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Conserved domains on  [gi|578812719|ref|XP_006715533|]
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interferon gamma receptor 1 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Interfer-bind super family cl46366
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 151-307 4.04e-41

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


The actual alignment was detected with superfamily member pfam07140:

Pssm-ID: 480706  Cd Length: 133  Bit Score: 143.39  E-value: 4.04e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812719  151 YDPETTC-YIRVYNVYVRMNGSEIqYKILTQKEDDCDEIQCQLAIPVSSlnsQYCVSAEGVLHVWGVTTEKSKEVCITIF 229
Cdd:pfam07140   1 YGNGTTCdYTFGYTVYFLFNDSKE-ILEYSVDDRYCDEVQCRFNIESQE---NVCVSVVGVYGNWYVRTEASKDVCVPEL 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578812719  230 NSSikgslwipvvaalllflvlslVFICFYIKKINPLKEKSIILPKSLISVVRSATLETKPESKYvSLITSYQPFSLE 307
Cdd:pfam07140  77 VPR---------------------PVDPYYIKKRNDLKRVKIRLPNSLESVVKSATSETKPESLY-SLITSMFPRLLE 132
Tissue_fac super family cl47630
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 13-103 2.09e-18

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


The actual alignment was detected with superfamily member pfam01108:

Pssm-ID: 460067  Cd Length: 107  Bit Score: 80.51  E-value: 2.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812719   13 FQFKYGVPTPTNVTIESYNMNPIVYWEY-QIMPQVPVFTVEVKNYGVKNSEWIDACINISHHYCNISDHVGDPSNSLWVR 91
Cdd:pfam01108  16 AAGGPSLPAPQNVTFQSTNFKNILTWEPgPNSPPDVVYTVQYKIYGSGDWKNVPNCTNITRTECDLTDETSDLTETYYAR 95

                          90
                  ....*....|..
gi 578812719   92 VKARVGQKESAY 103
Cdd:pfam01108  96 VRAVSGGGTSSW 107
 
Name Accession Description Interval E-value
IFNGR1 pfam07140
Interferon gamma receptor (IFNGR1); This family consists of several eukaryotic and viral ...
 151-307 4.04e-41

Interferon gamma receptor (IFNGR1); This family consists of several eukaryotic and viral interferon gamma receptor proteins. Molecular interactions among cytokines and cytokine receptors in eukaryotes form the basis of many cell-signaling pathways relevant to immune function. Human interferon-gamma (IFN-gamma) signals through a multimeric receptor complex consisting of two different but structurally related transmembrane chains: the high-affinity receptor-binding subunit (IFN-gammaRalpha) and a species specific accessory factor (AF-1 or IFN-gammaRbeta). The vaccinia viral interferon gamma receptor has been shown to be secreted from infected cells during early infection. The structure has been halved such that the N-terminus of this family is now represented by Tissue_fac pfam01108.


Pssm-ID: 284538  Cd Length: 133  Bit Score: 143.39  E-value: 4.04e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812719  151 YDPETTC-YIRVYNVYVRMNGSEIqYKILTQKEDDCDEIQCQLAIPVSSlnsQYCVSAEGVLHVWGVTTEKSKEVCITIF 229
Cdd:pfam07140   1 YGNGTTCdYTFGYTVYFLFNDSKE-ILEYSVDDRYCDEVQCRFNIESQE---NVCVSVVGVYGNWYVRTEASKDVCVPEL 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578812719  230 NSSikgslwipvvaalllflvlslVFICFYIKKINPLKEKSIILPKSLISVVRSATLETKPESKYvSLITSYQPFSLE 307
Cdd:pfam07140  77 VPR---------------------PVDPYYIKKRNDLKRVKIRLPNSLESVVKSATSETKPESLY-SLITSMFPRLLE 132
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 13-103 2.09e-18

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 80.51  E-value: 2.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812719   13 FQFKYGVPTPTNVTIESYNMNPIVYWEY-QIMPQVPVFTVEVKNYGVKNSEWIDACINISHHYCNISDHVGDPSNSLWVR 91
Cdd:pfam01108  16 AAGGPSLPAPQNVTFQSTNFKNILTWEPgPNSPPDVVYTVQYKIYGSGDWKNVPNCTNITRTECDLTDETSDLTETYYAR 95

                          90
                  ....*....|..
gi 578812719   92 VKARVGQKESAY 103
Cdd:pfam01108  96 VRAVSGGGTSSW 107
 
Name Accession Description Interval E-value
IFNGR1 pfam07140
Interferon gamma receptor (IFNGR1); This family consists of several eukaryotic and viral ...
 151-307 4.04e-41

Interferon gamma receptor (IFNGR1); This family consists of several eukaryotic and viral interferon gamma receptor proteins. Molecular interactions among cytokines and cytokine receptors in eukaryotes form the basis of many cell-signaling pathways relevant to immune function. Human interferon-gamma (IFN-gamma) signals through a multimeric receptor complex consisting of two different but structurally related transmembrane chains: the high-affinity receptor-binding subunit (IFN-gammaRalpha) and a species specific accessory factor (AF-1 or IFN-gammaRbeta). The vaccinia viral interferon gamma receptor has been shown to be secreted from infected cells during early infection. The structure has been halved such that the N-terminus of this family is now represented by Tissue_fac pfam01108.


Pssm-ID: 284538  Cd Length: 133  Bit Score: 143.39  E-value: 4.04e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812719  151 YDPETTC-YIRVYNVYVRMNGSEIqYKILTQKEDDCDEIQCQLAIPVSSlnsQYCVSAEGVLHVWGVTTEKSKEVCITIF 229
Cdd:pfam07140   1 YGNGTTCdYTFGYTVYFLFNDSKE-ILEYSVDDRYCDEVQCRFNIESQE---NVCVSVVGVYGNWYVRTEASKDVCVPEL 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578812719  230 NSSikgslwipvvaalllflvlslVFICFYIKKINPLKEKSIILPKSLISVVRSATLETKPESKYvSLITSYQPFSLE 307
Cdd:pfam07140  77 VPR---------------------PVDPYYIKKRNDLKRVKIRLPNSLESVVKSATSETKPESLY-SLITSMFPRLLE 132
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 13-103 2.09e-18

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 80.51  E-value: 2.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578812719   13 FQFKYGVPTPTNVTIESYNMNPIVYWEY-QIMPQVPVFTVEVKNYGVKNSEWIDACINISHHYCNISDHVGDPSNSLWVR 91
Cdd:pfam01108  16 AAGGPSLPAPQNVTFQSTNFKNILTWEPgPNSPPDVVYTVQYKIYGSGDWKNVPNCTNITRTECDLTDETSDLTETYYAR 95

                          90
                  ....*....|..
gi 578812719   92 VKARVGQKESAY 103
Cdd:pfam01108  96 VRAVSGGGTSSW 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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