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Conserved domains on  [gi|569007195|ref|XP_006527123|]
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solute carrier family 22. member 29 isoform X2 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 109-454 5.68e-114

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17374:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 341  Bit Score: 339.65  E-value: 5.68e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 109 SEPDTEPCVDGWVYDRSNFLSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITET 188
Cdd:cd17374    1 SEADTEPCVDGWVYDRSKFTSTIVTEWDLVCESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 189 CVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAP 268
Cdd:cd17374   81 CAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 269 IFFFLILTRWLSesarwlilinkpqkglkelrkvahmngmknsgdltmeivrtsmkaeleaaktkpslrdlfhtsilrKR 348
Cdd:cd17374  161 FFLFFLYSWWLP------------------------------------------------------------------KR 174

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 349 ICVLSFIRLFFTVSIIGLAVHLQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQ- 427
Cdd:cd17374  175 TLILSFVWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVPQe 254

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 428 ------------------------------------------------------------ATYYANLPWIFYGGFSIFNA 447
Cdd:cd17374  255 mqtlrtvlavlgkgssaaaftisyvytaelfptvlrqtgmglnsmfariggilaplimllGVYSPLLPMIIYGVLPILAG 334


                 ....*..
gi 569007195 448 FTVFLLP 454
Cdd:cd17374  335 LLALLLP 341
 
Name Accession Description Interval E-value
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 109-454 5.68e-114

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 339.65  E-value: 5.68e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 109 SEPDTEPCVDGWVYDRSNFLSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITET 188
Cdd:cd17374    1 SEADTEPCVDGWVYDRSKFTSTIVTEWDLVCESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 189 CVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAP 268
Cdd:cd17374   81 CAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 269 IFFFLILTRWLSesarwlilinkpqkglkelrkvahmngmknsgdltmeivrtsmkaeleaaktkpslrdlfhtsilrKR 348
Cdd:cd17374  161 FFLFFLYSWWLP------------------------------------------------------------------KR 174

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 349 ICVLSFIRLFFTVSIIGLAVHLQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQ- 427
Cdd:cd17374  175 TLILSFVWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVPQe 254

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 428 ------------------------------------------------------------ATYYANLPWIFYGGFSIFNA 447
Cdd:cd17374  255 mqtlrtvlavlgkgssaaaftisyvytaelfptvlrqtgmglnsmfariggilaplimllGVYSPLLPMIIYGVLPILAG 334


                 ....*..
gi 569007195 448 FTVFLLP 454
Cdd:cd17374  335 LLALLLP 341
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 11-449 9.55e-89

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 280.36  E-value: 9.55e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195   11 GSLGRFQILQIVFLFLLNAIVVPHIGMENFTAAIPNHRCWVPildnDTASdngsriLSQDDLLRISIPLDSNLRLDKCRR 90
Cdd:TIGR00898   1 GEFGPFQRRTFLLLALPIALLAFHFVLIVFLGATPEHHCRLP----DAAN------LSSRCELNLTLPRLPDGRPESCLR 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195   91 FAQPQWHLLHLNGTFSNVS----EPDTEPCVDGWVYDRSNFLSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHL 166
Cdd:TIGR00898  71 FMVDQWANPSLLGCEPLKLsdlgLAATEPCLDGWEYSYDTFSSTIVTEWDLVCEDAWKVDLTQSCFFVGVLLGSFVFGYL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195  167 SDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFM 246
Cdd:TIGR00898 151 SDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLV 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195  247 ILAGLAFLFRIWHHLQLTMSAPIFFFLILTRWLSESARWLILINKPQKGLKELRKVAHMNGMKnsgdLTMEIVRTSMKAE 326
Cdd:TIGR00898 231 LLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKK----LPAEVLSLSLEKD 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195  327 LEAAKTKPSLRDLFHTSILRKRICVLSFIRLFFTVSIIGLAVHLQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRI 406
Cdd:TIGR00898 307 LSSSKKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRY 386

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 569007195  407 TYLVLMSLRGIFIMIAVFVPQATYYANLPWIFYGGFSIFNAFT 449
Cdd:TIGR00898 387 TMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQ 429
Sugar_tr pfam00083
Sugar (and other) transporter;
151-426 5.95e-14

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 73.85  E-value: 5.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195  151 SFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAP---SFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSP 227
Cdd:pfam00083  54 IFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPK 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195  228 KFLAMMAVLSSCAPNIGFMILAGLAFLFRI------WHHLQ-LTMSAPIFFFLILTrWLSESARWLILINKPQKGLKELR 300
Cdd:pfam00083 134 KLRGALGSLYQLAITFGILLAYIFGLGLNKtsnsdgWRIPLgLQLVPALLLIIGLL-FLPESPRWLVEKGRLEEAREVLA 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195  301 KVahmngmKNSGDLTMEIV--RTSMKAELEAAKTKPSLRDLFHTSILRKRICVLSFIRLFFT--VSIIGLAVHLQHLS-- 374
Cdd:pfam00083 213 KL------RGVPDVDRELDeiKDSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTgiNAIFYYSTTIFENLgl 286

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 569007195  375 SNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVlmslrGIFIMIAVFVP 426
Cdd:pfam00083 287 SDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLL-----GAAGMAICFVI 333
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
127-454 1.96e-13

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 71.54  E-value: 1.96e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 127 FLSTIVTEWDLvceSQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLA 206
Cdd:COG2814   32 ALPLIAADLGA---SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQ 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 207 GMSVEPISVNSHLLMLEWTSP----KFLAMMAVLSSCAPNIGfMILAGLAFLFRIWHHLQLTMSAPIFFFLILTRWLses 282
Cdd:COG2814  109 GLGAGALFPAALALIADLVPPerrgRALGLLGAGLGLGPALG-PLLGGLLADLFGWRWVFLVNAVLALLALLLLLRL--- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 283 arwlilinkpqkgLKELRKVahmngmknsgdltmeivrtsmkaelEAAKTKPSLRDLFHTSILRKRICVLSFIRLFFTVS 362
Cdd:COG2814  185 -------------LPESRPA-------------------------ARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFAL 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 363 IIGLAVHLQ---HLSSNIILLQFLISALA-ILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQatyyanlPWIF 438
Cdd:COG2814  227 FTYLPLYLQevlGLSASAAGLLLALFGLGgVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS-------LWLL 299

                        330
                 ....*....|....*.
gi 569007195 439 YGGFSIFNAFTVFLLP 454
Cdd:COG2814  300 LLALFLLGFGFGLLFP 315
xylE PRK10077
D-xylose transporter XylE; Provisional
 143-437 1.74e-07

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 53.54  E-value: 1.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 143 ALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCA---------------LLQFAITETCVAFAPSFFIYcslRFLAG 207
Cdd:PRK10077  55 SLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAavlffisalgsawpeFGFTSIGPDNTGYVPEFVIY---RIIGG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 208 MSVEPISvnshllMLewtSPKFLAMMA------VLSSCAPnigFMILAGLAFLFRI-----------------WHHLQLT 264
Cdd:PRK10077 132 IGVGLAS------ML---SPMYIAEIApahirgKLVSFNQ---FAIIFGQLVVYFVnyfiarsgdaswlntdgWRYMFAS 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 265 MSAPIFFFLILTRWLSESARWLILINKPQKGLKELRKVahmNGMKNSGDLTMEIVRTSmkaELEAAKTKPslrdLFHTSI 344
Cdd:PRK10077 200 EAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKI---MGNTLATQALQEIKHSL---DHGRKTGGK----LLMFGV 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 345 LrkriCVLSFIRLFFTVSIIGLAVHLQH---------LSSNIILLQFLI-SALAILVSVIGPFVLNHIGRRitylVLMSL 414
Cdd:PRK10077 270 G----VIVIGVMLSVFQQFVGINVVLYYapeifktlgASTDIALLQTIIvGVINLTFTVLAIMTVDKFGRK----PLQII 341

                        330       340
                 ....*....|....*....|...
gi 569007195 415 RGIFIMIAVFVPQATYYANLPWI 437
Cdd:PRK10077 342 GALGMAIGMFSLGTAFYTQAPGI 364
 
Name Accession Description Interval E-value
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 109-454 5.68e-114

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 339.65  E-value: 5.68e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 109 SEPDTEPCVDGWVYDRSNFLSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITET 188
Cdd:cd17374    1 SEADTEPCVDGWVYDRSKFTSTIVTEWDLVCESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 189 CVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAP 268
Cdd:cd17374   81 CAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITLTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 269 IFFFLILTRWLSesarwlilinkpqkglkelrkvahmngmknsgdltmeivrtsmkaeleaaktkpslrdlfhtsilrKR 348
Cdd:cd17374  161 FFLFFLYSWWLP------------------------------------------------------------------KR 174

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 349 ICVLSFIRLFFTVSIIGLAVHLQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQ- 427
Cdd:cd17374  175 TLILSFVWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVPQe 254

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 428 ------------------------------------------------------------ATYYANLPWIFYGGFSIFNA 447
Cdd:cd17374  255 mqtlrtvlavlgkgssaaaftisyvytaelfptvlrqtgmglnsmfariggilaplimllGVYSPLLPMIIYGVLPILAG 334


                 ....*..
gi 569007195 448 FTVFLLP 454
Cdd:cd17374  335 LLALLLP 341
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 11-449 9.55e-89

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 280.36  E-value: 9.55e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195   11 GSLGRFQILQIVFLFLLNAIVVPHIGMENFTAAIPNHRCWVPildnDTASdngsriLSQDDLLRISIPLDSNLRLDKCRR 90
Cdd:TIGR00898   1 GEFGPFQRRTFLLLALPIALLAFHFVLIVFLGATPEHHCRLP----DAAN------LSSRCELNLTLPRLPDGRPESCLR 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195   91 FAQPQWHLLHLNGTFSNVS----EPDTEPCVDGWVYDRSNFLSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHL 166
Cdd:TIGR00898  71 FMVDQWANPSLLGCEPLKLsdlgLAATEPCLDGWEYSYDTFSSTIVTEWDLVCEDAWKVDLTQSCFFVGVLLGSFVFGYL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195  167 SDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFM 246
Cdd:TIGR00898 151 SDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSLGLV 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195  247 ILAGLAFLFRIWHHLQLTMSAPIFFFLILTRWLSESARWLILINKPQKGLKELRKVAHMNGMKnsgdLTMEIVRTSMKAE 326
Cdd:TIGR00898 231 LLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGKK----LPAEVLSLSLEKD 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195  327 LEAAKTKPSLRDLFHTSILRKRICVLSFIRLFFTVSIIGLAVHLQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRI 406
Cdd:TIGR00898 307 LSSSKKQYSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRY 386

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 569007195  407 TYLVLMSLRGIFIMIAVFVPQATYYANLPWIFYGGFSIFNAFT 449
Cdd:TIGR00898 387 TMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQ 429
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 113-427 5.85e-57

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 192.63  E-value: 5.85e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 113 TEPCVDGWVYDRSNFLSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAF 192
Cdd:cd17446    3 TEPCTDGWVYDKSEFPSTIITEWDLVCNHRALRQLAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 193 APSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAPIFFF 272
Cdd:cd17446   83 SPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRVRAVVGTLLGYCYTLGQLILAGVAYAIRDWRWLQLAVSLPFFIF 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 273 LILTRWLsesarwlilinkpqkglkelrkvAHMNgmknsgdltmeivrtsmkaeleaaktkpslrdlfhtsilrkriCVL 352
Cdd:cd17446  163 FLYSWWF-----------------------PRIT-------------------------------------------FCL 176

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569007195 353 SFIRLFFTVSIIGLAVHLQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQ 427
Cdd:cd17446  177 SLVWFSTSFAYYGLAMDLQKFGVSIYLIQIIFGAVDIPAKFISTLTMSYLGRRPTQAAALILAGIMILANIFVPQ 251
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 119-450 2.67e-43

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 155.82  E-value: 2.67e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 119 GWVYDRSNFLSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFI 198
Cdd:cd17317    1 GWEFDYSVSESTIVTEWDLVCDRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYEL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 199 YCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAPIFFFLILTRW 278
Cdd:cd17317   81 FLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWW 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 279 LSesarwlilinkpqkglkelrkvahmngmknsgdltmeivrtsmkaeleaaktkpslrdlfhtsilrKRICVLSFIRLF 358
Cdd:cd17317  161 LP------------------------------------------------------------------RRTIIVGLIWFV 174

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 359 FTVSIIGLAVHLQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQATYYANLPWIF 438
Cdd:cd17317  175 TSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTLAL 254

                        330
                 ....*....|..
gi 569007195 439 YGGFSIFNAFTV 450
Cdd:cd17317  255 VGKFAISAAFSV 266
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 109-279 6.71e-40

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 147.18  E-value: 6.71e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 109 SEPDTEPCVDGWVYDRSNFLSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITET 188
Cdd:cd17447    1 SDLPVVPCQNGWVYDHSTFSSTIATEWDLVCDRKGLNQATATFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 189 CVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAP 268
Cdd:cd17447   81 ASAFSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHRTVAGVLISLFWTVGNMLLALVAYLIRDWRWLILAVTLP 160

                        170
                 ....*....|.
gi 569007195 269 IFFFLILTRWL 279
Cdd:cd17447  161 CAPGIITWWWV 171
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 109-274 3.79e-28

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 114.37  E-value: 3.79e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 109 SEPDTEPCVDGWVYDRSNflSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITET 188
Cdd:cd17379    1 SMLPLSPCQDGWVYNTPR--SSIVTEFNLVCEDAWKLDLFQSSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 189 CVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAP 268
Cdd:cd17379   79 LMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTVGIVYQMFFTLGLLILPGIAYFIPHWRWLQLAVTLP 158


                 ....*.
gi 569007195 269 IFFFLI 274
Cdd:cd17379  159 NFLFLL 164
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 109-450 3.55e-26

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 109.09  E-value: 3.55e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 109 SEPDTEPCVDGWVYDRSNFLSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITET 188
Cdd:cd17376    1 TQIEQEPCLDGWEYSQDVYLSTIVTEWNLVCEDDWKVPLTTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 189 CVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCA-PNIGFMILAGLAFLFRIWHHLQLTMSA 267
Cdd:cd17376   81 LQIFSPSWEMFTVLFVIVGMGQISNYVVAFVLGTEILGKSVRILFSTLGVCIfYAIGYMLLPLFAYFIRDWRMLLLALTL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 268 PIFFFLILtrWlsesarWLILInkpqkglkelrkvahmngmknsgdltmeivrtsmkaeleaaktkpslrdlfhTSIlrk 347
Cdd:cd17376  161 PGVLCVPL--W------WFIPI----------------------------------------------------TTI--- 177

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 348 rICVLsfIRLFFTVSIIGLAVHLQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQ 427
Cdd:cd17376  178 -MSLL--LWMAISVGYFGLSLNTPNLHGDPYLNCFLSAVIEVPAYIIAWLLLRSLPRRYSIAATLVLGGGVLLFIQLVPT 254

                        330       340
                 ....*....|....*....|...
gi 569007195 428 ATYYANLPWIFYGGFSIFNAFTV 450
Cdd:cd17376  255 DLQVLATALVMLGKFGITAAFSM 277
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 115-266 1.30e-19

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 89.81  E-value: 1.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 115 PCVDGWVYDRSNFLSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAP 194
Cdd:cd17375    7 SCSDGFVYDQSKWESSIVTDWDLVCDREWLAKLIQPIFMLGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTF 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569007195 195 SFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMS 266
Cdd:cd17375   87 DYYSFVIVRFLLAMVSSGYLVVVFVYVTEFTGIKARTWASMHVHAFFAVGIMVVALVGYLVRTWWIYQIILS 158
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 109-288 8.75e-19

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 87.52  E-value: 8.75e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 109 SEPDTEPCVDGWVYDRSNFL-STIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITE 187
Cdd:cd17443    1 PSNLAVLCTGGWPFSAAAGLgSNLVTEWNLVCDDGWKVPLEKISYLLGWLLGYIILGAGCDRLGRRAAFVLSLVLATLLG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 188 TCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSA 267
Cdd:cd17443   81 VSVALSASPPTFLVLRLLQGGTLAGVFLSLYIARLELCDPSHRLMVSMGAGFFSVAGELLLPGLAVLCRDWRVLQGVGTL 160

                        170       180
                 ....*....|....*....|.
gi 569007195 268 PIffFLILTRWLSESARWLIL 288
Cdd:cd17443  161 PL--LLLLLYWCFPSRNGLIL 179
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 109-273 2.00e-18

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 86.37  E-value: 2.00e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 109 SEPDTEPCVDGWVYDRSNFLST-IVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITE 187
Cdd:cd17445    1 TQTGVRHCDAGWNYTGLPGLTNnIVTEWDLVCSRYWLVPLEQVCFILGFASGYLCLGYTADRLGRRRTLLLSLTLAVPFG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 188 TCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSA 267
Cdd:cd17445   81 VLVAVAASPSLFMAMRFLLGAALAGVYLTLYLTRLELCDPPQRLLVAMAGGLTMVGGHFLLLGLALGCGSWRVLQGTITA 160


                 ....*.
gi 569007195 268 PIFFFL 273
Cdd:cd17445  161 PLSLFL 166
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 129-428 1.31e-16

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 80.87  E-value: 1.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 129 STIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSD-RFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAG 207
Cdd:cd17378   19 VSIVSEWGLICAGSFLVGLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTG 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 208 MSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFL-FRIWHHLQLTMSAPIFFFLILtrwlsesarWL 286
Cdd:cd17378   99 FGRSGIGTCALVLATEPVGPKWRGQVGMSTFFFFVLGFMSLPGIAYLnGSSWRVLYFWTSIPALIYCIL---------VY 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 287 ILInkpqkglkelrkvahmngmknsgdltmeivrtsmkaeleaaktkpslrdlfhtsilrKRICVLSFIRLFFTVSIIGL 366
Cdd:cd17378  170 LFA---------------------------------------------------------RRLLAVMVIGFGIGMVYYGI 192

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569007195 367 AVHLQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQA 428
Cdd:cd17378  193 PLAVGNLKFNIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFVLSIG 254
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 151-448 2.36e-16

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 81.15  E-value: 2.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 151 SFMIGLFIGGIICGHLSDRFGRKFILT-CALLQF--AITETCVAFAPSFFIYCSLRFLAGMSVePISVNSHLLMLEWTSP 227
Cdd:cd17357   57 IFFIGGAIGSFISAFLANRFGRKNGLLiSNALLVvsSLLMFLSKSAKSPELLIFGRFLVGIAC-GLSTGFVPMYLQEISP 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 228 KFL-AMMAVLSSCAPNIGFMI--LAGLAFLF---RIWHHLQLTMSAPIFFFLILTRWLSESARWLIL----INKPQKGLK 297
Cdd:cd17357  136 SELrGALGSLTQIGVTLGILLgqVFGLPSVLgteTLWPYLLFFPGIPALLQLAALPFFPESPKFLLIskgdEEEAEKSLK 215

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 298 ELRKVahmngmknSGDLTMEIVRTSMKAELEAAKTKPSLRDLFHTSILRKR---ICVLSFIRLF--------FTVSIIGL 366
Cdd:cd17357  216 FLRGI--------EDDVDQELEEIKKESEQMGDQKQVSLMQLLRDPSLRLPlllVLVVSASQQFsginaiffYSTFIFEN 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 367 AVHLQHLSsniILLQFLISALAILVSVIGPFVLNHIGRR---ITYLVLMSLRGIFIMIAVFVpqATYYANLPWIFYGGFS 443
Cdd:cd17357  288 AGFSPQLA---EWANLGIGIVNVLSTIVGPFLIEKVGRRpllLISLSVCAVALLLMSVFLFL--SEQNSWMSYGCIVAIF 362


                 ....*
gi 569007195 444 IFNAF 448
Cdd:cd17357  363 LFIFF 367
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 128-424 3.76e-15

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 77.01  E-value: 3.76e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195  128 LSTIVTEWDLvcESQALNSVtkFSF-MIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLA 206
Cdd:TIGR00895  40 APAISAEWGL--DPVQLGFL--FSAgLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLA 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195  207 GMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGfMILAGLAFLFRI----WHHLQLTMS-APIFFFLILTRWLSE 281
Cdd:TIGR00895 116 GLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIG-AAVGGFLAGWLIpvfgWRSLFYVGGiAPLLLLLLLMRFLPE 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195  282 SARWLILiNKPQKGLKELRKVAHMNGMKNSGDLTMEIVRTSMKAELEAAKTKPSLrdLFHTSILRKRICVLSFIRLFFTV 361
Cdd:TIGR00895 195 SIDFLVS-KRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGKT--ARITVLLWLLYFMLLVGVYFLTN 271

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569007195  362 SIIGLAVHLQHLSSNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMsLRGIFIMIAVF 424
Cdd:TIGR00895 272 WLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLL-LGAVFAVLVGS 333
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 124-278 9.12e-15

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 75.66  E-value: 9.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 124 RSNFLSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLR 203
Cdd:cd17444   17 RAGLVQNIVSKWDLVCDSSWKVHIAKFSLLVGLIFGYLITGCLADWFGRRPVLLFSVVFILIFGLTVALSVNVTMFSTLR 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569007195 204 FLAGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAPifFFLILTRW 278
Cdd:cd17444   97 FFEGFCLAGIILSLYALRIELCPPGHRFMITMVASFIAMAGQFLMPGLAALCRDWQVLQAVIICP--FLLMLSYW 169
Sugar_tr pfam00083
Sugar (and other) transporter;
151-426 5.95e-14

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 73.85  E-value: 5.95e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195  151 SFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAP---SFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSP 227
Cdd:pfam00083  54 IFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPK 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195  228 KFLAMMAVLSSCAPNIGFMILAGLAFLFRI------WHHLQ-LTMSAPIFFFLILTrWLSESARWLILINKPQKGLKELR 300
Cdd:pfam00083 134 KLRGALGSLYQLAITFGILLAYIFGLGLNKtsnsdgWRIPLgLQLVPALLLIIGLL-FLPESPRWLVEKGRLEEAREVLA 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195  301 KVahmngmKNSGDLTMEIV--RTSMKAELEAAKTKPSLRDLFHTSILRKRICVLSFIRLFFT--VSIIGLAVHLQHLS-- 374
Cdd:pfam00083 213 KL------RGVPDVDRELDeiKDSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTgiNAIFYYSTTIFENLgl 286

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 569007195  375 SNIILLQFLISALAILVSVIGPFVLNHIGRRITYLVlmslrGIFIMIAVFVP 426
Cdd:pfam00083 287 SDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLL-----GAAGMAICFVI 333
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
127-454 1.96e-13

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 71.54  E-value: 1.96e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 127 FLSTIVTEWDLvceSQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLA 206
Cdd:COG2814   32 ALPLIAADLGA---SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQ 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 207 GMSVEPISVNSHLLMLEWTSP----KFLAMMAVLSSCAPNIGfMILAGLAFLFRIWHHLQLTMSAPIFFFLILTRWLses 282
Cdd:COG2814  109 GLGAGALFPAALALIADLVPPerrgRALGLLGAGLGLGPALG-PLLGGLLADLFGWRWVFLVNAVLALLALLLLLRL--- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 283 arwlilinkpqkgLKELRKVahmngmknsgdltmeivrtsmkaelEAAKTKPSLRDLFHTSILRKRICVLSFIRLFFTVS 362
Cdd:COG2814  185 -------------LPESRPA-------------------------ARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFAL 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 363 IIGLAVHLQ---HLSSNIILLQFLISALA-ILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQatyyanlPWIF 438
Cdd:COG2814  227 FTYLPLYLQevlGLSASAAGLLLALFGLGgVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGS-------LWLL 299

                        330
                 ....*....|....*.
gi 569007195 439 YGGFSIFNAFTVFLLP 454
Cdd:COG2814  300 LLALFLLGFGFGLLFP 315
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 120-274 6.61e-13

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 69.85  E-value: 6.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 120 WVYD-RSNFLSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFI 198
Cdd:cd17373    1 WDYGiRAGLVQNAVSKWDLVCDNGWKVHLEQFSLLLGLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTM 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569007195 199 YCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAPIFFFLI 274
Cdd:cd17373   81 FSTLRFLEGFCLAGIILTLYLLRLELCDPGKRLMITMVASLVAVAGQFLMPGLAALCRDWRVLQALIICPFLLMLL 156
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 121-276 1.70e-12

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 68.65  E-value: 1.70e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 121 VYDRSNFLStIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYC 200
Cdd:cd17377   18 VHFSSSFTS-IVSEWFLVGNAAYKVSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFA 96

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569007195 201 SLRFLAGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAPIFFFLILT 276
Cdd:cd17377   97 VSRFLVGVMNGGMSLVAFVLLNECVGKSYWALAGSLGGLFFAVGIAQYALLGYFIRSWRTLAVVVNLQGTLVFLLS 172
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 116-279 2.01e-12

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 68.40  E-value: 2.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 116 CVDGWVYDRSNFLSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPS 195
Cdd:cd17316    9 FFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 196 FFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRI-------WHHLQLTMSAP 268
Cdd:cd17316   89 PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPllsgdwgWRILFLIGALP 168

                        170
                 ....*....|.
gi 569007195 269 IFFFLILTRWL 279
Cdd:cd17316  169 ALLALLLRRRT 179
MFS_1 pfam07690
Major Facilitator Superfamily;
152-450 3.59e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 67.44  E-value: 3.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195  152 FMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLA 231
Cdd:pfam07690  41 FSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERG 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195  232 MMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAPIFFFLILTrwlsesARWLILINKPQKGLKELRKVAHMNGMKns 311
Cdd:pfam07690 121 RALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAA------VLLLLPRPPPESKRPKPAEEARLSLIV-- 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195  312 gdltmeivrtsmkaeleaaktkpSLRDLFHTSILRKRICVLSFIRLFFTVSI-IGLAVHLQHLSSNIILLQF-LISALAI 389
Cdd:pfam07690 193 -----------------------AWKALLRDPVLWLLLALLLFGFAFFGLLTyLPLYQEVLGLSALLAGLLLgLGGLLGA 249

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569007195  390 LVSVIGPFVLNHIGRRITYLVLMSLrGIFIMIAVFVPQATYYANLPWIFYGGFSIFNAFTV 450
Cdd:pfam07690 250 IGRLLLGRLSDRLGRRRRLLLALLL-LILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVF 309
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
151-279 3.65e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 67.59  E-value: 3.65e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 151 SFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFL 230
Cdd:COG2271   53 AFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKER 132

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 569007195 231 AMMAVLSSCAPNIGFMI---LAGLAFLFRIWHHLQLTMSAPIFFFLILTRWL 279
Cdd:COG2271  133 GRALGIFNAGGPLGGALappLLGWLLAAFGWRAAFLILGLPGLLLALLRFWL 184
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 154-444 1.28e-11

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 66.44  E-value: 1.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 154 IGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPS-FFIYCSlRFLAGMSVEPISVNSHLLMLEWTSPKFLAM 232
Cdd:cd17358   52 LGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDvWMLYLG-RFLAGFGGGAASVVVPVYIAEIAPKNVRGA 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 233 MAVLSSCAPNIGFMILAGLAFLFRiWHHLQLTMSAPIFFFLILTRWLSESARWLILINKPQKGLKELRKvahMNGmKNSG 312
Cdd:cd17358  131 LGSLNQLLVNIGILLGYVLGSFLP-WRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQF---LRG-KDAD 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 313 DLTMEIVRTSMKAELEAAKTKPSLRDLFHTSILRK-RICVL---------SFIRLFFTVSIIGLAVHLqhLSSNIILLqf 382
Cdd:cd17358  206 ISKEAAEIQEELAELEKEAKESSFSDLFQRKYLKPlVIGLGlmlfqqlsgINAVIFYASSIFDEAGSG--LDPNTATI-- 281

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569007195 383 LISALAILVSVIGPFVLNHIGRRITYLV-------LMSLRGIFIMIAVFVPQATYYANLPW----IFYGGFSI 444
Cdd:cd17358  282 IIGVVQVVGTLVATLLVDRLGRRPLLLVsaigmgiGLLALGLYFYLQEHGALLSSVSWLPLvglvIYIISFSI 354
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 153-255 3.56e-10

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 61.45  E-value: 3.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 153 MIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAM 232
Cdd:cd17365   44 LFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSL 123

                         90       100
                 ....*....|....*....|...
gi 569007195 233 MAVLSSCAPNIGFMILAGLAFLF 255
Cdd:cd17365  124 AVTLMFCGYPLGAALGGFLAAAL 146
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 151-289 4.07e-10

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 60.60  E-value: 4.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 151 SFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFL 230
Cdd:COG0477   57 AYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARER 136

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569007195 231 AMMAVLSSCAPNIGFMI--LAGLAFLFRIWHHLQLTMSAPIFFFLILTRWLSESARWLILI 289
Cdd:COG0477  137 GRALGLWGAAIGLGLALgpLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLA 197
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 151-452 6.61e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 60.90  E-value: 6.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 151 SFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFL 230
Cdd:cd06174   39 LFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERER 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 231 AMMAVLSSCAPNIGF---MILAGLAFLFRI--WHHLQLTMSAPIFFFLILTRWLSESARWLILINkpqkglkelrkvahm 305
Cdd:cd06174  119 GRALGLLQAFGSVGGilgPLLGGILASSLGfgWRAVFLIAAALALLAAILLLLVVPDPPESARAK--------------- 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 306 ngmknsgdltmeivrtsmKAELEAAKTKPSLRDLFHTSILRKrICVLSFIRLFFTVSIIG-----LAVHLQHLSSNIILL 380
Cdd:cd06174  184 ------------------NEEASSKSVLKLLKRVLKNPGLWL-LLLAIFLVNLAYYSFSTllplfLLDLGGLSVAVAGLL 244

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569007195 381 QFLISALAILVSVIGPFVLN-HIGRRITYLVLMSLRGIFIMIAVFVPQATYYANLPWIFYGGFSIFNAFTVFL 452
Cdd:cd06174  245 LSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFAL 317
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
152-449 1.59e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 59.51  E-value: 1.59e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 152 FMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLA 231
Cdd:COG2223   49 PVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRG 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 232 MMAVLSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAPIFFFLILTrwlsesarwlilinkpqkglkelrkVAHMNGMKNS 311
Cdd:COG2223  129 LALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVA-------------------------VLAWLFLRDP 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 312 GDLTMEIVRTSMKAELEAAKTkpslrdlfhtsilrKRICVLSFIRLFFTVSIIGLAVHLQHLSSNII--------LLQFL 383
Cdd:COG2223  184 PAGAAAAAKASLRDQLEALRD--------------PRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFglsaatagLLAAL 249

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569007195 384 ISALAILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQAtyyanlPWIFYGGFSIFNAFT 449
Cdd:COG2223  250 FALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGS------LWLFLVLFLLLGLAL 309
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 151-292 1.83e-09

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 59.50  E-value: 1.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 151 SFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVnshllmlewTSPKFL 230
Cdd:cd17359   44 SALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASA---------LVPMYI 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 231 AMMAV------LSSCAPnigFMILAG--LAFLFR---------------IWHHLQLTMSAPIFFFLILTRWLSESARWLI 287
Cdd:cd17359  115 AEVAPaeirgrLVSLNQ---LMIVFGqlLAYIVNylianaggadwlgaeGWRWMLGLEAIPAILFLLGMLFIPESPRWLV 191


                 ....*
gi 569007195 288 LINKP 292
Cdd:cd17359  192 SKGKP 196
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 119-455 2.03e-09

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 59.24  E-value: 2.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 119 GWVYDRSNF------LSTIVTEWDLVCESQA-LNSVTkfsfMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVA 191
Cdd:cd17371    7 GWALDGFDLlllglvLPALIAEFGLDEAEAGlLGTVT----LAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 192 FAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFL-FRI------WHHLQLT 264
Cdd:cd17371   83 FAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALlFPLlppeiaWRVLFLL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 265 MSAPIFFFLILTRWLSESARWLIlinkpqkglkelrkvahmngmknsgdltmeivrtsMKAELEAAKTKPSLRDLFHTSI 344
Cdd:cd17371  163 GALPALLVLFIRRFVKEPPQWQA-----------------------------------ARAARRHFADRPSLRELFSPPL 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 345 LRKRIcvlsFIRLFFTVSIIGlavhlqHLSSNIILLQFL-------------ISALAILVSVIGPFVL----NHIGRRIT 407
Cdd:cd17371  208 LRTTL----LASLLATGALGG------YYGITTWLPSYLtgerglsfegsagYLVVTILGGFLGYLAGgflaDRIGRRNN 277

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 569007195 408 YLVLMSLRGIFIMIAVFVPqATYYANLPWIFYGGFSIFNAFTVF--LLPE 455
Cdd:cd17371  278 FALFALGSAISILLYFFLP-LSPTLILILGFPLGFFASGPFSGMgaYLTE 326
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 151-290 8.51e-08

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 54.12  E-value: 8.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 151 SFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVnSHLLMLEWTSPKFL 230
Cdd:cd17330   42 SYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSV-AQAYIADITDEEER 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569007195 231 AM-MAVLSSCApNIGFMILAGLAFLFRIWHHLQLTMSAPIFFF---LILTRWLSESARWLILIN 290
Cdd:cd17330  121 AKaFGIISAAF-GLGFILGPALGGFLSTPYGYALPFLVAAALAllnLVLVLFFLPPLRRLLLVY 183
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 134-289 1.04e-07

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 54.05  E-value: 1.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 134 EWDLVCESQALnsVTKFSFmIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVE-- 211
Cdd:cd17441   28 EWRLPSWQVAL--LTSVVF-IGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGgv 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 212 PISVNshlLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLFRI---WHHLQLTMSAPIFFFLILTRWLSESARWLIL 288
Cdd:cd17441  105 PQSVT---LYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPtlgWRWLLILSALPLLIFAVLCFWLPESARYWTT 181


                 .
gi 569007195 289 I 289
Cdd:cd17441  182 I 182
2_A_01_02 TIGR00880
Multidrug resistance protein;
151-282 1.43e-07

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 50.73  E-value: 1.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195  151 SFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLML----EWTS 226
Cdd:TIGR00880   6 GYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIAdiypPEER 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569007195  227 PKFLAMMAVLSSCAPNIGFMiLAGLAFLFRIWHHLQLTMSA-PIFFFLILTRWLSES 282
Cdd:TIGR00880  86 GVALGLMSAGIALGPLLGPP-LGGVLAQFLGWRAPFLFLAIlALAAFILLAFLLPET 141
xylE PRK10077
D-xylose transporter XylE; Provisional
 143-437 1.74e-07

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 53.54  E-value: 1.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 143 ALNSVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCA---------------LLQFAITETCVAFAPSFFIYcslRFLAG 207
Cdd:PRK10077  55 SLLGFCVASALIGCIIGGALGGYCSNRFGRRDSLKIAavlffisalgsawpeFGFTSIGPDNTGYVPEFVIY---RIIGG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 208 MSVEPISvnshllMLewtSPKFLAMMA------VLSSCAPnigFMILAGLAFLFRI-----------------WHHLQLT 264
Cdd:PRK10077 132 IGVGLAS------ML---SPMYIAEIApahirgKLVSFNQ---FAIIFGQLVVYFVnyfiarsgdaswlntdgWRYMFAS 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 265 MSAPIFFFLILTRWLSESARWLILINKPQKGLKELRKVahmNGMKNSGDLTMEIVRTSmkaELEAAKTKPslrdLFHTSI 344
Cdd:PRK10077 200 EAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKI---MGNTLATQALQEIKHSL---DHGRKTGGK----LLMFGV 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 345 LrkriCVLSFIRLFFTVSIIGLAVHLQH---------LSSNIILLQFLI-SALAILVSVIGPFVLNHIGRRitylVLMSL 414
Cdd:PRK10077 270 G----VIVIGVMLSVFQQFVGINVVLYYapeifktlgASTDIALLQTIIvGVINLTFTVLAIMTVDKFGRK----PLQII 341

                        330       340
                 ....*....|....*....|...
gi 569007195 415 RGIFIMIAVFVPQATYYANLPWI 437
Cdd:PRK10077 342 GALGMAIGMFSLGTAFYTQAPGI 364
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 134-280 6.86e-07

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 51.38  E-value: 6.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 134 EWDLVCESQALnsVTKFSFmIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPI 213
Cdd:cd17372   28 EWNLSAWQVAL--ITSVVF-AGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGGG 104

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 214 SVnSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFLF--RI-WHHLQLTMSAPIFFFLILTRWLS 280
Cdd:cd17372  105 PQ-LASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVmpRLgWRWLLAFSSVPSSLLLVFYRWTP 173
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 154-279 1.87e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 49.92  E-value: 1.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 154 IGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFL--- 230
Cdd:cd06173  255 VGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRgrv 334

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 569007195 231 -AMMAVLSSCAPNIGfMILAGLAFLFRIWHHLQLTMSAPIFFFLILTRWL 279
Cdd:cd06173  335 fSVYNALNSGAMPLG-ALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 152-209 4.50e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 48.70  E-value: 4.50e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 569007195 152 FMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMS 209
Cdd:cd17324   43 YALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLA 100
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
150-447 9.02e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 47.93  E-value: 9.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 150 FSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFL--AGMSVEPISVNSHLLMLEwtsP 227
Cdd:COG0738   50 FAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLlgLGLGLLDVAANPYVAALG---P 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 228 KFLAMMAVLSSCAPNIGFMILAGLAFLFrIWHHLQLTMSAPIFFFLIltrwlsesarwLILInkpqkglkelrkvahmng 307
Cdd:COG0738  127 ETAASRLNLLHAFFSLGALLGPLLGGLL-ILLGLSLSWHLPYLILAV-----------LLLL------------------ 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 308 mknsgdLTMEIVRTSMKaELEAAKTKPSLRDLFHTSILRKRICVLSFIRLFFTVS--------IIGLAVHLQHLSSNIIL 379
Cdd:COG0738  177 ------LALLFLRSKLP-EIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGaegaigdwLPLYLKDVLGLSEATAA 249

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569007195 380 LQFLISALAILVS-VIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQATyyanLPWIFYGGFSIFNA 447
Cdd:COG0738  250 LGLSLFWGGMTIGrFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPW----LALIGLALVGLGLS 314
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 151-277 1.07e-05

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 47.76  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195  151 SFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLE-WTSPKF 229
Cdd:TIGR00710  48 LYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDiYPGEEL 127

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 569007195  230 LAMMAVLSSC---APNIGFMIlAGLAFLFRIWHHL-------QLTMSAPIFFFLILTR 277
Cdd:TIGR00710 128 SRIYSILMPVlalAPAVAPLL-GGYILVWLSWHAIfaflslaGILLSALIFFILPETL 184
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 151-447 1.35e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 47.19  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 151 SFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFL 230
Cdd:cd17325   39 AYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEER 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 231 A-MMAVLSScAPNIGFMI---LAGLAFLFRIWHHLQLTMSAPIFFFLILTRWLsesarwlilinkpqkglkelrkvahmn 306
Cdd:cd17325  119 GrAMGIFSS-AIGLGFLIgplLGGLLADALGYRAPFLVCAALALLALVLALLL--------------------------- 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 307 gmknsgdltmeiVRTSMKAELEAAKTKPSLRDLFHTSILRKRICVLSFIRLFFTVSIIGL-------AVHLQHLSSNIIL 379
Cdd:cd17325  171 ------------LPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALepflplyAAELGGLSPAQIG 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569007195 380 LQFLISALA-ILVSVIGPFVLNHIGRRITYLVLMSLRGIFIMIAVFVPQATYYANLPWIFYGGFSIFNA 447
Cdd:cd17325  239 LLFGAQGLAsALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFP 307
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 151-269 1.63e-05

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 46.99  E-value: 1.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195  151 SFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFL 230
Cdd:TIGR00881  38 SFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSER 117

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 569007195  231 AMMAVLSSCAPNIGFMILAGLAFLFRIWH---HLQLTMSAPI 269
Cdd:TIGR00881 118 GTWVSFWNCSHNVGGGLLPPLVLFGIAELyswHWVFIVPGII 159
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 155-285 2.31e-05

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 46.49  E-value: 2.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 155 GLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLAMMA 234
Cdd:cd17360   47 GAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLV 126

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 569007195 235 VLSSCAPNIGFMILAGLAFLFRIWHH-----LQLTMSAPIFFFLILTrWLSESARW 285
Cdd:cd17360  127 TINVLFITGGQFVAYVINGAFSYLPGgwrwmLGLAAVPAVLQFIGLL-FLPESPRW 181
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 150-207 6.01e-05

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 45.30  E-value: 6.01e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 569007195 150 FSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAG 207
Cdd:cd17328   41 TVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVG 98
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 146-452 6.08e-05

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 45.30  E-value: 6.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 146 SVTKFSFMIGLFIGGIICGHLSDRFGRK--------FILTCALLqFAITETcvafAPSFFIYCSLRFLAGMSVEpISVNS 217
Cdd:cd17432   53 SLTVSIFPLGGLFGSLLVGPLVIRLGRKgtlllnniFAIVAAIL-MGLSKI----AKSFEMIIVGRFLVGINAG-ISLNV 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 218 HLLMLEWTSPKFL-AMMAVLSSCAPNIGFMI--LAGLAFLF---RIWHHLQLTMSAPIFFFLILTRWLSESARWLiLINK 291
Cdd:cd17432  127 VPMYLGESAPKNLrGAVGLVPAIFITLGILLgqVLGLRELLgneEGWPLLLALTGVPALLQLLTLPFFPESPRYL-LIEK 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 292 -----PQKGLKELRkvahmngmkNSGDLTMEIvrTSMKAELEAAKTKP--SLRDLFHTSILRKRicVLSFIRLFFTVSII 364
Cdd:cd17432  206 gdeeaARKALQRLR---------GKEDVDDEM--EEMLEEQRAEKGVGtvSVLELFRDRSVRWQ--LISIIVLMAGQQLC 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 365 GL-AVHLqhLSSNIIL--------LQFL---ISALAILVSVIGPFVLNHIGRRitylvLMSLRGIFIMI---AVFVPQAT 429
Cdd:cd17432  273 GInAIYF--YADSIFLeagipedkIQYVtvgTGACEVLATITCVLVIERLGRR-----PLLIGGFGLMAvwcAVLTVALS 345

                        330       340
                 ....*....|....*....|...
gi 569007195 430 YYANLPWIFYggFSIFNAFTVFL 452
Cdd:cd17432  346 LQNTVSWMPY--LSIVCIFAYIA 366
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 151-282 7.20e-05

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 44.87  E-value: 7.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 151 SFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFL 230
Cdd:cd17315   42 SLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIR 121

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 569007195 231 AMMAVLSSCAPNIGFMI--LAGLAFLFRIWHHLQLT---MSAPIFFFLILTRWLSES 282
Cdd:cd17315  122 GALGTLNQLMITFGILLayLLGLALSLSPPGWWRLMfalAAVPALLQLLLMFFLPES 178
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 125-276 9.59e-05

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 44.49  E-value: 9.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 125 SNFLSTIVTEWDlVCESQALNSVTkfSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRF 204
Cdd:cd17323   19 SPALPQIAEDFH-VSEEVANLGVS--LFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRF 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569007195 205 LAGM-SVEPISVNSHL---LMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFL--FRIWHHLQLTMSAPIFFFLILT 276
Cdd:cd17323   96 LQGFfGSSPLAIGAGTiadLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSlgWRWIFWFLAIISGFCLILIFLF 173
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 150-279 1.90e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 43.71  E-value: 1.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 150 FSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKF 229
Cdd:cd17319   45 SAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARE 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 569007195 230 LA-MMAVLSSCAP--NIGFMILAGLAFLFRIWHHLQLTMSAPIFFFLILTRWL 279
Cdd:cd17319  125 RGrATGLFNSGAPlgAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFY 177
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 154-300 2.84e-04

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 43.33  E-value: 2.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 154 IGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPkflAMM 233
Cdd:cd17433   52 LGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHP---RVR 128

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 234 AVLSSCAP---NIGFMiLAGLAFLFRIWHHLQLTMSAPIFFFLILTRWLSESARWLILINKPQKGLKELR 300
Cdd:cd17433  129 GTLGSCVQlmvVIGIM-GAYLAGLVLDWRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALR 197
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 158-444 4.11e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 42.51  E-value: 4.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 158 IGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSF--------FIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKF 229
Cdd:cd17369   59 LGGVVFGHFGDRIGRKKTLVLTLLLMGIATFLIGLLPTYaqigilapILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKR 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 230 LAMMAVLSSCAPNIGFMILAGLaflfriwhhlqltmsapiffFLILTRWLSESA--RW-----------LILInkpqkGL 296
Cdd:cd17369  139 RGFYGSFPQLGAPVGLLLATGV--------------------FLLLSALLSDEAflSWgwripfllsavLVAV-----GL 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 297 kelrkvahmngmknsgdltmeIVRTSM-------KAELEAAKTKPSLRDLFHTSilRKRICVLSFIRL-------FFTVS 362
Cdd:cd17369  194 ---------------------YIRLRLeetpvfrRAKEAGQVVRAPLVEVLRRH--WRALLLAIGLRLaenvlfyLFTTF 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 363 IIGLAVHLQHLSSNIILLQFLI-SALAILVSVIGPFVLNHIGRRITYLV--------------LMSLRGIFIMIAVFV-- 425
Cdd:cd17369  251 ALSYATQTLGVDRSTVLLAVLIaSVVAAITIPLFGWLSDRVGRRPVYLAgallaalfafpffwLLDTGSTWLIVLAAVvv 330

                        330       340       350
                 ....*....|....*....|....*....|.
gi 569007195 426 ----------PQATYYANL--PWIFYGGFSI 444
Cdd:cd17369  331 lgvlhgmmygPQAAFLAELfpTRVRYTGASL 361
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 129-254 1.30e-03

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 40.95  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 129 STIVTEWDLVCESQALnsVTKFSFMiGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGM 208
Cdd:cd17442   25 PEIRCEWHLEDWQVAL--VTTMVFF-GYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWFVFLRCMVGC 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 569007195 209 SVEPISvNSHLLMLEWTSPKFLAMMAVLSSCAPNIGFMILAGLAFL 254
Cdd:cd17442  102 GVSGHS-QGLIIKTEFLPTKYRGYMLPLSQIFWLAGSLLIIGLASV 146
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 157-283 1.36e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.06  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 157 FIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMS---VEPisVNSHLLMLEWTSPKFLAMM 233
Cdd:cd17329   49 IVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGgglFEP--ASEAMIADVTTPENRTRAF 126

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 569007195 234 AVLSSCApNIGFMILAGLAFLFRIWHHLQLTM---SAPIFFFLILTRWLSESA 283
Cdd:cd17329  127 SLLYWAI-NLGVAIGPLLGGLLLLYSFRLLFLaaaVLFLLAALVLLFLLPETR 178
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 157-208 1.49e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 40.70  E-value: 1.49e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 569007195 157 FIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGM 208
Cdd:cd17388   52 FIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGI 103
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 153-208 2.70e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 39.95  E-value: 2.70e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 569007195 153 MIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGM 208
Cdd:PRK11551  60 ILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGV 115
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 154-312 3.19e-03

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 39.78  E-value: 3.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 154 IGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAP--SFFIYCslRFLAGMSVE---PISVN------------ 216
Cdd:cd17363   45 LGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQgyGFFLFC--RLLSGIGIGgsiPIVFSyfaeflarekrg 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 217 ---SHLLMLEWTSPKFLAMMAvlSSCAPNIGFMILAGLAFLFRIWHHLQLTMSAPIFFFLILTRWLSESARWLILINKPQ 293
Cdd:cd17363  123 ehlSWLCMFWMIGGLYASAMA--WAIIPHYGWGFSMGTAYQFHSWRVFVIVCALPSVASVVALTFMPESPRFLLEVGKHD 200

                        170
                 ....*....|....*....
gi 569007195 294 KGLKELRKVaHMNGMKNSG 312
Cdd:cd17363  201 EAWMILKQV-HDTNMRAKG 218
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 150-457 3.27e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.88  E-value: 3.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 150 FSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKF 229
Cdd:cd17489   38 GLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSR 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 230 LAMMAVLSSCAPNIGFMILAGLAFLfrIWHHLQLTMSAPIFFFLILTRWLsesarwLILInkpqkglkelrkvahmngmk 309
Cdd:cd17489  118 RGEGIGYYGLATTLAMALGPALGLF--LYQHLGFAVLFIVAAVLALLALL------LVFL-------------------- 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 310 nsgdltmeivrtsMKAELEAAKTKPSLRDLFHTSILRKRICVLSFIRLF--FTVSIIG--LAVHLQHLSSNIILLQFLIS 385
Cdd:cd17489  170 -------------VKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLasIAYGAIStfLPLYAAERGISNAGLFFTVY 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 386 ALAILVSviGPFVLNHIGRRITYLVLMSlrGIFIMIAVFVpqATYYANLPWIFYGG-----------FSIFNAFTVFLLP 454
Cdd:cd17489  237 AIALLLS--RPFSGKLSDRKGPKTVIIP--GLLLLALGLL--LLSFAGSPWMLLLAavlyglgfgllFPALQALAVDLVP 310


                 ...
gi 569007195 455 ETK 457
Cdd:cd17489  311 PHR 313
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
152-244 4.46e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.19  E-value: 4.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 152 FMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLEWTSPKFLA 231
Cdd:COG2814  252 FGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARG 331

                         90
                 ....*....|...
gi 569007195 232 MMAVLSSCAPNIG 244
Cdd:COG2814  332 RASGLYNSAFFLG 344
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 150-210 4.80e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.08  E-value: 4.80e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569007195 150 FSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLrFLAGMSV 210
Cdd:cd17478  237 SLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLL 296
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 146-279 5.89e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 38.84  E-value: 5.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 146 SVTKFSFMIGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMS---VEPISVNSHLLML 222
Cdd:cd17333   34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGagiLDTGANTFVGALF 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 569007195 223 EWTSPKFLAMMAVLSSCAPNIGFMIlAGLAFLFRIWHHLqLTMSAPIFFFLILTRWL 279
Cdd:cd17333  114 EESSATRLNVLHGFFGLGALIGPLI-ATSLLTSELSWSW-AYLIIGLIYLLLAILIL 168
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 151-454 6.42e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 6.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 151 SFMIGLFigGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVEPISVNSHLLMLE-WTSPKF 229
Cdd:cd17473   45 ALFIALF--APLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDyFEGEER 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 230 LAMMAVLSSCAP--NIGFMILAGLAFLFRiWHHLQLTMSAPIFFFLILTRWLSESARwlilinkpqkglkelrkvahmng 307
Cdd:cd17473  123 AKMLGLQSAAMSlgGVVFLLLGGALAEIG-WRAPFLVYLLALPVLILVLLFLPEPAR----------------------- 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 308 mknsgdltMEIVRTSMKAELEAAKTKPSLrdlfhtsilrKRICVLSFIR--LFFTVsIIGLAVHLQHL----SSNIILLQ 381
Cdd:cd17473  179 --------KSKSAASPGAATAAALPWKRV----------LPIYFLAFLAmlLFYVI-PIQLPFLLQERgggsAALIGLAL 239

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569007195 382 FLISALAILVSVIGPFVLNHIGRRITYLVLMSLRGI-FIMIAVfvpqatyyANLPWIFYGGFSIFNAFTVFLLP 454
Cdd:cd17473  240 AIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALgFLLLAL--------ASGLWVVLLGAILAGLGFGLLLP 305
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 151-461 6.46e-03

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 38.77  E-value: 6.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 151 SFMIGLFIGGIICGHLSDRFGRKFIltcalLQFAITETCVAFAPSFFIYCSL------RFLAGMSVEPISVNSHLLMLEW 224
Cdd:cd17356   53 IVNLGSFFGALISSFLSDRIGRKKS-----IQIGCVIYIIGAIIQVAAIGKWyqlivgRIIAGLGVGFASVLVPVYQSEV 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 225 TSPKFLAMMAVLSSCAPNIGFMILA----GLAFL-----FRIWHHLQLtmsAPIFFFLILTRWLSESARWL----ILInk 291
Cdd:cd17356  128 APKHIRGTLVSLYQLAITIGILVAYcinyGTHKLdgsaqWRIPLGLQI---VWGLLLLIGMFFLPESPRWLyrtiLGI-- 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 292 pqkGLKELRKVAHMN-------------GMKNSGDLTMEIVRTSMKaeleAAKTKPSLrdLFHTSILRKRICVLSFIR-- 356
Cdd:cd17356  203 ---MLQLFQQLTGINyffyygttifqstGLTGSSPLLTSIILYIVN----FVSTIPGL--FFVDKFGRRTCLLIGAAGms 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 357 -LFFTVSIIG---LAVHLQHLSSN-------IILLQFLISALAI----LVSVIGPFVLNHIGRRITYLVLMSLRGIF-IM 420
Cdd:cd17356  274 iCLFIYAAVGvryLIPNPQSGTSNksagngmIVFICLFIFSFATtwgpIAWVYVAEVFPLRVRSKGMALATAFNWLWnFL 353

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 569007195 421 IAVFVPQATyyANLPW---IFYGGFSIFNAFTVFLL-PETKNQPL 461
Cdd:cd17356  354 ISFFTPFII--GSIGFkyyYIFAGCNLLAFIVVFFFvPETKGLTL 396
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 154-285 7.33e-03

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 38.91  E-value: 7.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007195 154 IGLFIGGIICGHLSDRFGRKFILTCALLQFAITETCVAFAPSFFIYCSLRFLAGMSVE-PISVNSHLLMLEWtsPKFL-- 230
Cdd:PRK03893  66 ISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAgEYGSSATYVIESW--PKHLrn 143

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569007195 231 -AMMAVLSscapniGFMILAGLA-FLFRI------WHHLQLTMSAPIFFFLILTRWLSESARW 285
Cdd:PRK03893 144 kASGFLIS------GFSIGAVVAaQVYSLvvpvwgWRALFFIGILPIIFALWLRKNLPEAEDW 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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