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Conserved domains on  [gi|568972588|ref|XP_006532735|]
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sphingosine kinase 1 isoform X3 [Mus musculus]

Protein Classification

sphingosine kinase( domain architecture ID 1002441)

sphingosine kinase catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions; also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PLN02958 super family cl29912
diacylglycerol kinase/D-erythro-sphingosine kinase
10-343 3.55e-49

diacylglycerol kinase/D-erythro-sphingosine kinase


The actual alignment was detected with superfamily member PLN02958:

Pssm-ID: 215517 [Multi-domain]  Cd Length: 481  Bit Score: 172.74  E-value: 3.55e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588  10 LPRPCRVLVLLNPQGGKGKALQLFQSRVQPFLEEAEITFKLILTERKNHARELVCAEELGHWDALAVMSGDGLMHEVVNG 89
Cdd:PLN02958 108 LGRPKRLLVFVNPFGGKKSASKIFFDVVKPLLEDADIQLTIQETKYQLHAKEVVRTMDLSKYDGIVCVSGDGILVEVVNG 187
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588  90 LMERPDWETAIQKPLCSLPGGSGNALAASVNHYAGYEQVTNedlliNCTLLLCRRRLSPMNLLSLHTASgLRLYSVLSLS 169
Cdd:PLN02958 188 LLEREDWKTAIKLPIGMVPAGTGNGMAKSLLDSVGEPCSAT-----NAVLAIIRGHKCSLDVATILQGE-TKFFSVLMLA 261
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588 170 WGFVADVDLESEKYRRLGEIRFTVGTFFRLASLRIYQGQLAYLPV-------------GTVASKRP---ASTLVQKGPvD 233
Cdd:PLN02958 262 WGLVADIDIESEKYRWMGSARLDFYGLQRILCLRQYNGRISFVPApgfeaygeptsynGESTSKEEsgkDKQHGYQGP-D 340
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588 234 THLVPLE-----EPVPSHWT-VVPEQdfvlvlvllhthlSSELFAAPMGRCEAGVMHLFYVRaGVSRAALLRLFLAMQKG 307
Cdd:PLN02958 341 VKLENLDwrtikGPFVSVWLhNVPWG-------------GEDTLAAPDAKFSDGYLDLILIK-DCPKLALLALMTKLSDG 406
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 568972588 308 KHMEldCPYLVHVPVVAFRLEP------RSQRGVFSVDGELM 343
Cdd:PLN02958 407 THVK--SPYVMYLKVKAFVLEPgprtddPTKGGIIDSDGEVL 446
 
Name Accession Description Interval E-value
PLN02958 PLN02958
diacylglycerol kinase/D-erythro-sphingosine kinase
10-343 3.55e-49

diacylglycerol kinase/D-erythro-sphingosine kinase


Pssm-ID: 215517 [Multi-domain]  Cd Length: 481  Bit Score: 172.74  E-value: 3.55e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588  10 LPRPCRVLVLLNPQGGKGKALQLFQSRVQPFLEEAEITFKLILTERKNHARELVCAEELGHWDALAVMSGDGLMHEVVNG 89
Cdd:PLN02958 108 LGRPKRLLVFVNPFGGKKSASKIFFDVVKPLLEDADIQLTIQETKYQLHAKEVVRTMDLSKYDGIVCVSGDGILVEVVNG 187
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588  90 LMERPDWETAIQKPLCSLPGGSGNALAASVNHYAGYEQVTNedlliNCTLLLCRRRLSPMNLLSLHTASgLRLYSVLSLS 169
Cdd:PLN02958 188 LLEREDWKTAIKLPIGMVPAGTGNGMAKSLLDSVGEPCSAT-----NAVLAIIRGHKCSLDVATILQGE-TKFFSVLMLA 261
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588 170 WGFVADVDLESEKYRRLGEIRFTVGTFFRLASLRIYQGQLAYLPV-------------GTVASKRP---ASTLVQKGPvD 233
Cdd:PLN02958 262 WGLVADIDIESEKYRWMGSARLDFYGLQRILCLRQYNGRISFVPApgfeaygeptsynGESTSKEEsgkDKQHGYQGP-D 340
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588 234 THLVPLE-----EPVPSHWT-VVPEQdfvlvlvllhthlSSELFAAPMGRCEAGVMHLFYVRaGVSRAALLRLFLAMQKG 307
Cdd:PLN02958 341 VKLENLDwrtikGPFVSVWLhNVPWG-------------GEDTLAAPDAKFSDGYLDLILIK-DCPKLALLALMTKLSDG 406
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 568972588 308 KHMEldCPYLVHVPVVAFRLEP------RSQRGVFSVDGELM 343
Cdd:PLN02958 407 THVK--SPYVMYLKVKAFVLEPgprtddPTKGGIIDSDGEVL 446
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
15-120 2.05e-27

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 104.97  E-value: 2.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588   15 RVLVLLNPQGGKGKALQLFQsRVQPFLEEAEITFKLILTERKNHARELVCAEELGHWDALAVMSGDGLMHEVVNGLMERp 94
Cdd:pfam00781   1 KLLVIVNPKSGGGKGKKLLR-KVRPLLNKAGVEVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGL- 78
                          90       100
                  ....*....|....*....|....*.
gi 568972588   95 dwetAIQKPLCSLPGGSGNALAASVN 120
Cdd:pfam00781  79 ----ATRPPLGIIPLGTGNDFARALG 100
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
15-343 7.82e-20

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 88.76  E-value: 7.82e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588  15 RVLVLLNPQGGKGKALQLFQsRVQPFLEEAEITFKLILTERKNHARELVCAEELGHWDALAVMSGDGLMHEVVNGLMERP 94
Cdd:COG1597    4 RALLIVNPASGRGRAARLLE-RLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAGTG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588  95 dwetaiqKPLCSLPGGSGNALAASVNhyagyeqvTNEDLLINCTLLLcRRRLSPMNLLSLHTAsglrlYSVLSLSWGFVA 174
Cdd:COG1597   83 -------PPLGILPLGTGNDFARALG--------IPLDPEAALEALL-TGRTRRIDLGRVNGR-----YFLNVAGIGFDA 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588 175 DV--DLESEKYRRLGEIRFTVGTFFRLASLRIYQGQLAYlpVGTVASKRPASTLVQKGPVDTHLVPLeepvpshwtvvpe 252
Cdd:COG1597  142 EVveRANRALKRRLGKLAYVLAALRALLRYRPFRLRIEL--DGEEIEGEALLVAVGNGPYYGGGLRL------------- 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588 253 qdfvlvlvllhthlsselfaAPMGRCEAGVMHLFYVRAgVSRAALLRLFLAMQKGKHmeLDCPYLVHVPVVAFRLEPRsQ 332
Cdd:COG1597  207 --------------------APDASLDDGLLDVVVVRP-LSRLRLLRLLPRLLRGRH--LRHPGVRYFRAREVEIESD-R 262
                        330
                 ....*....|.
gi 568972588 333 RGVFSVDGELM 343
Cdd:COG1597  263 PLPVQLDGEPL 273
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
17-126 8.09e-13

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 64.63  E-value: 8.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588    17 LVLLNPQGGKGKALQLFQSRvQPFLEEAEItfklILTERKNHARELVCAEELGHWDALAVMSGDGLMHEVVNGLMERPDW 96
Cdd:smart00046   1 LVFVNPKSGGGKGEKLLRKF-RLLLNPRQV----FDLTKKGPAVALVIFRDVPDFNRVLVCGGDGTVGWVLNALDKRELP 75
                           90       100       110
                   ....*....|....*....|....*....|
gi 568972588    97 ETAIqkPLCSLPGGSGNALAASVNHYAGYE 126
Cdd:smart00046  76 LPEP--PVAVLPLGTGNDLARSLGWGGGYD 103
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
15-119 7.77e-06

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 47.11  E-value: 7.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588   15 RVLVLLNPQGGKGKALQLFQSrVQPFLEEAEITFKLILTERKNHARELVCAEELGHWDALAVMSGDGLMHEVVNGLMERP 94
Cdd:TIGR00147   3 EAPAILNPTAGKSNDNKPLRE-VIMLLREEGMEIHVRVTWEKGDAARYVEEARKFGVDTVIAGGGDGTINEVVNALIQLD 81
                          90       100
                  ....*....|....*....|....*
gi 568972588   95 DWETaiqkpLCSLPGGSGNALAASV 119
Cdd:TIGR00147  82 DIPA-----LGILPLGTANDFARSL 101
 
Name Accession Description Interval E-value
PLN02958 PLN02958
diacylglycerol kinase/D-erythro-sphingosine kinase
10-343 3.55e-49

diacylglycerol kinase/D-erythro-sphingosine kinase


Pssm-ID: 215517 [Multi-domain]  Cd Length: 481  Bit Score: 172.74  E-value: 3.55e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588  10 LPRPCRVLVLLNPQGGKGKALQLFQSRVQPFLEEAEITFKLILTERKNHARELVCAEELGHWDALAVMSGDGLMHEVVNG 89
Cdd:PLN02958 108 LGRPKRLLVFVNPFGGKKSASKIFFDVVKPLLEDADIQLTIQETKYQLHAKEVVRTMDLSKYDGIVCVSGDGILVEVVNG 187
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588  90 LMERPDWETAIQKPLCSLPGGSGNALAASVNHYAGYEQVTNedlliNCTLLLCRRRLSPMNLLSLHTASgLRLYSVLSLS 169
Cdd:PLN02958 188 LLEREDWKTAIKLPIGMVPAGTGNGMAKSLLDSVGEPCSAT-----NAVLAIIRGHKCSLDVATILQGE-TKFFSVLMLA 261
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588 170 WGFVADVDLESEKYRRLGEIRFTVGTFFRLASLRIYQGQLAYLPV-------------GTVASKRP---ASTLVQKGPvD 233
Cdd:PLN02958 262 WGLVADIDIESEKYRWMGSARLDFYGLQRILCLRQYNGRISFVPApgfeaygeptsynGESTSKEEsgkDKQHGYQGP-D 340
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588 234 THLVPLE-----EPVPSHWT-VVPEQdfvlvlvllhthlSSELFAAPMGRCEAGVMHLFYVRaGVSRAALLRLFLAMQKG 307
Cdd:PLN02958 341 VKLENLDwrtikGPFVSVWLhNVPWG-------------GEDTLAAPDAKFSDGYLDLILIK-DCPKLALLALMTKLSDG 406
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 568972588 308 KHMEldCPYLVHVPVVAFRLEP------RSQRGVFSVDGELM 343
Cdd:PLN02958 407 THVK--SPYVMYLKVKAFVLEPgprtddPTKGGIIDSDGEVL 446
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
15-120 2.05e-27

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 104.97  E-value: 2.05e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588   15 RVLVLLNPQGGKGKALQLFQsRVQPFLEEAEITFKLILTERKNHARELVCAEELGHWDALAVMSGDGLMHEVVNGLMERp 94
Cdd:pfam00781   1 KLLVIVNPKSGGGKGKKLLR-KVRPLLNKAGVEVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGL- 78
                          90       100
                  ....*....|....*....|....*.
gi 568972588   95 dwetAIQKPLCSLPGGSGNALAASVN 120
Cdd:pfam00781  79 ----ATRPPLGIIPLGTGNDFARALG 100
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
15-343 7.82e-20

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 88.76  E-value: 7.82e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588  15 RVLVLLNPQGGKGKALQLFQsRVQPFLEEAEITFKLILTERKNHARELVCAEELGHWDALAVMSGDGLMHEVVNGLMERP 94
Cdd:COG1597    4 RALLIVNPASGRGRAARLLE-RLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAGTG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588  95 dwetaiqKPLCSLPGGSGNALAASVNhyagyeqvTNEDLLINCTLLLcRRRLSPMNLLSLHTAsglrlYSVLSLSWGFVA 174
Cdd:COG1597   83 -------PPLGILPLGTGNDFARALG--------IPLDPEAALEALL-TGRTRRIDLGRVNGR-----YFLNVAGIGFDA 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588 175 DV--DLESEKYRRLGEIRFTVGTFFRLASLRIYQGQLAYlpVGTVASKRPASTLVQKGPVDTHLVPLeepvpshwtvvpe 252
Cdd:COG1597  142 EVveRANRALKRRLGKLAYVLAALRALLRYRPFRLRIEL--DGEEIEGEALLVAVGNGPYYGGGLRL------------- 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588 253 qdfvlvlvllhthlsselfaAPMGRCEAGVMHLFYVRAgVSRAALLRLFLAMQKGKHmeLDCPYLVHVPVVAFRLEPRsQ 332
Cdd:COG1597  207 --------------------APDASLDDGLLDVVVVRP-LSRLRLLRLLPRLLRGRH--LRHPGVRYFRAREVEIESD-R 262
                        330
                 ....*....|.
gi 568972588 333 RGVFSVDGELM 343
Cdd:COG1597  263 PLPVQLDGEPL 273
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
17-126 8.09e-13

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 64.63  E-value: 8.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588    17 LVLLNPQGGKGKALQLFQSRvQPFLEEAEItfklILTERKNHARELVCAEELGHWDALAVMSGDGLMHEVVNGLMERPDW 96
Cdd:smart00046   1 LVFVNPKSGGGKGEKLLRKF-RLLLNPRQV----FDLTKKGPAVALVIFRDVPDFNRVLVCGGDGTVGWVLNALDKRELP 75
                           90       100       110
                   ....*....|....*....|....*....|
gi 568972588    97 ETAIqkPLCSLPGGSGNALAASVNHYAGYE 126
Cdd:smart00046  76 LPEP--PVAVLPLGTGNDLARSLGWGGGYD 103
PLN02204 PLN02204
diacylglycerol kinase
12-231 9.13e-11

diacylglycerol kinase


Pssm-ID: 215126 [Multi-domain]  Cd Length: 601  Bit Score: 63.37  E-value: 9.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588  12 RPCRVLVLLNPQGGKGKALQLFQSrVQPFLEEAEITFKLILTERKNHARELVCA---EELGHWDALAVMSGDGLMHEVVN 88
Cdd:PLN02204 158 RPKNLLVFVHPLSGKGSGSRTWET-VSPIFIRAKVKTKVIVTERAGHAFDVMASisnKELKSYDGVIAVGGDGFFNEILN 236
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588  89 GLM------ERP----DWETAIQKPLCSL--PGGSGNALAASVNHY-----AGYEQ-------------------VTNE- 131
Cdd:PLN02204 237 GYLlsrlkvPYPpspsDSVHSVQSRGSSSvhEPNETVHECDNEDHSpllsdSVQEVmnfrtengscegdqdsdfpFPNEr 316
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588 132 -----------DLLINCT------------LLLCRR-RLSPMNLLSLHTASGLRL-----YSVLSLSWGFVADVDLESEK 182
Cdd:PLN02204 317 frfgiipagstDAIVMCTtgerdpvtsalhIILGRRvCLDIAQVVRWKTTSTSEIepyvrYAASFAGYGFYGDVISESEK 396
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568972588 183 YRRLGEIRFT-VGT--FFRLASlriYQGQLAYLPVGTVASKRPASTLVQKGP 231
Cdd:PLN02204 397 YRWMGPKRYDyAGTkvFLKHRS---YEAEVAYLETESEKSKASSEARKRTGP 445
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
15-119 7.77e-06

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 47.11  E-value: 7.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588   15 RVLVLLNPQGGKGKALQLFQSrVQPFLEEAEITFKLILTERKNHARELVCAEELGHWDALAVMSGDGLMHEVVNGLMERP 94
Cdd:TIGR00147   3 EAPAILNPTAGKSNDNKPLRE-VIMLLREEGMEIHVRVTWEKGDAARYVEEARKFGVDTVIAGGGDGTINEVVNALIQLD 81
                          90       100
                  ....*....|....*....|....*
gi 568972588   95 DWETaiqkpLCSLPGGSGNALAASV 119
Cdd:TIGR00147  82 DIPA-----LGILPLGTANDFARSL 101
PRK11914 PRK11914
diacylglycerol kinase; Reviewed
15-113 7.04e-03

diacylglycerol kinase; Reviewed


Pssm-ID: 237021 [Multi-domain]  Cd Length: 306  Bit Score: 37.84  E-value: 7.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972588  15 RVLVLLNPQGGKGKALQLFQSRVQPfLEEAEITFKLILTERKNHARELVCAEELGHWDALAVMSGDGLmheVVNGLMERP 94
Cdd:PRK11914  10 KVTVLTNPLSGHGAAPHAAERAIAR-LHHRGVDVVEIVGTDAHDARHLVAAALAKGTDALVVVGGDGV---ISNALQVLA 85
                         90
                 ....*....|....*....
gi 568972588  95 DWETaiqkPLCSLPGGSGN 113
Cdd:PRK11914  86 GTDI----PLGIIPAGTGN 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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