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Conserved domains on  [gi|578809447|ref|XP_006714399|]
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tetratricopeptide repeat protein 29 isoform X4 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 197-408 6.66e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 65.91  E-value: 6.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 197 QLIKIDcgKKEAEAHMHMGLLYEEDGQLLEAAEHYEAFHQLTQGRiwkdetgrslnllaceslLRTYRLLSDKMLENKEY 276
Cdd:COG2956   33 EALELD--PETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDR------------------AEALLELAQDYLKAGLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 277 KQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDdlslgrGYEAIAKVLQSQGEM 356
Cdd:COG2956   93 DRAEELLEKLLELDPD------DAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAH------AYCELAELYLEQGDY 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578809447 357 TEAIKYLKKFVKIARNNfqsldlVRASTMLGDIYNEKGYYNKASECFQQAFD 408
Cdd:COG2956  161 DEAIEALEKALKLDPDC------ARALLLLAELYLEQGDYEEAIAALERALE 206
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 197-408 6.66e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 65.91  E-value: 6.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 197 QLIKIDcgKKEAEAHMHMGLLYEEDGQLLEAAEHYEAFHQLTQGRiwkdetgrslnllaceslLRTYRLLSDKMLENKEY 276
Cdd:COG2956   33 EALELD--PETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDR------------------AEALLELAQDYLKAGLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 277 KQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDdlslgrGYEAIAKVLQSQGEM 356
Cdd:COG2956   93 DRAEELLEKLLELDPD------DAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAH------AYCELAELYLEQGDY 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578809447 357 TEAIKYLKKFVKIARNNfqsldlVRASTMLGDIYNEKGYYNKASECFQQAFD 408
Cdd:COG2956  161 DEAIEALEKALKLDPDC------ARALLLLAELYLEQGDYEEAIAALERALE 206
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 224-420 1.83e-05

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 46.73  E-value: 1.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 224 LLEAAEhyEAFHQLTQGRIWKDEtgrslnllACESLLRTYRllsdkmlENKEYKQAIKIlikASEIAKEGsDKKMEAEas 303
Cdd:PRK11788 122 LLDRAE--ELFLQLVDEGDFAEG--------ALQQLLEIYQ-------QEKDWQKAIDV---AERLEKLG-GDSLRVE-- 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 304 yylgLAHLaaeeyetaltvldtYCKISTdldddlslgrgyEAIAkvlqsQGEMTEAIKYLKKFVKIARNNfqsldlVRAS 383
Cdd:PRK11788 179 ----IAHF--------------YCELAQ------------QALA-----RGDLDAARALLKKALAADPQC------VRAS 217

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 578809447 384 TMLGDIYNEKGYYNKASECFQQAFDTTVELMSM---PLMD 420
Cdd:PRK11788 218 ILLGDLALAQGDYAAAIEALERVEEQDPEYLSEvlpKLME 257
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 236-406 3.69e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.62  E-value: 3.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447  236 QLTQGRIWKDET--GRSLNLLACESLLRTyrLLSDKMLENKEYKQAIKILIKASEIAKEGSDKKMEaeasyyLGLAHLAA 313
Cdd:TIGR02917 339 QLRLGRVDEAIAtlSPALGLDPDDPAALS--LLGEAYLALGDFEKAAEYLAKATELDPENAAARTQ------LGISKLSQ 410

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447  314 EEYETALTVLDTyckiSTDLDDDlsLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSLDLvrastmLGDIYNEK 393
Cdd:TIGR02917 411 GDPSEAIADLET----AAQLDPE--LGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNL------LGAIYLGK 478

                         170
                  ....*....|...
gi 578809447  394 GYYNKASECFQQA 406
Cdd:TIGR02917 479 GDLAKAREAFEKA 491
TPR_12 pfam13424
Tetratricopeptide repeat;
343-408 9.41e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.14  E-value: 9.41e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578809447  343 YEAIAKVLQSQGEMTEAIKYLKKFVKIARNNF--QSLDLVRASTMLGDIYNEKGYYNKASECFQQAFD 408
Cdd:pfam13424   6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLgpDHPLTATTLLNLGRLYLELGRYEEALELLERALA 73
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 197-408 6.66e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 65.91  E-value: 6.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 197 QLIKIDcgKKEAEAHMHMGLLYEEDGQLLEAAEHYEAFHQLTQGRiwkdetgrslnllaceslLRTYRLLSDKMLENKEY 276
Cdd:COG2956   33 EALELD--PETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDR------------------AEALLELAQDYLKAGLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 277 KQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDdlslgrGYEAIAKVLQSQGEM 356
Cdd:COG2956   93 DRAEELLEKLLELDPD------DAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAH------AYCELAELYLEQGDY 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578809447 357 TEAIKYLKKFVKIARNNfqsldlVRASTMLGDIYNEKGYYNKASECFQQAFD 408
Cdd:COG2956  161 DEAIEALEKALKLDPDC------ARALLLLAELYLEQGDYEEAIAALERALE 206
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 197-410 4.51e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 63.59  E-value: 4.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 197 QLIKIDcgKKEAEAHMHMGLLYEEDGQLLEAAEHYEAFHQLtqgriwkdetgRSLNLLACESLLRTYrllsdkmLENKEY 276
Cdd:COG2956   67 KLLERD--PDRAEALLELAQDYLKAGLLDRAEELLEKLLEL-----------DPDDAEALRLLAEIY-------EQEGDW 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 277 KQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYckistdLDDDLSLGRGYEAIAKVLQSQGEM 356
Cdd:COG2956  127 EKAIEVLERLLKLGPE------NAHAYCELAELYLEQGDYDEAIEALEKA------LKLDPDCARALLLLAELYLEQGDY 194

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 578809447 357 TEAIKYLKKFVKIARNNFQSLDlvrastMLGDIYNEKGYYNKASECFQQAFDTT 410
Cdd:COG2956  195 EEAIAALERALEQDPDYLPALP------RLAELYEKLGDPEEALELLRKALELD 242
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 207-408 7.59e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 61.16  E-value: 7.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 207 EAEAHMHMGLLYEEDGQLLEAAEHYEAFHQLTQGRIWKDETGRSLNLLACESLLRTYRLLsdkmlENKEYKQAIKILIKA 286
Cdd:COG3914   30 AELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQ-----ALGRYEEALALYRRA 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 287 SEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLdddlslGRGYEAIAKVLQSQGEMTEAIKYLKKF 366
Cdd:COG3914  105 LALNPD------NAEALFNLGNLLLALGRLEEALAALRRALALNPDF------AEAYLNLGEALRRLGRLEEAIAALRRA 172

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 578809447 367 VKIARNNfqsldlVRASTMLGDIYNEKGYYNKASECFQQAFD 408
Cdd:COG3914  173 LELDPDN------AEALNNLGNALQDLGRLEEAIAAYRRALE 208
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
206-406 3.16e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 57.32  E-value: 3.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 206 KEAEAHMHMGLLYEEDGQLLEAAEHYEAFHQLtqgriwKDETGRSLNLLAcesllRTYRLLsdkmlenKEYKQAIKILIK 285
Cdd:COG0457    6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALEL------DPDDAEALYNLG-----LAYLRL-------GRYEEALADYEQ 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 286 ASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTyckiSTDLDDDLSlgRGYEAIAKVLQSQGEMTEAIKYLKK 365
Cdd:COG0457   68 ALELDPD------DAEALNNLGLALQALGRYEEALEDYDK----ALELDPDDA--EALYNLGLALLELGRYDEAIEAYER 135

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 578809447 366 FVKIARNNFQSLDLvrastmLGDIYNEKGYYNKASECFQQA 406
Cdd:COG0457  136 ALELDPDDADALYN------LGIALEKLGRYEEALELLEKL 170
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 190-406 8.89e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 56.66  E-value: 8.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 190 ERCFKiaQLIKIDcgKKEAEAHMHMGLLYEEDGQLLEAAEHYEAFHQLTQGRIwkdetgrslnllacesllRTYRLLSDK 269
Cdd:COG2956   96 EELLE--KLLELD--PDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENA------------------HAYCELAEL 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 270 MLENKEYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYckistdLDDDLSLGRGYEAIAKV 349
Cdd:COG2956  154 YLEQGDYDEAIEALEKALKLDPD------CARALLLLAELYLEQGDYEEAIAALERA------LEQDPDYLPALPRLAEL 221

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 578809447 350 LQSQGEMTEAIKYLKKFVKIARNNFQSLdlvrastMLGDIYNEKGYYNKASECFQQA 406
Cdd:COG2956  222 YEKLGDPEEALELLRKALELDPSDDLLL-------ALADLLERKEGLEAALALLERQ 271
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 271-406 3.80e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 54.74  E-value: 3.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 271 LENKEYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYckistdLDDDLSLGRGYEAIAKVL 350
Cdd:COG2956   19 LLNGQPDKAIDLLEEALELDPE------TVEAHLALGNLYRRRGEYDRAIRIHQKL------LERDPDRAEALLELAQDY 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 578809447 351 QSQGEMTEAIKYLKKFVKIARNNFQSLdlvrasTMLGDIYNEKGYYNKASECFQQA 406
Cdd:COG2956   87 LKAGLLDRAEELLEKLLELDPDDAEAL------RLLAEIYEQEGDWEKAIEVLERL 136
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 300-408 5.50e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.95  E-value: 5.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 300 AEASYYLGLAHLAAEEYETALTVLDTYckistdLDDDLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQsldl 379
Cdd:COG4783    4 AEALYALAQALLLAGDYDEAEALLEKA------LELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPE---- 73

                         90       100
                 ....*....|....*....|....*....
gi 578809447 380 vrASTMLGDIYNEKGYYNKASECFQQAFD 408
Cdd:COG4783   74 --ARLNLGLALLKAGDYDEALALLEKALK 100
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 224-420 1.83e-05

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 46.73  E-value: 1.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 224 LLEAAEhyEAFHQLTQGRIWKDEtgrslnllACESLLRTYRllsdkmlENKEYKQAIKIlikASEIAKEGsDKKMEAEas 303
Cdd:PRK11788 122 LLDRAE--ELFLQLVDEGDFAEG--------ALQQLLEIYQ-------QEKDWQKAIDV---AERLEKLG-GDSLRVE-- 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 304 yylgLAHLaaeeyetaltvldtYCKISTdldddlslgrgyEAIAkvlqsQGEMTEAIKYLKKFVKIARNNfqsldlVRAS 383
Cdd:PRK11788 179 ----IAHF--------------YCELAQ------------QALA-----RGDLDAARALLKKALAADPQC------VRAS 217

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 578809447 384 TMLGDIYNEKGYYNKASECFQQAFDTTVELMSM---PLMD 420
Cdd:PRK11788 218 ILLGDLALAQGDYAAAIEALERVEEQDPEYLSEvlpKLME 257
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 304-409 2.70e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.88  E-value: 2.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 304 YYLGLAHLAAEEYETALTVLDTYCKISTDLDDdlslgrGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQsldlvrAS 383
Cdd:COG2956   12 YFKGLNYLLNGQPDKAIDLLEEALELDPETVE------AHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAE------AL 79

                         90       100
                 ....*....|....*....|....*.
gi 578809447 384 TMLGDIYNEKGYYNKASECFQQAFDT 409
Cdd:COG2956   80 LELAQDYLKAGLLDRAEELLEKLLEL 105
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 208-373 3.07e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.64  E-value: 3.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 208 AEAHMHMGLLYEEDGQLLEAAEHYEAFHQLTQGriwkdetgrslNLLACESLLRTYrllsdkmLENKEYKQAIKILIKAS 287
Cdd:COG4783    4 AEALYALAQALLLAGDYDEAEALLEKALELDPD-----------NPEAFALLGEIL-------LQLGDLDEAIVLLHEAL 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 288 EIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDdlslgrGYEAIAKVLQSQGEMTEAIKYLKKFV 367
Cdd:COG4783   66 ELDPD------EPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPE------AYLRLARAYRALGRPDEAIAALEKAL 133


                 ....*.
gi 578809447 368 KIARNN 373
Cdd:COG4783  134 ELDPDD 139
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 236-406 3.69e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.62  E-value: 3.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447  236 QLTQGRIWKDET--GRSLNLLACESLLRTyrLLSDKMLENKEYKQAIKILIKASEIAKEGSDKKMEaeasyyLGLAHLAA 313
Cdd:TIGR02917 339 QLRLGRVDEAIAtlSPALGLDPDDPAALS--LLGEAYLALGDFEKAAEYLAKATELDPENAAARTQ------LGISKLSQ 410

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447  314 EEYETALTVLDTyckiSTDLDDDlsLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSLDLvrastmLGDIYNEK 393
Cdd:TIGR02917 411 GDPSEAIADLET----AAQLDPE--LGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNL------LGAIYLGK 478

                         170
                  ....*....|...
gi 578809447  394 GYYNKASECFQQA 406
Cdd:TIGR02917 479 GDLAKAREAFEKA 491
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 271-406 4.09e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.64  E-value: 4.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 271 LENKEYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKIStdlDDDLSLgrgYEAIAKVL 350
Cdd:COG4783   15 LLAGDYDEAEALLEKALELDPD------NPEAFALLGEILLQLGDLDEAIVLLHEALELD---PDEPEA---RLNLGLAL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 578809447 351 QSQGEMTEAIKYLKKFVKIARNNFQSLDLvrastmLGDIYNEKGYYNKASECFQQA 406
Cdd:COG4783   83 LKAGDYDEALALLEKALKLDPEHPEAYLR------LARAYRALGRPDEAIAALEKA 132
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 110-339 2.02e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.83  E-value: 2.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 110 LFALMERWDALREAARVRSLFWLQKPLEEQPDKLDYLYHYLTRAEDAERKESFEDVHNNLYALACYFNNSEDKWvrnHFY 189
Cdd:COG3914   25 ELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEAL---ALY 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 190 ERcfkiaqLIKIDcgKKEAEAHMHMGLLYEEDGQLLEAAEHYEAFHQLtqgriwKDETGRSLNLLAcESLLRTYRllsdk 269
Cdd:COG3914  102 RR------ALALN--PDNAEALFNLGNLLLALGRLEEALAALRRALAL------NPDFAEAYLNLG-EALRRLGR----- 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 270 mlenkeYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDDLSL 339
Cdd:COG3914  162 ------LEEAIAALRRALELDPD------NAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSN 219
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 300-409 3.63e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 40.37  E-value: 3.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 300 AEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDDLSlgrgyeAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSLDL 379
Cdd:COG4235   17 AEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALL------DLAEALLAAGDTEEAEELLERALALDPDNPEALYL 90

                         90       100       110
                 ....*....|....*....|....*....|
gi 578809447 380 vrastmLGDIYNEKGYYNKASECFQQAFDT 409
Cdd:COG4235   91 ------LGLAAFQQGDYAEAIAAWQKLLAL 114
TPR_12 pfam13424
Tetratricopeptide repeat;
343-408 9.41e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.14  E-value: 9.41e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578809447  343 YEAIAKVLQSQGEMTEAIKYLKKFVKIARNNF--QSLDLVRASTMLGDIYNEKGYYNKASECFQQAFD 408
Cdd:pfam13424   6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLgpDHPLTATTLLNLGRLYLELGRYEEALELLERALA 73
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
333-406 1.49e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.38  E-value: 1.49e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578809447 333 LDDDLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSLdlvrasTMLGDIYNEKGYYNKASECFQQA 406
Cdd:COG0457    1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEAL------YNLGLAYLRLGRYEEALADYEQA 68
TPR_12 pfam13424
Tetratricopeptide repeat;
258-323 1.51e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 37.37  E-value: 1.51e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578809447  258 SLLRTYRLLSDKMLENKEYKQAIKILIKASEIAKE--GSDKKMEAEASYYLGLAHLAAEEYETALTVL 323
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRllGPDHPLTATTLLNLGRLYLELGRYEEALELL 68
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
208-401 4.23e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.83  E-value: 4.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 208 AEAHMHMGLLYEEDGQLLEAAEHYEAFHQLtqgriwkdetgRSLNLLACESLLRTYRLLsdkmlenKEYKQAIKILIKAS 287
Cdd:COG0457   76 AEALNNLGLALQALGRYEEALEDYDKALEL-----------DPDDAEALYNLGLALLEL-------GRYDEAIEAYERAL 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 288 EIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDDLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFV 367
Cdd:COG0457  138 ELDPD------DADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKL 211

                        170       180       190
                 ....*....|....*....|....*....|....
gi 578809447 368 KIARNNFQSLDLVRASTMLGDIYNEKGYYNKASE 401
Cdd:COG0457  212 AILTLAALAELLLLALALLLALRLAALALYQYRA 245
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 260-382 6.21e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.91  E-value: 6.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 260 LRTYRLLSDKMLENKEYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTyckiSTDLDDDLSL 339
Cdd:COG4235   17 AEGWLLLGRAYLRLGRYDEALAAYEKALRLDPD------NADALLDLAEALLAAGDTEEAEELLER----ALALDPDNPE 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 578809447 340 GRGYEAIAkvLQSQGEMTEAIKYLKKFVKIARNNFQSLDLVRA 382
Cdd:COG4235   87 ALYLLGLA--AFQQGDYAEAIAAWQKLLALLPADAPARLLEAS 127
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 271-406 6.59e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.30  E-value: 6.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447  271 LENKEYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDDLSLgrgyeaIAKVL 350
Cdd:TIGR02917 272 FQKKNYEDARETLQDALKSAPE------YLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRL------LASIQ 339

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 578809447  351 QSQGEMTEAIKYLKKFVKIARNNFQSLdlvrasTMLGDIYNEKGYYNKASECFQQA 406
Cdd:TIGR02917 340 LRLGRVDEAIATLSPALGLDPDDPAAL------SLLGEAYLALGDFEKAAEYLAKA 389
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 308-405 6.75e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 36.51  E-value: 6.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 308 LAHLAAEEYETALTVLDtycKISTDLDDDLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSLDlvrASTMLG 387
Cdd:COG1729    1 KALLKAGDYDEAIAAFK---AFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPD---ALLKLG 74

                         90
                 ....*....|....*...
gi 578809447 388 DIYNEKGYYNKASECFQQ 405
Cdd:COG1729   75 LSYLELGDYDKARATLEE 92
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
271-375 8.41e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 35.92  E-value: 8.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 271 LENKEYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALtvldtycKISTDLDDDLSLGRGYEAIAKVL 350
Cdd:COG3063    3 LKLGDLEEAEEYYEKALELDPD------NADALNNLGLLLLEQGRYDEAI-------ALEKALKLDPNNAEALLNLAELL 69

                         90       100
                 ....*....|....*....|....*
gi 578809447 351 QSQGEMTEAIKYLKKFVKIARNNFQ 375
Cdd:COG3063   70 LELGDYDEALAYLERALELDPSALR 94
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 206-370 9.87e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 36.86  E-value: 9.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 206 KEAEAHMHMGLLYEEDGQLLEAAEHYEAFHQLTQGRIWKDETGRSLNLLACESLLRTYRLLsdkmLENKEYKQAIKILIK 285
Cdd:COG5010    4 LEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLY----NKLGDFEESLALLEQ 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809447 286 ASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDddlslgRGYEAIAKVLQSQGEMTEAIKYLKK 365
Cdd:COG5010   80 ALQLDPN------NPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNP------NAYSNLAALLLSLGQDDEAKAALQR 147


                 ....*
gi 578809447 366 FVKIA 370
Cdd:COG5010  148 ALGTS 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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