First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM); The members here are composed of the immunoglobulin (Ig)-like domain 1 in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) proteins. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946111  33 IESLPPQVVEGENVLLRVDNLPENLLGFIWYKGVT-DMSLGIALYSLTYSRGVTGPVHSGRETLYRNGSLWIQNVTQEDT 111
Cdd:cd05774    3 IELVPPQVAEGENVLLLVHNLPENLLAYAWYKGKTvSPNFLIASYIISTNSSTPGPAYSGRETIYPNGSLLIQNVTQKDT 82

                         90       100
                 ....*....|....*....|....
gi 568946111 112 GFYTLRTISKRGEiISNTSMHLHV 135
Cdd:cd05774   83 GFYTLQTITADLQ-TEQASVHLQV 105

First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM); The members here are composed of the immunoglobulin (Ig)-like domain 1 in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) proteins. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946111  33 IESLPPQVVEGENVLLRVDNLPENLLGFIWYKGVT-DMSLGIALYSLTYSRGVTGPVHSGRETLYRNGSLWIQNVTQEDT 111
Cdd:cd05774    3 IELVPPQVAEGENVLLLVHNLPENLLAYAWYKGKTvSPNFLIASYIISTNSSTPGPAYSGRETIYPNGSLLIQNVTQKDT 82

                         90       100
                 ....*....|....*....|....
gi 568946111 112 GFYTLRTISKRGEiISNTSMHLHV 135
Cdd:cd05774   83 GFYTLQTITADLQ-TEQASVHLQV 105

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946111   33 IESLPPQVVEGENVLLRV---DNLPENLLGFIWYKGVTDMSLG--IALYSLTYSRGVTGPVHSGRETL-YRNGSLWIQNV 106
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCtysSSMSEASTSVYWYRQPPGKGPTflIAYYSNGSEEGVKKGRFSGRGDPsNGDGSLTIQNL 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 568946111  107 TQEDTGFYTLRTISKrGEIISNTSMHLHVY 136
Cdd:pfam07686  81 TLSDSGTYTCAVIPS-GEGVFGKGTRLTVL 109

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946111    40 VVEGENVLL--RVDNLPENllGFIWYKGvtdmslgialysltysrGVTGPVHSGRETLYRNG---SLWIQNVTQEDTGFY 114
Cdd:smart00410   6 VKEGESVTLscEASGSPPP--EVTWYKQ-----------------GGKLLAESGRFSVSRSGstsTLTISNVTPEDSGTY 66

                           90       100
                   ....*....|....*....|.
gi 568946111   115 TLRTISKRGEIISNTsmHLHV 135
Cdd:smart00410  67 TCAATNSSGSASSGT--TLTV 85

First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM); The members here are composed of the immunoglobulin (Ig)-like domain 1 in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) proteins. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946111  33 IESLPPQVVEGENVLLRVDNLPENLLGFIWYKGVT-DMSLGIALYSLTYSRGVTGPVHSGRETLYRNGSLWIQNVTQEDT 111
Cdd:cd05774    3 IELVPPQVAEGENVLLLVHNLPENLLAYAWYKGKTvSPNFLIASYIISTNSSTPGPAYSGRETIYPNGSLLIQNVTQKDT 82

                         90       100
                 ....*....|....*....|....
gi 568946111 112 GFYTLRTISKRGEiISNTSMHLHV 135
Cdd:cd05774   83 GFYTLQTITADLQ-TEQASVHLQV 105

Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and related domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface. This family corresponds to the D1 Ig-like domain. Also belonging to this group is the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84-like family. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. SLAM family proteins are organized as an extracellular domain with having two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946111  38 PQVVEGENVLLRVDNLPENLLGFIWYKG-VTDMSLGIALYSLTYSRGVTGPVHSGRETLYRNGSLWIQNVTQEDTGFYTL 116
Cdd:cd05741    5 FYGAEGKNVLLLVPNLQTPLKSVSWYKGkQVSRNDEIAEYENSSDEFRAGSAFSGREYIYTNGSLLIQNITLSDTGFYTL 84

                         90
                 ....*....|....*....
gi 568946111 117 RTIsKRGEIISNTSMHLHV 135
Cdd:cd05741   85 EST-NIGGKTESATFQLHV 102

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946111   33 IESLPPQVVEGENVLLRV---DNLPENLLGFIWYKGVTDMSLG--IALYSLTYSRGVTGPVHSGRETL-YRNGSLWIQNV 106
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCtysSSMSEASTSVYWYRQPPGKGPTflIAYYSNGSEEGVKKGRFSGRGDPsNGDGSLTIQNL 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 568946111  107 TQEDTGFYTLRTISKrGEIISNTSMHLHVY 136
Cdd:pfam07686  81 TLSDSGTYTCAVIPS-GEGVFGKGTRLTVL 109

Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and related domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions: it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two (D1, D4) or four (D1-D4) Ig-like domains on the cell surface. This family corresponds to the D1 Ig-like domain. Also belonging to this group is the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84-like family. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. SLAM family proteins are organized as an extracellular domain with having two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 568946111 279 SVAEGESVLLLVHNLPENLRAVFWYKGAIVFKDLEVARL 317
Cdd:cd05741    6 YGAEGKNVLLLVPNLQTPLKSVSWYKGKQVSRNDEIAEY 44

Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain of hemolin and similar proteins. Hemolin, an insect immunoglobulin superfamily (IgSF) member containing four Ig-like domains, is a lipopolysaccharide-binding immune protein induced during bacterial infection. Hemolin shares significant sequence similarity with the first four Ig-like domains of the transmembrane cell adhesion molecules (CAMs) of the L1 family. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The fourth Ig-like domain of hemolin is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568946111  84 VTGPV-------HSGRE-------TLYRNGSLWIQNVTQEDTGFYTLRTISKRGEIISNTSMH 132
Cdd:cd20978   25 VTGVPqpkitwlHNGKPlqgpmerATVEDGTLTIINVQPEDTGYYGCVATNEIGDIYTETLLH 87

Immunoglobulin domain; This family contains immunoglobulin-like domains.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946111  145 PPtsaQLSIESVPPSVAKGESVLL--LARNLPENlrAIFWYKGaivfknlevaryviakNSSVLGPAHSGREIMYSNGSL 222
Cdd:pfam13927   1 KP---VITVSPSSVTVREGETVTLtcEATGSPPP--TITWYKN----------------GEPISSGSTRSRSLSGSNSTL 59

                          90
                  ....*....|....
gi 568946111  223 VLQNVTRNDAGFYT 236
Cdd:pfam13927  60 TISNVTRSDAGTYT 73

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946111 161 AKGESVLLLARNLPENLRAIFWYKGAIvfknlEVARYVIAKNSSVLGPAHSGREIMYSNGSLVLQNVTRNDAGFYTLRTL 240
Cdd:cd05775    8 ALGGNVTLTISSLQDDIDEIKWKKTKD-----KIVEWENNIGPTYFGSFKDRVLLDKESGSLTIKNLTKEDSGTYELEIT 82

                         90
                 ....*....|....*
gi 568946111 241 STDLKAEVAHVQLQV 255
Cdd:cd05775   83 STNGKVLSSKFTLEV 97

Fifth immunoglobulin (Ig) domain of contactin; The members here are composed of the fifth immunoglobulin (Ig) domain of contactins. Contactins are neural cell adhesion molecules and are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. The first four Ig domains form the intermolecular binding fragment, which arranges as a compact U-shaped module via contacts between Ig domains 1 and 4, and between Ig domains 2 and 3. Contactin-2 (TAG-1, axonin-1) may play a part in the neuronal processes of neurite outgrowth, axon guidance and fasciculation, and neuronal migration. This group also includes contactin-1 and contactin-5. The different contactins show different expression patterns in the central nervous system. During development and in adulthood, contactin-2 is transiently expressed in subsets of central and peripheral neurons. Contactin-5 is expressed specifically in the rat postnatal nervous system, peaking at about 3 weeks postnatal, and a lack of contactin-5 (NB-2) results in an impairment of neuronal activity in the rat auditory system. Contactin-5 is highly expressed in the adult human brain in the occipital lobe and in the amygdala. Contactin-1 is differentially expressed in tumor tissues and may, through a RhoA mechanism, facilitate invasion and metastasis of human lung adenocarcinoma.

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 568946111  77 SLTYSRGVTGPVHSGRETLYRNGSLWIQNVTQEDTGFYT 115
Cdd:cd04969   33 TISWSKGTELLTNSSRICILPDGSLKIKNVTKSDEGKYT 71