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Conserved domains on  [gi|578800736|ref|XP_006711304|]
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flavin-containing monooxygenase 1 isoform X1 [Homo sapiens]

Protein Classification

flavin-binding monooxygenase-like family protein( domain architecture ID 1000557)

flavin-binding monooxygenase-like family protein; such as flavin-containing monooxygenases (FMOs) that catalyze the monooxygenation of a variety of substrates

EC:  1.14.13.-
Gene Ontology:  GO:0004497

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FMO-like super family cl30939
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 2-496 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


The actual alignment was detected with superfamily member pfam00743:

Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 941.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736    2 AKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEHVEEGRASLYKSVVSNSCKEMSCYSDFPFPEDYPNY 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736   82 VPNSQFLEYLKMYANHFDLLKHIQFKTKVCSVTKCSDSAVSGQWEVVTMHEEKQESAIFDAVMVCTGFLTNPYLPLDSFP 161
Cdd:pfam00743  81 MHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736  162 GINAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRIFDSGYPWDMVFMTRFQN 241
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736  242 MLRNSLPTPIVTWLMERKINNWLNHANYGLIPEDRTQLKEFVLNDELPGRIITGKVFIRPSIKE---------------- 305
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEftetsaifedgtveed 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736  306 -------------------SVVKVEDGQASLYKYIFPAHLQKPTLAIIGLIKPLGSMIPTGETQARWAVRVLKGVNKLPP 366
Cdd:pfam00743 321 idvvifatgytfafpfleeSLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPS 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736  367 PSVMIEEINARKENKPSWFGLCYCKALQSDYITYIDELLTYINAKPNLFSMLLTDPHLALTVFFGPCSPYQFRLTGPGKW 446
Cdd:pfam00743 401 QSEMMAEINKRQEKKIKRFGDSQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKW 480

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 578800736  447 EGARNAIMTQWDRTFKVIKARVVQESPSPFESF-LKVFSFLALLVAIFLIF 496
Cdd:pfam00743 481 EGARNAILTQWDRILKPLKTRVVEKSSSPASSFtLKIFGLPVVLVAIFLIL 531
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 2-496 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 941.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736    2 AKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEHVEEGRASLYKSVVSNSCKEMSCYSDFPFPEDYPNY 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736   82 VPNSQFLEYLKMYANHFDLLKHIQFKTKVCSVTKCSDSAVSGQWEVVTMHEEKQESAIFDAVMVCTGFLTNPYLPLDSFP 161
Cdd:pfam00743  81 MHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736  162 GINAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRIFDSGYPWDMVFMTRFQN 241
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736  242 MLRNSLPTPIVTWLMERKINNWLNHANYGLIPEDRTQLKEFVLNDELPGRIITGKVFIRPSIKE---------------- 305
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEftetsaifedgtveed 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736  306 -------------------SVVKVEDGQASLYKYIFPAHLQKPTLAIIGLIKPLGSMIPTGETQARWAVRVLKGVNKLPP 366
Cdd:pfam00743 321 idvvifatgytfafpfleeSLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPS 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736  367 PSVMIEEINARKENKPSWFGLCYCKALQSDYITYIDELLTYINAKPNLFSMLLTDPHLALTVFFGPCSPYQFRLTGPGKW 446
Cdd:pfam00743 401 QSEMMAEINKRQEKKIKRFGDSQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKW 480

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 578800736  447 EGARNAIMTQWDRTFKVIKARVVQESPSPFESF-LKVFSFLALLVAIFLIF 496
Cdd:pfam00743 481 EGARNAILTQWDRILKPLKTRVVEKSSSPASSFtLKIFGLPVVLVAIFLIL 531
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 4-359 7.00e-68

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 223.59  E-value: 7.00e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736   4 RVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEhveegraslYKSVVSNSCKEMSCYSDFPFPEDYPNYVP 83
Cdd:COG2072    8 DVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRDNR---------YPGLRLDTPSHLYSLPFFPNWSDDPDFPT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736  84 NSQFLEYLKMYANHFDLLKHIQFKTKVCSVTKCSDSavsGQWEVVTmheEKQESAIFDAVMVCTGFLTNPYLPldSFPGI 163
Cdd:COG2072   79 GDEILAYLEAYADKFGLRRPIRFGTEVTSARWDEAD---GRWTVTT---DDGETLTARFVVVATGPLSRPKIP--DIPGL 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736 164 NAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRifdSGYPWDmvfMTRFQNML 243
Cdd:COG2072  151 EDFAGEQLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPR---PNYDPE---RGRPANYL 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736 244 RNSLPTPI----VTWLMERKINNWLNHANYGLIPEDRTQL-KEFVLNDEL------------PGRI--ITGKVfIR---- 300
Cdd:COG2072  225 GLEAPPALnrrdARAWLRRLLRAQVKDPELGLLTPDYPPGcKRPLLSTDYyealrrgnvelvTGGIerITEDG-VVfadg 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736 301 ------------------PSIKESVVKVEDGQAS--LYKYIFPAHLqkPTLAIIGLIKPLG--SMIPTGETQARWAVRVL 358
Cdd:COG2072  304 tehevdvivwatgfradlPWLAPLDVRGRDGRSGprAYLGVVVPGF--PNLFFLGPNSPSGhsSLTLGAERQARYIARLI 381


                 .
gi 578800736 359 K 359
Cdd:COG2072  382 A 382
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 2-404 2.46e-35

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 137.30  E-value: 2.46e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736   2 AKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEHVEEG-----------RASLYKSVVSNSCKEMSCYS 70
Cdd:PLN02172  10 SQHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYTPKSESDplsldptrsivHSSVYESLRTNLPRECMGYR 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736  71 DFPF----------PEDYPNYvpnSQFLEYLKMYANHFDLLKHIQFKTKVCSVtkcsdSAVSGQWEVVTMHEEK-QESAI 139
Cdd:PLN02172  90 DFPFvprfddesrdSRRYPSH---REVLAYLQDFAREFKIEEMVRFETEVVRV-----EPVDGKWRVQSKNSGGfSKDEI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736 140 FDAVMVCTGFLTNPYLPldSFPGINAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSttgggw 219
Cdd:PLN02172 162 FDAVVVCNGHYTEPNVA--HIPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIA------ 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736 220 viSRIFDSGypwdmvfmtrfqnmLRNSLPTPivtwlmerkINNWLNHANYGLIPEDrtqlkefvlndelpGRII--TGKV 297
Cdd:PLN02172 234 --SRASESD--------------TYEKLPVP---------QNNLWMHSEIDTAHED--------------GSIVfkNGKV 274

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736 298 FIRPSI--------------KESVVKVEDGQAS-LYKYIFPAHLqKPTLAIIGLiKPLGSMIPTGETQARWAVRVLKGVN 362
Cdd:PLN02172 275 VYADTIvhctgykyhfpfleTNGYMRIDENRVEpLYKHVFPPAL-APGLSFIGL-PAMGIQFVMFEIQSKWVAAVLSGRV 352

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 578800736 363 KLPPPSVMIEEINARKENKPSwFGLC--YCKAL---QSDYITYIDEL 404
Cdd:PLN02172 353 TLPSEDKMMEDINAWYASLEA-LGIPkrYTHKLgkiQSEYLNWIAEE 398
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 2-496 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 941.13  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736    2 AKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEHVEEGRASLYKSVVSNSCKEMSCYSDFPFPEDYPNY 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736   82 VPNSQFLEYLKMYANHFDLLKHIQFKTKVCSVTKCSDSAVSGQWEVVTMHEEKQESAIFDAVMVCTGFLTNPYLPLDSFP 161
Cdd:pfam00743  81 MHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736  162 GINAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRIFDSGYPWDMVFMTRFQN 241
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736  242 MLRNSLPTPIVTWLMERKINNWLNHANYGLIPEDRTQLKEFVLNDELPGRIITGKVFIRPSIKE---------------- 305
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEftetsaifedgtveed 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736  306 -------------------SVVKVEDGQASLYKYIFPAHLQKPTLAIIGLIKPLGSMIPTGETQARWAVRVLKGVNKLPP 366
Cdd:pfam00743 321 idvvifatgytfafpfleeSLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPS 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736  367 PSVMIEEINARKENKPSWFGLCYCKALQSDYITYIDELLTYINAKPNLFSMLLTDPHLALTVFFGPCSPYQFRLTGPGKW 446
Cdd:pfam00743 401 QSEMMAEINKRQEKKIKRFGDSQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKW 480

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|.
gi 578800736  447 EGARNAIMTQWDRTFKVIKARVVQESPSPFESF-LKVFSFLALLVAIFLIF 496
Cdd:pfam00743 481 EGARNAILTQWDRILKPLKTRVVEKSSSPASSFtLKIFGLPVVLVAIFLIL 531
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 4-359 7.00e-68

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 223.59  E-value: 7.00e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736   4 RVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEhveegraslYKSVVSNSCKEMSCYSDFPFPEDYPNYVP 83
Cdd:COG2072    8 DVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRDNR---------YPGLRLDTPSHLYSLPFFPNWSDDPDFPT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736  84 NSQFLEYLKMYANHFDLLKHIQFKTKVCSVTKCSDSavsGQWEVVTmheEKQESAIFDAVMVCTGFLTNPYLPldSFPGI 163
Cdd:COG2072   79 GDEILAYLEAYADKFGLRRPIRFGTEVTSARWDEAD---GRWTVTT---DDGETLTARFVVVATGPLSRPKIP--DIPGL 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736 164 NAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGGWVISRifdSGYPWDmvfMTRFQNML 243
Cdd:COG2072  151 EDFAGEQLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPR---PNYDPE---RGRPANYL 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736 244 RNSLPTPI----VTWLMERKINNWLNHANYGLIPEDRTQL-KEFVLNDEL------------PGRI--ITGKVfIR---- 300
Cdd:COG2072  225 GLEAPPALnrrdARAWLRRLLRAQVKDPELGLLTPDYPPGcKRPLLSTDYyealrrgnvelvTGGIerITEDG-VVfadg 303

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736 301 ------------------PSIKESVVKVEDGQAS--LYKYIFPAHLqkPTLAIIGLIKPLG--SMIPTGETQARWAVRVL 358
Cdd:COG2072  304 tehevdvivwatgfradlPWLAPLDVRGRDGRSGprAYLGVVVPGF--PNLFFLGPNSPSGhsSLTLGAERQARYIARLI 381


                 .
gi 578800736 359 K 359
Cdd:COG2072  382 A 382
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 2-404 2.46e-35

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 137.30  E-value: 2.46e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736   2 AKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFTEHVEEG-----------RASLYKSVVSNSCKEMSCYS 70
Cdd:PLN02172  10 SQHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYTPKSESDplsldptrsivHSSVYESLRTNLPRECMGYR 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736  71 DFPF----------PEDYPNYvpnSQFLEYLKMYANHFDLLKHIQFKTKVCSVtkcsdSAVSGQWEVVTMHEEK-QESAI 139
Cdd:PLN02172  90 DFPFvprfddesrdSRRYPSH---REVLAYLQDFAREFKIEEMVRFETEVVRV-----EPVDGKWRVQSKNSGGfSKDEI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736 140 FDAVMVCTGFLTNPYLPldSFPGINAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSttgggw 219
Cdd:PLN02172 162 FDAVVVCNGHYTEPNVA--HIPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIA------ 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736 220 viSRIFDSGypwdmvfmtrfqnmLRNSLPTPivtwlmerkINNWLNHANYGLIPEDrtqlkefvlndelpGRII--TGKV 297
Cdd:PLN02172 234 --SRASESD--------------TYEKLPVP---------QNNLWMHSEIDTAHED--------------GSIVfkNGKV 274

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736 298 FIRPSI--------------KESVVKVEDGQAS-LYKYIFPAHLqKPTLAIIGLiKPLGSMIPTGETQARWAVRVLKGVN 362
Cdd:PLN02172 275 VYADTIvhctgykyhfpfleTNGYMRIDENRVEpLYKHVFPPAL-APGLSFIGL-PAMGIQFVMFEIQSKWVAAVLSGRV 352

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 578800736 363 KLPPPSVMIEEINARKENKPSwFGLC--YCKAL---QSDYITYIDEL 404
Cdd:PLN02172 353 TLPSEDKMMEDINAWYASLEA-LGIPkrYTHKLgkiQSEYLNWIAEE 398
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
72-219 2.02e-15

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 76.88  E-value: 2.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736   72 FPFPEDYPNyvpNSQFLEYLKMYANHFDLlkHIQFKTKVCSVTKcsdsaVSGQWEVVTMHEEkqesaiFDA--VMVCTGF 149
Cdd:pfam13738  65 FTFNREHPS---GNEYAEYLRRVADHFEL--PINLFEEVTSVKK-----EDDGFVVTTSKGT------YQAryVIIATGE 128

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578800736  150 LTNPYLPLDSFPGInafkgqyfHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEashLAEK---VFLSTTGGGW 219
Cdd:pfam13738 129 FDFPNKLGVPELPK--------HYSYVKDFHPYAGQKVVVIGGYNSAVDAALE---LVRKgarVTVLYRGSEW 190
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 3-203 6.46e-07

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 51.67  E-value: 6.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736   3 KRVAIVGAGVSGLAsikcC----LEEGLEPTCFERSDDLGGLWRF--TEHveegRasLYKSVVSnscKEMscysdfpfpe 76
Cdd:COG0493  122 KKVAVVGSGPAGLA----AayqlARAGHEVTVFEALDKPGGLLRYgiPEF----R--LPKDVLD---REI---------- 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736  77 dypnyvpnsQFLEylKMyanhfdllkHIQFKTKVcsvtkcsdsavsgqwEV---VTMHEEKQEsaiFDAVMVCTGFLTNP 153
Cdd:COG0493  179 ---------ELIE--AL---------GVEFRTNV---------------EVgkdITLDELLEE---FDAVFLATGAGKPR 220

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 578800736 154 YLPLdsfPGINAfKGQYF------HSRQYKHPD--IFKDKRVLVIGMGNSGTDIAVEA 203
Cdd:COG0493  221 DLGI---PGEDL-KGVHSamdfltAVNLGEAPDtiLAVGKRVVVIGGGNTAMDCARTA 274
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
5-212 6.77e-06

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 47.81  E-value: 6.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736   5 VAIVGAGVSGL-ASIKCCLEeGLEPTCFERsDDLGGLWRFTEHVEegraslyksvvsnsckemscysDFP-FPEDypnyV 82
Cdd:COG0492    3 VVIIGAGPAGLtAAIYAARA-GLKTLVIEG-GEPGGQLATTKEIE----------------------NYPgFPEG----I 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736  83 PNSQFLEYLKMYANHFDllkhIQFK-TKVCSVTKcsdsaVSGQWEVVTmheEKQESAIFDAVMVCTGFltNP-YLPLdsf 160
Cdd:COG0492   55 SGPELAERLREQAERFG----AEILlEEVTSVDK-----DDGPFRVTT---DDGTEYEAKAVIIATGA--GPrKLGL--- 117

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578800736 161 PGINAFKGQ----------YFhsrqykhpdiFKDKRVLVIGMGNSGTDIAVEASHLAEKVFL 212
Cdd:COG0492  118 PGEEEFEGRgvsycatcdgFF----------FRGKDVVVVGGGDSALEEALYLTKFASKVTL 169
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 3-198 1.22e-05

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 47.47  E-value: 1.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736   3 KRVAIVGAGVSGLAsikcCLEE----GLEPTCFERSDDLGGLWRFtehveeGRAS--LYKSVVSNSCKEMScysdfpfpe 76
Cdd:PRK12810 144 KKVAVVGSGPAGLA----AADQlaraGHKVTVFERADRIGGLLRY------GIPDfkLEKEVIDRRIELME--------- 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736  77 dypnyvpnsqfleylKMyanhfdllkHIQFKTKVcsvtkcsdsavsgqwEV---VTMHEEKQEsaiFDAVMVCTGfLTNP 153
Cdd:PRK12810 205 ---------------AE---------GIEFRTNV---------------EVgkdITAEELLAE---YDAVFLGTG-AYKP 241

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 578800736 154 -YLPldsFPGINAfKGQYF-----------HSRQYKHPDI-FKDKRVLVIGMGNSGTD 198
Cdd:PRK12810 242 rDLG---IPGRDL-DGVHFamdfliqntrrVLGDETEPFIsAKGKHVVVIGGGDTGMD 295
PRK12770 PRK12770
putative glutamate synthase subunit beta; Provisional
 3-213 1.36e-05

putative glutamate synthase subunit beta; Provisional


Pssm-ID: 237197 [Multi-domain]  Cd Length: 352  Bit Score: 47.29  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736   3 KRVAIVGAGVSGLAS---IKCcleEGLEPTCFERSDDLGGLWRFT--------EHVEEGRASLYKSVVSNSCKEMSCYSD 71
Cdd:PRK12770  19 KKVAIIGAGPAGLAAagyLAC---LGYEVHVYDKLPEPGGLMLFGipefripiERVREGVKELEEAGVVFHTRTKVCCGE 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736  72 FPFPEDypnyvpnsqfleylkmyANHFdllkhiqfktkVCSVTKCSDsavsgqwevvtMHEEkqesaiFDAVMVCTGF-- 149
Cdd:PRK12770  96 PLHEEE-----------------GDEF-----------VERIVSLEE-----------LVKK------YDAVLIATGTwk 130

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578800736 150 ---LTNP-------YLPLDSFPGINAFKgqYFHSRQYKHPDiFKDKRVLVIGMGNSGTDIAVEASHL-AEKVFLS 213
Cdd:PRK12770 131 srkLGIPgedlpgvYSALEYLFRIRAAK--LGYLPWEKVPP-VEGKKVVVVGAGLTAVDAALEAVLLgAEKVYLA 202
Lys_Orn_oxgnase pfam13434
L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold ...
 81-199 1.73e-05

L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase; This is a family of Rossmann fold oxidoreductases that catalyze NADPH-dependent hydroxylation and are involved in siderophore biosynthesis. This family includes L-ornithine 5-monooxygenase, which catalyzes the hydroxylation of L-ornithine at the N5 position, and L-lysine 6-monooxygenase, which catalyzes the hydroxylation of lysine at the N6 position (EC:1.14.13.59).


Pssm-ID: 433204 [Multi-domain]  Cd Length: 338  Bit Score: 46.81  E-value: 1.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800736   81 YVPNSQFLEYLKMYANHFDllKHIQFKTKVCSVTKcSDSAVSGQWEVVTMHEEKQESAIF-DAVMVCTGflTNPYLPlDS 159
Cdd:pfam13434  91 FPSRREFNDYLQWAASHLP--NRLRFGQEVESVEP-DAERGEPLLRVRVRDADGEETTFLaRNLVLGTG--GEPYIP-EC 164

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 578800736  160 FPGinafKGQYFHSRQY--KHPDIFKDKRVLVIGMGNSGTDI 199
Cdd:pfam13434 165 ARG----GERVFHSSEYleRIDRLAAKKRIAVVGSGQSAAEI 202
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 3-40 2.07e-05

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 46.75  E-value: 2.07e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 578800736   3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGL 40
Cdd:COG1232    2 KRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVGGL 39
PRK07233 PRK07233
hypothetical protein; Provisional
 4-40 4.87e-05

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 45.65  E-value: 4.87e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 578800736   4 RVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGL 40
Cdd:PRK07233   1 KIAIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLGGL 37
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 1-39 1.53e-04

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 44.07  E-value: 1.53e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 578800736   1 MAKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGG 39
Cdd:COG3349    2 MPPRVVVVGGGLAGLAAAVELAEAGFRVTLLEARPRLGG 40
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
7-42 2.49e-04

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 39.44  E-value: 2.49e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578800736    7 IVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWR 42
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNAY 36
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 3-43 3.99e-04

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 43.20  E-value: 3.99e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 578800736   3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRF 43
Cdd:PRK12769 328 KRVAIIGAGPAGLACADVLARNGVAVTVYDRHPEIGGLLTF 368
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 3-36 2.61e-03

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 40.06  E-value: 2.61e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 578800736   3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDD 36
Cdd:COG0771    5 KKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPA 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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