|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-94 |
6.17e-48 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
:
Pssm-ID: 436519 Cd Length: 95 Bit Score: 165.97 E-value: 6.17e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1 MDAESIRLNNENLWAWLVRLLSKNPEWLSAKLRSFLPTMDLDCSYEPSNP-EVIHRQLNRLFAQGMATWKSFINDLCFEL 79
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPtQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 568957139 80 DVPLDMEIPLVSIWG 94
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1566-1875 |
2.73e-34 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 138.00 E-value: 2.73e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1566 LAAILPKLPELRKFDLSHNQIGDVGTQCL-AAILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGD 1644
Cdd:COG5238 143 LIQVLKDPLGGNAVHLLGLAARLGLLAAIsMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGD 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1645 VGTQCLAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTALELAQRL--PPQLRVLCLPSS 1722
Cdd:COG5238 223 EGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALqgNTTLTSLDLSVN 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1723 HLGPEGALGLAQALEQCPHIEEVSLAENNlaggvprfskrlpllrqidlefckIEDQAARHLAANLTLFPALEKLLLSGN 1802
Cdd:COG5238 303 RIGDEGAIALAEGLQGNKTLHTLNLAYNG------------------------IGAQGAIALAKALQENTTLHSLDLSDN 358
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568957139 1803 LLGDEVAAELAQVLPQMGQLKKVNLEWNRITARGAQLLAQGLvQGSCVPVIRLWNNPILNDVAQSLQSQEPRL 1875
Cdd:COG5238 359 QIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
223-385 |
9.25e-31 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
:
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 119.72 E-value: 9.25e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 223 RVTVLLGKAGMGKTTLAYRLRWRWAQGQLDR-FQALFLFEFRQLNMITQLPTLPQLLFDLYLMPESEPDAVFQYLKENAQ 301
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQgFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 302 EVLLIFDGLDEALHADSVgTDNAGSALTLFSELCHGNLLPGCWVMTTSRPG---KLPSCVPtEAATVHMWGFDGLRVEKY 378
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQ-LDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGLE-EPRYLEVRGFSESDRKQY 158
|
....*..
gi 568957139 379 VTCFFSD 385
Cdd:pfam05729 159 VRKYFSD 165
|
|
| RNA1 super family |
cl34950 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1415-1686 |
3.17e-26 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
The actual alignment was detected with superfamily member COG5238:
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 114.12 E-value: 3.17e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1415 LETEHSHLMIQLVETYARLQQLSLSQVSFNDN--DGTSSKLLQNILLSSCELKSFRLTFSQVSTKSLTHLAFGLGHCHHL 1492
Cdd:COG5238 159 LGLAARLGLLAAISMAKALQNNSVETVYLGCNqiGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSL 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1493 EELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGASSLALLIQGLSRMTLLQDLCLSHNQIGDVGTQCLAAILPK 1572
Cdd:COG5238 239 TTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1573 LPELRKFDLSHNQIGDVGTQCLAAILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGDVGTQCLAA 1652
Cdd:COG5238 319 NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALID 398
|
250 260 270
....*....|....*....|....*....|....
gi 568957139 1653 ILpKLPELRKFDLSGNRIGPAGGVQLVKSLTHFE 1686
Cdd:COG5238 399 AL-QTNRLHTLILDGNLIGAEAQQRLEQLLERIK 431
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
223-955 |
6.27e-23 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
:
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 106.81 E-value: 6.27e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 223 RVTVLLGKAGMGKTTLAYRLRWRWAQGQLDRFQAL-FLFEFRQLNmitQLPTLPQLLFDLYLMPESEPDAVFQYLKENAQ 301
Cdd:COG5635 181 KRLLILGEPGSGKTTLLRYLALELAERYLDAEDPIpILIELRDLA---EEASLEDLLAEALEKRGGEPEDALERLLRNGR 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 302 eVLLIFDGLDEAlhADSVGTDNAGSALTLFSELChgnllPGCWVMTTSRPGKLPSCVPTEAATVHMWGFDGLRVEKYVTC 381
Cdd:COG5635 258 -LLLLLDGLDEV--PDEADRDEVLNQLRRFLERY-----PKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKK 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 382 FFSDLLSQ-ELALKEMRTNARLRGMCAIPALCTVTCFCLRrllpgsspgQSAALLPTITQLYLQMVETF---------SP 451
Cdd:COG5635 330 WFEATERKaERLLEALEENPELRELARNPLLLTLLALLLR---------ERGELPDTRAELYEQFVELLlerwdeqrgLT 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 452 SETLLDTSILG--FGKVALRGLDTGKVVFSVED----ISPQLMSFGAVHSLLTSFCIHT----RPGHEEigYAFVHLSLQ 521
Cdd:COG5635 401 IYRELSREELRelLSELALAMQENGRTEFAREEleeiLREYLGRRKDAEALLDELLLRTgllvERGEGR--YSFAHRSFQ 478
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 522 EFFAALYLMASHTVD-KDTLVEYVTlNSHW---VLRTKGRLGLSDHLPAFLAGLASHTCHMFLCQLAQQDRAWVGSRQAA 597
Cdd:COG5635 479 EYLAARALVEELDEElLELLAEHLE-DPRWrevLLLLAGLLDDVKQIKELIDALLARDDAAALALAAALLLALLLALALL 557
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 598 VIQVLRKLASRKLTGPKMIELYHCVAETQDLELARFTAQSLPSRLSFHNFPLTHADLAALANILEHRDDPIHLDFDGCPL 677
Cdd:COG5635 558 ALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALLLALLLLLLLLLLAELL 637
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 678 EPHCPEALVGCGQVENLSFKSRKCGDAFAEALCRSLPTMGSLKTLGLTGSRITAQGISHLIQTLPLCSQLEEVSLHD-NQ 756
Cdd:COG5635 638 LLALLALVLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAELLLALLALASLLLLLLLALALALALLLLAVLLAAaLD 717
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 757 LKDPEVLSLVELLPSLPKLQKLEELDLIFYLSPVTETATQQSGASDVQGKDSLKEGQSRSLQLRLQKCQLRIRDAEALVE 836
Cdd:COG5635 718 LLLLLVLLLALLLVLALALSLLLLALALLLAGALLLESSALLAVLLASLLLALLLLSLLLLLVLLLALALLASLLLALLL 797
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 837 LFQKSPQLEEVNLSGNHLEDDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTYVLKAMSTCGTLEDLHISLLNNTVVLTF 916
Cdd:COG5635 798 LILLLVLLGSLLLLRLLDDLALLLLLALAAARLLLSSLALVALELARASLGASLVLLALLLATLLLLLLLLLALALALLS 877
|
730 740 750
....*....|....*....|....*....|....*....
gi 568957139 917 AQEPREQEGSCKGRAPLISFVSPVTSELSQRSRRIRLTH 955
Cdd:COG5635 878 LLSLSSLALLSLLGLLLALSLLALLLLSLSLALAALLLA 916
|
|
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
817-1126 |
7.52e-10 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 62.37 E-value: 7.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 817 LQLRLQKCQLRIRDAEalvELFQKSPQLEEVNLSGNHLEDDGCRLVAEAASQLHIAQKLDLSDN--GLSQTGVTYVLKAM 894
Cdd:cd00116 1 LQLSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNetGRIPRGLQSLLQGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 895 STCGTLEdlHISLLNNTvvLTFAqepreqegsckGRAPLISFVSPVTSELSQrsrrirLTHCGFLAKHTETLCEALRaSC 974
Cdd:cd00116 78 TKGCGLQ--ELDLSDNA--LGPD-----------GCGVLESLLRSSSLQELK------LNNNGLGDRGLRLLAKGLK-DL 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 975 QtHNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMDAVFSLVQCLSSLQWVFHLDvsLESDCIFLRGAGT 1054
Cdd:cd00116 136 P-PALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLD--LNNNGLTDEGASA 212
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568957139 1055 SRDALEPKFQtgVQVLELSQrytsrsfCLqeCQLEPTSlTFLCATLEKSPGPLEVQLSCKSLSDDSLKILLQ 1126
Cdd:cd00116 213 LAETLASLKS--LEVLNLGD-------NN--LTDAGAA-ALASALLSPNISLLTLSLSCNDITDDGAKDLAE 272
|
|
| PPP1R42 super family |
cl42388 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
977-1277 |
2.82e-06 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
The actual alignment was detected with superfamily member cd00116:
Pssm-ID: 455733 [Multi-domain] Cd Length: 319 Bit Score: 51.59 E-value: 2.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 977 HNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMD--AVFSLVQCLSSLQWVFHLDVSlesDCIFLrgagt 1054
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLQELDLS---DNALG----- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1055 srdalepkfQTGVQVLE-LSQRYTSRSFCLQECQLEPTSLTFLCAtlekspGPLEVQLSCKSLsddslkILLQCLpqlpq 1133
Cdd:cd00116 95 ---------PDGCGVLEsLLRSSSLQELKLNNNGLGDRGLRLLAK------GLKDLPPALEKL------VLGRNR----- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1134 lsllqlrhtvLSSRSPFLLADIFNLCPRVRKVTL----------RSLCHAVLHFdsneeQEGVCCGFPGCSLSQEHMETL 1203
Cdd:cd00116 149 ----------LEGASCEALAKALRANRDLKELNLanngigdagiRALAEGLKAN-----CNLEVLDLNNNGLTDEGASAL 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568957139 1204 CCALSKCNALSQLDLTDNLLGDIGLRCLLECLPQLPIS-GWLDLSHNNISQEGILYLLETLPSYPNIQEVSVSLS 1277
Cdd:cd00116 214 AETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISlLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-94 |
6.17e-48 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
Pssm-ID: 436519 Cd Length: 95 Bit Score: 165.97 E-value: 6.17e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1 MDAESIRLNNENLWAWLVRLLSKNPEWLSAKLRSFLPTMDLDCSYEPSNP-EVIHRQLNRLFAQGMATWKSFINDLCFEL 79
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPtQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 568957139 80 DVPLDMEIPLVSIWG 94
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1566-1875 |
2.73e-34 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 138.00 E-value: 2.73e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1566 LAAILPKLPELRKFDLSHNQIGDVGTQCL-AAILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGD 1644
Cdd:COG5238 143 LIQVLKDPLGGNAVHLLGLAARLGLLAAIsMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGD 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1645 VGTQCLAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTALELAQRL--PPQLRVLCLPSS 1722
Cdd:COG5238 223 EGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALqgNTTLTSLDLSVN 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1723 HLGPEGALGLAQALEQCPHIEEVSLAENNlaggvprfskrlpllrqidlefckIEDQAARHLAANLTLFPALEKLLLSGN 1802
Cdd:COG5238 303 RIGDEGAIALAEGLQGNKTLHTLNLAYNG------------------------IGAQGAIALAKALQENTTLHSLDLSDN 358
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568957139 1803 LLGDEVAAELAQVLPQMGQLKKVNLEWNRITARGAQLLAQGLvQGSCVPVIRLWNNPILNDVAQSLQSQEPRL 1875
Cdd:COG5238 359 QIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1490-1752 |
4.81e-31 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 125.55 E-value: 4.81e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1490 HHLEELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGAS--SLALLIQGLSRMTLLQDLCLSHNQIGDVGTQCLA 1567
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLE 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1568 AILpKLPELRKFDLSHNQIGDVGTQCLAAILPKLPE-LRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGDVG 1646
Cdd:cd00116 103 SLL-RSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1647 TQCLAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTALELAQRLP---PQLRVLCLPSSH 1723
Cdd:cd00116 182 IRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLspnISLLTLSLSCND 261
|
250 260
....*....|....*....|....*....
gi 568957139 1724 LGPEGALGLAQALEQCPHIEEVSLAENNL 1752
Cdd:cd00116 262 ITDDGAKDLAEVLAEKESLLELDLRGNKF 290
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
223-385 |
9.25e-31 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 119.72 E-value: 9.25e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 223 RVTVLLGKAGMGKTTLAYRLRWRWAQGQLDR-FQALFLFEFRQLNMITQLPTLPQLLFDLYLMPESEPDAVFQYLKENAQ 301
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQgFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 302 EVLLIFDGLDEALHADSVgTDNAGSALTLFSELCHGNLLPGCWVMTTSRPG---KLPSCVPtEAATVHMWGFDGLRVEKY 378
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQ-LDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGLE-EPRYLEVRGFSESDRKQY 158
|
....*..
gi 568957139 379 VTCFFSD 385
Cdd:pfam05729 159 VRKYFSD 165
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1415-1686 |
3.17e-26 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 114.12 E-value: 3.17e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1415 LETEHSHLMIQLVETYARLQQLSLSQVSFNDN--DGTSSKLLQNILLSSCELKSFRLTFSQVSTKSLTHLAFGLGHCHHL 1492
Cdd:COG5238 159 LGLAARLGLLAAISMAKALQNNSVETVYLGCNqiGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSL 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1493 EELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGASSLALLIQGLSRMTLLQDLCLSHNQIGDVGTQCLAAILPK 1572
Cdd:COG5238 239 TTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1573 LPELRKFDLSHNQIGDVGTQCLAAILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGDVGTQCLAA 1652
Cdd:COG5238 319 NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALID 398
|
250 260 270
....*....|....*....|....*....|....
gi 568957139 1653 ILpKLPELRKFDLSGNRIGPAGGVQLVKSLTHFE 1686
Cdd:COG5238 399 AL-QTNRLHTLILDGNLIGAEAQQRLEQLLERIK 431
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1407-1654 |
1.89e-25 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 109.37 E-value: 1.89e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1407 ALRLAHCDLETEHS----HLMIQLVETYARLQQLSLSQVSFNDndgTSSKLLQNILLSScELKSFRLTFSQVSTKSLTHL 1482
Cdd:cd00116 53 LKELCLSLNETGRIprglQSLLQGLTKGCGLQELDLSDNALGP---DGCGVLESLLRSS-SLQELKLNNNGLGDRGLRLL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1483 AFGLGHC-HHLEELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGASSLALLIQGLSRMTLLQDLCLSHNQIGDV 1561
Cdd:cd00116 129 AKGLKDLpPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1562 GTQCLAAILPKLPELRKFDLSHNQIGDVGTQCLAAILPKL-PELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRN 1640
Cdd:cd00116 209 GASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPnISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
250
....*....|....
gi 568957139 1641 QIGDVGTQCLAAIL 1654
Cdd:cd00116 289 KFGEEGAQLLAESL 302
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
223-955 |
6.27e-23 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 106.81 E-value: 6.27e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 223 RVTVLLGKAGMGKTTLAYRLRWRWAQGQLDRFQAL-FLFEFRQLNmitQLPTLPQLLFDLYLMPESEPDAVFQYLKENAQ 301
Cdd:COG5635 181 KRLLILGEPGSGKTTLLRYLALELAERYLDAEDPIpILIELRDLA---EEASLEDLLAEALEKRGGEPEDALERLLRNGR 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 302 eVLLIFDGLDEAlhADSVGTDNAGSALTLFSELChgnllPGCWVMTTSRPGKLPSCVPTEAATVHMWGFDGLRVEKYVTC 381
Cdd:COG5635 258 -LLLLLDGLDEV--PDEADRDEVLNQLRRFLERY-----PKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKK 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 382 FFSDLLSQ-ELALKEMRTNARLRGMCAIPALCTVTCFCLRrllpgsspgQSAALLPTITQLYLQMVETF---------SP 451
Cdd:COG5635 330 WFEATERKaERLLEALEENPELRELARNPLLLTLLALLLR---------ERGELPDTRAELYEQFVELLlerwdeqrgLT 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 452 SETLLDTSILG--FGKVALRGLDTGKVVFSVED----ISPQLMSFGAVHSLLTSFCIHT----RPGHEEigYAFVHLSLQ 521
Cdd:COG5635 401 IYRELSREELRelLSELALAMQENGRTEFAREEleeiLREYLGRRKDAEALLDELLLRTgllvERGEGR--YSFAHRSFQ 478
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 522 EFFAALYLMASHTVD-KDTLVEYVTlNSHW---VLRTKGRLGLSDHLPAFLAGLASHTCHMFLCQLAQQDRAWVGSRQAA 597
Cdd:COG5635 479 EYLAARALVEELDEElLELLAEHLE-DPRWrevLLLLAGLLDDVKQIKELIDALLARDDAAALALAAALLLALLLALALL 557
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 598 VIQVLRKLASRKLTGPKMIELYHCVAETQDLELARFTAQSLPSRLSFHNFPLTHADLAALANILEHRDDPIHLDFDGCPL 677
Cdd:COG5635 558 ALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALLLALLLLLLLLLLAELL 637
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 678 EPHCPEALVGCGQVENLSFKSRKCGDAFAEALCRSLPTMGSLKTLGLTGSRITAQGISHLIQTLPLCSQLEEVSLHD-NQ 756
Cdd:COG5635 638 LLALLALVLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAELLLALLALASLLLLLLLALALALALLLLAVLLAAaLD 717
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 757 LKDPEVLSLVELLPSLPKLQKLEELDLIFYLSPVTETATQQSGASDVQGKDSLKEGQSRSLQLRLQKCQLRIRDAEALVE 836
Cdd:COG5635 718 LLLLLVLLLALLLVLALALSLLLLALALLLAGALLLESSALLAVLLASLLLALLLLSLLLLLVLLLALALLASLLLALLL 797
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 837 LFQKSPQLEEVNLSGNHLEDDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTYVLKAMSTCGTLEDLHISLLNNTVVLTF 916
Cdd:COG5635 798 LILLLVLLGSLLLLRLLDDLALLLLLALAAARLLLSSLALVALELARASLGASLVLLALLLATLLLLLLLLLALALALLS 877
|
730 740 750
....*....|....*....|....*....|....*....
gi 568957139 917 AQEPREQEGSCKGRAPLISFVSPVTSELSQRSRRIRLTH 955
Cdd:COG5635 878 LLSLSSLALLSLLGLLLALSLLALLLLSLSLALAALLLA 916
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
611-865 |
1.02e-12 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 71.23 E-value: 1.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 611 TGPKMIELYHCVAETQDLELARFtaQSLPSRLSFHNFPLTHADLaalanilehrdDPIHLDFDGCPLePHCPEAL--VGC 688
Cdd:cd00116 79 KGCGLQELDLSDNALGPDGCGVL--ESLLRSSSLQELKLNNNGL-----------GDRGLRLLAKGL-KDLPPALekLVL 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 689 GQvenlsfksRKCGDAFAEALCRSLPTMGSLKTLGLTGSRITAQGISHLIQTLPLCSQLEEVSLHDNQLKDPEVLSLVEL 768
Cdd:cd00116 145 GR--------NRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAET 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 769 LPSLPKLQKLEELDlifylSPVTETatqqsGASDVqgKDSLKEGQSRSLQLRLQKCQLRIRDAEALVELFQKSPQLEEVN 848
Cdd:cd00116 217 LASLKSLEVLNLGD-----NNLTDA-----GAAAL--ASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELD 284
|
250
....*....|....*..
gi 568957139 849 LSGNHLEDDGCRLVAEA 865
Cdd:cd00116 285 LRGNKFGEEGAQLLAES 301
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
817-1126 |
7.52e-10 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 62.37 E-value: 7.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 817 LQLRLQKCQLRIRDAEalvELFQKSPQLEEVNLSGNHLEDDGCRLVAEAASQLHIAQKLDLSDN--GLSQTGVTYVLKAM 894
Cdd:cd00116 1 LQLSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNetGRIPRGLQSLLQGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 895 STCGTLEdlHISLLNNTvvLTFAqepreqegsckGRAPLISFVSPVTSELSQrsrrirLTHCGFLAKHTETLCEALRaSC 974
Cdd:cd00116 78 TKGCGLQ--ELDLSDNA--LGPD-----------GCGVLESLLRSSSLQELK------LNNNGLGDRGLRLLAKGLK-DL 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 975 QtHNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMDAVFSLVQCLSSLQWVFHLDvsLESDCIFLRGAGT 1054
Cdd:cd00116 136 P-PALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLD--LNNNGLTDEGASA 212
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568957139 1055 SRDALEPKFQtgVQVLELSQrytsrsfCLqeCQLEPTSlTFLCATLEKSPGPLEVQLSCKSLSDDSLKILLQ 1126
Cdd:cd00116 213 LAETLASLKS--LEVLNLGD-------NN--LTDAGAA-ALASALLSPNISLLTLSLSCNDITDDGAKDLAE 272
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
517-632 |
2.20e-09 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 56.92 E-value: 2.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 517 HLSLQEFFAALYLMASHTVDKDTLV----------EYVTLNSHWVLRTKGRLglsDHLPAFLAGLASHTCHMFL-----C 581
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPLkeffglrkreSLKSLLDKALKSKNGHL---DLFLRFLFGLLNEENQRLLegllgC 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 568957139 582 QLAQQDRAWvgsrqaaVIQVLRKLASRKLTGPKMIELYHCVAETQDLELAR 632
Cdd:pfam17776 78 KLSSEIKQE-------LLQWIKSLIQKELSSERFLNLFHCLYELQDESFVK 121
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
977-1277 |
2.82e-06 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.59 E-value: 2.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 977 HNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMD--AVFSLVQCLSSLQWVFHLDVSlesDCIFLrgagt 1054
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLQELDLS---DNALG----- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1055 srdalepkfQTGVQVLE-LSQRYTSRSFCLQECQLEPTSLTFLCAtlekspGPLEVQLSCKSLsddslkILLQCLpqlpq 1133
Cdd:cd00116 95 ---------PDGCGVLEsLLRSSSLQELKLNNNGLGDRGLRLLAK------GLKDLPPALEKL------VLGRNR----- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1134 lsllqlrhtvLSSRSPFLLADIFNLCPRVRKVTL----------RSLCHAVLHFdsneeQEGVCCGFPGCSLSQEHMETL 1203
Cdd:cd00116 149 ----------LEGASCEALAKALRANRDLKELNLanngigdagiRALAEGLKAN-----CNLEVLDLNNNGLTDEGASAL 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568957139 1204 CCALSKCNALSQLDLTDNLLGDIGLRCLLECLPQLPIS-GWLDLSHNNISQEGILYLLETLPSYPNIQEVSVSLS 1277
Cdd:cd00116 214 AETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISlLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
1574-1642 |
2.74e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 43.28 E-value: 2.74e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568957139 1574 PELRKFDLSHNQIGDVGTQCLAailpKLPELRKFNLSHNQIGHVGTQCLAailpKLPELRKFDLSRNQI 1642
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFK----GLSNLKVLDLSNNLLTTLSPGAFS----GLPSLRYLDLSGNRL 61
|
|
| AvrBs3 |
NF041308 |
type III secretion system effector avirulence protein AvrBs3; |
1535-1737 |
1.15e-03 |
|
type III secretion system effector avirulence protein AvrBs3;
Pssm-ID: 469205 [Multi-domain] Cd Length: 1179 Bit Score: 44.18 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1535 LALLIQGLSRMTLLQDLCLSHNqigDVGTQCLAAILPKLPELRK--FDLSHNQIGDV-----GTQCLAAILPKLPELRK- 1606
Cdd:NF041308 665 LPVLCQRPHGLTPHQVVAIASN---DGGKQALETVQRLLPVLCQppYGLTPEQVVAIasnngGKQALETVQRLLPVLCQr 741
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1607 -FNLSHNQI----GHVG-TQCLAAILPKLPELRK--FDLSRNQI-----GDVGTQCLAAILPKLPELRK--FDLS----- 1666
Cdd:NF041308 742 pHGLTPDQVvaiaSNDGgKQALETVQRLLPVLCQppHGLTPDQVvaiasNDGGKQALETVQRLLPVLCDapHGLTphqvv 821
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1667 --GNRIGPAGGVQLVKSL------THFEHLEEIKLGNNALGEPTALELAQRLPPqlrVLCLPSSHLGPEGALGLA----- 1733
Cdd:NF041308 822 aiASNIGGRQALETVQRLlpvlcqAHGLTPDQVVAIASNNGGKQALETVQRLLP---VLCQPPHGLTPHQVVAIAsnigg 898
|
....*
gi 568957139 1734 -QALE 1737
Cdd:NF041308 899 kQALE 903
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1198-1281 |
1.69e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 42.85 E-value: 1.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1198 EHMETLCCALSKCNALSQLDLTDNLLGDIGLRCLLECLPQLPISGWLDLSHNNISQEGILYLLETLPSYPNIQevSVSLS 1277
Cdd:COG5238 223 EGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLT--SLDLS 300
|
....
gi 568957139 1278 SEQI 1281
Cdd:COG5238 301 VNRI 304
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
957-1263 |
3.98e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 41.70 E-value: 3.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 957 GFLAKHTETLCEALRASCQTHNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMDAVFSLVQCLSSLQWVF 1036
Cdd:COG5238 160 GLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLT 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1037 HLDVSleSDCIFLRGAGTSRDALepKFQTGVQVLELSQRytsrsfclqecQLEPTSLTFLCATLEKSPGPLEVQLSCKSL 1116
Cdd:COG5238 240 TLDLS--NNQIGDEGVIALAEAL--KNNTTVETLYLSGN-----------QIGAEGAIALAKALQGNTTLTSLDLSVNRI 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1117 SDDSLKILLQclpqlpqlsllqlrhtvlssrspfLLAdifnlcprvRKVTLRSLCHAvlhfdsneeqegvccgfpGCSLS 1196
Cdd:COG5238 305 GDEGAIALAE------------------------GLQ---------GNKTLHTLNLA------------------YNGIG 333
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568957139 1197 QEHMETLCCALSKCNALSQLDLTDNLLGDIGLRCLLECLPQLPISGWLDLSHNNISQEGILYLLETL 1263
Cdd:COG5238 334 AQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL 400
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
1600-1871 |
8.01e-03 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 41.37 E-value: 8.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1600 KLPELRKFNLSHNQIGhvgTQCLAAILPKLPELRKFDLSRNQigdvgtqcLAAILPK--LPELRKFDLSGNRIGPaggvQ 1677
Cdd:PLN00113 91 RLPYIQTINLSNNQLS---GPIPDDIFTTSSSLRYLNLSNNN--------FTGSIPRgsIPNLETLDLSNNMLSG----E 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1678 LVKSLTHFEHLEEIKLGNNALGEPTALELAQRlpPQLRVLCLPSSHLgpegALGLAQALEQCPHIEEVSLAENNLAGGVP 1757
Cdd:PLN00113 156 IPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNL--TSLEFLTLASNQL----VGQIPRELGQMKSLKWIYLGYNNLSGEIP 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1758 RFSKRLPLLRQIDLEFCKIEDQAARHLaANLT----LFPALEKL-------------LLSGNLLGDEVAAELAQVLPQMG 1820
Cdd:PLN00113 230 YEIGGLTSLNHLDLVYNNLTGPIPSSL-GNLKnlqyLFLYQNKLsgpippsifslqkLISLDLSDNSLSGEIPELVIQLQ 308
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 568957139 1821 QLKKVNLEWNRITARgaqlLAQGLVQGSCVPVIRLWNNPILNDVAQSLQSQ 1871
Cdd:PLN00113 309 NLEILHLFSNNFTGK----IPVALTSLPRLQVLQLWSNKFSGEIPKNLGKH 355
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Atypical_Card |
pfam18461 |
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts ... |
1-94 |
6.17e-48 |
|
Atypical caspase recruitment domain; The N-terminal effector domain found in NLRC5. It adopts a six alpha-helix bundle with a general death fold. Structure and sequence analysis of the NLRC5-N indicate that it possesses a fold similar to the one of the death-fold domains; however, it displays significant differences in the number of core alpha-helices and their relative orientation. Hence, it is suggested that NLRC5 belongs to the caspase recruitment domain (CARD) subfamily as an atypical CARD.
Pssm-ID: 436519 Cd Length: 95 Bit Score: 165.97 E-value: 6.17e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1 MDAESIRLNNENLWAWLVRLLSKNPEWLSAKLRSFLPTMDLDCSYEPSNP-EVIHRQLNRLFAQGMATWKSFINDLCFEL 79
Cdd:pfam18461 1 MDPESLQLGTENLWPWLVRLLSKNPEWLSAKVKFFLPNMDLGSSNEAPDPtQKVILQLDRLEAQGLATWQSFIHCVCMEL 80
|
90
....*....|....*
gi 568957139 80 DVPLDMEIPLVSIWG 94
Cdd:pfam18461 81 EVPLDLEVPLLSTWG 95
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1566-1875 |
2.73e-34 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 138.00 E-value: 2.73e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1566 LAAILPKLPELRKFDLSHNQIGDVGTQCL-AAILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGD 1644
Cdd:COG5238 143 LIQVLKDPLGGNAVHLLGLAARLGLLAAIsMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGD 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1645 VGTQCLAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTALELAQRL--PPQLRVLCLPSS 1722
Cdd:COG5238 223 EGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALqgNTTLTSLDLSVN 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1723 HLGPEGALGLAQALEQCPHIEEVSLAENNlaggvprfskrlpllrqidlefckIEDQAARHLAANLTLFPALEKLLLSGN 1802
Cdd:COG5238 303 RIGDEGAIALAEGLQGNKTLHTLNLAYNG------------------------IGAQGAIALAKALQENTTLHSLDLSDN 358
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568957139 1803 LLGDEVAAELAQVLPQMGQLKKVNLEWNRITARGAQLLAQGLvQGSCVPVIRLWNNPILNDVAQSLQSQEPRL 1875
Cdd:COG5238 359 QIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQQRLEQLLERI 430
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1490-1745 |
2.51e-33 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 135.30 E-value: 2.51e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1490 HHLEELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGASSLALLIQGLSRMTLLQDLCLSHNQIGDVGTQCLAAI 1569
Cdd:COG5238 180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1570 LPKLPELRKFDLSHNQIGDVGTQCLAAILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGDVGTQC 1649
Cdd:COG5238 260 LKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIA 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1650 LAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTALELAQRL-PPQLRVLCLPSSHLGPEG 1728
Cdd:COG5238 340 LAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALqTNRLHTLILDGNLIGAEA 419
|
250
....*....|....*..
gi 568957139 1729 AlglAQALEQCPHIEEV 1745
Cdd:COG5238 420 Q---QRLEQLLERIKSV 433
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1490-1752 |
4.81e-31 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 125.55 E-value: 4.81e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1490 HHLEELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGAS--SLALLIQGLSRMTLLQDLCLSHNQIGDVGTQCLA 1567
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLE 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1568 AILpKLPELRKFDLSHNQIGDVGTQCLAAILPKLPE-LRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGDVG 1646
Cdd:cd00116 103 SLL-RSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1647 TQCLAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTALELAQRLP---PQLRVLCLPSSH 1723
Cdd:cd00116 182 IRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLspnISLLTLSLSCND 261
|
250 260
....*....|....*....|....*....
gi 568957139 1724 LGPEGALGLAQALEQCPHIEEVSLAENNL 1752
Cdd:cd00116 262 ITDDGAKDLAEVLAEKESLLELDLRGNKF 290
|
|
| NACHT |
pfam05729 |
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ... |
223-385 |
9.25e-31 |
|
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.
Pssm-ID: 428606 [Multi-domain] Cd Length: 166 Bit Score: 119.72 E-value: 9.25e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 223 RVTVLLGKAGMGKTTLAYRLRWRWAQGQLDR-FQALFLFEFRQLNMITQLPTLPQLLFDLYLMPESEPDAVFQYLKENAQ 301
Cdd:pfam05729 1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQgFDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 302 EVLLIFDGLDEALHADSVgTDNAGSALTLFSELCHGNLLPGCWVMTTSRPG---KLPSCVPtEAATVHMWGFDGLRVEKY 378
Cdd:pfam05729 81 RLLLILDGLDELVSDLGQ-LDGPCPVLTLLSSLLRKKLLPGASLLLTVRPDalrDLRRGLE-EPRYLEVRGFSESDRKQY 158
|
....*..
gi 568957139 379 VTCFFSD 385
Cdd:pfam05729 159 VRKYFSD 165
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1492-1738 |
4.07e-28 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 117.07 E-value: 4.07e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1492 LEELDFSNNSLREED--TELLMGALQGTCRLKKLHLSFLPLGASSLALLiQGLSRMTLLQDLCLSHNQIGDVGTQCLAAI 1569
Cdd:cd00116 53 LKELCLSLNETGRIPrgLQSLLQGLTKGCGLQELDLSDNALGPDGCGVL-ESLLRSSSLQELKLNNNGLGDRGLRLLAKG 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1570 LPKLPE-LRKFDLSHNQIGDVGTQCLAAILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGDVGTQ 1648
Cdd:cd00116 132 LKDLPPaLEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGAS 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1649 CLAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEH-LEEIKLGNNALGEPTALELAQRLP--PQLRVLCLPSSHLG 1725
Cdd:cd00116 212 ALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNIsLLTLSLSCNDITDDGAKDLAEVLAekESLLELDLRGNKFG 291
|
250
....*....|...
gi 568957139 1726 PEGALGLAQALEQ 1738
Cdd:cd00116 292 EEGAQLLAESLLE 304
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1548-1857 |
1.63e-27 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 115.15 E-value: 1.63e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1548 LQDLCLSHNQIGDVGTQCLAAILPKLPELRKFDLSHNQIG--DVGTQCLAAILPKLPELRKFNLSHNQIGHVGTQCLAAI 1625
Cdd:cd00116 25 LQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1626 LpKLPELRKFDLSRNQIGDVGTQCLAAILPKLPE-LRKFDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTAL 1704
Cdd:cd00116 105 L-RSSSLQELKLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1705 ELAQRLP--PQLRVLCLPSSHLGPEGALGLAQALEQcphieevslaennlaggvprfskrLPLLRQIDLEFCKIEDQAAR 1782
Cdd:cd00116 184 ALAEGLKanCNLEVLDLNNNGLTDEGASALAETLAS------------------------LKSLEVLNLGDNNLTDAGAA 239
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568957139 1783 HLA-ANLTLFPALEKLLLSGNLLGDEVAAELAQVLPQMGQLKKVNLEWNRITARGAQLLAQGLVQGSCVPvIRLWN 1857
Cdd:cd00116 240 ALAsALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNEL-ESLWV 314
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1415-1686 |
3.17e-26 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 114.12 E-value: 3.17e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1415 LETEHSHLMIQLVETYARLQQLSLSQVSFNDN--DGTSSKLLQNILLSSCELKSFRLTFSQVSTKSLTHLAFGLGHCHHL 1492
Cdd:COG5238 159 LGLAARLGLLAAISMAKALQNNSVETVYLGCNqiGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSL 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1493 EELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGASSLALLIQGLSRMTLLQDLCLSHNQIGDVGTQCLAAILPK 1572
Cdd:COG5238 239 TTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1573 LPELRKFDLSHNQIGDVGTQCLAAILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGDVGTQCLAA 1652
Cdd:COG5238 319 NKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALID 398
|
250 260 270
....*....|....*....|....*....|....
gi 568957139 1653 ILpKLPELRKFDLSGNRIGPAGGVQLVKSLTHFE 1686
Cdd:COG5238 399 AL-QTNRLHTLILDGNLIGAEAQQRLEQLLERIK 431
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1407-1654 |
1.89e-25 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 109.37 E-value: 1.89e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1407 ALRLAHCDLETEHS----HLMIQLVETYARLQQLSLSQVSFNDndgTSSKLLQNILLSScELKSFRLTFSQVSTKSLTHL 1482
Cdd:cd00116 53 LKELCLSLNETGRIprglQSLLQGLTKGCGLQELDLSDNALGP---DGCGVLESLLRSS-SLQELKLNNNGLGDRGLRLL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1483 AFGLGHC-HHLEELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGASSLALLIQGLSRMTLLQDLCLSHNQIGDV 1561
Cdd:cd00116 129 AKGLKDLpPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1562 GTQCLAAILPKLPELRKFDLSHNQIGDVGTQCLAAILPKL-PELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRN 1640
Cdd:cd00116 209 GASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPnISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
250
....*....|....
gi 568957139 1641 QIGDVGTQCLAAIL 1654
Cdd:cd00116 289 KFGEEGAQLLAESL 302
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
223-955 |
6.27e-23 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 106.81 E-value: 6.27e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 223 RVTVLLGKAGMGKTTLAYRLRWRWAQGQLDRFQAL-FLFEFRQLNmitQLPTLPQLLFDLYLMPESEPDAVFQYLKENAQ 301
Cdd:COG5635 181 KRLLILGEPGSGKTTLLRYLALELAERYLDAEDPIpILIELRDLA---EEASLEDLLAEALEKRGGEPEDALERLLRNGR 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 302 eVLLIFDGLDEAlhADSVGTDNAGSALTLFSELChgnllPGCWVMTTSRPGKLPSCVPTEAATVHMWGFDGLRVEKYVTC 381
Cdd:COG5635 258 -LLLLLDGLDEV--PDEADRDEVLNQLRRFLERY-----PKARVIITSRPEGYDSSELEGFEVLELAPLSDEQIEEFLKK 329
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 382 FFSDLLSQ-ELALKEMRTNARLRGMCAIPALCTVTCFCLRrllpgsspgQSAALLPTITQLYLQMVETF---------SP 451
Cdd:COG5635 330 WFEATERKaERLLEALEENPELRELARNPLLLTLLALLLR---------ERGELPDTRAELYEQFVELLlerwdeqrgLT 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 452 SETLLDTSILG--FGKVALRGLDTGKVVFSVED----ISPQLMSFGAVHSLLTSFCIHT----RPGHEEigYAFVHLSLQ 521
Cdd:COG5635 401 IYRELSREELRelLSELALAMQENGRTEFAREEleeiLREYLGRRKDAEALLDELLLRTgllvERGEGR--YSFAHRSFQ 478
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 522 EFFAALYLMASHTVD-KDTLVEYVTlNSHW---VLRTKGRLGLSDHLPAFLAGLASHTCHMFLCQLAQQDRAWVGSRQAA 597
Cdd:COG5635 479 EYLAARALVEELDEElLELLAEHLE-DPRWrevLLLLAGLLDDVKQIKELIDALLARDDAAALALAAALLLALLLALALL 557
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 598 VIQVLRKLASRKLTGPKMIELYHCVAETQDLELARFTAQSLPSRLSFHNFPLTHADLAALANILEHRDDPIHLDFDGCPL 677
Cdd:COG5635 558 ALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALLLALLLLLLLLLLAELL 637
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 678 EPHCPEALVGCGQVENLSFKSRKCGDAFAEALCRSLPTMGSLKTLGLTGSRITAQGISHLIQTLPLCSQLEEVSLHD-NQ 756
Cdd:COG5635 638 LLALLALVLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAELLLALLALASLLLLLLLALALALALLLLAVLLAAaLD 717
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 757 LKDPEVLSLVELLPSLPKLQKLEELDLIFYLSPVTETATQQSGASDVQGKDSLKEGQSRSLQLRLQKCQLRIRDAEALVE 836
Cdd:COG5635 718 LLLLLVLLLALLLVLALALSLLLLALALLLAGALLLESSALLAVLLASLLLALLLLSLLLLLVLLLALALLASLLLALLL 797
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 837 LFQKSPQLEEVNLSGNHLEDDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTYVLKAMSTCGTLEDLHISLLNNTVVLTF 916
Cdd:COG5635 798 LILLLVLLGSLLLLRLLDDLALLLLLALAAARLLLSSLALVALELARASLGASLVLLALLLATLLLLLLLLLALALALLS 877
|
730 740 750
....*....|....*....|....*....|....*....
gi 568957139 917 AQEPREQEGSCKGRAPLISFVSPVTSELSQRSRRIRLTH 955
Cdd:COG5635 878 LLSLSSLALLSLLGLLLALSLLALLLLSLSLALAALLLA 916
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
1597-1868 |
2.94e-21 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 97.04 E-value: 2.94e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1597 ILPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIG--DVGTQCLAAILPKLPELRKFDLSGNRIGPAG 1674
Cdd:cd00116 18 LLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALGPDG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1675 gVQLVKSLTHFEHLEEIKLGNNALGePTALELAQR----LPPQLRVLCLPSSHLGPEGALGLAQALEQCPHIEEVSLAEN 1750
Cdd:cd00116 98 -CGVLESLLRSSSLQELKLNNNGLG-DRGLRLLAKglkdLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANN 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1751 NlaggvprfskrlpllrqidlefckIEDQAARHLAANLTLFPALEKLLLSGNLLGDEVAAELAQVLPQMGQLKKVNLEWN 1830
Cdd:cd00116 176 G------------------------IGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDN 231
|
250 260 270
....*....|....*....|....*....|....*....
gi 568957139 1831 RITARGAQLLAQGLVQGS-CVPVIRLWNNPILNDVAQSL 1868
Cdd:cd00116 232 NLTDAGAAALASALLSPNiSLLTLSLSCNDITDDGAKDL 270
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1378-1728 |
4.69e-17 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 85.76 E-value: 4.69e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1378 LTELSISEIQRKLWLQLEFPHQEGNSDSMALRLAHCDLETEHSHLMIQLVETYARLQQLSLSQVSFNDNDGTSS-KLLQN 1456
Cdd:COG4886 38 LLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNlTNLES 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1457 ILLSSCELKSFRLTFSQ--------VSTKSLTHLAFGLGHCHHLEELDFSNNSLREEDTELlmGALQgtcRLKKLHLSFL 1528
Cdd:COG4886 118 LDLSGNQLTDLPEELANltnlkeldLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEEL--GNLT---NLKELDLSNN 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1529 PLgaSSLALLIQGLSRmtlLQDLCLSHNQIGDvgtqcLAAILPKLPELRKFDLSHNQIGDVgtqclaAILPKLPELRKFN 1608
Cdd:COG4886 193 QI--TDLPEPLGNLTN---LEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQLTDL------PELGNLTNLEELD 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1609 LSHNQIGHVGTqclaaiLPKLPELRKFDLSRNQIGDVGTQCLAAILPKLPELRKFDLSGNRIGPAGGVQLVKSLTHFEHL 1688
Cdd:COG4886 257 LSNNQLTDLPP------LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLL 330
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 568957139 1689 EEIKLGNNALGEPTALELAQRLPPQLRVLCLPSSHLGPEG 1728
Cdd:COG4886 331 KGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLG 370
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
640-906 |
4.33e-15 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 79.83 E-value: 4.33e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 640 SRLSFHNFPLTHADLAALANILEHRDDPI--HLDFDGCP-----LEPHCPEALVGCGQVENLSFKSRKCGDAFAEALCRS 712
Cdd:COG5238 124 AKTLEDSLILYLALPRRINLIQVLKDPLGgnAVHLLGLAarlglLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEA 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 713 LPTMGSLKTLGLTGSRITAQGISHLIQTLPLCSQLEEVSLHDNQLKDPEVLSLVELLpslpKLQK-LEELDLifYLSPVT 791
Cdd:COG5238 204 LTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEAL----KNNTtVETLYL--SGNQIG 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 792 ETaTQQSGASDVQGKDSLKegqsrSLQLRLQkcQLRIRDAEALVELFQKSPQLEEVNLSGNHLEDDGCRLVAEAASQLHI 871
Cdd:COG5238 278 AE-GAIALAKALQGNTTLT-----SLDLSVN--RIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTT 349
|
250 260 270
....*....|....*....|....*....|....*
gi 568957139 872 AQKLDLSDNGLSQTGVTYVLKAMSTCGTLEDLHIS 906
Cdd:COG5238 350 LHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLG 384
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1492-1885 |
1.79e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 77.67 E-value: 1.79e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1492 LEELDFSNNSLREEDTELLMGALQGTCRLKKLHLSFLPLGASSLALLIQGLSRMTLLQDLCLSHNQIGDVGTQCLAAILP 1571
Cdd:COG4886 14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1572 KLPELRKFDLSHNQIgdvgtqclaaiLPKLPELRKFNLSHNQIGHvgtqcLAAILPKLPELRKFDLSRNQIGDVGTQcla 1651
Cdd:COG4886 94 DLTNLTELDLSGNEE-----------LSNLTNLESLDLSGNQLTD-----LPEELANLTNLKELDLSNNQLTDLPEP--- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1652 aiLPKLPELRKFDLSGNRIGpaggvQLVKSLTHFEHLEEIKLGNNALGEptalelaqrlppqlrvlclpsshlgpegalg 1731
Cdd:COG4886 155 --LGNLTNLKSLDLSNNQLT-----DLPEELGNLTNLKELDLSNNQITD------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1732 LAQALEQCPHIEEVSLAENNLAGgVPRFSKRLPLLRQIDLEFCKIEDqaarhlAANLTLFPALEKLLLSGNLLGDevaae 1811
Cdd:COG4886 197 LPEPLGNLTNLEELDLSGNQLTD-LPEPLANLTNLETLDLSNNQLTD------LPELGNLTNLEELDLSNNQLTD----- 264
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568957139 1812 laqvLP---QMGQLKKVNLEWNRITARGAQLLAQGLVQGSCVPVIRLWNNPILNDVAQSLQSQEPRLDFSITDQQTL 1885
Cdd:COG4886 265 ----LPplaNLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
831-1029 |
3.64e-13 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 74.06 E-value: 3.64e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 831 AEALVELFQKSPQLEEVNLSGNHLEDDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTYVLKAMSTCGTLEDLHISLlNN 910
Cdd:COG5238 225 AEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSV-NR 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 911 tvvLTFAqepreqegSCKGRAPLISFVSPVTSelsqrsrrIRLTHCGFLAKHTETLCEALRASCQTHNLDhldLSDNSLG 990
Cdd:COG5238 304 ---IGDE--------GAIALAEGLQGNKTLHT--------LNLAYNGIGAQGAIALAKALQENTTLHSLD---LSDNQIG 361
|
170 180 190
....*....|....*....|....*....|....*....
gi 568957139 991 GKGVILLTELLPGLGPLKSLNLSRNGLSMDAVFSLVQCL 1029
Cdd:COG5238 362 DEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL 400
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
683-896 |
6.01e-13 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 73.29 E-value: 6.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 683 EALVGCGQVENLSFKSRKCGDAFAEALCRSLPTMGSLKTLGLTGSRITAQGISHLIQTLPLCSQLEEVSLHDNQLKDPEV 762
Cdd:COG5238 230 EALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGA 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 763 LSLVEllpSLPKLQKLEELDLifylspvtetatqqsgASdvqgkdslkegqsrslqlrlqkCQLRIRDAEALVELFQKSP 842
Cdd:COG5238 310 IALAE---GLQGNKTLHTLNL----------------AY----------------------NGIGAQGAIALAKALQENT 348
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 568957139 843 QLEEVNLSGNHLEDDGCRLVAEA---ASQLHiaqKLDLSDNGLSQTGVTYVLKAMST 896
Cdd:COG5238 349 TLHSLDLSDNQIGDEGAIALAKYlegNTTLR---ELNLGKNNIGKQGAEALIDALQT 402
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
611-865 |
1.02e-12 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 71.23 E-value: 1.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 611 TGPKMIELYHCVAETQDLELARFtaQSLPSRLSFHNFPLTHADLaalanilehrdDPIHLDFDGCPLePHCPEAL--VGC 688
Cdd:cd00116 79 KGCGLQELDLSDNALGPDGCGVL--ESLLRSSSLQELKLNNNGL-----------GDRGLRLLAKGL-KDLPPALekLVL 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 689 GQvenlsfksRKCGDAFAEALCRSLPTMGSLKTLGLTGSRITAQGISHLIQTLPLCSQLEEVSLHDNQLKDPEVLSLVEL 768
Cdd:cd00116 145 GR--------NRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAET 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 769 LPSLPKLQKLEELDlifylSPVTETatqqsGASDVqgKDSLKEGQSRSLQLRLQKCQLRIRDAEALVELFQKSPQLEEVN 848
Cdd:cd00116 217 LASLKSLEVLNLGD-----NNLTDA-----GAAAL--ASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELD 284
|
250
....*....|....*..
gi 568957139 849 LSGNHLEDDGCRLVAEA 865
Cdd:cd00116 285 LRGNKFGEEGAQLLAES 301
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
1433-1717 |
5.67e-12 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 69.96 E-value: 5.67e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1433 LQQLSLSQVSFNDNDGTSSKL--LQNILLSSCELKSFRLTFSQ--------VSTKSLTHLAFGLGHCHHLEELDFSNNSL 1502
Cdd:COG4886 115 LESLDLSGNQLTDLPEELANLtnLKELDLSNNQLTDLPEPLGNltnlksldLSNNQLTDLPEELGNLTNLKELDLSNNQI 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1503 REEDTELlmGALQgtcRLKKLHLSflplgASSLALLIQGLSRMTLLQDLCLSHNQIGDVgtqclaAILPKLPELRKFDLS 1582
Cdd:COG4886 195 TDLPEPL--GNLT---NLEELDLS-----GNQLTDLPEPLANLTNLETLDLSNNQLTDL------PELGNLTNLEELDLS 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1583 HNQIGDVGTqclaaiLPKLPELRKFNLSHNQIGHVGTQCLAAILPKLPELRKFDLSRNQIGDVGTQCLAAILPKLPELRK 1662
Cdd:COG4886 259 NNQLTDLPP------LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 568957139 1663 FDLSGNRIGPAGGVQLVKSLTHFEHLEEIKLGNNALGEPTALELAQRLPPQLRVL 1717
Cdd:COG4886 333 LLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLL 387
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
818-1088 |
3.32e-11 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 66.61 E-value: 3.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 818 QLRLQKCQLRIRDAEALVELFQKSPQLEEVNLSGNHLE--DDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTyVLKAMS 895
Cdd:cd00116 27 VLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCG-VLESLL 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 896 TCGTLEDLHisLLNNTvvLTFAQEPREQEGSCKGRAPLISFV-----------SPVTSELS--QRSRRIRLTHCGFLAKH 962
Cdd:cd00116 106 RSSSLQELK--LNNNG--LGDRGLRLLAKGLKDLPPALEKLVlgrnrlegascEALAKALRanRDLKELNLANNGIGDAG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 963 TETLCEALRASCqthNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMDAVFSLVQCLSSLQWVFhLDVSL 1042
Cdd:cd00116 182 IRALAEGLKANC---NLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISL-LTLSL 257
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 568957139 1043 ESDCIFLRGAGTSRDALEPKFQtgVQVLELSQRYTSRSFCLQECQL 1088
Cdd:cd00116 258 SCNDITDDGAKDLAEVLAEKES--LLELDLRGNKFGEEGAQLLAES 301
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1477-1670 |
1.45e-10 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 62.88 E-value: 1.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1477 KSLTHLAF---------GLGHCHHLEELDFSNNSLREedtellMGALQGTCRLKKLHLS--FLplgaSSlallIQGLSRM 1545
Cdd:cd21340 2 KRITHLYLndknitkidNLSLCKNLKVLYLYDNKITK------IENLEFLTNLTHLYLQnnQI----EK----IENLENL 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1546 TLLQDLCLSHNQIGDV-GtqclaaiLPKLPELRKFDLSHNQIGD-----VGTQCLAAIlpkLPELRKFNLSHNQIghvgt 1619
Cdd:cd21340 68 VNLKKLYLGGNRISVVeG-------LENLTNLEELHIENQRLPPgekltFDPRSLAAL---SNSLRVLNISGNNI----- 132
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 568957139 1620 QCLAAILPkLPELRKFDLSRNQIGDVgtQCLAAILPKLPELRKFDLSGNRI 1670
Cdd:cd21340 133 DSLEPLAP-LRNLEQLDASNNQISDL--EELLDLLSSWPSLRELDLTGNPV 180
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
775-1041 |
5.12e-10 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 64.04 E-value: 5.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 775 LQKLEELDLIFYLSPVTETATQQSGASDVQGKDSLKEGQSRSLQlrlqkcqlriRDAEALVELFQKSPQLEEVNLSGNHL 854
Cdd:COG5238 123 MAKTLEDSLILYLALPRRINLIQVLKDPLGGNAVHLLGLAARLG----------LLAAISMAKALQNNSVETVYLGCNQI 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 855 EDDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTYVLKAMSTCGTLEDLHISllNNTVvltfaqepreqegSCKGRAPLI 934
Cdd:COG5238 193 GDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLS--NNQI-------------GDEGVIALA 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 935 sfvspvtsELSQRSRRIR---LTHCGFLAKHTETLCEALRASCQTHNLDhldLSDNSLGGKGVILLTELLPGLGPLKSLN 1011
Cdd:COG5238 258 --------EALKNNTTVEtlyLSGNQIGAEGAIALAKALQGNTTLTSLD---LSVNRIGDEGAIALAEGLQGNKTLHTLN 326
|
250 260 270
....*....|....*....|....*....|
gi 568957139 1012 LSRNGLSMDAVFSLVQCLSSLQWVFHLDVS 1041
Cdd:COG5238 327 LAYNGIGAQGAIALAKALQENTTLHSLDLS 356
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
817-1126 |
7.52e-10 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 62.37 E-value: 7.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 817 LQLRLQKCQLRIRDAEalvELFQKSPQLEEVNLSGNHLEDDGCRLVAEAASQLHIAQKLDLSDN--GLSQTGVTYVLKAM 894
Cdd:cd00116 1 LQLSLKGELLKTERAT---ELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNetGRIPRGLQSLLQGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 895 STCGTLEdlHISLLNNTvvLTFAqepreqegsckGRAPLISFVSPVTSELSQrsrrirLTHCGFLAKHTETLCEALRaSC 974
Cdd:cd00116 78 TKGCGLQ--ELDLSDNA--LGPD-----------GCGVLESLLRSSSLQELK------LNNNGLGDRGLRLLAKGLK-DL 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 975 QtHNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMDAVFSLVQCLSSLQWVFHLDvsLESDCIFLRGAGT 1054
Cdd:cd00116 136 P-PALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLD--LNNNGLTDEGASA 212
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568957139 1055 SRDALEPKFQtgVQVLELSQrytsrsfCLqeCQLEPTSlTFLCATLEKSPGPLEVQLSCKSLSDDSLKILLQ 1126
Cdd:cd00116 213 LAETLASLKS--LEVLNLGD-------NN--LTDAGAA-ALASALLSPNISLLTLSLSCNDITDDGAKDLAE 272
|
|
| NLRC4_HD2 |
pfam17776 |
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ... |
517-632 |
2.20e-09 |
|
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.
Pssm-ID: 465499 [Multi-domain] Cd Length: 122 Bit Score: 56.92 E-value: 2.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 517 HLSLQEFFAALYLMASHTVDKDTLV----------EYVTLNSHWVLRTKGRLglsDHLPAFLAGLASHTCHMFL-----C 581
Cdd:pfam17776 1 HLSFQEFFAALFYVLSFKEEKSNPLkeffglrkreSLKSLLDKALKSKNGHL---DLFLRFLFGLLNEENQRLLegllgC 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 568957139 582 QLAQQDRAWvgsrqaaVIQVLRKLASRKLTGPKMIELYHCVAETQDLELAR 632
Cdd:pfam17776 78 KLSSEIKQE-------LLQWIKSLIQKELSSERFLNLFHCLYELQDESFVK 121
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
706-1015 |
3.01e-07 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 54.28 E-value: 3.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 706 AEALCRSLPTMGSLKTLGL----TGSRITAQGIshLIQTLPLCSQLEEVSLHDNQLKDpevlSLVELLPSLPKLQKLEEL 781
Cdd:cd00116 40 AKALASALRPQPSLKELCLslneTGRIPRGLQS--LLQGLTKGCGLQELDLSDNALGP----DGCGVLESLLRSSSLQEL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 782 DLifylspvtetatQQSGASDVQGK---DSLKEGQSRSLQLRLQKCQLRIRDAEALVELFQKSPQLEEVNLSGNHL---- 854
Cdd:cd00116 114 KL------------NNNGLGDRGLRllaKGLKDLPPALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIgdag 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 855 ------------------------EDDGCRLVAEAASQLHIAQKLDLSDNGLSQTGVTYVLKAMSTcgtledlhisllnn 910
Cdd:cd00116 182 iralaeglkancnlevldlnnnglTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLS-------------- 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 911 tvvltfaqepreqegsckgraplisfvspvtseLSQRSRRIRLTHCGFLAKHTETLCEALRASCQthnLDHLDLSDNSLG 990
Cdd:cd00116 248 ---------------------------------PNISLLTLSLSCNDITDDGAKDLAEVLAEKES---LLELDLRGNKFG 291
|
330 340
....*....|....*....|....*.
gi 568957139 991 GKGVILLTELLPGLGP-LKSLNLSRN 1015
Cdd:cd00116 292 EEGAQLLAESLLEPGNeLESLWVKDD 317
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
977-1277 |
2.82e-06 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.59 E-value: 2.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 977 HNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMD--AVFSLVQCLSSLQWVFHLDVSlesDCIFLrgagt 1054
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIprGLQSLLQGLTKGCGLQELDLS---DNALG----- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1055 srdalepkfQTGVQVLE-LSQRYTSRSFCLQECQLEPTSLTFLCAtlekspGPLEVQLSCKSLsddslkILLQCLpqlpq 1133
Cdd:cd00116 95 ---------PDGCGVLEsLLRSSSLQELKLNNNGLGDRGLRLLAK------GLKDLPPALEKL------VLGRNR----- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1134 lsllqlrhtvLSSRSPFLLADIFNLCPRVRKVTL----------RSLCHAVLHFdsneeQEGVCCGFPGCSLSQEHMETL 1203
Cdd:cd00116 149 ----------LEGASCEALAKALRANRDLKELNLanngigdagiRALAEGLKAN-----CNLEVLDLNNNGLTDEGASAL 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568957139 1204 CCALSKCNALSQLDLTDNLLGDIGLRCLLECLPQLPIS-GWLDLSHNNISQEGILYLLETLPSYPNIQEVSVSLS 1277
Cdd:cd00116 214 AETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISlLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGN 288
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
1574-1642 |
2.74e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 43.28 E-value: 2.74e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568957139 1574 PELRKFDLSHNQIGDVGTQCLAailpKLPELRKFNLSHNQIGHVGTQCLAailpKLPELRKFDLSRNQI 1642
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFK----GLSNLKVLDLSNNLLTTLSPGAFS----GLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
1602-1670 |
8.00e-05 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 42.13 E-value: 8.00e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568957139 1602 PELRKFNLSHNQIGHVGTQCLAailpKLPELRKFDLSRNQIGDVGTQCLAailpKLPELRKFDLSGNRI 1670
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFK----GLSNLKVLDLSNNLLTTLSPGAFS----GLPSLRYLDLSGNRL 61
|
|
| AvrBs3 |
NF041308 |
type III secretion system effector avirulence protein AvrBs3; |
1535-1737 |
1.15e-03 |
|
type III secretion system effector avirulence protein AvrBs3;
Pssm-ID: 469205 [Multi-domain] Cd Length: 1179 Bit Score: 44.18 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1535 LALLIQGLSRMTLLQDLCLSHNqigDVGTQCLAAILPKLPELRK--FDLSHNQIGDV-----GTQCLAAILPKLPELRK- 1606
Cdd:NF041308 665 LPVLCQRPHGLTPHQVVAIASN---DGGKQALETVQRLLPVLCQppYGLTPEQVVAIasnngGKQALETVQRLLPVLCQr 741
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1607 -FNLSHNQI----GHVG-TQCLAAILPKLPELRK--FDLSRNQI-----GDVGTQCLAAILPKLPELRK--FDLS----- 1666
Cdd:NF041308 742 pHGLTPDQVvaiaSNDGgKQALETVQRLLPVLCQppHGLTPDQVvaiasNDGGKQALETVQRLLPVLCDapHGLTphqvv 821
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1667 --GNRIGPAGGVQLVKSL------THFEHLEEIKLGNNALGEPTALELAQRLPPqlrVLCLPSSHLGPEGALGLA----- 1733
Cdd:NF041308 822 aiASNIGGRQALETVQRLlpvlcqAHGLTPDQVVAIASNNGGKQALETVQRLLP---VLCQPPHGLTPHQVVAIAsnigg 898
|
....*
gi 568957139 1734 -QALE 1737
Cdd:NF041308 899 kQALE 903
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1198-1281 |
1.69e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 42.85 E-value: 1.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1198 EHMETLCCALSKCNALSQLDLTDNLLGDIGLRCLLECLPQLPISGWLDLSHNNISQEGILYLLETLPSYPNIQevSVSLS 1277
Cdd:COG5238 223 EGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLT--SLDLS 300
|
....
gi 568957139 1278 SEQI 1281
Cdd:COG5238 301 VNRI 304
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1195-1328 |
2.18e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 42.85 E-value: 2.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1195 LSQEHMETLCCALSKCNALSQLDLTDNLLGDIGLRCLLECLPQLPISGWLDLSHNNISQEGILYLLETLPSYPNIqevsv 1274
Cdd:COG5238 276 IGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTL----- 350
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 568957139 1275 slsseqifrmcfskkegagTSLRLCECSFSPEQVSKLASSLSQAQQLTELWLTK 1328
Cdd:COG5238 351 -------------------HSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGK 385
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
1548-1614 |
2.27e-03 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 37.89 E-value: 2.27e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568957139 1548 LQDLCLSHNQIGDVGTQCLAailpKLPELRKFDLSHNQIGDVGTQCLAailpKLPELRKFNLSHNQI 1614
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFK----GLSNLKVLDLSNNLLTTLSPGAFS----GLPSLRYLDLSGNRL 61
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
1171-1657 |
2.61e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 42.47 E-value: 2.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1171 CHAVLHFDSNEEQEGVCCGfpGCSLSQEHMETLCCALSKCNALSQLDLTDNLLGDIGLRCLLECLPQLPISGWLDLSHNN 1250
Cdd:COG5238 170 AISMAKALQNNSVETVYLG--CNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQ 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1251 ISQEGILYLLETLPSypniqevsvslsseqifrmcfskkegaGTSLRlcecsfspeqvsklasslsqaqqltelwltkcH 1330
Cdd:COG5238 248 IGDEGVIALAEALKN---------------------------NTTVE--------------------------------T 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1331 LDLpqltmllnlvnrptgllglrleepwvdsvslpalmevcaqasgcltelsiseiqrklwlqlefphqEGNsdsmalrl 1410
Cdd:COG5238 269 LYL------------------------------------------------------------------SGN-------- 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1411 ahcdletehshlmiqlvetyarlqqlslsqvsfndndgtsskllqnillsscelksfrltfsQVSTKSLTHLAFGLGHCH 1490
Cdd:COG5238 275 --------------------------------------------------------------QIGAEGAIALAKALQGNT 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1491 HLEELDFSNNSLREEdtellmgalqgtcrlkklhlsflplGASSLAlliQGLSRMTLLQDLCLSHNQIGDVGTQCLAAIL 1570
Cdd:COG5238 293 TLTSLDLSVNRIGDE-------------------------GAIALA---EGLQGNKTLHTLNLAYNGIGAQGAIALAKAL 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1571 PKLPELRKFDLSHNQIGDVGTQCLAAILPKLPELRKFNLSHNQIGHVGTQCLAAILpKLPELRKFDLSRNQIGDVGTQCL 1650
Cdd:COG5238 345 QENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL-QTNRLHTLILDGNLIGAEAQQRL 423
|
....*..
gi 568957139 1651 AAILPKL 1657
Cdd:COG5238 424 EQLLERI 430
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
1736-1835 |
3.91e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 40.92 E-value: 3.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1736 LEQCPHIEEVSLAENNLAGGVP-RFSKR-----LPLLRQIDLEFCKIEDqaarhlAANLTLFPALEKLLLSGNLLGDevA 1809
Cdd:cd21340 86 LENLTNLEELHIENQRLPPGEKlTFDPRslaalSNSLRVLNISGNNIDS------LEPLAPLRNLEQLDASNNQISD--L 157
|
90 100
....*....|....*....|....*.
gi 568957139 1810 AELAQVLPQMGQLKKVNLEWNRITAR 1835
Cdd:cd21340 158 EELLDLLSSWPSLRELDLTGNPVCKK 183
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
957-1263 |
3.98e-03 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 41.70 E-value: 3.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 957 GFLAKHTETLCEALRASCQTHNLDHLDLSDNSLGGKGVILLTELLPGLGPLKSLNLSRNGLSMDAVFSLVQCLSSLQWVF 1036
Cdd:COG5238 160 GLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLT 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1037 HLDVSleSDCIFLRGAGTSRDALepKFQTGVQVLELSQRytsrsfclqecQLEPTSLTFLCATLEKSPGPLEVQLSCKSL 1116
Cdd:COG5238 240 TLDLS--NNQIGDEGVIALAEAL--KNNTTVETLYLSGN-----------QIGAEGAIALAKALQGNTTLTSLDLSVNRI 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1117 SDDSLKILLQclpqlpqlsllqlrhtvlssrspfLLAdifnlcprvRKVTLRSLCHAvlhfdsneeqegvccgfpGCSLS 1196
Cdd:COG5238 305 GDEGAIALAE------------------------GLQ---------GNKTLHTLNLA------------------YNGIG 333
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568957139 1197 QEHMETLCCALSKCNALSQLDLTDNLLGDIGLRCLLECLPQLPISGWLDLSHNNISQEGILYLLETL 1263
Cdd:COG5238 334 AQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDAL 400
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
707-883 |
4.50e-03 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 41.46 E-value: 4.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 707 EALCRSLPTMGSLKTLGLTGSRITaqgisHLIQTLPLCSQLEEVSLHDNQLKD-PEVLSlvellpslpKLQKLEELDLif 785
Cdd:COG4886 126 TDLPEELANLTNLKELDLSNNQLT-----DLPEPLGNLTNLKSLDLSNNQLTDlPEELG---------NLTNLKELDL-- 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 786 YLSPVTETAtqqsgasdvqgkDSLkeGQSRSLQ-LRLQKCQLrirdaEALVELFQKSPQLEEVNLSGNHLEDdgcrlvAE 864
Cdd:COG4886 190 SNNQITDLP------------EPL--GNLTNLEeLDLSGNQL-----TDLPEPLANLTNLETLDLSNNQLTD------LP 244
|
170
....*....|....*....
gi 568957139 865 AASQLHIAQKLDLSDNGLS 883
Cdd:COG4886 245 ELGNLTNLEELDLSNNQLT 263
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
710-906 |
5.92e-03 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 41.07 E-value: 5.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 710 CRSLPTMGSLKTLGLTGSRITaqgisHLIQTLPLCSQLEEVSLHDNQLKDpevlslveLLPSLPKLQKLEELDLifylsp 789
Cdd:COG4886 106 NEELSNLTNLESLDLSGNQLT-----DLPEELANLTNLKELDLSNNQLTD--------LPEPLGNLTNLKSLDL------ 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 790 vteTATQQSGASDVQGK-DSLKEgqsrslqLRLQKCQLrirdaEALVELFQKSPQLEEVNLSGNHLEDdgcrlVAEAASQ 868
Cdd:COG4886 167 ---SNNQLTDLPEELGNlTNLKE-------LDLSNNQI-----TDLPEPLGNLTNLEELDLSGNQLTD-----LPEPLAN 226
|
170 180 190
....*....|....*....|....*....|....*...
gi 568957139 869 LHIAQKLDLSDNGLSQtgvtyvLKAMSTCGTLEDLHIS 906
Cdd:COG4886 227 LTNLETLDLSNNQLTD------LPELGNLTNLEELDLS 258
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
1600-1871 |
8.01e-03 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 41.37 E-value: 8.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1600 KLPELRKFNLSHNQIGhvgTQCLAAILPKLPELRKFDLSRNQigdvgtqcLAAILPK--LPELRKFDLSGNRIGPaggvQ 1677
Cdd:PLN00113 91 RLPYIQTINLSNNQLS---GPIPDDIFTTSSSLRYLNLSNNN--------FTGSIPRgsIPNLETLDLSNNMLSG----E 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1678 LVKSLTHFEHLEEIKLGNNALGEPTALELAQRlpPQLRVLCLPSSHLgpegALGLAQALEQCPHIEEVSLAENNLAGGVP 1757
Cdd:PLN00113 156 IPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNL--TSLEFLTLASNQL----VGQIPRELGQMKSLKWIYLGYNNLSGEIP 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 1758 RFSKRLPLLRQIDLEFCKIEDQAARHLaANLT----LFPALEKL-------------LLSGNLLGDEVAAELAQVLPQMG 1820
Cdd:PLN00113 230 YEIGGLTSLNHLDLVYNNLTGPIPSSL-GNLKnlqyLFLYQNKLsgpippsifslqkLISLDLSDNSLSGEIPELVIQLQ 308
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 568957139 1821 QLKKVNLEWNRITARgaqlLAQGLVQGSCVPVIRLWNNPILNDVAQSLQSQ 1871
Cdd:PLN00113 309 NLEILHLFSNNFTGK----IPVALTSLPRLQVLQLWSNKFSGEIPKNLGKH 355
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
669-783 |
8.87e-03 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 40.69 E-value: 8.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568957139 669 HLDFDGCPLEpHCPEALVGCGQVENLSFKSRKCGDaFAEALCRslptMGSLKTLGLTGSRITAqgishLIQTLPLCSQLE 748
Cdd:COG4886 163 SLDLSNNQLT-DLPEELGNLTNLKELDLSNNQITD-LPEPLGN----LTNLEELDLSGNQLTD-----LPEPLANLTNLE 231
|
90 100 110
....*....|....*....|....*....|....*
gi 568957139 749 EVSLHDNQLKDpevlslvelLPSLPKLQKLEELDL 783
Cdd:COG4886 232 TLDLSNNQLTD---------LPELGNLTNLEELDL 257
|
|
| |
