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Conserved domains on  [gi|569005623|ref|XP_006531731|]
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latent-transforming growth factor beta-binding protein 3 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 411-452 6.53e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.44  E-value: 6.53e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 569005623   411 QCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPADGTAAFKEIC 452
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 926-968 5.27e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.35  E-value: 5.27e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 569005623   926 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 968
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
352-387 2.09e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.09e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 569005623    352 DINECAMPGMCRHG-DCLNNPGSYRCVCPPGHSLGPS 387
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
741-781 3.35e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 3.35e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 569005623    741 DVNECSEGTPCSPG-WCENLPGSYRCTCAQGYEpaqDGLSCI 781
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1079-1114 5.27e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 5.27e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 569005623   1079 DVDECQDPAACRPG-RCVNLPGSYRCECHPPWEPGPS 1114
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 657-691 8.99e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 8.99e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 569005623  657 DLNECTKPHLCGDGGFCINFPGHYKCNCYPGYRLK 691
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
782-822 1.54e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.54e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 569005623    782 DVDECEAGKVCQDG-ICTNTPGSFQCQCLSGYHlsrDRSRCE 822
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1143-1179 2.65e-05

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 42.65  E-value: 2.65e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 569005623  1143 GMCMGPLAGpALTFDDCCCR-QGRGWGTQCRPCPPRGT 1179
Cdd:pfam00683    1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPGT 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
863-896 3.90e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 3.90e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 569005623    863 DIDECSqDPGLCLPHGACENLQGSYVCVCDEGFT 896
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
823-862 8.00e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 8.00e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 569005623    823 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 862
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1033-1061 5.44e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 5.44e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 569005623   1033 DVDECLDESNCRNG-VCENTRGGYRCACTP 1061
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
700-733 1.64e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.64e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 569005623    700 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYRS 733
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
613-656 2.27e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.27e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 569005623    613 DVNECEAE-PCGPGkGICMNTGGSYNCHCNRGYRlhvgaGGRSCV 656
Cdd:smart00179    1 DIDECASGnPCQNG-GTCVNTVGSYRCECPPGYT-----DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1251-1289 4.65e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 4.65e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 569005623   1251 DIDECRELNqrglLCKS-ERCVNTSGSFRCVCKAGFTRSR 1289
Cdd:smart00179    1 DIDECASGN----PCQNgGTCVNTVGSYRCECPPGYTDGR 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 288-318 4.97e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.10  E-value: 4.97e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569005623   288 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 318
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 411-452 6.53e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.44  E-value: 6.53e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 569005623   411 QCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPADGTAAFKEIC 452
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 926-968 5.27e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.35  E-value: 5.27e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 569005623   926 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 968
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
352-387 2.09e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.09e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 569005623    352 DINECAMPGMCRHG-DCLNNPGSYRCVCPPGHSLGPS 387
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
741-781 3.35e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 3.35e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 569005623    741 DVNECSEGTPCSPG-WCENLPGSYRCTCAQGYEpaqDGLSCI 781
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1079-1114 5.27e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 5.27e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 569005623   1079 DVDECQDPAACRPG-RCVNLPGSYRCECHPPWEPGPS 1114
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 657-691 8.99e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 8.99e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 569005623  657 DLNECTKPHLCGDGGFCINFPGHYKCNCYPGYRLK 691
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
782-822 1.54e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.54e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 569005623    782 DVDECEAGKVCQDG-ICTNTPGSFQCQCLSGYHlsrDRSRCE 822
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
657-689 1.78e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.78e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 569005623    657 DLNECTKPHLCGDGGFCINFPGHYKCNCYPGYR 689
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 352-384 2.54e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.54e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 569005623  352 DINECAMPGMCR-HGDCLNNPGSYRCVCPPGHSL 384
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTG 34
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1143-1179 2.65e-05

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 42.65  E-value: 2.65e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 569005623  1143 GMCMGPLAGpALTFDDCCCR-QGRGWGTQCRPCPPRGT 1179
Cdd:pfam00683    1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPGT 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 741-772 3.70e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.70e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 569005623  741 DVNECSEGTPCSP-GWCENLPGSYRCTCAQGYE 772
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
863-896 3.90e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 3.90e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 569005623    863 DIDECSqDPGLCLPHGACENLQGSYVCVCDEGFT 896
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 863-898 5.26e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 5.26e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 569005623  863 DIDECSQdPGLCLPHGACENLQGSYVCVCDEGFTLT 898
Cdd:cd00054     1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 782-816 6.60e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 6.60e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 569005623  782 DVDECEAGKVCQ-DGICTNTPGSFQCQCLSGYHLSR 816
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1079-1119 6.93e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 6.93e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 569005623 1079 DVDECQDPAACRP-GRCVNLPGSYRCECHPPWEpgpsGRDCQ 1119
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
823-862 8.00e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 8.00e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 569005623    823 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 862
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 823-862 1.87e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.87e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 569005623  823 DIDECDFPAAC-IGGDCINTNGSYRCLCPQGHRlvgGRKCQ 862
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT---GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1033-1061 5.44e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 5.44e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 569005623   1033 DVDECLDESNCRNG-VCENTRGGYRCACTP 1061
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
823-852 7.44e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 7.44e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569005623   823 DIDECDFPAA-C-IGGDCINTNGSYRCLCPQG 852
Cdd:pfam07645    1 DVDECATGTHnCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
352-381 1.17e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.17e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569005623   352 DINECAMPG-MC-RHGDCLNNPGSYRCVCPPG 381
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
700-733 1.64e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.64e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 569005623    700 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYRS 733
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1033-1061 1.66e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.66e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 569005623 1033 DVDECLDESNCRN-GVCENTRGGYRCACTP 1061
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
613-656 2.27e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.27e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 569005623    613 DVNECEAE-PCGPGkGICMNTGGSYNCHCNRGYRlhvgaGGRSCV 656
Cdd:smart00179    1 DIDECASGnPCQNG-GTCVNTVGSYRCECPPGYT-----DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
782-811 2.83e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 2.83e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569005623   782 DVDEC-EAGKVCQD-GICTNTPGSFQCQCLSG 811
Cdd:pfam07645    1 DVDECaTGTHNCPAnTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 700-732 3.37e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.37e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 569005623  700 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYR 732
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 613-647 3.72e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.72e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 569005623  613 DVNECE-AEPCGPGkGICMNTGGSYNCHCNRGYRLH 647
Cdd:cd00054     1 DIDECAsGNPCQNG-GTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
1251-1289 4.65e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 4.65e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 569005623   1251 DIDECRELNqrglLCKS-ERCVNTSGSFRCVCKAGFTRSR 1289
Cdd:smart00179    1 DIDECASGN----PCQNgGTCVNTVGSYRCECPPGYTDGR 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 288-318 4.97e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.10  E-value: 4.97e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569005623   288 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 318
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34
 
Name Accession Description Interval E-value
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 411-452 6.53e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 58.44  E-value: 6.53e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 569005623   411 QCQHPLTTRLTRQLCCC-SVGKAWGARCQRCPADGTAAFKEIC 452
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 926-968 5.27e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 50.35  E-value: 5.27e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 569005623   926 CDSVLATNVTQQECCC-SLGAGWGDHCEiyPCPVYSSAEFHSLC 968
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCE--LCPPPGTDEFRELC 44
EGF_CA smart00179
Calcium-binding EGF-like domain;
352-387 2.09e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 2.09e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 569005623    352 DINECAMPGMCRHG-DCLNNPGSYRCVCPPGHSLGPS 387
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
741-781 3.35e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.93  E-value: 3.35e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 569005623    741 DVNECSEGTPCSPG-WCENLPGSYRCTCAQGYEpaqDGLSCI 781
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1079-1114 5.27e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 5.27e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 569005623   1079 DVDECQDPAACRPG-RCVNLPGSYRCECHPPWEPGPS 1114
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 657-691 8.99e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.78  E-value: 8.99e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 569005623  657 DLNECTKPHLCGDGGFCINFPGHYKCNCYPGYRLK 691
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
782-822 1.54e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.54e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 569005623    782 DVDECEAGKVCQDG-ICTNTPGSFQCQCLSGYHlsrDRSRCE 822
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
657-689 1.78e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 1.78e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 569005623    657 DLNECTKPHLCGDGGFCINFPGHYKCNCYPGYR 689
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 352-384 2.54e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 2.54e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 569005623  352 DINECAMPGMCR-HGDCLNNPGSYRCVCPPGHSL 384
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTG 34
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1143-1179 2.65e-05

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 42.65  E-value: 2.65e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 569005623  1143 GMCMGPLAGpALTFDDCCCR-QGRGWGTQCRPCPPRGT 1179
Cdd:pfam00683    1 GRCSNPLPG-NVTKSECCCTsVGRAWGSPCELCPPPGT 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 741-772 3.70e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 3.70e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 569005623  741 DVNECSEGTPCSP-GWCENLPGSYRCTCAQGYE 772
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
863-896 3.90e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 3.90e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 569005623    863 DIDECSqDPGLCLPHGACENLQGSYVCVCDEGFT 896
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 863-898 5.26e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.47  E-value: 5.26e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 569005623  863 DIDECSQdPGLCLPHGACENLQGSYVCVCDEGFTLT 898
Cdd:cd00054     1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 782-816 6.60e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 6.60e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 569005623  782 DVDECEAGKVCQ-DGICTNTPGSFQCQCLSGYHLSR 816
Cdd:cd00054     1 DIDECASGNPCQnGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1079-1119 6.93e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.08  E-value: 6.93e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 569005623 1079 DVDECQDPAACRP-GRCVNLPGSYRCECHPPWEpgpsGRDCQ 1119
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT----GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
823-862 8.00e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 8.00e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 569005623    823 DIDECDFPAACI-GGDCINTNGSYRCLCPQGHRlvGGRKCQ 862
Cdd:smart00179    1 DIDECASGNPCQnGGTCVNTVGSYRCECPPGYT--DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 823-862 1.87e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.87e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 569005623  823 DIDECDFPAAC-IGGDCINTNGSYRCLCPQGHRlvgGRKCQ 862
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCSCPPGYT---GRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1033-1061 5.44e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 5.44e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 569005623   1033 DVDECLDESNCRNG-VCENTRGGYRCACTP 1061
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPP 30
EGF_CA pfam07645
Calcium-binding EGF domain;
823-852 7.44e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 7.44e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569005623   823 DIDECDFPAA-C-IGGDCINTNGSYRCLCPQG 852
Cdd:pfam07645    1 DVDECATGTHnCpANTVCVNTIGSFECRCPDG 32
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 858-901 1.16e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 41.99  E-value: 1.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 569005623  858 GRKCQDIDECSqdpglCLPHG---ACENLQGSYVCVCDEGFTLTQDQ 901
Cdd:cd01475   181 GKICVVPDLCA-----TLSHVcqqVCISTPGSYLCACTEGYALLEDN 222
EGF_CA pfam07645
Calcium-binding EGF domain;
352-381 1.17e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.17e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569005623   352 DINECAMPG-MC-RHGDCLNNPGSYRCVCPPG 381
Cdd:pfam07645    1 DVDECATGThNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
700-733 1.64e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.64e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 569005623    700 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYRS 733
Cdd:smart00179    1 DIDECASGNPCqNGGTCVNTVGSYRCE-CPPGYTD 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1033-1061 1.66e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.66e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 569005623 1033 DVDECLDESNCRN-GVCENTRGGYRCACTP 1061
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPP 30
EGF_CA smart00179
Calcium-binding EGF-like domain;
613-656 2.27e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 2.27e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 569005623    613 DVNECEAE-PCGPGkGICMNTGGSYNCHCNRGYRlhvgaGGRSCV 656
Cdd:smart00179    1 DIDECASGnPCQNG-GTCVNTVGSYRCECPPGYT-----DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
782-811 2.83e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 2.83e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569005623   782 DVDEC-EAGKVCQD-GICTNTPGSFQCQCLSG 811
Cdd:pfam07645    1 DVDECaTGTHNCPAnTVCVNTIGSFECRCPDG 32
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 780-817 3.06e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 40.83  E-value: 3.06e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 569005623  780 CIDVDECEAG-KVCQDgICTNTPGSFQCQCLSGYHLSRD 817
Cdd:cd01475   184 CVVPDLCATLsHVCQQ-VCISTPGSYLCACTEGYALLED 221
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 700-732 3.37e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.37e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 569005623  700 DIDECRDPSTC-PDGKCENKPGSFKCIaCQPGYR 732
Cdd:cd00054     1 DIDECASGNPCqNGGTCVNTVGSYRCS-CPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 613-647 3.72e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 3.72e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 569005623  613 DVNECE-AEPCGPGkGICMNTGGSYNCHCNRGYRLH 647
Cdd:cd00054     1 DIDECAsGNPCQNG-GTCVNTVGSYRCSCPPGYTGR 35
EGF smart00181
Epidermal growth factor-like domain;
355-387 4.30e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 35.96  E-value: 4.30e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 569005623    355 ECAMPGMCRHGDCLNNPGSYRCVCPPGHSLGPS 387
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYTGDKR 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1251-1289 4.65e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 4.65e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 569005623   1251 DIDECRELNqrglLCKS-ERCVNTSGSFRCVCKAGFTRSR 1289
Cdd:smart00179    1 DIDECASGN----PCQNgGTCVNTVGSYRCECPPGYTDGR 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 288-318 4.97e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.10  E-value: 4.97e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569005623   288 SNPLPG-LTKQEDCCGSIGTAWGqSKCHKCPQ 318
Cdd:pfam00683    4 SNPLPGnVTKSECCCTSVGRAWG-SPCELCPP 34
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 660-693 9.75e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.15  E-value: 9.75e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 569005623  660 ECTKPHLCGDGGFCINFPGHYKCNCYPGYRLKAS 693
Cdd:cd00053     1 ECAASNPCSNGGTCVNTPGSYRCVCPPGYTGDRS 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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