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Conserved domains on  [gi|578812931|ref|XP_006715613|]
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PR domain zinc finger protein 1 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 95-222 7.04e-92

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


:

Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 283.83  E-value: 7.04e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931  95 ASLPRNLLFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEIYTNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMR 174
Cdd:cd19187    1 ASLPRNLTLKYSSVGREVLGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGANRKYFWRIYSNGEFYHYIDGFDPSKSNWMR 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 578812931 175 YVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERL 222
Cdd:cd19187   81 YVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFARRL 128
zf-H2C2_2 pfam13465
Zinc-finger double domain;
616-641 3.93e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 3.93e-06
                          10        20
                  ....*....|....*....|....*.
gi 578812931  616 NLKTHLRLHSGEKPYQCKVCPAKFTQ 641
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
644-669 2.39e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.39e-04
                          10        20
                  ....*....|....*....|....*.
gi 578812931  644 HLKLHKRLHTRERPHKCSQCHKNYIH 669
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 95-222 7.04e-92

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 283.83  E-value: 7.04e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931  95 ASLPRNLLFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEIYTNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMR 174
Cdd:cd19187    1 ASLPRNLTLKYSSVGREVLGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGANRKYFWRIYSNGEFYHYIDGFDPSKSNWMR 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 578812931 175 YVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERL 222
Cdd:cd19187   81 YVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFARRL 128
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 114-220 3.55e-25

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 101.26  E-value: 3.55e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931   114 GVMSKEYIPKGTRFGPLIGEIYTNDTVPK--------NANRKYFWRIYSrgelHHFIDGFNeeKSNWMRYVNPAHSPREQ 185
Cdd:smart00317  14 GVRATEDIPKGEFIGEYVGEIITSEEAEErpkaydtdGAKAFYLFDIDS----DLCIDARR--KGNLARFINHSCEPNCE 87

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 578812931   186 NLAACQNGMN-IYFYTIKPIPANQELLVWYCRDFAE 220
Cdd:smart00317  88 LLFVEVNGDDrIVIFALRDIKPGEELTIDYGSDYAN 123
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 114-214 3.29e-13

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 66.78  E-value: 3.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931  114 GVMSKEYIPKGTRFGPLIGE-IYTNDTVPKNANRKY------FWRIYS---RGELHHFIDGFNEEKSNWMRYVNpaHSpR 183
Cdd:pfam00856   3 GLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYdklelrLWGPYLftlDEDSEYCIDARALYYGNWARFIN--HS-C 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 578812931  184 EQNLAA----CQNGMNIYFYTIKPIPANQELLVWY 214
Cdd:pfam00856  80 DPNCEVrvvyVNGGPRIVIFALRDIKPGEELTIDY 114
zf-H2C2_2 pfam13465
Zinc-finger double domain;
616-641 3.93e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 3.93e-06
                          10        20
                  ....*....|....*....|....*.
gi 578812931  616 NLKTHLRLHSGEKPYQCKVCPAKFTQ 641
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
644-669 2.39e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.39e-04
                          10        20
                  ....*....|....*....|....*.
gi 578812931  644 HLKLHKRLHTRERPHKCSQCHKNYIH 669
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 95-222 7.04e-92

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 283.83  E-value: 7.04e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931  95 ASLPRNLLFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEIYTNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMR 174
Cdd:cd19187    1 ASLPRNLTLKYSSVGREVLGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGANRKYFWRIYSNGEFYHYIDGFDPSKSNWMR 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 578812931 175 YVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERL 222
Cdd:cd19187   81 YVNPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWYCREFARRL 128
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 114-222 4.54e-34

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 126.58  E-value: 4.54e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931 114 GVMSKEYIPKGTRFGPLIGEIYTNDtvpKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQNG 193
Cdd:cd19193   21 GVWAEAPIPKGMVFGPYEGEIVEDE---EAADSGYSWQIYKGGKLSHYIDAKDESKSNWMRYVNCARNEEEQNLVAFQYR 97

                         90       100
                 ....*....|....*....|....*....
gi 578812931 194 MNIYFYTIKPIPANQELLVWYCRDFAERL 222
Cdd:cd19193   98 GKIYYRTCKDIAPGTELLVWYGDEYAKEL 126
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 92-222 1.44e-31

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 119.88  E-value: 1.44e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931  92 QAEASLPRNLLFKYATNSEEViGVMSKEYIPKGTRFGPLIGEIYTNDTVP--KNANRKYFWRIYSRGELHHFIDGFNEEK 169
Cdd:cd19189    1 RARLSLPRQLYLRQSETGAEV-GVWTKETIPVRTCFGPLIGQQSHSAEVAdwTDKAAPHIWKIYHNDVLEFCIITTDENE 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 578812931 170 SNWMRYVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERL 222
Cdd:cd19189   80 CNWMMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYYSRDYARQL 132
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 97-214 5.79e-31

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 116.14  E-value: 5.79e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931  97 LPRNLLFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEIytndtvpknanrkyfwriysrgelhhfidgfneeksNWMRYV 176
Cdd:cd10534    1 LPAGLELVLSSIPEGGLGVFARRTIPAGTRFGPLEGVV------------------------------------NWMRFV 44

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 578812931 177 NPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWY 214
Cdd:cd10534   45 RPARNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVWY 82
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 93-222 8.07e-30

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 114.37  E-value: 8.07e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931  93 AEASLPRNL-LFKYATNSeevIGVMSKEYIPKGTRFGPLIGEIYTNDTVPKNanrkYFWRIYSRGELHH--FIDGFNEEK 169
Cdd:cd19194    2 ARASLPLILqIFRFGETL---GGVFAKRRIPKRTQFGPLEGPLVKKSELKDN----KIHPLELEEDDGEdlYFDLSDENK 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 578812931 170 SNWMRYVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERL 222
Cdd:cd19194   75 CNWMMFVRPAQNHLEQNLVAYQYGQEIYFTTIKNIEPKQELKVWYAASYAEFL 127
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 113-225 2.04e-29

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 113.61  E-value: 2.04e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931 113 IGVMSKEYIPKGTRFGPLIGEIYTNDTVPKNANRKYFWRIY-SRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQ 191
Cdd:cd19196   17 LGVFSKTWIKEGTEMGPYTGRIVSPEDVDPCKNNNLMWEVFnEDGTVSHFIDASQENHRSWMTFVNCARNEQEQNLEVVQ 96

                         90       100       110
                 ....*....|....*....|....*....|....
gi 578812931 192 NGMNIYFYTIKPIPANQELLVWYCRDFAERLHYP 225
Cdd:cd19196   97 IGESIYYRAIKDIPPDQELLVWYGNSYNTFLGIP 130
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 114-214 6.00e-29

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 112.11  E-value: 6.00e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931 114 GVMSKEYIPKGTRFGPLIGEIYTNDTVPKNANRKYFWRIYSRGELHHFIDGfNEEKSNWMRYVNPAHSPREQNLAACQNG 193
Cdd:cd19198   21 GVFCKKTIPKGTRFGPFRGRVVNTSEIKTYDDNSFMWEIFEDGKLSHFIDG-RGSTGNWMSYVNCARYAEEQNLIAIQCQ 99

                         90       100
                 ....*....|....*....|.
gi 578812931 194 MNIYFYTIKPIPANQELLVWY 214
Cdd:cd19198  100 GQIFYESCKEILQGQELLVWY 120
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 97-214 1.08e-26

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 105.64  E-value: 1.08e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931  97 LPRNLLFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEIYTNDTVPKNA-NRKYFWRIYSR-GELHHFIDGFNEEKSNWMR 174
Cdd:cd19191    1 LPDEVCLCTSSIPGLGYGICAAQRIPQGTWIGPFEGVLVSPEKQIGAVrNTQHLWEIYDQeGTLQHFIDGGDPSKSSWMR 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 578812931 175 YVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWY 214
Cdd:cd19191   81 YIRCARHCGEQNLTVVQYRGCIFYRACRDIPRGTELLVWY 120
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 114-220 3.55e-25

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 101.26  E-value: 3.55e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931   114 GVMSKEYIPKGTRFGPLIGEIYTNDTVPK--------NANRKYFWRIYSrgelHHFIDGFNeeKSNWMRYVNPAHSPREQ 185
Cdd:smart00317  14 GVRATEDIPKGEFIGEYVGEIITSEEAEErpkaydtdGAKAFYLFDIDS----DLCIDARR--KGNLARFINHSCEPNCE 87

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 578812931   186 NLAACQNGMN-IYFYTIKPIPANQELLVWYCRDFAE 220
Cdd:smart00317  88 LLFVEVNGDDrIVIFALRDIKPGEELTIDYGSDYAN 123
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 97-214 1.62e-24

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 99.05  E-value: 1.62e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931  97 LPRNLLFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEIYTNDTVPKNAnrkYFWRIYSRGELHHFIDGFNEEKSNWMRYV 176
Cdd:cd19188    4 LPEELELKPSAVDKTRIGVWAKKSIPKGRKFGPFVGEKKKRSQVKNNV---YMWEIYGPKRGWMCVDASDPTKGNWLRYV 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 578812931 177 NPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWY 214
Cdd:cd19188   81 NWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWY 118
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 119-223 3.35e-21

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 89.92  E-value: 3.35e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931 119 EYIPKGTRFGPLIGEIYTNDtvpkNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQNGMNIYF 198
Cdd:cd19195   26 EVIPKGHIFGPYEGQICTQD----KSSGFFSWLIVDKNNRYKSIDGSDETKANWMRYVVISREEREQNLLAFQHSEQIYF 101

                         90       100
                 ....*....|....*....|....*
gi 578812931 199 YTIKPIPANQELLVWYCRDFAERLH 223
Cdd:cd19195  102 RACRDIRPGEKLRVWYSEDYMKRLH 126
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 92-222 2.59e-20

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 87.47  E-value: 2.59e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931  92 QAEASLPRNLLFKYATNSEEviGVMSKEYIPKGTRFGPLIGEIYTndTVPKNAnRKYFWRIYSRGELHHFiDGFNEEKSN 171
Cdd:cd19199    2 RARSSLPDNLEIRQLEDGSE--GVFALVPLVKRTQFGPFEAKRVA--RLDGFA-VFPLKVFEKDGSVVYL-DTSNEDDCN 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 578812931 172 WMRYVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERL 222
Cdd:cd19199   76 WMMFVRPATDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRVWYAAFYAKKM 126
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 96-218 1.45e-17

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 79.31  E-value: 1.45e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931  96 SLPRNLLFKYATNSEEV-IGVMSKEYIPKGTRFGPLIGEIytndtVPKNANRKYFWRIYSRGELHH--FIDGFnEEKSNW 172
Cdd:cd19201    2 SLPGELELRKPSQDAGRsGGVWAKQPLPEGTRFGPYPGKL-----VKEPLDPSYEWKVEAQGSKGGegLLLLT-EDSGTW 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 578812931 173 MRYVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDF 218
Cdd:cd19201   76 LKLVRSADDEDEANLILYFKGGQIWCEVTKDIPPGEELILVLREPL 121
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 104-214 7.88e-17

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 77.33  E-value: 7.88e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931 104 KYATNSEEV---IGVMSKEYIPKGTRFGPLIGEIYTNDTVPKNANRKYFWRIY-SRGELHHFIDGFNEEKSNWMRYVNPA 179
Cdd:cd19190    8 RFSLKSSKVqdgMGLYTARRVKKGEKFGPFAGEKRMPNELDESMDPRLMWEVRgSKGEVLYILDASNPRHSNWLRFVHEA 87

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 578812931 180 HSPREQNLAACQNGMNIYFYTIKPIPANQELLVWY 214
Cdd:cd19190   88 PSQEQKNLAAIQEGENIFYLAVDDIETDTELLIGY 122
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 121-222 9.70e-15

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 71.69  E-value: 9.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931 121 IPKGTRFGPLIGEIYTNDTVPKNANRKYFWRI-YSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAA-CQNGMNIYF 198
Cdd:cd19192   28 IPAGTIFGPCVLSFTLGYDIADIALKTTDKRVvPYIFRVDTGACNGSSEPSDWLRLVQPARDRHEQNLEAfRKNEGQVYF 107

                         90       100
                 ....*....|....*....|....
gi 578812931 199 YTIKPIPANQELLVWYCRDFAERL 222
Cdd:cd19192  108 RTLRRIRKGEELLVWYSDELAELL 131
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 114-214 3.29e-13

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 66.78  E-value: 3.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931  114 GVMSKEYIPKGTRFGPLIGE-IYTNDTVPKNANRKY------FWRIYS---RGELHHFIDGFNEEKSNWMRYVNpaHSpR 183
Cdd:pfam00856   3 GLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYdklelrLWGPYLftlDEDSEYCIDARALYYGNWARFIN--HS-C 79

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 578812931  184 EQNLAA----CQNGMNIYFYTIKPIPANQELLVWY 214
Cdd:pfam00856  80 DPNCEVrvvyVNGGPRIVIFALRDIKPGEELTIDY 114
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 113-212 6.74e-13

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 66.24  E-value: 6.74e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931 113 IGVMSKEYIPKGTRFGPLIGeiytndtVPKNA--NRKYFWRIYSR-GELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAA 189
Cdd:cd19200   26 LGVWTKVRIEVGEKFGPFVG-------VQRSSvkDPTYAWEIVDEfGKVKFWIDASEPGTGNWMKYIRSAPSCEQQNLMA 98

                         90       100
                 ....*....|....*....|...
gi 578812931 190 CQNGMNIYFYTIKPIPANQELLV 212
Cdd:cd19200   99 CQIDEQIYYKVVRDIQPGEELLL 121
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 121-214 6.17e-11

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 59.83  E-value: 6.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931 121 IPKGTRFGPLIGeiytNDTVPKN-ANRKYFWRI--YSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQN--GMN 195
Cdd:cd19197    1 IPAGLRLGPVPG----IFKLGKYlSDRKEPGNKkkVRRVRGDYLVDESGSPATEWIGLVRAARNNQEQNLEAIADlpGGQ 76

                         90
                 ....*....|....*....
gi 578812931 196 IYFYTIKPIPANQELLVWY 214
Cdd:cd19197   77 IFYRALRDIQPGEELTVWY 95
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 114-214 1.49e-09

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 56.58  E-value: 1.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931 114 GVMSKEYIPKGTRFGPLIGEIYTNDTVPKNANRKYFWR-IYSRGELHHFIDGFneEKSNWMRYVNPAHSPreqNLAA--- 189
Cdd:cd10522   16 GLFAAETIAKGEFVGEYTGEVLDRWEEDRDSVYHYDPLyPFDLNGDILVIDAG--KKGNLTRFINHSDQP---NLELivr 90

                         90       100
                 ....*....|....*....|....*.
gi 578812931 190 CQNGMN-IYFYTIKPIPANQELLVWY 214
Cdd:cd10522   91 TLKGEQhIGFVAIRDIKPGEELFISY 116
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 96-213 1.56e-09

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 56.27  E-value: 1.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931  96 SLPRNLLFKYATNSEEVIGVMSKE-YIPKGTRFGPLIGE--IYTNDTVPKNANRKYFWRIYSRgelhhfidgFNEEKSNW 172
Cdd:cd10520    4 SLPPGLALGPSLAQEERLGVWCVGdALQKGTFLGPLEEEleSHDLTEGGSPRQEESGQSGDVL---------ACEQSSKW 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 578812931 173 MRYVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVW 213
Cdd:cd10520   75 MRFACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLLW 115
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 113-213 1.67e-09

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 57.58  E-value: 1.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931 113 IGVMSKEYIPKGTRFGPLIG-------------EIYTNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPA 179
Cdd:cd19213   36 LGVWAKRKIEAGERFGPYTGvqrstlkdtnfgwEQILNDVEVSSQEGCITKIVDDLGNEKFCVDAGQAGAGSWLKYIRVA 115

                         90       100       110
                 ....*....|....*....|....*....|....
gi 578812931 180 HSPREQNLAACQNGMNIYFYTIKPIPANQELLVW 213
Cdd:cd19213  116 CSCDEQNLTACQINEQIYYKVIKDIEPGEELLVY 149
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 113-213 2.35e-07

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 51.09  E-value: 2.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812931 113 IGVMSKEYIPKGTRFGPLIGEIYTNDTVPKnanrkYFWRIYSR-GELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQ 191
Cdd:cd19214   46 LGIWTKRKIEVGEKFGPYVGEQRSNLKDPS-----YGWEVLDEfGNVKFCIDASQPDVGSWLKYIRFAGCYDQHNLVACQ 120

                         90       100
                 ....*....|....*....|..
gi 578812931 192 NGMNIYFYTIKPIPANQELLVW 213
Cdd:cd19214  121 INDQIFYRAVADIDPGEELLLF 142
zf-H2C2_2 pfam13465
Zinc-finger double domain;
616-641 3.93e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.90  E-value: 3.93e-06
                          10        20
                  ....*....|....*....|....*.
gi 578812931  616 NLKTHLRLHSGEKPYQCKVCPAKFTQ 641
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
644-669 2.39e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.39e-04
                          10        20
                  ....*....|....*....|....*.
gi 578812931  644 HLKLHKRLHTRERPHKCSQCHKNYIH 669
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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