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Conserved domains on  [gi|578810013|ref|XP_006714570|]
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semaphorin-5A isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sema_5A cd11263
The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A); Originally, mouse ...
 50-485 0e+00

The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A); Originally, mouse Sema5A was identified as a protein that induces inhibitory responses during optic nerve development. Recent studies show that Sema5A controls innate immunity in mice. It also has been identified as a candidate gene for causing idiopathic autism in humans. Plexin B3 functions as a binding partner and receptor for Sema5A. Furthermore, Sema5A is also implicated in cancer. The role of the Drosophila Sema5A ortholog, Dsema-5C, in tumorigenicity and metastasis has been reported. Sema5A is highly expressed in human pancreatic cancer cells and is associated with tumor growth, invasion and metastasis. Sema5A belongs to class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


:

Pssm-ID: 200524 [Multi-domain]  Cd Length: 436  Bit Score: 977.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   50 FRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLF 129
Cdd:cd11263     1 FRAENAVDFSQLTFDPGQKELIVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  130 TCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQY 209
Cdd:cd11263    81 TCGTNAFTPICTNRTLNNLTEIHDQISGMARCPYSPQHNSTALLTSSGELYAATAMDFPGRDPAIYRSLGILPPLRTAQY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  210 NSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYN 289
Cdd:cd11263   161 NSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEIPFYYN 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  290 ELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGTVDQGLYVNLT 369
Cdd:cd11263   241 ELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAISQAFNGPFKYQENSRSAWLPYPNPNPNFQCGTMDQGLYVNLT 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  370 ERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTSSSCLLEEIE 449
Cdd:cd11263   321 ERNLQDAQKFILMHEVVQPVTPVPYFMEDNSRFSHVAVDVVQGKDMLFHIIYLATDYGTIKKVLAPLNQSSSSCLLEEIE 400

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 578810013  450 LFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLK 485
Cdd:cd11263   401 LFPKRQREPIRSLQILHSQSVLFVGLQEHVIKIPLK 436
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 844-896 2.61e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 76.47  E-value: 2.61e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 578810013    844 WSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPCP 896
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 598-651 7.78e-16

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 72.62  E-value: 7.78e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 578810013    598 WTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHlLCP 651
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQ-PCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 787-839 1.85e-15

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 71.46  E-value: 1.85e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 578810013    787 WSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQECNILPCP 839
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 656-702 1.13e-11

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 60.68  E-value: 1.13e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 578810013    656 WTGWGPWERCTAQCGGGIQARRRICENGP------DCAGCNVEYQSCNTNPCP 702
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPpqngggPCTGEDVETRACNEQPCP 53
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 486-533 2.53e-08

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 51.17  E-value: 2.53e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 578810013   486 RCQFYRTRSTCIGAQDPYCGWDVVMKKCTS----LEESLSMTQWEQSISACP 533
Cdd:pfam01437    1 RCSQYTSCSSCLAARDPYCGWCSSEGRCVRrsacGAPEGNCEEWEQASSKCP 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 544-595 7.15e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 49.89  E-value: 7.15e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 578810013    544 GVWSPWTPCTHTDGSAVgscLCRTRSCDSPAPQCGGWQCEGPGMEIANCSRN 595
Cdd:smart00209    2 SEWSEWSPCSVTCGGGV---QTRTRSCCSPPPQNGGGPCTGEDVETRACNEQ 50
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 899-940 8.38e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 46.81  E-value: 8.38e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 578810013    899 WSEWSDWSECEAS---GVQVRARQCIL--LFPMGSQCSGNTTESRPC 940
Cdd:smart00209    1 WSEWSEWSPCSVTcggGVQTRTRSCCSppPQNGGGPCTGEDVETRAC 47
 
Name Accession Description Interval E-value
Sema_5A cd11263
The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A); Originally, mouse ...
 50-485 0e+00

The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A); Originally, mouse Sema5A was identified as a protein that induces inhibitory responses during optic nerve development. Recent studies show that Sema5A controls innate immunity in mice. It also has been identified as a candidate gene for causing idiopathic autism in humans. Plexin B3 functions as a binding partner and receptor for Sema5A. Furthermore, Sema5A is also implicated in cancer. The role of the Drosophila Sema5A ortholog, Dsema-5C, in tumorigenicity and metastasis has been reported. Sema5A is highly expressed in human pancreatic cancer cells and is associated with tumor growth, invasion and metastasis. Sema5A belongs to class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200524 [Multi-domain]  Cd Length: 436  Bit Score: 977.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   50 FRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLF 129
Cdd:cd11263     1 FRAENAVDFSQLTFDPGQKELIVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  130 TCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQY 209
Cdd:cd11263    81 TCGTNAFTPICTNRTLNNLTEIHDQISGMARCPYSPQHNSTALLTSSGELYAATAMDFPGRDPAIYRSLGILPPLRTAQY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  210 NSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYN 289
Cdd:cd11263   161 NSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEIPFYYN 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  290 ELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGTVDQGLYVNLT 369
Cdd:cd11263   241 ELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAISQAFNGPFKYQENSRSAWLPYPNPNPNFQCGTMDQGLYVNLT 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  370 ERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTSSSCLLEEIE 449
Cdd:cd11263   321 ERNLQDAQKFILMHEVVQPVTPVPYFMEDNSRFSHVAVDVVQGKDMLFHIIYLATDYGTIKKVLAPLNQSSSSCLLEEIE 400

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 578810013  450 LFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLK 485
Cdd:cd11263   401 LFPKRQREPIRSLQILHSQSVLFVGLQEHVIKIPLK 436
Sema smart00630
semaphorin domain;
58-460 4.26e-129

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 397.89  E-value: 4.26e-129
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013     58 FSQLTFDPGQKELVVGARNYLFRLQLEDLSLI-QAVEWECDEATKKACYSKGKSK-EECQNYIRVLL-VGGDRLFTCGTN 134
Cdd:smart00630    1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAeLKTGPVLSSPDCEECVSKGKDPpTDCVNYIRLLLdYNEDRLLVCGTN 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013    135 AFTPVCTNRSLsnlteihdqisgmarcpyspqhnstalltagGELYAATAMDFPGRDPAIYRSLGILP-------PLRTA 207
Cdd:smart00630   81 AFQPVCRLRNL-------------------------------GELYVGTVADFSGSDPAIPRSLSVRRlkgtsgvSLRTV 129

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013    208 QYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEHD-CGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPF 286
Cdd:smart00630  130 LYDSKWLNEPNFVYAFESGDFVYFFFRETAVEDDnCGKAVHSRVARVCKNDVGGPRSLDKKWTSFLKARLECSVPGEDPF 209

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013    287 YYNELQSTFFLPEL----DLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPN-PNPHFQCGTVD 361
Cdd:smart00630  210 YFNELQAAFLLPPGsesdDVLYGVFSTSSNPIPGSAVCAFSLSDINAVFNGPFKECETSTSQWLPYSRgKVPYPRPGTCP 289

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013    362 QGLY--VNLTERNLQDAQKFILMHEVVQPVTTVPSFME--DNSRFSHVAVDVVQGREAlVHIIYLATDYGTIKKVRVPLN 437
Cdd:smart00630  290 NKPPssKDLPDETLNFIKSHPLMDEVVQPLTGRPLFVKtdSNYLLTSIAVDRVATDGN-YTVLFLGTSDGRILKVVLSES 368

                           410       420
                    ....*....|....*....|....
gi 578810013    438 QTSS-SCLLEEIELFPErrREPIR 460
Cdd:smart00630  369 SSSSeSVVLEEISVFPD--GSPIS 390
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
 291-466 1.84e-51

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 179.00  E-value: 1.84e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   291 LQSTFFLPEL------DLIYGIFTTN-VNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGT-VDQ 362
Cdd:pfam01403    1 LQDVFVLKPGagdaldTVLYGVFTTQwSNSIGGSAVCAFSLSDINAVFEGPFKEQEKSDSKWLPYTGKVPYPRPGTcIND 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   363 GLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTssS 442
Cdd:pfam01403   81 PLRLDLPDSVLNFVKDHPLMDEAVQPVGGRPLLVRTGVRLTSIAVDRVQALDGNYTVLFLGTDDGRLHKVVLVGSEE--S 158

                          170       180
                   ....*....|....*....|....
gi 578810013   443 CLLEEIELFPErrREPIRSLQILH 466
Cdd:pfam01403  159 HIIEEIQVFPE--PQPVLNLLLSS 180
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 844-896 2.61e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 76.47  E-value: 2.61e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 578810013    844 WSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPCP 896
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 598-651 7.78e-16

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 72.62  E-value: 7.78e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 578810013    598 WTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHlLCP 651
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQ-PCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 787-839 1.85e-15

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 71.46  E-value: 1.85e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 578810013    787 WSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQECNILPCP 839
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 656-702 1.13e-11

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 60.68  E-value: 1.13e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 578810013    656 WTGWGPWERCTAQCGGGIQARRRICENGP------DCAGCNVEYQSCNTNPCP 702
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPpqngggPCTGEDVETRACNEQPCP 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 599-647 1.50e-09

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 54.59  E-value: 1.50e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578810013   599 TPWTSWSPCSTTCGIGFQVRQRSCSNPtPRHGGRVCvGQNREERYCNEH 647
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLP 50
TSP_1 pfam00090
Thrombospondin type 1 domain;
845-895 2.53e-09

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 53.96  E-value: 2.53e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 578810013   845 SCWSPWTKCSATCGGGHYMRTRSCSNPAPayGGDICLGLHTEEALCNTQPC 895
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
788-838 6.16e-09

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 52.81  E-value: 6.16e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 578810013   788 SAWTSWSQCSRDCSRGIRNRKRVCNNPEPkyGGMPCLGPSLEYQECNILPC 838
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 486-533 2.53e-08

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 51.17  E-value: 2.53e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 578810013   486 RCQFYRTRSTCIGAQDPYCGWDVVMKKCTS----LEESLSMTQWEQSISACP 533
Cdd:pfam01437    1 RCSQYTSCSSCLAARDPYCGWCSSEGRCVRrsacGAPEGNCEEWEQASSKCP 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 544-595 7.15e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 49.89  E-value: 7.15e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 578810013    544 GVWSPWTPCTHTDGSAVgscLCRTRSCDSPAPQCGGWQCEGPGMEIANCSRN 595
Cdd:smart00209    2 SEWSEWSPCSVTCGGGV---QTRTRSCCSPPPQNGGGPCTGEDVETRACNEQ 50
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 899-940 8.38e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 46.81  E-value: 8.38e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 578810013    899 WSEWSDWSECEAS---GVQVRARQCIL--LFPMGSQCSGNTTESRPC 940
Cdd:smart00209    1 WSEWSEWSPCSVTcggGVQTRTRSCCSppPQNGGGPCTGEDVETRAC 47
TSP_1 pfam00090
Thrombospondin type 1 domain;
900-943 8.60e-07

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 46.64  E-value: 8.60e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 578810013   900 SEWSDWSECEAS---GVQVRARQCILLFPMGSQCSGNTTESRPCVFD 943
Cdd:pfam00090    1 SPWSPWSPCSVTcgkGIQVRQRTCKSPFPGGEPCTGDDIETQACKMD 47
TSP_1 pfam00090
Thrombospondin type 1 domain;
659-701 3.64e-06

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 44.72  E-value: 3.64e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 578810013   659 WGPWERCTAQCGGGIQARRRIC----ENGPDCAGCNVEYQSCNTNPC 701
Cdd:pfam00090    3 WSPWSPCSVTCGKGIQVRQRTCkspfPGGEPCTGDDIETQACKMDKC 49
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
486-524 1.21e-05

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 43.30  E-value: 1.21e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 578810013    486 RCQFYRTRSTCIGAQDPYCGWDVVMKKCTSLEESLSMTQ 524
Cdd:smart00423    1 RCSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQ 39
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 899-941 8.73e-04

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 43.01  E-value: 8.73e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 578810013  899 WSEWSDWSEC-----EASGVQVRARQCIllFPMGSQCSGNTTESRPCV 941
Cdd:PTZ00087  233 YTEWGEWSNCsmecdHPDNVQIRERKCA--HPSGDCFKGDLKETRPCQ 278
TSP_1 pfam00090
Thrombospondin type 1 domain;
544-593 2.92e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 36.63  E-value: 2.92e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 578810013   544 GVWSPWTPCTHTDGSAVGSclcRTRSCDSPAPqcGGWQCEGPGMEIANCS 593
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQV---RQRTCKSPFP--GGEPCTGDDIETQACK 45
 
Name Accession Description Interval E-value
Sema_5A cd11263
The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A); Originally, mouse ...
 50-485 0e+00

The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A); Originally, mouse Sema5A was identified as a protein that induces inhibitory responses during optic nerve development. Recent studies show that Sema5A controls innate immunity in mice. It also has been identified as a candidate gene for causing idiopathic autism in humans. Plexin B3 functions as a binding partner and receptor for Sema5A. Furthermore, Sema5A is also implicated in cancer. The role of the Drosophila Sema5A ortholog, Dsema-5C, in tumorigenicity and metastasis has been reported. Sema5A is highly expressed in human pancreatic cancer cells and is associated with tumor growth, invasion and metastasis. Sema5A belongs to class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200524 [Multi-domain]  Cd Length: 436  Bit Score: 977.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   50 FRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLF 129
Cdd:cd11263     1 FRAENAVDFSQLTFDPGQKELIVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  130 TCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQY 209
Cdd:cd11263    81 TCGTNAFTPICTNRTLNNLTEIHDQISGMARCPYSPQHNSTALLTSSGELYAATAMDFPGRDPAIYRSLGILPPLRTAQY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  210 NSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYN 289
Cdd:cd11263   161 NSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEIPFYYN 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  290 ELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGTVDQGLYVNLT 369
Cdd:cd11263   241 ELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAISQAFNGPFKYQENSRSAWLPYPNPNPNFQCGTMDQGLYVNLT 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  370 ERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTSSSCLLEEIE 449
Cdd:cd11263   321 ERNLQDAQKFILMHEVVQPVTPVPYFMEDNSRFSHVAVDVVQGKDMLFHIIYLATDYGTIKKVLAPLNQSSSSCLLEEIE 400

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 578810013  450 LFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLK 485
Cdd:cd11263   401 LFPKRQREPIRSLQILHSQSVLFVGLQEHVIKIPLK 436
Sema_5 cd11241
The Sema domain, a protein interacting module, of semaphorin 5 (Sema5); Class 5 semaphorins ...
 50-485 0e+00

The Sema domain, a protein interacting module, of semaphorin 5 (Sema5); Class 5 semaphorins are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. There are three subfamilies in class 5 semaphorins, namely 5A, 5B and 5C. Sema5A and Sema5B function as guidance cues for optic and corticofugal nerve development, respectively. Sema5A-induced cell migration requires Met signaling. Sema5C is an early development gene and may play a role in odor-guided behavior. Sema5A is also implicated in cancer. In a screening model for metastasis, the Drosophila Sema5A ortholog, Dsema-5C, has been found to be required in tumorigenicity and metastasis. Sema5A is highly expressed in human pancreatic cancer cells and is associated with tumor growth, invasion and metastasis. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200502 [Multi-domain]  Cd Length: 438  Bit Score: 781.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   50 FRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLF 129
Cdd:cd11241     1 FEIEYVSDFSRLVLDPTHDQLIVGARNYLFRLRLQSLSLLQAVPWNSDEDTKRQCQSKGKSVEECQNYVRVLLVVGKNLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  130 TCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQY 209
Cdd:cd11241    81 TCGTYAFSPVCTIRKLSNLTQILDTISGVARCPYSPAHNSTALISASGELYAGTVYDFSGRDPAIYRSLGGKPPLRTAQY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  210 NSKWLNEPNFVSSYDIGNFTYFFFRENAVEH-DCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYY 288
Cdd:cd11241   161 NSKWLNEPNFVGSYEIGNHTYFFFRENAVEHqDCGKTVYSRIARVCKNDIGGRFLLEDTWTTFMKARLNCSLPGEFPFYY 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  289 NELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGT-VDQGLYVN 367
Cdd:cd11241   241 NEIQGTFYLPETDLIYAVFTTNVNGIAGSAICAFNLSAINQAFNGPFKYQENNGSAWLPTPNPHPNFQCTTsIDRGQPAN 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  368 LTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGRE-ALVHIIYLATDYGTIKKVRVPLnQTSSSCLLE 446
Cdd:cd11241   321 TTERDLQDAQKYQLMAEVVQPVTKIPLVTMDDVRFSKLAVDVVQGRGtQLVHIFYVGTDYGTILKMYQPH-RSQKSCTLE 399

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 578810013  447 EIELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLK 485
Cdd:cd11241   400 EIKILPAMKGEPITSLQFLKSEKSLFVGLETGVLRIPLN 438
Sema_5B cd11264
The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed ...
 50-485 0e+00

The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed in regions of the basal telencephalon in rat. Sema5B is an inhibitory cue for corticofugal axons and acts as a source of repulsion for the appropriate guidance of cortical axons away from structures such as the ventricular zone as they navigate toward and within subcortical regions. In addition to its role as a guidance cue, Sema5B regulates the development and maintenance of synapse size and number in hippocampal neurons. In addition, the sema domain of Sema5B can be cleaved of the whole protein and exerts its function in regulation of synapse morphology. Sema5B belongs to the class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200525 [Multi-domain]  Cd Length: 437  Bit Score: 737.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   50 FRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLF 129
Cdd:cd11264     1 FTYPGVRDFSQLALDLNRNQLIVGARNYLFRLSLHNVSLIQATEWGSDEDTRRSCQSKGKTEEECQNYVRVLIVYGKKVF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  130 TCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQY 209
Cdd:cd11264    81 TCGTNAFSPVCTSRQVGNLSKVIERINGVARCPYDPRHNSTAVITSRGELYAATVIDFSGRDPAIYRSLGSVPPLRTAQY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  210 NSKWLNEPNFVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYN 289
Cdd:cd11264   161 NSKWLNEPNFIAAYDIGLFTYFFFRENAVEHDCGKTVYSRVARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEIPFYYN 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  290 ELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGTV-DQGLYVNL 368
Cdd:cd11264   241 ELQSTFYLPEQDLIYGVFTTNVNSIAASAVCAFNLSAITQAFNGPFRYQENPRSAWLPTANPIPNFQCGTLsDDSPNENL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  369 TERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTSSSCLLEEI 448
Cdd:cd11264   321 TERSLQDAQRLFLMNDVVQPVTVDPLVTQDSVRFSKLVVDIVQGKDTLYHVMYIGTEYGTILKALSTTNRSLRSCYLEEM 400

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 578810013  449 ELFPERRREPIRSLQILHSQSVLFVGLREHVVKIPLK 485
Cdd:cd11264   401 QILPPGQREPIRSLQILHSDRSLFVGLNNGVLKIPLE 437
Sema_5C cd11265
The Sema domain, a protein interacting module, of semaphorin 5C (sema5C); In Drosophila, ...
 50-483 8.32e-163

The Sema domain, a protein interacting module, of semaphorin 5C (sema5C); In Drosophila, Sema5C was identified as an early development gene, which is expressed in stage 2 embryos with a striped pattern emerging at later stages. Sema5c may play a role in odor-guided behavior and in tumorigenesis. Sema5C belongs to class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200526 [Multi-domain]  Cd Length: 433  Bit Score: 487.37  E-value: 8.32e-163
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   50 FRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRLF 129
Cdd:cd11265     1 FSDPEVTSYSQMLFDVARNQVIVGARDNLYRLSLDGLELLERASWPAAESKVALCQNKGQSEEDCHNYVKVLLSYGKQLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  130 TCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGI--LPPLRTA 207
Cdd:cd11265    81 ACGTNAFSPRCSWREMENLTSVTEWDSGVAKCPYSPHANITALLSSSGQLFVGSPTDFSGSDSAIYRTLGTsnKSFLRTK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  208 QYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEH-DCGKTVFSRAARVCKNDIGGR-FLLEDTWTTFMKARLNCSRPGEVP 285
Cdd:cd11265   161 QYNSKWLNEPQFVGSFETGNFVYFLFRESAVEYmNCGKVIYSRIARVCKNDVGGGtMLLKDNWTTFLKARLNCSLPGEYP 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  286 FYYNELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPN--PHFQCGTVDQG 363
Cdd:cd11265   241 FYFDEIQGMTYLPDEGILYATFTTPENSIAGSAVCAFNLSSINAAFDGPFKHQESSGAAWERVNVNHrdHFNQCSSSSSS 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  364 lyvnlterNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGR-EALVHIIYLATDYGTIKKVRVpLNQTSSS 442
Cdd:cd11265   321 --------HLLESSRYQLMDEAVQPITLEPLHHAKLERFSHIAVDVIPTKiHQSVHVLYVATTGGLIKKISV-LPRTQET 391

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 578810013  443 CLLEEIELFPERRRePIRSLQILHSQSVLFVGLREHVVKIP 483
Cdd:cd11265   392 CLVEIWQPLPTPDS-PIKTMQYLKVTDSLYVGTELALMRIP 431
Sema_semaphorin cd11235
The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator ...
 70-484 8.17e-157

The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. They can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted proteins; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. The semaphorins exert their function through their receptors, the neuropilin and plexin families. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200496 [Multi-domain]  Cd Length: 437  Bit Score: 471.89  E-value: 8.17e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   70 LVVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLL-VGGDRLFTCGTNAFTPVCTNRSLSNL 148
Cdd:cd11235    15 LYVGARDRVYLVDLDSLYTEQKVAWPSSPDDVDTCYLKGKSKDDCRNFIKVLEkNSDDSLLVCGTNAFNPSCRNYNVETF 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  149 TEIHDQISGMARCPYSPQHNSTALLtAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNF 228
Cdd:cd11235    95 ELVGKEESGRGKCPYDPDHNSTALF-ADGELYSGTSADFLGTDPVIYRTLGHNPPLRTEYHDSKWLNEPQFVGAFDIGDY 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  229 TYFFFRENAVEH-DCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPELD----LI 303
Cdd:cd11235   174 VYFFFREIAVEYiNCGKAVYSRVARVCKNDQGGSRSLEKKWTTFLKARLNCSVPGEFPFYFNELQDVFDLPSPSnkekIF 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  304 YGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPN---PNPH-FQCGTVDQglyvNLTERNLQDAQKF 379
Cdd:cd11235   254 YAVFTTPYNSIPGSAVCAYSLSDIEAVFNGPFKEQHSSNSAWLPVPDervPEPRpGTCVDDSS----PLPDDTLNFIKSH 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  380 ILMHEVVQPVTTVPSFM--EDNSRFSHVAVDVVQGREA-LVHIIYLATDYGTIKKVRVPLNQTSS-SCLLEEIELFPErr 455
Cdd:cd11235   330 PLMDEAVTPILNRPLFIktDVNYRFTKIAVDRVQAKLGqTYDVLFVGTDRGIILKVVSLPEQGLQaSNILEEMPVGPP-- 407

                         410       420
                  ....*....|....*....|....*....
gi 578810013  456 REPIRSLQILHSQSVLFVGLREHVVKIPL 484
Cdd:cd11235   408 PEPIQTMQLSRKRRSLYVGSETGVLQVPL 436
Sema_1A cd11237
The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A); Sema1A is a ...
 70-487 1.69e-130

The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A); Sema1A is a transmembrane protein. It has been shown to mediate the defasciculation of motor axon bundles at specific choice points. Sema1A binds to its receptor plexin A (PlexA), which in turn triggers downstream signaling events involving the receptor tyrosine kinase Otk, the evolutionarily conserved flavoprotein monooxygenase molecule interacting with CasL (MICAL), and the A kinase anchoring protein Nervy, leading to repulsive growth-cone response. Sema1A has also been shown to be involved in synaptic formation. It is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200498 [Multi-domain]  Cd Length: 446  Bit Score: 403.64  E-value: 1.69e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   70 LVVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVL-LVGGDRLFTCGTNAFTPVCT--NRSLS 146
Cdd:cd11237    17 LLVGARNAVYNISLSDLTENQRIEWPSSDAHREMCLLKGKSEDDCQNYIRVLaKKSAGRLLVCGTNAYKPLCReyTVKDG 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  147 NLTEIHDQiSGMARCPYSPQHNSTALLtAGGELYAATAMDFPGRDPAIYRSlgilpPLRTAQYNSKWLNEPNFVSSYDIG 226
Cdd:cd11237    97 GYRVEREF-DGQGLCPYDPKHNSTAVY-ADGQLYSATVADFSGADPLIYRE-----PLRTERYDLKQLNAPNFVSSFAYG 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  227 NFTYFFFRENAVEH-DCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPE------ 299
Cdd:cd11237   170 DYVYFFFRETAVEYiNCGKAIYSRVARVCKNDKGGPHPFRDRWTSFLKARLNCSVPGEYPFYFNEIQSTSDIVEggyggk 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  300 -LDLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPN-----PNPHfQCgtvdqglyVNlTERNL 373
Cdd:cd11237   250 sAKLIYGVFTTPVNSISGSAVCAFSLQDILEVFDGSFKEQQDINSNWLPVPSnkvpePRPG-QC--------VN-DSRTL 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  374 QD-AQKFI----LMHEVVQPVTTVPSFME--DNSRFSHVAVD--VVQGREALVHIIYLATDYG-TIKKVRVPLNQTSS-- 441
Cdd:cd11237   320 PDvTVNFIkshpLMDEAVPSFFGRPILVRtsLQYRFTQIAVDpqVKALDGKYYDVLFIGTDDGkVLKAVNIASADTVDkv 399

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 578810013  442 -SCLLEEIELFPerRREPIRSLQILHS--QSVLFVGLREHVVKIPLKRC 487
Cdd:cd11237   400 sPVVIEETQVFP--RGVPIRNLLIVRGkdDGRLVVVSDDEIVSIPLHRC 446
Sema smart00630
semaphorin domain;
58-460 4.26e-129

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 397.89  E-value: 4.26e-129
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013     58 FSQLTFDPGQKELVVGARNYLFRLQLEDLSLI-QAVEWECDEATKKACYSKGKSK-EECQNYIRVLL-VGGDRLFTCGTN 134
Cdd:smart00630    1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAeLKTGPVLSSPDCEECVSKGKDPpTDCVNYIRLLLdYNEDRLLVCGTN 80

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013    135 AFTPVCTNRSLsnlteihdqisgmarcpyspqhnstalltagGELYAATAMDFPGRDPAIYRSLGILP-------PLRTA 207
Cdd:smart00630   81 AFQPVCRLRNL-------------------------------GELYVGTVADFSGSDPAIPRSLSVRRlkgtsgvSLRTV 129

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013    208 QYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEHD-CGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPF 286
Cdd:smart00630  130 LYDSKWLNEPNFVYAFESGDFVYFFFRETAVEDDnCGKAVHSRVARVCKNDVGGPRSLDKKWTSFLKARLECSVPGEDPF 209

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013    287 YYNELQSTFFLPEL----DLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPN-PNPHFQCGTVD 361
Cdd:smart00630  210 YFNELQAAFLLPPGsesdDVLYGVFSTSSNPIPGSAVCAFSLSDINAVFNGPFKECETSTSQWLPYSRgKVPYPRPGTCP 289

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013    362 QGLY--VNLTERNLQDAQKFILMHEVVQPVTTVPSFME--DNSRFSHVAVDVVQGREAlVHIIYLATDYGTIKKVRVPLN 437
Cdd:smart00630  290 NKPPssKDLPDETLNFIKSHPLMDEVVQPLTGRPLFVKtdSNYLLTSIAVDRVATDGN-YTVLFLGTSDGRILKVVLSES 368

                           410       420
                    ....*....|....*....|....
gi 578810013    438 QTSS-SCLLEEIELFPErrREPIR 460
Cdd:smart00630  369 SSSSeSVVLEEISVFPD--GSPIS 390
Sema_6 cd11242
The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 ...
 70-484 2.66e-116

The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 semaphorins (Sema6s) are membrane associated semaphorins. There are 6 subfamilies named 6A to 6D. Sema6s bind to plexin As in a neuropilin independent fashion. Sema6-plexin A signaling plays important roles in lamina-specific axon projections. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. Interactions between Sema6C, Sema6D and plexin A1 shape the stereotypic trajectories of sensory axons in the spinal cord. In addition to axon targeting, Sema6D-plexin A1 interactions influence a wide range of other biological processes. During cardiac development, Sema6D attracts or repels endothelial cells in the cardiac tube depending on the expression patterns of specific coreceptors in addition to plexin A1. Furthermore, Sema6D binds a receptor complex comprising of plexin A1, Trem2 (triggering receptor expressed on myeloid cells 2), and DAP12 on dendritic cells and osteoclasts to mediate T-cell-DC interactions and to control bone development, respectively. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200503 [Multi-domain]  Cd Length: 465  Bit Score: 367.23  E-value: 2.66e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   70 LVVGARNYLFRLQL-----EDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLLVGGDR-LFTCGTNAFTPVCTNR 143
Cdd:cd11242    21 LYIAARDHVYTVDLdashtEEIVPSKKLTWRSRQADVENCRMKGKHKDECHNFIKVLVPRNDEtLFVCGTNAFNPVCRNY 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  144 SLSNLTEIHDQISGMARCPYSPQHNSTALLtAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSY 223
Cdd:cd11242   101 RIDTLEQDGEEISGMARCPFDAKQANVALF-ADGKLYSATVTDFLASDAVIYRSLGDSPTLRTVKYDSKWLKEPHFVHAV 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  224 DIGNFTYFFFRENAVEHD-CGKTVFSRAARVCKNDIGG-RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPEL- 300
Cdd:cd11242   180 EYGDYVYFFFREIAVEYNtLGKVVFSRVARVCKNDMGGsPRVLEKQWTSFLKARLNCSVPGDSHFYFDVLQAVTDVIRIn 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  301 --DLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPN---PNPHFQCGTVDQGLYVNLTERNLQD 375
Cdd:cd11242   260 grPVVLGVFTTQYNSIPGSAVCAFDMDDIEKVFEGRFKEQKSPDSAWTPVPEdrvPKPRPGCCAGSGSAEKYKTSNDFPD 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  376 -AQKFI----LMHEVVQPVTTVPSFMEDNSRF--SHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTSS--SCLLE 446
Cdd:cd11242   340 dTLNFIkthpLMDEAVPSIINRPWFTRTMVRYrlTQIAVDNAAGPYQNYTVVFLGSEAGTVLKFLARIGPSGSngSVFLE 419

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 578810013  447 EIELF-PER--------RRepIRSLQILHSQSVLFVGLREHVVKIPL 484
Cdd:cd11242   420 EIDVYnPAKcsydgeedRR--IIGLELDRASHALFVAFSGCVIRVPL 464
Sema_4 cd11240
The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 ...
 50-484 4.56e-112

The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 semaphorins (Sema4s) are transmembrane regulator molecules involved in the development of the nervous system, immune response, cytoskeletal organization, angiogenesis, and cell-cell interactions. There are 7 distinct subfamilies in class 4 semaphorins, named 4A to 4G. Several class 4 subfamilies play important roles in the immune system and are called "immune semaphorins". Sema4A plays critical roles in T cell-DC interactions in the immune response. Sema4D/CD100, expressed by lymphocytes, promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. It is required for normal activation of B and T lymphocytes. Sema4B negatively regulates basophil functions through T cell-basophil contacts and significantly inhibits IL-4 and IL-6 production from basophils in response to various stimuli, including IL-3 and papain. Sema4s not only influence the activation state of cells but also modulate their migration and survival. The effects of Sema4s on nonlymphoid cells are mediated by plexin D1 and plexin Bs. The Sema4G and Sema4C genes are expressed in the developing cerebellar cortex and are involved in neural tube closure and development of cerebellar granules cells through receptor plexin B2. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200501 [Multi-domain]  Cd Length: 456  Bit Score: 355.56  E-value: 4.56e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   50 FRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLI--QAVEWECDEATKKACYSKGKSKE-ECQNYIRVLLVGGD 126
Cdd:cd11240     1 FSQEGIQNYSTLLLSEDEGTLYVGAREALFALNVSDISTElkDKIKWEASEDKKKECANKGKDNQtDCFNFIRILQFYNS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  127 -RLFTCGTNAFTPVCTNRSLSNLTEIH-DQISGMARCPYSPQHNSTALLtAGGELYAATAMDFPGRDPAIYRSLGILPPL 204
Cdd:cd11240    81 tHLYVCGTFAFSPRCTYINLSDFSLSSiKFEDGKGRCPFDPAQRYTAIM-VDGELYSATVNNFLGSEPVISRNHSEGNVL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  205 RTaQYNSKWLNEPNFVSSY----DIGNFT------YFFFRENAVEHDCG-KTVFSRAARVCKNDIGGRFLLEDTWTTFMK 273
Cdd:cd11240   160 KT-ENTLRWLNEPAFVGSAhireSIDSPDgdddkiYFFFTETAVEYDFYeKVTVSRVARVCKGDLGGQRTLQKKWTTFLK 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  274 ARLNCSRPGEvPFYYNELQSTFFLPELD----LIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYP 349
Cdd:cd11240   239 AQLVCSQPDS-GLPFNVLRDVFVLSPDSwdatIFYGVFTSQWNVSGLSAVCAYSLEDIKKVFSGKYKEFNRETSKWSRYT 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  350 NPNPHFQ---CGT-----VDQGLYVNLTERNLQDAQKFILMHEVVQPVTTvPSFMEDNSRFSHVAVDVVQGREALVH-II 420
Cdd:cd11240   318 GPVPDPRpgaCITnsarsQGITSSLNLPDNVLTFVKDHPLMDEQVHPINR-PLLVKSGVNYTRIAVHRVQALDGQTYtVL 396

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578810013  421 YLATDYGTIKKVrVPLNqtSSSCLLEEIELFPErrREPIRSLQILHSQSVLFVGLREHVVKIPL 484
Cdd:cd11240   397 FLGTEDGFLHKA-VSLD--GGMHIIEEIQLFDQ--PQPVKNLLLSSSKGVLYVGSSSGVVQVPL 455
Sema_3 cd11239
The Sema domain, a protein interacting module, of class 3 semaphorins; Class 3 semaphorins ...
 54-487 1.66e-103

The Sema domain, a protein interacting module, of class 3 semaphorins; Class 3 semaphorins (Sema3s) are secreted regulator molecules involved in the development of the nervous system, vasculogenesis, angiogenesis,and tumorigenesis. There are 7 distinct subfamilies named Sema3A to 3G. Sema3s function as repellent signals during axon guidance by repelling neurons away from the source of Sema3s. However, Sema3s that are secreted by tumor cells play an inhibitory role in tumor growth and angiogenesis (specifically Sema3B and Sema3F). Sema3s functions by forming complexes with neuropilins and A-type plexins, where neuropilins serve as the ligand binding moiety and the plexins function as signal transduction component. Sema3s primarily inhibit the cell motility and migration of tumor and endothelial cells by inducing collapse of the actin cytoskeleton via neuropilins and plexins. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200500 [Multi-domain]  Cd Length: 471  Bit Score: 333.17  E-value: 1.66e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   54 NAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSL-IQAVEWECDEATKKACYSKGKSKE-ECQNYIRVL-LVGGDRLFT 130
Cdd:cd11239     6 NSLDYRSLLLDEDRDRLYVGGKDHILSLSLDNINQdPKKIYWPASPERIEECKMAGKDPNtECANFVRVLqPYNRTHLYA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  131 CGTNAFTPVCT----NRSLSNLT---EIHDQISGMARCPYSPQHNSTALLTaGGELYAATAMDFPGRDPAIYRSLGILPP 203
Cdd:cd11239    86 CGTGAFHPICAfinvGRRLEDPIfklDDSSLESGRGKCPFDPNQPFASVLI-DGELYSGTAIDFMGRDAAIFRSLGHRHY 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  204 LRTAQYNSKWLNEPNFVSSYDI-------GNFTYFFFRENAVEHD-CGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKAR 275
Cdd:cd11239   165 IRTEQYDSRWLNEPKFVGAYLIpdsdnpdDDKVYFFFREKAVEAEgSGKAIYSRVGRICKNDVGGQRSLVNKWSTFLKAR 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  276 LNCSRPGE--VPFYYNELQSTFFLPELD----LIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPY- 348
Cdd:cd11239   245 LVCSVPGPdgIDTYFDELEDVFLLPTRDpknpLIYGVFTTSSNVFKGSAVCVYSMADIRAAFNGPFAHKEGPNYQWVEYq 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  349 ---PNPNPhfqcGTVDQGLYVNL---TERNLQDAQKFI----LMHEVVQPVTTVPSFMEDNS--RFSHVAVDVVQGREAL 416
Cdd:cd11239   325 gkvPYPRP----GTCPSKTYGPLyksTKDFPDDVISFArshpLMYNPVYPLHGRPLLIRTNVpyRLTQIAVDRVEAEDGQ 400

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578810013  417 VHIIYLATDYGTIKKVRVPLNQTSSS--CLLEEIELFpeRRREPIRSLQILHSQSVLFVGLREHVVKIPLKRC 487
Cdd:cd11239   401 YDVLFIGTDSGTVLKVVSLPKENWEMeeVILEELQVF--KHPSPITSMEISSKRQQLYVGSAEGVVQLPLHRC 471
Sema_2A cd11238
The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted ...
 58-470 2.39e-100

The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted semaphorin, signals through its receptor plexin B (PlexB) to regulate central and peripheral axon pathfinding. In the Drosophila embryo, Sema2A secreted by oenocytes interacts with PlexB to guide sensory axons. Sema2A is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200499 [Multi-domain]  Cd Length: 452  Bit Score: 323.99  E-value: 2.39e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   58 FSQLTFDPGQKELVVGARNYLFRLQLEDLS----LIQAVEWECDEATKKACYSKGKSKE-ECQNYIRVLLV--GGDRLFT 130
Cdd:cd11238     3 YRTLLLDEKRNALYVGAMDRVFRLNLYNINdtgnNCARDELTLSPSDVSECVSKGKDEEyECRNHVRVIQPmgDGQTLYV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  131 CGTNAFTPvcTNRSL--SNLTEIHDQIS---GMARCPYSPQHNSTALLTAGGE------LYAATAMDFPGRDPAIYRslg 199
Cdd:cd11238    83 CSTNAMNP--KDRVLdaNLLHLPEYVPGpgnGIGKCPYDPDDNSTAVWVEWGNpgdlpaLYSGTRTEFTKANTVIYR--- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  200 ilPPL------------RTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEH-DCGKTVFSRAARVCKNDIGGRFLLED 266
Cdd:cd11238   158 --PPLynntkgrhesfmRTLKYDSKWLDEPNFVGSFDIGDYVYFFFRETAVEYiNCGKVVYSRVARVCKKDTGGKNVLRQ 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  267 TWTTFMKARLNCSRPGEVPFYYNELQSTFFLPELD--LIYGIFTTNVNSIAASAVCVFNLSAIAQAF-SGPFKYQENSRS 343
Cdd:cd11238   236 NWTTFLKARLNCSISGEFPFYFNEIQSVYKVPGRDdtLFYATFTTSENGFTGSAVCVFTLSDINAAFdTGKFKEQASSSS 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  344 AWLPYPNPN--PHF--QCgTVDQGlyvNLTERNLQDAQKFILMHEVVQpvTTVPSFMEDNSRFSHVAVDVVQGREALVHI 419
Cdd:cd11238   316 AWLPVLSSEvpEPRpgTC-VNDSA---TLSDTVLHFARTHPLMDDAVS--HGPPLLYLRDVVFTHLVVDKLRIDDQEYVV 389

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 578810013  420 IYLATDYGTIKK-VRVPLNQTSSSCLLEEIELFPErrrEPIRSLQILHSQSV 470
Cdd:cd11238   390 FYAGSNDGKVYKiVHWKDAGESKSNLLDVFELTPG---EPIRAMELLPGEFL 438
Sema_6B cd11267
The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as ...
 68-484 1.30e-99

The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as repellents for axon growth; this repulsive activity is mediated by its receptor Plexin A4. Sema6B is expressed in CA3, and repels mossy fibers in a Plexin A4 dependent manner. In human, it was shown that peroxisome proliferator-activated receptors (PPARs) and 9-cis-retinoic acid receptor (RXR) regulate human semaphorin 6B (Sema6B) gene expression. Sema6B is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200528 [Multi-domain]  Cd Length: 466  Bit Score: 322.55  E-value: 1.30e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   68 KELVVGARNYLFRLQLE-----DLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLLVGGDR-LFTCGTNAFTPVCT 141
Cdd:cd11267    19 RTLYIGDRDNLYRVELDptagtEMRYHKKLTWRSNKNDINVCRMKGKHEGECRNFIKVLLLRDYGtLFVCGTNAFNPVCA 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  142 NRSLSNLTEIHDQISGMARCPYSPQHNSTALLtAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVS 221
Cdd:cd11267    99 NYSIDTLEPVGDNISGMARCPYDPKHANVALF-ADGMLFTATVTDFLAIDAVIYRSLGDSPALRTVKHDSKWFKEPYFVH 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  222 SYDIGNFTYFFFRENAVE-HDCGKTVFSRAARVCKNDIGG-RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPE 299
Cdd:cd11267   178 AVEWGSHVYFFFREIAMEfNYLEKVVVSRVARVCKNDMGGsQRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVSDILN 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  300 L---DLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPN---PNPHFQCGTVdQGLYVNLTERNL 373
Cdd:cd11267   258 LggrPVVLAVFSTPTNSIPGSAVCAFDMTQVAAVFEGRFREQKSPESIWTPVPEelvPRPRPGCCAA-PGMRYNSSSTLP 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  374 QDAQKFI----LMHEVVQPVTTVPSFMEDNSRF--SHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTSS-----S 442
Cdd:cd11267   337 DEVLNFVkthpLMDEAVPSLGHAPWIVRTMTRYqlTHMVVDTEAGPHGNHTVVFLGSTRGTVLKFLIIPNASSSeisnqS 416

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 578810013  443 CLLEEIELF-PERRREPIRSLQILHSQSV------LFVGLREHVVKIPL 484
Cdd:cd11267   417 VFLEELETYnPERCGWDSPQAQKLLSLELdkgsggLLLAFPSCVVRVPV 465
Sema_6A cd11266
The Sema domain, a protein interacting module, of semaphorins 6A (Sema6A); In the cerebellum, ...
 67-484 6.99e-96

The Sema domain, a protein interacting module, of semaphorins 6A (Sema6A); In the cerebellum, Sema6A-plexin A2 signaling modulates granule cell migration by controlling centrosome positioning. Besides plexin A2, plexin A4 is also found to be a receptor of Sema6A. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. It is required for the clustering of boundary cap cells at the PNS/CNS interface and thus, prevents motoneurons from streaming out of the ventral spinal cord. At the dorsal root entry site, it organizes the segregation of dorsal roots. Sema6A may also be involved in axonal pathfinding processes in the periinfarct and homotopic contralateral cortex. Sema6A is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200527 [Multi-domain]  Cd Length: 466  Bit Score: 312.73  E-value: 6.99e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   67 QKELVVGARNYLFRLQL-----EDLSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLLV-GGDRLFTCGTNAFTPVC 140
Cdd:cd11266    18 NRTLYIAARDHIYTVDIdtshtEEIYFSKKLTWKSRQADVDTCRMKGKHKDECHNFIKVLLKrNDDTLFVCGTNAFNPSC 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  141 TNRSLSNLTEIHDQISGMARCPYSPQHNSTALLtAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFV 220
Cdd:cd11266    98 RNYKMDTLEFFGDEFSGMARCPYDAKHANVALF-ADGKLYSATVTDFLAIDAVIYRSLGDSPTLRTVKHDSKWLKEPYFV 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  221 SSYDIGNFTYFFFRENAVE-HDCGKTVFSRAARVCKNDIGG-RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLP 298
Cdd:cd11266   177 QAVDYGDYIYFFFREIAVEyNSMGKVVFPRVAQVCKNDMGGsQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVI 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  299 EL---DLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPN---PNPHFQCGTVDQGLYVNLTERN 372
Cdd:cd11266   257 HIngrDVVLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTWTPVPDervPKPRPGCCAGSSSLEKYATSNE 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  373 L-QDAQKFI----LMHEVVQPVTTVPSFMEDNSRF--SHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQT---SSS 442
Cdd:cd11266   337 FpDDTLNFIkthpLMDEAVPSIINRPWFLRTMVRYrlTKIAVDNAAGPYQNHTVVFLGSEKGIILKFLARTGNSgflNDS 416

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 578810013  443 CLLEEIELF-PER------RREPIRSLQILHSQSVLFVGLREHVVKIPL 484
Cdd:cd11266   417 LFLEEMNVYnSEKcsydgvEDKRIMGMQLDKASSALYVAFSTCVIKVPL 465
Sema_6D cd11269
The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D); Sema6D is expressed ...
 70-484 2.53e-95

The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D); Sema6D is expressed predominantly in the nervous system during embryogenesis and it uses Plexin-A1 as a receptor. It displays repellent activity for dorsal root ganglion axons. Sema6D also acts as a regulator of late phase primary immune responses. In addition, Sema6D is overexpressed in gastric carcinoma, indicating that it may have an important role in the occurrence and development of the cancer. Sema6D is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200530 [Multi-domain]  Cd Length: 465  Bit Score: 311.19  E-value: 2.53e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   70 LVVGARNYLFRLQLED-----LSLIQAVEWECDEATKKACYSKGKSKEECQNYIRVLLVGGDRL-FTCGTNAFTPVCTNR 143
Cdd:cd11269    21 LYIAGRDQVYTVNLNEvpkteVTPSRKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMvFVCGTNAFNPMCRYY 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  144 SLSNLTEIHDQISGMARCPYSPQHNSTALLtAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSY 223
Cdd:cd11269   101 RLSTLEYDGEEISGLARCPFDARQTNVALF-ADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAI 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  224 DIGNFTYFFFRENAVEH-DCGKTVFSRAARVCKNDIGG-RFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPELD 301
Cdd:cd11269   180 EYGNYVYFFFREIAVEHnNLGKAVYSRVARICKNDMGGsQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIEIN 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  302 ---LIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPN---PNPHFQCgTVDQGL------YVNLT 369
Cdd:cd11269   260 gipTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEdkvPKPRPGC-CAKHGLaeayktSIDFP 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  370 ERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRF--SHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTS--SSCLL 445
Cdd:cd11269   339 DETLSFIKSHPLMDSAVPSIIEEPWFTKTRVRYrlTAIAVDHAAGPHQNYTVIFVGSEAGVVLKILAKTSPFSlnDSVLL 418

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 578810013  446 EEIELF---------PERRRepIRSLQILHSQSVLFVGLREHVVKIPL 484
Cdd:cd11269   419 EEIEAYnhakcsaenEEDRR--VISLQLDRDHHALFVAFSSCVVRIPL 464
Sema_3F cd11254
The Sema domain, a protein interacting module, of semaphorin 3F (Sema3F); Sema3F is ...
 54-487 3.80e-88

The Sema domain, a protein interacting module, of semaphorin 3F (Sema3F); Sema3F is coexpressed with semaphorin3B. Both Sema3B and Sema3F proteins are candidate tumor suppressors that are down-regulated in highly metastatic tumors. Two receptor families, the neuropilins and plexins, have been implicated in mediating the actions of semaphorins 3B and 3F. Sema3F is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200515 [Multi-domain]  Cd Length: 470  Bit Score: 291.73  E-value: 3.80e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   54 NAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLS---LIqaVEWECDEATKKACYSKGK-SKEECQNYIRVLL-VGGDRL 128
Cdd:cd11254     6 NTSDYRILLKDEDHDRMYVGSKDYVLSLDLHDINrepLI--IHWPASPQRIEECILSGKgSNGECGNFIRLIQpWNRTHL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  129 FTCGTNAFTPVCT--NRSLSNLTEIHDQI-----SGMARCPYSPQHNSTALLTaGGELYAATAMDFPGRDPAIYRSLGIL 201
Cdd:cd11254    84 YVCGTGAYNPVCAyiNRGRRAEDYMFRLEpdkleSGKGKCPYDPKQDSVSALI-NGELYAGVYIDFMGTDAAIFRTMGKQ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  202 PPLRTAQYNSKWLNEPNFVSSYDIGNFT-------YFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKA 274
Cdd:cd11254   163 PAMRTDQYNSRWLNDPAFVHAHLIPDSSeknddklYFFFREKSLEAPQSPAVLSRIGRVCLNDDGGHCCLVNKWSTFLKA 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  275 RLNCSRPGE--VPFYYNELQSTFFLPELD----LIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPY 348
Cdd:cd11254   243 RLVCSVPGAdgIETHFDELRDVFIQPTQDtknpVIYAVFSTSGSVFKGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPY 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  349 PNPNPHFQCGTVDQGLYV--NLTERNLQD-AQKFI----LMHEVVQPVTTVPSFMEDNS--RFSHVAVDVVQGREALVHI 419
Cdd:cd11254   323 TGKIPYPRPGTCPGGTFTpsMKSTKDYPDeVINFMrthpLMYNAVYPVHRRPLVVRTNVnyRFTTIAVDQVDAADGRYEV 402

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  420 IYLATDYGTIKKVRV-PLNQ-TSSSCLLEEIELFpeRRREPIRSLQILHSQSVLFVGLREHVVKIPLKRC 487
Cdd:cd11254   403 LFLGTDRGTVQKVIVlPKDDlETEELTLEEVEVF--KVPAPIKTMKISSKRQQLYVSSAVGVTHLSLHRC 470
Sema_3B cd11250
The Sema domain, a protein interacting module, of semaphorin 3B (Sema3B); Sema3B is ...
 58-487 1.31e-84

The Sema domain, a protein interacting module, of semaphorin 3B (Sema3B); Sema3B is coexpressed with semaphorin 3F and both proteins are candidate tumor suppressors. Both Sema3B and Sema3F show high levels of expression in normal tissues and low-grade tumors but are down-regulated in highly metastatic tumors in the lung, melanoma cells, bladder carcinoma cells and prostate carcinoma. They are upregulated by estrogen and inhibit cell motility and invasiveness through decreased FAK phosphorylation and inhibition of MMP-2 and MMP-9 expression. Two receptor families, the neuropilins (NP) and plexins, have been implicated in mediating the actions of semaphorins 3B and 3F. Sema3B is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200511 [Multi-domain]  Cd Length: 471  Bit Score: 282.19  E-value: 1.31e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   58 FSQLTFDPGQKELVVGARNYLFRLQLEDLS-LIQAVEWECDEATKKACYSKGKS-KEECQNYIRVL-LVGGDRLFTCGTN 134
Cdd:cd11250    10 YDALLLDEERGRLFVGAKNYLASLSLDNISkQEKKIYWPAPVEWREECNWAGKDiNTDCMNYVKILhHYNRTHLYACGTG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  135 AFTPVCTNRSLSNLTEIH----DQIS---GMARCPYSPQHNSTALLtAGGELYAATAMDFPGRDPAIYRSLGILPPLRTA 207
Cdd:cd11250    90 AFHPTCAFVEVGQRMEDHvfrlDPSRvedGKGKSPYDPRHTAASVL-VGDELYSGVATDLMGRDFTIFRSLGQRPSLRTE 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  208 QYNSKWLNEPNFVSSYDI-------GNFTYFFFRENAVE-HDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCS 279
Cdd:cd11250   169 QHDSRWLNEPKFVKVFWIpesenpdDDKIYFFFRETAVEaAGLGKQSYSRIGQICRNDMGGQRSLVNKWTTFLKARLVCS 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  280 RPGE--VPFYYNELQSTFFLPELD----LIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPY----P 349
Cdd:cd11250   249 VPGNegGDTHFDELRDVFLLQTRDkrnpLIYAVFSTSSSVFQGSAVCVYTMNDVRRAFLGPFAHKEGPNYQWVSYqgkvP 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  350 NPNPHFqCGTVDQGLYV---NLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNS--RFSHVAVDVVQGREALVHIIYLAT 424
Cdd:cd11250   329 YPRPGM-CPSKTFGSFEstkDFPDDVIQFARNHPLMFNPVLPLGGRPLFLRTGIpyTFTQIAVDRVAAADGHYDVMFIGT 407

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578810013  425 DYGTIKKV-RVPLN--QTSSSCLLEEIELFpeRRREPIRSLQILHSQSVLFVGLREHVVKIPLKRC 487
Cdd:cd11250   408 DVGSVLKViSVPKGswPSNEELLLEELHVF--KDSSPITSMQISSKRQQLYVGSRSGVSQLPLHRC 471
Sema_3A cd11249
The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A); Sema3A has been ...
 38-487 1.11e-83

The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A); Sema3A has been reported to inhibit the growth of certain experimental tumors and to regulate endothelial cell migration and apoptosis in vitro, as well as arteriogenesis in the muscle, skin vessel permeability, and tumor angiogenesis in vivo. The function of Sema3A is mediated through receptors neuropilin-1 (NP1) and plexins, although little is known about the requirement of specific plexins in its receptor complex. It is known however that Plexin-A4 is the receptor for Sema3A in the Toll-like receptor- and sepsis-induced cytokine storm during immune response. Sema3A is a member of the Class 3 semaphorin family of secreted proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200510 [Multi-domain]  Cd Length: 493  Bit Score: 280.35  E-value: 1.11e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   38 ISYKEIgpwlreFRAKNAVDFSQL-------TF--DPGQKELVVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKG 108
Cdd:cd11249     9 LSYKEM------LESNNLITFNGLansssyhTFllDEERGRLYVGAKDHIFSFNLVNIKDFQKIVWPVSPSRRDECKWAG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  109 KS-KEECQNYIRVL-LVGGDRLFTCGTNAFTPVCT-----NRSLSNLTEIHDQI--SGMARCPYSPQHNSTALLTaGGEL 179
Cdd:cd11249    83 KDiLKECANFIKVLkAYNQTHLYACGTGAFHPVCTyievgHHPEDNIFRLEDSHfeNGRGKSPYDPKLLTASLLI-DGEL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  180 YAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDI-------GNFTYFFFRENAV--EHdCGKTVFSRA 250
Cdd:cd11249   162 YSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPRFISAHLIpesdnpeDDKIYFFFRENAIdgEH-TGKATHARI 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  251 ARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGE--VPFYYNELQSTFFL----PELDLIYGIFTTNVNSIAASAVCVFNL 324
Cdd:cd11249   241 GQLCKNDFGGHRSLVNKWTTFLKARLICSVPGPngIDTHFDELQDVFLMnskdPKNPIVYAVFTTSSNIFKGSAVCMYSM 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  325 SAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGTVDQGLYVNL-TERNLQD-----AQKFILMHEVVQPVTTVPSFM-- 396
Cdd:cd11249   321 TDIRRVFLGPYAHRDGPNYQWVPFQGRVPYPRPGTCPSKTFGGFdSTKDLPDdvitfARSHPAMYNPVFPINNRPIIIkt 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  397 EDNSRFSHVAVDVVQGREALVHIIYLATDYGTI-KKVRVPLNQTS--SSCLLEEIELFperrREP--IRSLQILHSQSVL 471
Cdd:cd11249   401 DVDYQFTQIVVDRVEAEDGQYDVMFIGTDMGTVlKVVSIPKETWHdlEEVLLEEMTVF----REPtaISAMELSTKQQQL 476

                         490
                  ....*....|....*.
gi 578810013  472 FVGLREHVVKIPLKRC 487
Cdd:cd11249   477 YIGSAIGVSQLPLHRC 492
Sema_6E cd11270
The Sema domain, a protein interacting module, semaphorin 6E (sema6E); Sema6E is expressed ...
 68-484 4.81e-82

The Sema domain, a protein interacting module, semaphorin 6E (sema6E); Sema6E is expressed predominantly in the nervous system during embryogenesis. It binds Plexin A1 and might utilize it as a receptor to repel axons of specific types during development. Sema6E acts as a repellent to dorsal root ganglion axons as well as sympathetic axons. Sema6E is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200531 [Multi-domain]  Cd Length: 462  Bit Score: 275.06  E-value: 4.81e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   68 KELVVGARNYLFRLQL----EDLSLIQAVEWECDEAtkKACYSKGKSKEECQNYIRVLLVGGDR-LFTCGTNAFTPVCTN 142
Cdd:cd11270    19 HMVYIAARDHVFAINLsaslERIVPQQKLTWKTKDV--EKCTVRGKNSDECYNYIKVLVPRNDEtLFACGTNAFNPTCRN 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  143 RSLSNLTEIHDQISGMARCPYSPQHNSTALLtAGGELYAATAMDFPGRDPAIYRSLGILPP-LRTAQYNSKWLNEPNFVS 221
Cdd:cd11270    97 YKMSSLEQDGEEVIGQARCPFESRQSNVGLF-AGGDFYSATMTDFLASDAVIYRSLGESSPvLRTVKYDSKWLREPHFLH 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  222 SYDIGNFTYFFFRENAVEHDC-GKTVFSRAARVCKNDIGGR-FLLEDTWTTFMKARLNCSRPGEVPFYYNELQSTFFLPE 299
Cdd:cd11270   176 AIEYGNYVYFFLSEIAVEYTTlGKVVFSRVARVCKNDNGGSpRVLERYWTSFLKARLNCSVPGDSFFYFDVLQSLTNVMQ 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  300 LD---LIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPN---PNPHFQC--GTVDQGLYVNLTE- 370
Cdd:cd11270   256 INhrpAVLGVFTTQANSITGSAVCAFYMDDIEKVFNGKFKEQRNSESAWTPVPDeavPKPRPGScaGDGPAAGYKSSTNf 335

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  371 --RNLQDAQKFILMHEVVQPVTTVPSFMEDNSRF--SHVAVDVVQGREALVHIIYLATDYGTIKKVR--VPLNQTSSSCL 444
Cdd:cd11270   336 pdETLTFIKSYPLMDEAVPSVNNRPCFTRTTSRFklTQIAVDTAAGPYKNYTVVFLGSENGHVLKVLasMHPNSSYSTQV 415

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 578810013  445 LEEIELF--------PERRRepIRSLQILHSQSVLFVGLREHVVKIPL 484
Cdd:cd11270   416 LEDIDVYnpnkcnvrGEDRR--ILGLELDKDHHALFVAFTGCVIRVPL 461
Sema_4A cd11256
The Sema domain, a protein interacting module, of semaphorin 4A (Sema4A); Sema4A is expressed ...
 50-484 7.54e-81

The Sema domain, a protein interacting module, of semaphorin 4A (Sema4A); Sema4A is expressed in immune cells and is thus termed an "immune semaphorin". It plays critical roles in T cell-DC interactions in the immune response. It has been reported to enhance activation and differentiation of T cells in vitro and generation of antigen-specific T cells in vivo. The function of Sema4A in the immune response implicates its role in infectious and noninfectious diseases. Sema4A exerts its function through three receptors, namely Plexin B, Plexin D1, and Tim-2. Sema4A belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. TThe Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200517 [Multi-domain]  Cd Length: 447  Bit Score: 271.01  E-value: 7.54e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   50 FRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQA---VEWECDEATKKACYSKGKSKE-ECQNYIRVLL-VG 124
Cdd:cd11256     2 FRQENVHNYDQLLLSPDETTLYVGARDNILALGIRTPGPIRLkhqIPWPANDSKISECAFKKKSNEtECFNFIRVLVpVN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  125 GDRLFTCGTNAFTPVCTNRSLSNLT---EIHDQI--SGMARCPYSPQHNSTALLTaGGELYAATAMDFPGRDPAIYRSLG 199
Cdd:cd11256    82 GTHLYTCGTYAFSPACTYIELDHFSlppPNGTIItmDGKGQSPFDPQHNYTAILV-DGELYTGTMNNFRGNEPIIFRNLG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  200 ILPPLRTAQYNsKWLN-EPNFVSSYDI--GNFTYFFFRENAVEHDC-GKTVFSRAARVCKNDIGGRFLLEDTWTTFMKAR 275
Cdd:cd11256   161 TKVSLKTDGFL-RWLNaDAVFVASFNPqgDSKVYFFFEETAREFDFfEKLTVARVARVCKNDVGGEKLLQKKWTTFLKAQ 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  276 LNCSRPGEVPFyyNELQSTFFLPELD----LIYGIFTT--NVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYP 349
Cdd:cd11256   240 LTCSQQGHFPF--NVIHHVALLNQPDpnnsVFYAVFTSqwQLGGRRSSAVCAYKLNDIEKVFNGKYKELNKESSRWTRYM 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  350 NPNPHFQCGTVDQGLYvnlTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVH-IIYLATDYGT 428
Cdd:cd11256   318 GPVSDPRPGSCSGGKS---SDKALNFMKDHFLMDEVVLPGAGRPLLVKSNVQYTRIAVDSVQGVSGHNYtVMFLGTDKGF 394

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 578810013  429 IKKVRVPlnQTSSSCLLEEIELFPErrREPIRSLQILHSQSVLFVGLREHVVKIPL 484
Cdd:cd11256   395 LHKAVLM--GGSESHIIEEIELLTP--PEPVENLLLAANEGVVYIGYSAGVWRVPL 446
Sema_3D cd11252
The Sema domain, a protein interacting module, of semaphorin 3D (Sema3D); Sema3D is a secreted ...
 57-487 4.22e-79

The Sema domain, a protein interacting module, of semaphorin 3D (Sema3D); Sema3D is a secreted semaphorin expressed during the development of the nervous system. In zebrafish, Sema3D is expressed in the ventral tectum. It guides retinal axons along the dorsoventral axis of the tectum and guides the laterality of retinal ganglion cell (RGC) projections. Both Sema3D knockdown or its ubiquitous overexpression induced aberrant ipsilateral projections. Proper balance of Sema3D is needed at the midline for the progression of RGC axons from the chiasm midline into the contralateral optic tract. Sema3D is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200513 [Multi-domain]  Cd Length: 474  Bit Score: 267.16  E-value: 4.22e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   57 DFSQLTFDPGQKELVVGARNYLFRLQLEDLSL-IQAVEWECDEATKKACYSKGKSKE-ECQNYIRVLL-VGGDRLFTCGT 133
Cdd:cd11252     9 DFQTLLLDEERGRLLLGAKDHIYLLDLVDLNKnPKKIYWPAAKERVELCKLAGKDANtECANFIRVLHpYNRTHVYVCGT 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  134 NAFTPVCTNRSLSNLTE-------IHDQISGMARCPYSPQHNSTALLTaGGELYAATAMDFPGRDPAIYRSLGILPP--- 203
Cdd:cd11252    89 GAFHPTCGYIELGTHKEdriflldTQNLESGRLKCPFDPQQPFASVMT-DEYLYAGTASDFLGKDTTFTRSLGPTPDhhy 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  204 LRTAQYNSKWLNEPNFVSSYDIGNF-------TYFFFRENAVEHDCG-KTVFSRAARVCKNDIGGRFLLEDTWTTFMKAR 275
Cdd:cd11252   168 IRTDISEHYWLNGAKFIGTFPIPDTynpdddkIYFFFREASQDGSTSdKSVLSRVGRVCKNDVGGQRSLINKWTTFLKAR 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  276 LNCSRPGE--VPFYYNELQSTFFLPELD----LIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYP 349
Cdd:cd11252   248 LVCSIPGPdgADTHFDELQDIFLLPTRDernpVVYGVFTTTSSIFKGSAVCVYSMADIRAVFNGPYAHKESPDHRWVQYE 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  350 NPNPHFQCGTVDQGLY---VNLTERNLQDAQKFI----LMHEVVQPVTTVPSFMEDNS--RFSHVAVDVVQGREALVHII 420
Cdd:cd11252   328 GRIPYPRPGTCPSKTYdplIKSTKDFPDEVISFIkrhpLMYKSVYPLTGGPVFTRINVdyRLTQIVVDHVAAEDGQYDVM 407

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  421 YLATDYGTIKKVrVPLNQ---TSSSCLLEEIELFpeRRREPIRSLQILHSQSVLFVGLREHVVKIPLKRC 487
Cdd:cd11252   408 FLGTDIGTVLKV-VSITKekwTMEEVVLEELQIF--KHPSPILNMELSLKQQQLYIGSRDGLVQLSLHRC 474
Sema_6C cd11268
The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called ...
 52-484 9.55e-79

The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called semaphorin Y); Sema6C is highly expressed in adult brain and skeletal muscle and it shows growth cone collapsing activity. It may play a role in the maintenance and remodelling of neuronal connections. In adult skeletal muscle, this role includes prevention of motor neuron sprouting and uncontrolled motor neuron growth. The expression of Sema6C in adult skeletal muscle is down-regulated following denervation. Sema6C is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200529 [Multi-domain]  Cd Length: 465  Bit Score: 265.80  E-value: 9.55e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   52 AKNAVDFSQ-LTFDpgqKELVVGARNYLFRLQL------EDLSLIQAVEWECDEAtkKACYSKGKSKEECQNYIRVLLV- 123
Cdd:cd11268     5 AELGLDFQRfLTLN---RTLLVAARDHVFSFDLqaeeegEGLVPNKYLTWRSQDV--ENCAVRGKLTDECYNYIRVLVPw 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  124 GGDRLFTCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLtAGGELYAATAMDFPGRDPAIYRSLGILPP 203
Cdd:cd11268    80 DSQTLLACGTNSFSPVCRSYGITSLQQEGEELSGQARCPFDATQSNVAIF-AEGSLYSATAADFQASDAVVYRSLGPQPP 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  204 LRTAQYNSKWLNEPNFVSSYDIGNFTYFFFRENAVEH-DCGKTVFSRAARVCKNDIGGR-FLLEDTWTTFMKARLNCSRP 281
Cdd:cd11268   159 LRSAKYDSKWLREPHFVQALEHGDHVYFFFREVSVEDaRLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVP 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  282 GEVPFYYNELQS---TFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLP-----YPNPNP 353
Cdd:cd11268   239 GDSTFYFDVLQAltgPVNLHGRSALFGVFTTQTNSIPGSAVCAFYLDEIERGFEGKFKEQRSLDGAWTPvsedrVPSPRP 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  354 HFQCGTVDQGLYVnlTERNL-QDAQKFILMHEV----VQPVTTVPSF-MEDNSRFSHVAVDVVQGREALVHIIYLATDYG 427
Cdd:cd11268   319 GSCAGVGGAALFS--SSRDLpDDVLTFIKAHPLldpaVPPVTHQPLLtLTSRALLTQVAVDGMAGPHSNITVMFLGSNDG 396

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578810013  428 TIKKVRVPLNQTS--SSCLLEEIELFPERRREPIRS---------LQILHSQSVLFVGLREHVVKIPL 484
Cdd:cd11268   397 TVLKVLPPGGRSGgpEPILLEEIDAYSPARCSGKRTaqtarriigLELDTEGHRLFVAFSGCIVYLPL 464
Sema_3E cd11253
The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E); Sema3E is a secreted ...
 56-487 1.38e-78

The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E); Sema3E is a secreted molecule implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. It is also highly expressed in metastatic cancer cells. Sema3E signaling, through its high affinity functional receptor Plexin D1, drives cancer cell invasiveness and metastatic spreading. Sema3E is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200514 [Multi-domain]  Cd Length: 471  Bit Score: 265.56  E-value: 1.38e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   56 VDFSQLTFDPGQKELVVGARNYLFRLQLEDLSL-IQAVEWECDEATKKACYSKGKSKEECQNYIRVLL-VGGDRLFTCGT 133
Cdd:cd11253     8 LDLHTMLLDEYQERLFVGGRDLLYSLSLERISAnYKEIHWPSTQLQVEDCIMKGRDKPECANYIRVLHhYNRTHLLACGT 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  134 NAFTPVCTNRSLSNLTEIH------DQI-SGMARCPYSPQHNSTALLTaGGELYAATAMDFPGRDPAIYRSLGILPPLRT 206
Cdd:cd11253    88 GAFDPVCAFIRVGRGSEDHlfqlesDKFeRGRGRCPFDPNSSFISTLI-GGELFVGLYSDYWGRDAAIFRTMNHLAHIRT 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  207 AQYNSKWLNEPNFVSSYDI-------GNFTYFFFRENAVEHDCG-KTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNC 278
Cdd:cd11253   167 EHDDERLLKEPKFVGSYMIpdnedpdDNKVYFFFTEKALEAEGGnHAIYTRVGRVCANDQGGQRMLVNKWSTFLKTRLIC 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  279 SRPGE--VPFYYNELQSTFFLPELD----LIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAW------L 346
Cdd:cd11253   247 SVPGPngIDTHFDELEDVFLLRTRDnknpEIFGLFSTTSNIFKGYAICVYHMASIRAAFNGPFAHKEGPEYHWsvyegkV 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  347 PYPNPNphfQCGT-VDQGLYVNLTE---RNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFS--HVAVDVVQGREALVHII 420
Cdd:cd11253   327 PYPRPG---SCASkVNGGHYGTTKDypdEALRFARSHPLMYQAVKPVHKRPILVKTDGKYNlkQIAVDRVEAEDGQYDVL 403

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  421 YLATDYGTIKKVRVPLNQTSSS---CLLEEIELFpeRRREPIRSLQILHSQSVLFVGLREHVVKIPLKRC 487
Cdd:cd11253   404 FIGTDNGIVLKVITIYNQETETmeeVILEELQVF--KVPVPIISMEISSKRQQLYIGSESGVAQIRFHQC 471
Sema_4B cd11257
The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B); Sema4B, expressed in ...
 50-484 3.86e-77

The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B); Sema4B, expressed in T and B cells, is an immune semaphorin. It functions as a negative regulatory of basophils through T cell-basophil contacts and it significantly inhibits IL-4 and IL-6 production from basophils in response to various stimuli, including IL-3 and papain. In addition, T cell-derived Sema4B suppresses basophil-mediated Th2 skewing and humoral memory responses. Sema4B may be also involved in lung cancer cell mobility by inducing the degradation of CLCP1 (CUB, LCCL-homology, coagulation factor V/VIII homology domains protein). Sema4B is characterized by a PDZ-binding motif at the carboxy-terminus, which mediates interaction with the post-synaptic density protein PSD-95/SAP90, which is thought to play a central role during synaptogenesis and in the structure and function of post-synaptic specializations of excitatory synapses. Sema4B belongs to class 4 transmembrane semaphorin family proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200518 [Multi-domain]  Cd Length: 464  Bit Score: 261.33  E-value: 3.86e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   50 FRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLS---LIQAVEWECDEATKKACYSKGKS-KEECQNYIRVLL-VG 124
Cdd:cd11257     2 FEAEGVSNYTALLLSKDGNMLYVGARETLFALSSNDISptgEQQELTWSADEEKKQECSFKGKDpQRDCQNYIKILLrLN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  125 GDRLFTCGTNAFTPVCTNRSLSNLTEIHDQI------SGMARCPYSPQHNSTALlTAGGELYAATAMDFPGRDPAIYRSL 198
Cdd:cd11257    82 STHLFTCGTYAFSPICTYIVMTNFSLERDEKgeplleDGKGRCPFDPEYKSTAI-MVDGELYTGTVSNFQGNDPIIYRSL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  199 GILPPLRTAqyNS-KWLNEPNFVSSYDI----------GNFTYFFFRENAVEHDC-GKTVFSRAARVCKNDIGGRFLLED 266
Cdd:cd11257   161 GSGTPLKTE--NSlNWLQDPAFVGSAYIqeslpklvgdDDKIYFFFSETGKEFDFfENTIVSRIARVCKGDEGGERVLQK 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  267 TWTTFMKARLNCSRPGEvPFYYNELQSTFFLPELD------LIYGIFTTNVNSIAA--SAVCVFNLSAIAQAFSGPFKYQ 338
Cdd:cd11257   239 RWTTFLKAQLLCSLPDD-GFPFNVLQDVFVLTPSPedwkdtLFYGVFTSQWHKGTAgsSAVCVFTMDQVQRAFNGLYKEV 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  339 ENSRSAWLPYPNPNPHFQCGT----------VDQGLyvNLTERNLQDAQKFILMHevvQPVTTVPSFMEDNSRFSHVAVD 408
Cdd:cd11257   318 NRETQQWYTYTHPVPEPRPGAcitnsarerkINSSL--HMPDRVLNFVKDHFLMD---GQVRSQPLLLQPQVRYTQIAVH 392

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578810013  409 VVQGREALVHIIYLATDYGTIKKVrvpLNQTSSSCLLEEIELFPErrREPIRSLQILHSQSVLFVGLREHVVKIPL 484
Cdd:cd11257   393 RVKGLHKTYDVLFLGTDDGRLHKA---VSVGPMVHIIEELQIFSE--GQPVQNLLLDTHKGLLYASSHSGVVQVPV 463
Sema_4C cd11258
The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C); Sema4C acts as a ...
 47-484 1.25e-76

The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C); Sema4C acts as a Plexin B2 ligand to regulate the development of cerebellar granule cells and to modulate ureteric branching in the developing kidney. The binding of Sema4C to Plexin B2 results the phosphorylation of downstream regulator ErbB-2 and the plexin protein itself. The cytoplasmic region of Sema4C binds a neurite-outgrowth-related protein SFAP75, suggesting that Sema4C may also play a role in neural function. Sema4C belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200519 [Multi-domain]  Cd Length: 458  Bit Score: 259.73  E-value: 1.25e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   47 LREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVEWECDEATKKACYSKGKSKE-ECQNYIRVLL-VG 124
Cdd:cd11258     1 VRRFSQVGVSNYTTLTLAEHRGLLYVGAREAIFALSLSNIELQPPISWEAPAEKKTECAQKGKSNQtECFNYIRFLQpYN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  125 GDRLFTCGTNAFTPVCTNRSLSNLTEIHDQIS-GMARCPYSPQHNSTALLTaGGELYAATAMDFPGRDPAIYRSLGILPP 203
Cdd:cd11258    81 QSHLYTCGTYAFQPKCAYINMLTFTLDRAEFEdGKGKCPYDPAKGHTGLIV-DGELYSATLNNFLGTEPVILRNLGQHYS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  204 LRTaQYNSKWLNEPNFVSSY----DIGNFT------YFFFRENAVEHDC-GKTVFSRAARVCKNDIGGRFLLEDTWTTFM 272
Cdd:cd11258   160 MKT-EYLAFWLNEPHFVGSAfvpeSVGSFTgdddkiYFFFSERAVEYDCdSEQVVARVARVCKGDLGGARTLQKKWTTFL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  273 KARLNCSRPgEVPFYYNELQSTFFLPELDL----IYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPY 348
Cdd:cd11258   239 KARLLCSIP-EWQLYFNQLKAVFTLEGASWrnttFFAVFQARWGDMDVSAVCEYQLGEIQQVFEGPYKEYSEQAQKWGRY 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  349 PNPNPHFQCGTV------DQGLY--VNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQG-REALVHI 419
Cdd:cd11258   318 TDPVPSPRPGSCinnwhrDHGYTssLELPDNTLNFVKKHPLMEDRVKPRLGRPLLVPCNSNFTHVVWTRVLGlDGETYSV 397

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578810013  420 IYLATDYGTIKKVrVPLNqtSSSCLLEEIELFpeRRREPIRSLQILHSQSVLFVGLREHVVKIPL 484
Cdd:cd11258   398 LFIGTLDGWLIKA-VSLG--SWVHMIEELQVF--DQEPPESLVVSQSSKKLLFAGSRSELLQLPW 457
Sema_4E cd11260
The Sema domain, a protein interacting module, of semaphorin 4E (Sema4E); Sema4E is expressed ...
 50-484 3.96e-75

The Sema domain, a protein interacting module, of semaphorin 4E (Sema4E); Sema4E is expressed in the epithelial cells that line the pharyngeal arches in zebrafish. It may act as a guidance molecule to restrict the branchiomotor axons to the mesenchymal cells. Gain-of-function and loss-of-function studies demonstrate that Sema4E is essential for the guidance of facial axons from the hindbrain into their pharyngeal arch targets and is sufficient for guidance of gill motor axons. Sema4E guides facial motor axons by a repulsive action. Sema4E belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200521 [Multi-domain]  Cd Length: 456  Bit Score: 255.60  E-value: 3.96e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   50 FRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQA-VEWECDEATKKACYSKGKSKE-ECQNYIRVL-LVGGD 126
Cdd:cd11260     1 FKEQGIWNYSTMLLREDLGLLVLGAREAVFALDLNDISVKRAkVLWEVTEEKQKDCTNKGKHADiDCHNYIRILhKMNDS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  127 RLFTCGTNAFTPVCTNRSLSN--LTEIHDQISGMARCPYSPQHNSTALLTaGGELYAATAMDFPGRDPAIYRSLGIlpPL 204
Cdd:cd11260    81 RMYVCGTNAFSPTCDYISYDDgqLTLEGKQEDGKGKCPFDPFQRYSSVMV-DQDLYSATSMNFLGSEPVIMRSSPI--TI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  205 RTaQYNSKWLNEPNFVSSYDI----------GNFTYFFFRENAVEHDC-GKTVFSRAARVCKNDIGGRFLLEDTWTTFMK 273
Cdd:cd11260   158 RT-EFKSSWLNEPNFIYMAAVpesedspegdDDKIYLFFSETAVEYDFyNKLVVSRVARVCKGDLGGQRTLQKKWTSFLK 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  274 ARLNCSRP-GEVPFYyneLQSTFFLPELD----LIYGIFTTNVNSIAASAVCVFNLSAIAQAFS-GPFKYQ---ENSRSA 344
Cdd:cd11260   237 ARLDCSVPePSLPYV---IQDVFHVCHQDwrkcVFYAVFTSQSDSSQSSAVCAYNVTDISNVFSrGKFKTPvavETSFVK 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  345 W------LPYPNP----NPHFQCGTVDQGLyvNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGRE 414
Cdd:cd11260   314 WvmysgeLPVPRPgaciNNAARTSGIKKSL--NLPDKTLQFVKDKPLMDQAVHPITGKPLLVKRGALFTRIVVDMVTAAD 391

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578810013  415 ALVH-IIYLATDYGTIKKVrvpLNQTSSSCLLEEIELF-PErrrEPIRSLQIlhSQSVLFVGLREHVVKIPL 484
Cdd:cd11260   392 GQSYpVMFIGTANGYVLKA---VNYDGEMHIIEEVQLFePE---EPIDILRL--SQNQLYAGSASGVVQMPV 455
Sema_3C cd11251
The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C); Sema3C is a secreted ...
 52-487 6.09e-75

The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C); Sema3C is a secreted semaphorin expressed in and adjacent to cardiac neural crest cells, and causes impaired migration of neural crest cells to the developing cardiac outflow tract, resulting in the interruption of the aortic arch and persistent truncus arteriosus. It has been proposed that Sema3C acts as a guidance molecule, regulating migration of neural crest cells that express semaphorin receptors such as plexin A2. Sema3C may also participate in tumor progression. The cleavage of Sema3C induced by ADAMTS1 promotes the migration of breast cancer cells. Sema3C is a member of the class 3 semaphorin family of secreted proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200512 [Multi-domain]  Cd Length: 470  Bit Score: 255.59  E-value: 6.09e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   52 AKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSL-IQAVEWECDEATKKACYSKGKSKEE-CQNYIRVLL-VGGDRL 128
Cdd:cd11251     4 SERPLDYRILFMDEDQDRIYVGSKDHILSLNINNISQdALSIFWPASASKVEECKMAGKDPTHgCGNFVRVIQpYNRTHL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  129 FTCGTNAFTPVCT-----NRSLSNLTEIHDQI-SGMARCPYSPQHNSTALLTaGGELYAATAMDFPGRDPAIYRSLGILP 202
Cdd:cd11251    84 YVCGSGAFSPVCVyvnrgRRSEEQVFHIDSKAeSGKGRCSFNPNVNTVSVMI-NEELFSGMYIDFMGTDAAIFRSLTKRN 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  203 PLRTAQYNSKWLNEPNFVSSYDIGNFT-------YFFFRENAVEHD-CGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKA 274
Cdd:cd11251   163 AVRTDQHNSKWLSEPIFVDAHLIPDGTdpndaklYFFLKERLTDNSgSTKQIHSMIARVCPNDTGGQRSLVNKWTTFLKA 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  275 RLNCSRPGE--VPFYYNELQSTFFL----PELDLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPY 348
Cdd:cd11251   243 RLVCSVMDEdgTETHFDELEDVFLLetdnPRTTLVYGIFTTSSSVFKGSAVCVYHMSDIQTVFNGPFAHKEGPNHQLIAY 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  349 PNPNPHFQCGTVDQGLY---VNLTERNLQDAQKFI----LMHEVVQPVTTVPSFMEDNS--RFSHVAVDVVQGREALVHI 419
Cdd:cd11251   323 QGRIPYPRPGTCPGGAFtpnMQSTKEFPDDVVTFIrnhpLMFNPIYPIGRRPLLVRTGTdyKYTKIAVDRVNAADGRYHV 402

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  420 IYLATDYGTIKKVRV-PLNQTSSSCL-LEEIELFpeRRREPIRSLQILHSQSVLFVGLREHVVKIPLKRC 487
Cdd:cd11251   403 LFLGTDKGTVQKVVVlPTNGSLSGELiLEELEVF--KNHAPITNMKISSKKQQLYVSSEEGISQVSLHRC 470
Sema_4G cd11262
The Sema domain, a protein interacting module, of semaphorin 4G (Sema4G); The Sema4G and ...
 48-484 2.01e-74

The Sema domain, a protein interacting module, of semaphorin 4G (Sema4G); The Sema4G and Sema4C genes are expressed in the developing cerebellar cortex. Sema4G and Sema4C proteins specifically bind to Plexin B2 expressed in the cerebellar granule cells. Sema4G and Sema4C are involved in neural tube closure and cerebellar granule cell development through Plexin B2.Sema4G belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200523 [Multi-domain]  Cd Length: 457  Bit Score: 253.53  E-value: 2.01e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   48 REFRAkNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLS--LIQAVEWECDEATKKACYSKGK-SKEECQNYIRVLL-V 123
Cdd:cd11262     1 RRFRG-PAQNYSTLLLEDESGRLYVGARGAIFSLNASDISdsSALTIDWEASPEQKHQCLKKGKnNQTECFNHVRFLQrF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  124 GGDRLFTCGTNAFTPVCT-----NRSLSNLTEihdqiSGMARCPYSPQHNSTALLTaGGELYAATAMDFpgRD-PAIYRS 197
Cdd:cd11262    80 NSTHLYTCGTHAFRPLCAyidaeRFTLSSQFE-----EGKEKCPYDPAKGYTGLIV-DGQLYTASQYEF--RSfPDIRRN 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  198 LGiLPPLRTAQYNSKWLNEPNFVSSY----DIGNFT------YFFFRENAVEHDC--GKTVFSRAARVCKNDIGGRFLLE 265
Cdd:cd11262   152 SP-QPTLRTEEAPTRWLNDADFVGSVlvreSMNSSVgdddkiYFFFTERSQEETAyfSQSRVARVARVCKGDRGGKKTLQ 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  266 DTWTTFMKARLNCSRPgEVPFYYNELQSTFFL----PELDLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENS 341
Cdd:cd11262   231 RKWTSFLKARLVCYIP-EYEFLFNVLRSVFVLwgstPQDTVFYGIFGLEWKNVKASAICRYSLSDIQTAFEGPYMEYQDS 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  342 RSAWLPY----PNPNPHfQCGTVD---QGLYvnlTERNLQD-----AQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDV 409
Cdd:cd11262   310 SSKWSRYtgkvPEPRPG-SCITDEhrsQGIN---SSQDLPDnvldfVRRHPLMAEQVLPVEGRPLLFKRNVIYTKIAVQT 385

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578810013  410 VQGREALV-HIIYLATDYGTIKKvrvPLNQTSSSCLLEEIELFpeRRREPIRSLQILHSQSVLFVGLREHVVKIPL 484
Cdd:cd11262   386 VRGLDGRVyDVLFLGTDEGWLHK---AVVIGSAVHIIEELQVF--REPQPVENLVISKKQNSLYVGARSGVVQVPL 456
Sema_4D cd11259
The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); ...
 47-484 8.33e-72

The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); Sema4D/CD100 is expressed in immune cells and plays critical roles in immune response; it is thus termed an "immune semaphorin". It is expressed by lymphocytes and promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. Sema4D/CD100 knock-out mice demonstrate that Sema4D is required for normal activation of B and T lymphocytes. Sema4D increases B-cell and DC function using either Plexin B1 or CD72 as receptors. The function of Sema4D in immune response implicates its role in infectious and noninfectious diseases. Sema4D belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200520 [Multi-domain]  Cd Length: 471  Bit Score: 246.69  E-value: 8.33e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   47 LREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQ-AVEWECDEATKKACYSKGKSKE-ECQNYIRVLLVG 124
Cdd:cd11259     9 LVHFHEPDVSNYSTLLLSEDKDVLYVGAREAVFALNALNISEKQhELYWKVSEDKRTKCAVKGKSKQtECRNYIRVLQPL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  125 GDR-LFTCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLTaGGELYAATAMDFPGRDPAIYRSLGiLPP 203
Cdd:cd11259    89 NDTfLYVCGTNAFQPTCDYLNLTSFRLLGKNEDGKGRCPFDPAQSYTSVMV-DGELYSGTSYNFLGSEPIISRNSS-QSP 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  204 LRTaQYNSKWLNEPNFVSSYDI----------GNFTYFFFRENAVEHD-CGKTVFSRAARVCKNDIGGRFLLEDTWTTFM 272
Cdd:cd11259   167 LRT-EYAIPWLNEPSFVFADVIradpdspdgeDDKIYFFFTEVSVEYEfVGKLLIPRIARVCKGDQGGLRTLQKKWTSFL 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  273 KARLNCSRPgEVPFYYNELQSTFFLPELDL----IYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPfKYQ-----ENSRS 343
Cdd:cd11259   246 KARLICSIP-DKNLVFNVVNDVFILKSPTLkepvIYGVFTPQLNNVGLSAVCAYNLSTVEEVFSKG-KYMqsatvEQSHT 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  344 AWLPY----PNPNPHFQCGTVDQGL----YVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREA 415
Cdd:cd11259   324 KWVRYngevPKPRPGACINNEARAAnytsSLNLPDKTLQFVKDHPLMDDSVTPIGNRPRLIKKDVNYTQIVVDRVQALDG 403

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578810013  416 LVH-IIYLATDYGTIKKVrvpLNQTSSSCLLEEIELFPErrREPIRSLQILHSQS--VLFVGLREHVVKIPL 484
Cdd:cd11259   404 TIYdVMFISTDRGALHKA---ISLENEVHIIEETQLFPD--FEPVQTLLLSSKKGrrFLYAGSNSGVVQSPL 470
Sema_3G cd11255
The Sema domain, a protein interacting module, of semaphorin 3G (Sema3G); Semaphorin 3G is ...
 56-487 2.54e-68

The Sema domain, a protein interacting module, of semaphorin 3G (Sema3G); Semaphorin 3G is identified as a primarily endothelial cell- expressed class 3 semaphorin that controls endothelial and smooth muscle cell functions in autocrine and paracrine manners, respectively. It is mainly expressed in the lung and kidney, and a little in the brain. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200516 [Multi-domain]  Cd Length: 474  Bit Score: 237.12  E-value: 2.54e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   56 VDFSQLTFDPGQKELVVGARNYLFRLQLEDLSL-IQAVEWECDEATKKACYSKGKSKE-ECQNYIRVLL-VGGDRLFTCG 132
Cdd:cd11255     8 LHLSAVYLDEYRDRLFLGGKDVLYSLRLDQTHPdAKEIHWPPLPGQREECIRKGKDPEtECANFVRVLQpFNRTHLLACG 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  133 TNAFTPVCTNRSLSNLTEiH----DQI---SGMARCPYSPQHNSTALLTaGGELYAATAMDFPGRDPAIYRSLGILPPLR 205
Cdd:cd11255    88 TGAFQPVCALINVGHRGE-HvfslDPTtveSGRGRCPHEPKRPFASTFT-GGELYTGLTADFLGRDSVIFRGFGTRSPLR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  206 TaQYNSKWLNEPNFVSSYDI-------GNFTYFFFRENAVEHDCGK--TVFSRAARVCKNDIGGRFLLEDTWTTFMKARL 276
Cdd:cd11255   166 T-ETDQRLLHEPRFVAAHLIpdnadrdNDKVYFFFTERATETAEDDdgAIHSRVGRLCANDAGGQRVLVNKWSTFIKARL 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  277 NCSRPGE--VPFYYNELQSTFFL-------PEldlIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLP 347
Cdd:cd11255   245 VCSVPGPhgIQTHFDQLEDVFLLrtkdgksPE---IYALFSTISNVFQGFAVCVYSMADIWEVFNGPFAHKDGPDHQWGP 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  348 Y----PNPNPHFqC--GTVDQ-----GLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNS--RFSHVAVDVVQGRE 414
Cdd:cd11255   322 YegkvPYPRPGV-CpsKITAQpgrafRSTKDYPDEVLQFARAHPLMWRPVYPSHRRPVLVKTGLpyRLTQIVVDRVEAED 400

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578810013  415 ALVHIIYLATDYGTIKKVrVPLNQTSSS----CLLEEIELFpeRRREPIRSLQILHSQSVLFVGLREHVVKIPLKRC 487
Cdd:cd11255   401 GYYDVMFIGTDSGSVLKV-IVLQKGNSAageeVTLEELQVF--KVPTPITEMEISVKRQMLYVGSRTGVAQVPLHRC 474
Sema_4F cd11261
The Sema domain, a protein interacting module, of semaphorin 4F (Sema4F); Sema4F plays role in ...
 45-483 1.09e-67

The Sema domain, a protein interacting module, of semaphorin 4F (Sema4F); Sema4F plays role in heterotypic cell-cell contacts and controls cell proliferation and suppresses tumorigenesis. In neurofibromatosis type 1 (NF1) patients, reduced Sema4F level disrupts Schwann cell/axonal interactions. Experiments using a yeast two-hybrid system show that the extreme C-terminus of Sema4F interacts with the PDZ domains of post-synaptic density protein SAP90/PSD-95, indicating possible functional involvement of Semas4F at glutamatergic synapses. Recent work also suggests a role for Sema4F in the injury response of intramedullary axotomized motoneuron. Sema4F belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulator molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200522 [Multi-domain]  Cd Length: 460  Bit Score: 234.78  E-value: 1.09e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   45 PWLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLS-LIQAVEWECDEATKKACYSKGKSKEECQNYIRVL-L 122
Cdd:cd11261     1 SALTRFSAPHTYNYSVLLVDPASHTLYVGARDAIFALTLPFSGeRPRRIDWMVPEAHRQNCRKKGKKEAECHNFIRILaI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  123 VGGDRLFTCGTNAFTPVCTNRSLSNLTEIHDQISGMARCPYSPQHNSTALLtAGGELYAATAMDFPGRDPAIYRSLGILP 202
Cdd:cd11261    81 ANASHLLTCGTFAFDPKCGVIDVSSFQQVERLESGRGKCPFEPAQRSAAIM-AGGVLYAATVKNFLGTEPIISRAVGRAE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  203 PLRTAQYNSKWLNEPNFVSSY----------DIGNFTYFFFRENAVEHDCGKTV-FSRAARVCKNDIGGRFLLEDTWTTF 271
Cdd:cd11261   160 EWIRTETLPSWLNAPAFVAAVflspaewgdeDGDDEIYFFFTETAREYDSYERIkVPRVARVCAGDLGGRKTLQQRWTTF 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  272 MKARLNCSRP--GEVpfyYNELQSTFFLPELD-----LIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSA 344
Cdd:cd11261   240 LKADLLCPGPehGRA---SSILQDVTTLRPLPgagtpIFYGIFSSQWEGASISAVCAFRPQDIRRVMNGPFREFKHDCNR 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  345 WLPY-----PNPNPHfQCGTVDQ-----GLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVA---VDVVQ 411
Cdd:cd11261   317 GLPVmdsdvPQPRPG-ECITNNMkllgfGSSLSLPDRVLTFVRDHPLMDRPVFPADGHPLLVTTDTAYLRVAahrVTSLS 395

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578810013  412 GREalVHIIYLATDYGTIKK-VRVplnqTSSSCLLEEIELFPErrREPIRSLQILHSQsvLFVGLREHVVKIP 483
Cdd:cd11261   396 GKE--YDVLYLGTEDGHLHRaVRI----GAQLSVLEDLALFPE--PQPVENLQLHHNW--LLVGSDTEVTQIN 458
Sema cd09295
The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins ...
 57-484 4.94e-58

The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins and plexins have a Sema domain on their N-termini. Plexins function as receptors for the semaphorins. Evolutionarily, plexins may be the ancestor of semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems, and cancer. Semaphorins can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. Plexins are a large family of transmembrane proteins, which are divided into four types (A-D) according to sequence similarity. In vertebrates, type A plexins serve as co-receptors for neuropilins to mediate the signalling of class 3 semaphorins. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B plexins. This family also includes the MET and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves to recognize and bind receptors.


Pssm-ID: 200495 [Multi-domain]  Cd Length: 392  Bit Score: 205.52  E-value: 4.94e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   57 DFSQLTFDPGQKELVVGARNYLFRLQL----EDLSLIQ-AVEWECDEATKKACYSKGKSKEECQNYIRVLLVGG--DRLF 129
Cdd:cd09295     1 DDDKILVSFRKDTIYVGAIARIYKVDGggtrLLLSCISpELNFGFNEDQKAFCPLRRGKWTECINYIKVLQQKGdlDILA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  130 TCGTNAFTPVCTNRSLsNLTEIHDQI---SGMARCPYSPQHNSTALLTAGgELYAATAMDF-PGRDPAIYRSLGILPPLR 205
Cdd:cd09295    81 VCGSNAAQPSCGSYRL-DVLVELGKVrwpSGRPRCPIDNKHSNMGVNVDS-KLYSATDHDFkDGDRPALSRRSSNVHYLR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  206 TAQYNSKWLNEPNFVSSYDIG---NFTYFFFRENAVEHDC-GKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRP 281
Cdd:cd09295   159 IVVDSSTGLDEITFVYAFVSGdddDEVYFFFRQEPVEYLKkGMVYVPRIARVCKLDVGGCHRLKKKLTSFLKADLNCSRP 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  282 GEvPFYYNELQSTFFL---PELDLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENsrsawlpYPnpnphfqcg 358
Cdd:cd09295   239 QS-GFAFNLLQDATGDtknLIQDVKFAIFSSCLNKSVESAVCAYLFTDINNVFDDPVEAINN-------RP--------- 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  359 tvdqgLYVNLTERnlqdaqkfilmhevvqpvttvpsfmednSRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVpLNQ 438
Cdd:cd09295   302 -----LYAHQNQR----------------------------SRLTSIAVDATKQKSVGYQVVFLGLKLGSLGKALA-FFF 347

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 578810013  439 TSSSCLLEEIELFpeRRREPIRSLQILHSQSVLFVGLREHVVKIPL 484
Cdd:cd09295   348 LYKGHIIEEWKVF--KDSSRITNLDLSRPPLYLYVGSESGVLGVPV 391
Sema_7A cd11243
The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108); ...
 64-484 1.12e-51

The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108); Sema7A plays regulatory roles in both immune and nervous systems. Unlike other semaphorins, which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Sema7A also plays a critical role in the negative regulation of T cell activation and function. Sema7A is a membrane-anchored member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200504 [Multi-domain]  Cd Length: 414  Bit Score: 187.75  E-value: 1.12e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   64 DPGQKELVVGARNYLFRLQLEDLSLIQavEWECDEATKKACYSKGkSKEECQNYIRVLLVGGDRLFTCGTNAFTPVCTNr 143
Cdd:cd11243    10 EAGSSSVYVGGQGALYLLDFTGSAVIV--KKIPDEKTEKDCKKRA-TLDDCENYITLIKKLDYRLLVCGTNAGSPKCWF- 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  144 sLSNLTEIHDQiSGMARCPYSPQHNStALLTAGGELYAATAmdfpGRDPAI--YRSLGILPPLRTAqynSKWLNEPNFVS 221
Cdd:cd11243    86 -LVNQTLVTLS-ADRGVAPFLPDENS-LVLIEGNNVYSTIS----GKKGNIprFRRYGGKKELYTS---DTVMQKPQFVK 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  222 S--------YDigNFTYFFFREN--AVEHDCGKTVfSRAARVCKNDIGGRFLLE-DTWTTFMKARLNCSRPGEvPFYYNE 290
Cdd:cd11243   156 AtllpedeqYQ--DKIYYFFREDneDKGPEAEPNI-SRVARLCKEDQGGTSSLStSKWSTFLKARLVCGDPAT-PMNFNR 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  291 LQSTFFLP----ELDLIYGIFTTNVNSiaaSAVCVFNLSAIAQAFSgpfkyqenSRSAW-LPYPNPNPH-FQCGTVDQgl 364
Cdd:cd11243   232 LQDVFLLPkeewREAVVYGVFSNTWGS---SAVCSYSLGDIDKVFR--------TSSLKgYSGSLPNPRpGTCVPPEQ-- 298

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  365 yvNLTERNLQDAQKFILMHEVVQPVTTVPSFM-EDNSRFSHVAVDVVQGREAL-VHIIYLATDYGTIKKVRVPLNQTSSs 442
Cdd:cd11243   299 --THPSETFSFADEHPELDDRIEPDEPRKLPVfQNKDHYQKVVVDEVRASDGVsYDVLYLATDKGKIHKVVESKGQTHN- 375

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 578810013  443 clLEEIELFpeRRREPIRSLQILHSQSVLFVGLREHVVKIPL 484
Cdd:cd11243   376 --IMEIQPF--KEQEPIQSMILDAERSHLYVGTKAEVTRLPL 413
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
 291-466 1.84e-51

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 179.00  E-value: 1.84e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   291 LQSTFFLPEL------DLIYGIFTTN-VNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLPYPNPNPHFQCGT-VDQ 362
Cdd:pfam01403    1 LQDVFVLKPGagdaldTVLYGVFTTQwSNSIGGSAVCAFSLSDINAVFEGPFKEQEKSDSKWLPYTGKVPYPRPGTcIND 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   363 GLYVNLTERNLQDAQKFILMHEVVQPVTTVPSFMEDNSRFSHVAVDVVQGREALVHIIYLATDYGTIKKVRVPLNQTssS 442
Cdd:pfam01403   81 PLRLDLPDSVLNFVKDHPLMDEAVQPVGGRPLLVRTGVRLTSIAVDRVQALDGNYTVLFLGTDDGRLHKVVLVGSEE--S 158

                          170       180
                   ....*....|....*....|....
gi 578810013   443 CLLEEIELFPErrREPIRSLQILH 466
Cdd:pfam01403  159 HIIEEIQVFPE--PQPVLNLLLSS 180
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 844-896 2.61e-17

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 76.47  E-value: 2.61e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 578810013    844 WSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPCP 896
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 598-651 7.78e-16

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 72.62  E-value: 7.78e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 578810013    598 WTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHlLCP 651
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQ-PCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 787-839 1.85e-15

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 71.46  E-value: 1.85e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 578810013    787 WSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQECNILPCP 839
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
Sema_plexin_like cd11236
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine ...
 61-331 1.74e-12

The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestor of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signalling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. This family also includes the Met and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200497 [Multi-domain]  Cd Length: 401  Bit Score: 70.44  E-value: 1.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   61 LTFDPGQKELVVGARNYLFRLQlEDLSLIQAVE-------WECdeaTKKACYSKGKSKEECQNYIRVLLV--GGDRLFTC 131
Cdd:cd11236     5 LAVDNSTGRVYVGAVNRLYQLD-SSLLLEAEVStgpvldsPLC---LPPGCCSCDHPRSPTDNYNKILLIdySSGRLITC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  132 GTnAFTPVCTNRSLSNLTEIHdQISGMARCPYSPQHNSTALLTAGGE-----LYAATAMD---FPGRDPAI-YRSLGILP 202
Cdd:cd11236    81 GS-LYQGVCQLRNLSNISVVV-ERSSTPVAANDPNASTVGFVGPGPYnnenvLYVGATYTnngYRDYRPAVsSRSLPPDD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  203 PLRTAQYN--SKWLNEPNFVSSYDI--------GNFTYFFFRENAVeHDCGKTVFSRAARVCKNDIGgrflledtWTTFM 272
Cdd:cd11236   159 DFNAGSLTggSAISIDDEYRDRYSIkyvygfssGGFSYFVTVQRKS-VDDESPYISRLVRVCQSDSN--------YYSYT 229

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578810013  273 KARLNC-SRPGEVpfyYNELQSTF-------------FLPELDLIYGIFTTNVNSIAA----SAVCVFNLSAIAQAF 331
Cdd:cd11236   230 EVPLQCtGGDGTN---YNLLQAAYvgkagsdlarslgISTDDDVLFGVFSKSKGPSAEpsskSALCVFSMKDIEAAF 303
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 656-702 1.13e-11

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 60.68  E-value: 1.13e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 578810013    656 WTGWGPWERCTAQCGGGIQARRRICENGP------DCAGCNVEYQSCNTNPCP 702
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPpqngggPCTGEDVETRACNEQPCP 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 599-647 1.50e-09

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 54.59  E-value: 1.50e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578810013   599 TPWTSWSPCSTTCGIGFQVRQRSCSNPtPRHGGRVCvGQNREERYCNEH 647
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLP 50
TSP_1 pfam00090
Thrombospondin type 1 domain;
845-895 2.53e-09

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 53.96  E-value: 2.53e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 578810013   845 SCWSPWTKCSATCGGGHYMRTRSCSNPAPayGGDICLGLHTEEALCNTQPC 895
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
599-645 5.37e-09

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 52.81  E-value: 5.37e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 578810013   599 TPWTSWSPCSTTCGIGFQVRQRSCSNPTPrhGGRVCVGQNREERYCN 645
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACK 45
TSP_1 pfam00090
Thrombospondin type 1 domain;
788-838 6.16e-09

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 52.81  E-value: 6.16e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 578810013   788 SAWTSWSQCSRDCSRGIRNRKRVCNNPEPkyGGMPCLGPSLEYQECNILPC 838
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
Sema_plexin_A2 cd11272
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor ...
 58-514 2.08e-08

The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200533 [Multi-domain]  Cd Length: 515  Bit Score: 58.02  E-value: 2.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013   58 FSQLTFDPGQKELVVGARNYLFRLQlEDLSLIQAVEwECDEATKKACYSK------GKSKEECQNYIRVLLV--GGDRLF 129
Cdd:cd11272    13 FNHLTVHQSTGAVYVGAINRVYKLS-GNLTILVAHK-TGPEEDNKSCYPPlivqpcSEVLTLTNNVNKLLIIdySENRLL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  130 TCGTnAFTPVCTNRSLSNLTEIHDqiSGMARCPYSPQHNSTALL------TAG--GELYAATAMD-----FPG------- 189
Cdd:cd11272    91 ACGS-LYQGVCKLLRLDDLFILVE--PSHKKEHYLSSVNKTGTMygvivrSEGedGKLFIGTAVDgkqdyFPTlssrklp 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  190 RDPaiyRSLGILPPLRTAQYNSKWLNEPN----FVSSYDI--------GNFTYFFF-----RENAVEHDCGKTVF-SRAA 251
Cdd:cd11272   168 RDP---ESSAMLDYELHSDFVSSLIKIPSdtlaLVSHFDIfyiygfasGNFVYFLTvqpetPEGVSINSAGDLFYtSRIV 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  252 RVCKNDiggrflleDTWTTFMKARLNCSRPGEvpfYYNELQSTFF-------------LPELDLIYGIFTTNVNSIAA-- 316
Cdd:cd11272   245 RLCKDD--------PKFHSYVSLPFGCVRGGV---EYRLLQAAYLskpgevlarslniTAQEDVLFAIFSKGQKQYHHpp 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  317 --SAVCVFNLSA----IAQAFSGPFKYQENSRSAWL----------PYPnPNPHFqCG-TVDQGLYVNlternlqdaqkf 379
Cdd:cd11272   314 ddSALCAFPIRAinaqIKERLQSCYQGEGNLELNWLlgkdvqctkaPVP-IDDNF-CGlDINQPLGGS------------ 379

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578810013  380 ilmhevvQPVTTVPSFMEDNSRFSHVAVDVVQGREalvhIIYLATDYGTIKKVRV--PLNqtsSSCLLEEIELFpeRRRE 457
Cdd:cd11272   380 -------TPVEGVTLYTSSRDRLTSVASYVYNGYS----VVFVGTKSGKLKKIRAdgPPH---GGVQYEMVSVF--KDGS 443

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 578810013  458 PI-RSLQILHSQSVLFVGLREHVVKIPLKRCQFYRTRSTCIGAQDPYCGWDVVMKKCT 514
Cdd:cd11272   444 PIlRDMAFSIDHKYLYVMSERQVSRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCS 501
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 486-533 2.53e-08

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 51.17  E-value: 2.53e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 578810013   486 RCQFYRTRSTCIGAQDPYCGWDVVMKKCTS----LEESLSMTQWEQSISACP 533
Cdd:pfam01437    1 RCSQYTSCSSCLAARDPYCGWCSSEGRCVRrsacGAPEGNCEEWEQASSKCP 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 544-595 7.15e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 49.89  E-value: 7.15e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 578810013    544 GVWSPWTPCTHTDGSAVgscLCRTRSCDSPAPQCGGWQCEGPGMEIANCSRN 595
Cdd:smart00209    2 SEWSEWSPCSVTCGGGV---QTRTRSCCSPPPQNGGGPCTGEDVETRACNEQ 50
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 847-895 2.85e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 48.04  E-value: 2.85e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578810013   847 WSPWTKCSATCGGGHYMRTRSCSNPaPAYGGDIClGLHTEEALCNTQPC 895
Cdd:pfam19028    6 WSEWSECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 899-940 8.38e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 46.81  E-value: 8.38e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 578810013    899 WSEWSDWSECEAS---GVQVRARQCIL--LFPMGSQCSGNTTESRPC 940
Cdd:smart00209    1 WSEWSEWSPCSVTcggGVQTRTRSCCSppPQNGGGPCTGEDVETRAC 47
TSP_1 pfam00090
Thrombospondin type 1 domain;
900-943 8.60e-07

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 46.64  E-value: 8.60e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 578810013   900 SEWSDWSECEAS---GVQVRARQCILLFPMGSQCSGNTTESRPCVFD 943
Cdd:pfam00090    1 SPWSPWSPCSVTcgkGIQVRQRTCKSPFPGGEPCTGDDIETQACKMD 47
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 788-838 1.24e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 46.12  E-value: 1.24e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 578810013   788 SAWTSWSQCSRDCSRGIRNRKR---VcnnpEPKYGGMPClGPSLEYQECNILPC 838
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRtviV----EPQNGGRPC-PELLERRPCNLPPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
659-701 3.64e-06

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 44.72  E-value: 3.64e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 578810013   659 WGPWERCTAQCGGGIQARRRIC----ENGPDCAGCNVEYQSCNTNPC 701
Cdd:pfam00090    3 WSPWSPCSVTCGKGIQVRQRTCkspfPGGEPCTGDDIETQACKMDKC 49
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
486-524 1.21e-05

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 43.30  E-value: 1.21e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 578810013    486 RCQFYRTRSTCIGAQDPYCGWDVVMKKCTSLEESLSMTQ 524
Cdd:smart00423    1 RCSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQ 39
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 602-647 1.80e-05

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 43.21  E-value: 1.80e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 578810013   602 TSWSPCSTTCGIGFQVRQRSCSNPTPR--HGGRVCVGQNR--EERYCNEH 647
Cdd:pfam19030    4 GPWGECSVTCGGGVQTRLVQCVQKGGGsiVPDSECSAQKKppETQSCNLK 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 900-940 1.05e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 40.73  E-value: 1.05e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 578810013   900 SEWSDWSECEAS---GVQVRARQcILLFPM--GSQCsGNTTESRPC 940
Cdd:pfam19028    4 SEWSEWSECSVTcggGVQTRTRT-VIVEPQngGRPC-PELLERRPC 47
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 899-941 8.73e-04

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 43.01  E-value: 8.73e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 578810013  899 WSEWSDWSEC-----EASGVQVRARQCIllFPMGSQCSGNTTESRPCV 941
Cdd:PTZ00087  233 YTEWGEWSNCsmecdHPDNVQIRERKCA--HPSGDCFKGDLKETRPCQ 278
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 657-701 2.25e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 37.26  E-value: 2.25e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 578810013   657 TGWGPWERCTAQCGGGIQARRRIC-----ENGPDCAGcNVEYQSCNTNPC 701
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVivepqNGGRPCPE-LLERRPCNLPPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
544-593 2.92e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 36.63  E-value: 2.92e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 578810013   544 GVWSPWTPCTHTDGSAVGSclcRTRSCDSPAPqcGGWQCEGPGMEIANCS 593
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQV---RQRTCKSPFP--GGEPCTGDDIETQACK 45
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 849-895 3.03e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 37.05  E-value: 3.03e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 578810013   849 PWTKCSATCGGGhyMRTRS--CSNPAP--AYGGDICLGLH--TEEALCNTQPC 895
Cdd:pfam19030    5 PWGECSVTCGGG--VQTRLvqCVQKGGgsIVPDSECSAQKkpPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 660-701 6.61e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 35.89  E-value: 6.61e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 578810013   660 GPWERCTAQCGGGIQARRRIC--------ENGPDCAGCN--VEYQSCNTNPC 701
Cdd:pfam19030    4 GPWGECSVTCGGGVQTRLVQCvqkgggsiVPDSECSAQKkpPETQSCNLKPC 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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