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Conserved domains on  [gi|578800591|ref|XP_006711248|]
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leucine-rich repeat-containing protein 71 isoform X2 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 111-279 7.08e-21

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 95.24  E-value: 7.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800591 111 KSVKEIYIRGWKVEERILGVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLcSSTLRKVSLEGNPLPEQSYH---K 187
Cdd:COG5238  180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKG-NKSLTTLDLSNNQIGDEGVIalaE 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800591 188 LMALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQD 267
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQG----NTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGA 334

                        170
                 ....*....|..
gi 578800591 268 KGALKLAEVLRA 279
Cdd:COG5238  335 QGAIALAKALQE 346
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 111-279 7.08e-21

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 95.24  E-value: 7.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800591 111 KSVKEIYIRGWKVEERILGVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLcSSTLRKVSLEGNPLPEQSYH---K 187
Cdd:COG5238  180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKG-NKSLTTLDLSNNQIGDEGVIalaE 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800591 188 LMALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQD 267
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQG----NTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGA 334

                        170
                 ....*....|..
gi 578800591 268 KGALKLAEVLRA 279
Cdd:COG5238  335 QGAIALAKALQE 346
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 134-281 9.06e-15

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 75.47  E-value: 9.06e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800591 134 CLPPLTQLQainLWKVGLTDKTLTTFIELLPLcSSTLRKVSLEGNPLPEQSYHKL---MALDSTIAHLSLRNNNIDDRGA 210
Cdd:cd00116  135 LPPALEKLV---LGRNRLEGASCEALAKALRA-NRDLKELNLANNGIGDAGIRALaegLKANCNLEVLDLNNNGLTDEGA 210

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578800591 211 QLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLR-LNRSLLWLSLAHNRIQDKGALKLAEVLRAFE 281
Cdd:cd00116  211 SALAETLAS----LKSLEVLNLGDNNLTDAGAAALASALLsPNISLLTLSLSCNDITDDGAKDLAEVLAEKE 278
LRR_6 pfam13516
Leucine Rich repeat;
224-246 2.98e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 37.99  E-value: 2.98e-04
                          10        20
                  ....*....|....*....|...
gi 578800591  224 NRTLVSLNLGFNHIGDEGAGYIA 246
Cdd:pfam13516   2 NTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
252-279 5.41e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 37.39  E-value: 5.41e-04
                           10        20
                   ....*....|....*....|....*...
gi 578800591   252 NRSLLWLSLAHNRIQDKGALKLAEVLRA 279
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 111-279 7.08e-21

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 95.24  E-value: 7.08e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800591 111 KSVKEIYIRGWKVEERILGVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLcSSTLRKVSLEGNPLPEQSYH---K 187
Cdd:COG5238  180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKG-NKSLTTLDLSNNQIGDEGVIalaE 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800591 188 LMALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQD 267
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQG----NTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGA 334

                        170
                 ....*....|..
gi 578800591 268 KGALKLAEVLRA 279
Cdd:COG5238  335 QGAIALAKALQE 346
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 110-277 7.09e-16

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 79.83  E-value: 7.09e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800591 110 SKSVKEIYIRGWKVEERILGVFSKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLcSSTLRKVSLEGNPLPEQ---SYH 186
Cdd:COG5238  207 NTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKN-NTTVETLYLSGNQIGAEgaiALA 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800591 187 KLMALDSTIAHLSLRNNNIDDRGAQLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQ 266
Cdd:COG5238  286 KALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG----NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIG 361

                        170
                 ....*....|.
gi 578800591 267 DKGALKLAEVL 277
Cdd:COG5238  362 DEGAIALAKYL 372
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 134-281 9.06e-15

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 75.47  E-value: 9.06e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800591 134 CLPPLTQLQainLWKVGLTDKTLTTFIELLPLcSSTLRKVSLEGNPLPEQSYHKL---MALDSTIAHLSLRNNNIDDRGA 210
Cdd:cd00116  135 LPPALEKLV---LGRNRLEGASCEALAKALRA-NRDLKELNLANNGIGDAGIRALaegLKANCNLEVLDLNNNGLTDEGA 210

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578800591 211 QLLGQALSTlhscNRTLVSLNLGFNHIGDEGAGYIADGLR-LNRSLLWLSLAHNRIQDKGALKLAEVLRAFE 281
Cdd:cd00116  211 SALAETLAS----LKSLEVLNLGDNNLTDAGAAALASALLsPNISLLTLSLSCNDITDDGAKDLAEVLAEKE 278
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 132-280 1.46e-12

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 68.54  E-value: 1.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800591 132 SKCLPPLTQLQAINLWKVGLTDKTLTTFIELLPLcSSTLRKVSLEGNPLPEQSYHKL-MALDSTIA--HLSLRNNNIDDR 208
Cdd:cd00116  158 AKALRANRDLKELNLANNGIGDAGIRALAEGLKA-NCNLEVLDLNNNGLTDEGASALaETLASLKSleVLNLGDNNLTDA 236

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578800591 209 GAQLLGQALSTLhscNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLRAF 280
Cdd:cd00116  237 GAAALASALLSP---NISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEP 305
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 135-278 1.92e-10

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 62.37  E-value: 1.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800591 135 LPPLTQLQAINLWKVGLTD-------KTLTTFIELLPLCSST----------------------LRKVSLEGNPLPEQSY 185
Cdd:cd00116   19 LPKLLCLQVLRLEGNTLGEeaakalaSALRPQPSLKELCLSLnetgriprglqsllqgltkgcgLQELDLSDNALGPDGC 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800591 186 HKLMAL--DSTIAHLSLRNNNIDDRGAQLLGQAL-------------------------STLHSCNRTLVSLNLGFNHIG 238
Cdd:cd00116   99 GVLESLlrSSSLQELKLNNNGLGDRGLRLLAKGLkdlppaleklvlgrnrlegascealAKALRANRDLKELNLANNGIG 178

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 578800591 239 DEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR 278
Cdd:cd00116  179 DAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLA 218
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 191-278 2.65e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 62.50  E-value: 2.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800591 191 LDSTIAHLSLRNNNIDDRGAQLLGQALS---TLHSC---------------------NRTLVSLNLGFNHIGDEGAGYIA 246
Cdd:COG5238  178 QNNSVETVYLGCNQIGDEGIEELAEALTqntTVTTLwlkrnpigdegaeilaealkgNKSLTTLDLSNNQIGDEGVIALA 257

                         90       100       110
                 ....*....|....*....|....*....|..
gi 578800591 247 DGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR 278
Cdd:COG5238  258 EALKNNTTVETLYLSGNQIGAEGAIALAKALQ 289
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 209-278 2.40e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.71  E-value: 2.40e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800591 209 GAQLLGQALSTLHSCNRTLVSLNLGFNHIGDEGAGYIADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLR 278
Cdd:COG5238  164 RLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALK 233
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
135-267 3.13e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.47  E-value: 3.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800591 135 LPPLTQLQAINLWKVGLTDktLTTFIELLPlcssTLRKVSLEGNplpeqsyhKLMALDSTIA------HLSLRNNNIDDr 208
Cdd:COG4886  132 LANLTNLKELDLSNNQLTD--LPEPLGNLT----NLKSLDLSNN--------QLTDLPEELGnltnlkELDLSNNQITD- 196

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 578800591 209 gaqlLGQALSTLHScnrtLVSLNLGFNHIGDegagyIADGLRLNRSLLWLSLAHNRIQD 267
Cdd:COG4886  197 ----LPEPLGNLTN----LEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQLTD 242
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
135-368 8.46e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 8.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800591 135 LPPLTQLQAINLWKVGLTDktLTTFIELLPlcssTLRKVSLEGNPLPEQSYH--KLMALDStiahLSLRNNNIDDrgaql 212
Cdd:COG4886  155 LGNLTNLKSLDLSNNQLTD--LPEELGNLT----NLKELDLSNNQITDLPEPlgNLTNLEE----LDLSGNQLTD----- 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578800591 213 LGQALSTLHScnrtLVSLNLGFNHIGDegagyiADGLRLNRSLLWLSLAHNRIQDKGALKLAEVLRAFELTHTEVVERRR 292
Cdd:COG4886  220 LPEPLANLTN----LETLDLSNNQLTD------LPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKL 289

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578800591 293 LLLEKGTQERSRSPSSSRHGDSKTDREKSQMVGISNSALVDKTDKTQTMKTPKGLGKKKEKSWELAKKEEKLGSGQ 368
Cdd:COG4886  290 KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTL 365
LRR_6 pfam13516
Leucine Rich repeat;
224-246 2.98e-04

Leucine Rich repeat;


Pssm-ID: 463907 [Multi-domain]  Cd Length: 24  Bit Score: 37.99  E-value: 2.98e-04
                          10        20
                  ....*....|....*....|...
gi 578800591  224 NRTLVSLNLGFNHIGDEGAGYIA 246
Cdd:pfam13516   2 NTHLTTLDLSDNDIGDEGAEALA 24
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
252-279 5.41e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 37.39  E-value: 5.41e-04
                           10        20
                   ....*....|....*....|....*...
gi 578800591   252 NRSLLWLSLAHNRIQDKGALKLAEVLRA 279
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
224-250 2.96e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 35.08  E-value: 2.96e-03
                           10        20
                   ....*....|....*....|....*..
gi 578800591   224 NRTLVSLNLGFNHIGDEGAGYIADGLR 250
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALK 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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