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Conserved domains on  [gi|568947207|ref|XP_006540631|]
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ankyrin repeat and SOCS box protein 7 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
21-192 2.01e-32

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.06  E-value: 2.01e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  21 GGFTALHYAAMHGRARIARLMLEseyRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAII 100
Cdd:COG0666   86 GGNTLLHAAARNGDLEIVKLLLE---AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207 101 RERSSCVKILLDHNANIDIQNGF---LLRYAVIKSNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCARMLYNY 177
Cdd:COG0666  163 NGNLEIVKLLLEAGADVNARDNDgetPLHLAAENGHLEIVKLLLEAGADVNA-KDNDGKTALDLAAENGNLEIVKLLLEA 241

                        170
                 ....*....|....*
gi 568947207 178 GADTNTRNYEGQTPL 192
Cdd:COG0666  242 GADLNAKDKDGLTAL 256
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 214-258 4.73e-25

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239696  Cd Length: 45  Bit Score: 93.76  E-value: 4.73e-25
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 568947207 214 RQPRTLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHKFDD 258
Cdd:cd03726    1 RQPRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKHKFDD 45
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
21-192 2.01e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.06  E-value: 2.01e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  21 GGFTALHYAAMHGRARIARLMLEseyRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAII 100
Cdd:COG0666   86 GGNTLLHAAARNGDLEIVKLLLE---AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207 101 RERSSCVKILLDHNANIDIQNGF---LLRYAVIKSNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCARMLYNY 177
Cdd:COG0666  163 NGNLEIVKLLLEAGADVNARDNDgetPLHLAAENGHLEIVKLLLEAGADVNA-KDNDGKTALDLAAENGNLEIVKLLLEA 241

                        170
                 ....*....|....*
gi 568947207 178 GADTNTRNYEGQTPL 192
Cdd:COG0666  242 GADLNAKDKDGLTAL 256
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 214-258 4.73e-25

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 93.76  E-value: 4.73e-25
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 568947207 214 RQPRTLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHKFDD 258
Cdd:cd03726    1 RQPRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKHKFDD 45
Ank_2 pfam12796
Ankyrin repeats (3 copies);
26-121 1.15e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 83.63  E-value: 1.15e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207   26 LHYAAMHGRARIARLMLESEYRsdiINAKSNDGWTPLHVAAHYGRDSFVRLLLEfKAEVDpLSDKGTTPLQLAIIRERSS 105
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAD---ANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVN-LKDNGRTALHYAARSGHLE 75

                          90
                  ....*....|....*.
gi 568947207  106 CVKILLDHNANIDIQN 121
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 35-196 1.60e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 81.46  E-value: 1.60e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  35 ARIARLMLEseYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHN 114
Cdd:PHA02878 147 AEITKLLLS--YGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENG 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207 115 ANIDIQN-----------GFLLRYAVIKsnhsycrMFLQRGADTNLGRLEDGQTPLHLSALRDDVLcaRMLYNYGADTNT 183
Cdd:PHA02878 225 ASTDARDkcgntplhisvGYCKDYDILK-------LLLEHGVDVNAKSYILGLTALHSSIKSERKL--KLLLEYGADINS 295

                        170
                 ....*....|...
gi 568947207 184 RNYEGQTPLAVSI 196
Cdd:PHA02878 296 LNSYKLTPLSSAV 308
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 215-253 7.82e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 52.94  E-value: 7.82e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568947207  215 QPRTLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLK 253
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 217-255 1.40e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 43.94  E-value: 1.40e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 568947207   217 RTLQDLCRIKIRQCIGlqnlkLLDELPIAKVMKDYLKHK 255
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 22-163 4.51e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 47.31  E-value: 4.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  22 GFTALHYAAMHGRARIARLMLEsEYRSDIINAKSND---GWTPLHVAAHYGRDSFVRLLLEFKAEV-------------- 84
Cdd:cd22192   51 GETALHVAALYDNLEAAVVLME-AAPELVNEPMTSDlyqGETALHIAVVNQNLNLVRELIARGADVvspratgtffrpgp 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  85 DPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF---LLRYAVIKSNHSY-CRMF---LQRGADTNLGRLE---- 153
Cdd:cd22192  130 KNLIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLgntVLHILVLQPNKTFaCQMYdliLSYDKEDDLQPLDlvpn 209

                        170
                 ....*....|.
gi 568947207 154 -DGQTPLHLSA 163
Cdd:cd22192  210 nQGLTPFKLAA 220
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 57-85 2.75e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 2.75e-04
                           10        20
                   ....*....|....*....|....*....
gi 568947207    57 DGWTPLHVAAHYGRDSFVRLLLEFKAEVD 85
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
21-192 2.01e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.06  E-value: 2.01e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  21 GGFTALHYAAMHGRARIARLMLEseyRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAII 100
Cdd:COG0666   86 GGNTLLHAAARNGDLEIVKLLLE---AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207 101 RERSSCVKILLDHNANIDIQNGF---LLRYAVIKSNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCARMLYNY 177
Cdd:COG0666  163 NGNLEIVKLLLEAGADVNARDNDgetPLHLAAENGHLEIVKLLLEAGADVNA-KDNDGKTALDLAAENGNLEIVKLLLEA 241

                        170
                 ....*....|....*
gi 568947207 178 GADTNTRNYEGQTPL 192
Cdd:COG0666  242 GADLNAKDKDGLTAL 256
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-192 1.25e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 115.44  E-value: 1.25e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  13 DPTVKDLIGGFTALHYAAMHGRARIARLMLEseyRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGT 92
Cdd:COG0666   45 LALALADALGALLLLAAALAGDLLVALLLLA---AGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGE 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  93 TPLQLAIIRERSSCVKILLDHNANIDIQNGF---LLRYAVIKSNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVL 169
Cdd:COG0666  122 TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDgntPLHLAAANGNLEIVKLLLEAGADVNA-RDNDGETPLHLAAENGHLE 200

                        170       180
                 ....*....|....*....|...
gi 568947207 170 CARMLYNYGADTNTRNYEGQTPL 192
Cdd:COG0666  201 IVKLLLEAGADVNAKDNDGKTAL 223
SOCS_ASB7 cd03726
SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a ...
 214-258 4.73e-25

SOCS (suppressors of cytokine signaling) box of ASB7-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239696  Cd Length: 45  Bit Score: 93.76  E-value: 4.73e-25
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 568947207 214 RQPRTLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHKFDD 258
Cdd:cd03726    1 RQPRTLQDLCRIKIRHCIGLQNLKLLDELPIAKVMKDYLKHKFDD 45
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
17-192 5.13e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 92.32  E-value: 5.13e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  17 KDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQ 96
Cdd:COG0666   13 AALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLH 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  97 LAIIRERSSCVKILLDHNANIDIQNGF---LLRYAVIKSNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCARM 173
Cdd:COG0666   93 AAARNGDLEIVKLLLEAGADVNARDKDgetPLHLAAYNGNLEIVKLLLEAGADVNA-QDNDGNTPLHLAAANGNLEIVKL 171

                        170
                 ....*....|....*....
gi 568947207 174 LYNYGADTNTRNYEGQTPL 192
Cdd:COG0666  172 LLEAGADVNARDNDGETPL 190
Ank_2 pfam12796
Ankyrin repeats (3 copies);
26-121 1.15e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 83.63  E-value: 1.15e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207   26 LHYAAMHGRARIARLMLESEYRsdiINAKSNDGWTPLHVAAHYGRDSFVRLLLEfKAEVDpLSDKGTTPLQLAIIRERSS 105
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGAD---ANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVN-LKDNGRTALHYAARSGHLE 75

                          90
                  ....*....|....*.
gi 568947207  106 CVKILLDHNANIDIQN 121
Cdd:pfam12796  76 IVKLLLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 35-196 1.60e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 81.46  E-value: 1.60e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  35 ARIARLMLEseYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHN 114
Cdd:PHA02878 147 AEITKLLLS--YGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENG 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207 115 ANIDIQN-----------GFLLRYAVIKsnhsycrMFLQRGADTNLGRLEDGQTPLHLSALRDDVLcaRMLYNYGADTNT 183
Cdd:PHA02878 225 ASTDARDkcgntplhisvGYCKDYDILK-------LLLEHGVDVNAKSYILGLTALHSSIKSERKL--KLLLEYGADINS 295

                        170
                 ....*....|...
gi 568947207 184 RNYEGQTPLAVSI 196
Cdd:PHA02878 296 LNSYKLTPLSSAV 308
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 26-182 1.34e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 75.41  E-value: 1.34e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  26 LHYAAMHGRARIARLMLES-EYRSDIInakSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERS 104
Cdd:PHA02875  72 LHDAVEEGDVKAVEELLDLgKFADDVF---YKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207 105 SCVKILLDHNANIDIQNGF---LLRYAVIKSNHSYCRMFLQRGADTN-LGRleDGQTPLHLSALRDDVL-CARMLYNYGA 179
Cdd:PHA02875 149 KGIELLIDHKACLDIEDCCgctPLIIAMAKGDIAICKMLLDSGANIDyFGK--NGCVAALCYAIENNKIdIVRLFIKRGA 226


                 ...
gi 568947207 180 DTN 182
Cdd:PHA02875 227 DCN 229
Ank_2 pfam12796
Ankyrin repeats (3 copies);
62-185 4.78e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.60  E-value: 4.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207   62 LHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHnANIDIQNgfllryaviksnhsycrmfl 141
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-------------------- 59

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 568947207  142 qrgadtnlgrleDGQTPLHLSALRDDVLCARMLYNYGADTNTRN 185
Cdd:pfam12796  60 ------------NGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 215-255 1.26e-13

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 63.26  E-value: 1.26e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568947207 215 QPRTLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHK 255
Cdd:cd03587    1 NPRSLQHLCRLAIRRCLGKRRLDLIDKLPLPPRLKDYLLYK 41
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 214-255 1.50e-13

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 63.28  E-value: 1.50e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 568947207 214 RQPRTLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHK 255
Cdd:cd03716    1 STPRSLQHLCRLAIRRCLGRRRLELIKKLPLPPRLKDYLLYE 42
Ank_2 pfam12796
Ankyrin repeats (3 copies);
4-85 1.07e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.44  E-value: 1.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207    4 VPQLSERPSDPTVKDLIGgFTALHYAAMHGRARIARLMLESEyrsdIINAKsNDGWTPLHVAAHYGRDSFVRLLLEFKAE 83
Cdd:pfam12796  13 VKLLLENGADANLQDKNG-RTALHLAAKNGHLEIVKLLLEHA----DVNLK-DNGRTALHYAARSGHLEIVKLLLEKGAD 86


                  ..
gi 568947207   84 VD 85
Cdd:pfam12796  87 IN 88
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 22-149 1.16e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 66.94  E-value: 1.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  22 GFTALHYAAMHGRARIARLMLESEYRSDIinaKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIR 101
Cdd:PHA02875 102 GMTPLHLATILKKLDIMKLLIARGADPDI---PNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAK 178

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568947207 102 ERSSCVKILLDHNANIDI--QNG--FLLRYAVIKSNHSYCRMFLQRGADTNL 149
Cdd:PHA02875 179 GDIAICKMLLDSGANIDYfgKNGcvAALCYAIENNKIDIVRLFIKRGADCNI 230
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-121 1.35e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 66.13  E-value: 1.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207   4 VPQLSERPSDPTVKDlIGGFTALHYAAMHGRARIARLMLEseyRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAE 83
Cdd:COG0666  169 VKLLLEAGADVNARD-NDGETPLHLAAENGHLEIVKLLLE---AGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGAD 244

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568947207  84 VDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN 121
Cdd:COG0666  245 LNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 26-256 2.66e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 65.84  E-value: 2.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  26 LHYAAMHGRARIARLMLESEYRsdiINAKSNDGWTPLHVAAHY----GRD-SFVRLLLEFKAEVDPLSDKGTTPLQLAII 100
Cdd:PHA03100  39 LYLAKEARNIDVVKILLDNGAD---INSSTKNNSTPLHYLSNIkynlTDVkEIVKLLLEYGANVNAPDNNGITPLLYAIS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207 101 RER--SSCVKILLDHNANIDIQN--GFLLRYAVIKSNH---SYCRMFLQRGADTN----------LGRLED-----GQTP 158
Cdd:PHA03100 116 KKSnsYSIVEYLLDNGANVNIKNsdGENLLHLYLESNKidlKILKLLIDKGVDINaknrvnyllsYGVPINikdvyGFTP 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207 159 LHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSIsisgssRPC-LDFLQDVTRQPRTLQDlcrikIRQCIGLQNLK 237
Cdd:PHA03100 196 LHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAI------LNNnKEIFKLLLNNGPSIKT-----IIETLLYFKDK 264

                        250
                 ....*....|....*....
gi 568947207 238 LLDELPIAKVMKDYLKHKF 256
Cdd:PHA03100 265 DLNTITKIKMLKKSIMYMF 283
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 4-200 6.40e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 65.08  E-value: 6.40e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207   4 VPQLSERPSDPTVKDlIGGFTALHYAAMHG--RARIARLMLeseyRSDIINAKSNDGWTPLHVAAHYGRDS-FVRLLLEF 80
Cdd:PHA02876 290 VPKLLERGADVNAKN-IKGETPLYLMAKNGydTENIRTLIM----LGADVNAADRLYITPLHQASTLDRNKdIVITLLEL 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  81 KAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQN---GFLLRYAVIKSN-HSYCRMFLQRGADTNlGRLEDGQ 156
Cdd:PHA02876 365 GANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSqkiGTALHFALCGTNpYMSVKTLIDRGANVN-SKNKDLS 443

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 568947207 157 TPLHLSALRD---DVLcaRMLYNYGADTNTRNYEGQTPLAVSISISG 200
Cdd:PHA02876 444 TPLHYACKKNcklDVI--EMLLDNGADVNAINIQNQYPLLIALEYHG 488
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 25-197 1.06e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 61.16  E-value: 1.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  25 ALHYAAMHGRARIARLMLESEYRSdiiNAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERS 104
Cdd:PHA02875   5 ALCDAILFGELDIARRLLDIGINP---NFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207 105 SCVKILLDHNANID---IQNGFL-LRYAVIKSNHSYCRMFLQRGADTNLGRlEDGQTPLHLSALRDDVLCARMLYNYGAD 180
Cdd:PHA02875  82 KAVEELLDLGKFADdvfYKDGMTpLHLATILKKLDIMKLLIARGADPDIPN-TDKFSPLHLAVMMGDIKGIELLIDHKAC 160

                        170
                 ....*....|....*..
gi 568947207 181 TNTRNYEGQTPLAVSIS 197
Cdd:PHA02875 161 LDIEDCCGCTPLIIAMA 177
PHA03095 PHA03095
ankyrin-like protein; Provisional
 22-192 3.44e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 59.65  E-value: 3.44e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  22 GFTALHYAAMHG-RARIARLMLEseYRSDIiNAKSNDGWTPLHV-----AAHYGrdsFVRLLLEFKAEVDPLSDKGTTPL 95
Cdd:PHA03095  83 GFTPLHLYLYNAtTLDVIKLLIK--AGADV-NAKDKVGRTPLHVylsgfNINPK---VIRLLLRKGADVNALDLYGMTPL 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  96 QLAIIRERSS--CVKILLDHNANI----DIQNGFLLRYAV-IKSNHSYCRMFLQRGADTNlGRLEDGQTPLHLSALRDDv 168
Cdd:PHA03095 157 AVLLKSRNANveLLRLLIDAGADVyavdDRFRSLLHHHLQsFKPRARIVRELIRAGCDPA-ATDMLGNTPLHSMATGSS- 234

                        170       180
                 ....*....|....*....|....*...
gi 568947207 169 lCARML-YNY---GADTNTRNYEGQTPL 192
Cdd:PHA03095 235 -CKRSLvLPLliaGISINARNRYGQTPL 261
PHA03095 PHA03095
ankyrin-like protein; Provisional
 7-118 5.07e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 59.27  E-value: 5.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207   7 LSERPSDPTVKDLIGGfTALHYAAMHGRARiarlmleseyRSDI---------INAKSNDGWTPLHVAAHYGRDSFVRLL 77
Cdd:PHA03095 208 LIRAGCDPAATDMLGN-TPLHSMATGSSCK----------RSLVlplliagisINARNRYGQTPLHYAAVFNNPRACRRL 276

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568947207  78 LEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANID 118
Cdd:PHA03095 277 IALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAE 317
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 36-192 7.42e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 58.92  E-value: 7.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  36 RIARLMLEseyRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNA 115
Cdd:PHA02876 159 LIAEMLLE---GGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRS 235

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207 116 NIDiQNGFLLRYAVIKSNHSYCRMFLQRGADTNlgRLEDGQ-TPLHLSALRDDV--LCARMLyNYGADTNTRNYEGQTPL 192
Cdd:PHA02876 236 NIN-KNDLSLLKAIRNEDLETSLLLYDAGFSVN--SIDDCKnTPLHHASQAPSLsrLVPKLL-ERGADVNAKNIKGETPL 311
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 215-253 7.82e-10

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 52.94  E-value: 7.82e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568947207  215 QPRTLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLK 253
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAIDKLPLPPLLKDYLL 39
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 4-196 2.43e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 57.28  E-value: 2.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207   4 VPQLSERPSDPTVKDlIGGFTALHYAAMHGRARIARLMLEseyRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAE 83
Cdd:PHA02874 140 IKMLFEYGADVNIED-DNGCYPIHIAIKHNFFDIIKLLLE---KGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNH 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  84 VDPLSDKGTTPLQLAIIRERSscVKILLDHNANIDIQNgfllryaviksnhsycrmflqrgadtnlgrlEDGQTPLH--L 161
Cdd:PHA02874 216 IMNKCKNGFTPLHNAIIHNRS--AIELLINNASINDQD-------------------------------IDGSTPLHhaI 262

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 568947207 162 SALRDDVLCARMLYNyGADTNTRNYEGQTPLAVSI 196
Cdd:PHA02874 263 NPPCDIDIIDILLYH-KADISIKDNKGENPIDTAF 296
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 13-113 4.61e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 56.45  E-value: 4.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  13 DPTVKDLIGgfTALHYAAMHGRARIARLMLESEYRSdiiNAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGT 92
Cdd:PTZ00322  75 DPVVAHMLT--VELCQLAASGDAVGARILLTGGADP---NCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGK 149

                         90       100
                 ....*....|....*....|.
gi 568947207  93 TPLQLAIIRERSSCVKILLDH 113
Cdd:PTZ00322 150 TPLELAEENGFREVVQLLSRH 170
Ank_4 pfam13637
Ankyrin repeats (many copies);
58-111 5.94e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.12  E-value: 5.94e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568947207   58 GWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILL 111
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 27-197 2.08e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 54.49  E-value: 2.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  27 HYAAMHGrARIARLMLESEYRSDIINAKSNdgwtpLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSC 106
Cdd:PLN03192 500 HHKELHD-LNVGDLLGDNGGEHDDPNMASN-----LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDC 573

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207 107 VKILLDHNANI---DIQNGFLLRYAVIKSNHSYCRMFLQrgadtnLGRLEDGQTP---LHLSALRDDVLCARMLYNYGAD 180
Cdd:PLN03192 574 VLVLLKHACNVhirDANGNTALWNAISAKHHKIFRILYH------FASISDPHAAgdlLCTAAKRNDLTAMKELLKQGLN 647

                        170
                 ....*....|....*..
gi 568947207 181 TNTRNYEGQTPLAVSIS 197
Cdd:PLN03192 648 VDSEDHQGATALQVAMA 664
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 215-253 4.29e-08

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 48.36  E-value: 4.29e-08
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 568947207 215 QPRTLQDLCRIKIRQCIGLQNlklLDELPIAKVMKDYLK 253
Cdd:cd03717    2 SVRSLQHLCRFVIRQCTRRDL---IDQLPLPRRLKDYLK 37
PHA03095 PHA03095
ankyrin-like protein; Provisional
 12-173 1.94e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.56  E-value: 1.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  12 SDPTVKDLIGgFTALHYAAMHGRARiARLMLESEYRSDIINAKSNDGWTPLHVAAHYG--RDSFVRLLLEFKAEVDPLSD 89
Cdd:PHA03095 178 ADVYAVDDRF-RSLLHHHLQSFKPR-ARIVRELIRAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGISINARNR 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  90 KGTTPLQlaiirersscvkilldhnanidiqngfllrYAVIKSNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVL 169
Cdd:PHA03095 256 YGQTPLH------------------------------YAAVFNNPRACRRLIALGADINA-VSSDGNTPLSLMVRNNNGR 304


                 ....
gi 568947207 170 CARM 173
Cdd:PHA03095 305 AVRA 308
Ank_4 pfam13637
Ankyrin repeats (many copies);
24-78 2.29e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.50  E-value: 2.29e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568947207   24 TALHYAAMHGRARIARLMLESEYRsdiINAKSNDGWTPLHVAAHYGRDSFVRLLL 78
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGAD---INAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 41-196 7.30e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.58  E-value: 7.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  41 MLESEYRSDIINAKSNdgwTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQ 120
Cdd:PHA02874 110 ILDCGIDVNIKDAELK---TFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568947207 121 NGFL---LRYAVIKSNHSYCRMFLQRGADTnLGRLEDGQTPLHLSALRDDVLCARMLYNygADTNTRNYEGQTPLAVSI 196
Cdd:PHA02874 187 DNNGespLHNAAEYGDYACIKLLIDHGNHI-MNKCKNGFTPLHNAIIHNRSAIELLINN--ASINDQDIDGSTPLHHAI 262
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 47-196 1.06e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.19  E-value: 1.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  47 RSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNAN---------- 116
Cdd:PHA02874  24 KGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDtsilpipcie 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207 117 -------------IDIQNGFL---LRYAVIKSNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCARMLYNYGAD 180
Cdd:PHA02874 104 kdmiktildcgidVNIKDAELktfLHYAIKKGDLESIKMLFEYGADVNI-EDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182

                        170
                 ....*....|....*.
gi 568947207 181 TNTRNYEGQTPLAVSI 196
Cdd:PHA02874 183 ANVKDNNGESPLHNAA 198
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 125-255 1.16e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 48.83  E-value: 1.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207 125 LRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVsisisgSSRP 204
Cdd:PHA02884  74 LIYAIDCDNDDAAKLLIRYGADVNRYAEEAKITPLYISVLHGCLKCLEILLSYGADINIQTNDMVTPIEL------ALMI 147

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568947207 205 CLDFLQDVTRQpRTLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHK 255
Cdd:PHA02884 148 CNNFLAFMICD-NEISNFYKHPKKILINFDILKILVSHFILQASNDRLNEK 197
SOCS_ASB2 cd03721
SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a ...
 216-255 1.17e-06

SOCS (suppressors of cytokine signaling) box of ASB2-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB2 targets specific proteins to destruction by the proteasome in leukemia cells that have been induced to differentiate. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239691  Cd Length: 45  Bit Score: 44.47  E-value: 1.17e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568947207 216 PRTLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHK 255
Cdd:cd03721    3 PRPLAHLCRLKVRTLIGINRIKLIDTLPLPPRLIRYLNHQ 42
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 138-195 1.20e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.13  E-value: 1.20e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568947207 138 RMFLQRGADTNlGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVS 195
Cdd:PTZ00322  99 RILLTGGADPN-CRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELA 155
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 217-255 1.40e-06

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 43.94  E-value: 1.40e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 568947207   217 RTLQDLCRIKIRQCIGlqnlkLLDELPIAKVMKDYLKHK 255
Cdd:smart00969   1 RSLQHLCRLAIRRSLG-----GIDKLPLPPRLKDYLLYY 34
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 214-255 1.66e-06

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 43.82  E-value: 1.66e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568947207   214 RQPRTLQDLCRIKIRQCIGLQNLKlldELPIAKVMKDYLKHK 255
Cdd:smart00253   5 SNVPSLQHLCRFTIRRCTRTDQIK---TLPLPPKLKDYLSYY 43
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 68-197 1.89e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 48.51  E-value: 1.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  68 YGRDSFVRLLLEFKA-----EVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSY------ 136
Cdd:PHA03100   7 LTKSRIIKVKNIKYIimeddLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvk 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568947207 137 --CRMFLQRGADTNLGRLEdGQTPLH--LSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSIS 197
Cdd:PHA03100  87 eiVKLLLEYGANVNAPDNN-GITPLLyaISKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLE 150
PHA03095 PHA03095
ankyrin-like protein; Provisional
 22-209 2.10e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.10  E-value: 2.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  22 GFTALHY---AAMHGRARIARLMLESEYRsdiINAKSNDGWTPLHVAAHYG-RDSFVRLLLEFKAEVDPLSDKGTTPLQ- 96
Cdd:PHA03095  47 GKTPLHLylhYSSEKVKDIVRLLLEAGAD---VNAPERCGFTPLHLYLYNAtTLDVIKLLIKAGADVNAKDKVGRTPLHv 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  97 -LAIIRERSSCVKILLDHNANIDIQNGFLLR-YAVIKSNHSYC----RMFLQRGADTnLGRLEDGQTPLH--LSALRDDV 168
Cdd:PHA03095 124 yLSGFNINPKVIRLLLRKGADVNALDLYGMTpLAVLLKSRNANvellRLLIDAGADV-YAVDDRFRSLLHhhLQSFKPRA 202

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 568947207 169 LCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFL 209
Cdd:PHA03095 203 RIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVLPL 243
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 51-180 3.94e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 47.75  E-value: 3.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  51 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERS-SCVKILLDHNANIDIQNGFL---LR 126
Cdd:PHA02876 368 VNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPyMSVKTLIDRGANVNSKNKDLstpLH 447

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568947207 127 YAVIKS-NHSYCRMFLQRGADTNLGRLEDgQTPLHLSALRDDVLcaRMLYNYGAD 180
Cdd:PHA02876 448 YACKKNcKLDVIEMLLDNGADVNAINIQN-QYPLLIALEYHGIV--NILLHYGAE 499
Ank_5 pfam13857
Ankyrin repeats (many copies);
45-98 4.11e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.10  E-value: 4.11e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568947207   45 EYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLA 98
Cdd:pfam13857   3 EHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 22-163 4.51e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 47.31  E-value: 4.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  22 GFTALHYAAMHGRARIARLMLEsEYRSDIINAKSND---GWTPLHVAAHYGRDSFVRLLLEFKAEV-------------- 84
Cdd:cd22192   51 GETALHVAALYDNLEAAVVLME-AAPELVNEPMTSDlyqGETALHIAVVNQNLNLVRELIARGADVvspratgtffrpgp 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  85 DPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGF---LLRYAVIKSNHSY-CRMF---LQRGADTNLGRLE---- 153
Cdd:cd22192  130 KNLIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLgntVLHILVLQPNKTFaCQMYdliLSYDKEDDLQPLDlvpn 209

                        170
                 ....*....|.
gi 568947207 154 -DGQTPLHLSA 163
Cdd:cd22192  210 nQGLTPFKLAA 220
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 215-252 5.01e-06

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 42.67  E-value: 5.01e-06
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 568947207 215 QPRTLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYL 252
Cdd:cd03718    2 EPLPLMDLCRRRVRVALGRDRLEEIEQLPLPPSLKNYL 39
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 7-192 8.65e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.60  E-value: 8.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207   7 LSERPSDPTVKDlIGGFTALHYAAMHGRARIARLMLesEYRSDiINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVdp 86
Cdd:PHA02876 164 LLEGGADVNAKD-IYCITPIHYAAERGNAKMVNLLL--SYGAD-VNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNI-- 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  87 lsDKGTTPLQLAIIRERSSCVKILLDHN---ANIDIQNGFLLRYAVikSNHSYCRM---FLQRGADTNLGRLEdGQTPLH 160
Cdd:PHA02876 238 --NKNDLSLLKAIRNEDLETSLLLYDAGfsvNSIDDCKNTPLHHAS--QAPSLSRLvpkLLERGADVNAKNIK-GETPLY 312

                        170       180       190
                 ....*....|....*....|....*....|...
gi 568947207 161 LSALRD-DVLCARMLYNYGADTNTRNYEGQTPL 192
Cdd:PHA02876 313 LMAKNGyDTENIRTLIMLGADVNAADRLYITPL 345
PHA03095 PHA03095
ankyrin-like protein; Provisional
 51-197 2.06e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.40  E-value: 2.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  51 INAKSNDGWTPLHVAAHYGRD---SFVRLLLEFKAEVDPLSDKGTTPLQLaiirersscvkiLLDHNANIDIqngfllry 127
Cdd:PHA03095  40 VNFRGEYGKTPLHLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLHL------------YLYNATTLDV-------- 99

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568947207 128 aviksnhsyCRMFLQRGADTNLgRLEDGQTPLH--LSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSIS 197
Cdd:PHA03095 100 ---------IKLLIKAGADVNA-KDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLK 161
Ank_5 pfam13857
Ankyrin repeats (many copies);
7-65 2.33e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.18  E-value: 2.33e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568947207    7 LSERPSDPTVKDLiGGFTALHYAAMHGRARIARLMLesEYRSDiINAKSNDGWTPLHVA 65
Cdd:pfam13857   2 LEHGPIDLNRLDG-EGYTPLHVAAKYGALEIVRVLL--AYGVD-LNLKDEEGLTALDLA 56
SOCS_ASB14 cd03730
SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a ...
 216-259 3.69e-05

SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239700  Cd Length: 57  Bit Score: 40.60  E-value: 3.69e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 568947207 216 PRTLQDLCRIKIRQCIGLQNLK---LLDELPIAKVMKDYLKHKFDDI 259
Cdd:cd03730    3 PRSLKHLCRLKIRACMGRLRLRcpvFMSFLPLPNRLKAYILYKEYDL 49
Ank_2 pfam12796
Ankyrin repeats (3 copies);
125-197 3.77e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.25  E-value: 3.77e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568947207  125 LRYAVIKSNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCARMLYNYgADTNTRNYeGQTPLAVSIS 197
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANL-QDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAAR 70
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 215-255 4.39e-05

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 39.94  E-value: 4.39e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568947207 215 QPRTLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHK 255
Cdd:cd03743    2 EPLPLMDLCRRSARQALGRHRLHHIQSLPLPQTLKNYLQYQ 42
SOCS_ASB5 cd03724
SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a ...
 216-255 7.31e-05

SOCS (suppressors of cytokine signaling) box of ASB5-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB5 has been implicated in the initiation of arteriogenesis. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239694  Cd Length: 42  Bit Score: 39.48  E-value: 7.31e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568947207 216 PRTLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHK 255
Cdd:cd03724    3 PSSLCQLCRLCIRNYIGRSRLHLIPQLQLPTLLKNFLQYR 42
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 57-85 7.61e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.19  E-value: 7.61e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 568947207   57 DGWTPLHVAA-HYGRDSFVRLLLEFKAEVD 85
Cdd:pfam00023   1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVN 30
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 57-85 1.24e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.39  E-value: 1.24e-04
                          10        20
                  ....*....|....*....|....*....
gi 568947207   57 DGWTPLHVAAHYGRDSFVRLLLEFKAEVD 85
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
SOCS_SOCS1 cd03735
SOCS (suppressors of cytokine signaling) box of SOCS1-like proteins. Together with CIS1, the ...
 214-253 1.34e-04

SOCS (suppressors of cytokine signaling) box of SOCS1-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS1, like CIS1 and SOCS3, is involved in the down-regulation of the JAK/STAT pathway. SOCS1 has a dual function as a direct potent JAK kinase inhibitor and as a component of an E3 ubiquitin-ligase complex recruiting substrates to the protein degradation machinery.


Pssm-ID: 239704  Cd Length: 43  Bit Score: 38.74  E-value: 1.34e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568947207 214 RQPRTLQDLCRIKIRQCIGLQNlklLDELPIAKVMKDYLK 253
Cdd:cd03735    1 VRVRPLQELCRKSIVATFGREN---LARIPLNPVLKDYLK 37
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 216-259 1.95e-04

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 38.27  E-value: 1.95e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 568947207 216 PRTLQDLCRIKIRQCIGLQNLKLL---DELPIAKVMKDYLKHKFDDI 259
Cdd:cd03731    3 PRPLKHLCRLKIRKLMGLQKLQQPssmKKLPLPPALKRYILYKEYDL 49
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 215-252 2.08e-04

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 38.19  E-value: 2.08e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 568947207 215 QPRTLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYL 252
Cdd:cd03723    2 TPRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYL 39
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 57-85 2.75e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 2.75e-04
                           10        20
                   ....*....|....*....|....*....
gi 568947207    57 DGWTPLHVAAHYGRDSFVRLLLEFKAEVD 85
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 90-121 4.95e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.88  E-value: 4.95e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568947207   90 KGTTPLQLAIIRERS-SCVKILLDHNANIDIQN 121
Cdd:pfam00023   1 DGNTPLHLAAGRRGNlEIVKLLLSKGADVNARD 33
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 214-254 8.24e-04

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 36.24  E-value: 8.24e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568947207 214 RQPRTLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKH 254
Cdd:cd03720    1 GNPRSLLSLCRIAVRRALGKQRLSLICSLPLPDPIKKFLLH 41
Ank_5 pfam13857
Ankyrin repeats (many copies);
143-192 1.14e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.17  E-value: 1.14e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 568947207  143 RGADTNLGRLEdGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPL 192
Cdd:pfam13857   5 GPIDLNRLDGE-GYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 154-185 1.14e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.73  E-value: 1.14e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568947207  154 DGQTPLHLSALR-DDVLCARMLYNYGADTNTRN 185
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
Ank_4 pfam13637
Ankyrin repeats (many copies);
91-141 1.31e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.10  E-value: 1.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568947207   91 GTTPLQLAIIRERSSCVKILLDHNANIDIQNGF---LLRYAVIKSNHSYCRMFL 141
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNgetALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 107-197 1.58e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 39.48  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207 107 VKILLDHNANIDIQN----GFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDgQTPLH--LSALRDDVLcaRMLYNYGAD 180
Cdd:PHA02878 150 TKLLLSYGADINMKDrhkgNTALHYATENKDQRLTELLLSYGANVNIPDKTN-NSPLHhaVKHYNKPIV--HILLENGAS 226

                         90
                 ....*....|....*..
gi 568947207 181 TNTRNYEGQTPLAVSIS 197
Cdd:PHA02878 227 TDARDKCGNTPLHISVG 243
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 60-120 2.09e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 38.81  E-value: 2.09e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568947207  60 TPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGT-TPLQLAIIRERSSCVKILLDHNANIDIQ 120
Cdd:PHA02884  72 NPLIYAIDCDNDDAAKLLIRYGADVNRYAEEAKiTPLYISVLHGCLKCLEILLSYGADINIQ 133
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 61-197 2.52e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 38.71  E-value: 2.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207  61 PLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLA-----------IIRERSSC------VKI-LLDHNANIDIQNG 122
Cdd:PHA02878  40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIIckepnklgmkeMIRSINKCsvfytlVAIkDAFNNRNVEIFKI 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207 123 FLLRYavIKSNHS------------------YCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTR 184
Cdd:PHA02878 120 ILTNR--YKNIQTidlvyidkkskddiieaeITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIP 197

                        170
                 ....*....|...
gi 568947207 185 NYEGQTPLAVSIS 197
Cdd:PHA02878 198 DKTNNSPLHHAVK 210
SOCS_ASB13 cd03729
SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a ...
 216-255 2.66e-03

SOCS (suppressors of cytokine signaling) box of ASB13-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239699  Cd Length: 42  Bit Score: 34.76  E-value: 2.66e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568947207 216 PRTLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHK 255
Cdd:cd03729    3 PLSLQQLCRINLRKALGTRALEKIAKLNIPNRIIDYLSYN 42
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 160-213 2.70e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 38.73  E-value: 2.70e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 568947207 160 HLSALRDDVlCARMLYNYGADTNTRNYEGQTPLAVSISIS--GSSRPCLDFLQDVT 213
Cdd:PTZ00322  88 QLAASGDAV-GARILLTGGADPNCRDYDGRTPLHIACANGhvQVVRVLLEFGADPT 142
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 90-119 3.70e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.10  E-value: 3.70e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 568947207    90 KGTTPLQLAIIRERSSCVKILLDHNANIDI 119
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
 215-255 5.37e-03

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 33.93  E-value: 5.37e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568947207 215 QPRTLQDLCRIKIRQcigLQNLKLLDELPIAKVMKDYLKHK 255
Cdd:cd03740    2 QVRSLQYLCRFVIRQ---YTRIDLIQKLPLPNKMKGYLLEK 39
Ank_4 pfam13637
Ankyrin repeats (many copies);
124-174 7.30e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 33.79  E-value: 7.30e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568947207  124 LLRYAVIKSNHSYCRMFLQRGADTNLgRLEDGQTPLHLSALRDDVLCARML 174
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINA-VDGNGETALHFAASNGNVEVLKLL 53
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 22-44 7.51e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.33  E-value: 7.51e-03
                           10        20
                   ....*....|....*....|...
gi 568947207    22 GFTALHYAAMHGRARIARLMLES 44
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDK 24
PHA02917 PHA02917
ankyrin-like protein; Provisional
 51-118 7.67e-03

ankyrin-like protein; Provisional


Pssm-ID: 165231 [Multi-domain]  Cd Length: 661  Bit Score: 37.28  E-value: 7.67e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568947207  51 INAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERS-SCVKILLDHNANID 118
Cdd:PHA02917 445 INMIDKRGETLLHKAVRYNKQSLVSLLLESGSDVNIRSNNGYTCIAIAINESRNiELLKMLLCHKPTLD 513
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 137-195 8.70e-03

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 36.01  E-value: 8.70e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947207 137 CRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNY-GADTNTRNYEGQTPLAVS 195
Cdd:PHA02736  74 LKLLMEWGADINGKERVFGNTPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYYVA 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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