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Conserved domains on  [gi|568946705|ref|XP_006540491|]
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sulfotransferase 2A8 isoform X1 [Mus musculus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
34-275 3.47e-86

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 258.04  E-value: 3.47e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946705   34 DEDTIIVTYPKSGTHWLNEIVCLILTKGDPTWVQS---TIANERTPWIEF---------ENNYRILNSKEGPRLMASLLP 101
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEphlFNNHNRSPFLEWypgdtyfdvAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946705  102 IQLFPKSFFSSKAKVIYLIRNPRDVLVSGYHYFNALKQGKEQVPWKIYFENFLQGKSYFGSWFEHACGWISLRKRENILV 181
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946705  182 LSYEQLKKDTRNTIKKICEFLGENLESGELELVLKNISFQIMKERMISQSCLSNIEKHEFiMRKGITGDWKNHFTVAQAE 261
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEVSPF-FRKGLVGDWKNYFTPEQAE 239

                         250
                  ....*....|....
gi 568946705  262 AFDKAFQEKAADFP 275
Cdd:pfam00685 240 KFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
34-275 3.47e-86

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 258.04  E-value: 3.47e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946705   34 DEDTIIVTYPKSGTHWLNEIVCLILTKGDPTWVQS---TIANERTPWIEF---------ENNYRILNSKEGPRLMASLLP 101
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEphlFNNHNRSPFLEWypgdtyfdvAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946705  102 IQLFPKSFFSSKAKVIYLIRNPRDVLVSGYHYFNALKQGKEQVPWKIYFENFLQGKSYFGSWFEHACGWISLRKRENILV 181
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946705  182 LSYEQLKKDTRNTIKKICEFLGENLESGELELVLKNISFQIMKERMISQSCLSNIEKHEFiMRKGITGDWKNHFTVAQAE 261
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEVSPF-FRKGLVGDWKNYFTPEQAE 239

                         250
                  ....*....|....
gi 568946705  262 AFDKAFQEKAADFP 275
Cdd:pfam00685 240 KFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 27-270 2.51e-21

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 91.91  E-value: 2.51e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946705  27 RDRFVVRDEDTIIVTYPKSGTHWLNEIVCLI------------LTKGDPtwvqstiaNERTPWIE----FENNYRILNSK 90
Cdd:PLN02164  72 QEFFQARPNDFLVCSYPKTGTTWLKALTFAIanrsrfddssnpLLKRNP--------HEFVPYIEidfpFFPSVDVLKDK 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946705  91 EGPrLMASLLPIQLFPKSFFSSKAKVIYLIRNPRDVLVSGYHYFNalKQGKEQVP---WKIYFENFLQGKSYFGSWFEHA 167
Cdd:PLN02164 144 GNT-LFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLH--KERSQQGPlnsLEESFDMFCRGLSVYGPYLDHV 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946705 168 CG-WISLRKREN-ILVLSYEQLKKDTRNTIKKICEFLG-----ENLESGELELVLKNISFQIM---------KERMISQS 231
Cdd:PLN02164 221 LGyWKAYQENPDrILFLKYETMRADPLPYVKRLAEFMGygftaEEEEKGVVEKVVKLCSFETLknleankgeKDREDRPA 300

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 568946705 232 CLSNiekhEFIMRKGITGDWKNHFTVAQAEAFDKAFQEK 270
Cdd:PLN02164 301 VYAN----SAYFRKGKVGDWQNYLTPEMAARIDGLMEEK 335
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
34-275 3.47e-86

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 258.04  E-value: 3.47e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946705   34 DEDTIIVTYPKSGTHWLNEIVCLILTKGDPTWVQS---TIANERTPWIEF---------ENNYRILNSKEGPRLMASLLP 101
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEphlFNNHNRSPFLEWypgdtyfdvAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946705  102 IQLFPKSFFSSKAKVIYLIRNPRDVLVSGYHYFNALKQGKEQVPWKIYFENFLQGKSYFGSWFEHACGWISLRKRENILV 181
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946705  182 LSYEQLKKDTRNTIKKICEFLGENLESGELELVLKNISFQIMKERMISQSCLSNIEKHEFiMRKGITGDWKNHFTVAQAE 261
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEVSPF-FRKGLVGDWKNYFTPEQAE 239

                         250
                  ....*....|....
gi 568946705  262 AFDKAFQEKAADFP 275
Cdd:pfam00685 240 KFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 27-270 2.51e-21

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 91.91  E-value: 2.51e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946705  27 RDRFVVRDEDTIIVTYPKSGTHWLNEIVCLI------------LTKGDPtwvqstiaNERTPWIE----FENNYRILNSK 90
Cdd:PLN02164  72 QEFFQARPNDFLVCSYPKTGTTWLKALTFAIanrsrfddssnpLLKRNP--------HEFVPYIEidfpFFPSVDVLKDK 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946705  91 EGPrLMASLLPIQLFPKSFFSSKAKVIYLIRNPRDVLVSGYHYFNalKQGKEQVP---WKIYFENFLQGKSYFGSWFEHA 167
Cdd:PLN02164 144 GNT-LFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLH--KERSQQGPlnsLEESFDMFCRGLSVYGPYLDHV 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946705 168 CG-WISLRKREN-ILVLSYEQLKKDTRNTIKKICEFLG-----ENLESGELELVLKNISFQIM---------KERMISQS 231
Cdd:PLN02164 221 LGyWKAYQENPDrILFLKYETMRADPLPYVKRLAEFMGygftaEEEEKGVVEKVVKLCSFETLknleankgeKDREDRPA 300

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 568946705 232 CLSNiekhEFIMRKGITGDWKNHFTVAQAEAFDKAFQEK 270
Cdd:PLN02164 301 VYAN----SAYFRKGKVGDWQNYLTPEMAARIDGLMEEK 335
Sulfotransfer_3 pfam13469
Sulfotransferase family;
103-203 7.22e-08

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 51.14  E-value: 7.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946705  103 QLFPKsffsskAKVIYLIRNPRDVLVSGYHYFNALKQGKEQVPWKIYFENFLQGksyfgsWFEHACGWISLRKR---ENI 179
Cdd:pfam13469  77 KAFPD------AKFIHLHRDPVDTVISSYCSLFGFTLSSYSTAFLRDIGLALAR------WSRAYERLMAARARvppGRF 144

                          90       100
                  ....*....|....*....|....
gi 568946705  180 LVLSYEQLKKDTRNTIKKICEFLG 203
Cdd:pfam13469 145 LDVRYEDLVADPEGTLRRILEFLG 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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