVAL 256
Cdd:pfam14798 236 KRNVKCFFESSQP 248
 
Name Accession Description Interval E-value
Ca_hom_mod pfam14798
Calcium homeostasis modulator; This family of proteins control cytosolic calcium concentration. ...
 7-256 1.33e-108

Calcium homeostasis modulator; This family of proteins control cytosolic calcium concentration. They are transmembrane proteins which may be pore-forming ion channels.


Pssm-ID: 464320  Cd Length: 248  Bit Score: 316.11  E-value: 1.33e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819535    7 ENFRFLSLFFKSKDVMIFNGLVALGTVGSQELFSVVAFHCPCSPARNYLYGLAAIGVPALVLFIIGIILNNHTWNLVAEC 86
Cdd:pfam14798   1 DKFRTVLQFFQSHKESLGNGLVALLTAGGERIFSSVVFQCPCSPGYNFLYGLVFLLVPALVLFLLGYLLNTRTWRLLTGC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819535   87 QhRRTKNCSAAPTFL--LLSSILGRAAVAPVTWSVISLLRGEAYVCALSEFVDPSSLTAreehFPSAHATEILARFPCKE 164
Cdd:pfam14798  81 C-RPTGKRSKRPACLryVFGSITVRALVAPLTWLAVALLDGEFYECAGSEFVDPAKFLC----KTSSCAAEELAKVPCKK 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578819535  165 NPD-NLSDFREEVSRRLRYESQLFGWLLIGVVAILVFLTKCLKHYCSPLSYRQEAYWAQYRANEDQLFQRTAEVHSRVLA 243
Cdd:pfam14798 156 SVLpPVDDEREELLRYLRAQSQILGWLLIAVIILLAFLATCLSRCFSPVSYLQLKYWKNYLEKEQELFEETAKEHARQLA 235

                         250
                  ....*....|...
gi 578819535  244 ANNVRRFFGFVAL 256
Cdd:pfam14798 236 KRNVKCFFESSQP 248
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH