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Conserved domains on  [gi|568930424|ref|XP_006538534|]
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protein RCC2 isoform X1 [Mus musculus]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 11474102)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Arabidopsis UVR8 (UV RESISTANCE LOCUS 8), which plays an important role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway.

Gene Ontology:  GO:0003682|GO:0005085
PubMed:  9510255|18442486

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 149-500 1.91e-50

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 175.94  E-value: 1.91e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930424 149 RTVVSGScaAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALSHeaIVLAACGRNHTLALTDTGSVFAFGENK 228
Cdd:COG5184    1 TQVAAGG--SHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930424 229 MGQLGLGNqTDAVPSPAQIMYNGqPITKMACGAEFSMLMDCKGNLYSFGCPEYGQLGhnsDGKFIARaqrieydceLVPR 308
Cdd:COG5184   77 YGQLGDGT-TTDRTTPVKVPGLT-GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLG---DGTTTNR---------LTPV 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930424 309 RVAIFIEKtkdgqilpvpnvvVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDfpgrGATQIY 388
Cdd:COG5184  143 QVDAGLSG-------------VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLS----GVVAVA 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930424 389 AGYTCSFAVSEVGGLFFWGA---------TNTSREStmyPKAVQDLCGWriRSLACG-KSSIIVAADESTISWGpSPTFG 458
Cdd:COG5184  206 AGGDHSCALKSDGTVWCWGSnssgqlgdgTTTDRAT---PVQVAGLTGV--VAIAAGgSHTCALKSDGTVWCWG-DNSYG 279

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 568930424 459 ELGYGDhkPKSSTAAQEVKTLDGIfsEQVAMGYSHSLVIARD 500
Cdd:COG5184  280 QLGDGT--TTDRSTPVKVPGLSGV--VAVAAGSSHTCALLTD 317
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 149-500 1.91e-50

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 175.94  E-value: 1.91e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930424 149 RTVVSGScaAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALSHeaIVLAACGRNHTLALTDTGSVFAFGENK 228
Cdd:COG5184    1 TQVAAGG--SHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930424 229 MGQLGLGNqTDAVPSPAQIMYNGqPITKMACGAEFSMLMDCKGNLYSFGCPEYGQLGhnsDGKFIARaqrieydceLVPR 308
Cdd:COG5184   77 YGQLGDGT-TTDRTTPVKVPGLT-GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLG---DGTTTNR---------LTPV 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930424 309 RVAIFIEKtkdgqilpvpnvvVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDfpgrGATQIY 388
Cdd:COG5184  143 QVDAGLSG-------------VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLS----GVVAVA 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930424 389 AGYTCSFAVSEVGGLFFWGA---------TNTSREStmyPKAVQDLCGWriRSLACG-KSSIIVAADESTISWGpSPTFG 458
Cdd:COG5184  206 AGGDHSCALKSDGTVWCWGSnssgqlgdgTTTDRAT---PVQVAGLTGV--VAIAAGgSHTCALKSDGTVWCWG-DNSYG 279

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 568930424 459 ELGYGDhkPKSSTAAQEVKTLDGIfsEQVAMGYSHSLVIARD 500
Cdd:COG5184  280 QLGDGT--TTDRSTPVKVPGLSGV--VAVAAGSSHTCALLTD 317
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
166-215 1.82e-16

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 73.32  E-value: 1.82e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 568930424  166 EGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALSHEAIVLAACGRNHTLAL 215
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 149-500 1.91e-50

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 175.94  E-value: 1.91e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930424 149 RTVVSGScaAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALSHeaIVLAACGRNHTLALTDTGSVFAFGENK 228
Cdd:COG5184    1 TQVAAGG--SHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930424 229 MGQLGLGNqTDAVPSPAQIMYNGqPITKMACGAEFSMLMDCKGNLYSFGCPEYGQLGhnsDGKFIARaqrieydceLVPR 308
Cdd:COG5184   77 YGQLGDGT-TTDRTTPVKVPGLT-GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLG---DGTTTNR---------LTPV 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930424 309 RVAIFIEKtkdgqilpvpnvvVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDfpgrGATQIY 388
Cdd:COG5184  143 QVDAGLSG-------------VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLS----GVVAVA 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930424 389 AGYTCSFAVSEVGGLFFWGA---------TNTSREStmyPKAVQDLCGWriRSLACG-KSSIIVAADESTISWGpSPTFG 458
Cdd:COG5184  206 AGGDHSCALKSDGTVWCWGSnssgqlgdgTTTDRAT---PVQVAGLTGV--VAIAAGgSHTCALKSDGTVWCWG-DNSYG 279

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 568930424 459 ELGYGDhkPKSSTAAQEVKTLDGIfsEQVAMGYSHSLVIARD 500
Cdd:COG5184  280 QLGDGT--TTDRSTPVKVPGLSGV--VAVAAGSSHTCALLTD 317
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 148-407 4.44e-41

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 150.90  E-value: 4.44e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930424 148 VRTVVSGscAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALSHEAIVLAAcGRNHTLALTDTGSVFAFGEN 227
Cdd:COG5184  100 VVAVAAG--YYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSGVVAIAA-GGYHTCALKSDGTVWCWGAN 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930424 228 KMGQLGLGNQTDaVPSPAQIMyNGQPITKMACGAEFSMLMDCKGNLYSFGCPEYGQLGhnsDGKFIARAqrieydcelVP 307
Cdd:COG5184  177 SYGQLGDGTTTD-RPTPVQVG-GLSGVVAVAAGGDHSCALKSDGTVWCWGSNSSGQLG---DGTTTDRA---------TP 242

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930424 308 RRVAifiektkdgqilpvPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDfpgrGATQI 387
Cdd:COG5184  243 VQVA--------------GLTGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLS----GVVAV 304

                        250       260
                 ....*....|....*....|
gi 568930424 388 YAGYTCSFAVSEVGGLFFWG 407
Cdd:COG5184  305 AAGSSHTCALLTDGTVWCWG 324
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 148-371 6.96e-35

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 133.95  E-value: 6.96e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930424 148 VRTVVSGScaAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALSHeaIVLAACGRNHTLALTDTGSVFAFGEN 227
Cdd:COG5184  151 VVAIAAGG--YHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSG--VVAVAAGGDHSCALKSDGTVWCWGSN 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930424 228 KMGQLGLGNQTDaVPSPAQIMyNGQPITKMACGAEFSMLMDCKGNLYSFGCPEYGQLGHNSdgkfiaRAQRieydceLVP 307
Cdd:COG5184  227 SSGQLGDGTTTD-RATPVQVA-GLTGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGT------TTDR------STP 292

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568930424 308 RRVAifiektkdgqilPVPNVVvrDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVP 371
Cdd:COG5184  293 VKVP------------GLSGVV--AVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTP 342
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
166-215 1.82e-16

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 73.32  E-value: 1.82e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 568930424  166 EGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALSHEAIVLAACGRNHTLAL 215
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
348-397 1.10e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 54.06  E-value: 1.10e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 568930424  348 RVFSWGFGGYGRLGHAEQKDEMVPRLVKLfdFPGRGATQIYAGYTCSFAV 397
Cdd:pfam00415   3 RVYTWGRNDYGQLGLGTTENVLVPQKVEG--LSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
219-267 2.06e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 53.29  E-value: 2.06e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 568930424  219 GSVFAFGENKMGQLGLGNQTDaVPSPAQIMY-NGQPITKMACGAEFSMLM 267
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTEN-VLVPQKVEGlSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
270-343 1.09e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 50.98  E-value: 1.09e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568930424  270 KGNLYSFGCPEYGQLGHNSDgkfiaraqrieyDCELVPRRVAIFiektkdgqilpvPNVVVRDVACGANHTLVL 343
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTT------------ENVLVPQKVEGL------------SGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
202-231 2.29e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 47.03  E-value: 2.29e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 568930424  202 IVLAACGRNHTLALTDTGSVFAFGENKMGQ 231
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
330-359 7.40e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 45.49  E-value: 7.40e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 568930424  330 VRDVACGANHTLVLDSQKRVFSWGFGGYGR 359
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
148-179 9.64e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.41  E-value: 9.64e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 568930424  148 VRTVVSGScaAHSLLITTEGKLWSWGRNEKGQ 179
Cdd:pfam13540   1 VVSVAAGD--NHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
254-283 1.62e-03

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 35.86  E-value: 1.62e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 568930424  254 ITKMACGAEFSMLMDCKGNLYSFGCPEYGQ 283
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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