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Conserved domains on  [gi|578801419|ref|XP_006711569|]
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toll-like receptor 5 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 693-837 4.58e-37

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


:

Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 136.73  E-value: 4.58e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419  693 YDAYLCFS-SKDFTWVQNALLKHLDtqysdQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEA 771
Cdd:pfam01582   1 YDVFLSFRgSDTREWFVSHLLKELK-----QKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419  772 FSYAQGRCLsDLNSALIMVVVGSLSQYQL-------MKHQSIRGFVQKQQYLRWPEDL------------QDVGWFLHKL 832
Cdd:pfam01582  76 LVKILECAL-DLGQKVIPIFYEVDPSDVRkqtgsfgKAFKKHKKVLTEEKVLKWRGALnevaniwhsksvSDESKFWKKI 154


                  ....*
gi 578801419  833 SQQIL 837
Cdd:pfam01582 155 AYDIS 159
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
288-577 4.54e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 4.54e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 288 SSVRHLDLShgfvfslNSRVFETLKDLKVLNLAYNKINKIADEaFYGLDNLQVLNLSYNLLGELySSNFYGLPKVAYIDL 367
Cdd:COG4886   96 TNLTELDLS-------GNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDL 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 368 QKNHIAIIqDQTFKFLEKLQTLDLRDNALTtihfipSIPDIFLSGNKLVTLpkinltanliHLSENRLENLDIlyFLLRV 447
Cdd:COG4886  167 SNNQLTDL-PEELGNLTNLKELDLSNNQIT------DLPEPLGNLTNLEEL----------DLSGNQLTDLPE--PLANL 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 448 PHLQILILNQNRFSSCsgdqtpsenPSLEQLflgenmlqlawetelcwdvfeglSHLQVLYLNHNYLNSLPPgvFSHLTA 527
Cdd:COG4886  228 TNLETLDLSNNQLTDL---------PELGNL-----------------------TNLEELDLSNNQLTDLPP--LANLTN 273

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 578801419 528 LRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDIT 577
Cdd:COG4886  274 LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323
LRR_8 pfam13855
Leucine rich repeat;
95-182 5.58e-06

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 5.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419   95 PNLRILDLGSSKIYFLHPDAFQGlfhlfelrlyfcglsdavlkdgyfrnLKALTRLDLSKNQIRSLYLHpSFGKLNSLKS 174
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKG--------------------------LSNLKVLDLSNNLLTTLSPG-AFSGLPSLRY 53


                  ....*...
gi 578801419  175 IDFSSNQI 182
Cdd:pfam13855  54 LDLSGNRL 61
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 554-634 2.43e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.54  E-value: 2.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419   554 DISRNQLLAPNPDVF---VSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIyCVYPDSFSGVSLF--SLSTEG 628
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAAL-CAGPGALAGQPLLgiPLLDSG 79


                   ....*.
gi 578801419   629 CDEEEV 634
Cdd:TIGR00864   80 CDEEYV 85
 
Name Accession Description Interval E-value
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 693-837 4.58e-37

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 136.73  E-value: 4.58e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419  693 YDAYLCFS-SKDFTWVQNALLKHLDtqysdQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEA 771
Cdd:pfam01582   1 YDVFLSFRgSDTREWFVSHLLKELK-----QKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419  772 FSYAQGRCLsDLNSALIMVVVGSLSQYQL-------MKHQSIRGFVQKQQYLRWPEDL------------QDVGWFLHKL 832
Cdd:pfam01582  76 LVKILECAL-DLGQKVIPIFYEVDPSDVRkqtgsfgKAFKKHKKVLTEEKVLKWRGALnevaniwhsksvSDESKFWKKI 154


                  ....*
gi 578801419  833 SQQIL 837
Cdd:pfam01582 155 AYDIS 159
TIR smart00255
Toll - interleukin 1 - resistance;
692-827 4.81e-27

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 107.02  E-value: 4.81e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419   692 KYDAYLCFSSKDftWVQNALLKHLDTQYSdqnRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEA 771
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLR---GYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 578801419   772 FSYAQGRCLSDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKqQYLRWPEDLQDVGW 827
Cdd:smart00255  76 LVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQFW 130
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
288-577 4.54e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 4.54e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 288 SSVRHLDLShgfvfslNSRVFETLKDLKVLNLAYNKINKIADEaFYGLDNLQVLNLSYNLLGELySSNFYGLPKVAYIDL 367
Cdd:COG4886   96 TNLTELDLS-------GNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDL 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 368 QKNHIAIIqDQTFKFLEKLQTLDLRDNALTtihfipSIPDIFLSGNKLVTLpkinltanliHLSENRLENLDIlyFLLRV 447
Cdd:COG4886  167 SNNQLTDL-PEELGNLTNLKELDLSNNQIT------DLPEPLGNLTNLEEL----------DLSGNQLTDLPE--PLANL 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 448 PHLQILILNQNRFSSCsgdqtpsenPSLEQLflgenmlqlawetelcwdvfeglSHLQVLYLNHNYLNSLPPgvFSHLTA 527
Cdd:COG4886  228 TNLETLDLSNNQLTDL---------PELGNL-----------------------TNLEELDLSNNQLTDLPP--LANLTN 273

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 578801419 528 LRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDIT 577
Cdd:COG4886  274 LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323
LRR_8 pfam13855
Leucine rich repeat;
288-348 5.67e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 5.67e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578801419  288 SSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL 348
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 90-581 3.25e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.63  E-value: 3.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419  90 AFRNLPNLRILDLGSSKIYFLHPDA-----------------FQG------LFHLFELRLYFCGLSDAVLKD-GYFRNLK 145
Cdd:PLN00113  88 AIFRLPYIQTINLSNNQLSGPIPDDifttssslrylnlsnnnFTGsiprgsIPNLETLDLSNNMLSGEIPNDiGSFSSLK 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 146 ALtrlDLSKNQIRSlYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEplQGKTLSFFSLAANSLYSRVSVDWGKCMNpfrn 225
Cdd:PLN00113 168 VL---DLGGNVLVG-KIPNSLTNLTSLEFLTLASNQLVGQIPRELG--QMKSLKWIYLGYNNLSGEIPYEIGGLTS---- 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 226 mvLEILDVSGNGWTVDITGNFSNaISKSQAFSLIlahhimgagfgfhnikdpdQNTFAGLARSSVR------HLDLSHGF 299
Cdd:PLN00113 238 --LNHLDLVYNNLTGPIPSSLGN-LKNLQYLFLY-------------------QNKLSGPIPPSIFslqkliSLDLSDNS 295

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 300 VFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLnlsynllgELYSSNFYG-LPKvayiDLQKNHiaiiqdq 378
Cdd:PLN00113 296 LSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVL--------QLWSNKFSGeIPK----NLGKHN------- 356

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 379 tfkfleKLQTLDLRDNALTTihfipSIPDIFLSGNKLVTL------------PKINLTANL--IHLSENRLE-------- 436
Cdd:PLN00113 357 ------NLTVLDLSTNNLTG-----EIPEGLCSSGNLFKLilfsnslegeipKSLGACRSLrrVRLQDNSFSgelpseft 425

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 437 NLDILYFL---------------LRVPHLQILILNQNRFSSCSGDQTPSENpsLEQLFLGENMLqlaweTELCWDVFEGL 501
Cdd:PLN00113 426 KLPLVYFLdisnnnlqgrinsrkWDMPSLQMLSLARNKFFGGLPDSFGSKR--LENLDLSRNQF-----SGAVPRKLGSL 498

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 502 SHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLT---VLSHNDLPAnLEILDISRNQL---LAPNPDVFVSLSVLD 575
Cdd:PLN00113 499 SELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgqiPASFSEMPV-LSQLDLSQNQLsgeIPKNLGNVESLVQVN 577


                 ....*.
gi 578801419 576 ITHNKF 581
Cdd:PLN00113 578 ISHNHL 583
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 328-581 7.54e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 58.14  E-value: 7.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 328 ADEAFYGLDNLQVLNLSYNLLGELY----SSNFYGLPKVAYIDLQKNHIAIIQDQT------FKFLEKLQTLDLRDNALT 397
Cdd:cd00116   15 ATELLPKLLCLQVLRLEGNTLGEEAakalASALRPQPSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDNALG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 398 --TIHFIPSipdiFLSGNKLVTLpkinltanliHLSENRLENlDILYFLLRV-----PHLQILILNQNRFSSCSGDQTPS 470
Cdd:cd00116   95 pdGCGVLES----LLRSSSLQEL----------KLNNNGLGD-RGLRLLAKGlkdlpPALEKLVLGRNRLEGASCEALAK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 471 E---NPSLEQLFLGENMLQLAWETELCWDvFEGLSHLQVLYLNHNYLN----SLPPGVFSHLTALRGLSLNSNRLT---- 539
Cdd:cd00116  160 AlraNRDLKELNLANNGIGDAGIRALAEG-LKANCNLEVLDLNNNGLTdegaSALAETLASLKSLEVLNLGDNNLTdaga 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578801419 540 --VLSHNDLPA-NLEILDISRNQL-------LAPNPDVFVSLSVLDITHNKF 581
Cdd:cd00116  239 aaLASALLSPNiSLLTLSLSCNDItddgakdLAEVLAEKESLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
95-182 5.58e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 5.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419   95 PNLRILDLGSSKIYFLHPDAFQGlfhlfelrlyfcglsdavlkdgyfrnLKALTRLDLSKNQIRSLYLHpSFGKLNSLKS 174
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKG--------------------------LSNLKVLDLSNNLLTTLSPG-AFSGLPSLRY 53


                  ....*...
gi 578801419  175 IDFSSNQI 182
Cdd:pfam13855  54 LDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 554-634 2.43e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.54  E-value: 2.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419   554 DISRNQLLAPNPDVF---VSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIyCVYPDSFSGVSLF--SLSTEG 628
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAAL-CAGPGALAGQPLLgiPLLDSG 79


                   ....*.
gi 578801419   629 CDEEEV 634
Cdd:TIGR00864   80 CDEEYV 85
LRRCT smart00082
Leucine rich repeat C-terminal domain;
579-630 4.73e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.57  E-value: 4.73e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 578801419   579 NKFICECELSTFINWLNHTNVTiaGPPADIYCVYPDSFSG-VSLFSLSTEGCD 630
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHL--QDPVDLRCASPSSLRGpLLELLHSEFKCP 51
LRR smart00370
Leucine-rich repeats, outliers;
501-524 2.97e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 2.97e-03
                           10        20
                   ....*....|....*....|....
gi 578801419   501 LSHLQVLYLNHNYLNSLPPGVFSH 524
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 89-208 8.27e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 8.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419  89 EAFRNLPNLRILDLGSSKIyflHPDAFQGLF-------HLFELRLYFCGLSDAVLKD--GYFRNLKALTRLDLSKNQIRS 159
Cdd:cd00116  159 KALRANRDLKELNLANNGI---GDAGIRALAeglkancNLEVLDLNNNGLTDEGASAlaETLASLKSLEVLNLGDNNLTD 235

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 578801419 160 ---LYLHPSFGKLN-SLKSIDFSSNQIFLV-CEHELEPLQGK-TLSFFSLAANSL 208
Cdd:cd00116  236 agaAALASALLSPNiSLLTLSLSCNDITDDgAKDLAEVLAEKeSLLELDLRGNKF 290
 
Name Accession Description Interval E-value
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 693-837 4.58e-37

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 136.73  E-value: 4.58e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419  693 YDAYLCFS-SKDFTWVQNALLKHLDtqysdQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEA 771
Cdd:pfam01582   1 YDVFLSFRgSDTREWFVSHLLKELK-----QKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDE 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419  772 FSYAQGRCLsDLNSALIMVVVGSLSQYQL-------MKHQSIRGFVQKQQYLRWPEDL------------QDVGWFLHKL 832
Cdd:pfam01582  76 LVKILECAL-DLGQKVIPIFYEVDPSDVRkqtgsfgKAFKKHKKVLTEEKVLKWRGALnevaniwhsksvSDESKFWKKI 154


                  ....*
gi 578801419  833 SQQIL 837
Cdd:pfam01582 155 AYDIS 159
TIR smart00255
Toll - interleukin 1 - resistance;
692-827 4.81e-27

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 107.02  E-value: 4.81e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419   692 KYDAYLCFSSKDftWVQNALLKHLDTQYSdqnRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEA 771
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLR---GYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 578801419   772 FSYAQGRCLSDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKqQYLRWPEDLQDVGW 827
Cdd:smart00255  76 LVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQFW 130
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
288-577 4.54e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 4.54e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 288 SSVRHLDLShgfvfslNSRVFETLKDLKVLNLAYNKINKIADEaFYGLDNLQVLNLSYNLLGELySSNFYGLPKVAYIDL 367
Cdd:COG4886   96 TNLTELDLS-------GNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDL 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 368 QKNHIAIIqDQTFKFLEKLQTLDLRDNALTtihfipSIPDIFLSGNKLVTLpkinltanliHLSENRLENLDIlyFLLRV 447
Cdd:COG4886  167 SNNQLTDL-PEELGNLTNLKELDLSNNQIT------DLPEPLGNLTNLEEL----------DLSGNQLTDLPE--PLANL 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 448 PHLQILILNQNRFSSCsgdqtpsenPSLEQLflgenmlqlawetelcwdvfeglSHLQVLYLNHNYLNSLPPgvFSHLTA 527
Cdd:COG4886  228 TNLETLDLSNNQLTDL---------PELGNL-----------------------TNLEELDLSNNQLTDLPP--LANLTN 273

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 578801419 528 LRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDIT 577
Cdd:COG4886  274 LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
288-553 1.63e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 1.63e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 288 SSVRHLDLSHGFVFSLNSrVFETLKDLKVLNLAYNKINKIaDEAFYGLDNLQVLNLSYNLLGELySSNFYGLPKVAYIDL 367
Cdd:COG4886  136 TNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDL 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 368 QKNHIAIIqDQTFKFLEKLQTLDLRDNALTTIHFIPSIPD---IFLSGNKLVTLPKINLTANL--IHLSENRLENLDILY 442
Cdd:COG4886  213 SGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPELGNLTNleeLDLSNNQLTDLPPLANLTNLktLDLSNNQLTDLKLKE 291

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 443 FLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVF 522
Cdd:COG4886  292 LELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGL 371

                        250       260       270
                 ....*....|....*....|....*....|.
gi 578801419 523 SHLTALRGLSLNSNRLTVLSHNDLPANLEIL 553
Cdd:COG4886  372 LGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
309-560 3.31e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 3.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 309 ETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNllgelysSNFYGLPKVAYIDLQKNHIAIIqDQTFKFLEKLQT 388
Cdd:COG4886   69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKE 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 389 LDLRDNALTtihfipSIPDIFLSGNKLVTLpkinltanliHLSENRLENLDIlyFLLRVPHLQILILNQNRFSScsGDQT 468
Cdd:COG4886  141 LDLSNNQLT------DLPEPLGNLTNLKSL----------DLSNNQLTDLPE--ELGNLTNLKELDLSNNQITD--LPEP 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 469 PSENPSLEQLFLGENMLqlaweTELCwDVFEGLSHLQVLYLNHNYLNSLPpgVFSHLTALRGLSLNSNRLTVLSHNDLPA 548
Cdd:COG4886  201 LGNLTNLEELDLSGNQL-----TDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLANLT 272

                        250
                 ....*....|..
gi 578801419 549 NLEILDISRNQL 560
Cdd:COG4886  273 NLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
291-552 6.52e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 6.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 291 RHLDLSHGFVFSLnSRVFETLKDLKVLNLAYNKINKIADEaFYGLDNLQVLNLSYNLLGELySSNFYGLPKVAYIDLQKN 370
Cdd:COG4886  162 KSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNN 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 371 HIAIIQDqtFKFLEKLQTLDLRDNALTTIHF---IPSIPDIFLSGNKLVTLpkinltaNLIHLSENRLENLDILYFLLRV 447
Cdd:COG4886  239 QLTDLPE--LGNLTNLEELDLSNNQLTDLPPlanLTNLKTLDLSNNQLTDL-------KLKELELLLGLNSLLLLLLLLN 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 448 PHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTA 527
Cdd:COG4886  310 LLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTL 389

                        250       260
                 ....*....|....*....|....*
gi 578801419 528 LRGLSLNSNRLTVLSHNDLPANLEI 552
Cdd:COG4886  390 LLLLLTTTAGVLLLTLALLDAVNTE 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-507 1.23e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.73  E-value: 1.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419  51 LLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCG 130
Cdd:COG4886   28 LLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 131 LsdavlkdgyFRNLKALTRLDLSKNQIRSLYlhPSFGKLNSLKSIDFSSNQIflvcEHELEPLQG-KTLSFFSLAANSLy 209
Cdd:COG4886  108 E---------LSNLTNLESLDLSGNQLTDLP--EELANLTNLKELDLSNNQL----TDLPEPLGNlTNLKSLDLSNNQL- 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 210 SRVSVDWGKCMNpfrnmvLEILDVSGNGWTvditgNFSNAISKsqafslilahhimgagfgfhnikdpdqntfaglaRSS 289
Cdd:COG4886  172 TDLPEELGNLTN------LKELDLSNNQIT-----DLPEPLGN----------------------------------LTN 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 290 VRHLDLSHGFVFSLnSRVFETLKDLKVLNLAYNKINKIADeaFYGLDNLQVLNLSYNLLGELysSNFYGLPKVAYIDLQK 369
Cdd:COG4886  207 LEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSN 281

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 370 NHIAIIQdqtfkfLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPH 449
Cdd:COG4886  282 NQLTDLK------LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLL 355

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 578801419 450 LQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVL 507
Cdd:COG4886  356 LNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-462 2.94e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.58  E-value: 2.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419  37 NLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGsskiyflHPDAFQ 116
Cdd:COG4886   38 LLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLS-------GNEELS 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 117 GLFHLFELRLYFCGLSDAvlkDGYFRNLKALTRLDLSKNQIRSLylHPSFGKLNSLKSIDFSSNQIFLVCEhELEPLqgK 196
Cdd:COG4886  111 NLTNLESLDLSGNQLTDL---PEELANLTNLKELDLSNNQLTDL--PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNL--T 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 197 TLSFFSLAANSLySRVSVDWGKCMNpfrnmvLEILDVSGNgwtvDITgNFSNAISKSqafslilahhimgagfgfhnikd 276
Cdd:COG4886  183 NLKELDLSNNQI-TDLPEPLGNLTN------LEELDLSGN----QLT-DLPEPLANL----------------------- 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 277 pdqntfaglarSSVRHLDLSHGFVFSLNSrvFETLKDLKVLNLAYNKINKIADEAfyGLDNLQVLNLSYNLLGELYSSNF 356
Cdd:COG4886  228 -----------TNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKEL 292

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 357 YGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLE 436
Cdd:COG4886  293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372

                        410       420
                 ....*....|....*....|....*.
gi 578801419 437 NLDILYFLLRVPHLQILILNQNRFSS 462
Cdd:COG4886  373 GLLEATLLTLALLLLTLLLLLLTTTA 398
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
337-581 5.50e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 5.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 337 NLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLV 416
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 417 TLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCsgDQTPSENPSLEQLFLGENMLqlaweTELcWD 496
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDL--PEELANLTNLKELDLSNNQL-----TDL-PE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 497 VFEGLSHLQVLYLNHNYLNSLPPgVFSHLTALRGLSLNSNRLTVLSH--NDLPaNLEILDISRNQLLAPNPDV--FVSLS 572
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEplGNLT-NLEELDLSGNQLTDLPEPLanLTNLE 231


                 ....*....
gi 578801419 573 VLDITHNKF 581
Cdd:COG4886  232 TLDLSNNQL 240
LRR_8 pfam13855
Leucine rich repeat;
288-348 5.67e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 5.67e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578801419  288 SSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLL 348
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
314-372 5.90e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 5.90e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578801419  314 LKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHI 372
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
473-538 3.78e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 3.78e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578801419  473 PSLEQLFLGENMLqlaweTELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRL 538
Cdd:pfam13855   1 PNLRSLDLSNNRL-----TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 696-782 6.78e-10

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 57.33  E-value: 6.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419  696 YLCFSSKDFTWVQnALLKHLDtqysdQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYA 775
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALE-----AAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAA 75


                  ....*..
gi 578801419  776 QGRCLSD 782
Cdd:pfam13676  76 LADPEGR 82
LRR_8 pfam13855
Leucine rich repeat;
502-560 1.79e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.79e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578801419  502 SHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDL--PANLEILDISRNQL 560
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 90-581 3.25e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.63  E-value: 3.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419  90 AFRNLPNLRILDLGSSKIYFLHPDA-----------------FQG------LFHLFELRLYFCGLSDAVLKD-GYFRNLK 145
Cdd:PLN00113  88 AIFRLPYIQTINLSNNQLSGPIPDDifttssslrylnlsnnnFTGsiprgsIPNLETLDLSNNMLSGEIPNDiGSFSSLK 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 146 ALtrlDLSKNQIRSlYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEplQGKTLSFFSLAANSLYSRVSVDWGKCMNpfrn 225
Cdd:PLN00113 168 VL---DLGGNVLVG-KIPNSLTNLTSLEFLTLASNQLVGQIPRELG--QMKSLKWIYLGYNNLSGEIPYEIGGLTS---- 237

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 226 mvLEILDVSGNGWTVDITGNFSNaISKSQAFSLIlahhimgagfgfhnikdpdQNTFAGLARSSVR------HLDLSHGF 299
Cdd:PLN00113 238 --LNHLDLVYNNLTGPIPSSLGN-LKNLQYLFLY-------------------QNKLSGPIPPSIFslqkliSLDLSDNS 295

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 300 VFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLnlsynllgELYSSNFYG-LPKvayiDLQKNHiaiiqdq 378
Cdd:PLN00113 296 LSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVL--------QLWSNKFSGeIPK----NLGKHN------- 356

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 379 tfkfleKLQTLDLRDNALTTihfipSIPDIFLSGNKLVTL------------PKINLTANL--IHLSENRLE-------- 436
Cdd:PLN00113 357 ------NLTVLDLSTNNLTG-----EIPEGLCSSGNLFKLilfsnslegeipKSLGACRSLrrVRLQDNSFSgelpseft 425

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 437 NLDILYFL---------------LRVPHLQILILNQNRFSSCSGDQTPSENpsLEQLFLGENMLqlaweTELCWDVFEGL 501
Cdd:PLN00113 426 KLPLVYFLdisnnnlqgrinsrkWDMPSLQMLSLARNKFFGGLPDSFGSKR--LENLDLSRNQF-----SGAVPRKLGSL 498

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 502 SHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLT---VLSHNDLPAnLEILDISRNQL---LAPNPDVFVSLSVLD 575
Cdd:PLN00113 499 SELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgqiPASFSEMPV-LSQLDLSQNQLsgeIPKNLGNVESLVQVN 577


                 ....*.
gi 578801419 576 ITHNKF 581
Cdd:PLN00113 578 ISHNHL 583
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
383-580 4.44e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.10  E-value: 4.44e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 383 LEKLQT-LDLRDNALTTI-HFIP-SIPDIFLSGNKLVTLPKiNLTANLIHLSENrlENLdilyfLLRVPH-----LQILI 454
Cdd:PRK15370 176 LKNNKTeLRLKILGLTTIpACIPeQITTLILDNNELKSLPE-NLQGNIKTLYAN--SNQ-----LTSIPAtlpdtIQEME 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 455 LNQNRFSscsgdQTPSENPS-LEQLFLGENMLQLAWETelcwdVFEGLSHLQVLylnHNYLNSLPpgvfSHL-TALRGLS 532
Cdd:PRK15370 248 LSINRIT-----ELPERLPSaLQSLDLFHNKISCLPEN-----LPEELRYLSVY---DNSIRTLP----AHLpSGITHLN 310

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 578801419 533 LNSNRLTVLSHNdLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNK 580
Cdd:PRK15370 311 VQSNSLTALPET-LPPGLKTLEAGENALTSLPASLPPELQVLDVSKNQ 357
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 328-581 7.54e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 58.14  E-value: 7.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 328 ADEAFYGLDNLQVLNLSYNLLGELY----SSNFYGLPKVAYIDLQKNHIAIIQDQT------FKFLEKLQTLDLRDNALT 397
Cdd:cd00116   15 ATELLPKLLCLQVLRLEGNTLGEEAakalASALRPQPSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDNALG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 398 --TIHFIPSipdiFLSGNKLVTLpkinltanliHLSENRLENlDILYFLLRV-----PHLQILILNQNRFSSCSGDQTPS 470
Cdd:cd00116   95 pdGCGVLES----LLRSSSLQEL----------KLNNNGLGD-RGLRLLAKGlkdlpPALEKLVLGRNRLEGASCEALAK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 471 E---NPSLEQLFLGENMLQLAWETELCWDvFEGLSHLQVLYLNHNYLN----SLPPGVFSHLTALRGLSLNSNRLT---- 539
Cdd:cd00116  160 AlraNRDLKELNLANNGIGDAGIRALAEG-LKANCNLEVLDLNNNGLTdegaSALAETLASLKSLEVLNLGDNNLTdaga 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578801419 540 --VLSHNDLPA-NLEILDISRNQL-------LAPNPDVFVSLSVLDITHNKF 581
Cdd:cd00116  239 aaLASALLSPNiSLLTLSLSCNDItddgakdLAEVLAEKESLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
337-396 2.62e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 2.62e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419  337 NLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNAL 396
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
490-583 4.20e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.47  E-value: 4.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 490 ETELCWDVFeGLS--------HLQVLYLNHNYLNSLPPGVFSHLtalRGLSLNSNRLTVLSHNdLPANLEILDISRNQLL 561
Cdd:PRK15370 180 KTELRLKIL-GLTtipacipeQITTLILDNNELKSLPENLQGNI---KTLYANSNQLTSIPAT-LPDTIQEMELSINRIT 254

                         90       100
                 ....*....|....*....|..
gi 578801419 562 APNPDVFVSLSVLDITHNKFIC 583
Cdd:PRK15370 255 ELPERLPSALQSLDLFHNKISC 276
LRR_8 pfam13855
Leucine rich repeat;
95-182 5.58e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 5.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419   95 PNLRILDLGSSKIYFLHPDAFQGlfhlfelrlyfcglsdavlkdgyfrnLKALTRLDLSKNQIRSLYLHpSFGKLNSLKS 174
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKG--------------------------LSNLKVLDLSNNLLTTLSPG-AFSGLPSLRY 53


                  ....*...
gi 578801419  175 IDFSSNQI 182
Cdd:pfam13855  54 LDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 498-580 6.93e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 6.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 498 FEGLSHLQVLYLNHNYLNSLPPgvFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQL-----LAPNPDVFVSLS 572
Cdd:cd21340   42 LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLppgekLTFDPRSLAALS 119

                         90
                 ....*....|..
gi 578801419 573 ----VLDITHNK 580
Cdd:cd21340  120 nslrVLNISGNN 131
LRR_8 pfam13855
Leucine rich repeat;
84-126 7.13e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 7.13e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 578801419   84 LTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRL 126
Cdd:pfam13855  14 TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL 56
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 292-439 1.12e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 292 HLDLSHGFVFSLNSrvFETLKDLKVLNLAYNKINKIadEAFYGLDNLQVLNLSYNLLGE------LYSSNFYGLPKVAYI 365
Cdd:cd21340   50 HLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVV--EGLENLTNLEELHIENQRLPPgekltfDPRSLAALSNSLRVL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 366 DLQKNHIAIIQDqtFKFLEKLQTLDLRDNALTTIHFI-------PSIPDIFLSGNKLVTLPKINltANLIhLSENRLENL 438
Cdd:cd21340  126 NISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEELldllsswPSLRELDLTGNPVCKKPKYR--DKII-LASKSLEVL 200


                 .
gi 578801419 439 D 439
Cdd:cd21340  201 D 201
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 408-581 1.48e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 1.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 408 IFLSGNKLVTLPKINLTANL--IHLSENRLENLDILYFLlrvPHLQILILNQNR------FSSCsgdqtpsenPSLEQLF 479
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLkvLYLYDNKITKIENLEFL---TNLTHLYLQNNQiekienLENL---------VNLKKLY 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 480 LGENMLQlawetelcwdVFEGL---SHLQVLYLNHNylnSLPPGVfshltalrGLSLNSNRLTVLSHNdlpanLEILDIS 556
Cdd:cd21340   75 LGGNRIS----------VVEGLenlTNLEELHIENQ---RLPPGE--------KLTFDPRSLAALSNS-----LRVLNIS 128

                        170       180
                 ....*....|....*....|....*.
gi 578801419 557 RNQLLAPNP-DVFVSLSVLDITHNKF 581
Cdd:cd21340  129 GNNIDSLEPlAPLRNLEQLDASNNQI 154
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 367-579 2.00e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.70  E-value: 2.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 367 LQKNHIAIIQDqtFKFLEKLQTLDLRDNALTTIhfipsipdiflsgNKLVTLPkiNLTAnlIHLSEN---RLENLDILyf 443
Cdd:cd21340    9 LNDKNITKIDN--LSLCKNLKVLYLYDNKITKI-------------ENLEFLT--NLTH--LYLQNNqieKIENLENL-- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 444 llrvPHLQILILNQNRFSSCSGDQTPsenPSLEQLFLGENmlQLAWETELCWDVF--EGLSH-LQVLYLNHNYLNSLPPg 520
Cdd:cd21340   68 ----VNLKKLYLGGNRISVVEGLENL---TNLEELHIENQ--RLPPGEKLTFDPRslAALSNsLRVLNISGNNIDSLEP- 137

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578801419 521 vFSHLTalrglslnsnrltvlshndlpaNLEILDISRNQLLAPNPDVFV-----SLSVLDITHN 579
Cdd:cd21340  138 -LAPLR----------------------NLEQLDASNNQISDLEELLDLlsswpSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
360-415 2.23e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 2.23e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578801419  360 PKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIH-----FIPSIPDIFLSGNKL 415
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgafsGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 554-634 2.43e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 48.54  E-value: 2.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419   554 DISRNQLLAPNPDVF---VSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIyCVYPDSFSGVSLF--SLSTEG 628
Cdd:TIGR00864    1 DISNNKISTIEEGICanlCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAAL-CAGPGALAGQPLLgiPLLDSG 79


                   ....*.
gi 578801419   629 CDEEEV 634
Cdd:TIGR00864   80 CDEEYV 85
LRRCT smart00082
Leucine rich repeat C-terminal domain;
579-630 4.73e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 38.57  E-value: 4.73e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 578801419   579 NKFICECELSTFINWLNHTNVTiaGPPADIYCVYPDSFSG-VSLFSLSTEGCD 630
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHL--QDPVDLRCASPSSLRGpLLELLHSEFKCP 51
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 308-462 1.28e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 308 FETLKDLKVLNLAYNKINKIadEAFYGLDNLQVLNLSYNLLGELysSNFYGLPKVAYIDLQKNHIAIIQDqtFKFLEKLQ 387
Cdd:cd21340   20 LSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVEG--LENLTNLE 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 388 TLDLRDNAL---TTIHFIP-SIPDIF-------LSGNKLVTLPKINLTANLIHL--SENRLENL-DILYFLLRVPHLQIL 453
Cdd:cd21340   94 ELHIENQRLppgEKLTFDPrSLAALSnslrvlnISGNNIDSLEPLAPLRNLEQLdaSNNQISDLeELLDLLSSWPSLREL 173


                 ....*....
gi 578801419 454 ILNQNRFSS 462
Cdd:cd21340  174 DLTGNPVCK 182
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 324-534 2.14e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 41.78  E-value: 2.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419  324 INKIADEAFYGLDNLQVLNLSYNLlGELYSSNFYGLPKV-AYIDLQKNHIAIIQDQT----FKFLEKLQTLDL------- 391
Cdd:PLN03210  680 LNKLEDLDMSRCENLEILPTGINL-KSLYRLNLSGCSRLkSFPDISTNISWLDLDETaieeFPSNLRLENLDElilcemk 758

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419  392 ------RDNALTTIHFI--PSIPDIFLSGN-KLVTLPKI--NLTaNLIHLSENRLENLDILYFLLRVPHLQILilnqnRF 460
Cdd:PLN03210  759 seklweRVQPLTPLMTMlsPSLTRLFLSDIpSLVELPSSiqNLH-KLEHLEIENCINLETLPTGINLESLESL-----DL 832

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419  461 SSCSGDQT-PSENPSLEQLFLGENMLQ-LAWETE----LCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLN 534
Cdd:PLN03210  833 SGCSRLRTfPDISTNISDLNLSRTGIEeVPWWIEkfsnLSFLDMNGCNNLQRVSLNISKLKHLETVDFSDCGALTEASWN 912
LRR smart00370
Leucine-rich repeats, outliers;
501-524 2.97e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 2.97e-03
                           10        20
                   ....*....|....*....|....
gi 578801419   501 LSHLQVLYLNHNYLNSLPPGVFSH 524
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
501-524 2.97e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 2.97e-03
                           10        20
                   ....*....|....*....|....
gi 578801419   501 LSHLQVLYLNHNYLNSLPPGVFSH 524
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 89-208 8.27e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 8.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419  89 EAFRNLPNLRILDLGSSKIyflHPDAFQGLF-------HLFELRLYFCGLSDAVLKD--GYFRNLKALTRLDLSKNQIRS 159
Cdd:cd00116  159 KALRANRDLKELNLANNGI---GDAGIRALAeglkancNLEVLDLNNNGLTDEGASAlaETLASLKSLEVLNLGDNNLTD 235

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 578801419 160 ---LYLHPSFGKLN-SLKSIDFSSNQIFLV-CEHELEPLQGK-TLSFFSLAANSL 208
Cdd:cd00116  236 agaAALASALLSPNiSLLTLSLSCNDITDDgAKDLAEVLAEKeSLLELDLRGNKF 290
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 288-400 8.82e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 8.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801419 288 SSVRHLDLSH-----GFVFSLNSRVFETLKD-LKVLNLAYNKINKIADeaFYGLDNLQVLNLSYNLLGELyssnfyglpk 361
Cdd:cd21340   90 TNLEELHIENqrlppGEKLTFDPRSLAALSNsLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDL---------- 157

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 578801419 362 vayidlqkNHIAiiqdQTFKFLEKLQTLDLRDNALTTIH 400
Cdd:cd21340  158 --------EELL----DLLSSWPSLRELDLTGNPVCKKP 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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