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Conserved domains on  [gi|578812944|ref|XP_006715617|]
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dynein light chain Tctex-type protein 2 isoform X2 [Homo sapiens]

Protein Classification

dynein light chain family protein( domain architecture ID 1750150)

dynein light chain family protein may act as an ATPase that generates force towards the minus end of microtubules, function as a non-catalytic accessory component of the cytoplasmic dynein complex, or play a functional role that has not yet been characterized

CATH:  3.30.740.10
Gene Ontology:  GO:0007017|GO:0030286
SCOP:  3000821

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DLC-like_SF super family cl41776
dynein light chain (DLC)-like domain superfamily; The superfamily corresponds to a class of ...
 43-136 6.67e-36

dynein light chain (DLC)-like domain superfamily; The superfamily corresponds to a class of proteins containing a dynein light chain (DLC)-like domain with anti-parallel beta-sheet packed against an alpha-helical hairpin. DLC-like domain-containing proteins includes cytoplasmic dynein light chain DYNLL1 and DYNLL2, axonemal dynein light chain 4 (DNAL4), tegumental-allergen-like proteins (TALs), dynein light chain Tctex-type DYNLT1 and DYNLT3, as well as Tctex1 domain-containing proteins (TCTEX1D). Both DYNLL1 and DYNLL2 are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. DNAL4 is a force generating protein of respiratory cilia. TALs may be involved in the transport of vesicles within the tegumental cytoplasm, probably within dynein motor complexes. DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex, which contains either DYNLT1 or DYNLT3, but not both. TCTEX1D family includes TCTEX1D1-4. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). TCTEX1D2 is required for proper retrograde ciliary transport. TCTEX1D3 may be an accessory component of axonemal dynein and cytoplasmic dynein 1. TCTEX1D4 is a novel protein phosphatase 1 (PPP1) interactor.


The actual alignment was detected with superfamily member cd21460:

Pssm-ID: 425407  Cd Length: 112  Bit Score: 119.36  E-value: 6.67e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812944  43 QILRERLRESIHNVQyVEPPFDDSIADidRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIASRWIWDIAWDSWVAAKHE 122
Cdd:cd21460   22 EILKEKLKDIKYDAD-RCRSLSLSLAA--DILAAVKELGFDRYKYVVRVFLGEKTGQSVKIASRAVWDTEKDNWVSATFE 98

                         90
                 ....*....|....
gi 578812944 123 AESYVALVLVFALY 136
Cdd:cd21460   99 NESLFAVALVFALY 112
 
Name Accession Description Interval E-value
DLC-like_TCTEX1D3 cd21460
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 3 (TCTEX1D3) ...
 43-136 6.67e-36

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 3 (TCTEX1D3) and similar proteins; Tctex1 domain-containing protein 3 (TCTEX1D3), also called T-complex testis-specific protein 3, or T-complex-associated testis-expressed protein 3 (Tcte-3), may be an accessory component of axonemal dynein and cytoplasmic dynein 1. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D3.


Pssm-ID: 412008  Cd Length: 112  Bit Score: 119.36  E-value: 6.67e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812944  43 QILRERLRESIHNVQyVEPPFDDSIADidRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIASRWIWDIAWDSWVAAKHE 122
Cdd:cd21460   22 EILKEKLKDIKYDAD-RCRSLSLSLAA--DILAAVKELGFDRYKYVVRVFLGEKTGQSVKIASRAVWDTEKDNWVSATFE 98

                         90
                 ....*....|....
gi 578812944 123 AESYVALVLVFALY 136
Cdd:cd21460   99 NESLFAVALVFALY 112
Tctex-1 pfam03645
Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to ...
 43-133 7.15e-22

Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit this interaction.


Pssm-ID: 461003  Cd Length: 96  Bit Score: 83.34  E-value: 7.15e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812944   43 QILRERLRESI-HNVQYVEPPFDDSIADI-DRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIASRWIWDIAWDSWVAAK 120
Cdd:pfam03645   4 EIIKEVLEEVLgGGETYDHEKVPQWTKEIsEEILDRLKELGFKRYKYIVNVTIGQKNGQGVHVASRCLWDPETDGYASYK 83

                          90
                  ....*....|...
gi 578812944  121 HEAESYVALVLVF 133
Cdd:pfam03645  84 FENKSLFAVVTVF 96
 
Name Accession Description Interval E-value
DLC-like_TCTEX1D3 cd21460
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 3 (TCTEX1D3) ...
 43-136 6.67e-36

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 3 (TCTEX1D3) and similar proteins; Tctex1 domain-containing protein 3 (TCTEX1D3), also called T-complex testis-specific protein 3, or T-complex-associated testis-expressed protein 3 (Tcte-3), may be an accessory component of axonemal dynein and cytoplasmic dynein 1. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D3.


Pssm-ID: 412008  Cd Length: 112  Bit Score: 119.36  E-value: 6.67e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812944  43 QILRERLRESIHNVQyVEPPFDDSIADidRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIASRWIWDIAWDSWVAAKHE 122
Cdd:cd21460   22 EILKEKLKDIKYDAD-RCRSLSLSLAA--DILAAVKELGFDRYKYVVRVFLGEKTGQSVKIASRAVWDTEKDNWVSATFE 98

                         90
                 ....*....|....
gi 578812944 123 AESYVALVLVFALY 136
Cdd:cd21460   99 NESLFAVALVFALY 112
Tctex-1 pfam03645
Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to ...
 43-133 7.15e-22

Tctex-1 family; Tctex-1 is a dynein light chain. It has been shown that Tctex-1 can bind to the cytoplasmic tail of rhodopsin. C-terminal rhodopsin mutations responsible for retinitis pigmentosa inhibit this interaction.


Pssm-ID: 461003  Cd Length: 96  Bit Score: 83.34  E-value: 7.15e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812944   43 QILRERLRESI-HNVQYVEPPFDDSIADI-DRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIASRWIWDIAWDSWVAAK 120
Cdd:pfam03645   4 EIIKEVLEEVLgGGETYDHEKVPQWTKEIsEEILDRLKELGFKRYKYIVNVTIGQKNGQGVHVASRCLWDPETDGYASYK 83

                          90
                  ....*....|...
gi 578812944  121 HEAESYVALVLVF 133
Cdd:pfam03645  84 FENKSLFAVVTVF 96
DLC-like_TCTEX1D cd21451
dynein light chain (DLC)-like domain found in the Tctex1 domain-containing protein (TCTEX1D) ...
 36-135 1.18e-19

dynein light chain (DLC)-like domain found in the Tctex1 domain-containing protein (TCTEX1D) family; The Tctex1 domain-containing protein (TCTEX1D) family includes TCTEX1D1-4. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). It can interact with ZMYND10 that stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms. TCTEX1D2 is required for proper retrograde ciliary transport. It associates with short-rib polydactyly syndrome proteins, such as Wdr34, Wdr60, and other dynein complex 1 and 2 subunits, and is required for ciliogenesis. TCTEX1D2 is a negative regulator of GLUT4 translocation and glucose uptake. TCTEX1D3, also called T-complex testis-specific protein 3, or T-complex-associated testis-expressed protein 3 (Tcte-3), may be an accessory component of axonemal dynein and cytoplasmic dynein 1. TCTEX1D4, also called protein N22.1, or Tctex-2-beta, is a novel protein phosphatase 1 (PPP1) interactor. It also interacts with ENG/endoglin, TGFBR2, and TGFBR3. The distribution of TCTEX1D4 in testis suggests its involvement in distinct functions, such as TGFbeta signaling at the blood-testis barrier and acrosome cap formation. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1Ds.


Pssm-ID: 411999  Cd Length: 101  Bit Score: 77.53  E-value: 1.18e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812944  36 FEKEAYTQILRERLRESIHNVQYVEPPFDDSIADI-DRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIASRWIWDIAWD 114
Cdd:cd21451    1 FNPEKVKKIIKEVLEERLENVTYDPEECAQLCKELsEEIKDRVKELGFDRYKIVVQVTIGEKKGQGVRVASRCLWDPETD 80

                         90       100
                 ....*....|....*....|.
gi 578812944 115 SWVAAKHEAESYVALVLVFAL 135
Cdd:cd21451   81 NFASATFENESLFAVATVFGV 101
DLC-like_TCTEX1D2 cd21459
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 2 (TCTEX1D2) ...
 43-137 9.47e-16

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 2 (TCTEX1D2) and similar proteins; Tctex1 domain-containing protein 2 (TCTEX1D2) is required for proper retrograde ciliary transport. It associates with short-rib polydactyly syndrome proteins, such as Wdr34, Wdr60, and other dynein complex 1 and 2 subunits, and is required for ciliogenesis. TCTEX1D2 is a negative regulator of GLUT4 translocation and glucose uptake. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D2.


Pssm-ID: 412007  Cd Length: 104  Bit Score: 67.89  E-value: 9.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812944  43 QILRERLRESIHNVQYVEPPFDDSIADI-DRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIASRWIWDIAWDSWVAAKH 121
Cdd:cd21459    9 EIIHEVLKEKLAGKTYDPEEAPQWTKEIaDEIKDKLKELGFPRYKIVVQVVIGEQRGQGVRVGSRCLWDADTDNYASEVF 88

                         90
                 ....*....|....*.
gi 578812944 122 EAESYVALVLVFALYY 137
Cdd:cd21459   89 INDSLFCVATVFGVYY 104
DLC-like_TCTEX1D4 cd21461
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 4 (TCTEX1D4) ...
 71-138 1.90e-10

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 4 (TCTEX1D4) and similar proteins; Tctex1 domain-containing protein 4 (TCTEX1D4), also called protein N22.1, or Tctex-2-beta, is a novel protein phosphatase 1 (PPP1) interactor. It also interacts with ENG/endoglin, TGFBR2 and TGFBR3. The distribution of TCTEX1D4 in testis suggests its involvement in distinct functions, such as TGFbeta signaling at the blood-testis barrier and acrosome cap formation. The model corresponds to the dynein light chain (DLC)-like domain of TCTEX1D4.


Pssm-ID: 412009  Cd Length: 114  Bit Score: 54.28  E-value: 1.90e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578812944  71 DRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIASRWIWDIAWDSWVAAKHEAESYVALVLVFALYYE 138
Cdd:cd21461   47 ELVRSKVKDLSPPRYKLVCQVVLGQCGNQGLRVASRCLWDPERDNFASASFQNASLFAVATVHGVYFE 114
DLC-like_TCTEX1D1 cd21458
dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 1 (TCTEX1D1) ...
 36-138 7.37e-10

dynein light chain (DLC)-like domain found in Tctex1 domain-containing protein 1 (TCTEX1D1) and similar proteins; Tctex1 domain-containing protein 1 (TCTEX1D1) is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). It can interact with ZMYND10 that stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms. The model corresponds to the (dynein light chain) DLC-like domain of TCTEX1D1.


Pssm-ID: 412006  Cd Length: 104  Bit Score: 52.68  E-value: 7.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812944  36 FEKEAYTQILRERLRESIHNVQYvEPPF----DDSIADIdrILLAVKEFGYHRYKFIIKVLFIQKTGQAINIASRWIWDI 111
Cdd:cd21458    1 FPVASVKNILKDVLESYLQEERY-EPELcrqmTKTISEV--IKARVKDLMLPRYKIIVLVHIGQLNDQGLRVGSRCLWDP 77

                         90       100
                 ....*....|....*....|....*..
gi 578812944 112 AWDSWVAAKHEAESYVALVLVFALYYE 138
Cdd:cd21458   78 ANDTFSSYEFRNSSLFAVATVYGVYFE 104
DLC-like_SF cd21449
dynein light chain (DLC)-like domain superfamily; The superfamily corresponds to a class of ...
 43-134 2.28e-08

dynein light chain (DLC)-like domain superfamily; The superfamily corresponds to a class of proteins containing a dynein light chain (DLC)-like domain with anti-parallel beta-sheet packed against an alpha-helical hairpin. DLC-like domain-containing proteins includes cytoplasmic dynein light chain DYNLL1 and DYNLL2, axonemal dynein light chain 4 (DNAL4), tegumental-allergen-like proteins (TALs), dynein light chain Tctex-type DYNLT1 and DYNLT3, as well as Tctex1 domain-containing proteins (TCTEX1D). Both DYNLL1 and DYNLL2 are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. DNAL4 is a force generating protein of respiratory cilia. TALs may be involved in the transport of vesicles within the tegumental cytoplasm, probably within dynein motor complexes. DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex, which contains either DYNLT1 or DYNLT3, but not both. TCTEX1D family includes TCTEX1D1-4. TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy (DMD). TCTEX1D2 is required for proper retrograde ciliary transport. TCTEX1D3 may be an accessory component of axonemal dynein and cytoplasmic dynein 1. TCTEX1D4 is a novel protein phosphatase 1 (PPP1) interactor.


Pssm-ID: 411997  Cd Length: 96  Bit Score: 48.49  E-value: 2.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812944  43 QILRERLrESIHNVQYVEPPFDDSIAD--IDRILLAVKEFGYHRYKFIIKVLFIQKTGQAINIASRWIWDIAWDSWVAAK 120
Cdd:cd21449    4 EIIKEVL-ESILDDKEYDPLKLKEIAKkiSEEIKEKLKELSPSRYKYIVHVTISENNGQGIRADSGCLWDPDTDGFVSEV 82

                         90
                 ....*....|....
gi 578812944 121 HEAESYVALVLVFA 134
Cdd:cd21449   83 YENDNIICTVTVFG 96
DLC-like_DYNLT1_DYNLT3 cd21455
dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) ...
 39-135 4.10e-08

dynein light chain (DLC)-like domain found in the dynein light chain Tctex-type 1 (DYNLT1) family; The dynein light chain Tctex-type 1 (DYNLT1) family includes two isoforms, DYNLT1 and DYNLT3, which contribute to the differential regulation of dynein cargo binding. They are non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. The dynein complex contains either DYNLT1 or DYNLT3, but not both. The model corresponds to the dynein light chain (DLC)-like domain of DYNLT1 and DYNLT3.


Pssm-ID: 412003  Cd Length: 97  Bit Score: 47.96  E-value: 4.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812944  39 EAYTQILRERLRESIHNVQYVEPPFDDSIADI-DRILLAVKEFGyHRYKFIIKVLFIQKTGQAINIASRWIWDIAWDSWV 117
Cdd:cd21455    1 EEVESIVKEAIEAVLGDKTYSHSKVNQWSNSIvEEILKRLAKLN-KPFKYIVTCVIMQKTGAGLHTASSCYWDPTTDGSV 79

                         90
                 ....*....|....*...
gi 578812944 118 AAKHEAESYVALVLVFAL 135
Cdd:cd21455   80 TVRWENKTMYCIVTVFGL 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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