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Conserved domains on  [gi|568952430|ref|XP_006536286|]
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NAD-dependent protein deacetylase sirtuin-3 isoform X2 [Mus musculus]

Protein Classification

SIR2 family protein( domain architecture ID 1222)

SIR2 family protein similar to NAD-dependent deacetylase that catalyzes NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose

PubMed:  7498786

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SIR2 super family cl00195
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ...
 1-177 2.27e-89

SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.


The actual alignment was detected with superfamily member cd01408:

Pssm-ID: 444738  Cd Length: 235  Bit Score: 262.18  E-value: 2.27e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430   1 MVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFMLAKELYPGHYRPNVTHYFLRLLHDKELL 80
Cdd:cd01408    6 LVGAGISTSAGIPDFRSPGTGLYANLARYNLPYPEAMFDISYFRKNPRPFYALAKELYPGQFKPSVAHYFIKLLEDKGLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430  81 LRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSFPGEDIW--------------------------------- 127
Cdd:cd01408   86 LRNYTQNIDTLERVAGVPDDRIIEAHGSFATAHCIKCKHKYPGDWMRedifnqevpkcprcgglvkpdivffgeslpsrf 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568952430 128 ----------------------VEPFASLSEAVQKSVPRLLINRDLVGPfvLSPRRKDVVQLGDVVHGVERL 177
Cdd:cd01408  166 fshmeedkeeadllivigtslkVAPFASLPSRVPSEVPRVLINREPVGH--LGKRPFDVALLGDCDDGVREL 235
 
Name Accession Description Interval E-value
SIRT1 cd01408
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and ...
 1-177 2.27e-89

SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The nuclear SIRT1 has been shown to target the p53 tumor suppressor protein for deacetylation to suppress DNA damage, and the cytoplasmic SIRT2 homolog has been shown to target alpha-tubulin for deacetylation for the maintenance of cell integrity.


Pssm-ID: 238699  Cd Length: 235  Bit Score: 262.18  E-value: 2.27e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430   1 MVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFMLAKELYPGHYRPNVTHYFLRLLHDKELL 80
Cdd:cd01408    6 LVGAGISTSAGIPDFRSPGTGLYANLARYNLPYPEAMFDISYFRKNPRPFYALAKELYPGQFKPSVAHYFIKLLEDKGLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430  81 LRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSFPGEDIW--------------------------------- 127
Cdd:cd01408   86 LRNYTQNIDTLERVAGVPDDRIIEAHGSFATAHCIKCKHKYPGDWMRedifnqevpkcprcgglvkpdivffgeslpsrf 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568952430 128 ----------------------VEPFASLSEAVQKSVPRLLINRDLVGPfvLSPRRKDVVQLGDVVHGVERL 177
Cdd:cd01408  166 fshmeedkeeadllivigtslkVAPFASLPSRVPSEVPRVLINREPVGH--LGKRPFDVALLGDCDDGVREL 235
SIR2 pfam02146
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ...
 3-126 3.32e-48

Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i


Pssm-ID: 426621  Cd Length: 179  Bit Score: 155.49  E-value: 3.32e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430    3 GAGISTPSGIPDFRSPGsGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFMLAKELYPGHYRPNVTHYFLRLLHDKELLLR 82
Cdd:pfam02146   1 GAGISTESGIPDFRSDD-GLYAKLAPEELASPEAFFSNPELVWDPEPFYNIARELLPGEAQPNPAHYFIAKLEDKGKLLR 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 568952430   83 LYTQNIDGLERASGIpaSKLVEAHGTFVTATCTVCRRSFPGEDI 126
Cdd:pfam02146  80 LITQNIDGLHERAGS--KKVVELHGSFAKARCVSCHQKYTGETL 121
PTZ00410 PTZ00410
NAD-dependent SIR2; Provisional
 1-153 1.91e-44

NAD-dependent SIR2; Provisional


Pssm-ID: 185600  Cd Length: 349  Bit Score: 150.79  E-value: 1.91e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430   1 MVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFMLAKE--LYPGHYRPNVTHYFLRLLHDKE 78
Cdd:PTZ00410  35 MVGAGISVAAGIPDFRSPHTGIYAKLGKYNLNSPTDAFSLTLLREKPEVFYSIAREmdLWPGHFQPTAVHHFIRLLADEG 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430  79 LLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSFP------------------------------------ 122
Cdd:PTZ00410 115 RLLRCCTQNIDGLERAAGVPPSLLVEAHGSFSAASCIECHTPYDieqaylearsgkvphcstcggivkpdvvffgenlpd 194

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 568952430 123 ------------------GEDIWVEPFASLSEAVQKSVPRLLINRDLVG 153
Cdd:PTZ00410 195 affnvhhdipeaellliiGTSLQVHPFALLACVVPKDVPRVLFNLERVG 243
SIR2 COG0846
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ...
 3-126 1.28e-26

NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440607  Cd Length: 243  Bit Score: 101.78  E-value: 1.28e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430   3 GAGISTPSGIPDFRSPGsGLYSnlqQYDipyPEAIFELGFFFHNPKPF--FMLAKELYPGHYRPNVTHYFLRLLHDKELL 80
Cdd:COG0846   22 GAGISAESGIPDFRGPD-GLWE---KYD---PEEVASPEAFRRDPELVwaFYNERRRLLRDAEPNAAHRALAELEKAGKL 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 568952430  81 LRLYTQNIDGL-ERAsGipASKLVEAHGTFVTATCTVCRRSFPGEDI 126
Cdd:COG0846   95 VFVITQNVDGLhQRA-G--SKNVIELHGSLHRLRCTKCGKRYDLEDV 138
 
Name Accession Description Interval E-value
SIRT1 cd01408
SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and ...
 1-177 2.27e-89

SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The nuclear SIRT1 has been shown to target the p53 tumor suppressor protein for deacetylation to suppress DNA damage, and the cytoplasmic SIRT2 homolog has been shown to target alpha-tubulin for deacetylation for the maintenance of cell integrity.


Pssm-ID: 238699  Cd Length: 235  Bit Score: 262.18  E-value: 2.27e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430   1 MVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFMLAKELYPGHYRPNVTHYFLRLLHDKELL 80
Cdd:cd01408    6 LVGAGISTSAGIPDFRSPGTGLYANLARYNLPYPEAMFDISYFRKNPRPFYALAKELYPGQFKPSVAHYFIKLLEDKGLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430  81 LRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSFPGEDIW--------------------------------- 127
Cdd:cd01408   86 LRNYTQNIDTLERVAGVPDDRIIEAHGSFATAHCIKCKHKYPGDWMRedifnqevpkcprcgglvkpdivffgeslpsrf 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568952430 128 ----------------------VEPFASLSEAVQKSVPRLLINRDLVGPfvLSPRRKDVVQLGDVVHGVERL 177
Cdd:cd01408  166 fshmeedkeeadllivigtslkVAPFASLPSRVPSEVPRVLINREPVGH--LGKRPFDVALLGDCDDGVREL 235
SIR2-fam cd01407
SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze ...
 1-127 6.18e-49

SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer.


Pssm-ID: 238698  Cd Length: 218  Bit Score: 158.50  E-value: 6.18e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430   1 MVGAGISTPSGIPDFRSPGsGLYSNLQQYDIPypeaiFELGFFFHNPKPFFMLAKELY-PGHYRPNVTHYFLRLLHDKEL 79
Cdd:cd01407    6 LTGAGISTESGIPDFRSPG-GLWARLDPEELA-----FSPEAFRRDPELFWGFYRERRyPLNAQPNPAHRALAELERKGK 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 568952430  80 LLRLYTQNIDGLERASGIPasKLVEAHGTFVTATCTVCRRSFPGEDIW 127
Cdd:cd01407   80 LKRVITQNVDGLHQRAGSP--KVIELHGSLFRVRCTKCGKEYPRDELQ 125
SIR2 pfam02146
Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, ...
 3-126 3.32e-48

Sir2 family; This region is characteriztic of Silent information regulator 2 (Sir2) proteins, or sirtuins. These are protein deacetylases that depend on nicotine adenine dinucleotide (NAD). They are found in many subcellular locations, including the nucleus, cytoplasm and mitochondria. Eukaryotic forms play in important role in the regulation of transcriptional repression. Moreover, they are involved in microtubule organization and DNA damage repair processes.i


Pssm-ID: 426621  Cd Length: 179  Bit Score: 155.49  E-value: 3.32e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430    3 GAGISTPSGIPDFRSPGsGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFMLAKELYPGHYRPNVTHYFLRLLHDKELLLR 82
Cdd:pfam02146   1 GAGISTESGIPDFRSDD-GLYAKLAPEELASPEAFFSNPELVWDPEPFYNIARELLPGEAQPNPAHYFIAKLEDKGKLLR 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 568952430   83 LYTQNIDGLERASGIpaSKLVEAHGTFVTATCTVCRRSFPGEDI 126
Cdd:pfam02146  80 LITQNIDGLHERAGS--KKVVELHGSFAKARCVSCHQKYTGETL 121
SIR2 cd00296
SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which ...
 1-127 1.46e-44

SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, producing nicotinamide and the novel metabolite O-acetyl-ADP-ribose. Sir2 proteins, also known as sirtuins, are found in all eukaryotes and many archaea and prokaryotes and have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The most-studied function, gene silencing, involves the inactivation of chromosome domains containing key regulatory genes by packaging them into a specialized chromatin structure that is inaccessible to DNA-binding proteins. The oligomerization state of Sir2 appears to be organism-dependent, sometimes occurring as a monomer and sometimes as a multimer. Also included in this superfamily is a group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines.


Pssm-ID: 238184 [Multi-domain]  Cd Length: 222  Bit Score: 147.49  E-value: 1.46e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430   1 MVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAifelgFFFHNPKPFFMLAKELY--PGHYRPNVTHYFLRLLHDKE 78
Cdd:cd00296    6 FTGAGISTESGIPDFRGLGTGLWTRLDPEELAFSPE-----AFRRDPELFWLFYKERRytPLDAKPNPAHRALAELERKG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 568952430  79 LLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSFPGEDIW 127
Cdd:cd00296   81 KLKRIITQNVDGLHERAGSRRNRVIELHGSLDRVRCTSCGKEYPRDEVL 129
PTZ00410 PTZ00410
NAD-dependent SIR2; Provisional
 1-153 1.91e-44

NAD-dependent SIR2; Provisional


Pssm-ID: 185600  Cd Length: 349  Bit Score: 150.79  E-value: 1.91e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430   1 MVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFMLAKE--LYPGHYRPNVTHYFLRLLHDKE 78
Cdd:PTZ00410  35 MVGAGISVAAGIPDFRSPHTGIYAKLGKYNLNSPTDAFSLTLLREKPEVFYSIAREmdLWPGHFQPTAVHHFIRLLADEG 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430  79 LLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSFP------------------------------------ 122
Cdd:PTZ00410 115 RLLRCCTQNIDGLERAAGVPPSLLVEAHGSFSAASCIECHTPYDieqaylearsgkvphcstcggivkpdvvffgenlpd 194

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 568952430 123 ------------------GEDIWVEPFASLSEAVQKSVPRLLINRDLVG 153
Cdd:PTZ00410 195 affnvhhdipeaellliiGTSLQVHPFALLACVVPKDVPRVLFNLERVG 243
SIR2_Af2 cd01413
SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, ...
 3-129 9.74e-31

SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. The Sir2 homolog from the archaea Sulfolobus solftaricus deacetylates the non-specific DNA protein Alba to mediate transcription repression.


Pssm-ID: 238704  Cd Length: 222  Bit Score: 112.08  E-value: 9.74e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430   3 GAGISTPSGIPDFRSPGsGLYsnlQQYDipyPEAIFELGFFFHNPKPFFMLAKE-LYPGH-YRPNVTHYFLRLLHDKELL 80
Cdd:cd01413   12 GAGISTESGIPDFRSPD-GLW---KKYD---PEEVASIDYFYRNPEEFWRFYKEiILGLLeAQPNKAHYFLAELEKQGII 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 568952430  81 LRLYTQNIDGLERASGipaSKLV-EAHGTFVTATCTVCRRSFPGEDIWVE 129
Cdd:cd01413   85 KAIITQNIDGLHQRAG---SKNViELHGTLQTAYCVNCGSKYDLEEVKYA 131
PRK00481 PRK00481
NAD-dependent deacetylase; Provisional
 3-126 3.08e-27

NAD-dependent deacetylase; Provisional


Pssm-ID: 234777  Cd Length: 242  Bit Score: 103.34  E-value: 3.08e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430   3 GAGISTPSGIPDFRSPGsGLYSNLqqydipYPEAIFELGFFFHNPKPFF----MLAKELYpgHYRPNVTHYFLRLLHDKE 78
Cdd:PRK00481  21 GAGISAESGIPDFRSAN-GLWEEH------RPEDVASPEGFARDPELVWkfynERRRQLL--DAKPNAAHRALAELEKLG 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 568952430  79 LLLRLYTQNIDGLERASGipASKLVEAHGTFVTATCTVCRRSFPGEDI 126
Cdd:PRK00481  92 KLVTVITQNIDGLHERAG--SKNVIELHGSLLRARCTKCGQTYDLDEY 137
PRK14138 PRK14138
NAD-dependent deacetylase; Provisional
 1-126 3.28e-27

NAD-dependent deacetylase; Provisional


Pssm-ID: 172627 [Multi-domain]  Cd Length: 244  Bit Score: 103.36  E-value: 3.28e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430   1 MVGAGISTPSGIPDFRSPgSGLYSNlqqydipYPEAIFELGFFFHNPKPFFMLAKE-LYP-GHYRPNVTHYFLRLLHDKE 78
Cdd:PRK14138  17 LTGAGISTPSGIPDFRGP-QGIYKK-------YPQNVFDIDFFYSHPEEFYRFAKEgIFPmLEAKPNLAHVLLAKLEEKG 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 568952430  79 LLLRLYTQNIDGLERASGipASKLVEAHGTFVTATCTVCRRSFPGEDI 126
Cdd:PRK14138  89 LIEAVITQNIDRLHQKAG--SKKVIELHGNVEEYYCVRCGKRYTVEDV 134
SIR2 COG0846
NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein ...
 3-126 1.28e-26

NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440607  Cd Length: 243  Bit Score: 101.78  E-value: 1.28e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430   3 GAGISTPSGIPDFRSPGsGLYSnlqQYDipyPEAIFELGFFFHNPKPF--FMLAKELYPGHYRPNVTHYFLRLLHDKELL 80
Cdd:COG0846   22 GAGISAESGIPDFRGPD-GLWE---KYD---PEEVASPEAFRRDPELVwaFYNERRRLLRDAEPNAAHRALAELEKAGKL 94

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 568952430  81 LRLYTQNIDGL-ERAsGipASKLVEAHGTFVTATCTVCRRSFPGEDI 126
Cdd:COG0846   95 VFVITQNVDGLhQRA-G--SKNVIELHGSLHRLRCTKCGKRYDLEDV 138
SIR2H cd01411
SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species ...
 1-125 3.58e-23

SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238702  Cd Length: 225  Bit Score: 92.43  E-value: 3.58e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430   1 MVGAGISTPSGIPDFRSPGsGLYSNLQQYDipyPEAIFELGFFFHNPKPF--FMLAKELYPGhYRPNVTHYFLRLLhDKE 78
Cdd:cd01411   14 FTGAGVSTASGIPDYRSKN-GLYNEIYKYS---PEYLLSHDFLEREPEKFyqFVKENLYFPD-AKPNIIHQKMAEL-EKM 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 568952430  79 LLLRLYTQNIDGLERASGipASKLVEAHGTFVTATCTVCRRSFPGED 125
Cdd:cd01411   88 GLKAVITQNIDGLHQKAG--SKNVVEFHGSLYRIYCTVCGKTVDWEE 132
SIRT7 cd01410
SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, ...
 3-126 2.86e-21

SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238701  Cd Length: 206  Bit Score: 86.97  E-value: 2.86e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430   3 GAGISTPSGIPDFRSPGsGLYSNLQQ------YDIPYPEAifelgfffhnpkpffmlakelypghyRPNVTHYFLRLLHD 76
Cdd:cd01410    8 GAGISTSAGIPDFRGPN-GVWTLLPEdkgrrrFSWRFRRA--------------------------EPTLTHMALVELER 60

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 568952430  77 KELLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSFPGEDI 126
Cdd:cd01410   61 AGLLKFVISQNVDGLHLRSGLPREKLSELHGNMFIEVCKSCGPEYVRDDV 110
SIRT5_Af1_CobB cd01412
SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human ...
 2-130 4.53e-15

SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span. CobB is a bacterial sirtuin that deacetylates acetyl-CoA synthetase at an active site lysine to stimulate its enzymatic activity.


Pssm-ID: 238703  Cd Length: 224  Bit Score: 70.70  E-value: 4.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430   2 VGAGISTPSGIPDFRSPGsGLYSNLQQYDIPYPEAifelgfFFHNPKpffmLAKELYpgHYR--------PNVTHYFLRL 73
Cdd:cd01412    7 TGAGISAESGIPTFRDAD-GLWARFDPEELATPEA------FARDPE----LVWEFY--NWRrrkalraqPNPAHLALAE 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568952430  74 LHDKELLLRLYTQNIDGLERASGipASKLVEAHGTFVTATCTVCRRSFPGEDIWVEP 130
Cdd:cd01412   74 LERRLPNVLLITQNVDGLHERAG--SRNVIELHGSLFRVRCSSCGYVGENNEEIPEE 128
SIRT4 cd01409
SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and ...
 1-122 2.16e-13

SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins have been shown to regulate gene silencing, DNA repair, metabolic enzymes, and life span.


Pssm-ID: 238700  Cd Length: 260  Bit Score: 66.55  E-value: 2.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430   1 MVGAGISTPSGIPDFRSPGsGLYSNLQQyDIPYPEaifelgfFFHNPKpffmlAKELY--------P--GHYRPNVTHYF 70
Cdd:cd01409   14 LTGAGISTESGIPDYRSEG-GLYSRTFR-PMTHQE-------FMRSPA-----ARQRYwarsfvgwPrfSAAQPNAAHRA 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568952430  71 LRLLHDKELLLRLYTQNIDGLERASGipASKLVEAHGTFVTATCTVCRRSFP 122
Cdd:cd01409   80 LAALEAAGRLHGLITQNVDGLHTKAG--SRNVVELHGSLHRVVCLSCGFRTP 129
PTZ00409 PTZ00409
Sir2 (Silent Information Regulator) protein; Provisional
 1-119 1.90e-12

Sir2 (Silent Information Regulator) protein; Provisional


Pssm-ID: 173599 [Multi-domain]  Cd Length: 271  Bit Score: 64.17  E-value: 1.90e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430   1 MVGAGISTPSGIPDFRSPGSGLYSnlqQYDipyPEAIFELGFFFHNPKPFFMLAKELYPGH-YRPNVTHYFLRLLHDKEL 79
Cdd:PTZ00409  34 LTGSGTSAESNIPSFRGPSSSIWS---KYD---PKIYGTIWGFWKYPEKIWEVIRDISSDYeIELNPGHVALSTLESLGY 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568952430  80 LLRLYTQNIDGLERASGipASKLVEAHGTFVTATCTVCRR 119
Cdd:PTZ00409 108 LKFVVTQNVDGLHEESG--NTKVIPLHGSVFEARCCTCRK 145
PRK05333 PRK05333
NAD-dependent protein deacetylase;
3-126 3.06e-11

NAD-dependent protein deacetylase;


Pssm-ID: 235415  Cd Length: 285  Bit Score: 60.85  E-value: 3.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430   3 GAGISTPSGIPDFRSpGSGLYSNLQQydIPYPEaifelgfffhnpkpfFM---LAKELY--------P--GHYRPNVTHY 69
Cdd:PRK05333  27 GAGISTDSGIPDYRD-RNGQWKRSPP--ITYQA---------------FMgsdAARRRYwarsmvgwPvfGRAQPNAAHH 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568952430  70 FLRLLHDKELLLRLYTQNIDGLERASGipASKLVEAHGTFVTATCTVCRRSFPGEDI 126
Cdd:PRK05333  89 ALARLGAAGRIERLVTQNVDGLHQRAG--SRDVIELHGRLDGVRCMGCGARHPRAEI 143
PTZ00408 PTZ00408
NAD-dependent deacetylase; Provisional
 3-121 3.20e-11

NAD-dependent deacetylase; Provisional


Pssm-ID: 240405  Cd Length: 242  Bit Score: 60.61  E-value: 3.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952430   3 GAGISTPSGIPDFRSpGSGLYSNLQQYDIPYPEAifelgfFFHNP---KPFF-MLAKELYPGHYRPNVTHYFLRLLhDKE 78
Cdd:PTZ00408  12 GAGISAESGISTFRD-GNGLWENHRVEDVATPDA------FLRNPalvQRFYnERRRALLSSSVKPNKAHFALAKL-ERE 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 568952430  79 LL---LRLYTQNIDGL-ERASgipASKLVEAHGTFVTATCTVCRRSF 121
Cdd:PTZ00408  84 YRggkVVVVTQNVDNLhERAG---STHVLHMHGELLKVRCTATGHVF 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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