|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
255-669 |
8.91e-159 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 466.93 E-value: 8.91e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 255 TSFGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMDQRElkegDGPIGLIL 334
Cdd:COG0513 2 MSFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLDPSRP----RAPQALIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 335 APTRELSQQIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRM 414
Cdd:COG0513 78 APTRELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVETLVLDEADRM 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 415 FDMGFEPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRIVQGDVGEANADVTQHVIVFnnNPTGKWTwLLQN 494
Cdd:COG0513 158 LDMGFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLV--DKRDKLE-LLRR 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 495 LIEFLSAGSLLIFVTKKLNAEELANNLKLKEFDVLLLHGDMDQIERNKVITAFKKKEVSTLVATDVAARGLDIPHIRTVL 574
Cdd:COG0513 235 LLRDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVI 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 575 NYDVARDIDTHTHRIGRTGRAGEKGTAYTLVTEKDKefagHLVRNLEGA-NQEVPKSLMDLAMQSAWFRKSRFKGGKGKS 653
Cdd:COG0513 315 NYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDER----RLLRAIEKLiGQKIEEEELPGFEPVEEKRLERLKPKIKEK 390
|
410
....*....|....*.
gi 571566319 654 LNVGGAGLGFRGRPEP 669
Cdd:COG0513 391 LKGKKAGRGGRPGPKG 406
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
200-655 |
1.77e-152 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 455.77 E-value: 1.77e-152
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 200 DPLPPIDHSEIQYESFEKNFYNVHDEIANLNKQQVDDLRKTLGIK-VSGPSPPNPVTSFGHFGFDDALIKAIRKNEYTQP 278
Cdd:PTZ00110 74 KRLQPIDWKSINLVPFEKNFYKEHPEVSALSSKEVDEIRKEKEITiIAGENVPKPVVSFEYTSFPDYILKSLKNAGFTEP 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 279 TPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMDQRELKEGDGPIGLILAPTRELSQQIYQEARKFGKVYNVQ 358
Cdd:PTZ00110 154 TPIQVQGWPIALSGRDMIGIAETGSGKTLAFLLPAIVHINAQPLLRYGDGPIVLVLAPTRELAEQIREQCNKFGASSKIR 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 359 VCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFDMGFEPQVRSICNHVRPDRQTLL 438
Cdd:PTZ00110 234 NTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLESNVTNLRRVTYLVLDEADRMLDMGFEPQIRKIVSQIRPDRQTLM 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 439 FSATFKKRVEKLARDVLTD-PVRIVQGDVG-EANADVTQHV-IVFNNNPTGKWTWLLQNLieFLSAGSLLIFVTKKLNAE 515
Cdd:PTZ00110 314 WSATWPKEVQSLARDLCKEePVHVNVGSLDlTACHNIKQEVfVVEEHEKRGKLKMLLQRI--MRDGDKILIFVETKKGAD 391
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 516 ELANNLKLKEFDVLLLHGDMDQIERNKVITAFKKKEVSTLVATDVAARGLDIPHIRTVLNYDVARDIDTHTHRIGRTGRA 595
Cdd:PTZ00110 392 FLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRA 471
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 596 GEKGTAYTLVTEKDKEFAGHLVRNLEGANQEVPKSLMDLAMQSAWFRKSRFKGGKGKSLN 655
Cdd:PTZ00110 472 GAKGASYTFLTPDKYRLARDLVKVLREAKQPVPPELEKLSNERSNGTERRRWGGYGRFSN 531
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
266-462 |
1.56e-136 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 401.41 E-value: 1.56e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 266 LIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMDQRELKEGDGPIGLILAPTRELSQQIY 345
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQRELEKGEGPIAVIVAPTRELAQQIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 346 QEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFDMGFEPQVRS 425
Cdd:cd17952 81 LEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMGFEYQVRS 160
|
170 180 190
....*....|....*....|....*....|....*..
gi 571566319 426 ICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRIV 462
Cdd:cd17952 161 IVGHVRPDRQTLLFSATFKKKIEQLARDILSDPIRVV 197
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
244-461 |
8.64e-110 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 333.19 E-value: 8.64e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 244 KVSGPSPPNPVTSFGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMDQREL 323
Cdd:cd17953 1 KVRGKDCPKPIQKWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKDQRPV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 324 KEGDGPIGLILAPTRELSQQIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKM---KATNL 400
Cdd:cd17953 81 KPGEGPIGLIMAPTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILTAnngRVTNL 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 571566319 401 TRVTFLVLDEADRMFDMGFEPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRI 461
Cdd:cd17953 161 RRVTYVVLDEADRMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPIEI 221
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
275-621 |
1.70e-105 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 331.00 E-value: 1.70e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 275 YTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHImDQRELkegdGPIGLILAPTRELSQQIYQEARKFGK- 353
Cdd:PRK11776 24 YTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKL-DVKRF----RVQALVLCPTRELADQVAKEIRRLARf 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 354 VYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFDMGFEPQVRSICNHVRPD 433
Cdd:PRK11776 99 IPNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDLDALNTLVLDEADRMLDMGFQDAIDAIIRQAPAR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 434 RQTLLFSATFKKRVEKLARDVLTDPVRiVQGDVGEANADVTQHVivFNNNPTGKWTWLLQNLIEFLSAgSLLIFVTKKLN 513
Cdd:PRK11776 179 RQTLLFSATYPEGIAAISQRFQRDPVE-VKVESTHDLPAIEQRF--YEVSPDERLPALQRLLLHHQPE-SCVVFCNTKKE 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 514 AEELANNLKLKEFDVLLLHGDMDQIERNKVITAFKKKEVSTLVATDVAARGLDIPHIRTVLNYDVARDIDTHTHRIGRTG 593
Cdd:PRK11776 255 CQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKALEAVINYELARDPEVHVHRIGRTG 334
|
330 340
....*....|....*....|....*...
gi 571566319 594 RAGEKGTAYTLVTEKDkefaGHLVRNLE 621
Cdd:PRK11776 335 RAGSKGLALSLVAPEE----MQRANAIE 358
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
266-461 |
2.51e-101 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 310.14 E-value: 2.51e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 266 LIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHImDQRELKEGDGPIGLILAPTRELSQQIY 345
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKL-LPEPKKKGRGPQALVLAPTRELAMQIA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 346 QEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFDMGFEPQVRS 425
Cdd:cd00268 80 EVARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMGFEEDVEK 159
|
170 180 190
....*....|....*....|....*....|....*.
gi 571566319 426 ICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRI 461
Cdd:cd00268 160 ILSALPKDRQTLLFSATLPEEVKELAKKFLKNPVRI 195
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
266-462 |
1.00e-100 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 308.91 E-value: 1.00e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 266 LIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMDQRELKEGDGPIGLILAPTRELSQQIY 345
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQPPLERGDGPIVLVLAPTRELAQQIQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 346 QEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFDMGFEPQVRS 425
Cdd:cd17966 81 QEANKFGGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLDMGFEPQIRK 160
|
170 180 190
....*....|....*....|....*....|....*..
gi 571566319 426 ICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRIV 462
Cdd:cd17966 161 IVDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYIQVN 197
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
255-621 |
1.95e-96 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 306.48 E-value: 1.95e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 255 TSFGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMDQRELKEGDGPIgLIL 334
Cdd:PRK11192 1 TTFSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDFPRRKSGPPRI-LIL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 335 APTRELSQQIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRM 414
Cdd:PRK11192 80 TPTRELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFDCRAVETLILDEADRM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 415 FDMGFEPQVRSICNHVRPDRQTLLFSATFK-KRVEKLARDVLTDPVRIvqgdvgEAN---------------ADVTQHvi 478
Cdd:PRK11192 160 LDMGFAQDIETIAAETRWRKQTLLFSATLEgDAVQDFAERLLNDPVEV------EAEpsrrerkkihqwyyrADDLEH-- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 479 vfnnnptgKwTWLLQNLIEFLSAGSLLIFVTKKLNAEELANNLKLKEFDVLLLHGDMDQIERNKVITAFKKKEVSTLVAT 558
Cdd:PRK11192 232 --------K-TALLCHLLKQPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVAT 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 571566319 559 DVAARGLDIPHIRTVLNYDVARDIDTHTHRIGRTGRAGEKGTAYTLVTEKDKEFAGHLVRNLE 621
Cdd:PRK11192 303 DVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISLVEAHDHLLLGKIERYIE 365
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
188-461 |
1.72e-91 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 287.68 E-value: 1.72e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 188 GNPIAIPKKK--EIDPLPpidhseiqyeSFEKNFYNVHDEIANLNKQQVDDLRKTLGIKVSGPSPPNPVTSFGHFGFDDA 265
Cdd:cd18050 3 GNPGERLRKKkwDLSELP----------KFEKNFYVEHPEVARMTQYDVEELRRKKEITIRGVGCPKPVFAFHQANFPQY 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 266 LIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMDQRELKEGDGPIGLILAPTRELSQQIY 345
Cdd:cd18050 73 VMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGDGPICLVLAPTRELAQQVQ 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 346 QEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFDMGFEPQVRS 425
Cdd:cd18050 153 QVADDYGKSSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRK 232
|
250 260 270
....*....|....*....|....*....|....*.
gi 571566319 426 ICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRI 461
Cdd:cd18050 233 IVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYVQI 268
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
232-461 |
2.38e-84 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 267.65 E-value: 2.38e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 232 QQVDDLRKTLGIKVSGPSPPNPVTSFGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIW 311
Cdd:cd18049 1 QEVEQYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 312 PMLVHIMDQRELKEGDGPIGLILAPTRELSQQIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIID 391
Cdd:cd18049 81 PAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLID 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 392 LVKMKATNLTRVTFLVLDEADRMFDMGFEPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRI 461
Cdd:cd18049 161 FLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHI 230
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
256-467 |
6.13e-81 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 257.80 E-value: 6.13e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 256 SFGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIM-DQRELKEGDG----PI 330
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLLeDGPPSVGRGRrkayPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 331 GLILAPTRELSQQIYQEARKFgkVYN--VQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVL 408
Cdd:cd17967 81 ALILAPTRELAIQIYEEARKF--SYRsgVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISLSSIKFLVL 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 571566319 409 DEADRMFDMGFEPQVRSICNH----VRPDRQTLLFSATFKKRVEKLARDVLTDPVRIVQGDVG 467
Cdd:cd17967 159 DEADRMLDMGFEPQIRKIVEHpdmpPKGERQTLMFSATFPREIQRLAADFLKNYIFLTVGRVG 221
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
199-467 |
1.85e-78 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 252.97 E-value: 1.85e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 199 IDPLPPIDHSEIqYESFEK--NFyNVHDEIAnlnkqqvddlrktlgIKVSGPSPPNPVTSFGHFGFDDALIKAIRKNEYT 276
Cdd:cd18052 2 IPPPPPEDEDEI-FATIQTgiNF-DKYDEIP---------------VEVTGRNPPPAILTFEEANLCETLLKNIRKAGYE 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 277 QPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMDQR----ELKEGDGPIGLILAPTRELSQQIYQEARKFG 352
Cdd:cd18052 65 KPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGMMKEGltasSFSEVQEPQALIVAPTRELANQIFLEARKFS 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 353 KVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFDMGFEPQVRSICNHV-- 430
Cdd:cd18052 145 YGTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGKISLSKLKYLILDEADRMLDMGFGPEIRKLVSEPgm 224
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 571566319 431 --RPDRQTLLFSATFKKRVEKLARDVL-TDPVRIVQGDVG 467
Cdd:cd18052 225 psKEDRQTLMFSATFPEEIQRLAAEFLkEDYLFLTVGRVG 264
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
256-605 |
5.35e-78 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 258.58 E-value: 5.35e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 256 SFGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMDQRELKEGDGPI-GLIL 334
Cdd:PRK10590 2 SFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAKGRRPVrALIL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 335 APTRELSQQIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRM 414
Cdd:PRK10590 82 TPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDEADRM 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 415 FDMGFEPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRIVQGDVGEANADVTQHVIVFNNNPTGKwtwLLQN 494
Cdd:PRK10590 162 LDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQHVHFVDKKRKRE---LLSQ 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 495 LIEFLSAGSLLIFVTKKLNAEELANNLKLKEFDVLLLHGDMDQIERNKVITAFKKKEVSTLVATDVAARGLDIPHIRTVL 574
Cdd:PRK10590 239 MIGKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVV 318
|
330 340 350
....*....|....*....|....*....|.
gi 571566319 575 NYDVARDIDTHTHRIGRTGRAGEKGTAYTLV 605
Cdd:PRK10590 319 NYELPNVPEDYVHRIGRTGRAAATGEALSLV 349
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
229-633 |
9.12e-77 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 257.02 E-value: 9.12e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 229 LNKQQVDDLRKTLGIKVSGPSPPNPVTSFGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAA 308
Cdd:PLN00206 95 LSSSQAELLRRKLEIHVKGEAVPPPILSFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTAS 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 309 FIWPMLVHIMDQR--ELKEGDGPIGLILAPTRELSQQIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATP 386
Cdd:PLN00206 175 FLVPIISRCCTIRsgHPSEQRNPLAMVLTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYRIQQGVELIVGTP 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 387 GRIIDLVKMKATNLTRVTFLVLDEADRMFDMGFEPQVRSICNHVrPDRQTLLFSATFKKRVEKLARDVLTDPVRIVQGDV 466
Cdd:PLN00206 255 GRLIDLLSKHDIELDNVSVLVLDEVDCMLERGFRDQVMQIFQAL-SQPQVLLFSATVSPEVEKFASSLAKDIILISIGNP 333
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 467 GEANADVTQHVI-VFNNNPTGKWTWLLQNLIEFLSAGslLIFVTKKLNAEELANNL-KLKEFDVLLLHGDMDQIERNKVI 544
Cdd:PLN00206 334 NRPNKAVKQLAIwVETKQKKQKLFDILKSKQHFKPPA--VVFVSSRLGADLLANAItVVTGLKALSIHGEKSMKERREVM 411
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 545 TAFKKKEVSTLVATDVAARGLDIPHIRTVLNYDVARDIDTHTHRIGRTGRAGEKGTAYTLVTEKDKEFAGHLVRNLEGAN 624
Cdd:PLN00206 412 KSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMGEKGTAIVFVNEEDRNLFPELVALLKSSG 491
|
....*....
gi 571566319 625 QEVPKSLMD 633
Cdd:PLN00206 492 AAIPRELAN 500
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
250-609 |
6.43e-76 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 253.68 E-value: 6.43e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 250 PPNPVTSFGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAF---IWPMLVHIMDQRELKEG 326
Cdd:PRK01297 82 PQEGKTRFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFlisIINQLLQTPPPKERYMG 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 327 DgPIGLILAPTRELSQQIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGG-AEIVVATPGRIIDLVKMKATNLTRVTF 405
Cdd:PRK01297 162 E-PRALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARfCDILVATPGRLLDFNQRGEVHLDMVEV 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 406 LVLDEADRMFDMGFEPQVRSICNHVRP--DRQTLLFSATFKKRVEKLARDVLTDPVRIVQGDVGEANADVTQHVIVFNNN 483
Cdd:PRK01297 241 MVLDEADRMLDMGFIPQVRQIIRQTPRkeERQTLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHVYAVAGS 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 484 PTGKwtwLLQNLIEFLSAGSLLIFVTKKLNAEELANNLKLKEFDVLLLHGDMDQIERNKVITAFKKKEVSTLVATDVAAR 563
Cdd:PRK01297 321 DKYK---LLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGR 397
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 571566319 564 GLDIPHIRTVLNYDVARDIDTHTHRIGRTGRAGEKGTAYTLVTEKD 609
Cdd:PRK01297 398 GIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISFAGEDD 443
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
266-461 |
3.62e-75 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 242.61 E-value: 3.62e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 266 LIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMD---QRELKEGDGPIGLILAPTRELSQ 342
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRlppLDEETKDDGPYALILAPTRELAQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 343 QIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFDMGFEPQ 422
Cdd:cd17945 81 QIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMIDMGFEPQ 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 571566319 423 VRSICNHV-----RPD---------------RQTLLFSATFKKRVEKLARDVLTDPVRI 461
Cdd:cd17945 161 VTKILDAMpvsnkKPDteeaeklaasgkhryRQTMMFTATMPPAVEKIAKGYLRRPVVV 219
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
255-608 |
2.38e-74 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 247.58 E-value: 2.38e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 255 TSFGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMD--QRELKEGDGPIGL 332
Cdd:PRK04837 8 QKFSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLShpAPEDRKVNQPRAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 333 ILAPTRELSQQIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEAD 412
Cdd:PRK04837 88 IMAPTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEAD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 413 RMFDMGFEPQVRSICNHVRP--DRQTLLFSATFKKRVEKLARDVLTDPvrivqgdvgeanadvtQHVIVFNNNPTGKWT- 489
Cdd:PRK04837 168 RMFDLGFIKDIRWLFRRMPPanQRLNMLFSATLSYRVRELAFEHMNNP----------------EYVEVEPEQKTGHRIk 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 490 ------------WLLQNLIEFLSAGSLLIFVTKKLNAEELANNLKLKEFDVLLLHGDMDQIERNKVITAFKKKEVSTLVA 557
Cdd:PRK04837 232 eelfypsneekmRLLQTLIEEEWPDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVA 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 571566319 558 TDVAARGLDIPHIRTVLNYDVARDIDTHTHRIGRTGRAGEKGTAYTLVTEK 608
Cdd:PRK04837 312 TDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISLACEE 362
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
255-621 |
4.10e-73 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 250.54 E-value: 4.10e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 255 TSFGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHImdQRELKegdGPIGLIL 334
Cdd:PRK11634 6 TTFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNL--DPELK---APQILVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 335 APTRELSQQIYQEARKFGK-VYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADR 413
Cdd:PRK11634 81 APTRELAVQVAEAMTDFSKhMRGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDEADE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 414 MFDMGFEPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDP--VRIvQGDVgEANADVTQHVivfnnnptgkwtWL 491
Cdd:PRK11634 161 MLRMGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPqeVRI-QSSV-TTRPDISQSY------------WT 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 492 LQN------LIEFLSA---GSLLIFVTKKLNAEELANNLKLKEFDVLLLHGDMDQIERNKVITAFKKKEVSTLVATDVAA 562
Cdd:PRK11634 227 VWGmrkneaLVRFLEAedfDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAA 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 571566319 563 RGLDIPHIRTVLNYDVARDIDTHTHRIGRTGRAGEKGTAYTLVTEKDKEfaghLVRNLE 621
Cdd:PRK11634 307 RGLDVERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALLFVENRERR----LLRNIE 361
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
253-608 |
1.23e-72 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 247.56 E-value: 1.23e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 253 PVT--SFGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMDQREL--KEGDG 328
Cdd:PRK04537 5 PLTdlTFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPALadRKPED 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 329 PIGLILAPTRELSQQIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKM-KATNLTRVTFLV 407
Cdd:PRK04537 85 PRALILAPTRELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQhKVVSLHACEICV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 408 LDEADRMFDMGFEPQVRSICNHV--RPDRQTLLFSATFKKRVEKLARDVLTDPVRIVQGDVGEANADVTQHvIVFNNNPT 485
Cdd:PRK04537 165 LDEADRMFDLGFIKDIRFLLRRMpeRGTRQTLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQR-IYFPADEE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 486 gKWTWLLqNLIEFLSAGSLLIFVTKKLNAEELANNLKLKEFDVLLLHGDMDQIERNKVITAFKKKEVSTLVATDVAARGL 565
Cdd:PRK04537 244 -KQTLLL-GLLSRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGL 321
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 571566319 566 DIPHIRTVLNYDVARDIDTHTHRIGRTGRAGEKGTAYTLVTEK 608
Cdd:PRK04537 322 HIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISFACER 364
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
266-462 |
1.02e-68 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 224.65 E-value: 1.02e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 266 LIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMDQRELKEG-DGPIGLILAPTRELSQQI 344
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPIPREQrNGPGVLVLTPTRELALQI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 345 YQEARKFgKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFDMGFEPQVR 424
Cdd:cd17958 81 EAECSKY-SYKGLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMGFEPQIR 159
|
170 180 190
....*....|....*....|....*....|....*...
gi 571566319 425 SICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRIV 462
Cdd:cd17958 160 KILLDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMIVY 197
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
256-461 |
3.52e-67 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 220.65 E-value: 3.52e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 256 SFGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMDQRElkegdGPIGLILA 335
Cdd:cd17954 1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENPQ-----RFFALVLA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 336 PTRELSQQIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIID-LVKMKATNLTRVTFLVLDEADRM 414
Cdd:cd17954 76 PTRELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDhLENTKGFSLKSLKFLVMDEADRL 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 571566319 415 FDMGFEPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRI 461
Cdd:cd17954 156 LNMDFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPVKI 202
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
243-467 |
2.76e-66 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 220.30 E-value: 2.76e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 243 IKVSGPSPPNPVTSFGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMDQ-- 320
Cdd:cd18051 9 VEATGENCPPHIETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIYEQgp 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 321 -RELKEGDG--------PIGLILAPTRELSQQIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIID 391
Cdd:cd18051 89 gESLPSESGyygrrkqyPLALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVD 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 392 LVKMKATNLTRVTFLVLDEADRMFDMGFEPQVRSIC--NHVRP--DRQTLLFSATFKKRVEKLARDVLTDPVRIVQGDVG 467
Cdd:cd18051 169 MLERGKIGLDYCKYLVLDEADRMLDMGFEPQIRRIVeqDTMPPtgERQTLMFSATFPKEIQMLARDFLDNYIFLAVGRVG 248
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
279-450 |
4.61e-64 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 210.95 E-value: 4.61e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 279 TPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHImdqreLKEGDGPIGLILAPTRELSQQIYQEARKFGKVYNVQ 358
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEAL-----DKLDNGPQALVLAPTRELAEQIYEELKKLGKGLGLK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 359 VCCCYGGGSKWEQSKALEGgAEIVVATPGRIIDLVKmKATNLTRVTFLVLDEADRMFDMGFEPQVRSICNHVRPDRQTLL 438
Cdd:pfam00270 76 VASLLGGDSRKEQLEKLKG-PDILVGTPGRLLDLLQ-ERKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILL 153
|
170
....*....|..
gi 571566319 439 FSATFKKRVEKL 450
Cdd:pfam00270 154 LSATLPRNLEDL 165
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
266-461 |
5.75e-64 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 212.20 E-value: 5.75e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 266 LIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMDQrELK----EGDGPIGLILAPTRELS 341
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFALEQ-EKKlpfiKGEGPYGLIVCPSRELA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 342 QQIYQEARKFGKVYN------VQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMF 415
Cdd:cd17951 80 RQTHEVIEYYCKALQeggypqLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRMI 159
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 571566319 416 DMGFEPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRI 461
Cdd:cd17951 160 DMGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVTV 205
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
266-464 |
1.15e-63 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 211.29 E-value: 1.15e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 266 LIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHImdqRELKEGDGPIGLILAPTRELSQQIY 345
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKL---GKPRKKKGLRALILAPTRELASQIY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 346 QEARKFGKVYNVQVCCCYGGGSKWEQSKALEG-GAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFDMGFEPQVR 424
Cdd:cd17957 78 RELLKLSKGTGLRIVLLSKSLEAKAKDGPKSItKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPGFREQTD 157
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 571566319 425 SI---CNHvrPDRQTLLFSATFKKRVEKLARDVLTDPVRIVQG 464
Cdd:cd17957 158 EIlaaCTN--PNLQRSLFSATIPSEVEELARSVMKDPIRIIVG 198
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
266-461 |
1.69e-62 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 207.88 E-value: 1.69e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 266 LIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLvhimdQREL---KEGDGPIGLILAPTRELSQ 342
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPIL-----ERLLyrpKKKAATRVLVLVPTRELAM 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 343 QIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVK-MKATNLTRVTFLVLDEADRMFDMGFEP 421
Cdd:cd17947 76 QCFSVLQQLAQFTDITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRnSPSFDLDSIEILVLDEADRMLEEGFAD 155
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 571566319 422 QVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRI 461
Cdd:cd17947 156 ELKEILRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPVRV 195
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
256-461 |
1.12e-61 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 206.00 E-value: 1.12e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 256 SFGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHimdqreLKEGDGPIG---L 332
Cdd:cd17959 2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEK------LKAHSPTVGaraL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 333 ILAPTRELSQQIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEAD 412
Cdd:cd17959 76 ILSPTRELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEAD 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 571566319 413 RMFDMGFEPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRI 461
Cdd:cd17959 156 RLFEMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVLI 204
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
254-634 |
5.69e-60 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 208.14 E-value: 5.69e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 254 VTSFGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHI-MDQRELKegdgpiGL 332
Cdd:PTZ00424 27 VDSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIdYDLNACQ------AL 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 333 ILAPTRELSQQIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEAD 412
Cdd:PTZ00424 101 ILAPTRELAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEAD 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 413 RMFDMGFEPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRIVQGDVGEANADVTQHVIVFNNNptgKWTW-L 491
Cdd:PTZ00424 181 EMLSRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVAVEKE---EWKFdT 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 492 LQNLIEFLSAGSLLIFVTKKLNAEELANNLKLKEFDVLLLHGDMDQIERNKVITAFKKKEVSTLVATDVAARGLDIPHIR 571
Cdd:PTZ00424 258 LCDLYETLTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVS 337
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 571566319 572 TVLNYDVARDIDTHTHRIGRTGRAGEKGTAYTLVTEKDKEFAGHLVRNLEGANQEVPKSLMDL 634
Cdd:PTZ00424 338 LVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDDIEQLKEIERHYNTQIEEMPMEVADY 400
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
257-459 |
1.23e-59 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 200.53 E-value: 1.23e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 257 FGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLvhimdQRELKEGDGPIGLILAP 336
Cdd:cd17955 1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPIL-----QRLSEDPYGIFALVLTP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 337 TRELSQQIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVK---MKATNLTRVTFLVLDEADR 413
Cdd:cd17955 76 TRELAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRssdDTTKVLSRVKFLVLDEADR 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 571566319 414 MFDMGFEPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPV 459
Cdd:cd17955 156 LLTGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPF 201
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
270-476 |
1.09e-56 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 192.32 E-value: 1.09e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 270 IRKNEYTQPTPIQAQAVPAALSG-RDIIGIAKTGSGKTAAFIWPMLVHimdqreLKEGDGPIGLILAPTRELSQQIYQEA 348
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEA------LKRGKGGRVLVLVPTRELAEQWAEEL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 349 RKFGKVYNVQVCCCYGGGSKWEQSKALEGG-AEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFDMGFEPQVRSIC 427
Cdd:smart00487 75 KKLGPSLGLKVVGLYGGDSKREQLRKLESGkTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKLL 154
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 571566319 428 NHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRIVQGDvgEANADVTQH 476
Cdd:smart00487 155 KLLPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVGF--TPLEPIEQF 201
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
262-455 |
1.42e-54 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 187.02 E-value: 1.42e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 262 FDDALIKAIRKNEYTQPTPIQAQAVPAALS-GRDIIGIAKTGSGKTAAFIWPMLVHIMDQRELKEGDGPIGLILAPTREL 340
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLLNTKPAGRRSGVSALIISPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 341 SQQIYQEARK---FGKVYNVQvcCCYGGGSKWEQSKALE-GGAEIVVATPGRIIDLVK--MKATNLTRVTFLVLDEADRM 414
Cdd:cd17964 81 ALQIAAEAKKllqGLRKLRVQ--SAVGGTSRRAELNRLRrGRPDILVATPGRLIDHLEnpGVAKAFTDLDYLVLDEADRL 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 571566319 415 FDMGFEPQVRSICNHVRP----DRQTLLFSATFKKRVEKLARDVL 455
Cdd:cd17964 159 LDMGFRPDLEQILRHLPEknadPRQTLLFSATVPDEVQQIARLTL 203
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
272-462 |
1.93e-52 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 181.24 E-value: 1.93e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 272 KNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIM-DQRELKEGDGPIGLILAPTRELSQQIYQEARK 350
Cdd:cd17949 8 KMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLsLEPRVDRSDGTLALVLVPTRELALQIYEVLEK 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 351 FGKVYNVQVCCCYGGGSKWEQSKA-LEGGAEIVVATPGRIID-LVKMKATNLTRVTFLVLDEADRMFDMGFEPQVRSICN 428
Cdd:cd17949 88 LLKPFHWIVPGYLIGGEKRKSEKArLRKGVNILIATPGRLLDhLKNTQSFDVSNLRWLVLDEADRLLDMGFEKDITKILE 167
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 571566319 429 HVR-------------PDRQTLLFSATFKKRVEKLARDVLTDPVRIV 462
Cdd:cd17949 168 LLDdkrskaggekskpSRRQTVLVSATLTDGVKRLAGLSLKDPVYID 214
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
268-461 |
8.24e-52 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 179.02 E-value: 8.24e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 268 KAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMDQReLKEGDGPIGLILAPTRELSQQIYQE 347
Cdd:cd17941 3 KGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLEKLYRER-WTPEDGLGALIISPTRELAMQIFEV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 348 ARKFGKVYNVQVCCCYGG-GSKWEQSKAleGGAEIVVATPGRIidLVKMKAT---NLTRVTFLVLDEADRMFDMGFEPQV 423
Cdd:cd17941 82 LRKVGKYHSFSAGLIIGGkDVKEEKERI--NRMNILVCTPGRL--LQHMDETpgfDTSNLQMLVLDEADRILDMGFKETL 157
|
170 180 190
....*....|....*....|....*....|....*...
gi 571566319 424 RSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRI 461
Cdd:cd17941 158 DAIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYI 195
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
473-605 |
6.10e-51 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 173.85 E-value: 6.10e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 473 VTQHVIVFNNNPtgKWTWLLQNLIEFLSAGSLLIFVTKKLNAEELANNLKLKEFDVLLLHGDMDQIERNKVITAFKKKEV 552
Cdd:cd18787 1 IKQLYVVVEEEE--KKLLLLLLLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKV 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 571566319 553 STLVATDVAARGLDIPHIRTVLNYDVARDIDTHTHRIGRTGRAGEKGTAYTLV 605
Cdd:cd18787 79 RVLVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
266-462 |
6.44e-51 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 176.61 E-value: 6.44e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 266 LIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLvHIMDQRELKEGDGPIG-LILAPTRELSQQI 344
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVL-EILLKRKANLKKGQVGaLIISPTRELATQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 345 YQEARKFGKVY-NVQVCCCYGGGSKWEQ--SKALEGGAEIVVATPGRIIDLVKMKAT--NLTRVTFLVLDEADRMFDMGF 419
Cdd:cd17960 80 YEVLQSFLEHHlPKLKCQLLIGGTNVEEdvKKFKRNGPNILVGTPGRLEELLSRKADkvKVKSLEVLVLDEADRLLDLGF 159
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 571566319 420 EPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRIV 462
Cdd:cd17960 160 EADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPVRVV 202
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
266-443 |
7.39e-51 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 177.82 E-value: 7.39e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 266 LIKAIRKNEYTQPTPIQAQAVPAALS-GRDIIGIAKTGSGKTAAFIWPMLVHIMDQRE----LKEGDGPIGLILAPTREL 340
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAIRdGKDVIGAAETGSGKTLAFGIPILERLLSQKSsngvGGKQKPLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 341 SQQIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMK---ATNLTRVTFLVLDEADRMFDM 417
Cdd:cd17946 81 AVQVKDHLKAIAKYTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGnehLANLKSLRFLVLDEADRMLEK 160
|
170 180 190
....*....|....*....|....*....|....
gi 571566319 418 G-FEpQVRSICNHV-------RPDRQTLLFSATF 443
Cdd:cd17946 161 GhFA-ELEKILELLnkdragkKRKRQTFVFSATL 193
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
257-461 |
4.07e-50 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 174.41 E-value: 4.07e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 257 FGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHImdqrELKEgDGPIGLILAP 336
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKI----DPKK-DVIQALILVP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 337 TRELSQQIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFD 416
Cdd:cd17940 76 TRELALQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEADKLLS 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 571566319 417 MGFEPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRI 461
Cdd:cd17940 156 QDFQPIIEKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPYEI 200
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
266-461 |
5.58e-49 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 170.81 E-value: 5.58e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 266 LIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVhimdqRELKEGDGPIGLILAPTRELSQQIY 345
Cdd:cd17962 1 LSSNLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPVII-----RCLTEHRNPSALILTPTRELAVQIE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 346 QEARKFGK-VYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFDMGFEPQVR 424
Cdd:cd17962 76 DQAKELMKgLPPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMGFQQQVL 155
|
170 180 190
....*....|....*....|....*....|....*..
gi 571566319 425 SICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRI 461
Cdd:cd17962 156 DILENISHDHQTILVSATIPRGIEQLAGQLLQNPVRI 192
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
268-452 |
5.38e-48 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 168.31 E-value: 5.38e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 268 KAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPmLVHIMDQRELKEGDGPIGLILAPTRELSQQIYQE 347
Cdd:cd17942 3 KAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIP-AIELLYKLKFKPRNGTGVIIISPTRELALQIYGV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 348 ARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTR-VTFLVLDEADRMFDMGFEPQVRSI 426
Cdd:cd17942 82 AKELLKYHSQTFGIVIGGANRKAEAEKLGKGVNILVATPGRLLDHLQNTKGFLYKnLQCLIIDEADRILEIGFEEEMRQI 161
|
170 180
....*....|....*....|....*.
gi 571566319 427 CNHVRPDRQTLLFSATFKKRVEKLAR 452
Cdd:cd17942 162 IKLLPKRRQTMLFSATQTRKVEDLAR 187
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
263-459 |
1.02e-47 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 167.76 E-value: 1.02e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 263 DDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMDQR-ELKEGDGPIGLILAPTRELS 341
Cdd:cd17961 2 DPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKaESGEEQGTRALILVPTRELA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 342 QQIYQEARKF-----GKVYNVQVCccyGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKAT-NLTRVTFLVLDEADRMF 415
Cdd:cd17961 82 QQVSKVLEQLtaycrKDVRVVNLS---ASSSDSVQRALLAEKPDIVVSTPARLLSHLESGSLlLLSTLKYLVIDEADLVL 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 571566319 416 DMGFEPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPV 459
Cdd:cd17961 159 SYGYEEDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPA 202
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
263-461 |
7.52e-46 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 162.36 E-value: 7.52e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 263 DDALIKAIRKNEYTQPTPIQAQAVPAALSG--RDIIGIAKTGSGKTAAFIWPMLVHImdQRELKEgdgPIGLILAPTREL 340
Cdd:cd17963 2 KPELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRV--DPTLKS---PQALCLAPTREL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 341 SQQIYQEARKFGKVYNVQVCCCYGGGSKWEQSKAlegGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFDM-GF 419
Cdd:cd17963 77 ARQIGEVVEKMGKFTGVKVALAVPGNDVPRGKKI---TAQIVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVMLDTqGH 153
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 571566319 420 EPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRI 461
Cdd:cd17963 154 GDQSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANTI 195
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
261-461 |
6.78e-44 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 157.10 E-value: 6.78e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 261 GFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHI-MDQRELKegdgpiGLILAPTRE 339
Cdd:cd17939 3 GLSEDLLRGIYAYGFEKPSAIQQRAIVPIIKGRDVIAQAQSGTGKTATFSIGALQRIdTTVRETQ------ALVLAPTRE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 340 LSQQIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFDMGF 419
Cdd:cd17939 77 LAQQIQKVVKALGDYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEMLSRGF 156
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 571566319 420 EPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRI 461
Cdd:cd17939 157 KDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPVRI 198
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
257-459 |
5.67e-42 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 151.70 E-value: 5.67e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 257 FGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMdqrelkegdgpiGLILAP 336
Cdd:cd17938 1 FEELGVMPELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIVV------------ALILEP 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 337 TRELSQQIYQEARKFGKVYN---VQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADR 413
Cdd:cd17938 69 SRELAEQTYNCIENFKKYLDnpkLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRFFVLDEADR 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 571566319 414 MFDMGFEPQVRSICNH-----VRPDR-QTLLFSATFKK-RVEKLARDVLTDPV 459
Cdd:cd17938 149 LLSQGNLETINRIYNRipkitSDGKRlQVIVCSATLHSfEVKKLADKIMHFPT 201
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
266-461 |
1.54e-40 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 147.41 E-value: 1.54e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 266 LIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLvhimdQRELKEGDGPIGLILAPTRELSQQIY 345
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIAL-----ESLDLERRHPQVLILAPTREIAVQIH 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 346 QEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFDMGFEPQVRS 425
Cdd:cd17943 76 DVFKKIGKKLEGLKCEVFIGGTPVKEDKKKLKGCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEGSFQKDVNW 155
|
170 180 190
....*....|....*....|....*....|....*..
gi 571566319 426 ICNHVRPDRQTLLFSATFKKRV-EKLARdVLTDPVRI 461
Cdd:cd17943 156 IFSSLPKNKQVIAFSATYPKNLdNLLAR-YMRKPVLV 191
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
254-461 |
1.16e-38 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 142.48 E-value: 1.16e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 254 VTSFGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLvhimdqRELKEGDGPIG-L 332
Cdd:cd17950 1 SSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTL------QQLEPVDGQVSvL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 333 ILAPTRELSQQIYQEARKFGK-VYNVQVCCCYGGGSKWEQSKALE-GGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDE 410
Cdd:cd17950 75 VICHTRELAFQISNEYERFSKyMPNVKTAVFFGGVPIKKDIEVLKnKCPHIVVGTPGRILALVREKKLKLSHVKHFVLDE 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 571566319 411 ADRMF-DMGFEPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRI 461
Cdd:cd17950 155 CDKMLeQLDMRRDVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPLEI 206
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
262-462 |
2.97e-38 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 141.04 E-value: 2.97e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 262 FDD-----ALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHImdQRELKEgdgPIGLILAP 336
Cdd:cd18046 1 FDDmnlkeSLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQI--DTSLKA---TQALVLAP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 337 TRELSQQIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFD 416
Cdd:cd18046 76 TRELAQQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADEMLS 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 571566319 417 MGFEPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRIV 462
Cdd:cd18046 156 RGFKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPIRIL 201
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
257-462 |
3.35e-37 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 138.37 E-value: 3.35e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 257 FGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHImdQRELKEgdgPIGLILAP 336
Cdd:cd18045 1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCL--DIQVRE---TQALILSP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 337 TRELSQQIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFD 416
Cdd:cd18045 76 TRELAVQIQKVLLALGDYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEADEMLN 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 571566319 417 MGFEPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRIV 462
Cdd:cd18045 156 KGFKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIRIL 201
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
267-452 |
1.02e-35 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 134.20 E-value: 1.02e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 267 IKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIM-DQRELKEGDGPIGLILAPTRELSQQIY 345
Cdd:cd17944 2 IKLLQARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQeDQQPRKRGRAPKVLVLAPTRELANQVT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 346 QEARKFGKvyNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFDMGFEPQVRS 425
Cdd:cd17944 82 KDFKDITR--KLSVACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFAEQVEE 159
|
170 180 190
....*....|....*....|....*....|...
gi 571566319 426 ICnHVR------PDRQTLLFSATFKKRVEKLAR 452
Cdd:cd17944 160 IL-SVSykkdseDNPQTLLFSATCPDWVYNVAK 191
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
266-465 |
6.01e-35 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 132.88 E-value: 6.01e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 266 LIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMDQRELKEG--DGPIGLILAPTRELSQQ 343
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLAEGpfNAPRGLVITPSRELAEQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 344 IYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFDMGFEPQV 423
Cdd:cd17948 81 IGSVAQSLTEGLGLKVKVITGGRTKRQIRNPHFEEVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLDDSFNEKL 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 571566319 424 RSICNH-----VRPDR--------QTLLFSATFKKRVEKLARDVL-TDPVRIVQGD 465
Cdd:cd17948 161 SHFLRRfplasRRSENtdgldpgtQLVLVSATMPSGVGEVLSKVIdVDSIETVTSD 216
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
491-596 |
6.51e-30 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 114.23 E-value: 6.51e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 491 LLQNLIEFLSAGSLLIFV--TKKLNAEELannLKLKEFDVLLLHGDMDQIERNKVITAFKKKEVSTLVATDVAARGLDIP 568
Cdd:pfam00271 5 ALLELLKKERGGKVLIFSqtKKTLEAELL---LEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLP 81
|
90 100
....*....|....*....|....*...
gi 571566319 569 HIRTVLNYDVARDIDTHTHRIGRTGRAG 596
Cdd:pfam00271 82 DVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
266-452 |
9.63e-30 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 117.73 E-value: 9.63e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 266 LIKAIRKNEYTQPTPIQAQAVPAALSG---------RDIIGIAKTGSGKTAAFIWPMLvhimdqRELKEGDGPI--GLIL 334
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPWLLPSskstppyrpGDLCVSAPTGSGKTLAYVLPIV------QALSKRVVPRlrALIV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 335 APTRELSQQIYQEARKFGKVYNVQVCCCYGGGSKWEQSKALEGG--------AEIVVATPGRIID-LVKMKATNLTRVTF 405
Cdd:cd17956 75 VPTKELVQQVYKVFESLCKGTGLKVVSLSGQKSFKKEQKLLLVDtsgrylsrVDILVATPGRLVDhLNSTPGFTLKHLRF 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 571566319 406 LVLDEADRMFDMGFE---PQV-RSICNHVRPDR----------------QTLLFSATFKKRVEKLAR 452
Cdd:cd17956 155 LVIDEADRLLNQSFQdwlETVmKALGRPTAPDLgsfgdanllersvrplQKLLFSATLTRDPEKLSS 221
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
515-596 |
8.64e-28 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 106.91 E-value: 8.64e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 515 EELANNLKLKEFDVLLLHGDMDQIERNKVITAFKKKEVSTLVATDVAARGLDIPHIRTVLNYDVARDIDTHTHRIGRTGR 594
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 571566319 595 AG 596
Cdd:smart00490 81 AG 82
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
264-462 |
7.00e-26 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 107.46 E-value: 7.00e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 264 DALIKAIRK-----NEYTQPTPIQAQAVPAAL---------------SGRDIIGIA-KTGSGKTAAFIWPMLVHIMDQ-R 321
Cdd:cd17965 12 EAIIKEILKgsnktDEEIKPSPIQTLAIKKLLktlmrkvtkqtsneePKLEVFLLAaETGSGKTLAYLAPLLDYLKRQeQ 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 322 ELKEGDGPI-----------GLILAPTRELSQQIYQEARKFGKV--YNVQVCCCYGGGSKWEQSKALEGGAEIVVATPGR 388
Cdd:cd17965 92 EPFEEAEEEyesakdtgrprSVILVPTHELVEQVYSVLKKLSHTvkLGIKTFSSGFGPSYQRLQLAFKGRIDILVTTPGK 171
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 571566319 389 IIDLVKMKATNLTRVTFLVLDEADRMFDMGFEPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDPVRIV 462
Cdd:cd17965 172 LASLAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATIPKEFDKTLRKLFPDVVRIA 245
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
243-458 |
4.37e-24 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 101.64 E-value: 4.37e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 243 IKVSGPSPPNP---VTSFGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSG--RDIIGIAKTGSGKTAAFIWPMLVHI 317
Cdd:cd18048 3 VEVLQRDPTSPlfsVKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 318 mDQRELKegdgPIGLILAPTRELSQQIYQEARKFGKVYN-VQVCCCYGGGskwEQSKALEGGAEIVVATPGRIID-LVKM 395
Cdd:cd18048 83 -DALKLY----PQCLCLSPTFELALQTGKVVEEMGKFCVgIQVIYAIRGN---RPGKGTDIEAQIVIGTPGTVLDwCFKL 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 571566319 396 KATNLTRVTFLVLDEADRMFDM-GFEPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDP 458
Cdd:cd18048 155 RLIDVTNISVFVLDEADVMINVqGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDP 218
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
271-616 |
5.10e-20 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 94.71 E-value: 5.10e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 271 RKNEYTQPTPIQAQAVPAALS-----GRDIIGIAKTGSGKTAafiwpMLVHIMdqRELKEGdGPIgLILAPTRELSQQIY 345
Cdd:COG1061 74 ASGTSFELRPYQQEALEALLAalergGGRGLVVAPTGTGKTV-----LALALA--AELLRG-KRV-LVLVPRRELLEQWA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 346 QEARKFGKVYNVqvcccyGGGSKweqskalEGGAEIVVATpgriIDLVKMKATNLT---RVTFLVLDEADRMFDMGFepq 422
Cdd:COG1061 145 EELRRFLGDPLA------GGGKK-------DSDAPITVAT----YQSLARRAHLDElgdRFGLVIIDEAHHAGAPSY--- 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 423 vRSICNHVRPDRqTLLFSAT------------------FKKRVEKLARD-VLTDPVRIV--------QGDVGEANADVTQ 475
Cdd:COG1061 205 -RRILEAFPAAY-RLGLTATpfrsdgreillflfdgivYEYSLKEAIEDgYLAPPEYYGirvdltdeRAEYDALSERLRE 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 476 HVIvfnNNPTGKWTWLLQNLIEFLSAGSLLIFVTKKLNAEELANNLKLKEFDVLLLHGDMDQIERNKVITAFKKKEVSTL 555
Cdd:COG1061 283 ALA---ADAERKDKILRELLREHPDDRKTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRIL 359
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 571566319 556 VATDVAARGLDIPHIRTVLnydVARDIDTHTH---RIGR---TGRAGEKGTAYTLVTEKDKEFAGHL 616
Cdd:COG1061 360 VTVDVLNEGVDVPRLDVAI---LLRPTGSPREfiqRLGRglrPAPGKEDALVYDFVGNDVPVLEELA 423
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
256-458 |
7.95e-20 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 88.62 E-value: 7.95e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 256 SFGHFGFDDALIKAIRKNEYTQPTPIQAQAVPAALSG--RDIIGIAKTGSGKTAAFIWPMLVHIMDQRELKEgdgpiGLI 333
Cdd:cd18047 2 SFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQ-----CLC 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 334 LAPTRELSQQIYQEARKFGKVYNvQVCCCYG-GGSKWEQSKALEGgaEIVVATPGRIID-LVKMKATNLTRVTFLVLDEA 411
Cdd:cd18047 77 LSPTYELALQTGKVIEQMGKFYP-ELKLAYAvRGNKLERGQKISE--QIVIGTPGTVLDwCSKLKFIDPKKIKVFVLDEA 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 571566319 412 DRMF-DMGFEPQVRSICNHVRPDRQTLLFSATFKKRVEKLARDVLTDP 458
Cdd:cd18047 154 DVMIaTQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDP 201
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
264-611 |
1.98e-18 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 89.18 E-value: 1.98e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 264 DALIKAIRKNEYTQPTPIQAQAVPAAL-SGRDIIGIAKTGSGKTA-AFIWpMLvhimdqRELKEGdgPIGLILAPTRELS 341
Cdd:COG1204 9 EKVIEFLKERGIEELYPPQAEALEAGLlEGKNLVVSAPTASGKTLiAELA-IL------KALLNG--GKALYIVPLRALA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 342 QQIYQEARKFGKVYNVQVCCCYGGgskWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEA------DRmf 415
Cdd:COG1204 80 SEKYREFKRDFEELGIKVGVSTGD---YDSDDEWLGRYDILVATPEKLDSLLRNGPSWLRDVDLVVVDEAhliddeSR-- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 416 dmGfePQVRSICNHVR---PDRQTLLFSATFKKrVEKLAR-----DVLTD--PVRIVQGdVgeanadVTQHVIVF---NN 482
Cdd:COG1204 155 --G--PTLEVLLARLRrlnPEAQIVALSATIGN-AEEIAEwldaeLVKSDwrPVPLNEG-V------LYDGVLRFddgSR 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 483 NPTGKWTWLLQNLIEflSAGSLLIFVTKKLNAEELANNL--------------KLKEFDVLLL----------------- 531
Cdd:COG1204 223 RSKDPTLALALDLLE--EGGQVLVFVSSRRDAESLAKKLadelkrrltpeereELEELAEELLevseethtnekladcle 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 532 ------HGDMDQIERNKVITAFKKKEVSTLVATDVAARGLDIPhIRTVlnydVARDIdthtHR--------------IGR 591
Cdd:COG1204 301 kgvafhHAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVNLP-ARRV----IIRDT----KRggmvpipvlefkqmAGR 371
|
410 420
....*....|....*....|..
gi 571566319 592 TGRAG--EKGTAYtLVTEKDKE 611
Cdd:COG1204 372 AGRPGydPYGEAI-LVAKSSDE 392
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
299-442 |
1.17e-15 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 74.75 E-value: 1.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 299 AKTGSGKT-AAFIWpmLVHIMDQRELKEgdgpigLILAPTRELSQQIYQEARK-FGKVYNVQVCccYGGGSKWEQSKALE 376
Cdd:cd00046 8 APTGSGKTlAALLA--ALLLLLKKGKKV------LVLVPTKALALQTAERLRElFGPGIRVAVL--VGGSSAEEREKNKL 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 571566319 377 GGAEIVVATPGRIIDLVK-MKATNLTRVTFLVLDEADRMFDMGFEPQV--RSICNHVRPDRQTLLFSAT 442
Cdd:cd00046 78 GDADIIIATPDMLLNLLLrEDRLFLKDLKLIIVDEAHALLIDSRGALIldLAVRKAGLKNAQVILLSAT 146
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
282-611 |
1.07e-10 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 64.78 E-value: 1.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 282 QAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLvhimdqreLKEGdgpIGLILAPTRELSQ-QIyQEARKFGkvynVQVC 360
Cdd:COG0514 22 QEEIIEAVLAGRDALVVMPTGGGKSLCYQLPAL--------LLPG---LTLVVSPLIALMKdQV-DALRAAG----IRAA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 361 CCYGGGSKWEQSKALE----GGAEIVVATP-----GRIIDLVKmkatnLTRVTFLVLDEA--------DrmfdmgFEPQV 423
Cdd:COG0514 86 FLNSSLSAEERREVLRalraGELKLLYVAPerllnPRFLELLR-----RLKISLFAIDEAhcisqwghD------FRPDY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 424 RSIcNHVR---PDRQTLLFSATFKKRV-----EKLArdvLTDPVRIVQGdvgeanadvtqhvivFN--N--------NPT 485
Cdd:COG0514 155 RRL-GELRerlPNVPVLALTATATPRVradiaEQLG---LEDPRVFVGS---------------FDrpNlrlevvpkPPD 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 486 GKWTWLLQnLIEFLSAGSLLIFV-TKKlNAEELANNLKLKEFDVLLLHGDMDQIERNKVITAFKKKEVSTLVATdVA-AR 563
Cdd:COG0514 216 DKLAQLLD-FLKEHPGGSGIVYClSRK-KVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVAT-IAfGM 292
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 571566319 564 GLDIPHIRTVLNYDVARDIDTHTHRIGRTGRAGEKGTAYTLVTEKDKE 611
Cdd:COG0514 293 GIDKPDVRFVIHYDLPKSIEAYYQEIGRAGRDGLPAEALLLYGPEDVA 340
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
279-411 |
1.60e-10 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 60.74 E-value: 1.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 279 TPIQAQAVPAALSGRDIIGI-AKTGSGKTAAFIWPMLvhimdqRELKEGDGPIgLILAPTRELSQQIYQEARKFGKVYNV 357
Cdd:cd17921 3 NPIQREALRALYLSGDSVLVsAPTSSGKTLIAELAIL------RALATSGGKA-VYIAPTRALVNQKEADLRERFGPLGK 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 571566319 358 QVCCCYGGGSKweqSKALEGGAEIVVATPgRIIDLV--KMKATNLTRVTFLVLDEA 411
Cdd:cd17921 76 NVGLLTGDPSV---NKLLLAEADILVATP-EKLDLLlrNGGERLIQDVRLVVVDEA 127
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
535-608 |
3.09e-10 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 63.60 E-value: 3.09e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 571566319 535 MDQIERNKVITAFKKKEVSTLVATDVAARGLDIPHIRTVLNYD-VA---RDIdthtHRIGRTGRAGEkGTAYTLVTEK 608
Cdd:COG1111 395 LTQKEQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLVIFYEpVPseiRSI----QRKGRTGRKRE-GRVVVLIAKG 467
|
|
| SF2_C_RecG |
cd18811 |
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a ... |
513-622 |
2.27e-09 |
|
C-terminal helicase domain of DNA helicase RecG; ATP-dependent DNA helicase RecG plays a critical role in recombination and DNA repair. RecG helps process Holliday junction intermediates to mature products by catalyzing branch migration. It is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350198 [Multi-domain] Cd Length: 159 Bit Score: 56.97 E-value: 2.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 513 NAEELANNLKLK---EFDVLLLHGDMDQIERNKVITAFKKKEVSTLVATDVAARGLDIPHIRTVLNYDVARDIDTHTHRI 589
Cdd:cd18811 46 AAVAMYEYLKERfrpELNVGLLHGRLKSDEKDAVMAEFREGEVDILVSTTVIEVGVDVPNATVMVIEDAERFGLSQLHQL 125
|
90 100 110
....*....|....*....|....*....|....
gi 571566319 590 -GRTGRAGEKGTAYTLVTEKDKEFAGHLVRNLEG 622
Cdd:cd18811 126 rGRVGRGDHQSYCLLVYKDPLTETAKQRLRVMTE 159
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
261-604 |
9.51e-09 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 59.08 E-value: 9.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 261 GFDDALIKAIRKNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLvhimdqRELKEGDGPIGLILAPTREL 340
Cdd:COG1205 40 WLPPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVL------EALLEDPGATALYLYPTKAL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 341 SQQIYQEARKFGKVY--NVQVCCCYGGGSKWEQSKALEgGAEIVVATPgriiDLVKMK--------ATNLTRVTFLVLDE 410
Cdd:COG1205 114 ARDQLRRLRELAEALglGVRVATYDGDTPPEERRWIRE-HPDIVLTNP----DMLHYGllphhtrwARFFRNLRYVVIDE 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 411 A---------------DRMfdmgfepqvRSICNHVRPDRQTLLFSATFKKRVEKLARdvLTD-PVRIVQGD---VGEana 471
Cdd:COG1205 189 AhtyrgvfgshvanvlRRL---------RRICRHYGSDPQFILASATIGNPAEHAER--LTGrPVTVVDEDgspRGE--- 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 472 dvtQHVIVFN----NNPTGKWTW-----LLQNLIEflsAG-SLLIFVTKKLNAEELANNLKlkefDVLLLHGDMDQI--- 538
Cdd:COG1205 255 ---RTFVLWNpplvDDGIRRSALaeaarLLADLVR---EGlRTLVFTRSRRGAELLARYAR----RALREPDLADRVaay 324
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 571566319 539 -------ERNKVITAFKKKEVSTLVATDVAARGLDIPHIRTVLNYDVARDIDTHTHRIGRTGRAGEKGTAYTL 604
Cdd:COG1205 325 ragylpeERREIERGLRSGELLGVVSTNALELGIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRGQDSLVVLV 397
|
|
| SF2_C_RecG_TRCF |
cd18792 |
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family ... |
513-611 |
1.41e-08 |
|
C-terminal helicase domain of the RecG family helicases; The DEAD-like helicase RecG family contains recombination factor RecG and transcription-repair coupling factor TrcF. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350179 [Multi-domain] Cd Length: 160 Bit Score: 54.58 E-value: 1.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 513 NAEELANNLKLK--EFDVLLLHGDMDQIERNKVITAFKKKEVSTLVATDVAARGLDIPHIRTVLNYDVARDIDTHTHRI- 589
Cdd:cd18792 46 SIEALAEELKELvpEARVALLHGKMTEDEKEAVMLEFREGEYDILVSTTVIEVGIDVPNANTMIIEDADRFGLSQLHQLr 125
|
90 100
....*....|....*....|..
gi 571566319 590 GRTGRAGEKGTAYTLVTEKDKE 611
Cdd:cd18792 126 GRVGRGKHQSYCYLLYPDPKKL 147
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
275-596 |
1.77e-08 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 57.80 E-value: 1.77e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 275 YTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVhimdqrelKEGdgpIGLILAPTRELSQ-QIYQEarkfgK 353
Cdd:PRK11057 23 YQQFRPGQQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPALV--------LDG---LTLVVSPLISLMKdQVDQL-----L 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 354 VYNVQVCCCYGGGSKWEQSKAL----EGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFDMG--FEPQVRSI- 426
Cdd:PRK11057 87 ANGVAAACLNSTQTREQQLEVMagcrTGQIKLLYIAPERLMMDNFLEHLAHWNPALLAVDEAHCISQWGhdFRPEYAALg 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 427 -CNHVRPDRQTLLFSATFKK--RVEKLARDVLTDPVrivqgdvgeanadvtQHVIVFNNnPTGKWTWL-----LQNLIEF 498
Cdd:PRK11057 167 qLRQRFPTLPFMALTATADDttRQDIVRLLGLNDPL---------------IQISSFDR-PNIRYTLVekfkpLDQLMRY 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 499 LSA---GSLLIFVTKKLNAEELANNLKLKEFDVLLLHGDMDQIERNKVITAFKKKEVSTLVATDVAARGLDIPHIRTVLN 575
Cdd:PRK11057 231 VQEqrgKSGIIYCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVH 310
|
330 340
....*....|....*....|.
gi 571566319 576 YDVARDIDTHTHRIGRTGRAG 596
Cdd:PRK11057 311 FDIPRNIESYYQETGRAGRDG 331
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
535-604 |
2.02e-08 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 53.90 E-value: 2.02e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 571566319 535 MDQIERNKVITAFKKKEVSTLVATDVAARGLDIPHIRTVLNYD-VARDIDThTHRIGRTGRaGEKGTAYTL 604
Cdd:cd18801 74 MSQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDLIICYDaSPSPIRM-IQRMGRTGR-KRQGRVVVL 142
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
514-608 |
3.67e-08 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 57.19 E-value: 3.67e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 514 AEELANNLKLKEFDVLLLHGD--------MDQIERNKVITAFKKKEVSTLVATDVAARGLDIPHIRTVLNYD-VARDIDT 584
Cdd:PRK13766 378 AEKIVDLLEKEGIKAVRFVGQaskdgdkgMSQKEQIEILDKFRAGEFNVLVSTSVAEEGLDIPSVDLVIFYEpVPSEIRS 457
|
90 100
....*....|....*....|....
gi 571566319 585 hTHRIGRTGRaGEKGTAYTLVTEK 608
Cdd:PRK13766 458 -IQRKGRTGR-QEEGRVVVLIAKG 479
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
299-621 |
4.25e-08 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 55.90 E-value: 4.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 299 AKTGSGKT-AAFIWpMLVHIMDQRELKegdgpigLILA-PTRELSQQIYQEARK-FGKVYNVQVCCCYGGGSKWEQSKAL 375
Cdd:cd09639 6 APTGYGKTeAALLW-ALHSLKSQKADR-------VIIAlPTRATINAMYRRAKEaFGETGLYHSSILSSRIKEMGDSEEF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 376 EG-------GAEIVVATPGRIIDLVKMKATNLTRVTF------------LVLDEADrmfdmGFEPQVRSICNHV-----R 431
Cdd:cd09639 78 EHlfplyihSNDTLFLDPITVCTIDQVLKSVFGEFGHyeftlasianslLIFDEVH-----FYDEYTLALILAVlevlkD 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 432 PDRQTLLFSATFKKRVEKLARDVLtdpvrIVQGDVGEANADVTQHVIVFNNNPTGKWTWLLQNLIEFL-SAGSLLIFVTK 510
Cdd:cd09639 153 NDVPILLMSATLPKFLKEYAEKIG-----YVEENEPLDLKPNERAPFIKIESDKVGEISSLERLLEFIkKGGSVAIIVNT 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 511 KLNAEELANNLKLK--EFDVLLLHG---DMDQIERNKVITA-FKKKEVSTLVATDVAARGLDIphirtvlNYDV----AR 580
Cdd:cd09639 228 VDRAQEFYQQLKEKgpEEEIMLIHSrftEKDRAKKEAELLLeFKKSEKFVIVATQVIEASLDI-------SVDVmiteLA 300
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 571566319 581 DIDTHTHRIGRTGRAGEKGTAYTLVTEKDKEFAGHLVRNLE 621
Cdd:cd09639 301 PIDSLIQRLGRLHRYGEKNGEEVYIITDAPDGKGQKPYPYD 341
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
486-590 |
6.60e-08 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 52.09 E-value: 6.60e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 486 GKWTWLLQNLIEFLSAGS-LLIFV--TKKLNAeeLANNLKLKEFDVLLLHGDMDQIERNKVITAFKKKEVST--LVATDV 560
Cdd:cd18793 11 GKLEALLELLEELREPGEkVLIFSqfTDTLDI--LEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRvfLLSTKA 88
|
90 100 110
....*....|....*....|....*....|....*..
gi 571566319 561 AARGLDIPHIRTVLNYDV----ARD---IDtHTHRIG 590
Cdd:cd18793 89 GGVGLNLTAANRVILYDPwwnpAVEeqaID-RAHRIG 124
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
276-411 |
1.14e-07 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 52.65 E-value: 1.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 276 TQPTPIQAQAVPAALSgRDIIGIAKTGSGKTaaFIWPMLVHIM--DQRELKEGdGPIGLILAPTRELSQQIYQEARKFGK 353
Cdd:cd18034 1 FTPRSYQLELFEAALK-RNTIVVLPTGSGKT--LIAVMLIKEMgeLNRKEKNP-KKRAVFLVPTVPLVAQQAEAIRSHTD 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 571566319 354 vYNVQVCCCYGGGSKWEQSKALE--GGAEIVVATPGRIIDL-----VKMKATNLtrvtfLVLDEA 411
Cdd:cd18034 77 -LKVGEYSGEMGVDKWTKERWKEelEKYDVLVMTAQILLDAlrhgfLSLSDINL-----LIFDEC 135
|
|
| cas3_core |
TIGR01587 |
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an ... |
299-598 |
1.24e-07 |
|
CRISPR-associated helicase Cas3; This model represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by pfam00270 (DEAD/DEAH box helicase) and pfam00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (pfam01966) that is not included within this model.
Pssm-ID: 273707 [Multi-domain] Cd Length: 359 Bit Score: 54.38 E-value: 1.24e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 299 AKTGSGKT-AAFIWpmLVHIMDQRELKEgdgpigLILA-PTRELSQQIYQEARKFGKVYNVQvcccYGGGSKWEQSKALE 376
Cdd:TIGR01587 6 APTGYGKTeAALLW--ALHSIKSQKADR------VIIAlPTRATINAMYRRAKELFGSELVG----LHHSSSFSRIKEMG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 377 GGAEIVVATPGRIIDLVKMKATNLTRVT-------------------------FLVLDEADrmfdmGFEPQVRSICNHV- 430
Cdd:TIGR01587 74 DSEEFEHLFPLYIHSNDKLFLDPITVCTidqvlksvfgefghyeftlasiansLLIFDEVH-----FYDEYTLALILAVl 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 431 ----RPDRQTLLFSATFKKRVEKLARDVltDPVRIVQGDVGEANADVTQHVIVFNNNPT-GKWTWLLQNLIEFLSAGSLL 505
Cdd:TIGR01587 149 evlkDNDVPILLMSATLPKFLKEYAEKI--GYVEFNEPLDLKEERRFENHRFILIESDKvGEISSLERLLEFIKKGGSIA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 506 IFVTKKLNAEELANNLKLK--EFDVLLLHGDMDQIERNK----VITAFKK-KEVSTLVATDVAARGLDIphirtvlNYDV 578
Cdd:TIGR01587 227 IIVNTVDRAQEFYQQLKEKapEEEIILYHSRFTEKDRAKkeaeLLREMKKsNEKFVIVATQVIEASLDI-------SADV 299
|
330 340
....*....|....*....|....
gi 571566319 579 ----ARDIDTHTHRIGRTGRAGEK 598
Cdd:TIGR01587 300 miteLAPIDSLIQRLGRLHRYGRK 323
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
492-605 |
8.40e-07 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 49.17 E-value: 8.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 492 LQNLIEFLSAGS-LLIFVTKKLNAEELAnnlklKEFDVLLLHGDMDQIERNKVITAFKKKEVSTLVATDVAARGLDIPhi 570
Cdd:cd18789 39 LEELLKRHEQGDkIIVFTDNVEALYRYA-----KRLLKPFITGETPQSEREEILQNFREGEYNTLVVSKVGDEGIDLP-- 111
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 571566319 571 rtvlNYDVARDIDTH-------THRIGRTGRAGEKGTA----YTLV 605
Cdd:cd18789 112 ----EANVAIQISGHggsrrqeAQRLGRILRPKKGGGKnaffYSLV 153
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
555-606 |
8.71e-07 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 46.93 E-value: 8.71e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 571566319 555 LVATDVAARGLDIPHIRTVLNYDVARDIDTHTHRIGRTGRAGEKGTAYTLVT 606
Cdd:cd18785 26 LVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGEVILFV 77
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
264-326 |
9.12e-07 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 52.41 E-value: 9.12e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 571566319 264 DALIKAIR---KNEYTQPTPIQAQAVPAALSGRDIIGIAKTGSGKT-AAFIWP--MLVHIMDQRELKEG 326
Cdd:COG1201 8 SLLHPAVRawfAARFGAPTPPQREAWPAIAAGESTLLIAPTGSGKTlAAFLPAldELARRPRPGELPDG 76
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
492-606 |
9.50e-07 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 48.74 E-value: 9.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 492 LQNLIEFLSAGSL-------LIFVTKKLNAEELA-----NNLKLKEFDVLLLHG----------DMDQIERNKVITAFKK 549
Cdd:cd18802 9 LQKLIEILREYFPktpdfrgIIFVERRATAVVLSrllkeHPSTLAFIRCGFLIGrgnssqrkrsLMTQRKQKETLDKFRD 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 571566319 550 KEVSTLVATDVAARGLDIPHIRTVLNYDVARDIdthTHRIGRTGRAGEKGTAYTLVT 606
Cdd:cd18802 89 GELNLLIATSVLEEGIDVPACNLVIRFDLPKTL---RSYIQSRGRARAPNSKYILMV 142
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
263-442 |
1.28e-06 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 49.34 E-value: 1.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 263 DDALIKAIRKNEYTQPTPIQAQAVPAALSG------RDIIGIAKTGSGKTAAFIWPMLVHIMDQRELkegdgpigLILAP 336
Cdd:cd17918 1 DRALIQELCKSLPFSLTKDQAQAIKDIEKDlhspepMDRLLSGDVGSGKTLVALGAALLAYKNGKQV--------AILVP 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 337 TRELSQQIYQEARKFGKVYNVQVCCcyggGSKWEQSKAlegGAEIVVATPGRIIDLVKMKAtnltrVTFLVLDEADRmfd 416
Cdd:cd17918 73 TEILAHQHYEEARKFLPFINVELVT----GGTKAQILS---GISLLVGTHALLHLDVKFKN-----LDLVIVDEQHR--- 137
|
170 180
....*....|....*....|....*.
gi 571566319 417 MGFEpQVRSICNHVRPDrqTLLFSAT 442
Cdd:cd17918 138 FGVA-QREALYNLGATH--FLEATAT 160
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
280-442 |
1.64e-06 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 48.87 E-value: 1.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 280 PIQAQAVPAAL-SGRDIIGIAKTGSGKTAAFIWPMLVHIMDqrelkegdGPIGLILAPTRELSQQIYQEarkFGKVYNVQ 358
Cdd:cd18028 4 PPQAEAVRAGLlKGENLLISIPTASGKTLIAEMAMVNTLLE--------GGKALYLVPLRALASEKYEE---FKKLEEIG 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 359 VCCCYGGGSKWEQSKALeGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADRMFDMGFEPQVRSICNHVR---PDRQ 435
Cdd:cd18028 73 LKVGISTGDYDEDDEWL-GDYDIIVATYEKFDSLLRHSPSWLRDVGVVVVDEIHLISDEERGPTLESIVARLRrlnPNTQ 151
|
....*..
gi 571566319 436 TLLFSAT 442
Cdd:cd18028 152 IIGLSAT 158
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
277-413 |
1.67e-06 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 49.35 E-value: 1.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 277 QPTPIQAQAVPAALSGRDIIGIAKTGSGKTaaFIwpmLVHIMDQRELKEGDGPIG--LILAPTREL-SQQIYQEARKFGK 353
Cdd:cd17927 2 KPRNYQLELAQPALKGKNTIICLPTGSGKT--FV---AVLICEHHLKKFPAGRKGkvVFLANKVPLvEQQKEVFRKHFER 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 571566319 354 V-YNVQVcccYGGGSKWEQSKALE-GGAEIVVATPgRII--DLVKMKATNLTRVTFLVLDEADR 413
Cdd:cd17927 77 PgYKVTG---LSGDTSENVSVEQIvESSDVIIVTP-QILvnDLKSGTIVSLSDFSLLVFDECHN 136
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
488-594 |
2.94e-06 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 47.64 E-value: 2.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 488 WTWLLQNLIEFLSAG-SLLIFVTKKLNAEELANNLKL---KEFDVLLL---HGDMDQIERNKVITAFKKKEVSTLVATDV 560
Cdd:cd18796 24 GADAYAEVIFLLERHkSTLVFTNTRSQAERLAQRLRElcpDRVPPDFIalhHGSLSRELREEVEAALKRGDLKVVVATSS 103
|
90 100 110
....*....|....*....|....*....|....
gi 571566319 561 AARGLDIPHIRTVLNYDVARDIDTHTHRIGRTGR 594
Cdd:cd18796 104 LELGIDIGDVDLVIQIGSPKSVARLLQRLGRSGH 137
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
275-464 |
3.96e-06 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 48.30 E-value: 3.96e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 275 YTQPTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVhimdqrelkegDGPIGLILAPTRELSQ-QIYQEARKfgk 353
Cdd:cd17920 10 YDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLPALL-----------LDGVTLVVSPLISLMQdQVDRLQQL--- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 354 vyNVQVCCCYGGGSKWEQSKALE----GGAEIVVATP-----GRIIDLVKmKATNLTRVTFLVLDEA--------Drmfd 416
Cdd:cd17920 76 --GIRAAALNSTLSPEEKREVLLriknGQYKLLYVTPerllsPDFLELLQ-RLPERKRLALIVVDEAhcvsqwghD---- 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 571566319 417 mgFEPQVRSICNHVR--PDRQTLLFSATFKKRVEklaRDV-----LTDPVRIVQG 464
Cdd:cd17920 149 --FRPDYLRLGRLRRalPGVPILALTATATPEVR---EDIlkrlgLRNPVIFRAS 198
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
282-442 |
9.65e-06 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 46.81 E-value: 9.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 282 QAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMDQRELKEgdgpigLILAPTRELSQQIYQEARKFGKVYNVQV-C 360
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALLRDPGSRA------LYLYPTKALAQDQLRSLRELLEQLGLGIrV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 361 CCYGGGSKWEQSKAL-EGGAEIVVATPgriidlvKM-----------KATNLTRVTFLVLDEAdRMFDMGFEPQV----- 423
Cdd:cd17923 79 ATYDGDTPREERRAIiRNPPRILLTNP-------DMlhyallphhdrWARFLRNLRYVVLDEA-HTYRGVFGSHValllr 150
|
170 180
....*....|....*....|.
gi 571566319 424 --RSICNHVRPDRQTLLFSAT 442
Cdd:cd17923 151 rlRRLCRRYGADPQFILTSAT 171
|
|
| SF2_C_TRCF |
cd18810 |
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair ... |
528-621 |
1.27e-05 |
|
C-terminal helicase domain of the transcription-repair coupling factor; Transcription-repair coupling factor (TrcF) dissociates transcription elongation complexes blocked at nonpairing lesions and mediates recruitment of DNA repair proteins. TrcF is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350197 [Multi-domain] Cd Length: 151 Bit Score: 45.80 E-value: 1.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 528 VLLLHGDMDQIERNKVITAFKKKEVSTLVATDVAARGLDIPHIRTVL--NYDVARDIDTHTHRiGRTGRAGEKGTAYTLV 605
Cdd:cd18810 54 IAIAHGQMTENELEEVMLEFAKGEYDILVCTTIIESGIDIPNANTIIieRADKFGLAQLYQLR-GRVGRSKERAYAYFLY 132
|
90
....*....|....*.
gi 571566319 606 tEKDKEFAGHLVRNLE 621
Cdd:cd18810 133 -PDQKKLTEDALKRLE 147
|
|
| RecG |
COG1200 |
RecG-like helicase [Replication, recombination and repair]; |
513-560 |
1.28e-05 |
|
RecG-like helicase [Replication, recombination and repair];
Pssm-ID: 440813 [Multi-domain] Cd Length: 684 Bit Score: 48.89 E-value: 1.28e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 571566319 513 NAEELANNLK--LKEFDVLLLHGDMDQIERNKVITAFKKKEVSTLVATDV 560
Cdd:COG1200 489 AAEETYEELReaFPGLRVGLLHGRMKPAEKDAVMAAFKAGEIDVLVATTV 538
|
|
| SF2_C_UvrB |
cd18790 |
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) ... |
503-573 |
1.31e-05 |
|
C-terminal helicase domain of the UvrB family helicases; Excinuclease ABC subunit B (or UvrB) plays a central role in nucleotide excision repair (NER). Together with other components of the NER system, like UvrA, UvrC, UvrD (helicase II), and DNA polymerase I, it recognizes and cleaves damaged DNA in a multistep ATP-dependent reaction. UvrB is critical for the second phase of damage recognition by verifying the nature of the damage and forming the pre-incision complex. Its ATPase site becomes activated in the presence of UvrA and damaged DNA. Its activity is strand destabilization via distortion of the DNA at lesion site, with very limited DNA unwinding. UvrB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350177 [Multi-domain] Cd Length: 171 Bit Score: 46.08 E-value: 1.31e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 571566319 503 SLLIFVTKKLnAEELANNLKLKEFDVLLLHGDMDQIERNKVITAFKKKEVSTLVATDVAARGLDIPHIRTV 573
Cdd:cd18790 30 VLVTTLTKRM-AEDLTEYLQELGVKVRYLHSEIDTLERVEIIRDLRLGEFDVLVGINLLREGLDLPEVSLV 99
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
502-597 |
2.10e-05 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 44.89 E-value: 2.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 502 GSLLIFVTKKLNAEELANNLKLKEFDVLLLHGDMDQIERNKVITAFKKKEVSTLVATdVA-ARGLDIPHIRTVLNYDVAR 580
Cdd:cd18794 31 GSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVAT-VAfGMGIDKPDVRFVIHYSLPK 109
|
90
....*....|....*..
gi 571566319 581 DIDTHTHRIGRTGRAGE 597
Cdd:cd18794 110 SMESYYQESGRAGRDGL 126
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
482-592 |
2.12e-05 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 47.91 E-value: 2.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 482 NNPTGKWTWLLQNLIEFLSAG-SLLIFVTKKLNAEELANNLKLKEFDVLLLHGDMDQIERNKVITAFKKKEVST--LVAT 558
Cdd:COG0553 529 SGRSAKLEALLELLEELLAEGeKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPvfLISL 608
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 571566319 559 DVAARGLDIPHIRTVLNYD-----------VARdidthTHRIGRT 592
Cdd:COG0553 609 KAGGEGLNLTAADHVIHYDlwwnpaveeqaIDR-----AHRIGQT 648
|
|
| PRK10917 |
PRK10917 |
ATP-dependent DNA helicase RecG; Provisional |
512-568 |
4.54e-05 |
|
ATP-dependent DNA helicase RecG; Provisional
Pssm-ID: 236794 [Multi-domain] Cd Length: 681 Bit Score: 47.07 E-value: 4.54e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 571566319 512 LNAEELANNLK--LKEFDVLLLHGDMDQIERNKVITAFKKKEVSTLVATDVAARGLDIP 568
Cdd:PRK10917 490 QSAEETYEELQeaFPELRVGLLHGRMKPAEKDAVMAAFKAGEIDILVATTVIEVGVDVP 548
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
280-598 |
6.48e-05 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 46.81 E-value: 6.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 280 PIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHimdqrelkegdGPIGLILAPTRELSQ-QIYQearkfgkVYNVQ 358
Cdd:PLN03137 463 PNQREIINATMSGYDVFVLMPTGGGKSLTYQLPALIC-----------PGITLVISPLVSLIQdQIMN-------LLQAN 524
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 359 VCCCY-GGGSKW-EQSKAL-EGGAE-----IVVATPGRII--DLVKMKATNLTRVTFL---VLDEADRMFDMGFEpqvrs 425
Cdd:PLN03137 525 IPAASlSAGMEWaEQLEILqELSSEyskykLLYVTPEKVAksDSLLRHLENLNSRGLLarfVIDEAHCVSQWGHD----- 599
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 426 icnhVRPDRQTLlfsATFKKRVEKLARDVLTDPVRI-VQGDVGEANADVtqHVIVFN---NNPT------GKWTWLLQNL 495
Cdd:PLN03137 600 ----FRPDYQGL---GILKQKFPNIPVLALTATATAsVKEDVVQALGLV--NCVVFRqsfNRPNlwysvvPKTKKCLEDI 670
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 496 IEFLSAGSL----LIFVTKKLNAEELANnlKLKEF--DVLLLHGDMDQIERNKVITAFKKKEVSTLVATDVAARGLDIPH 569
Cdd:PLN03137 671 DKFIKENHFdecgIIYCLSRMDCEKVAE--RLQEFghKAAFYHGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPD 748
|
330 340
....*....|....*....|....*....
gi 571566319 570 IRTVLNYDVARDIDTHTHRIGRTGRAGEK 598
Cdd:PLN03137 749 VRFVIHHSLPKSIEGYHQECGRAGRDGQR 777
|
|
| DEXHc_RLR |
cd18036 |
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ... |
278-410 |
7.12e-05 |
|
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350794 [Multi-domain] Cd Length: 204 Bit Score: 44.77 E-value: 7.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 278 PTPIQAQAVPAALSGRDIIGIAKTGSGKTAAFIWPMLVHIMDQRelKEGDGPIGLILAPTREL-SQQIYQEARKFGKVYN 356
Cdd:cd18036 3 LRNYQLELVLPALRGKNTIICAPTGSGKTRVAVYICRHHLEKRR--SAGEKGRVVVLVNKVPLvEQQLEKFFKYFRKGYK 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 571566319 357 VQvcccygGGSKWEQSKalEGGAEIVVA------TPGRIIDLVKMKATN----LTRVTFLVLDE 410
Cdd:cd18036 81 VT------GLSGDSSHK--VSFGQIVKAsdviicTPQILINNLLSGREEervyLSDFSLLIFDE 136
|
|
| PRK10689 |
PRK10689 |
transcription-repair coupling factor; Provisional |
277-604 |
2.41e-04 |
|
transcription-repair coupling factor; Provisional
Pssm-ID: 182649 [Multi-domain] Cd Length: 1147 Bit Score: 44.74 E-value: 2.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 277 QPTPIQAQAVPAALS------GRDIIGIAKTGSGKTAAFIWPMLVHIMDQRELKegdgpiglILAPTRELSQQIYQEARK 350
Cdd:PRK10689 600 ETTPDQAQAINAVLSdmcqplAMDRLVCGDVGFGKTEVAMRAAFLAVENHKQVA--------VLVPTTLLAQQHYDNFRD 671
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 351 FGKVYNVQVCCCYGGGSKWEQSKALEGGAE----IVVATPGRIIDLVKMKATNLtrvtfLVLDEADRmFDMGFEPQVRSI 426
Cdd:PRK10689 672 RFANWPVRIEMLSRFRSAKEQTQILAEAAEgkidILIGTHKLLQSDVKWKDLGL-----LIVDEEHR-FGVRHKERIKAM 745
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 427 cnhvRPDRQTLLFSATFKKRVEKLA----RD---VLTDPVR--IVQGDVGEANADVTQHVIvfnnnptgkwtwllqnLIE 497
Cdd:PRK10689 746 ----RADVDILTLTATPIPRTLNMAmsgmRDlsiIATPPARrlAVKTFVREYDSLVVREAI----------------LRE 805
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 498 FLSAGSLLIFVTKKLNAEELANNLK--LKEFDVLLLHGDMDQIERNKVITAFKKKEVSTLVATDVAARGLDIPHIRTVL- 574
Cdd:PRK10689 806 ILRGGQVYYLYNDVENIQKAAERLAelVPEARIAIGHGQMRERELERVMNDFHHQRFNVLVCTTIIETGIDIPTANTIIi 885
|
330 340 350
....*....|....*....|....*....|....
gi 571566319 575 ----NYDVARdidTHTHRiGRTGRAGEKGTAYTL 604
Cdd:PRK10689 886 eradHFGLAQ---LHQLR-GRVGRSHHQAYAWLL 915
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
281-386 |
5.90e-04 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 41.96 E-value: 5.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 281 IQAQAVPAAL-SGRDIIGIAKTGSGKTAAFIWPMLVHIMDQRELKEGDgPIGLILAPTRELSQQIYQEAR-KFGKvynVQ 358
Cdd:cd18023 5 IQSEVFPDLLySDKNFVVSAPTGSGKTVLFELAILRLLKERNPLPWGN-RKVVYIAPIKALCSEKYDDWKeKFGP---LG 80
|
90 100 110
....*....|....*....|....*....|...
gi 571566319 359 VCCC-----YGGGSKWEQSKaleggAEIVVATP 386
Cdd:cd18023 81 LSCAeltgdTEMDDTFEIQD-----ADIILTTP 108
|
|
| DEXHc_Hef |
cd18035 |
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ... |
277-413 |
8.43e-04 |
|
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350793 [Multi-domain] Cd Length: 181 Bit Score: 40.96 E-value: 8.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 277 QPTPIQAQAVPAALSGRDIIgIAKTGSGKTAAFIWpmlvhIMDQReLKEGDGPIgLILAPTRELsqqIYQEARKFGKVYN 356
Cdd:cd18035 2 ERRLYQVLIAAVALNGNTLI-VLPTGLGKTIIAIL-----VAADR-LTKKGGKV-LILAPSRPL---VEQHAENLKRVLN 70
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 571566319 357 VQ-VCCCYGGGSKWEQSKALEGGAEIVVATPGRIIDLVKMKATNLTRVTFLVLDEADR 413
Cdd:cd18035 71 IPdKITSLTGEVKPEERAERWDASKIIVATPQVIENDLLAGRITLDDVSLLIFDEAHH 128
|
|
| secA |
PRK12898 |
preprotein translocase subunit SecA; Reviewed |
556-645 |
1.18e-03 |
|
preprotein translocase subunit SecA; Reviewed
Pssm-ID: 237253 [Multi-domain] Cd Length: 656 Bit Score: 42.30 E-value: 1.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 556 VATDVAARGLDIPhirtvLNYDVARD-----IDTHTHR--------IGRTGRAGEKGTAYTLVTEKD---KEFAGHLVRN 619
Cdd:PRK12898 526 VATNMAGRGTDIK-----LEPGVAARgglhvILTERHDsaridrqlAGRCGRQGDPGSYEAILSLEDdllQSFLGSRGLA 600
|
90 100
....*....|....*....|....*.
gi 571566319 620 LEGANQEVPKSLMDLAMQSAWFRKSR 645
Cdd:PRK12898 601 IRRMELLGPRGGRALGALLLRRAQRR 626
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
301-444 |
2.68e-03 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 39.19 E-value: 2.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571566319 301 TGSGKT---AAFIWpmlvhimdqRELKEGDGPIGLILAPTRELSQQIYQEARKFGKVYnVQVCCCYGGGSKweqsKALEG 377
Cdd:pfam04851 32 TGSGKTltaAKLIA---------RLFKKGPIKKVLFLVPRKDLLEQALEEFKKFLPNY-VEIGEIISGDKK----DESVD 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 571566319 378 GAEIVVATP---GRIIDLVKMKATNLTRVTFLVlDEADRmfdmGFEPQVRSICNHVRPdrQTLL-FSATFK 444
Cdd:pfam04851 98 DNKIVVTTIqslYKALELASLELLPDFFDVIII-DEAHR----SGASSYRNILEYFKP--AFLLgLTATPE 161
|
|
| VirD4 |
COG3505 |
Type IV secretory pathway, VirD4 component, TraG/TraD family ATPase [Intracellular trafficking, ... |
298-355 |
4.26e-03 |
|
Type IV secretory pathway, VirD4 component, TraG/TraD family ATPase [Intracellular trafficking, secretion, and vesicular transport];
Pssm-ID: 442728 [Multi-domain] Cd Length: 402 Bit Score: 40.35 E-value: 4.26e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 571566319 298 IAKTGSGKTAAFIWPMLvhimdqRELKEGDGpiGLILAPTRELSQQIYQEARKFG-KVY 355
Cdd:COG3505 5 IGPTGSGKTVGLVIPNL------TQLARGES--VVVTDPKGDLAELTAGFRRRAGyDVY 55
|
|
| SF2_C_EcoAI-like |
cd18799 |
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family ... |
505-574 |
5.53e-03 |
|
C-terminal helicase domain of EcoAI HsdR-like restriction enzyme family helicases; This family is composed of helicase restriction enzymes, including the HsdR subunit of restriction-modification enzymes such as Escherichia coli type I restriction enzyme EcoAI R protein (R.EcoAI). The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. The HsdR or R subunit is required for both nuclease and ATPase activities, but not for modification. These proteins are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350186 [Multi-domain] Cd Length: 116 Bit Score: 37.54 E-value: 5.53e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 571566319 505 LIFVTKKLNAEELANNLKLKEFDVLLLHGD--MDQIERNKVITAFK-KKEVSTLVATDVAARGLDIPHIRTVL 574
Cdd:cd18799 10 LIFCVSIEHAEFMAEAFNEAGIDAVALNSDysDRERGDEALILLFFgELKPPILVTVDLLTTGVDIPEVDNVV 82
|
|
| |
