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Conserved domains on  [gi|578803957|ref|XP_006712445|]
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CLIP-associating protein 1 isoform X18 [Homo sapiens]

Protein Classification

HEAT and CLASP_N domain-containing protein( domain architecture ID 10382707)

HEAT and CLASP_N domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CLASP_N super family cl20455
CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). ...
 324-537 6.73e-29

CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present. In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1.


The actual alignment was detected with superfamily member pfam12348:

Pssm-ID: 432496  Cd Length: 227  Bit Score: 116.15  E-value: 6.73e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578803957   324 INKIREILS--DDK---HDWEQRVNALKKIRSLLLAGAAE--YDNFFQHLR-LLDGAFKlSAKDLRSQVVREACITLGHL 395
Cdd:pfam12348    2 DDKFRELLPafEGKeteLNWDAREKNITKLRSLIKGNAPEdfPPEFFEGLKsLLDGILK-AVLSLRTTLSSTGCHLLKEL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578803957   396 SSVLGNKFDHGAEAIMPTIFNLIPNSAKIMATSGVVAVRLIIRH-THIPRLIPVITSNCTSKSVAVRRRCFEFLDLLLQE 474
Cdd:pfam12348   81 AIQLGHHIDPMAEILLPTLLKLCGDTKKITSQNANQAVAAILSNaSYTPRILQHISAASQDKNVQPREYSAIWLKILLRR 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578803957   475 WQTH--SLERH--ISVLAETIKKGIHDADSEARIEARKCYWGFHSHFSREAEHLYHTLESSYQKALQ 537
Cdd:pfam12348  161 HGHHksHIEHSggLRLIEKSLKKGLEDANPGVRETARSTFWEFFKVWPSRAKSLLSTLDPNVRKALE 227
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 168-198 2.53e-05

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


:

Pssm-ID: 460773  Cd Length: 31  Bit Score: 42.52  E-value: 2.53e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 578803957   168 IVPHICNLLGDPNSQVRDAAINSLVEIYRHV 198
Cdd:pfam02985    1 LLPLLLKLLNDPSPEVREAAAEALGELAEVL 31
CLASP_N super family cl20455
CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). ...
 77-208 5.17e-04

CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present. In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1.


The actual alignment was detected with superfamily member pfam12348:

Pssm-ID: 432496  Cd Length: 227  Bit Score: 43.35  E-value: 5.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578803957    77 LVTRLQDRFKAQIGTVLPSLIDRLGDAKDSVREQDQTLLLKIMDQAANPQYVWDRMLGGFKHKNFRTRE------GICLC 150
Cdd:pfam12348   80 LAIQLGHHIDPMAEILLPTLLKLCGDTKKITSQNANQAVAAILSNASYTPRILQHISAASQDKNVQPREysaiwlKILLR 159

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 578803957   151 LIATLNASGAQTLTLSKIVPHICNLLGDPNSQVRDAAINSLVEIYRHVGERVRADLSK 208
Cdd:pfam12348  160 RHGHHKSHIEHSGGLRLIEKSLKKGLEDANPGVRETARSTFWEFFKVWPSRAKSLLST 217
 
Name Accession Description Interval E-value
CLASP_N pfam12348
CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). ...
 324-537 6.73e-29

CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present. In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1.


Pssm-ID: 432496  Cd Length: 227  Bit Score: 116.15  E-value: 6.73e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578803957   324 INKIREILS--DDK---HDWEQRVNALKKIRSLLLAGAAE--YDNFFQHLR-LLDGAFKlSAKDLRSQVVREACITLGHL 395
Cdd:pfam12348    2 DDKFRELLPafEGKeteLNWDAREKNITKLRSLIKGNAPEdfPPEFFEGLKsLLDGILK-AVLSLRTTLSSTGCHLLKEL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578803957   396 SSVLGNKFDHGAEAIMPTIFNLIPNSAKIMATSGVVAVRLIIRH-THIPRLIPVITSNCTSKSVAVRRRCFEFLDLLLQE 474
Cdd:pfam12348   81 AIQLGHHIDPMAEILLPTLLKLCGDTKKITSQNANQAVAAILSNaSYTPRILQHISAASQDKNVQPREYSAIWLKILLRR 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578803957   475 WQTH--SLERH--ISVLAETIKKGIHDADSEARIEARKCYWGFHSHFSREAEHLYHTLESSYQKALQ 537
Cdd:pfam12348  161 HGHHksHIEHSggLRLIEKSLKKGLEDANPGVRETARSTFWEFFKVWPSRAKSLLSTLDPNVRKALE 227
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 168-198 2.53e-05

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 42.52  E-value: 2.53e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 578803957   168 IVPHICNLLGDPNSQVRDAAINSLVEIYRHV 198
Cdd:pfam02985    1 LLPLLLKLLNDPSPEVREAAAEALGELAEVL 31
CLASP_N pfam12348
CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). ...
 77-208 5.17e-04

CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present. In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1.


Pssm-ID: 432496  Cd Length: 227  Bit Score: 43.35  E-value: 5.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578803957    77 LVTRLQDRFKAQIGTVLPSLIDRLGDAKDSVREQDQTLLLKIMDQAANPQYVWDRMLGGFKHKNFRTRE------GICLC 150
Cdd:pfam12348   80 LAIQLGHHIDPMAEILLPTLLKLCGDTKKITSQNANQAVAAILSNASYTPRILQHISAASQDKNVQPREysaiwlKILLR 159

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 578803957   151 LIATLNASGAQTLTLSKIVPHICNLLGDPNSQVRDAAINSLVEIYRHVGERVRADLSK 208
Cdd:pfam12348  160 RHGHHKSHIEHSGGLRLIEKSLKKGLEDANPGVRETARSTFWEFFKVWPSRAKSLLST 217
 
Name Accession Description Interval E-value
CLASP_N pfam12348
CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). ...
 324-537 6.73e-29

CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present. In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1.


Pssm-ID: 432496  Cd Length: 227  Bit Score: 116.15  E-value: 6.73e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578803957   324 INKIREILS--DDK---HDWEQRVNALKKIRSLLLAGAAE--YDNFFQHLR-LLDGAFKlSAKDLRSQVVREACITLGHL 395
Cdd:pfam12348    2 DDKFRELLPafEGKeteLNWDAREKNITKLRSLIKGNAPEdfPPEFFEGLKsLLDGILK-AVLSLRTTLSSTGCHLLKEL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578803957   396 SSVLGNKFDHGAEAIMPTIFNLIPNSAKIMATSGVVAVRLIIRH-THIPRLIPVITSNCTSKSVAVRRRCFEFLDLLLQE 474
Cdd:pfam12348   81 AIQLGHHIDPMAEILLPTLLKLCGDTKKITSQNANQAVAAILSNaSYTPRILQHISAASQDKNVQPREYSAIWLKILLRR 160

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578803957   475 WQTH--SLERH--ISVLAETIKKGIHDADSEARIEARKCYWGFHSHFSREAEHLYHTLESSYQKALQ 537
Cdd:pfam12348  161 HGHHksHIEHSggLRLIEKSLKKGLEDANPGVRETARSTFWEFFKVWPSRAKSLLSTLDPNVRKALE 227
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 168-198 2.53e-05

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 42.52  E-value: 2.53e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 578803957   168 IVPHICNLLGDPNSQVRDAAINSLVEIYRHV 198
Cdd:pfam02985    1 LLPLLLKLLNDPSPEVREAAAEALGELAEVL 31
CLASP_N pfam12348
CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). ...
 77-208 5.17e-04

CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present. In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1.


Pssm-ID: 432496  Cd Length: 227  Bit Score: 43.35  E-value: 5.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578803957    77 LVTRLQDRFKAQIGTVLPSLIDRLGDAKDSVREQDQTLLLKIMDQAANPQYVWDRMLGGFKHKNFRTRE------GICLC 150
Cdd:pfam12348   80 LAIQLGHHIDPMAEILLPTLLKLCGDTKKITSQNANQAVAAILSNASYTPRILQHISAASQDKNVQPREysaiwlKILLR 159

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 578803957   151 LIATLNASGAQTLTLSKIVPHICNLLGDPNSQVRDAAINSLVEIYRHVGERVRADLSK 208
Cdd:pfam12348  160 RHGHHKSHIEHSGGLRLIEKSLKKGLEDANPGVRETARSTFWEFFKVWPSRAKSLLST 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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