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Conserved domains on  [gi|578817549|ref|XP_006717204|]
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epidermal growth factor-like protein 7 isoform X4 [Homo sapiens]

Protein Classification

EMI and EGF_CA domain-containing protein( domain architecture ID 10540335)

EMI and EGF_CA domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 28-94 6.25e-19

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


:

Pssm-ID: 462204  Cd Length: 69  Bit Score: 77.46  E-value: 6.25e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817549   28 RRVCAVR---AHGDPVSESFVQRVYQPFLTTCDGHRACSTYRTIYRTAYRRSPgLAPARPRYACCPGWKR 94
Cdd:pfam07546   1 RNVCAYKvvsCVVVTGTESYVQPVYKPYLTWCAGHRRCSTYRTTYRPAYRQVY-KTVTRLEWRCCPGWGG 69
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 110-135 5.97e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 5.97e-04
                         10        20
                 ....*....|....*....|....*....
gi 578817549 110 PCRNGGSCV-QPG--RCRCPAGWRGDTCQ 135
Cdd:cd00054   10 PCQNGGTCVnTVGsyRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 28-94 6.25e-19

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


Pssm-ID: 462204  Cd Length: 69  Bit Score: 77.46  E-value: 6.25e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817549   28 RRVCAVR---AHGDPVSESFVQRVYQPFLTTCDGHRACSTYRTIYRTAYRRSPgLAPARPRYACCPGWKR 94
Cdd:pfam07546   1 RNVCAYKvvsCVVVTGTESYVQPVYKPYLTWCAGHRRCSTYRTTYRPAYRQVY-KTVTRLEWRCCPGWGG 69
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 110-135 5.97e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 5.97e-04
                         10        20
                 ....*....|....*....|....*....
gi 578817549 110 PCRNGGSCV-QPG--RCRCPAGWRGDTCQ 135
Cdd:cd00054   10 PCQNGGTCVnTVGsyRCSCPPGYTGRNCE 38
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 111-134 1.88e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 34.63  E-value: 1.88e-03
                          10        20
                  ....*....|....*....|....*
gi 578817549  111 CRNGGSCVQP-GRCRCPAGWRGDTC 134
Cdd:pfam07974   2 CSGRGTCVNQcGKCVCDSGYQGATC 26
 
Name Accession Description Interval E-value
EMI pfam07546
EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final ...
 28-94 6.25e-19

EMI domain; The Pfam alignment is truncated at the C-terminus and does not include the final cysteine defined in Callebaut et al. This is to stop the family overlapping with other domains.


Pssm-ID: 462204  Cd Length: 69  Bit Score: 77.46  E-value: 6.25e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817549   28 RRVCAVR---AHGDPVSESFVQRVYQPFLTTCDGHRACSTYRTIYRTAYRRSPgLAPARPRYACCPGWKR 94
Cdd:pfam07546   1 RNVCAYKvvsCVVVTGTESYVQPVYKPYLTWCAGHRRCSTYRTTYRPAYRQVY-KTVTRLEWRCCPGWGG 69
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 110-135 5.97e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 5.97e-04
                         10        20
                 ....*....|....*....|....*....
gi 578817549 110 PCRNGGSCV-QPG--RCRCPAGWRGDTCQ 135
Cdd:cd00054   10 PCQNGGTCVnTVGsyRCSCPPGYTGRNCE 38
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 111-134 1.88e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 34.63  E-value: 1.88e-03
                          10        20
                  ....*....|....*....|....*
gi 578817549  111 CRNGGSCVQP-GRCRCPAGWRGDTC 134
Cdd:pfam07974   2 CSGRGTCVNQcGKCVCDSGYQGATC 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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