|
Name |
Accession |
Description |
Interval |
E-value |
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
221-619 |
9.34e-12 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 69.58 E-value: 9.34e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 221 PRLPQAGARDPPVHLLQASSSAQSTPGHLFPNVPAQEASKSASHKGSRRLASSRVERTLPQASLLASTGPRPKPKTVSEL 300
Cdd:PHA03247 2616 PLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSL 2695
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 301 LQEKRLQEARAREATRGPVV---LPSQLLVSSSVILQPPLPHTPHGRPAPGPTVLNVPLSGPGAPAAakpgTSGSwqEAG 377
Cdd:PHA03247 2696 TSLADPPPPPPTPEPAPHALvsaTPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT----TAGP--PAP 2769
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 378 TSAKDKRLSTMQALPLAPVFSEAEgTAPAASQAPALGPGQISVSCPESGLGQSQAPAAsrkqGLPEAPPFLPAAPSPTPL 457
Cdd:PHA03247 2770 APPAAPAAGPPRRLTRPAVASLSE-SRESLPSPWDPADPPAAVLAPAAALPPAASPAG----PLPPPTSAQPTAPPPPPG 2844
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 458 PVQPlSLTHIGGPHVATSVPLPVTWVLTAQGLLPVPVPAVVSLPRPAGTPGPAgLLATLLPPLTETRAAQGPRAPALSSS 537
Cdd:PHA03247 2845 PPPP-SLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTE-SFALPPDQPERPPQPQAPPPPQPQPQ 2922
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 538 WQPPANMNREPEPSCRTDTPAPPThALSQSPAEADGSVAFVPGEAQVAREIPEPRTSSHADPPEAEPPWSGRLPAFGGVI 617
Cdd:PHA03247 2923 PPPPPQPQPPPPPPPRPQPPLAPT-TDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSL 3001
|
..
gi 578817794 618 PA 619
Cdd:PHA03247 3002 SR 3003
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
225-619 |
1.44e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 65.73 E-value: 1.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 225 QAGARDPPVHLLQASSSAQSTPGHLFPNVPAQEASKSASHKGSRRLASSRVERTLPQASLLASTGPRPKPKTVSELLQEK 304
Cdd:PHA03247 2583 TSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVS 2662
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 305 RLQEAR-------AREATRGPVVLPSQLLVSSSVILQPPLPHTPHGRPAPGPTVLNVPLS-GPGAPAAAKPGTSGSWQEA 376
Cdd:PHA03247 2663 RPRRARrlgraaqASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPpGPAAARQASPALPAAPAPP 2742
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 377 GTSAKdkrlstmqalPLAPVFSEAEGTAPAASQAPALGPGQISVSCPESGLgqSQAPAASRKQGLPEAPpfLPAAPSPTP 456
Cdd:PHA03247 2743 AVPAG----------PATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRL--TRPAVASLSESRESLP--SPWDPADPP 2808
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 457 LPVQPLSLTHIGGPHVATSVPLPVTWVLTAQGLLPVPVPAVVSlprPAGTPGPAGLLATLLPPLTETRAAQGPRAPALSS 536
Cdd:PHA03247 2809 AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP---LGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRR 2885
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 537 SWQPPANMNREPEPSCRTDTPAPPTHALSQSPAEAdgsvafvPGEAQVAREIPEPRTSSHADPPEAEPPWSGRLPAFGGV 616
Cdd:PHA03247 2886 LARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQ-------PQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGA 2958
|
...
gi 578817794 617 IPA 619
Cdd:PHA03247 2959 VPQ 2961
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
290-711 |
4.21e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 60.72 E-value: 4.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 290 PRPKPKTVSELLQEKRLQEARAREATRGPVVLPSQLLVSSSVILQPPLPHTPHgRPAPGPTVLNVPLSGPGaPAAAKPGT 369
Cdd:PHA03247 2573 PAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPD-PPPPSPSPAANEPDPHP-PPTVPPPE 2650
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 370 SGSWQEAGTSAKDKRLSTMQALPLAPVfSEAEGTAPAASQAP-------ALGPGQISVSCPESGLGQSQAPAASRKQGLP 442
Cdd:PHA03247 2651 RPRDDPAPGRVSRPRRARRLGRAAQAS-SPPQRPRRRAARPTvgsltslADPPPPPPTPEPAPHALVSATPLPPGPAAAR 2729
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 443 EAPPFLPAAPSPTPLPVQPLSlthIGGPHVATSVPLPVTWVLTAQGLLPVPVPAVVSLPRPAGTPGPAGLLATLLPPLTE 522
Cdd:PHA03247 2730 QASPALPAAPAPPAVPAGPAT---PGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPAD 2806
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 523 TRAAQGPRAPALSSSWQPPANmnrEPEPSCRTDTPAPPTHALSQSPAEADGSVAfvPGeAQVAREIP------------E 590
Cdd:PHA03247 2807 PPAAVLAPAAALPPAASPAGP---LPPPTSAQPTAPPPPPGPPPPSLPLGGSVA--PG-GDVRRRPPsrspaakpaapaR 2880
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 591 PRTSSHADPPEAEPPWSGRLPAFGgviPATEPRGTPGSPSGTQEPRGPLGLEKLPLRQPGPEKGALDLEKPPLPQPGPEK 670
Cdd:PHA03247 2881 PPVRRLARPAVSRSTESFALPPDQ---PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSG 2957
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 578817794 671 GALDlgllsqegeaatqQWLGGQRGVRVPLLGSRLPYQPPA 711
Cdd:PHA03247 2958 AVPQ-------------PWLGALVPGRVAVPRFRVPQPAPS 2985
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
305-671 |
1.21e-07 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 55.84 E-value: 1.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 305 RLQEARAREATRGPVVL----PSQLLVSSSVILQPPLPHTPHgRPAPGPTVLNVPLSGPGAPAAAKPGTSGSWQEAGTSA 380
Cdd:PHA03378 437 RTEQPRATPHSQAPTVVlhrpPTQPLEGPTGPLSVQAPLEPW-QPLPHPQVTPVILHQPPAQGVQAHGSMLDLLEKDDED 515
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 381 KDKRLSTMQALPLAP----------VFSE---AEGTAPAASQA------PALGPGQISV-------------SCPESGLG 428
Cdd:PHA03378 516 MEQRVMATLLPPSPPqpragrrapcVYTEdldIESDEPASTEPvhdqllPAPGLGPLQIqpltspttsqlasSAPSYAQT 595
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 429 QSQAPAASRKQGLPEAPPFLPA--APSPTPLPVQPLSLTHIGGPHVATSVPLPVTWVLTAQGLLPVPVPAVVSLPRPAGT 506
Cdd:PHA03378 596 PWPVPHPSQTPEPPTTQSHIPEtsAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQ 675
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 507 PGPAGLLATLLPPLTETRAAQGPRAPALSSSWQPPANMNREPEPSCRTDTPAPPTHALSQSPAEADGSV---AFVPGEAQ 583
Cdd:PHA03378 676 PSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRArppAAAPGRAR 755
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 584 VAREIPEPRTSSHADPPEAEPpwsgRLPAFGGVIPATEPRgtpGSPSGTQEPRGPLGLEKLPLRQPGPEKGALDLEKPPL 663
Cdd:PHA03378 756 PPAAAPGRARPPAAAPGAPTP----QPPPQAPPAPQQRPR---GAPTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQL 828
|
....*...
gi 578817794 664 PQPGPEKG 671
Cdd:PHA03378 829 LTGGVKRG 836
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
335-666 |
1.53e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.17 E-value: 1.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 335 PPLPHTPHGRPAPGPTVLNVPLSGPGAPAAAKPGTSGSWQEAGTSAKDKrlstmqALPLAPVFSEAEGTAPAASQAPALG 414
Cdd:PHA03247 2503 PPDPDAPPAPSRLAPAILPDEPVGEPVHPRMLTWIRGLEELASDDAGDP------PPPLPPAAPPAAPDRSVPPPRPAPR 2576
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 415 PGQISVSCPESGLGQSQAPAASRKQGLPEAPPFLPAAPSPTPLPVQPLSLTHIGGPHVATSVPLPVTWVLTA-QGLLPVP 493
Cdd:PHA03247 2577 PSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPpERPRDDP 2656
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 494 VPAVVSLPRPAGTPGPAGLLATLLppltetraaQGPRAPALSSSWQPPANMNREPEPScrtDTPAPPTHALSqspaeadg 573
Cdd:PHA03247 2657 APGRVSRPRRARRLGRAAQASSPP---------QRPRRRAARPTVGSLTSLADPPPPP---PTPEPAPHALV-------- 2716
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 574 SVAFVPGEAQVAREIPEPRTSSHADPPEAEPPwsgrlPAFGGVIPATEPRGTPGSPSGTqEPRGPLGLEklPLRQPGPEK 653
Cdd:PHA03247 2717 SATPLPPGPAAARQASPALPAAPAPPAVPAGP-----ATPGGPARPARPPTTAGPPAPA-PPAAPAAGP--PRRLTRPAV 2788
|
330
....*....|...
gi 578817794 654 GALDLEKPPLPQP 666
Cdd:PHA03247 2789 ASLSESRESLPSP 2801
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
218-604 |
1.98e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 48.44 E-value: 1.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 218 ALPPRLPQAGARDPPVhlLQASSSAQSTPghlfPNVPAQEASKSASHKGSRRLASSrvertlPQASLLASTGPRPKPKTV 297
Cdd:PRK07764 380 RLERRLGVAGGAGAPA--AAAPSAAAAAP----AAAPAPAAAAPAAAAAPAPAAAP------QPAPAPAPAPAPPSPAGN 447
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 298 SELLQEKRLQEARAREATRGPVVLPSQllvssSVILQPPLPHTPHGRPAPGPTVLNVPLSGPGAPAAAKPgtSGSWQEAG 377
Cdd:PRK07764 448 APAGGAPSPPPAAAPSAQPAPAPAAAP-----EPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATL--RERWPEIL 520
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 378 TSAKDKRLSTMQAL---------------------PLAPVFSEAE-----------------------GTAPAASQAPAL 413
Cdd:PRK07764 521 AAVPKRSRKTWAILlpeatvlgvrgdtlvlgfstgGLARRFASPGnaevlvtalaeelggdwqveavvGPAPGAAGGEGP 600
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 414 GPGQISVSCPESGLGQSQAPAASRKQGLPEAPPFLPAAPSPTPLPVQPLSLTHIGGPHVATSVPLPVTWVLTAQGLLPV- 492
Cdd:PRK07764 601 PAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAa 680
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 493 PVPAVVSLPRPAGTPGPAGLLATLLPPlteTRAAQGPRAPAlsSSWQPPANMNREPEPSCRTDTPAPPTHALSQSPAEAD 572
Cdd:PRK07764 681 PPPAPAPAAPAAPAGAAPAQPAPAPAA---TPPAGQADDPA--AQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAP 755
|
410 420 430
....*....|....*....|....*....|..
gi 578817794 573 GSVAFVPGEAQVAREIPEPRTSSHADPPEAEP 604
Cdd:PRK07764 756 AQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAE 787
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
364-574 |
2.97e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 47.95 E-value: 2.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 364 AAKPGTSGSWQEAGTSAKDKRLSTMQAL----PLAPVFSEAEGTAPAASQAPALGPGQISVSCPESGLGQSQAPAASRKQ 439
Cdd:PRK12323 362 AFRPGQSGGGAGPATAAAAPVAQPAPAAaapaAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASA 441
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 440 GLPEAPPFLPAAPSPTPLPVQPLSLTHIGGPHVATSVPLPVTWVLTAQGLLPVPVPAVVSLPRPAGTPGP----AGLLAT 515
Cdd:PRK12323 442 RGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPaqpdAAPAGW 521
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 578817794 516 LLPPLTETRAAQGPRAPALSSSWQPPANMNREPEPSCRTDTPAPPTHALSQSPAEADGS 574
Cdd:PRK12323 522 VAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGD 580
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
334-668 |
7.81e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 46.52 E-value: 7.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 334 QPPLPHTPHGRPAPGPtvlnvplSGPGAPAAAKPGTSGSWQEAGT-SAKDKRLSTMQALPLAPVFSEAEGTAPAASQAPA 412
Cdd:PRK07764 397 AAPSAAAAAPAAAPAP-------AAAAPAAAAAPAPAAAPQPAPApAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPA 469
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 413 LGPGQISVSCPESGLGQSQAPAASRKQGLPEAPPFLPAA---------------------------PSPTPLPVQP--LS 463
Cdd:PRK07764 470 PAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDaatlrerwpeilaavpkrsrktwaillPEATVLGVRGdtLV 549
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 464 LTH--------IGGPHVATSVplpvTWVLTAQGLLPVPVPAVVSLPRPAGTPGPAGLLATLLPPLTETRAAQGPRAPALS 535
Cdd:PRK07764 550 LGFstgglarrFASPGNAEVL----VTALAEELGGDWQVEAVVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPA 625
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 536 SSWQPPANMNREPEPSCRTDTPAPPTHALSQSPAEA-----DGSVAFVPGEAQVAREIPEPRTSSHADPPEAEPPWSGRL 610
Cdd:PRK07764 626 APAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDasdggDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAP 705
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 578817794 611 PAFGGVIPATEPRGTPGSPSGTQEPRGPLGLEKLPLRQPGPEKGALDLEKPPLPQPGP 668
Cdd:PRK07764 706 AATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPA 763
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
344-542 |
8.86e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 46.41 E-value: 8.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 344 RPAPGPTVLNVPLSGPGAPAAAKPGTSGSWQEAGTSAKDKRLSTMQALPLApvfSEAEGTAPAASQAPALGPGQISVSCP 423
Cdd:PRK12323 386 APAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAA---RQASARGPGGAPAPAPAPAAAPAAAA 462
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 424 ESGLGQSQAPAASRKQGLPEAPPFLPAAPSPTPLPVQPLSLTHIGGPHVATSVPLPVTWVLTAqglLPVPVPAVVSLPRP 503
Cdd:PRK12323 463 RPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAES---IPDPATADPDDAFE 539
|
170 180 190
....*....|....*....|....*....|....*....
gi 578817794 504 AGTPGPAGLLATLLPPLTETRAAqgPRAPALSSSWQPPA 542
Cdd:PRK12323 540 TLAPAPAAAPAPRAAAATEPVVA--PRPPRASASGLPDM 576
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
391-631 |
9.33e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 46.02 E-value: 9.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 391 LPLAPVFSEAEGTAPAASQAPALGPgqisvscpesglgqsqAPAASRKQGLPEAPPFLPAAPSPTPlPVQPLSLTHIGGP 470
Cdd:PRK12323 361 LAFRPGQSGGGAGPATAAAAPVAQP----------------APAAAAPAAAAPAPAAPPAAPAAAP-AAAAAARAVAAAP 423
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 471 HVATSVPLPVTWVLTAQGLLPVPVPAVVSLPRPAGTPGPAGLLATLLPPLTETRAAQGPRAPALSSSWQPPANMNREPEP 550
Cdd:PRK12323 424 ARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELP 503
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 551 ScrtDTPAPPTHALSQSPAEADGSVAFVPGEAQVAREIPEPRTSSHADPpeAEPPWSGRLPAFGGVIPATEPRGTPGSPS 630
Cdd:PRK12323 504 P---EFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAP--APRAAAATEPVVAPRPPRASASGLPDMFD 578
|
.
gi 578817794 631 G 631
Cdd:PRK12323 579 G 579
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
335-631 |
9.82e-05 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 46.32 E-value: 9.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 335 PPLPHTPHGRPAPGPTVLNVPLSGPGAPAAAKPGTSGSWQEAGTSAKDKRLSTMQALPLAPVFSEAEGTAPAASQAPALG 414
Cdd:PHA03307 132 PDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSS 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 415 PGQISVSCPESGLGQSQA---------PAASRKQGLPEAPPFLPAAPSPTPLPVQPLSLTHIgGPHVATSVPLPVTWVLT 485
Cdd:PHA03307 212 PISASASSPAPAPGRSAAddagasssdSSSSESSGCGWGPENECPLPRPAPITLPTRIWEAS-GWNGPSSRPGPASSSSS 290
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 486 AQGLLPVPVPAVVSLPRPAGTPGPAGLLATLLPPLTETRAAQGP-RAPALSSSWQPPANMNREPEPSCRTDTPAPPTHAL 564
Cdd:PHA03307 291 PRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSEsSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPR 370
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578817794 565 SQSPAEADGSVAFVPGEAQVAREIPEPRTSSHADPPEAEPPWSGRLPAFGGVIPATEPRGTPGSPSG 631
Cdd:PHA03307 371 PSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLTPSG 437
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
404-674 |
1.03e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 46.00 E-value: 1.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 404 APAASQAPAlGPGQISVSCPESGLGQSQAPAASRKQGLPEAPPFLPAAPSPTPLPVQPLSLTHIGGPHVAtsvPLPVTWV 483
Cdd:PRK07003 361 AVTGGGAPG-GGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAA---PAPPATA 436
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 484 LTAQGLLPVPVPAVVSLPRPAGTPGPAGLLATLLPPLTETRAAQGPRAPALSSswqppanmnREPEPSCrtdtpAPPTHA 563
Cdd:PRK07003 437 DRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAA---------FEPAPRA-----AAPSAA 502
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 564 LSQSPAEADGSVAFVPGEAQVAREIPEPRTSShADPPEAEPPWSGrlpafGGVIPATEPRGTPGSPSGTQEPRGPLGLEK 643
Cdd:PRK07003 503 TPAAVPDARAPAAASREDAPAAAAPPAPEARP-PTPAAAAPAARA-----GGAAAALDVLRNAGMRVSSDRGARAAAAAK 576
|
250 260 270
....*....|....*....|....*....|.
gi 578817794 644 LPLRQPGPEKGALDLEKPPLPQPGPEKGALD 674
Cdd:PRK07003 577 PAAAPAAAPKPAAPRVAVQVPTPRARAATGD 607
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
329-634 |
1.28e-04 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 45.72 E-value: 1.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 329 SSVILQPPLPHTPHGRPAPGPTVLNVPLS-GPGAPAAAKPGTSGSwqeAGTSAKDKRLSTMQALPLAPVFSEAEGTAPAA 407
Cdd:pfam17823 111 ASRALAAAASSSPSSAAQSLPAAIAALPSeAFSAPRAAACRANAS---AAPRAAIAAASAPHAASPAPRTAASSTTAASS 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 408 SQAPALGPGQISVSCPESGLGQSQAPAASRKQGLPEAPPFLPAAPSPTPLPVQPLSLTHIGGPHVATSVPLPVTWVLTAQ 487
Cdd:pfam17823 188 TTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAA 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 488 GLLPVPVPAVVSLPRPAGTPGPAGLLATLLPPLTETraaQGPRAPAlsSSWQPPANMNREPEPSCRTDTPAPPTHALSQS 567
Cdd:pfam17823 268 GTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQA---QGPIIQV--STDQPVHNTAGEPTPSPSNTTLEPNTPKSVAS 342
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578817794 568 PAEADGSVAFVPGEAQVAREIPEPRTSShadPPEAEPPWSGRLPAfggVIPATEPRGTPGSPSGTQE 634
Cdd:pfam17823 343 TNLAVVTTTKAQAKEPSASPVPVLHTSM---IPEVEATSPTTQPS---PLLPTQGAAGPGILLAPEQ 403
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
468-706 |
3.66e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 44.10 E-value: 3.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 468 GGPHVATSVPLPVTWVLtaqgllPVPVPAVVSLPRPAGTPGPAGLLATLLPPLTETRAAQGPRAPALSSSWQPPANMNRE 547
Cdd:PRK12323 370 GGAGPATAAAAPVAQPA------PAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARG 443
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 548 PEPSCRTDTPAPPTHALSQSPAEADgsvafvpgeaqvareiPEPRTSSHADPPEAEPPWSGRLPAFGGVIPATEPRGTPG 627
Cdd:PRK12323 444 PGGAPAPAPAPAAAPAAAARPAAAG----------------PRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFA 507
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 628 SPSGTQEPRGPLGLEKLPLRQPG---PEKGALDLEKPPLPQPGPEKGALDLGLLSQEGEAATQQWLGGQRGVRVPLLGSR 704
Cdd:PRK12323 508 SPAPAQPDAAPAGWVAESIPDPAtadPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAAR 587
|
..
gi 578817794 705 LP 706
Cdd:PRK12323 588 LP 589
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
280-652 |
6.03e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 43.60 E-value: 6.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 280 PQASLLASTGPRPKPKTVSELLQEKRLQEARAREATRGPVVLpsqllVSSSVILQP---PLPHTP-HGRPAPGPTVLNVP 355
Cdd:pfam03154 189 PGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTL-----IQQTPTLHPqrlPSPHPPlQPMTQPPPPSQVSP 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 356 LSGPGAPAAAKPGTSGSWQEAGTSAKDKRLSTmQALPLAPVFSEAEGTAPAASQAPalgpgqisvscpesglGQSQApaa 435
Cdd:pfam03154 264 QPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPP-QPFPLTPQSSQSQVPPGPSPAAP----------------GQSQQ--- 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 436 srkqgLPEAPPFLPAAPSPTPLPVQPLSLTHIGGPHVATSVPLPVTWVLTAQG-LLPVPVPAVVSLPRPAGTPGPAGLLA 514
Cdd:pfam03154 324 -----RIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQShKHPPHLSGPSPFQMNSNLPPPPALKP 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 515 TLLPPLTETRAAQGPRAPALSSSWQPPANMNREPEPSCRTDTPA-----PPTHALSQSPAEAD-GSVAFVPGEAQVAREI 588
Cdd:pfam03154 399 LSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPpaashPPTSGLHQVPSQSPfPQHPFVPGGPPPITPP 478
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 589 PEPRTSSHADPPEAEPPWSGRlPAFGGVIPATEPRGTPG------SPSGTQEPRGPlgleKLPLRQPGPE 652
Cdd:pfam03154 479 SGPPTSTSSAMPGIQPPSSAS-VSSSGPVPAAVSCPLPPvqikeeALDEAEEPESP----PPPPRSPSPE 543
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
282-638 |
7.32e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.62 E-value: 7.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 282 ASLLASTGPRPKPKTVSELLQEKRLQEARAREATRGPVVLPSQLLVSSSVIlqPPLPHTPHGRPAPGPTVLNVPLSGPGA 361
Cdd:PHA03307 57 AGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPT--PPGPSSPDPPPPTPPPASPPPSPAPDL 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 362 PAAAKPGTSGSWQEAGTSAKDkrlstmqALPLAPVFSEAEGTAPAASQAPALGPGQISVSCPESGLGQSQAPAASRKQGL 441
Cdd:PHA03307 135 SEMLRPVGSPGPPPAASPPAA-------GASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPP 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 442 PEAPPFLPAAPSPTPLPVQPLSLTHIGGPHVATSVPLPVTwVLTAQGLLPVPVPAVVSLPRPAGTPGPAGLLATLLPPLT 521
Cdd:PHA03307 208 RRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGC-GWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPAS 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 522 ETRAAQGPRAPALSSSwqppanmnrepepSCRTDTPAPPTHALSQSPAEADGSVAFVPGEAQVAREIPEPRTSSHADPPE 601
Cdd:PHA03307 287 SSSSPRERSPSPSPSS-------------PGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSP 353
|
330 340 350
....*....|....*....|....*....|....*..
gi 578817794 602 AEPPwsgrlPAFGGVIPATEPRGTPGSPSGTQEPRGP 638
Cdd:PHA03307 354 SRPP-----PPADPSSPRKRPRPSRAPSSPAASAGRP 385
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
307-606 |
1.01e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 42.91 E-value: 1.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 307 QEARAREATRGPVVLPSQLLVSSSVILQPPLPHTPHGRPAPGPTVLNVPLSGPGAPAAAKPGTSGSWQEaGTSAKDKRLS 386
Cdd:PRK07003 372 VPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGD-DAADGDAPVP 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 387 TMQALPLAPVFSEAEGTA-PAASQAPALGPGqisvscpesglgqSQAPAASRKQGLPEAPPFLPAAPSPTPLPVQPLSLT 465
Cdd:PRK07003 451 AKANARASADSRCDERDAqPPADSGSASAPA-------------SDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAAS 517
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 466 HIGGPHVATSVPlpvtwvltaqGLLPVPVPAVVSLPRPAGTPGPAGLLATLLPPLTETRAAQGPRAPALSSSWQPPANMN 545
Cdd:PRK07003 518 REDAPAAAAPPA----------PEARPPTPAAAAPAARAGGAAAALDVLRNAGMRVSSDRGARAAAAAKPAAAPAAAPKP 587
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578817794 546 REPEPSCRTDTPAPPTHALSQSPAEAdgsvafvpgeaqvareipePRTSSHADPPEAEPPW 606
Cdd:PRK07003 588 AAPRVAVQVPTPRARAATGDAPPNGA-------------------ARAEQAAESRGAPPPW 629
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
342-560 |
1.04e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 42.67 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 342 HGRPAPGPTVLNVPLSGPGAPAAAKPGTSGSWQEAGTSAKDKRlstmqalplAPVFSEAEGTAPAASQAPALGPGQISVS 421
Cdd:PRK07764 590 PAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGA---------AAAPAEASAAPAPGVAAPEHHPKHVAVP 660
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 422 CPESGLGQSQAPAASRKQGLPEAPPFLPAAPSPTPLPVQPLSLTHIGGPHVATSVPLPVTWVLTAQGLLPVPVPAVVSLP 501
Cdd:PRK07764 661 DASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVP 740
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 578817794 502 RPaGTPGPAGLLATLLPPLTETRAAQGPRAPALSSSWQPPAnmnrEPEPSCRTDTPAPP 560
Cdd:PRK07764 741 LP-PEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPS----EEEEMAEDDAPSMD 794
|
|
| PksD |
COG3321 |
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ... |
196-723 |
2.42e-03 |
|
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 442550 [Multi-domain] Cd Length: 1386 Bit Score: 41.78 E-value: 2.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 196 TLFTQLFHIDTAGCLEVVRERKALPPRLP----QAGARDPPVHLLQASSSAQSTPGHLFPNVPAQEASKSASHKGSRRLA 271
Cdd:COG3321 839 QLWVAGVPVDWSALYPGRGRRRVPLPTYPfqreDAAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAA 918
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 272 SSRVERTLPQASLLASTGPRPKPKTVSELLQEKRLQEARAREATRGPVVLPSQLLVSSSVILQPPLPHTPHGRPAPGPTV 351
Cdd:COG3321 919 LALAAAALAALLALVALAAAAAALLALAAAAAAAAAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAA 998
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 352 LNVPLSGPGAPAAAKPGTSGSWQEAGTSAKDKRLSTMQALPLAPVFSEAEGTAPAASQAPALGPGQISVSCPESGLGQSQ 431
Cdd:COG3321 999 AAALALLAAAALLLAAAAAAAALLALAALLAAAAAALAAAAAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELA 1078
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 432 APAASRKQGLPEAPPFLPAAPSPTPLPVQPLSLTHIGGPHVATSVPLPVTWVLTAQGLLPVPVPAVVSLPRPAGTPGPAG 511
Cdd:COG3321 1079 LAAAALALAAALAAAALALALAALAAALLLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAA 1158
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 512 LLATLLPPLTETRAAQGPRAPALSSSWQPPANMNREPEPSCRTDTPAPPTHALSQSPAEADGSVAFVPGEAQVAREIPEP 591
Cdd:COG3321 1159 LAAALAAALLAAAALLLALALALAAALAAALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLAL 1238
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 592 RTSSHADPPEAE-PPWSGRLPAFGGVIPATEPRGTPGSPSGTQEPRGPLGLEKLPLRQPGPEKGALDLEKPPLPQPGPEK 670
Cdd:COG3321 1239 AAAAAAVAALAAaAAALLAALAALALLAAAAGLAALAAAAAAAAAALALAAAAAAAAAALAALLAAAAAAAAAAAAAAAA 1318
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 578817794 671 GALDLGLLSQEGEAATQQWLGGQRGVRVPLLGSRLPYQPPALCSLRALSGLLL 723
Cdd:COG3321 1319 AALAAALLAAALAALAAAVAAALALAAAAAAAAAAAAAAAAAAALAAAAGAAA 1371
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
334-666 |
3.32e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 41.29 E-value: 3.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 334 QPPLPHTPHGRPAPGPTvlnvPLSGPGAPAAAKPGTSGSWQEAGTSAKDKRLSTMQALPLAPVFSEAEGTAPAASQAPAL 413
Cdd:pfam03154 170 QPPVLQAQSGAASPPSP----PPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSP 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 414 GPgqisvscPESGLGQSQAPAASRKQGLPEAPPFLPAAPSPTPLPVQPLSLTHIGGPHvatsvPLPVTWVLTAQGLLPVP 493
Cdd:pfam03154 246 HP-------PLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQ-----PFPLTPQSSQSQVPPGP 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 494 VPAVvslprpagtPGPAGLLATLLPPLTETRAAQGPRAPALssswqPPANMNR-EPEPSCRTDTPAPPTHALSQSPAEAD 572
Cdd:pfam03154 314 SPAA---------PGQSQQRIHTPPSQSQLQSQQPPREQPL-----PPAPLSMpHIKPPPTTPIPQLPNPQSHKHPPHLS 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 573 GSVAFvpgeaQVAREIPEP------RTSSHADPPEAEPPWSGRLPAFGGV--IPATEPRGTPG---SPSGTQEPRgPLGL 641
Cdd:pfam03154 380 GPSPF-----QMNSNLPPPpalkplSSLSTHHPPSAHPPPLQLMPQSQQLppPPAQPPVLTQSqslPPPAASHPP-TSGL 453
|
330 340
....*....|....*....|....*
gi 578817794 642 EKLPLRQPGPEKGALDLEKPPLPQP 666
Cdd:pfam03154 454 HQVPSQSPFPQHPFVPGGPPPITPP 478
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
334-672 |
3.72e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.08 E-value: 3.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 334 QPPLPHTPHGRPAPGPTVLNVPLSGPGAPAAAKPGTSGSWQEAGT---SAKDKRLSTMQALPLAPVFSEaegtaPAASQA 410
Cdd:PHA03247 2414 QPDPPGPPDVRFVGSEEIEELPFVSPGGDVLAGLAADGDPFFARTilgAPFSLSLLLGELFPGAPVYRR-----PAEARF 2488
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 411 PALGPGqisvsCPESGLGQSQAPAASRKQGLPeAPPFLPAAPSPTPLPvqPLSLTHIGGPHVATSvplpvtwvlTAQGLL 490
Cdd:PHA03247 2489 PFAAGA-----APDPGGGGPPDPDAPPAPSRL-APAILPDEPVGEPVH--PRMLTWIRGLEELAS---------DDAGDP 2551
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 491 PVPVPAVVSLPRPAGTPGPAGLLATLLPPLTETRAAQgPRAPALSSSWQPPANmNREPEPSCRTDTPAPPTHALSQSPAE 570
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARR-PDAPPQSARPRAPVD-DRGDPRGPAPPSPLPPDTHAPDPPPP 2629
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817794 571 ADGSVAFVPGEAQVAREIPEPRTSSHADPPEAEPPWSGRLPAFGGVIPATEPRGTPGSPSGTQEPRGPLGLEKLPLRQPG 650
Cdd:PHA03247 2630 SPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPE 2709
|
330 340
....*....|....*....|..
gi 578817794 651 PEKGALDLEKPPLPQPGPEKGA 672
Cdd:PHA03247 2710 PAPHALVSATPLPPGPAAARQA 2731
|
|
| |
