NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568932020|ref|XP_006539300|]
View 

polyamine-transporting ATPase 13A2 isoform X2 [Mus musculus]

Protein Classification

cation-translocating P-type ATPase( domain architecture ID 11492996)

cation-translocating P-type ATPase is an integral membrane transporter that generates and maintains electrochemical gradients across cellular membranes by translocating cations or heavy metals, and is distinguished from other transport ATPases (F-, V-, and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle; similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
35-1150 0e+00

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


:

Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 1282.31  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020    35 VRLSGYCGSPWRAIGYHAAVWMLAGIPWLLFRWKPLWGVRLRLKPCSLAHAETLVIEIKdkegssrqlftvqvQTEAVVQ 114
Cdd:TIGR01657    4 IGISAYKISPFKLIIYLVTLILTFGLVLLLLTWLPEWKVKLRYVPVSNEDAETVVIVDP--------------TPNSGSD 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   115 GSLELPPQAQAEDGRSQAAVGVTPEGTWQDTSELHRQEEAVSGQlgsrprlvllwasrshavwedwahgslcpsgslwsr 194
Cdd:TIGR01657   70 YIVELSNKSLSNDLQTENAVEGGEEPIYFDFRKQRFSYHEKELK------------------------------------ 113
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   195 rpvilsdrqaslshdaiplpsptlcvwmlharppptglssltqkqvlryyvlqgqryVWMETQQAFCQVSlldHGRTCDD 274
Cdd:TIGR01657  114 ---------------------------------------------------------IFSPLPYLFKEKS---FGVYSTC 133
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   275 VHcSSSGLSLQDQATRKTIYGPNVISIPVKSYLQLLADEALNPYYGFQAFSIALWLADHYYWYALCIFLISAISICLALY 354
Cdd:TIGR01657  134 AG-HSNGLTTGDIAQRKAKYGKNEIEIPVPSFLELLKEEVLHPFYVFQVFSVILWLLDEYYYYSLCIVFMSSTSISLSVY 212
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   355 KTRKQSLTLRDMVKLSVRVQVCRPGgEEEWVDSSELVPGDCLVLP-QEGGVMPCDAALVAGECVVNESSLTGESTPVLKT 433
Cdd:TIGR01657  213 QIRKQMQRLRDMVHKPQSVIVIRNG-KWVTIASDELVPGDIVSIPrPEEKTMPCDSVLLSGSCIVNESMLTGESVPVLKF 291
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   434 ALPEG----PKPYCPETHRRHTLFCGTLILQARAYVGPR-VLAVVTRTGFCTAKGGLVSSILHPRPISFKFYKHSMKFVA 508
Cdd:TIGR01657  292 PIPDNgdddEDLFLYETSKKHVLFGGTKILQIRPYPGDTgCLAIVVRTGFSTSKGQLVRSILYPKPRVFKFYKDSFKFIL 371
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   509 ALSVLALLGTVYSIIILYRNRVPVREIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLV 588
Cdd:TIGR01657  372 FLAVLALIGFIYTIIELIKDGRPLGKIILRSLDIITIVVPPALPAELSIGINNSLARLKKKGIFCTSPFRINFAGKIDVC 451
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   589 CFDKTGTLTEDGLDVMGVVPLKG-QVLLPLVPEPCHLPLGPLLRALATCHALSQLHDTPVGDPMDLKMVESTGWVLEEgp 667
Cdd:TIGR01657  452 CFDKTGTLTEDGLDLRGVQGLSGnQEFLKIVTEDSSLKPSITHKALATCHSLTKLEGKLVGDPLDKKMFEATGWTLEE-- 529
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   668 AAGSAPGSQVLVVMRpppggprqQEEPPVPVSVLCRFPFSSALQRMDVVVTWPGATQPEAYVKGSPELVASLCSPETVPS 747
Cdd:TIGR01657  530 DDESAEPTSILAVVR--------TDDPPQELSIIRRFQFSSALQRMSVIVSTNDERSPDAFVKGAPETIQSLCSPETVPS 601
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   748 DFSQVLQSYTAAGYRVVALAGKPLPiAPSLAAAQQLTRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTG 827
Cdd:TIGR01657  602 DYQEVLKSYTREGYRVLALAYKELP-KLTLQKAQDLSRDAVESNLTFLGFIVFENPLKPDTKEVIKELKRASIRTVMITG 680
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   828 DNLQTAVTVARACGMVGAQEHLAVIHATHPEQGQPAALEFLPTESSAVMNGAKATGYP----TVPEPQSC--HLALSGST 901
Cdd:TIGR01657  681 DNPLTAVHVARECGIVNPSNTLILAEAEPPESGKPNQIKFEVIDSIPFASTQVEIPYPlgqdSVEDLLASryHLAMSGKA 760
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   902 FAVLRKHFPKLLPKVLVQATVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSS 981
Cdd:TIGR01657  761 FAVLQAHSPELLLRLLSHTTVFARMAPDQKETLVELLQKLDYTVGMCGDGANDCGALKQADVGISLSEAEASVAAPFTSK 840
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   982 MASIECVPTVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALTLVR 1061
Cdd:TIGR01657  841 LASISCVPNVIREGRCALVTSFQMFKYMALYSLIQFYSVSILYLIGSNLGDGQFLTIDLLLIFPVALLMSRNKPLKKLSK 920
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  1062 ARPPGALLSVPVLGSLLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVPAPDNLPNYENTVVFSLSGFQYLILAAAVSKGA 1141
Cdd:TIGR01657  921 ERPPSNLFSVYILTSVLIQFVLHILSQVYLVFELHAQPWYKPENPVDLEKENFPNLLNTVLFFVSSFQYLITAIVNSKGP 1000

                   ....*....
gi 568932020  1142 PFRQPLYTN 1150
Cdd:TIGR01657 1001 PFREPIYKN 1009
 
Name Accession Description Interval E-value
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
35-1150 0e+00

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 1282.31  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020    35 VRLSGYCGSPWRAIGYHAAVWMLAGIPWLLFRWKPLWGVRLRLKPCSLAHAETLVIEIKdkegssrqlftvqvQTEAVVQ 114
Cdd:TIGR01657    4 IGISAYKISPFKLIIYLVTLILTFGLVLLLLTWLPEWKVKLRYVPVSNEDAETVVIVDP--------------TPNSGSD 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   115 GSLELPPQAQAEDGRSQAAVGVTPEGTWQDTSELHRQEEAVSGQlgsrprlvllwasrshavwedwahgslcpsgslwsr 194
Cdd:TIGR01657   70 YIVELSNKSLSNDLQTENAVEGGEEPIYFDFRKQRFSYHEKELK------------------------------------ 113
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   195 rpvilsdrqaslshdaiplpsptlcvwmlharppptglssltqkqvlryyvlqgqryVWMETQQAFCQVSlldHGRTCDD 274
Cdd:TIGR01657  114 ---------------------------------------------------------IFSPLPYLFKEKS---FGVYSTC 133
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   275 VHcSSSGLSLQDQATRKTIYGPNVISIPVKSYLQLLADEALNPYYGFQAFSIALWLADHYYWYALCIFLISAISICLALY 354
Cdd:TIGR01657  134 AG-HSNGLTTGDIAQRKAKYGKNEIEIPVPSFLELLKEEVLHPFYVFQVFSVILWLLDEYYYYSLCIVFMSSTSISLSVY 212
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   355 KTRKQSLTLRDMVKLSVRVQVCRPGgEEEWVDSSELVPGDCLVLP-QEGGVMPCDAALVAGECVVNESSLTGESTPVLKT 433
Cdd:TIGR01657  213 QIRKQMQRLRDMVHKPQSVIVIRNG-KWVTIASDELVPGDIVSIPrPEEKTMPCDSVLLSGSCIVNESMLTGESVPVLKF 291
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   434 ALPEG----PKPYCPETHRRHTLFCGTLILQARAYVGPR-VLAVVTRTGFCTAKGGLVSSILHPRPISFKFYKHSMKFVA 508
Cdd:TIGR01657  292 PIPDNgdddEDLFLYETSKKHVLFGGTKILQIRPYPGDTgCLAIVVRTGFSTSKGQLVRSILYPKPRVFKFYKDSFKFIL 371
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   509 ALSVLALLGTVYSIIILYRNRVPVREIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLV 588
Cdd:TIGR01657  372 FLAVLALIGFIYTIIELIKDGRPLGKIILRSLDIITIVVPPALPAELSIGINNSLARLKKKGIFCTSPFRINFAGKIDVC 451
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   589 CFDKTGTLTEDGLDVMGVVPLKG-QVLLPLVPEPCHLPLGPLLRALATCHALSQLHDTPVGDPMDLKMVESTGWVLEEgp 667
Cdd:TIGR01657  452 CFDKTGTLTEDGLDLRGVQGLSGnQEFLKIVTEDSSLKPSITHKALATCHSLTKLEGKLVGDPLDKKMFEATGWTLEE-- 529
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   668 AAGSAPGSQVLVVMRpppggprqQEEPPVPVSVLCRFPFSSALQRMDVVVTWPGATQPEAYVKGSPELVASLCSPETVPS 747
Cdd:TIGR01657  530 DDESAEPTSILAVVR--------TDDPPQELSIIRRFQFSSALQRMSVIVSTNDERSPDAFVKGAPETIQSLCSPETVPS 601
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   748 DFSQVLQSYTAAGYRVVALAGKPLPiAPSLAAAQQLTRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTG 827
Cdd:TIGR01657  602 DYQEVLKSYTREGYRVLALAYKELP-KLTLQKAQDLSRDAVESNLTFLGFIVFENPLKPDTKEVIKELKRASIRTVMITG 680
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   828 DNLQTAVTVARACGMVGAQEHLAVIHATHPEQGQPAALEFLPTESSAVMNGAKATGYP----TVPEPQSC--HLALSGST 901
Cdd:TIGR01657  681 DNPLTAVHVARECGIVNPSNTLILAEAEPPESGKPNQIKFEVIDSIPFASTQVEIPYPlgqdSVEDLLASryHLAMSGKA 760
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   902 FAVLRKHFPKLLPKVLVQATVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSS 981
Cdd:TIGR01657  761 FAVLQAHSPELLLRLLSHTTVFARMAPDQKETLVELLQKLDYTVGMCGDGANDCGALKQADVGISLSEAEASVAAPFTSK 840
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   982 MASIECVPTVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALTLVR 1061
Cdd:TIGR01657  841 LASISCVPNVIREGRCALVTSFQMFKYMALYSLIQFYSVSILYLIGSNLGDGQFLTIDLLLIFPVALLMSRNKPLKKLSK 920
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  1062 ARPPGALLSVPVLGSLLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVPAPDNLPNYENTVVFSLSGFQYLILAAAVSKGA 1141
Cdd:TIGR01657  921 ERPPSNLFSVYILTSVLIQFVLHILSQVYLVFELHAQPWYKPENPVDLEKENFPNLLNTVLFFVSSFQYLITAIVNSKGP 1000

                   ....*....
gi 568932020  1142 PFRQPLYTN 1150
Cdd:TIGR01657 1001 PFREPIYKN 1009
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
285-1118 0e+00

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 1183.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  285 QDQATRKTIYGPNVISIPVKSYLQLLADEALNPYYGFQAFSIALWLADHYYWYALCIFLISAISICLALYKTRKQSLTLR 364
Cdd:cd07542     1 DEQSDRRLIYGPNEIDVPLKSILKLLFKEVLNPFYVFQLFSVILWSSDDYYYYAACIVIISVISIFLSLYETRKQSKRLR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  365 DMVKLSVRVQVCRPGgEEEWVDSSELVPGDCLVLPQEGGVMPCDAALVAGECVVNESSLTGESTPVLKTALPEG-----P 439
Cdd:cd07542    81 EMVHFTCPVRVIRDG-EWQTISSSELVPGDILVIPDNGTLLPCDAILLSGSCIVNESMLTGESVPVTKTPLPDEsndslW 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  440 KPYCPETHRRHTLFCGTLILQARAYVGPRVLAVVTRTGFCTAKGGLVSSILHPRPISFKFYKHSMKFVAALSVLALLGTV 519
Cdd:cd07542   160 SIYSIEDHSKHTLFCGTKVIQTRAYEGKPVLAVVVRTGFNTTKGQLVRSILYPKPVDFKFYRDSMKFILFLAIIALIGFI 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  520 YSIIILYRNRVPVREIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFDKTGTLTED 599
Cdd:cd07542   240 YTLIILILNGESLGEIIIRALDIITIVVPPALPAALTVGIIYAQSRLKKKGIFCISPQRINICGKINLVCFDKTGTLTED 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  600 GLDVMGVVPLKGQVLLPLVPEPC------HLPLGPLLRALATCHALSQLHDTPVGDPMDLKMVESTGWVLEegpaagsap 673
Cdd:cd07542   320 GLDLWGVRPVSGNNFGDLEVFSLdldldsSLPNGPLLRAMATCHSLTLIDGELVGDPLDLKMFEFTGWSLE--------- 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  674 gsqvlvvmrpppggprqqeeppvpvsVLCRFPFSSALQRMDVVVTWPGATQPEAYVKGSPELVASLCSPETVPSDFSQVL 753
Cdd:cd07542   391 --------------------------ILRQFPFSSALQRMSVIVKTPGDDSMMAFTKGAPEMIASLCKPETVPSNFQEVL 444
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  754 QSYTAAGYRVVALAGKPLPIAPSLaaAQQLTRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTA 833
Cdd:cd07542   445 NEYTKQGFRVIALAYKALESKTWL--LQKLSREEVESDLEFLGLIVMENRLKPETAPVINELNRANIRTVMVTGDNLLTA 522
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  834 VTVARACGMVGAQEHLAVIHATHPEQGQPAALEFlptessavmngakatgyptvpepqschlalsgstfavlrkhfpkll 913
Cdd:cd07542   523 ISVARECGMISPSKKVILIEAVKPEDDDSASLTW---------------------------------------------- 556
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  914 pKVLVQATVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPTVIR 993
Cdd:cd07542   557 -TLLLKGTVFARMSPDQKSELVEELQKLDYTVGMCGDGANDCGALKAADVGISLSEAEASVAAPFTSKVPDISCVPTVIK 635
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  994 EGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALTLVRARPPGALLSVPV 1073
Cdd:cd07542   636 EGRAALVTSFSCFKYMALYSLIQFISVLILYSINSNLGDFQFLFIDLVIITPIAVFMSRTGAYPKLSSKRPPASLVSPPV 715
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....*
gi 568932020 1074 LGSLLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVPAPDNLPNYE 1118
Cdd:cd07542   716 LVSLLGQIVLILLFQVIGFLIVRQQPWYIPPEPTVDKANTDNSNE 760
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
266-1098 3.67e-77

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 273.52  E-value: 3.67e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  266 LDHGRTCDDVHCSSSGLSLQDQATRKTIYGPNVISIPVK-SYLQLLADEALNPyygfqaFSIALWLA-------DHYYwY 337
Cdd:COG0474    11 LSAEEVLAELGTSEEGLSSEEAARRLARYGPNELPEEKKrSLLRRFLEQFKNP------LILILLAAavisallGDWV-D 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  338 ALCIFLISAISICLALYKTRK--QSLT-LRDMVklSVRVQVCRpGGEEEWVDSSELVPGDCLVLpQEGGVMPCDAALV-A 413
Cdd:COG0474    84 AIVILAVVLLNAIIGFVQEYRaeKALEaLKKLL--APTARVLR-DGKWVEIPAEELVPGDIVLL-EAGDRVPADLRLLeA 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  414 GECVVNESSLTGESTPVLKTALPEGPKPycPETHRRHTLFCGTLILQARAyvgprvLAVVTRTGFCTAKGGLVSSI--LH 491
Cdd:COG0474   160 KDLQVDESALTGESVPVEKSADPLPEDA--PLGDRGNMVFMGTLVTSGRG------TAVVVATGMNTEFGKIAKLLqeAE 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  492 PRPISFKfyKHSMKFVAALSVLAL-LGTVYSIIILYRNRvPVREIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQG 570
Cdd:COG0474   232 EEKTPLQ--KQLDRLGKLLAIIALvLAALVFLIGLLRGG-PLLEALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRN 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  571 IfcihplrI--------NLGGkLRLVCFDKTGTLTEDGLDVMGVVPLKGQVLLPLVPEPchlPLGPLLRALATCHALSQL 642
Cdd:COG0474   309 A-------IvrrlpaveTLGS-VTVICTDKTGTLTQNKMTVERVYTGGGTYEVTGEFDP---ALEELLRAAALCSDAQLE 377
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  643 HDTPVGDPMDlkmvestGWVLEEGPAAGsapgsqvLVVMRPPPGGPRQQEeppvpvsvlcrFPFSSALQRMDVVVTWPGA 722
Cdd:COG0474   378 EETGLGDPTE-------GALLVAAAKAG-------LDVEELRKEYPRVDE-----------IPFDSERKRMSTVHEDPDG 432
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  723 tQPEAYVKGSPELVASLCS-----------PETVPSDFSQVLQSYTAAGYRVVALAGKPLPiapslaAAQQLTRDTVERE 791
Cdd:COG0474   433 -KRLLIVKGAPEVVLALCTrvltgggvvplTEEDRAEILEAVEELAAQGLRVLAVAYKELP------ADPELDSEDDESD 505
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  792 LSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTVARACGMVGAQEHlaVIHAthpeqgqpAALEflpte 871
Cdd:COG0474   506 LTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR--VLTG--------AELD----- 570
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  872 ssavmngakatgyptvpepqschlALSGSTFAvlrkhfpkllpKVLVQATVFARMAPEQKTELVCELQRLQYCVGMCGDG 951
Cdd:COG0474   571 ------------------------AMSDEELA-----------EAVEDVDVFARVSPEHKLRIVKALQANGHVVAMTGDG 615
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  952 ANDCGALKAADVGISLSQA------EAsvvspftSSM-------ASIEcvpTVIREGRcsldtsfSVF----KYmalysl 1014
Cdd:COG0474   616 VNDAPALKAADIGIAMGITgtdvakEA-------ADIvllddnfATIV---AAVEEGR-------RIYdnirKF------ 672
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020 1015 tqfisvlILYTINTNLGD------------------LQFLAIDLVITTTvavlmsrtgPALTL--------VRARPP--- 1065
Cdd:COG0474   673 -------IKYLLSSNFGEvlsvllasllglplpltpIQILWINLVTDGL---------PALALgfepvepdVMKRPPrwp 736
                         890       900       910
                  ....*....|....*....|....*....|....
gi 568932020 1066 -GALLSVPVLGSLLLQVALVAGIQLGGYFLVIAQ 1098
Cdd:COG0474   737 dEPILSRFLLLRILLLGLLIAIFTLLTFALALAR 770
E1-E2_ATPase pfam00122
E1-E2 ATPase;
369-566 1.48e-31

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 121.91  E-value: 1.48e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   369 LSVRVQVCRPGGEEEwVDSSELVPGDcLVLPQEGGVMPCDAALVAGECVVNESSLTGESTPVLKtalpegpkpycpetHR 448
Cdd:pfam00122    3 LPPTATVLRDGTEEE-VPADELVPGD-IVLLKPGERVPADGRIVEGSASVDESLLTGESLPVEK--------------KK 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   449 RHTLFCGTLILQARAyvgprvLAVVTRTGFCTAKGGLVSSILHPRPISFKFYKHSMKFVAALSVLALLGTVYSIIILYRN 528
Cdd:pfam00122   67 GDMVYSGTVVVSGSA------KAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWLFV 140
                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 568932020   529 RVPVREIVIRALDLVTVVVPPALPAAMTVCTLYAQSRL 566
Cdd:pfam00122  141 GGPPLRALLRALAVLVAACPCALPLATPLALAVGARRL 178
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
262-970 2.50e-26

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 117.09  E-value: 2.50e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  262 QVSLLDHGRTCDDVHCSSSGLSLQDQATRKTIYGPNVISI--PVKSYLQLLaDEALNPyygfqaFSIALWLADHYYWY-- 337
Cdd:PRK10517   48 KAAVMPEEELWKTFDTHPEGLNEAEVESAREQHGENELPAqkPLPWWVHLW-VCYRNP------FNILLTILGAISYAte 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  338 ----ALCIFLISAISICLALY---KTRKQSLTLRDMVKLSVRVQVCRPG-GEEEWVDS--SELVPGDCLVLpQEGGVMPC 407
Cdd:PRK10517  121 dlfaAGVIALMVAISTLLNFIqeaRSTKAADALKAMVSNTATVLRVINDkGENGWLEIpiDQLVPGDIIKL-AAGDMIPA 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  408 DA-ALVAGECVVNESSLTGESTPVLKTALPEGPKPYCPethrrhtLFCGTLILQARAYVGPRVLAVVTRTGFCTAKGGLV 486
Cdd:PRK10517  200 DLrILQARDLFVAQASLTGESLPVEKFATTRQPEHSNP-------LECDTLCFMGTNVVSGTAQAVVIATGANTWFGQLA 272
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  487 SSILHP--RPISFKF--YKHSMKFVAALSVLAllgtvysIIILYRN---RVPVREIVIRALDLVTVVVPPALPaaMTVCT 559
Cdd:PRK10517  273 GRVSEQdsEPNAFQQgiSRVSWLLIRFMLVMA-------PVVLLINgytKGDWWEAALFALSVAVGLTPEMLP--MIVTS 343
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  560 LYAQS--RLRTQGIFCIHPLRINLGGKLRLVCFDKTGTLTEDGL------DVMGvvplkgqvllplvpEPCHlplGPLLR 631
Cdd:PRK10517  344 TLARGavKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKIvlenhtDISG--------------KTSE---RVLHS 406
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  632 ALATCH---ALSQLHDTPVGDPMDL--KMVESTGWvleegpaagsapgsqvlvvmrpppggpRQQEEppvpvsvlcrFPF 706
Cdd:PRK10517  407 AWLNSHyqtGLKNLLDTAVLEGVDEesARSLASRW---------------------------QKIDE----------IPF 449
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  707 SSALQRMDVVVTWPGAtQPEAYVKGSPELVASLCS-----PETVPSDFS------QVLQSYTAAGYRVVALAGKPLPiap 775
Cdd:PRK10517  450 DFERRRMSVVVAENTE-HHQLICKGALEEILNVCSqvrhnGEIVPLDDImlrrikRVTDTLNRQGLRVVAVATKYLP--- 525
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  776 slaAAQQLTRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAvtvARACGMVGAqEHLAVIHAT 855
Cdd:PRK10517  526 ---AREGDYQRADESDLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSELVA---AKVCHEVGL-DAGEVLIGS 598
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  856 HPEQgqpaaleflptessavMNGAKatgyptvpepqschlalsgstfavlrkhfpklLPKVLVQATVFARMAPEQKTELV 935
Cdd:PRK10517  599 DIET----------------LSDDE--------------------------------LANLAERTTLFARLTPMHKERIV 630
                         730       740       750
                  ....*....|....*....|....*....|....*
gi 568932020  936 CELQRLQYCVGMCGDGANDCGALKAADVGISLSQA 970
Cdd:PRK10517  631 TLLKREGHVVGFMGDGINDAPALRAADIGISVDGA 665
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
271-343 7.00e-04

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 39.49  E-value: 7.00e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568932020    271 TCDDVHCS-SSGLSLQDQATRKTIYGPNVISIPVK-SYLQLLADEALNPyygfqaFSIALWLADhyywyALCIFL 343
Cdd:smart00831   12 VLERLQTDlEKGLSSEEAARRLERYGPNELPPPKKtSPLLRFLRQFHNP------LIYILLAAA-----VLSALL 75
 
Name Accession Description Interval E-value
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
35-1150 0e+00

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 1282.31  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020    35 VRLSGYCGSPWRAIGYHAAVWMLAGIPWLLFRWKPLWGVRLRLKPCSLAHAETLVIEIKdkegssrqlftvqvQTEAVVQ 114
Cdd:TIGR01657    4 IGISAYKISPFKLIIYLVTLILTFGLVLLLLTWLPEWKVKLRYVPVSNEDAETVVIVDP--------------TPNSGSD 69
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   115 GSLELPPQAQAEDGRSQAAVGVTPEGTWQDTSELHRQEEAVSGQlgsrprlvllwasrshavwedwahgslcpsgslwsr 194
Cdd:TIGR01657   70 YIVELSNKSLSNDLQTENAVEGGEEPIYFDFRKQRFSYHEKELK------------------------------------ 113
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   195 rpvilsdrqaslshdaiplpsptlcvwmlharppptglssltqkqvlryyvlqgqryVWMETQQAFCQVSlldHGRTCDD 274
Cdd:TIGR01657  114 ---------------------------------------------------------IFSPLPYLFKEKS---FGVYSTC 133
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   275 VHcSSSGLSLQDQATRKTIYGPNVISIPVKSYLQLLADEALNPYYGFQAFSIALWLADHYYWYALCIFLISAISICLALY 354
Cdd:TIGR01657  134 AG-HSNGLTTGDIAQRKAKYGKNEIEIPVPSFLELLKEEVLHPFYVFQVFSVILWLLDEYYYYSLCIVFMSSTSISLSVY 212
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   355 KTRKQSLTLRDMVKLSVRVQVCRPGgEEEWVDSSELVPGDCLVLP-QEGGVMPCDAALVAGECVVNESSLTGESTPVLKT 433
Cdd:TIGR01657  213 QIRKQMQRLRDMVHKPQSVIVIRNG-KWVTIASDELVPGDIVSIPrPEEKTMPCDSVLLSGSCIVNESMLTGESVPVLKF 291
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   434 ALPEG----PKPYCPETHRRHTLFCGTLILQARAYVGPR-VLAVVTRTGFCTAKGGLVSSILHPRPISFKFYKHSMKFVA 508
Cdd:TIGR01657  292 PIPDNgdddEDLFLYETSKKHVLFGGTKILQIRPYPGDTgCLAIVVRTGFSTSKGQLVRSILYPKPRVFKFYKDSFKFIL 371
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   509 ALSVLALLGTVYSIIILYRNRVPVREIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLV 588
Cdd:TIGR01657  372 FLAVLALIGFIYTIIELIKDGRPLGKIILRSLDIITIVVPPALPAELSIGINNSLARLKKKGIFCTSPFRINFAGKIDVC 451
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   589 CFDKTGTLTEDGLDVMGVVPLKG-QVLLPLVPEPCHLPLGPLLRALATCHALSQLHDTPVGDPMDLKMVESTGWVLEEgp 667
Cdd:TIGR01657  452 CFDKTGTLTEDGLDLRGVQGLSGnQEFLKIVTEDSSLKPSITHKALATCHSLTKLEGKLVGDPLDKKMFEATGWTLEE-- 529
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   668 AAGSAPGSQVLVVMRpppggprqQEEPPVPVSVLCRFPFSSALQRMDVVVTWPGATQPEAYVKGSPELVASLCSPETVPS 747
Cdd:TIGR01657  530 DDESAEPTSILAVVR--------TDDPPQELSIIRRFQFSSALQRMSVIVSTNDERSPDAFVKGAPETIQSLCSPETVPS 601
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   748 DFSQVLQSYTAAGYRVVALAGKPLPiAPSLAAAQQLTRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTG 827
Cdd:TIGR01657  602 DYQEVLKSYTREGYRVLALAYKELP-KLTLQKAQDLSRDAVESNLTFLGFIVFENPLKPDTKEVIKELKRASIRTVMITG 680
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   828 DNLQTAVTVARACGMVGAQEHLAVIHATHPEQGQPAALEFLPTESSAVMNGAKATGYP----TVPEPQSC--HLALSGST 901
Cdd:TIGR01657  681 DNPLTAVHVARECGIVNPSNTLILAEAEPPESGKPNQIKFEVIDSIPFASTQVEIPYPlgqdSVEDLLASryHLAMSGKA 760
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   902 FAVLRKHFPKLLPKVLVQATVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSS 981
Cdd:TIGR01657  761 FAVLQAHSPELLLRLLSHTTVFARMAPDQKETLVELLQKLDYTVGMCGDGANDCGALKQADVGISLSEAEASVAAPFTSK 840
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   982 MASIECVPTVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALTLVR 1061
Cdd:TIGR01657  841 LASISCVPNVIREGRCALVTSFQMFKYMALYSLIQFYSVSILYLIGSNLGDGQFLTIDLLLIFPVALLMSRNKPLKKLSK 920
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  1062 ARPPGALLSVPVLGSLLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVPAPDNLPNYENTVVFSLSGFQYLILAAAVSKGA 1141
Cdd:TIGR01657  921 ERPPSNLFSVYILTSVLIQFVLHILSQVYLVFELHAQPWYKPENPVDLEKENFPNLLNTVLFFVSSFQYLITAIVNSKGP 1000

                   ....*....
gi 568932020  1142 PFRQPLYTN 1150
Cdd:TIGR01657 1001 PFREPIYKN 1009
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
285-1118 0e+00

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 1183.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  285 QDQATRKTIYGPNVISIPVKSYLQLLADEALNPYYGFQAFSIALWLADHYYWYALCIFLISAISICLALYKTRKQSLTLR 364
Cdd:cd07542     1 DEQSDRRLIYGPNEIDVPLKSILKLLFKEVLNPFYVFQLFSVILWSSDDYYYYAACIVIISVISIFLSLYETRKQSKRLR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  365 DMVKLSVRVQVCRPGgEEEWVDSSELVPGDCLVLPQEGGVMPCDAALVAGECVVNESSLTGESTPVLKTALPEG-----P 439
Cdd:cd07542    81 EMVHFTCPVRVIRDG-EWQTISSSELVPGDILVIPDNGTLLPCDAILLSGSCIVNESMLTGESVPVTKTPLPDEsndslW 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  440 KPYCPETHRRHTLFCGTLILQARAYVGPRVLAVVTRTGFCTAKGGLVSSILHPRPISFKFYKHSMKFVAALSVLALLGTV 519
Cdd:cd07542   160 SIYSIEDHSKHTLFCGTKVIQTRAYEGKPVLAVVVRTGFNTTKGQLVRSILYPKPVDFKFYRDSMKFILFLAIIALIGFI 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  520 YSIIILYRNRVPVREIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFDKTGTLTED 599
Cdd:cd07542   240 YTLIILILNGESLGEIIIRALDIITIVVPPALPAALTVGIIYAQSRLKKKGIFCISPQRINICGKINLVCFDKTGTLTED 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  600 GLDVMGVVPLKGQVLLPLVPEPC------HLPLGPLLRALATCHALSQLHDTPVGDPMDLKMVESTGWVLEegpaagsap 673
Cdd:cd07542   320 GLDLWGVRPVSGNNFGDLEVFSLdldldsSLPNGPLLRAMATCHSLTLIDGELVGDPLDLKMFEFTGWSLE--------- 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  674 gsqvlvvmrpppggprqqeeppvpvsVLCRFPFSSALQRMDVVVTWPGATQPEAYVKGSPELVASLCSPETVPSDFSQVL 753
Cdd:cd07542   391 --------------------------ILRQFPFSSALQRMSVIVKTPGDDSMMAFTKGAPEMIASLCKPETVPSNFQEVL 444
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  754 QSYTAAGYRVVALAGKPLPIAPSLaaAQQLTRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTA 833
Cdd:cd07542   445 NEYTKQGFRVIALAYKALESKTWL--LQKLSREEVESDLEFLGLIVMENRLKPETAPVINELNRANIRTVMVTGDNLLTA 522
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  834 VTVARACGMVGAQEHLAVIHATHPEQGQPAALEFlptessavmngakatgyptvpepqschlalsgstfavlrkhfpkll 913
Cdd:cd07542   523 ISVARECGMISPSKKVILIEAVKPEDDDSASLTW---------------------------------------------- 556
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  914 pKVLVQATVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPTVIR 993
Cdd:cd07542   557 -TLLLKGTVFARMSPDQKSELVEELQKLDYTVGMCGDGANDCGALKAADVGISLSEAEASVAAPFTSKVPDISCVPTVIK 635
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  994 EGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALTLVRARPPGALLSVPV 1073
Cdd:cd07542   636 EGRAALVTSFSCFKYMALYSLIQFISVLILYSINSNLGDFQFLFIDLVIITPIAVFMSRTGAYPKLSSKRPPASLVSPPV 715
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....*
gi 568932020 1074 LGSLLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVPAPDNLPNYE 1118
Cdd:cd07542   716 LVSLLGQIVLILLFQVIGFLIVRQQPWYIPPEPTVDKANTDNSNE 760
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
288-1101 0e+00

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 629.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  288 ATRKTIYGPNVISIPVKSYLQLLADEALNPYYGFQAFSIALWLADHYYWYALCIFLISAISICLALYKTRKQSLTLRDMV 367
Cdd:cd02082     3 DQLLAYYGKNEIEINVPSFLTLMWREFKKPFNFFQYFGVILWGIDEYVYYAITVVFMTTINSLSCIYIRGVMQKELKDAC 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  368 KLSVRVQVCRPGGEEEWVDSSELVPGDCLVLPQEGGVMPCDAALVAGECVVNESSLTGESTPVLKTALPEgPKP----YC 443
Cdd:cd02082    83 LNNTSVIVQRHGYQEITIASNMIVPGDIVLIKRREVTLPCDCVLLEGSCIVTEAMLTGESVPIGKCQIPT-DSHddvlFK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  444 PETHRRHTLFCGTLILQARAYVGPRVLAVVTRTGFCTAKGGLVSSILHPRPISFKFYKHSMKFVAALSVLALLGTVYSII 523
Cdd:cd02082   162 YESSKSHTLFQGTQVMQIIPPEDDILKAIVVRTGFGTSKGQLIRAILYPKPFNKKFQQQAVKFTLLLATLALIGFLYTLI 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  524 ILYRNRVPVREIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFDKTGTLTEDGLDV 603
Cdd:cd02082   242 RLLDIELPPLFIAFEFLDILTYSVPPGLPMLIAITNFVGLKRLKKNQILCQDPNRISQAGRIQTLCFDKTGTLTEDKLDL 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  604 MGvVPLKGQVLLpLVPEPCHLPLGPLL--RALATCHALSQLHDTPVGDPMDLKMVESTGWVLEEGPAAG---SAPGSQVL 678
Cdd:cd02082   322 IG-YQLKGQNQT-FDPIQCQDPNNISIehKLFAICHSLTKINGKLLGDPLDVKMAEASTWDLDYDHEAKqhySKSGTKRF 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  679 VVMRpppggprqqeeppvpvsvlcRFPFSSALQRMDVVVTWPGATQPE----AYVKGSPELVASLCSpeTVPSDFSQVLQ 754
Cdd:cd02082   400 YIIQ--------------------VFQFHSALQRMSVVAKEVDMITKDfkhyAFIKGAPEKIQSLFS--HVPSDEKAQLS 457
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  755 SYTAAGYRVVALAGKPLPiAPSLAAAQQLTRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAV 834
Cdd:cd02082   458 TLINEGYRVLALGYKELP-QSEIDAFLDLSREAQEANVQFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTAL 536
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  835 TVARACGMVGAQEHLAVIHATHPEQGQPAALEFlptessavmngakatgyptvpepqscHLALSGstfavlrkhfpkllp 914
Cdd:cd02082   537 KVAQELEIINRKNPTIIIHLLIPEIQKDNSTQW--------------------------ILIIHT--------------- 575
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  915 kvlvqaTVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQAEASVVSPFTSSMASIECVPTVIRE 994
Cdd:cd02082   576 ------NVFARTAPEQKQTIIRLLKESDYIVCMCGDGANDCGALKEADVGISLAEADASFASPFTSKSTSISCVKRVILE 649
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  995 GRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAVLmSRTGPALTLVRARPPGALLSVPVL 1074
Cdd:cd02082   650 GRVNLSTSVEIFKGYALVALIRYLSFLTLYYFYSSYSSSGQMDWQLLAAGYFLVY-LRLGCNTPLKKLEKDDNLFSIYNV 728
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|.
gi 568932020 1075 GSLLLQ--------VALVAGIQLGG------YFLVIAQPWF 1101
Cdd:cd02082   729 TSVLFGftlhilsiVGCVESLQASPiykevnSLDAENNFQF 769
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
286-1150 3.30e-143

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 452.61  E-value: 3.30e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  286 DQATRKTIYGPNVISIPVKSYLQLLADEALNPYYGFQAFSIALWLADHYYWYALcIFLISAISICLALYKTRKQSLT-LR 364
Cdd:cd07543     1 DIAAAKKKYGKNKFDIPVPTFSELFKEHAVAPFFVFQVFCVGLWCLDEYWYYSL-FTLFMLVAFEATLVFQRMKNLSeFR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  365 DMVKLSVRVQVCRPGgeeEWV--DSSELVPGDCLVL--PQEGGVMPCDAALVAGECVVNESSLTGESTPVLKTALPEGPK 440
Cdd:cd07543    80 TMGNKPYTIQVYRDG---KWVpiSSDELLPGDLVSIgrSAEDNLVPCDLLLLRGSCIVNEAMLTGESVPLMKEPIEDRDP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  441 P---YCPETHRRHTLFCGTLILQ--ARAYVGPR-----VLAVVTRTGFCTAKGGLVSSILHPRPISFKFYKHSMKFVAAL 510
Cdd:cd07543   157 EdvlDDDGDDKLHVLFGGTKVVQhtPPGKGGLKppdggCLAYVLRTGFETSQGKLLRTILFSTERVTANNLETFIFILFL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  511 SVLALLGTVYSIII---LYRNRVpvrEIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRL 587
Cdd:cd07543   237 LVFAIAAAAYVWIEgtkDGRSRY---KLFLECTLILTSVVPPELPMELSLAVNTSLIALAKLYIFCTEPFRIPFAGKVDI 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  588 VCFDKTGTLTEDGLDVMGVVPLK--GQVLLPLVPEPchlplGPLLRALATCHALSQLHD-TPVGDPMDLKMVESTGWVLE 664
Cdd:cd07543   314 CCFDKTGTLTSDDLVVEGVAGLNdgKEVIPVSSIEP-----VETILVLASCHSLVKLDDgKLVGDPLEKATLEAVDWTLT 388
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  665 EGPAA-GSAPGSQVLVVMRpppggprqqeeppvpvsvlcRFPFSSALQRMDVVVTW--PGATQPE--AYVKGSPELVASL 739
Cdd:cd07543   389 KDEKVfPRSKKTKGLKIIQ--------------------RFHFSSALKRMSVVASYkdPGSTDLKyiVAVKGAPETLKSM 448
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  740 CSpeTVPSDFSQVLQSYTAAGYRVVALAGKPLPIApSLAAAQQLTRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTG 819
Cdd:cd07543   449 LS--DVPADYDEVYKEYTRQGSRVLALGYKELGHL-TKQQARDYKREDVESDLTFAGFIVFSCPLKPDSKETIKELNNSS 525
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  820 IRTVMVTGDNLQTAVTVARACGMVgAQEHLAVIhathpeqgqpaalefLPTESSAVMNgakatgyptvpepqschlalsg 899
Cdd:cd07543   526 HRVVMITGDNPLTACHVAKELGIV-DKPVLILI---------------LSEEGKSNEW---------------------- 567
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  900 stfavlrkhfpKLLPKVlvqaTVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQ-AEASVVSPF 978
Cdd:cd07543   568 -----------KLIPHV----KVFARVAPKQKEFIITTLKELGYVTLMCGDGTNDVGALKHAHVGVALLKlGDASIAAPF 632
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  979 TSSMASIECVPTVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINTNLGDLQFLAIDLVIttTVAVLM-SRTGPAL 1057
Cdd:cd07543   633 TSKLSSVSCVCHIIKQGRCTLVTTLQMFKILALNCLISAYSLSVLYLDGVKFGDVQATISGLLL--AACFLFiSRSKPLE 710
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020 1058 TLVRARPPGALLSVPVLGSLLLQVAlvagIQLGgyFLVIAQPWFVPLNRTVPAPDN----LPNYENTVVFSLSGFQYLIL 1133
Cdd:cd07543   711 TLSKERPLPNIFNLYTILSVLLQFA----VHFV--SLVYITGEAKELEPPREEVDLekefEPSLVNSTVYILSMAQQVAT 784
                         890
                  ....*....|....*..
gi 568932020 1134 AAAVSKGAPFRQPLYTN 1150
Cdd:cd07543   785 FAVNYKGRPFRESLREN 801
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
340-1050 4.21e-136

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 425.19  E-value: 4.21e-136
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   340 CIFLISAISICLALY---KTRKQSLTLRDMVKLSVRVQVCRPGGEeeWVDSSELVPGDCLVLPqEGGVMPCDAALVAGEC 416
Cdd:TIGR01494    1 FILFLVLLFVLLEVKqklKAEDALRSLKDSLVNTATVLVLRNGWK--EISSKDLVPGDVVLVK-SGDTVPADGVLLSGSA 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   417 VVNESSLTGESTPVLKTALPEGPKPycpetHRRHTLFCGTLILQARAYVG---PRVLAVVTRTGFCTakgglvSSILHPR 493
Cdd:TIGR01494   78 FVDESSLTGESLPVLKTALPDGDAV-----FAGTINFGGTLIVKVTATGIlttVGKIAVVVYTGFST------KTPLQSK 146
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   494 PISFKFykhsMKFVAALSVLALLGTVYSIIILYRNRvPVREIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFC 573
Cdd:TIGR01494  147 ADKFEN----FIFILFLLLLALAVFLLLPIGGWDGN-SIYKAILRALAVLVIAIPCALPLAVSVALAVGDARMAKKGILV 221
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   574 IHPLRINLGGKLRLVCFDKTGTLTEDGLDVMGVVPLKGQVLLplvpepchLPLGPLLRALATCHalsqlhdtpVGDPMDL 653
Cdd:TIGR01494  222 KNLNALEELGKVDVICFDKTGTLTTNKMTLQKVIIIGGVEEA--------SLALALLAASLEYL---------SGHPLER 284
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   654 KMVESTGWVLEEgpaagsapgsqvlvvmrpppggprqqEEPPVPVSVLCRFPFSSALQRMDVVVTWPGATQpEAYVKGSP 733
Cdd:TIGR01494  285 AIVKSAEGVIKS--------------------------DEINVEYKILDVFPFSSVLKRMGVIVEGANGSD-LLFVKGAP 337
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   734 ELVASLCSPEtvpSDFSQVLQSYTAAGYRVVALAGKPLPiapslaaaqqltrdtveRELSLLGLLVMRNLLKPQTAPVIQ 813
Cdd:TIGR01494  338 EFVLERCNNE---NDYDEKVDEYARQGLRVLAFASKKLP-----------------DDLEFLGLLTFEDPLRPDAKETIE 397
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   814 TLRKTGIRTVMVTGDNLQTAVTVARACGMVgaqehlavihathpeqgqpaaleflptessavmngakatgyptvpepqsc 893
Cdd:TIGR01494  398 ALRKAGIKVVMLTGDNVLTAKAIAKELGID-------------------------------------------------- 427
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   894 hlalsgstfavlrkhfpkllpkvlvqatVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQ---A 970
Cdd:TIGR01494  428 ----------------------------VFARVKPEEKAAIVEALQEKGRTVAMTGDGVNDAPALKKADVGIAMGSgdvA 479
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   971 EASVVSPFTSSmaSIECVPTVIREGRCSLDTSFSVFKYMALYSLTQFISVLILYTINtnlgdlqflaidLVITTTVAVLM 1050
Cdd:TIGR01494  480 KAAADIVLLDD--DLSTIVEAVKEGRKTFSNIKKNIFWAIAYNLILIPLALLLIVII------------LLPPLLAALAL 545
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
266-1098 3.67e-77

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 273.52  E-value: 3.67e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  266 LDHGRTCDDVHCSSSGLSLQDQATRKTIYGPNVISIPVK-SYLQLLADEALNPyygfqaFSIALWLA-------DHYYwY 337
Cdd:COG0474    11 LSAEEVLAELGTSEEGLSSEEAARRLARYGPNELPEEKKrSLLRRFLEQFKNP------LILILLAAavisallGDWV-D 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  338 ALCIFLISAISICLALYKTRK--QSLT-LRDMVklSVRVQVCRpGGEEEWVDSSELVPGDCLVLpQEGGVMPCDAALV-A 413
Cdd:COG0474    84 AIVILAVVLLNAIIGFVQEYRaeKALEaLKKLL--APTARVLR-DGKWVEIPAEELVPGDIVLL-EAGDRVPADLRLLeA 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  414 GECVVNESSLTGESTPVLKTALPEGPKPycPETHRRHTLFCGTLILQARAyvgprvLAVVTRTGFCTAKGGLVSSI--LH 491
Cdd:COG0474   160 KDLQVDESALTGESVPVEKSADPLPEDA--PLGDRGNMVFMGTLVTSGRG------TAVVVATGMNTEFGKIAKLLqeAE 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  492 PRPISFKfyKHSMKFVAALSVLAL-LGTVYSIIILYRNRvPVREIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQG 570
Cdd:COG0474   232 EEKTPLQ--KQLDRLGKLLAIIALvLAALVFLIGLLRGG-PLLEALLFAVALAVAAIPEGLPAVVTITLALGAQRMAKRN 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  571 IfcihplrI--------NLGGkLRLVCFDKTGTLTEDGLDVMGVVPLKGQVLLPLVPEPchlPLGPLLRALATCHALSQL 642
Cdd:COG0474   309 A-------IvrrlpaveTLGS-VTVICTDKTGTLTQNKMTVERVYTGGGTYEVTGEFDP---ALEELLRAAALCSDAQLE 377
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  643 HDTPVGDPMDlkmvestGWVLEEGPAAGsapgsqvLVVMRPPPGGPRQQEeppvpvsvlcrFPFSSALQRMDVVVTWPGA 722
Cdd:COG0474   378 EETGLGDPTE-------GALLVAAAKAG-------LDVEELRKEYPRVDE-----------IPFDSERKRMSTVHEDPDG 432
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  723 tQPEAYVKGSPELVASLCS-----------PETVPSDFSQVLQSYTAAGYRVVALAGKPLPiapslaAAQQLTRDTVERE 791
Cdd:COG0474   433 -KRLLIVKGAPEVVLALCTrvltgggvvplTEEDRAEILEAVEELAAQGLRVLAVAYKELP------ADPELDSEDDESD 505
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  792 LSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTVARACGMVGAQEHlaVIHAthpeqgqpAALEflpte 871
Cdd:COG0474   506 LTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR--VLTG--------AELD----- 570
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  872 ssavmngakatgyptvpepqschlALSGSTFAvlrkhfpkllpKVLVQATVFARMAPEQKTELVCELQRLQYCVGMCGDG 951
Cdd:COG0474   571 ------------------------AMSDEELA-----------EAVEDVDVFARVSPEHKLRIVKALQANGHVVAMTGDG 615
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  952 ANDCGALKAADVGISLSQA------EAsvvspftSSM-------ASIEcvpTVIREGRcsldtsfSVF----KYmalysl 1014
Cdd:COG0474   616 VNDAPALKAADIGIAMGITgtdvakEA-------ADIvllddnfATIV---AAVEEGR-------RIYdnirKF------ 672
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020 1015 tqfisvlILYTINTNLGD------------------LQFLAIDLVITTTvavlmsrtgPALTL--------VRARPP--- 1065
Cdd:COG0474   673 -------IKYLLSSNFGEvlsvllasllglplpltpIQILWINLVTDGL---------PALALgfepvepdVMKRPPrwp 736
                         890       900       910
                  ....*....|....*....|....*....|....
gi 568932020 1066 -GALLSVPVLGSLLLQVALVAGIQLGGYFLVIAQ 1098
Cdd:COG0474   737 dEPILSRFLLLRILLLGLLIAIFTLLTFALALAR 770
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
281-996 5.74e-54

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 201.30  E-value: 5.74e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  281 GLSLQDQATRKTIYGPN-VISIPVKSYLQLLADEALNP----YYGFQAFSIALWLadhyYWYALCIFLISAISICLALYK 355
Cdd:cd02089     1 GLSEEEAERRLAKYGPNeLVEKKKRSPWKKFLEQFKDFmvivLLAAAVISGVLGE----YVDAIVIIAIVILNAVLGFVQ 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  356 TRK--QSL-TLRDMVKLSVRVqvcRPGGEEEWVDSSELVPGDCLVLpQEGGVMPCDAALV-AGECVVNESSLTGESTPVL 431
Cdd:cd02089    77 EYKaeKALaALKKMSAPTAKV---LRDGKKQEIPARELVPGDIVLL-EAGDYVPADGRLIeSASLRVEESSLTGESEPVE 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  432 KTALPEgPKPYCPETHRRHTLFCGTLILQARAyvgprvLAVVTRTGFCTAKG---GLVSSILHPR-PISFKFYKHSMKfv 507
Cdd:cd02089   153 KDADTL-LEEDVPLGDRKNMVFSGTLVTYGRG------RAVVTATGMNTEMGkiaTLLEETEEEKtPLQKRLDQLGKR-- 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  508 aaLSVLALLGTVYSIIILYRNRVPVREIVIRALDLVTVVVPPALPAAMT-VCTLYAQSRLRTQGIfcIHPLR-INLGGKL 585
Cdd:cd02089   224 --LAIAALIICALVFALGLLRGEDLLDMLLTAVSLAVAAIPEGLPAIVTiVLALGVQRMAKRNAI--IRKLPaVETLGSV 299
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  586 RLVCFDKTGTLTEDGLDVMGVVplkgqvllplvpepchlplgpllralatchalsqlhdtPVGDPMDLKMVEstgwvlee 665
Cdd:cd02089   300 SVICSDKTGTLTQNKMTVEKIY--------------------------------------TIGDPTETALIR-------- 333
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  666 gpAAGSAPGSQVLVVMRPppggPRQQEeppvpvsvlcrFPFSSALQRMDVVVTWPGATQpeAYVKGSPELVASLCS---- 741
Cdd:cd02089   334 --AARKAGLDKEELEKKY----PRIAE-----------IPFDSERKLMTTVHKDAGKYI--VFTKGAPDVLLPRCTyiyi 394
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  742 -----PETvPSDFSQ---VLQSYTAAGYRVVALAGKPLPIAPslaaaqQLTRDTVERELSLLGLLVMRNLLKPQTAPVIQ 813
Cdd:cd02089   395 ngqvrPLT-EEDRAKilaVNEEFSEEALRVLAVAYKPLDEDP------TESSEDLENDLIFLGLVGMIDPPRPEVKDAVA 467
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  814 TLRKTGIRTVMVTGDNLQTAVTVARACGMVgaqehlavihathpEQGqpaaleflptessavmngakatgyptvpepqsc 893
Cdd:cd02089   468 ECKKAGIKTVMITGDHKLTARAIAKELGIL--------------EDG--------------------------------- 500
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  894 HLALSGSTfavLRKHFPKLLPKVLVQATVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQAeAS 973
Cdd:cd02089   501 DKALTGEE---LDKMSDEELEKKVEQISVYARVSPEHKLRIVKALQRKGKIVAMTGDGVNDAPALKAADIGVAMGIT-GT 576
                         730       740       750
                  ....*....|....*....|....*....|
gi 568932020  974 VVSPFTSSM-------ASIEcvpTVIREGR 996
Cdd:cd02089   577 DVAKEAADMiltddnfATIV---AAVEEGR 603
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
281-1093 2.64e-50

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 192.48  E-value: 2.64e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  281 GLSLQDQATRKTIYGPNVISI-PVKSYLQLLADEALNPYYGFQAFSIALWLADHYYWYALCIFLISAISICLALYKTRK- 358
Cdd:cd02080     1 GLTSEEAAERLERYGPNRLPEkKTKSPLLRFLRQFNNPLIYILLAAAVVTAFLGHWVDAIVIFGVVLINAIIGYIQEGKa 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  359 -QSL-TLRDMvkLSVRVQVCRPGGEEEwVDSSELVPGDcLVLPQEGGVMPCDAALV-AGECVVNESSLTGESTPVLKT-- 433
Cdd:cd02080    81 eKALaAIKNM--LSPEATVLRDGKKLT-IDAEELVPGD-IVLLEAGDKVPADLRLIeARNLQIDESALTGESVPVEKQeg 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  434 ALPEGpkpyCPETHRRHTLFCGTLILQARAyvgprvLAVVTRTGFCTAKGGLVSSILHPRPISFKFYKHSMKFVAALSVL 513
Cdd:cd02080   157 PLEED----TPLGDRKNMAYSGTLVTAGSA------TGVVVATGADTEIGRINQLLAEVEQLATPLTRQIAKFSKALLIV 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  514 ALLGTVYSIII-LYRNRVPVREIVIRALDLVTVVVPPALPAAMTVCTLYAQSRL-RTQGIFCIHPLRINLGGkLRLVCFD 591
Cdd:cd02080   227 ILVLAALTFVFgLLRGDYSLVELFMAVVALAVAAIPEGLPAVITITLAIGVQRMaKRNAIIRRLPAVETLGS-VTVICSD 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  592 KTGTLTEDGLDVMGVVPLkgqvllplvpepchlplgpllralatCHAlSQLHDtpvgdpmdlkmvESTGWVLEEGPAAGS 671
Cdd:cd02080   306 KTGTLTRNEMTVQAIVTL--------------------------CND-AQLHQ------------EDGHWKITGDPTEGA 346
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  672 apgsqvLVVMRPPPGGPRQQEEPPVPVSVLcrFPFSSALQRMDVVVtwPGATQPEAYVKGSPELVASLCSPETVPSDFS- 750
Cdd:cd02080   347 ------LLVLAAKAGLDPDRLASSYPRVDK--IPFDSAYRYMATLH--RDDGQRVIYVKGAPERLLDMCDQELLDGGVSp 416
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  751 -------QVLQSYTAAGYRVVALAGKPLPiapslAAAQQLTRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTV 823
Cdd:cd02080   417 ldrayweAEAEDLAKQGLRVLAFAYREVD-----SEVEEIDHADLEGGLTFLGLQGMIDPPRPEAIAAVAECQSAGIRVK 491
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  824 MVTGDNLQTAVTVARACGMVgaqehlavihathpeqgqpaaleflptessavmNGAKatgyptvpepqschlALSGSTFA 903
Cdd:cd02080   492 MITGDHAETARAIGAQLGLG---------------------------------DGKK---------------VLTGAELD 523
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  904 VLRKhfpKLLPKVLVQATVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQA------EASVVSP 977
Cdd:cd02080   524 ALDD---EELAEAVDEVDVFARTSPEHKLRLVRALQARGEVVAMTGDGVNDAPALKQADIGIAMGIKgtevakEAADMVL 600
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  978 FTSSMASIEcvpTVIREGRCSLDtsfsvfkymalySLTQFisvlILYTINTNLGD------------------LQFLAID 1039
Cdd:cd02080   601 ADDNFATIA---AAVEEGRRVYD------------NLKKF----ILFTLPTNLGEglviivailfgvtlpltpVQILWIN 661
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568932020 1040 LVITTTVAvLMSRTGPALTLVRARPPGAlLSVPVL-GSLLLQVALVAGIQLGGYF 1093
Cdd:cd02080   662 MVTAITLG-LALAFEPAEPGIMKRPPRD-PSEPLLsRELIWRILLVSLLMLGGAF 714
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
363-1048 8.34e-45

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 172.99  E-value: 8.34e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  363 LRDMVKLSVRVqVCRPGGEEEWVDSSELVPGDCLVLpQEGGVMPCDAALVAGECV-VNESSLTGESTPVLKTAlpeGPKP 441
Cdd:cd07539    88 LLAQQQQPARV-VRAPAGRTQTVPAESLVPGDVIEL-RAGEVVPADARLLEADDLeVDESALTGESLPVDKQV---APTP 162
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  442 YCPETHRRHTLFCGTLIlqarayVGPRVLAVVTRTGFCTAKG---GLVSSILHPRPISFKFYKHSMKFVAAlsVLALLGT 518
Cdd:cd07539   163 GAPLADRACMLYEGTTV------VSGQGRAVVVATGPHTEAGraqSLVAPVETATGVQAQLRELTSQLLPL--SLGGGAA 234
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  519 VYSIIILyrNRVPVREIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFDKTGTLTE 598
Cdd:cd07539   235 VTGLGLL--RGAPLRQAVADGVSLAVAAVPEGLPLVATLAQLAAARRLSRRGVLVRSPRTVEALGRVDTICFDKTGTLTE 312
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  599 DGLdvmgvvplkgqvllplvpepchlplgpllralatchALSQLHDtpvgdpmdlkmvestgwvleegpaagsapgsqvl 678
Cdd:cd07539   313 NRL------------------------------------RVVQVRP---------------------------------- 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  679 vvmrpppggprqqeeppvpvsVLCRFPFSSALQRMDVVVTwPGATQPEAYVKGSPELVASLCS-----------PETVPS 747
Cdd:cd07539   323 ---------------------PLAELPFESSRGYAAAIGR-TGGGIPLLAVKGAPEVVLPRCDrrmtggqvvplTEADRQ 380
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  748 DFSQVLQSYTAAGYRVVALAGKplpiapSLAAAQQLTRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTG 827
Cdd:cd07539   381 AIEEVNELLAGQGLRVLAVAYR------TLDAGTTHAVEAVVDDLELLGLLGLADTARPGAAALIAALHDAGIDVVMITG 454
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  828 DNLQTAVTVARACGMvgaQEHLAVihathpeqgqpaaleflptessavmngakatgyptvpepqschlaLSGSTFAVLRk 907
Cdd:cd07539   455 DHPITARAIAKELGL---PRDAEV---------------------------------------------VTGAELDALD- 485
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  908 hfPKLLPKVLVQATVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLS---QAEASVVSPFTSSMAS 984
Cdd:cd07539   486 --EEALTGLVADIDVFARVSPEQKLQIVQALQAAGRVVAMTGDGANDAAAIRAADVGIGVGargSDAAREAADLVLTDDD 563
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568932020  985 IECVPTVIREGRcsldtsfsvfkymalySLTQFISVLILYTINTNLGDLQFLAIDLVITTTVAV 1048
Cdd:cd07539   564 LETLLDAVVEGR----------------TMWQNVRDAVHVLLGGNLGEVMFTLIGTAIGGGAPL 611
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
281-970 1.98e-44

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 173.59  E-value: 1.98e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  281 GLSLQDQATRKTIYGPNVISIPVK-SYLQLLADEALNPyygfqaFSIALWLAD-----HYYWY---------ALCIFLIS 345
Cdd:cd02077     1 GLTNEEAEERLEKYGPNEISHEKFpSWFKLLLKAFINP------FNIVLLVLAlvsffTDVLLapgefdlvgALIILLMV 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  346 AISICLAL---YKTRKQSLTLRDMVKlsVRVQVCRPGGEEEWVDSSELVPGDCLVLpQEGGVMPCDAALV-AGECVVNES 421
Cdd:cd02077    75 LISGLLDFiqeIRSLKAAEKLKKMVK--NTATVIRDGSKYMEIPIDELVPGDIVYL-SAGDMIPADVRIIqSKDLFVSQS 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  422 SLTGESTPVLKTALPEGPKPYCPeTHRRHTLFCGTLILQARAyvgprvLAVVTRTGFCTAKGGLVSSIL-HPRPISF--- 497
Cdd:cd02077   152 SLTGESEPVEKHATAKKTKDESI-LELENICFMGTNVVSGSA------LAVVIATGNDTYFGSIAKSITeKRPETSFdkg 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  498 --KFYKHSMKFvaalsVLALLGTVYSIIILYRNrvPVREIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIF--- 572
Cdd:cd02077   225 inKVSKLLIRF-----MLVMVPVVFLINGLTKG--DWLEALLFALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVIvkn 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  573 --CIHplriNLGGkLRLVCFDKTGTLTEDGLDVMGVVPLKGQVllplvpepchlplGPLLRALAtchALSQLHDTPVGDP 650
Cdd:cd02077   298 lnAIQ----NFGA-MDILCTDKTGTLTQDKIVLERHLDVNGKE-------------SERVLRLA---YLNSYFQTGLKNL 356
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  651 MDLKMVESTgwvleegpaagsapgsqvlvvmrpppgGPRQQEEPPVPVSVLCRFPFSSALQRMDVVVTWPGATQpEAYVK 730
Cdd:cd02077   357 LDKAIIDHA---------------------------EEANANGLIQDYTKIDEIPFDFERRRMSVVVKDNDGKH-LLITK 408
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  731 GSPELVASLCS-----PETVPSDFS------QVLQSYTAAGYRVVALAGKPLPiapslAAAQQLTRDtVERELSLLGLLV 799
Cdd:cd02077   409 GAVEEILNVCThvevnGEVVPLTDTlrekilAQVEELNREGLRVLAIAYKKLP-----APEGEYSVK-DEKELILIGFLA 482
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  800 MRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLqtaVTVARACGMVGaqehlavihathpeqgqpaalefLPTESSavmnga 879
Cdd:cd02077   483 FLDPPKESAAQAIKALKKNGVNVKILTGDNE---IVTKAICKQVG-----------------------LDINRV------ 530
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  880 katgyptvpepqschlaLSGSTFAVLRKhfpKLLPKVLVQATVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALK 959
Cdd:cd02077   531 -----------------LTGSEIEALSD---EELAKIVEETNIFAKLSPLQKARIIQALKKNGHVVGFMGDGINDAPALR 590
                         730
                  ....*....|.
gi 568932020  960 AADVGISLSQA 970
Cdd:cd02077   591 QADVGISVDSA 601
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
703-1050 1.88e-43

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 161.08  E-value: 1.88e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  703 RFPFSSALQRMDVVVTWPGatQPEAYVKGSPELVASLCS---PETVPSDFSQVLQSYTAAGYRVVALAGKPLPIAPSlaa 779
Cdd:cd01431    24 EIPFNSTRKRMSVVVRLPG--RYRAIVKGAPETILSRCShalTEEDRNKIEKAQEESAREGLRVLALAYREFDPETS--- 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  780 aqqltRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTVARACGMVGAQEHLAVIHATHPEQ 859
Cdd:cd01431    99 -----KEAVELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNPLTAIAIAREIGIDTKASGVILGEEADEMS 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  860 GQpaaleflptessavmngakatgyptvpepqschlalsgstfavlrkhfpkLLPKVLVQATVFARMAPEQKTELVCELQ 939
Cdd:cd01431   174 EE--------------------------------------------------ELLDLIAKVAVFARVTPEQKLRIVKALQ 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  940 RLQYCVGMCGDGANDCGALKAADVGISLSQAeASVVSPFTSSMASIE----CVPTVIREGRCSLDTsfsVFKYMaLYSLT 1015
Cdd:cd01431   204 ARGEVVAMTGDGVNDAPALKQADVGIAMGST-GTDVAKEAADIVLLDdnfaTIVEAVEEGRAIYDN---IKKNI-TYLLA 278
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 568932020 1016 QFISVLILYTINTNLGD------LQFLAIDLVITTTVAVLM 1050
Cdd:cd01431   279 NNVAEVFAIALALFLGGplpllaFQILWINLVTDLIPALAL 319
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
288-973 1.35e-41

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 164.30  E-value: 1.35e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  288 ATRKTIYGPNVISIPV-KSYLQLLAdEALNPYY-------GFQAFSIALWLAD-----HYYWYA-----LCIFLISAISi 349
Cdd:cd02081     2 EHRREVYGKNEIPPKPpKSFLQLVW-EALQDPTliilliaAIVSLGLGFYTPFgegegKTGWIEgvailVAVILVVLVT- 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  350 clAL--YKTRKQSLTLRDMVKlSVRVQVCRpGGEEEWVDSSELVPGDCLVLpQEGGVMPCDAALVAG-ECVVNESSLTGE 426
Cdd:cd02081    80 --AGndYQKEKQFRKLNSKKE-DQKVTVIR-DGEVIQISVFDIVVGDIVQL-KYGDLIPADGLLIEGnDLKIDESSLTGE 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  427 STPVLKTALPEGPKPYcpethrrhtLFCGTLILQARAYVgpRVLAVVTRTgfCTAK-------GGLVSSILHPR--PISF 497
Cdd:cd02081   155 SDPIKKTPDNQIPDPF---------LLSGTKVLEGSGKM--LVTAVGVNS--QTGKimtllraENEEKTPLQEKltKLAV 221
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  498 KFYKHSMkFVAALSVLALlgTVYSIIILYRNRVPVR---------EIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRT 568
Cdd:cd02081   222 QIGKVGL-IVAALTFIVL--IIRFIIDGFVNDGKSFsaedlqefvNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMK 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  569 QGifcihplriNLGGKLR---------LVCFDKTGTLTEDgldVMGVVplkgqvllplvpepchlplgpllralatchal 639
Cdd:cd02081   299 DN---------NLVRHLDacetmgnatAICSDKTGTLTQN---RMTVV-------------------------------- 334
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  640 sqlhDTPVGDPMDLKMVestGWVLEEGpaagsapGSQVLVVMRPppggprqqEEPpvpvsVLCRFPFSSALQRMDVVVTW 719
Cdd:cd02081   335 ----QGYIGNKTECALL---GFVLELG-------GDYRYREKRP--------EEK-----VLKVYPFNSARKRMSTVVRL 387
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  720 PGaTQPEAYVKGSPELVASLCS------------PETVPSDFSQVLQSYTAAGYRVVALAGKPLPIAPSLAAAQQLT-RD 786
Cdd:cd02081   388 KD-GGYRLYVKGASEIVLKKCSyilnsdgevvflTSEKKEEIKRVIEPMASDSLRTIGLAYRDFSPDEEPTAERDWDdEE 466
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  787 TVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTVARACGMVgaqehlavihathpeqgqpaale 866
Cdd:cd02081   467 DIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNINTARAIARECGIL----------------------- 523
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  867 flptessavmngakatgyptvpEPQSCHLALSGSTF-----AVLRKHFPKLLPKVLVQATVFARMAPEQKTELVCELQRL 941
Cdd:cd02081   524 ----------------------TEGEDGLVLEGKEFrelidEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS 581
                         730       740       750
                  ....*....|....*....|....*....|....*...
gi 568932020  942 QYCVGMCGDGANDCGALKAADVGISLSQA------EAS 973
Cdd:cd02081   582 GEVVAVTGDGTNDAPALKKADVGFAMGIAgtevakEAS 619
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
281-1123 3.51e-38

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 155.32  E-value: 3.51e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   281 GLSLQ--DQATRKTIYGPNVIS-IPVKSYLQL----LADEALNPYYGFQAFSIALWLADHYY----------WY------ 337
Cdd:TIGR01517   59 GVRLSssTLERREKVYGKNELPeKPPKSFLQIvwaaLSDQTLILLSVAAVVSLVLGLYVPSVgedkadtetgWIegvail 138
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   338 --ALCIFLISAISiclalykTRKQSLTLRDMVKLS--VRVQVCRpGGEEEWVDSSELVPGDCLVLpQEGGVMPCDAALVA 413
Cdd:TIGR01517  139 vsVILVVLVTAVN-------DYKKELQFRQLNREKsaQKIAVIR-GGQEQQISIHDIVVGDIVSL-STGDVVPADGVFIS 209
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   414 G-ECVVNESSLTGESTPVlKTALPEGPkpycpethrrhTLFCGTLILQARAYVgprvlaVVTRTGFCTAKGGLVSSILHP 492
Cdd:TIGR01517  210 GlSLEIDESSITGESDPI-KKGPVQDP-----------FLLSGTVVNEGSGRM------LVTAVGVNSFGGKLMMELRQA 271
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   493 RPISFKFYKHSMKFVAALSVLALLGTVYSIIIL------YRNRVPVR------------EIVIRALDLVTVVVPPALPAA 554
Cdd:TIGR01517  272 GEEETPLQEKLSELAGLIGKFGMGSAVLLFLVLslryvfRIIRGDGRfedteedaqtflDHFIIAVTIVVVAVPEGLPLA 351
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   555 MTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFDKTGTLTEDGLDVMGVVPlkGQVLLPLVPEPCHLPLGPLLRALA 634
Cdd:TIGR01517  352 VTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGYI--GEQRFNVRDEIVLRNLPAAVRNIL 429
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   635 TcHALSQLHDTPVGdpmdlkmVESTGWVLEEGPAAGSAPGSQVLVVMRP--PPGGPRQQEEppvpvsVLCRFPFSSALQR 712
Cdd:TIGR01517  430 V-EGISLNSSSEEV-------VDRGGKRAFIGSKTECALLDFGLLLLLQsrDVQEVRAEEK------VVKIYPFNSERKF 495
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   713 MDVVVTWPGATQpEAYVKGSPELVASLCSP------ETVP------SDFSQVLQSYTAAGYRVVALAGKplpiapSLAAA 780
Cdd:TIGR01517  496 MSVVVKHSGGKY-REFRKGASEIVLKPCRKrldsngEATPiseddkDRCADVIEPLASDALRTICLAYR------DFAPE 568
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   781 QQLTRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTVARACGMVGAQEhlavihathpeqg 860
Cdd:TIGR01517  569 EFPRKDYPNKGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG------------- 635
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   861 qpaaleflptessavmngakatgyptvpepqschLALSGSTFAVLRKH-FPKLLPKVlvqaTVFARMAPEQKTELVCELQ 939
Cdd:TIGR01517  636 ----------------------------------LAMEGKEFRSLVYEeMDPILPKL----RVLARSSPLDKQLLVLMLK 677
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   940 RLQYCVGMCGDGANDCGALKAADVGISLSQA------EASVVSPFTSSMASIEcvpTVIREGRCSLDtsfSVFKYMALyS 1013
Cdd:TIGR01517  678 DMGEVVAVTGDGTNDAPALKLADVGFSMGISgtevakEASDIILLDDNFASIV---RAVKWGRNVYD---NIRKFLQF-Q 750
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  1014 LT--------QFISVLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALTLVRARPPG---ALLSVPVLGSLLLQva 1082
Cdd:TIGR01517  751 LTvnvvavilTFVGSCISSSHTSPLTAVQLLWVNLIMDTLAALALATEPPTEALLDRKPIGrnaPLISRSMWKNILGQ-- 828
                          890       900       910       920
                   ....*....|....*....|....*....|....*....|..
gi 568932020  1083 lvAGIQLGGYFLVI-AQPWFVPLNRTVPAPDNLPNYENTVVF 1123
Cdd:TIGR01517  829 --AGYQLVVTFILLfAGGSIFDVSGPDEITSHQQGELNTIVF 868
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
281-1026 1.39e-36

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 149.30  E-value: 1.39e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  281 GLSLQDQATRKTIYGPNVISIPVKSYLQLLADEALNPyygfqaFSIALWLAdhyywYALCIFL---ISAISICLAL---- 353
Cdd:cd02076     1 GLTSEEAAKRLKEYGPNELPEKKENPILKFLSFFWGP------IPWMLEAA-----AILAAALgdwVDFAIILLLLlina 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  354 ----YKTRKQSLTLRD-MVKLSVRVQVCRPGgeeEWV--DSSELVPGDcLVLPQEGGVMPCDAALVAGECV-VNESSLTG 425
Cdd:cd02076    70 gigfIEERQAGNAVAAlKKSLAPKARVLRDG---QWQeiDAKELVPGD-IVSLKIGDIVPADARLLTGDALqVDQSALTG 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  426 ESTPVLKtalpegpkpycpetHRRHTLFCGTLILQARayvgprVLAVVTRTGFCTAKGGLVSSILHPRPISfKFYKHSMK 505
Cdd:cd02076   146 ESLPVTK--------------HPGDEAYSGSIVKQGE------MLAVVTATGSNTFFGKTAALVASAEEQG-HLQKVLNK 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  506 FVAALSVLALLGTVYSIIILYRNRVPVREIVIRALDLVTVVVPPALPAAMTVcTLYAQSR-LRTQGIFCIHPLRINLGGK 584
Cdd:cd02076   205 IGNFLILLALILVLIIVIVALYRHDPFLEILQFVLVLLIASIPVAMPAVLTV-TMAVGALeLAKKKAIVSRLSAIEELAG 283
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  585 LRLVCFDKTGTLTEDGLDVMGVVPL----KGQVLlplvpepchlplgpLLRALATchalsqlhDTPVGDPMDLKMVESTG 660
Cdd:cd02076   284 VDILCSDKTGTLTLNKLSLDEPYSLegdgKDELL--------------LLAALAS--------DTENPDAIDTAILNALD 341
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  661 wvleegpaagsapgsqvlvvmRPPPGGPRQQEEPPVpvsvlcrfPFSSALQRMDVVVTWPGATQpEAYVKGSPELVASLC 740
Cdd:cd02076   342 ---------------------DYKPDLAGYKQLKFT--------PFDPVDKRTEATVEDPDGER-FKVTKGAPQVILELV 391
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  741 -SPETVPSDFSQVLQSYTAAGYRVVALAgkplpiapslaaaqqltRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTG 819
Cdd:cd02076   392 gNDEAIRQAVEEKIDELASRGYRSLGVA-----------------RKEDGGRWELLGLLPLFDPPRPDSKATIARAKELG 454
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  820 IRTVMVTGDNLQTAVTVARACGMvgaqehlavihathpeqgqpaaleflptessavmnGAKATGYPTVPEPQSCHLALSG 899
Cdd:cd02076   455 VRVKMITGDQLAIAKETARQLGM-----------------------------------GTNILSAERLKLGGGGGGMPGS 499
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  900 StfavlrkhfpklLPKVLVQATVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQAE------AS 973
Cdd:cd02076   500 E------------LIEFIEDADGFAEVFPEHKYRIVEALQQRGHLVGMTGDGVNDAPALKKADVGIAVSGATdaaraaAD 567
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568932020  974 VVspFTSSMASiecvpTVIRegrcSLDTSFSVFKYM---ALYSLTQFISVLILYTI 1026
Cdd:cd02076   568 IV--LTAPGLS-----VIID----AIKTSRQIFQRMksyVIYRIAETLRILVFFTL 612
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
368-996 6.73e-36

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 145.89  E-value: 6.73e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  368 KLSV----RVQVCRPGGEEEwVDSSELVPGDCLVLpQEGGVMPCDAALVAGECV-VNESSLTGESTPVLKTAlpeGPKpy 442
Cdd:cd02609    85 KLSIlnapKVTVIRDGQEVK-IPPEELVLDDILIL-KPGEQIPADGEVVEGGGLeVDESLLTGESDLIPKKA---GDK-- 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  443 cpethrrhtLFCGTLILQARAYvgprvlAVVTRTGFCTAKGGLVSSILHPRPISFKFYKHSMKFVAALSVLAL-LGTVYS 521
Cdd:cd02609   158 ---------LLSGSFVVSGAAY------ARVTAVGAESYAAKLTLEAKKHKLINSELLNSINKILKFTSFIIIpLGLLLF 222
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  522 IIILYRNRVPVREIVIRALDLVTVVVPPAL----PAAMTVCTL-YAQSRLRTQGIFCIHPL-RINLggklrlVCFDKTGT 595
Cdd:cd02609   223 VEALFRRGGGWRQAVVSTVAALLGMIPEGLvlltSVALAVGAIrLAKKKVLVQELYSIETLaRVDV------LCLDKTGT 296
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  596 LTEDGLDVMGVVPLKGQVLlPLVPEpchlplgpllRALATCHALSQLHDTpvgdpmdlkmvestgwvleegpaagsapgS 675
Cdd:cd02609   297 ITEGKMKVERVEPLDEANE-AEAAA----------ALAAFVAASEDNNAT-----------------------------M 336
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  676 QVLvvmrpppggpRQQEEPPVPVSVLCRFPFSSAlqrmdvvVTWPGATQP--EAYVKGSPELVASlcspeTVPSDFSQVL 753
Cdd:cd02609   337 QAI----------RAAFFGNNRFEVTSIIPFSSA-------RKWSAVEFRdgGTWVLGAPEVLLG-----DLPSEVLSRV 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  754 QSYTAAGYRVVALAgkplpiapslAAAQQLTRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTA 833
Cdd:cd02609   395 NELAAQGYRVLLLA----------RSAGALTHEQLPVGLEPLALILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTV 464
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  834 VTVARACGMVGAQEhlaVIHATHPEqgqpaaleflptessavmngakatgypTVPEpqschlalsgstfavlrkhfpklL 913
Cdd:cd02609   465 SAIAKRAGLEGAES---YIDASTLT---------------------------TDEE-----------------------L 491
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  914 PKVLVQATVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQAeasvvSPFTSSMASI-------E 986
Cdd:cd02609   492 AEAVENYTVFGRVTPEQKRQLVQALQALGHTVAMTGDGVNDVLALKEADCSIAMASG-----SDATRQVAQVvlldsdfS 566
                         650
                  ....*....|
gi 568932020  987 CVPTVIREGR 996
Cdd:cd02609   567 ALPDVVFEGR 576
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
281-996 2.03e-35

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 146.45  E-value: 2.03e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  281 GLSLQDQATRKTIYGPNvisipvksylQLLADEALNPYygfqafSIALwladHYYWYALCIFLISAISICLAL------- 353
Cdd:cd02086     1 GLTNDEAERRLKEYGEN----------ELEGDTGVSAW------KILL----RQVANAMTLVLIIAMALSFAVkdwiegg 60
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  354 -----------------YKTRKQSLTLRDMVklSVRVQVCRpGGEEEWVDSSELVPGDCLVLpQEGGVMPCDAALVAgec 416
Cdd:cd02086    61 viaavialnvivgfiqeYKAEKTMDSLRNLS--SPNAHVIR-SGKTETISSKDVVPGDIVLL-KVGDTVPADLRLIE--- 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  417 VVN----ESSLTGESTPVLKTALPE-GPKPYCPETHRRHTLFCGTLILQARAyvgprvLAVVTRTGFCTAKGGLVSSI-- 489
Cdd:cd02086   134 TKNfetdEALLTGESLPVIKDAELVfGKEEDVSVGDRLNLAYSSSTVTKGRA------KGIVVATGMNTEIGKIAKALrg 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  490 ----LHPRPISFKFY-------KHSMKFVAA---------LSVLALL----GTVYSIIILYRNRVPVR-EIVIRALDLVT 544
Cdd:cd02086   208 kgglISRDRVKSWLYgtlivtwDAVGRFLGTnvgtplqrkLSKLAYLlffiAVILAIIVFAVNKFDVDnEVIIYAIALAI 287
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  545 VVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFDKTGTLTEdgldvmgvvplkGQVLLPLVPEPCHL 624
Cdd:cd02086   288 SMIPESLVAVLTITMAVGAKRMVKRNVIVRKLDALEALGAVTDICSDKTGTLTQ------------GKMVVRQVWIPAAL 355
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  625 PlgpllrALATCHALSQLHD-TPVGDPMDLKM-VESTGWVLeegpaagsapGSQVLVVmrppPGGPRQQEeppvpvsvLC 702
Cdd:cd02086   356 C------NIATVFKDEETDCwKAHGDPTEIALqVFATKFDM----------GKNALTK----GGSAQFQH--------VA 407
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  703 RFPFSSALQRMDVVVTWPGATQPEAYVKGSPELVASLCS---------PETVPSDFSQVLQSYTAA--GYRVVALAGKPL 771
Cdd:cd02086   408 EFPFDSTVKRMSVVYYNNQAGDYYAYMKGAVERVLECCSsmygkdgiiPLDDEFRKTIIKNVESLAsqGLRVLAFASRSF 487
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  772 P---IAPSLAAAQQLTRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTVARACGMVgaqeh 848
Cdd:cd02086   488 TkaqFNDDQLKNITLSRADAESDLTFLGLVGIYDPPRNESAGAVEKCHQAGITVHMLTGDHPGTAKAIAREVGIL----- 562
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  849 lavihatHPEQGQPAAleflPTESSAVMNGAKATGyptvpepqschlaLSGSTFAVLrkhfpKLLPKVLvqatvfARMAP 928
Cdd:cd02086   563 -------PPNSYHYSQ----EIMDSMVMTASQFDG-------------LSDEEVDAL-----PVLPLVI------ARCSP 607
                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568932020  929 EQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQaEASVVSPFTSSM-------ASIecvPTVIREGR 996
Cdd:cd02086   608 QTKVRMIEALHRRKKFCAMTGDGVNDSPSLKMADVGIAMGL-NGSDVAKDASDIvltddnfASI---VNAIEEGR 678
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
281-967 7.72e-34

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 139.50  E-value: 7.72e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  281 GLSLQDQATRKTIYGPNVISIPVK-SYLQLLADEALNPYYG--FQAFSIALWLADHYYWYALCIFLISAISICLAL-YKT 356
Cdd:cd07538     1 GLTEAEARRRLESGGKNELPQPKKrTLLASILDVLREPMFLllLAAALIYFVLGDPREGLILLIFVVVIIAIEVVQeWRT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  357 RKQSLTLRDMVklSVRVQVCRpGGEEEWVDSSELVPGDCLVLpQEGGVMPCDAALVAGECV-VNESSLTGESTPVLKTal 435
Cdd:cd07538    81 ERALEALKNLS--SPRATVIR-DGRERRIPSRELVPGDLLIL-GEGERIPADGRLLENDDLgVDESTLTGESVPVWKR-- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  436 PEGPKPYCPETHRRHTLFCGTLILQARAYVgpRVLAVVTRTGFCTAKGGLVSSILHPRPISfkfyKHSMKFVAALSVLAL 515
Cdd:cd07538   155 IDGKAMSAPGGWDKNFCYAGTLVVRGRGVA--KVEATGSRTELGKIGKSLAEMDDEPTPLQ----KQTGRLVKLCALAAL 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  516 LGTVYSIIILYRNRVPVREIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFDKTGT 595
Cdd:cd07538   229 VFCALIVAVYGVTRGDWIQAILAGITLAMAMIPEEFPVILTVFMAMGAWRLAKKNVLVRRAAAVETLGSITVLCVDKTGT 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  596 LTEDGldvMGVVPLkgqvllplvpepchlplgpllralatchalsqlhdtpvgdpmdlkmvestgwvleegpaagsapgs 675
Cdd:cd07538   309 LTKNQ---MEVVEL------------------------------------------------------------------ 319
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  676 qvlvvmrpppggprqqeeppvpVSVLCRFPFSSALQRMDVVvtWPGATQPEAYVKGSPELVASLCSPETVPSDfSQVLQS 755
Cdd:cd07538   320 ----------------------TSLVREYPLRPELRMMGQV--WKRPEGAFAAAKGSPEAIIRLCRLNPDEKA-AIEDAV 374
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  756 YTAA--GYRVVALAGKPLPIApslaaaqQLTRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTA 833
Cdd:cd07538   375 SEMAgeGLRVLAVAACRIDES-------FLPDDLEDAVFIFVGLIGLADPLREDVPEAVRICCEAGIRVVMITGDNPATA 447
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  834 VTVARACGMvgaqEHLAVIhathpeqgqpaaleflptessavmngakatgyptvpepqschlaLSGSTFAVLRKhfPKLL 913
Cdd:cd07538   448 KAIAKQIGL----DNTDNV--------------------------------------------ITGQELDAMSD--EELA 477
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568932020  914 PKVlVQATVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISL 967
Cdd:cd07538   478 EKV-RDVNIFARVVPEQKLRIVQAFKANGEIVAMTGDGVNDAPALKAAHIGIAM 530
E1-E2_ATPase pfam00122
E1-E2 ATPase;
369-566 1.48e-31

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 121.91  E-value: 1.48e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   369 LSVRVQVCRPGGEEEwVDSSELVPGDcLVLPQEGGVMPCDAALVAGECVVNESSLTGESTPVLKtalpegpkpycpetHR 448
Cdd:pfam00122    3 LPPTATVLRDGTEEE-VPADELVPGD-IVLLKPGERVPADGRIVEGSASVDESLLTGESLPVEK--------------KK 66
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   449 RHTLFCGTLILQARAyvgprvLAVVTRTGFCTAKGGLVSSILHPRPISFKFYKHSMKFVAALSVLALLGTVYSIIILYRN 528
Cdd:pfam00122   67 GDMVYSGTVVVSGSA------KAVVTATGEDTELGRIARLVEEAKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWLFV 140
                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 568932020   529 RVPVREIVIRALDLVTVVVPPALPAAMTVCTLYAQSRL 566
Cdd:pfam00122  141 GGPPLRALLRALAVLVAACPCALPLATPLALAVGARRL 178
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
279-1041 1.61e-31

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 133.98  E-value: 1.61e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   279 SSGLSLQDQATRKTIYGPNVISIPVK-SYLQLLADEALNPYYGFQAFSIALWLADHYYWYALCIFLISAISICLAL---Y 354
Cdd:TIGR01523   24 PEGLTHDEAQHRLKEVGENRLEADSGiDAKAMLLHQVCNAMCMVLIIAAAISFAMHDWIEGGVISAIIALNILIGFiqeY 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   355 KTRKQSLTLRDMVklSVRVQVCRpGGEEEWVDSSELVPGDCLVLpQEGGVMPCDAALVagECV---VNESSLTGESTPVL 431
Cdd:TIGR01523  104 KAEKTMDSLKNLA--SPMAHVIR-NGKSDAIDSHDLVPGDICLL-KTGDTIPADLRLI--ETKnfdTDEALLTGESLPVI 177
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   432 KTA-LPEGPKPYCPETHRRHTLFCGTLILQARAYvgprvlAVVTRTGFCT----------AKGGLVSSILHPRP----IS 496
Cdd:TIGR01523  178 KDAhATFGKEEDTPIGDRINLAFSSSAVTKGRAK------GICIATALNSeigaiaaglqGDGGLFQRPEKDDPnkrrKL 251
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   497 FKFYKHSMKFVAA--------------LSVLALL----GTVYSIIILYRNRVPV-REIVIRALDLVTVVVPPALPAAMTV 557
Cdd:TIGR01523  252 NKWILKVTKKVTGaflglnvgtplhrkLSKLAVIlfciAIIFAIIVMAAHKFDVdKEVAIYAICLAISIIPESLIAVLSI 331
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   558 CTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFDKTGTLTEDGLDVMGVV-----------------PLKGQV-LLPLVP 619
Cdd:TIGR01523  332 TMAMGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQGKMIARQIWiprfgtisidnsddafnPNEGNVsGIPRFS 411
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   620 E--------------------------PCHLPLG---PLLRALATCHALSQLHDTPV------GDPMDLKM-VESTGWVL 663
Cdd:TIGR01523  412 PyeyshneaadqdilkefkdelkeidlPEDIDMDlfiKLLETAALANIATVFKDDATdcwkahGDPTEIAIhVFAKKFDL 491
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   664 EEGPAAGSapgSQVLVVMRPPPGGPRQQEEPPVPVSV--LCRFPFSSALQRMDVVVTWPGATQPEAYVKGSPELVASLCS 741
Cdd:TIGR01523  492 PHNALTGE---EDLLKSNENDQSSLSQHNEKPGSAQFefIAEFPFDSEIKRMASIYEDNHGETYNIYAKGAFERIIECCS 568
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   742 -----------PETVPSDFSQVLQSYT--AAGYRVVALAGKPLPIA---PSLAAAQQLTRDTVERELSLLGLLVMRNLLK 805
Cdd:TIGR01523  569 ssngkdgvkisPLEDCDRELIIANMESlaAEGLRVLAFASKSFDKAdnnDDQLKNETLNRATAESDLEFLGLIGIYDPPR 648
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   806 PQTAPVIQTLRKTGIRTVMVTGDNLQTAVTVARACGMVGAQehlaVIHATHPEQgqpaaleflpteSSAVMngakatgyp 885
Cdd:TIGR01523  649 NESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGIIPPN----FIHDRDEIM------------DSMVM--------- 703
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   886 tvpepqschlalSGSTFAVLRKHFPKLLPkvlVQATVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGI 965
Cdd:TIGR01523  704 ------------TGSQFDALSDEEVDDLK---ALCLVIARCAPQTKVKMIEALHRRKAFCAMTGDGVNDSPSLKMANVGI 768
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   966 SLSQ------AEASVVSPFTSSMASIecvPTVIREGRcsldtsfsvfkymalySLTQFISVLILYTINTNLGDLQFLAID 1039
Cdd:TIGR01523  769 AMGIngsdvaKDASDIVLSDDNFASI---LNAIEEGR----------------RMFDNIMKFVLHLLAENVAEAILLIIG 829

                   ..
gi 568932020  1040 LV 1041
Cdd:TIGR01523  830 LA 831
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
334-968 8.40e-30

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 125.82  E-value: 8.40e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   334 YYWYALCIFLISAISICLALYKTRKQSLTLRDMVKLS-VRVQVCRPGGEEEWVDSSELVPGDCL-VLPqeGGVMPCDAAL 411
Cdd:TIGR01525   17 LVLEGALLLFLFLLGETLEERAKSRASDALSALLALApSTARVLQGDGSEEEVPVEELQVGDIViVRP--GERIPVDGVV 94
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   412 VAGECVVNESSLTGESTPVLKTalpegpkpycpethRRHTLFCGTLILQARAYVgprvlaVVTRTGFCTAKGGLVSSI-- 489
Cdd:TIGR01525   95 ISGESEVDESALTGESMPVEKK--------------EGDEVFAGTINGDGSLTI------RVTKLGEDSTLAQIVELVee 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   490 --LHPRPISFKFYKHSMKFVAALSVLALLGTVYSIIILYrnrvPVREIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLR 567
Cdd:TIGR01525  155 aqSSKAPIQRLADRIASYYVPAVLAIALLTFVVWLALGA----LWREALYRALTVLVVACPCALGLATPVAILVAIGAAA 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   568 TQGIFCIHPLRINLGGKLRLVCFDKTGTLTEDGLDVMGVVPLKGQVLLplvpepchlplgpLLRALATCHALSQLHdtPV 647
Cdd:TIGR01525  231 RRGILIKGGDALEKLAKVKTVVFDKTGTLTTGKPTVVDIEPLDDASEE-------------ELLALAAALEQSSSH--PL 295
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   648 G----DPMDLKMVESTGWVLEEGPAAGsapgsqvlvvmrpppggprqqeeppvpVSVLCrfpfssalqrmdvvvtwpgAT 723
Cdd:TIGR01525  296 AraivRYAKERGLELPPEDVEEVPGKG---------------------------VEATV-------------------DG 329
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   724 QPEAYVkGSPELVASLCSPETVPSDFSQVLQSYTAAGYRVVALAgkplpiapslaaaqqltrdtveRELSLLGLLVMRNL 803
Cdd:TIGR01525  330 GREVRI-GNPRFLGNRELAIEPISASPDLLNEGESQGKTVVFVA----------------------VDGELLGVIALRDQ 386
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   804 LKPQTAPVIQTLRKTG-IRTVMVTGDNLQTAVTVARACGmvgaqehlavihathpeqgqpaalefLPTEssavmngakat 882
Cdd:TIGR01525  387 LRPEAKEAIAALKRAGgIKLVMLTGDNRSAAEAVAAELG--------------------------IDDE----------- 429
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   883 gyptvpepqschlalsgstfavlrkhfpkllpkvlvqatVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAAD 962
Cdd:TIGR01525  430 ---------------------------------------VHAELLPEDKLAIVKKLQEEGGPVAMVGDGINDAPALAAAD 470

                   ....*.
gi 568932020   963 VGISLS 968
Cdd:TIGR01525  471 VGIAMG 476
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
290-1027 1.26e-29

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 127.13  E-value: 1.26e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  290 RKTIYGPNVISIP-----VKSYLQLladealnpyygFQAFSIALWLAdhyywyALCIFLIS-----AISICLAL------ 353
Cdd:cd02085     1 RRKLHGPNEFKVEdeeplWKKYLEQ-----------FKNPLILLLLG------SAVVSVVMkqyddAVSITVAIlivvtv 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  354 -----YKTRKQSLTLRDMVKLSVRvqvCRPGGEEEWVDSSELVPGDcLVLPQEGGVMPCDAALV-AGECVVNESSLTGES 427
Cdd:cd02085    64 afvqeYRSEKSLEALNKLVPPECH---CLRDGKLEHFLARELVPGD-LVCLSIGDRIPADLRLFeATDLSIDESSLTGET 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  428 TPVLKTALPEGPKPYCPETHRRHTLFCGTLILQARAyvGPRVLAVVTRTGFctakgGLVSSILH----PR-PIsfkfyKH 502
Cdd:cd02085   140 EPCSKTTEVIPKASNGDLTTRSNIAFMGTLVRCGHG--KGIVIGTGENSEF-----GEVFKMMQaeeaPKtPL-----QK 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  503 SM-KFVAALSVLALLGTVYSIIILYRNRVPVREIVIRALDLVTVVVPPALPAAMTVCTLYAQSRL-RTQGIFCIHPLRIN 580
Cdd:cd02085   208 SMdKLGKQLSLYSFIIIGVIMLIGWLQGKNLLEMFTIGVSLAVAAIPEGLPIVVTVTLALGVMRMaKRRAIVKKLPIVET 287
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  581 LGGkLRLVCFDKTGTLTEDGLDVMgvvplkgqvllplvpepcHLPLGpllrALATCHALSQlhDTPVGDPMDLKMVEstg 660
Cdd:cd02085   288 LGC-VNVICSDKTGTLTKNEMTVT------------------KIVTG----CVCNNAVIRN--NTLMGQPTEGALIA--- 339
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  661 wvleegpaagsapgsqvlVVMRPPPGGPRQQeeppvpVSVLCRFPFSSALQRMDVVVTWPGATQPEA--YVKGSPELVAS 738
Cdd:cd02085   340 ------------------LAMKMGLSDIRET------YIRKQEIPFSSEQKWMAVKCIPKYNSDNEEiyFMKGALEQVLD 395
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  739 LC--------SPETV-PSDFSQVLQSYTA---AGYRVVALAgkplpiapSLAAAQQLTrdtverelsLLGLLVMRNLLKP 806
Cdd:cd02085   396 YCttynssdgSALPLtQQQRSEINEEEKEmgsKGLRVLALA--------SGPELGDLT---------FLGLVGINDPPRP 458
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  807 QTAPVIQTLRKTGIRTVMVTGDNLQTAVTVARACGmvgaqehLAVIHathpeqgqpaaleflptessavmngakatgypt 886
Cdd:cd02085   459 GVREAIQILLESGVRVKMITGDAQETAIAIGSSLG-------LYSPS--------------------------------- 498
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  887 vpepqscHLALSGSTFAVLRKHfpkLLPKVLVQATVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGIS 966
Cdd:cd02085   499 -------LQALSGEEVDQMSDS---QLASVVRKVTVFYRASPRHKLKIVKALQKSGAVVAMTGDGVNDAVALKSADIGIA 568
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  967 LSQA------EAS----VVSPFTSSMASIEcvptvirEG-----------RCSLDTSFSVFKYMALYSLTQFISVL---- 1021
Cdd:cd02085   569 MGRTgtdvckEAAdmilVDDDFSTILAAIE-------EGkgifyniknfvRFQLSTSIAALSLIALSTLFNLPNPLnamq 641

                  ....*.
gi 568932020 1022 ILYtIN 1027
Cdd:cd02085   642 ILW-IN 646
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
375-1032 1.90e-28

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 123.94  E-value: 1.90e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  375 VCRPGGEEEWVDSSELVPGDcLVLPQEGGVMPCDAALVAGECV---VNESSLTGESTPVLKTALPEgPKPYCPETHRRHT 451
Cdd:cd02083   125 VLRNGKGVQRIRARELVPGD-IVEVAVGDKVPADIRIIEIKSTtlrVDQSILTGESVSVIKHTDVV-PDPRAVNQDKKNM 202
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  452 LFCGTLILQARAyvgprvLAVVTRTGFCTAKGGLVSSILH----PRPISFKFYKHSMKFVAALSVLALLgtVYSIIILYR 527
Cdd:cd02083   203 LFSGTNVAAGKA------RGVVVGTGLNTEIGKIRDEMAEteeeKTPLQQKLDEFGEQLSKVISVICVA--VWAINIGHF 274
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  528 NRVPVREIVIR--------ALDLVTVVVPPALPAAMTVCTLYAQSRL-RTQGIFCIHPLRINLGgKLRLVCFDKTGTLTE 598
Cdd:cd02083   275 NDPAHGGSWIKgaiyyfkiAVALAVAAIPEGLPAVITTCLALGTRRMaKKNAIVRSLPSVETLG-CTSVICSDKTGTLTT 353
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  599 DGLDVMGVVPLKGQVLLPLVPE-----PCHLPLG--------------PLLRALATCHAL---SQLHdtpvgdpmdlkMV 656
Cdd:cd02083   354 NQMSVSRMFILDKVEDDSSLNEfevtgSTYAPEGevfkngkkvkagqyDGLVELATICALcndSSLD-----------YN 422
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  657 ESTGWVLEEGPAAGSApgSQVLVVMRPPPGG---PRQQEEPPVPVSVLCR--------FPFSSALQRMDVVVTWPGA-TQ 724
Cdd:cd02083   423 ESKGVYEKVGEATETA--LTVLVEKMNVFNTdksGLSKRERANACNDVIEqlwkkeftLEFSRDRKSMSVYCSPTKAsGG 500
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  725 PEAYVKGSPELVASLCS---------PETVPSDFSQVL---QSYTAAGYRVVALAGKPLPIAPSLAAAQQLTRDT-VERE 791
Cdd:cd02083   501 NKLFVKGAPEGVLERCThvrvgggkvVPLTAAIKILILkkvWGYGTDTLRCLALATKDTPPKPEDMDLEDSTKFYkYETD 580
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  792 LSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTVARACGMVGAQEHLAVIHATHPEqgqpaaLEFLPte 871
Cdd:cd02083   581 LTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRRIGIFGEDEDTTGKSYTGRE------FDDLS-- 652
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  872 ssavmngakatgyptvPEPQschlalsgsTFAVLRkhfpkllpkvlvqATVFARMAPEQKTELVCELQRLQYCVGMCGDG 951
Cdd:cd02083   653 ----------------PEEQ---------REACRR-------------ARLFSRVEPSHKSKIVELLQSQGEITAMTGDG 694
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  952 ANDCGALKAADVGISLSQAEAsvVSPFTSSM-------ASIEcvpTVIREGRcsldtsfsvfkymALYSLT-QFISvlil 1023
Cdd:cd02083   695 VNDAPALKKAEIGIAMGSGTA--VAKSASDMvladdnfATIV---AAVEEGR-------------AIYNNMkQFIR---- 752

                  ....*....
gi 568932020 1024 YTINTNLGD 1032
Cdd:cd02083   753 YLISSNIGE 761
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
363-970 4.70e-28

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 121.79  E-value: 4.70e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  363 LRDMVKLSVR-VQVCRpGGEEEWVDSSELVPGDC-LVLPqeGGVMPCDAALVAGECVVNESSLTGESTPVLKTAlpeGpk 440
Cdd:COG2217   204 IRALLSLQPKtARVLR-DGEEVEVPVEELRVGDRvLVRP--GERIPVDGVVLEGESSVDESMLTGESLPVEKTP---G-- 275
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  441 pycpethrrHTLFCGTLILQARAYVgpRVLAVVTRTgfctakggLVSSILH-------PRP----ISFKFykhSMKFVAA 509
Cdd:COG2217   276 ---------DEVFAGTINLDGSLRV--RVTKVGSDT--------TLARIIRlveeaqsSKApiqrLADRI---ARYFVPA 333
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  510 LSVLALLGTVYSIIILYrnrvPVREIVIRAldlVTVVV---PPAL----PAAMTVctlyAQSRLRTQGIFcihpLR---- 578
Cdd:COG2217   334 VLAIAALTFLVWLLFGG----DFSTALYRA---VAVLViacPCALglatPTAIMV----GTGRAARRGIL----IKggea 398
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  579 INLGGKLRLVCFDKTGTLTEDGLDVMGVVPLKGqvllplVPEPCHLPLG---------PLLRALATcHALSQ-LHDTPVG 648
Cdd:COG2217   399 LERLAKVDTVVFDKTGTLTEGKPEVTDVVPLDG------LDEDELLALAaaleqgsehPLARAIVA-AAKERgLELPEVE 471
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  649 DpmdlkmvestgwvLEEGPAAGsapgsqvlvvmrpppggprqqeeppvpvsvlcrfpfssalqrmdVVVTWPGATqpeaY 728
Cdd:COG2217   472 D-------------FEAIPGKG--------------------------------------------VEATVDGKR----V 490
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  729 VKGSPELVASLcsPETVPSDFSQVLQSYTAAGYRVVALAgkplpiapslaaaqqltRDTVerelsLLGLLVMRNLLKPQT 808
Cdd:COG2217   491 LVGSPRLLEEE--GIDLPEALEERAEELEAEGKTVVYVA-----------------VDGR-----LLGLIALADTLRPEA 546
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  809 APVIQTLRKTGIRTVMVTGDNLQTAVTVARACGMvgaqehlavihathpeqgqpaaleflptessavmngakatgyptvp 888
Cdd:COG2217   547 AEAIAALKALGIRVVMLTGDNERTAEAVARELGI---------------------------------------------- 580
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  889 epqschlalsgstfavlrkhfpkllpkvlvqATVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLS 968
Cdd:COG2217   581 -------------------------------DEVRAEVLPEDKAAAVRELQAQGKKVAMVGDGINDAPALAAADVGIAMG 629

                  ..
gi 568932020  969 QA 970
Cdd:COG2217   630 SG 631
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
262-970 2.50e-26

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 117.09  E-value: 2.50e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  262 QVSLLDHGRTCDDVHCSSSGLSLQDQATRKTIYGPNVISI--PVKSYLQLLaDEALNPyygfqaFSIALWLADHYYWY-- 337
Cdd:PRK10517   48 KAAVMPEEELWKTFDTHPEGLNEAEVESAREQHGENELPAqkPLPWWVHLW-VCYRNP------FNILLTILGAISYAte 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  338 ----ALCIFLISAISICLALY---KTRKQSLTLRDMVKLSVRVQVCRPG-GEEEWVDS--SELVPGDCLVLpQEGGVMPC 407
Cdd:PRK10517  121 dlfaAGVIALMVAISTLLNFIqeaRSTKAADALKAMVSNTATVLRVINDkGENGWLEIpiDQLVPGDIIKL-AAGDMIPA 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  408 DA-ALVAGECVVNESSLTGESTPVLKTALPEGPKPYCPethrrhtLFCGTLILQARAYVGPRVLAVVTRTGFCTAKGGLV 486
Cdd:PRK10517  200 DLrILQARDLFVAQASLTGESLPVEKFATTRQPEHSNP-------LECDTLCFMGTNVVSGTAQAVVIATGANTWFGQLA 272
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  487 SSILHP--RPISFKF--YKHSMKFVAALSVLAllgtvysIIILYRN---RVPVREIVIRALDLVTVVVPPALPaaMTVCT 559
Cdd:PRK10517  273 GRVSEQdsEPNAFQQgiSRVSWLLIRFMLVMA-------PVVLLINgytKGDWWEAALFALSVAVGLTPEMLP--MIVTS 343
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  560 LYAQS--RLRTQGIFCIHPLRINLGGKLRLVCFDKTGTLTEDGL------DVMGvvplkgqvllplvpEPCHlplGPLLR 631
Cdd:PRK10517  344 TLARGavKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKIvlenhtDISG--------------KTSE---RVLHS 406
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  632 ALATCH---ALSQLHDTPVGDPMDL--KMVESTGWvleegpaagsapgsqvlvvmrpppggpRQQEEppvpvsvlcrFPF 706
Cdd:PRK10517  407 AWLNSHyqtGLKNLLDTAVLEGVDEesARSLASRW---------------------------QKIDE----------IPF 449
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  707 SSALQRMDVVVTWPGAtQPEAYVKGSPELVASLCS-----PETVPSDFS------QVLQSYTAAGYRVVALAGKPLPiap 775
Cdd:PRK10517  450 DFERRRMSVVVAENTE-HHQLICKGALEEILNVCSqvrhnGEIVPLDDImlrrikRVTDTLNRQGLRVVAVATKYLP--- 525
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  776 slaAAQQLTRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAvtvARACGMVGAqEHLAVIHAT 855
Cdd:PRK10517  526 ---AREGDYQRADESDLILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSELVA---AKVCHEVGL-DAGEVLIGS 598
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  856 HPEQgqpaaleflptessavMNGAKatgyptvpepqschlalsgstfavlrkhfpklLPKVLVQATVFARMAPEQKTELV 935
Cdd:PRK10517  599 DIET----------------LSDDE--------------------------------LANLAERTTLFARLTPMHKERIV 630
                         730       740       750
                  ....*....|....*....|....*....|....*
gi 568932020  936 CELQRLQYCVGMCGDGANDCGALKAADVGISLSQA 970
Cdd:PRK10517  631 TLLKREGHVVGFMGDGINDAPALRAADIGISVDGA 665
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
330-976 1.17e-23

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 107.02  E-value: 1.17e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   330 LADHYYWYALCIFLISAISICLALYKTRKQSLTLRDMVKLSVRVQVCRPGGEEEWVDSSELVPGDcLVLPQEGGVMPCDA 409
Cdd:TIGR01512   13 VAIGEYLEGALLLLLFSIGETLEEYASGRARRALKALMELAPDTARRLQGDSLEEVAVEELKVGD-VVVVKPGERVPVDG 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   410 ALVAGECVVNESSLTGESTPVLKTalpegpkpycpethRRHTLFCGTLILQARAYVgprvlaVVTRTGFCTAKGGLVSSI 489
Cdd:TIGR01512   92 EVLSGTSSVDESALTGESVPVEKA--------------PGDEVFAGAINLDGVLTI------EVTKLPADSTIAKIVNLV 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   490 LHPRPISFKFYKHSMKFVAALSVLALLGTVYSIIILYR-NRVPVREIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRT 568
Cdd:TIGR01512  152 EEAQSRKAPTQRFIDRFARYYTPAVLAIALAAALVPPLlGAGPFLEWIYRALVLLVVASPCALVISAPAAYLSAISAAAR 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   569 QGIFCIHPLRINLGGKLRLVCFDKTGTLTEDGLDVMGVVPLKGQVLlplvpepchlplgPLLRALATCHALSQLHdtpvg 648
Cdd:TIGR01512  232 HGILIKGGAALEALAKIKTVAFDKTGTLTTGKPKVTDVHPADGHSE-------------SEVLRLAAAAEQGSTH----- 293
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   649 dPMDLKMVESTgwvleegpaagsapgsqvlvvmrpppggprQQEEPPVPVSVLCRFPFSSALQRMDVVVTWPGATQpeay 728
Cdd:TIGR01512  294 -PLARAIVDYA------------------------------RARELAPPVEDVEEVPGEGVRAVVDGGEVRIGNPR---- 338
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   729 vKGSPELVASLCSPETVPSDFSqvlqsytaagyrVVALAGKplpiapslaaaqqltrdtverelsLLGLLVMRNLLKPQT 808
Cdd:TIGR01512  339 -SLSEAVGASIAVPESAGKTIV------------LVARDGT------------------------LLGYIALSDELRPDA 381
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   809 APVIQTLRKTGI-RTVMVTGDNLQTAVTVARAcgmVGAQEhlavihathpeqgqpaaleflptessavmngakatgyptv 887
Cdd:TIGR01512  382 AEAIAELKALGIkRLVMLTGDRRAVAEAVARE---LGIDE---------------------------------------- 418
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   888 pepqschlalsgstfavlrkhfpkllpkvlvqatVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISL 967
Cdd:TIGR01512  419 ----------------------------------VHAELLPEDKLEIVKELREKAGPVAMVGDGINDAPALAAADVGIAM 464

                   ....*....
gi 568932020   968 SQAEASVVS 976
Cdd:TIGR01512  465 GASGSDVAL 473
P5-ATPase pfam12409
P5-type ATPase cation transporter; This domain family is found in eukaryotes, and is typically ...
35-110 5.94e-23

P5-type ATPase cation transporter; This domain family is found in eukaryotes, and is typically between 110 and 126 amino acids in length. The family is found in association with pfam00122, pfam00702. P-type ATPases comprise a large superfamily of proteins, present in both prokaryotes and eukaryotes, that transport inorganic cations and other substrates across cell membranes.


Pssm-ID: 463565  Cd Length: 123  Bit Score: 95.30  E-value: 5.94e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568932020    35 VRLSGYCGSPWRAIGYHAAVWMLAGIPWLLFRWKPLWGVRLRLKPCSLAHAETLVIeikdkEGSSRQLFTVQVQTE 110
Cdd:pfam12409    5 IEIAGYRTSRWRLALYLLLCVLTLGLLYLLFRWLPRWRVRLTGKPCPLAEADWVVI-----EDEFGELSIKKVKKL 75
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
262-1105 9.84e-23

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 105.64  E-value: 9.84e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   262 QVSLLDHGRTCDDVHCS-----SSGLSLQDQATRKTIYGPNVISIP------VKSYLQLladealnpyygFQAFSIALWL 330
Cdd:TIGR01106   12 EVEMDDHKLSLDELERKygtdlSKGLSAARAAEILARDGPNALTPPpttpewVKFCRQL-----------FGGFSMLLWI 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   331 ADHYYWYALCI----------------FLISAISI---CLALYKTRKQSLTLRDMVKLSVRVQVCRPGGEEEWVDSSELV 391
Cdd:TIGR01106   81 GAILCFLAYGIqasteeepqndnlylgVVLSAVVIitgCFSYYQEAKSSKIMESFKNMVPQQALVIRDGEKMSINAEQVV 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   392 PGDcLVLPQEGGVMPCDAALVAGE-CVVNESSLTGESTPvlKTALPEGPKPYCPEThrRHTLFCGTLILQARAyvgprvL 470
Cdd:TIGR01106  161 VGD-LVEVKGGDRIPADLRIISAQgCKVDNSSLTGESEP--QTRSPEFTHENPLET--RNIAFFSTNCVEGTA------R 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   471 AVVTRTGFCTAKG---GLVSSILHPR-PISFKFyKHSMKFVAALSV-LALLGTVYSIIILYRnrvpVREIVIRALDLVTV 545
Cdd:TIGR01106  230 GIVVNTGDRTVMGriaSLASGLENGKtPIAIEI-EHFIHIITGVAVfLGVSFFILSLILGYT----WLEAVIFLIGIIVA 304
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   546 VVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFDKTGTLTEDGLDVMGVVpLKGQVLLPLVPE----P 621
Cdd:TIGR01106  305 NVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMW-FDNQIHEADTTEdqsgV 383
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   622 CHLPLGPLLRALATCHALSQLHDTPVGD---PMDLKMVestgwvleegpaAGSAPGSQVLVVMRPPPGGPRQQEEPPVPV 698
Cdd:TIGR01106  384 SFDKSSATWLALSRIAGLCNRAVFKAGQenvPILKRAV------------AGDASESALLKCIELCLGSVMEMRERNPKV 451
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   699 svlCRFPFSSALQRMDVVVTWPGATQPE--AYVKGSPELVASLCSP-----ETVPSDfSQVLQSYTAA-------GYRVV 764
Cdd:TIGR01106  452 ---VEIPFNSTNKYQLSIHENEDPRDPRhlLVMKGAPERILERCSSilihgKEQPLD-EELKEAFQNAylelgglGERVL 527
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   765 ALAGKPLPiAPSLAAAQQLTRDTVE---RELSLLGLLVMrnlLKPQTAPV---IQTLRKTGIRTVMVTGDNLQTAVTVAR 838
Cdd:TIGR01106  528 GFCHLYLP-DEQFPEGFQFDTDDVNfptDNLCFVGLISM---IDPPRAAVpdaVGKCRSAGIKVIMVTGDHPITAKAIAK 603
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   839 ACGMVGA----QEHLAVIHATHPEQGQPAaleflpTESSAVMNGAKatgyptvpepqschlalsgstfavLRKHFPKLLP 914
Cdd:TIGR01106  604 GVGIISEgnetVEDIAARLNIPVSQVNPR------DAKACVVHGSD------------------------LKDMTSEQLD 653
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   915 KVLVQAT--VFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQAeASVVSPFTSSM-------ASI 985
Cdd:TIGR01106  654 EILKYHTeiVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIA-GSDVSKQAADMillddnfASI 732
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   986 ecvPTVIREGRCSLDTsfsvFKYMALYSLTQFIS------VLILYTINTNLGDLQFLAIDLVITTTVAVLMSRTGPALTL 1059
Cdd:TIGR01106  733 ---VTGVEEGRLIFDN----LKKSIAYTLTSNIPeitpflIFIIANIPLPLGTITILCIDLGTDMVPAISLAYEKAESDI 805
                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568932020  1060 VRARPPGA----LLSVPVLGSLLLQVALVAGiqLGG---YFLVIAQPWFVPLN 1105
Cdd:TIGR01106  806 MKRQPRNPktdkLVNERLISMAYGQIGMIQA--LGGfftYFVILAENGFLPLH 856
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
323-972 4.90e-22

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 102.29  E-value: 4.90e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  323 AFSIALWLADH----YYWYA---LCIFLISAISICLALYKTRKQSLTLRDMVKLSVRVQvcRPGGEEEwVDSSELVPGD- 394
Cdd:cd02079    72 AFVASLLTPLLggigYFEEAamlLFLFLLGRYLEERARSRARSALKALLSLAPETATVL--EDGSTEE-VPVDDLKVGDv 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  395 CLVLPqeGGVMPCDAALVAGECVVNESSLTGESTPVLKTAlpeGpkpycpethrrHTLFCGTLILQArayvgprVLAV-V 473
Cdd:cd02079   149 VLVKP--GERIPVDGVVVSGESSVDESSLTGESLPVEKGA---G-----------DTVFAGTINLNG-------PLTIeV 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  474 TRTGfctaKGGLVSSILH---------PRPISF--KFYKHSMKFVAALSVLALLGTVYSiiilyrnRVPVREIVIRALDL 542
Cdd:cd02079   206 TKTG----EDTTLAKIIRlveeaqsskPPLQRLadRFARYFTPAVLVLAALVFLFWPLV-------GGPPSLALYRALAV 274
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  543 VTVVVPPAL----PAAMTVctlyAQSRLRTQGIFcihpLRinlGG-------KLRLVCFDKTGTLTEDGLDVMGVVPLKG 611
Cdd:cd02079   275 LVVACPCALglatPTAIVA----GIGRAARKGIL----IK---GGdvletlaKVDTVAFDKTGTLTEGKPEVTEIEPLEG 343
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  612 QVllplvpepchlpLGPLLRALA-----TCHALSQ-LHDTPVGDPMDLKMVEStgwvLEEGPAAGsapgsqvlvvmrppp 685
Cdd:cd02079   344 FS------------EDELLALAAaleqhSEHPLARaIVEAAEEKGLPPLEVED----VEEIPGKG--------------- 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  686 ggprqqeeppvpvsvlcrfpfssalqrmdVVVTWPGATqpeaYVKGSPELVASLCSPETVpsdfsQVLQSYTAAGYRVVA 765
Cdd:cd02079   393 -----------------------------ISGEVDGRE----VLIGSLSFAEEEGLVEAA-----DALSDAGKTSAVYVG 434
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  766 LAGKplpiapslaaaqqltrdtverelsLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTVARACGMvga 845
Cdd:cd02079   435 RDGK------------------------LVGLFALEDQLRPEAKEVIAELKSGGIKVVMLTGDNEAAAQAVAKELGI--- 487
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  846 qehlavihathpeqgqpaaleflptessavmngakatgyptvpepqschlalsgstfavlrkhfpkllpkvlvqATVFAR 925
Cdd:cd02079   488 --------------------------------------------------------------------------DEVHAG 493
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|....*..
gi 568932020  926 MAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQAEA 972
Cdd:cd02079   494 LLPEDKLAIVKALQAEGGPVAMVGDGINDAPALAQADVGIAMGSGTD 540
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
700-971 1.14e-21

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 101.91  E-value: 1.14e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  700 VLCRFPFSSALQRMDVVVTWPGATQPEAYVKGSPELVASLCSPETVPSDFSQVLQSYTAAGYRVVALAGKPLP------I 773
Cdd:cd07536   393 ILQLLEFTSDRKRMSVIVRDESTGEITLYMKGADVAISPIVSKDSYMEQYNDWLEEECGEGLRTLCVAKKALTeneyqeW 472
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  774 APSLAAAQQLTRD----------TVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTVARACGMV 843
Cdd:cd07536   473 ESRYTEASLSLHDrslrvaevveSLERELELLGLTAIEDRLQAGVPETIETLRKAGIKIWMLTGDKQETAICIAKSCHLV 552
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  844 GaqehlavihathPEQGQPAALEFLPTESSAVMNGAKATGYPTVPEPQSCHLALSGSTFAVLRKHFPKLLPKVLVQ--AT 921
Cdd:cd07536   553 S------------RTQDIHLLRQDTSRGERAAITQHAHLELNAFRRKHDVALVIDGDSLEVALKYYRHEFVELACQcpAV 620
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568932020  922 VFARMAPEQKTELVCELQ-RLQYCVGMCGDGANDCGALKAADVGISLSQAE 971
Cdd:cd07536   621 ICCRVSPTQKARIVTLLKqHTGRRTLAIGDGGNDVSMIQAADCGVGISGKE 671
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
334-965 5.68e-21

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 98.86  E-value: 5.68e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  334 YYWY--ALCIFlISAISICLALYKTRKQSLTLRDMVKLS-VRVQVCRPGGEEEWVDSSELVPGDC-LVLPqeGGVMPCDA 409
Cdd:cd07551    73 GYWAegALLIF-IFSLSHALEDYAMGRSKRAITALMQLApETARRIQRDGEIEEVPVEELQIGDRvQVRP--GERVPADG 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  410 ALVAGECVVNESSLTGESTPVLKTalpegpkpycpethRRHTLFCGTLilqarayVGPRVLAV-VTRtgfcTAKGGLVSS 488
Cdd:cd07551   150 VILSGSSSIDEASITGESIPVEKT--------------PGDEVFAGTI-------NGSGALTVrVTK----LSSDTVFAK 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  489 ILH---------PRPISF--KFYKHSMKFVAALsVLALLgtvysIIILYRNRVPVREIVIRALDLVTVVVPPALPAAMTV 557
Cdd:cd07551   205 IVQlveeaqsekSPTQSFieRFERIYVKGVLLA-VLLLL-----LLPPFLLGWTWADSFYRAMVFLVVASPCALVASTPP 278
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  558 CTLYAQSRLRTQGIFC---IHPLRInlgGKLRLVCFDKTGTLTEDGLDVMGVVPLKGqvllplVPEpcHLplgpLLRALA 634
Cdd:cd07551   279 ATLSAIANAARQGVLFkggVHLENL---GSVKAIAFDKTGTLTEGKPRVTDVIPAEG------VDE--EE----LLQVAA 343
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  635 tchALSQLHDTPVGDPMdlkmvestgwvLEEGpaagsapgsqvlvvmrpppggpRQQEEPPVPVSVLcrfpfsSALQRMD 714
Cdd:cd07551   344 ---AAESQSEHPLAQAI-----------VRYA----------------------EERGIPRLPAIEV------EAVTGKG 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  715 VVVTWPGATqpeaYVKGSPELVASLCSPETVpSDFSQVLQSytaAGYRVValagkplpiapslaaaqqltrdTVERELSL 794
Cdd:cd07551   382 VTATVDGQT----YRIGKPGFFGEVGIPSEA-AALAAELES---EGKTVV----------------------YVARDDQV 431
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  795 LGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTVARACGMvgaqehlavihathpeqgqpaaleflpTEssa 874
Cdd:cd07551   432 VGLIALMDTPRPEAKEAIAALRLGGIKTIMLTGDNERTAEAVAKELGI---------------------------DE--- 481
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  875 vmngakatgyptvpepqschlalsgstfavlrkhfpkllpkvlvqatVFARMAPEQKTELVCELQRLQYCVGMCGDGAND 954
Cdd:cd07551   482 -----------------------------------------------VVANLLPEDKVAIIRELQQEYGTVAMVGDGIND 514
                         650
                  ....*....|.
gi 568932020  955 CGALKAADVGI 965
Cdd:cd07551   515 APALANADVGI 525
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
329-968 7.08e-21

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 98.12  E-value: 7.08e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   329 WLADHYYWYALCiFLISAISI-----CLALYKTRKqslTLRDMVKLSVR-VQVCRPGGEEEWVDSSELVPGDCL-VLPqe 401
Cdd:TIGR01511   47 GLHVHTFFDASA-MLITFILLgrwleMLAKGRASD---ALSKLAKLQPStATLLTKDGSIEEVPVALLQPGDIVkVLP-- 120
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   402 GGVMPCDAALVAGECVVNESSLTGESTPVLKTalpEGpkpycpethrrHTLFCGTLilqarayVGPRVLAV-VTRTGFCT 480
Cdd:TIGR01511  121 GEKIPVDGTVIEGESEVDESLVTGESLPVPKK---VG-----------DPVIAGTV-------NGTGSLVVrATATGEDT 179
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   481 -----------AKGG---------LVSSILHPrpisfkfykhsmkFVAALSVLALLGTVYSIIILyrnrvpvreiviral 540
Cdd:TIGR01511  180 tlaqivrlvrqAQQSkapiqrladKVAGYFVP-------------VVIAIALITFVIWLFALEFA--------------- 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   541 dlVTVVV---PPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFDKTGTLTEDGLDVMGVvplkgqvllpl 617
Cdd:TIGR01511  232 --VTVLIiacPCALGLATPTVIAVATGLAAKNGVLIKDGDALERAANIDTVVFDKTGTLTQGKPTVTDV----------- 298
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   618 vpepchLPLGPLLR--ALATCHALSQLHDTPVGdpmdlkmVESTGWVLEEGPAAGSAPGSQVLvvmrppPGgprqqeepp 695
Cdd:TIGR01511  299 ------HVFGDRDRteLLALAAALEAGSEHPLA-------KAIVSYAKEKGITLVTVSDFKAI------PG--------- 350
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   696 vpvsvlcrfpfssalqrmdVVVTwpGATQPEAYVKGSPELVaslcspetvpsdfsqvlqsytaagyrvvalagKPLPIAP 775
Cdd:TIGR01511  351 -------------------IGVE--GTVEGTKIQLGNEKLL--------------------------------GENAIKI 377
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   776 SLAAAQQLTRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTVARACGMvgaqehlavihat 855
Cdd:TIGR01511  378 DGKAGQGSTVVLVAVNGELAGVFALEDQLRPEAKEVIQALKRRGIEPVMLTGDNRKTAKAVAKELGI------------- 444
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   856 hpeqgqpaaleflptessavmngakatgyptvpepqschlalsgstfavlrkhfpkllpkvlvqaTVFARMAPEQKTELV 935
Cdd:TIGR01511  445 -----------------------------------------------------------------DVRAEVLPDDKAALI 459
                          650       660       670
                   ....*....|....*....|....*....|...
gi 568932020   936 CELQRLQYCVGMCGDGANDCGALKAADVGISLS 968
Cdd:TIGR01511  460 KKLQEKGPVVAMVGDGINDAPALAQADVGIAIG 492
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
275-966 7.56e-19

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 92.78  E-value: 7.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  275 VHCSSSGLSLQDQATRKTIYGPNVIS--IPVKSYLQLLAdeAL-NPY-YGFQAFSIALWLADhyYWYAL----------C 340
Cdd:PRK15122   39 LNTHRQGLTEEDAAERLQRYGPNEVAheKPPHALVQLLQ--AFnNPFiYVLMVLAAISFFTD--YWLPLrrgeetdltgV 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  341 IFLISAISICLAL-----YKTRKQSLTLRDMVKLSV----RVQVCRPGGEEEwVDSSELVPGDCLVLpQEGGVMPCDAAL 411
Cdd:PRK15122  115 IIILTMVLLSGLLrfwqeFRSNKAAEALKAMVRTTAtvlrRGHAGAEPVRRE-IPMRELVPGDIVHL-SAGDMIPADVRL 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  412 VAG-ECVVNESSLTGESTPVLK---TALPEGPKPYCPETHRRHTL------FCGTLILQARAyvgprvLAVVTRTGFCTA 481
Cdd:PRK15122  193 IESrDLFISQAVLTGEALPVEKydtLGAVAGKSADALADDEGSLLdlpnicFMGTNVVSGTA------TAVVVATGSRTY 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  482 KGGLVSSILHPRP-ISFKfykhsmKFVAALSVLallgtvysIIILYRNRVPV------------REIVIRALDLVTVVVP 548
Cdd:PRK15122  267 FGSLAKSIVGTRAqTAFD------RGVNSVSWL--------LIRFMLVMVPVvllingftkgdwLEALLFALAVAVGLTP 332
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  549 PALPaaMTVCTLYAQ------------SRLRTQGIFcihplrinlgGKLRLVCFDKTGTLTEDG------LDVMGVVPLK 610
Cdd:PRK15122  333 EMLP--MIVSSNLAKgaiamarrkvvvKRLNAIQNF----------GAMDVLCTDKTGTLTQDRiilehhLDVSGRKDER 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  611 gqVLlplvpepchlplgpllrALATchaLSQLHDTPVGDPMDLKMVEStgwvleegpaAGSAPGSQvlvvmrpPPGGPRQ 690
Cdd:PRK15122  401 --VL-----------------QLAW---LNSFHQSGMKNLMDQAVVAF----------AEGNPEIV-------KPAGYRK 441
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  691 QEEppvpvsvlcrFPFSSALQRMDVVVTWPGATQpEAYVKGSPELVASLCS-----PETVPSDFS---QVLQ---SYTAA 759
Cdd:PRK15122  442 VDE----------LPFDFVRRRLSVVVEDAQGQH-LLICKGAVEEMLAVAThvrdgDTVRPLDEArreRLLAlaeAYNAD 510
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  760 GYRVVALAGKPLPIAPSlaaAQQLTRDTvERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNlqtAVTVARA 839
Cdd:PRK15122  511 GFRVLLVATREIPGGES---RAQYSTAD-ERDLVIRGFLTFLDPPKESAAPAIAALRENGVAVKVLTGDN---PIVTAKI 583
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  840 CGMVGAqehlavihathpEQGQPaaleflptessavmngakatgyptvpepqschlaLSGSTFAVLRKhfpKLLPKVLVQ 919
Cdd:PRK15122  584 CREVGL------------EPGEP----------------------------------LLGTEIEAMDD---AALAREVEE 614
                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*..
gi 568932020  920 ATVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGIS 966
Cdd:PRK15122  615 RTVFAKLTPLQKSRVLKALQANGHTVGFLGDGINDAPALRDADVGIS 661
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
375-965 2.34e-18

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 90.62  E-value: 2.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  375 VCRPGGEEEwVDSSELVPGDCL-VLPqeGGVMPCDAALVAGECVVNESSLTGESTPVLKTalpEGpkpycpethrrHTLF 453
Cdd:cd02094   143 VIRDGKEVE-VPIEEVQVGDIVrVRP--GEKIPVDGVVVEGESSVDESMLTGESLPVEKK---PG-----------DKVI 205
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  454 CGTLILQARayvgprVLAVVTRTGfctaKGGLVSSILH---------PrPISfKFY-KHSMKFVAALSVLALLGTVYSII 523
Cdd:cd02094   206 GGTINGNGS------LLVRATRVG----ADTTLAQIIRlveeaqgskA-PIQ-RLAdRVSGVFVPVVIAIAILTFLVWLL 273
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  524 ILYRNRVpvreivIRALDL-VTVVV---PPAL----PAAMTVCT-LYAQsrlrtQGIFcihplrINLG------GKLRLV 588
Cdd:cd02094   274 LGPEPAL------TFALVAaVAVLViacPCALglatPTAIMVGTgRAAE-----LGIL------IKGGealeraHKVDTV 336
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  589 CFDKTGTLTEDGLDVMGVVPLKGQVLlplvpepchlplGPLLRALATCHALSQlHdtPVGDPMdLKMVESTGWVLEEGPA 668
Cdd:cd02094   337 VFDKTGTLTEGKPEVTDVVPLPGDDE------------DELLRLAASLEQGSE-H--PLAKAI-VAAAKEKGLELPEVED 400
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  669 AGSAPGSQVLvvmrpppggprqqeeppvpvsvlcrfpfssalqrmdvvvtwpGATQPEAYVKGSPELVASLcspETVPSD 748
Cdd:cd02094   401 FEAIPGKGVR------------------------------------------GTVDGRRVLVGNRRLMEEN---GIDLSA 435
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  749 FSQVLQSYTAAGYRVVALAgkplpiapslaaaqqltrdtVERELslLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGD 828
Cdd:cd02094   436 LEAEALALEEEGKTVVLVA--------------------VDGEL--AGLIAVADPLKPDAAEAIEALKKMGIKVVMLTGD 493
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  829 NLQTAVTVARACGMvgaqehlavihathpeqgqpaaleflptessavmngakatgyptvpepqschlalsgstfavlrkh 908
Cdd:cd02094   494 NRRTARAIAKELGI------------------------------------------------------------------ 507
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568932020  909 fpkllpkvlvqATVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGI 965
Cdd:cd02094   508 -----------DEVIAEVLPEDKAEKVKKLQAQGKKVAMVGDGINDAPALAQADVGI 553
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
281-1040 6.42e-17

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 86.63  E-value: 6.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  281 GLSLQDQATRKTIYGPNVISIP------VKSYLQLladealnpyygFQAFSIALWLA--------------------DHY 334
Cdd:cd02608     1 GLTSARAAEILARDGPNALTPPpttpewVKFCKQL-----------FGGFSMLLWIGailcflaygiqaateeepsnDNL 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  335 YwyaLCIFLISAISI--CLALYKTRKQSL---TLRDMV---KLSVRvqvcrpGGEEEWVDSSELVPGDcLVLPQEGGVMP 406
Cdd:cd02608    70 Y---LGIVLAAVVIVtgCFSYYQEAKSSKimdSFKNMVpqqALVIR------DGEKMQINAEELVVGD-LVEVKGGDRIP 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  407 CDAALV-AGECVVNESSLTGESTPvlKTALPEGPKPYCPEThrRHTLFCGTLILQARAYvgprvlAVVTRTGFCTAKG-- 483
Cdd:cd02608   140 ADIRIIsAHGCKVDNSSLTGESEP--QTRSPEFTHENPLET--KNIAFFSTNCVEGTAR------GIVINTGDRTVMGri 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  484 -GLVSSI-LHPRPISfKFYKHSMKFVAALSVLalLGTVYSIIIL---YrnrvPVREIVIRALDLVTVVVPPALPAAMTVC 558
Cdd:cd02608   210 aTLASGLeVGKTPIA-REIEHFIHIITGVAVF--LGVSFFILSLilgY----TWLEAVIFLIGIIVANVPEGLLATVTVC 282
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  559 -TLYAQsRLRTQgiFCihpLRINLG-----GKLRLVCFDKTGTLTEDGldvMGVVPL--KGQVLLPLVPEP----CHLPL 626
Cdd:cd02608   283 lTLTAK-RMARK--NC---LVKNLEavetlGSTSTICSDKTGTLTQNR---MTVAHMwfDNQIHEADTTEDqsgaSFDKS 353
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  627 GPLLRALATCHAL-------SQLHDTPV------GDPMD---LKMVE-STGWVLEegpaagsapgsqvlvvMRpppggpr 689
Cdd:cd02608   354 SATWLALSRIAGLcnraefkAGQENVPIlkrdvnGDASEsalLKCIElSCGSVME----------------MR------- 410
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  690 qQEEPPVpvsvlCRFPFSSAlQRMDVVVTWPGATQPEAYV---KGSPELVASLCSP-----ETVPSD------FSQVLQS 755
Cdd:cd02608   411 -ERNPKV-----AEIPFNST-NKYQLSIHENEDPGDPRYLlvmKGAPERILDRCSTilingKEQPLDeemkeaFQNAYLE 483
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  756 YTAAGYRVVALAGKPLPiAPSLAAAQQLTRDTVE---RELSLLGLLVMrnlLKPQTAPVIQTLRK---TGIRTVMVTGDN 829
Cdd:cd02608   484 LGGLGERVLGFCHLYLP-DDKFPEGFKFDTDEVNfptENLCFVGLMSM---IDPPRAAVPDAVGKcrsAGIKVIMVTGDH 559
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  830 LQTAVTVARACGMVgaqehlavihathpeqgqpaaleflptessavmngakatgyptvpepqschlalsgstfavlrkhf 909
Cdd:cd02608   560 PITAKAIAKGVGII------------------------------------------------------------------ 573
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  910 pkllpkvlvqatVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQAeASVVSPFTSSM------- 982
Cdd:cd02608   574 ------------VFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIA-GSDVSKQAADMillddnf 640
                         810       820       830       840       850       860
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568932020  983 ASIecvPTVIREGRCSLDTsfsvFKYMALYSLTQFIS------VLILYTINTNLGDLQFLAIDL 1040
Cdd:cd02608   641 ASI---VTGVEEGRLIFDN----LKKSIAYTLTSNIPeitpflIFIIANIPLPLGTITILCIDL 697
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
355-970 1.47e-15

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 81.55  E-value: 1.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  355 KTRKQSLTLRDMVKLSVRVQVcrpGGEEEWVDSSELVPGDCLVLpQEGGVMPCDAALVAGECVVNESSLTGESTPVLKTa 434
Cdd:cd07550    86 KSEKALLDLLSPQERTVWVER---DGVEVEVPADEVQPGDTVVV-GAGDVIPVDGTVLSGEALIDQASLTGESLPVEKR- 160
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  435 lpEGpkpycpethrrHTLFCGTLILQARAYVgprvlaVVTRTGFCTAKGGLV----SSILHPRPISFKFYKHSMKfvAAL 510
Cdd:cd07550   161 --EG-----------DLVFASTVVEEGQLVI------RAERVGRETRAARIAelieQSPSLKARIQNYAERLADR--LVP 219
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  511 SVLALLGTVYSIIilyrnRVPVREIVIRALDLVT---VVVPPALPAAMTVCTlyaqsrlrTQGIFCIHPLRINLGGKLRL 587
Cdd:cd07550   220 PTLGLAGLVYALT-----GDISRAAAVLLVDFSCgirLSTPVAVLSALNHAA--------RHGILVKGGRALELLAKVDT 286
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  588 VCFDKTGTLTEDGLDVMGVVPLKGQV----LLPL---VPEpcHLPLgPLLRALATcHALSQlhdtpvgdpmDLKMVESTG 660
Cdd:cd07550   287 VVFDKTGTLTEGEPEVTAIITFDGRLseedLLYLaasAEE--HFPH-PVARAIVR-EAEER----------GIEHPEHEE 352
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  661 WVLEEGPAAGSAPGSQVLVVmrpppggprqqeeppvpvsvlcrfpfssalqrmdvvvtwpgatqpeayvkGSPELVASLC 740
Cdd:cd07550   353 VEYIVGHGIASTVDGKRIRV--------------------------------------------------GSRHFMEEEE 382
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  741 SPETVPSDfsQVLQSYTAAGYRVVALAgkplpiapslaaaqqltrdtVERELslLGLLVMRNLLKPQTAPVIQTLRKTGI 820
Cdd:cd07550   383 IILIPEVD--ELIEDLHAEGKSLLYVA--------------------IDGRL--IGVIGLSDPLRPEAAEVIARLRALGG 438
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  821 RTV-MVTGDNLQTAVTVARACGMVGaqehlavihathpeqgqpaaleflptessavmngakatgyptvpepqschlalsg 899
Cdd:cd07550   439 KRIiMLTGDHEQRARALAEQLGIDR------------------------------------------------------- 463
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568932020  900 stfavlrkhfpkllpkvlvqatVFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISLSQA 970
Cdd:cd07550   464 ----------------------YHAEALPEDKAEIVEKLQAEGRTVAFVGDGINDSPALSYADVGISMRGG 512
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
338-970 2.24e-15

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 80.93  E-value: 2.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  338 ALCIFLIsAISICLALYKTRKQSLTLRDMVKLSVRVQVCRPGGEEEWVDSSELVPGDcLVLPQEGGVMPCDAALVAGECV 417
Cdd:cd07545    63 AMVVFLF-AISEALEAYSMDRARRSIRSLMDIAPKTALVRRDGQEREVPVAEVAVGD-RMIVRPGERIAMDGIIVRGESS 140
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  418 VNESSLTGESTPVLKTAlpegpkpycpethrRHTLFCGTLilqarayVGPRVLAV-VTRTgfctAKGGLVSSILH----- 491
Cdd:cd07545   141 VNQAAITGESLPVEKGV--------------GDEVFAGTL-------NGEGALEVrVTKP----AEDSTIARIIHlveea 195
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  492 --PRPISFKFY-KHSMKFVAALSVLALLGTVYSIIILYRNRVPVreiVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRT 568
Cdd:cd07545   196 qaERAPTQAFVdRFARYYTPVVMAIAALVAIVPPLFFGGAWFTW---IYRGLALLVVACPCALVISTPVSIVSAIGNAAR 272
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  569 QGIFCIHPLRINLGGKLRLVCFDKTGTLTEDGLDVMGVVPLKGQVLLplvpepchlplgpllRALATCHALSQLHDTPVG 648
Cdd:cd07545   273 KGVLIKGGVYLEELGRLKTVAFDKTGTLTKGKPVVTDVVVLGGQTEK---------------ELLAIAAALEYRSEHPLA 337
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  649 DPmdlkmvestgwVLEEGpaagsapgsqvlvvmrpppggprqqEEPPVPVSVLCRFpfsSALQRMDVVVTWPGatqpEAY 728
Cdd:cd07545   338 SA-----------IVKKA-------------------------EQRGLTLSAVEEF---TALTGRGVRGVVNG----TTY 374
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  729 VKGSPELVASLCSPETVPsdFSQVLQSYTAAGYRVVALagkplpiapslaaaqqLTRDTVerelslLGLLVMRNLLKPQT 808
Cdd:cd07545   375 YIGSPRLFEELNLSESPA--LEAKLDALQNQGKTVMIL----------------GDGERI------LGVIAVADQVRPSS 430
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  809 APVIQTLRKTGI-RTVMVTGDNLQTAVTVARACGMVGAQehlavihathpeqgqpaaleflptessavmngakatgyptv 887
Cdd:cd07545   431 RNAIAALHQLGIkQTVMLTGDNPQTAQAIAAQVGVSDIR----------------------------------------- 469
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  888 pepqschlalsgstfavlrkhfpkllpkvlvqatvfARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISL 967
Cdd:cd07545   470 ------------------------------------AELLPQDKLDAIEALQAEGGRVAMVGDGVNDAPALAAADVGIAM 513

                  ...
gi 568932020  968 SQA 970
Cdd:cd07545   514 GAA 516
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
699-979 3.53e-15

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 80.53  E-value: 3.53e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  699 SVLCRFPFSSALQRMDVVVTWPGATQPEAYVKGSPELVASLCSPetvpSDF-SQVLQSYTAAGYRVVALAGKPLP----- 772
Cdd:cd07541   362 EILQIFPFTSESKRMGIIVREEKTGEITFYMKGADVVMSKIVQY----NDWlEEECGNMAREGLRTLVVAKKKLSeeeyq 437
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  773 ---------IAPSLAAAQQLTR--DTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTVARACG 841
Cdd:cd07541   438 afekrynaaKLSIHDRDLKVAEvvESLERELELLCLTGVEDKLQEDVKPTLELLRNAGIKIWMLTGDKLETATCIAKSSK 517
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  842 MVGAQEHLAVIHA-THPEQgqpAALEFLPTESSavmngakatgyptvpepQSCHLALSGSTFAVLRKHFPKLLPKVLVQ- 919
Cdd:cd07541   518 LVSRGQYIHVFRKvTTREE---AHLELNNLRRK-----------------HDCALVIDGESLEVCLKYYEHEFIELACQl 577
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568932020  920 -ATVFARMAPEQKTELVCELQ-RLQYCVGMCGDGANDCGALKAADVGISLSQAE---ASVVSPFT 979
Cdd:cd07541   578 pAVVCCRCSPTQKAQIVRLIQkHTGKRTCAIGDGGNDVSMIQAADVGVGIEGKEgkqASLAADFS 642
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
379-965 1.48e-13

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 75.03  E-value: 1.48e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  379 GGEEEWVDSSELVPGDcLVLPQEGGVMPCDAALVAGECVVNESSLTGESTPVlktalPEGPKpycpethrrHTLFCGTLI 458
Cdd:cd07552   138 DGSIEDVPVSELKVGD-VVLVRAGEKIPADGTILEGESSVNESMVTGESKPV-----EKKPG---------DEVIGGSVN 202
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  459 LQARAYVGprvlavVTRTGFCTAKGGLVSSILHPRPISFKFYKHSMKFVAALSVLALLGTVYSIII-LYRNRVPvrEIVI 537
Cdd:cd07552   203 GNGTLEVK------VTKTGEDSYLSQVMELVAQAQASKSRAENLADKVAGWLFYIALGVGIIAFIIwLILGDLA--FALE 274
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  538 RAldlVTVVV---PPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFDKTGTLTEDGLDVMGVVPLKGqvl 614
Cdd:cd07552   275 RA---VTVLViacPHALGLAIPLVVARSTSIAAKNGLLIRNREALERARDIDVVLFDKTGTLTEGKFGVTDVITFDE--- 348
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  615 lplvpepchLPLGPLLRALATCHALSQlHdtpvgdPMDLKMVEstgwvleegpAAgsapgsqvlvvmrpppggpRQQEEP 694
Cdd:cd07552   349 ---------YDEDEILSLAAALEAGSE-H------PLAQAIVS----------AA-------------------KEKGIR 383
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  695 PVPVSVLCRFPFssalqrmdvvVTWPGATQPEAYVKGSPELVASLcspeTVPSDfSQVLQSYTAAGYRVVALagkplpia 774
Cdd:cd07552   384 PVEVENFENIPG----------VGVEGTVNGKRYQVVSPKYLKEL----GLKYD-EELVKRLAQQGNTVSFL-------- 440
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  775 pslaaaqqltrdTVERElsLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTVARACGMvgaqehlaviha 854
Cdd:cd07552   441 ------------IQDGE--VIGAIALGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQAVAEELGI------------ 494
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  855 thpeqgqpaaleflpTEssavmngakatgyptvpepqschlalsgstfavlrkhfpkllpkvlvqatVFARMAPEQKTEL 934
Cdd:cd07552   495 ---------------DE--------------------------------------------------YFAEVLPEDKAKK 509
                         570       580       590
                  ....*....|....*....|....*....|.
gi 568932020  935 VCELQRLQYCVGMCGDGANDCGALKAADVGI 965
Cdd:cd07552   510 VKELQAEGKKVAMVGDGVNDAPALAQADVGI 540
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
700-978 1.94e-13

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 75.11  E-value: 1.94e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   700 VLCRFPFSSALQRMDVVVTWPGAtQPEAYVKGSPELVASLCS--PETVPSDFSQVLQSYTAAGYRVVALAGKPLP----- 772
Cdd:TIGR01652  511 ILNVLEFNSDRKRMSVIVRNPDG-RIKLLCKGADTVIFKRLSsgGNQVNEETKEHLENYASEGLRTLCIAYRELSeeeye 589
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   773 --------IAPSLAAAQQLTR---DTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTVARACG 841
Cdd:TIGR01652  590 ewneeyneASTALTDREEKLDvvaESIEKDLILLGATAIEDKLQEGVPETIELLRQAGIKIWVLTGDKVETAINIGYSCR 669
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   842 MVGAQEHLAVIHATH--PEQGQPAALEFLPTESSAVMNGAKATG-YPTVPEPQSCHLALSGStfavLRKHFpkLLPKVLV 918
Cdd:TIGR01652  670 LLSRNMEQIVITSDSldATRSVEAAIKFGLEGTSEEFNNLGDSGnVALVIDGKSLGYALDEE----LEKEF--LQLALKC 743
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568932020   919 QATVFARMAPEQKTELVC----ELQRLQYCVgmcGDGANDCGALKAADVGISLSQAE---ASVVSPF 978
Cdd:TIGR01652  744 KAVICCRVSPSQKADVVRlvkkSTGKTTLAI---GDGANDVSMIQEADVGVGISGKEgmqAVMASDF 807
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
591-971 4.01e-13

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 74.13  E-value: 4.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  591 DKTGTLTEDgldVM--------GVVPLkgqvllplvpepchlplgpLLRALATCH-ALSQLHDTPVG------DPMDLKM 655
Cdd:cd02073   361 DKTGTLTEN---IMefkkcsinGVDYG-------------------FFLALALCHtVVPEKDDHPGQlvyqasSPDEAAL 418
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  656 VE---STGWVLEegpaaGSAPGSQVLVVMrpppGGPRQQEeppvpvsVLCRFPFSSALQRMDVVVTWPGAtQPEAYVKGS 732
Cdd:cd02073   419 VEaarDLGFVFL-----SRTPDTVTINAL----GEEEEYE-------ILHILEFNSDRKRMSVIVRDPDG-RILLYCKGA 481
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  733 PELVASLCSPETVP--SDFSQVLQSYTAAGYRVVALAGKPLP------IAPSLAAA--------QQLTR--DTVERELSL 794
Cdd:cd02073   482 DSVIFERLSPSSLElvEKTQEHLEDFASEGLRTLCLAYREISeeeyeeWNEKYDEAstalqnreELLDEvaEEIEKDLIL 561
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  795 LGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTVARACGMVgaqehlavihathPEQGQPAALeflptessa 874
Cdd:cd02073   562 LGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDKQETAINIGYSCRLL-------------SEDMENLAL--------- 619
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  875 VMNGAkatgyptvpepqSCHLALSGStfavLRKHFPKLLpkVLVQATVFARMAPEQKTELVCELQR-LQYCVGMCGDGAN 953
Cdd:cd02073   620 VIDGK------------TLTYALDPE----LERLFLELA--LKCKAVICCRVSPLQKALVVKLVKKsKKAVTLAIGDGAN 681
                         410
                  ....*....|....*...
gi 568932020  954 DCGALKAADVGISLSQAE 971
Cdd:cd02073   682 DVSMIQEAHVGVGISGQE 699
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
323-967 7.74e-12

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 69.60  E-value: 7.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  323 AFSIALWLAD------HYYWYALCIFLISAISICLALY-------KTRKQSLTLRDMvKLSVRVQVCRPGGEEEWVDSSE 389
Cdd:cd02078    35 IITTVLTFFPllfsggGPAGFNLAVSLWLWFTVLFANFaeaiaegRGKAQADSLRKT-KTETQAKRLRNDGKIEKVPATD 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  390 LVPGDcLVLPQEGGVMPCDAALVAGECVVNESSLTGESTPVLKTALPEgpkpycpethrRHTLFCGTLILQARAYVgpRV 469
Cdd:cd02078   114 LKKGD-IVLVEAGDIIPADGEVIEGVASVDESAITGESAPVIRESGGD-----------RSSVTGGTKVLSDRIKV--RI 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  470 LAVVTRTgFCTAKGGLV---SSILHPRPISFKFykhsmkFVAALSVLALLGTV--YSIIILYRNRVPVREIVirALdLVT 544
Cdd:cd02078   180 TANPGET-FLDRMIALVegaSRQKTPNEIALTI------LLVGLTLIFLIVVAtlPPFAEYSGAPVSVTVLV--AL-LVC 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  545 vVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFDKTGTLTEDGLDVMGVVPLKGqvllplVPEpchl 624
Cdd:cd02078   250 -LIPTTIGGLLSAIGIAGMDRLLRFNVIAKSGRAVEAAGDVDTLLLDKTGTITLGNRQATEFIPVGG------VDE---- 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  625 plgpllRALATCHALSQLHD-TPVGDPMdLKMVESTGWVLEEGPAAGSapgsqvlvvmrpppggprqqeeppvpvsvlcR 703
Cdd:cd02078   319 ------KELADAAQLASLADeTPEGRSI-VILAKQLGGTERDLDLSGA-------------------------------E 360
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  704 F-PFsSALQRMDVVVTwPGATQpeaYVKGS----PELVASLCSpeTVPSDFSQVLQsytaagyRVVALAGKPLPIApsla 778
Cdd:cd02078   361 FiPF-SAETRMSGVDL-PDGTE---IRKGAvdaiRKYVRSLGG--SIPEELEAIVE-------EISKQGGTPLVVA---- 422
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  779 aaqqltrdtveRELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTVARAcgmVGAQEHLAvihathpe 858
Cdd:cd02078   423 -----------EDDRVLGVIYLKDIIKPGIKERFAELRKMGIKTVMITGDNPLTAAAIAAE---AGVDDFLA-------- 480
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  859 qgqpaaleflptessavmngakatgyptvpepqschlalsgstfavlrkhfpkllpkvlvQATvfarmaPEQKTELVCEL 938
Cdd:cd02078   481 ------------------------------------------------------------EAK------PEDKLELIRKE 494
                         650       660
                  ....*....|....*....|....*....
gi 568932020  939 QRLQYCVGMCGDGANDCGALKAADVGISL 967
Cdd:cd02078   495 QAKGKLVAMTGDGTNDAPALAQADVGVAM 523
PLN03190 PLN03190
aminophospholipid translocase; Provisional
583-1028 7.90e-11

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 66.85  E-value: 7.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  583 GKLRLVCFDKTGTLTEDGLD-----VMGV-----------------VPLKGQVLLPLV-----PEPCHLP---------- 625
Cdd:PLN03190  451 GQIKYVFSDKTGTLTENKMEfqcasIWGVdysdgrtptqndhagysVEVDGKILRPKMkvkvdPQLLELSksgkdteeak 530
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  626 -LGPLLRALATCHALSQLHDTPVGDPmDLKMVESTGWVLEEGPAAGSAPGSQVLVVMRPPP------GGPRQQeeppvpV 698
Cdd:PLN03190  531 hVHDFFLALAACNTIVPIVVDDTSDP-TVKLMDYQGESPDEQALVYAAAAYGFMLIERTSGhividiHGERQR------F 603
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  699 SVLCRFPFSSALQRMDVVVTWPGATQpEAYVKGSPELVASL---CSPETVPSDFSQVLQSYTAAGYRVVALAGKPL---- 771
Cdd:PLN03190  604 NVLGLHEFDSDRKRMSVILGCPDKTV-KVFVKGADTSMFSVidrSLNMNVIRATEAHLHTYSSLGLRTLVVGMRELndse 682
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  772 ---------PIAPSLAAAQQLTR---DTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTVARA 839
Cdd:PLN03190  683 feqwhfsfeAASTALIGRAALLRkvaSNVENNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISIGYS 762
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  840 CGMVGAQEHLAVIHATHPEQGQPAALEFLPTESS--AVMNGAKATGYPTVPEPQSCHLALSGSTFA-VLRKHFPKLLPKV 916
Cdd:PLN03190  763 SKLLTNKMTQIIINSNSKESCRKSLEDALVMSKKltTVSGISQNTGGSSAAASDPVALIIDGTSLVyVLDSELEEQLFQL 842
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  917 LVQATVF--ARMAPEQKTELVCELQ-RLQYCVGMCGDGANDCGALKAADVGISLSQAE---ASVVSPFtsSMASIE-CVP 989
Cdd:PLN03190  843 ASKCSVVlcCRVAPLQKAGIVALVKnRTSDMTLAIGDGANDVSMIQMADVGVGISGQEgrqAVMASDF--AMGQFRfLVP 920
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 568932020  990 TVIREGRCsldtSFSVFKYMALYSLTQ---FISVLILYTINT 1028
Cdd:PLN03190  921 LLLVHGHW----NYQRMGYMILYNFYRnavFVLVLFWYVLFT 958
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
379-967 2.94e-10

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 64.35  E-value: 2.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  379 GGEEEWVDSSELVPGDCLVLpQEGGVMPCDAALVAGECVVNESSLTGESTPVLKTAlpeGPKpycpethrrhtLFCGTLI 458
Cdd:cd07546   106 NGERREVPADSLRPGDVIEV-APGGRLPADGELLSGFASFDESALTGESIPVEKAA---GDK-----------VFAGSIN 170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  459 lqarayvGPRVLAV-VTRTgfctAKGGLVSSILH--------PRPISFKFYKHSMKFVAALSVLALLGTVYSIIILYRnr 529
Cdd:cd07546   171 -------VDGVLRIrVTSA----PGDNAIDRILHlieeaeerRAPIERFIDRFSRWYTPAIMAVALLVIVVPPLLFGA-- 237
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  530 vPVREIVIRALDLVTVVVPPAL----PAAMTvCTLYAQSR--LRTQGIFCIHPLrinlgGKLRLVCFDKTGTLTEDGLDV 603
Cdd:cd07546   238 -DWQTWIYRGLALLLIGCPCALvistPAAIT-SGLAAAARrgALIKGGAALEQL-----GRVTTVAFDKTGTLTRGKPVV 310
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  604 MGVVPLKGQVLLPLVPEPCHLPLG---PLLRALaTCHAlsqlhdtpvgdpmdlkmvESTGWVLEEGPAAGSAPGSQVlvv 680
Cdd:cd07546   311 TDVVPLTGISEAELLALAAAVEMGsshPLAQAI-VARA------------------QAAGLTIPPAEEARALVGRGI--- 368
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  681 mrpppggprqqeeppvpvsvlcrfpfssalqrmdvvvtwpgatqpEAYVKGSPELvasLCSPETVPSDFSQVLQSytaag 760
Cdd:cd07546   369 ---------------------------------------------EGQVDGERVL---IGAPKFAADRGTLEVQG----- 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  761 yRVVAL--AGKplpiapslaaaqqlTRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTVAR 838
Cdd:cd07546   396 -RIAALeqAGK--------------TVVVVLANGRVLGLIALRDELRPDAAEAVAELNALGIKALMLTGDNPRAAAAIAA 460
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  839 ACGMvgaqehlavihathpeqgqpaaleflptessavmngakatgyptvpepqschlalsgstfavlrkhfpkllpkvlv 918
Cdd:cd07546   461 ELGL---------------------------------------------------------------------------- 464
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*....
gi 568932020  919 qaTVFARMAPEQKTELVCELQRLQyCVGMCGDGANDCGALKAADVGISL 967
Cdd:cd07546   465 --DFRAGLLPEDKVKAVRELAQHG-PVAMVGDGINDAPAMKAASIGIAM 510
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
325-612 6.15e-08

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 56.95  E-value: 6.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  325 SIALWLADHYYWYALCIFLISAISICLALYKTRKQSLTLRDMVKLSVRVQVCRPGGEEEWVDSSELVPGD-CLVLPQEgg 403
Cdd:cd07544    63 AIVATLLVGEYWASLIILLMLTGGEALEDYAQRRASRELTALLDRAPRIAHRLVGGQLEEVPVEEVTVGDrLLVRPGE-- 140
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  404 VMPCDAALVAGECVVNESSLTGESTPVLKTAlpegpkpycpethrrhtlfcGTLILQARAYVGPRVLAVVTRTGFCTAKG 483
Cdd:cd07544   141 VVPVDGEVVSGTATLDESSLTGESKPVSKRP--------------------GDRVMSGAVNGDSALTMVATKLAADSQYA 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  484 GLVSSILHPRPISFKFYKHSMKFVAALSVLALLGTVYSIIIlyrNRVPVreiviRALDLVTVVVPPALPAAMTVCTLYAQ 563
Cdd:cd07544   201 GIVRLVKEAQANPAPFVRLADRYAVPFTLLALAIAGVAWAV---SGDPV-----RFAAVLVVATPCPLILAAPVAIVSGM 272
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 568932020  564 SRLRTQGIFCIHPLRINLGGKLRLVCFDKTGTLTEDGLDVMGVVPLKGQ 612
Cdd:cd07544   273 SRSSRRGILVKDGGVLEKLARAKTVAFDKTGTLTYGQPKVVDVVPAPGV 321
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
379-842 7.32e-08

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 56.92  E-value: 7.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  379 GGEEEWVDSSELVPGDCL-VLPqeGGVMPCDAALVAGECVVNESSLTGESTPVLKTAlpeGPKpycpethrrhtlfcgtl 457
Cdd:PRK11033  250 DGEREEVAIADLRPGDVIeVAA--GGRLPADGKLLSPFASFDESALTGESIPVERAT---GEK----------------- 307
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  458 iLQARAYVGPRV--LAVVTRTGfctakGGLVSSILH--------PRPISFKFYKHSMKFVAALSVLALLGTVYSIIILYR 527
Cdd:PRK11033  308 -VPAGATSVDRLvtLEVLSEPG-----ASAIDRILHlieeaeerRAPIERFIDRFSRIYTPAIMLVALLVILVPPLLFAA 381
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  528 nrvPVREIVIRALDLVTVVVPPAL----PAAMTvCTLYAQSRlrtQGIFcihplrINLG------GKLRLVCFDKTGTLT 597
Cdd:PRK11033  382 ---PWQEWIYRGLTLLLIGCPCALvistPAAIT-SGLAAAAR---RGAL------IKGGaaleqlGRVTTVAFDKTGTLT 448
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  598 EDGLDVMGVVPLKGQVLLPLvpepchlplgpLLRALAtchalsqlhdtpvgdpmdlkmVEStgwvleegpaaGSA-PGSQ 676
Cdd:PRK11033  449 EGKPQVTDIHPATGISESEL-----------LALAAA---------------------VEQ-----------GSThPLAQ 485
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  677 VLVVMRpppggprQQEEPPVPvsvlcrfpfsSALQRMDVVvtwpgATQPEAYVKGspELVaSLCSPETVPSDFSQVLQsy 756
Cdd:PRK11033  486 AIVREA-------QVRGLAIP----------EAESQRALA-----GSGIEGQVNG--ERV-LICAPGKLPPLADAFAG-- 538
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  757 taagyRVVAL--AGKPLPIapslaaaqqltrdtVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAV 834
Cdd:PRK11033  539 -----QINELesAGKTVVL--------------VLRNDDVLGLIALQDTLRADARQAISELKALGIKGVMLTGDNPRAAA 599

                  ....*...
gi 568932020  835 TVARACGM 842
Cdd:PRK11033  600 AIAGELGI 607
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
380-1022 8.24e-08

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 56.37  E-value: 8.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  380 GEEEWVDSSELVPGDCLVLpQEGGVMPCDAALVAGECVVNESSLTGESTPVLKtalpegpkpycpetHRRHTLFCGTLIL 459
Cdd:cd07553   136 GSRIKTRADQIKSGDVYLV-ASGQRVPVDGKLLSEQASIDMSWLTGESLPRIV--------------ERGDKVPAGTSLE 200
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  460 QARAYVgpRVLAVVTRTGFCTAKGGLVSSILHPRPISFKFYKHSMKFVAALSVLALLGTVYSIIIlyrnrvPVREIVIRA 539
Cdd:cd07553   201 NQAFEI--RVEHSLAESWSGSILQKVEAQEARKTPRDLLADKIIHYFTVIALLIAVAGFGVWLAI------DLSIALKVF 272
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  540 LDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCIHPLRINLGGKLRLVCFDKTGTLTED-GLDVMGvvplkgqvllplV 618
Cdd:cd07553   273 TSVLIVACPCALALATPFTDEIALARLKKKGVLIKNASSLERLSRVRTIVFDKTGTLTRGkSSFVMV------------N 340
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  619 PEPCHLPLGPLLRAL--ATCHALSQLhdtpvgdpmdlkmvestgwVLEEGPAAGSApgsqvlvvmrpppggprqqeeppv 696
Cdd:cd07553   341 PEGIDRLALRAISAIeaHSRHPISRA-------------------IREHLMAKGLI------------------------ 377
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  697 pvsvlcRFPFSSALQrmdvvVTWPGAtqpEAYVKGSPELVASLCspetvpsdFSQVLQSYTAAGYrvvalagkplpiaps 776
Cdd:cd07553   378 ------KAGASELVE-----IVGKGV---SGNSSGSLWKLGSAP--------DACGIQESGVVIA--------------- 420
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  777 laaaqqltRDTVerelsLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQTAVTVAracgmvgaqehlavihath 856
Cdd:cd07553   421 --------RDGR-----QLLDLSFNDLLRPDSNREIEELKKGGLSIAILSGDNEEKVRLVG------------------- 468
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  857 peqgqpaaleflptessavmngakatgyptvpepqschlalsgstfavlrkhfpKLLPkvLVQATVFARMAPEQKTELVC 936
Cdd:cd07553   469 ------------------------------------------------------DSLG--LDPRQLFGNLSPEEKLAWIE 492
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  937 ELQrlQYCVGMCGDGANDCGALKAADVGISLS--QAEASVVSPFTSSMASIECVPTVIREGRCSLDTSFSVFKYMALYSL 1014
Cdd:cd07553   493 SHS--PENTLMVGDGANDALALASAFVGIAVAgeVGVSLEAADIYYAGNGIGGIRDLLTLSKQTIKAIKGLFAFSLLYNL 570

                  ....*...
gi 568932020 1015 TQFISVLI 1022
Cdd:cd07553   571 VAIGLALS 578
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
335-842 1.18e-06

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 52.78  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  335 YWYALCIFLISAISICLALYKTRKQSLTLRDmVKLSVRVQVCRPGGEEEWVDSSELVPGDcLVLPQEGGVMPCDAALVAG 414
Cdd:PRK14010   69 FIILLLTLVFANFSEALAEGRGKAQANALRQ-TQTEMKARRIKQDGSYEMIDASDLKKGH-IVRVATGEQIPNDGKVIKG 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  415 ECVVNESSLTGESTPVLKTALPEGPKPYCPETHRRHTLFCGTLILQARAYVGPRVLAVVTRTGFCTAKGGLVSSILHPRP 494
Cdd:PRK14010  147 LATVDESAITGESAPVIKESGGDFDNVIGGTSVASDWLEVEITSEPGHSFLDKMIGLVEGATRKKTPNEIALFTLLMTLT 226
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  495 ISFkfykhsmkfvaalsvLALLGTVYSIIILYRNRVPVREIVIraldLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFCI 574
Cdd:PRK14010  227 IIF---------------LVVILTMYPLAKFLNFNLSIAMLIA----LAVCLIPTTIGGLLSAIGIAGMDRVTQFNILAK 287
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  575 HPLRINLGGKLRLVCFDKTGTLTEDGLDVMGVVPLKGQVLLPLVpepchlplgpllRALATChalSQLHDTPvgdpmdlk 654
Cdd:PRK14010  288 SGRSVETCGDVNVLILDKTGTITYGNRMADAFIPVKSSSFERLV------------KAAYES---SIADDTP-------- 344
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  655 mvestgwvleegpaagsaPGSQVLVVMRpppggprqQEEPPVPVSVLCRFPFSsALQRMDVVvtwpGATQPEAYvKGSPE 734
Cdd:PRK14010  345 ------------------EGRSIVKLAY--------KQHIDLPQEVGEYIPFT-AETRMSGV----KFTTREVY-KGAPN 392
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  735 LVASLCSPET--VPSDFSQVLQSYTAAGyrvvalaGKPLPIapslaaaqqltrdtVERELsLLGLLVMRNLLKPQTAPVI 812
Cdd:PRK14010  393 SMVKRVKEAGghIPVDLDALVKGVSKKG-------GTPLVV--------------LEDNE-ILGVIYLKDVIKDGLVERF 450
                         490       500       510
                  ....*....|....*....|....*....|
gi 568932020  813 QTLRKTGIRTVMVTGDNLQTAVTVARACGM 842
Cdd:PRK14010  451 RELREMGIETVMCTGDNELTAATIAKEAGV 480
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
364-905 2.42e-06

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 51.59  E-value: 2.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  364 RDMVKLSVR-VQVCRPGGEEEWVDSSELVPGDCLVLPQeGGVMPCDAALVAGECVVNESSLTGESTPVlkTALPEGPkpy 442
Cdd:cd02092   118 EELAALEARgAQRLQADGSREYVPVAEIRPGDRVLVAA-GERIPVDGTVVSGTSELDRSLLTGESAPV--TVAPGDL--- 191
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  443 cpethrrhtLFCGTLILQARAYVgpRVLAVVTRTgFCTAKGGLVSSILHPRPISFKFY-KHSMKFVAALSVLALLGTVYS 521
Cdd:cd02092   192 ---------VQAGAMNLSGPLRL--RATAAGDDT-LLAEIARLMEAAEQGRSRYVRLAdRAARLYAPVVHLLALLTFVGW 259
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  522 IIIlyrnRVPVREIVIRALDLVTVVVPPALPAAMTVCTLYAQSRLRTQGIFcihplrINLGGKL-RL-----VCFDKTGT 595
Cdd:cd02092   260 VAA----GGDWRHALLIAVAVLIITCPCALGLAVPAVQVVASGRLFRRGVL------VKDGTALeRLaevdtVVFDKTGT 329
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  596 LTedgldvMGVVPLKGQVLLPlvPEPCHLpLGPLlrALATCHALSQ--LHDTPVGDPMDLKMVESTGWVLEegpaaGSAP 673
Cdd:cd02092   330 LT------LGSPRLVGAHAIS--ADLLAL-AAAL--AQASRHPLSRalAAAAGARPVELDDAREVPGRGVE-----GRID 393
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  674 GSQVLVVMRPPPGGPRQQEEPP-----VPVSVLCRFPFSSALQrmdvvvtwPGATqpeayvkgspelvaslcspetvpsd 748
Cdd:cd02092   394 GARVRLGRPAWLGASAGVSTASelalsKGGEEAARFPFEDRPR--------PDAR------------------------- 440
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  749 fsQVLQSYTAAGYRVVALAGKPLPIAPSLAAAqqltrdtverelslLGLLVMRNLLKP-QTAPVIQTLRKTGIRTVMVtG 827
Cdd:cd02092   441 --EAISALRALGLSVEILSGDREPAVRALARA--------------LGIEDWRAGLTPaEKVARIEELKAQGRRVLMV-G 503
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  828 DNLQTAVTVARAcgmvgaqeHLAVIHATHPEQGQPAA-LEFLPTESSAVM---------------NGAKATGYP--TVP- 888
Cdd:cd02092   504 DGLNDAPALAAA--------HVSMAPASAVDASRSAAdIVFLGDSLAPVPeaieiarrarrlirqNFALAIGYNviAVPl 575
                         570       580
                  ....*....|....*....|...
gi 568932020  889 ------EPQSCHLALSGSTFAVL 905
Cdd:cd02092   576 aiagyvTPLIAALAMSTSSIVVV 598
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
704-741 2.16e-04

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 41.44  E-value: 2.16e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568932020   704 FPFSSALQRMDVVVTWPGATQPEAYVKGSPELVASLCS 741
Cdd:pfam13246   52 IPFNSDRKRMSTVHKLPDDGKYRLFVKGAPEIILDRCT 89
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
758-850 4.61e-04

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 42.57  E-value: 4.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020   758 AAGYRVVALAGKP------LPIAPSLAAAQQLTRDTVERELSLLGLLVMRNLLKPQTAPVIQTLRKTGIRTVMVTGDNLQ 831
Cdd:pfam00702   47 VEDFTARLLLGKRdwleelDILRGLVETLEAEGLTVVLVELLGVIALADELKLYPGAAEALKALKERGIKVAILTGDNPE 126
                           90
                   ....*....|....*....
gi 568932020   832 TAVTVARACGMVGAQEHLA 850
Cdd:pfam00702  127 AAEALLRLLGLDDYFDVVI 145
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
271-343 7.00e-04

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 39.49  E-value: 7.00e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568932020    271 TCDDVHCS-SSGLSLQDQATRKTIYGPNVISIPVK-SYLQLLADEALNPyygfqaFSIALWLADhyywyALCIFL 343
Cdd:smart00831   12 VLERLQTDlEKGLSSEEAARRLERYGPNELPPPKKtSPLLRFLRQFHNP------LIYILLAAA-----VLSALL 75
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
379-611 1.66e-03

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 42.61  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  379 GGEEEWVDSSELVPGDcLVLPQEGGVMPCDAALVAGECVVNESSLTGESTPVLKTalpEGpkpycpethrrHTLFCGTLI 458
Cdd:cd07548   116 NNELKDVKPEEVQIGD-IIVVKPGEKIPLDGVVLKGESFLDTSALTGESVPVEVK---EG-----------SSVLAGFIN 180
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  459 LQArayvgprVLAV-VTRTGFCTAkgglVSSILH------------PRPISfKFYKHSMKFVAALSVlaLLGTVYSIIIL 525
Cdd:cd07548   181 LNG-------VLEIkVTKPFKDSA----VAKILElvenasarkaptEKFIT-KFARYYTPIVVFLAL--LLAVIPPLFSP 246
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932020  526 YRNRvpvREIVIRALDLVTVVVPPALpaAMTVCTLY-----AQSRlrtQGIFCIHPLRINLGGKLRLVCFDKTGTLTEDG 600
Cdd:cd07548   247 DGSF---SDWIYRALVFLVISCPCAL--VISIPLGYfggigAASR---KGILIKGSNYLEALSQVKTVVFDKTGTLTKGV 318
                         250
                  ....*....|.
gi 568932020  601 LDVMGVVPLKG 611
Cdd:cd07548   319 FKVTEIVPAPG 329
copA PRK10671
copper-exporting P-type ATPase CopA;
922-967 2.16e-03

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 42.42  E-value: 2.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 568932020  922 VFARMAPEQKTELVCELQRLQYCVGMCGDGANDCGALKAADVGISL 967
Cdd:PRK10671  692 VIAGVLPDGKAEAIKRLQSQGRQVAMVGDGINDAPALAQADVGIAM 737
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
277-331 3.39e-03

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 37.15  E-value: 3.39e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568932020   277 CSSSGLSLQDQATRKTIYGPNVIS-IPVKSYLQLLADEALNPyygfqaFSIALWLA 331
Cdd:pfam00690   16 DLEKGLTEAEAEKRLKKYGPNELPeKKPKSLWKLFLRQFKDP------LIIILLIA 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH