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Conserved domains on  [gi|569001527|ref|XP_006524938|]
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uncharacterized protein C6orf136 homolog isoform X1 [Mus musculus]

Protein Classification

DUF2358 domain-containing protein( domain architecture ID 10562819)

DUF2358 domain-containing protein belonging to the nuclear transport factor 2 superfamily, similar to human protein C6orf136

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF2358 pfam10184
Uncharacterized conserved protein (DUF2358); DUF2358 is a family of conserved proteins found ...
 242-367 2.44e-43

Uncharacterized conserved protein (DUF2358); DUF2358 is a family of conserved proteins found from plants to humans. The function is unknown.


:

Pssm-ID: 370865  Cd Length: 113  Bit Score: 147.02  E-value: 2.44e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001527  242 AVMHERLRQELPTLFLRSHDYTIYSMDVEFINEIlnIRTKGRTFYVMSLTLCRFLVWNYFAQFRLEILQLTRHPEnWTLQ 321
Cdd:pfam10184   1 ADVVEILREDLPRLFPKDQDYSIYSEDVYFIDPL--NKFRGIDRYKKMFWAIRFLGRLFFADISLELHDITQHGD-NTIK 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 569001527  322 ARWRLIGLPIHmlflrFYRRDKedlyrTFDAFSTFYLNSSGLICRH 367
Cdd:pfam10184  78 TRWTLRGIPPL-----PWKPRI-----TFDGTSEYKLNADGLIYSH 113
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 122-231 3.43e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.30  E-value: 3.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001527  122 PRPLPFPPLWPHSTPPTSPSFPPHRsLPPSHPPTHHLPQAPPPPLSQAQALnslsmvlpPRKREKGPGPELHSGCLDGLR 201
Cdd:pfam03154 217 PPNQTQSTAAPHTLIQQTPTLHPQR-LPSPHPPLQPMTQPPPPSQVSPQPL--------PQPSLHGQMPPMPHSLQTGPS 287

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 569001527  202 SL-FEGPPCPYP-------GAVIP---FQAPGPSHSSPTTP 231
Cdd:pfam03154 288 HMqHPVPPQPFPltpqssqSQVPPgpsPAAPGQSQQRIHTP 328
 
Name Accession Description Interval E-value
DUF2358 pfam10184
Uncharacterized conserved protein (DUF2358); DUF2358 is a family of conserved proteins found ...
 242-367 2.44e-43

Uncharacterized conserved protein (DUF2358); DUF2358 is a family of conserved proteins found from plants to humans. The function is unknown.


Pssm-ID: 370865  Cd Length: 113  Bit Score: 147.02  E-value: 2.44e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001527  242 AVMHERLRQELPTLFLRSHDYTIYSMDVEFINEIlnIRTKGRTFYVMSLTLCRFLVWNYFAQFRLEILQLTRHPEnWTLQ 321
Cdd:pfam10184   1 ADVVEILREDLPRLFPKDQDYSIYSEDVYFIDPL--NKFRGIDRYKKMFWAIRFLGRLFFADISLELHDITQHGD-NTIK 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 569001527  322 ARWRLIGLPIHmlflrFYRRDKedlyrTFDAFSTFYLNSSGLICRH 367
Cdd:pfam10184  78 TRWTLRGIPPL-----PWKPRI-----TFDGTSEYKLNADGLIYSH 113
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 122-231 3.43e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.30  E-value: 3.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001527  122 PRPLPFPPLWPHSTPPTSPSFPPHRsLPPSHPPTHHLPQAPPPPLSQAQALnslsmvlpPRKREKGPGPELHSGCLDGLR 201
Cdd:pfam03154 217 PPNQTQSTAAPHTLIQQTPTLHPQR-LPSPHPPLQPMTQPPPPSQVSPQPL--------PQPSLHGQMPPMPHSLQTGPS 287

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 569001527  202 SL-FEGPPCPYP-------GAVIP---FQAPGPSHSSPTTP 231
Cdd:pfam03154 288 HMqHPVPPQPFPltpqssqSQVPPgpsPAAPGQSQQRIHTP 328
PHA03247 PHA03247
large tegument protein UL36; Provisional
 114-240 7.81e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.77  E-value: 7.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001527  114 SLLQDQLSPRPLPFPPLwPHSTPPTSPSFPPHRSLPPshPPTHHLPQAPPPPLSQAQALNSLSMVLpprkrekgPGPELh 193
Cdd:PHA03247 2897 SFALPPDQPERPPQPQA-PPPPQPQPQPPPPPQPQPP--PPPPPRPQPPLAPTTDPAGAGEPSGAV--------PQPWL- 2964

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 569001527  194 sgcldglrslfeGPPCPYPGAVIPFQAPGPSHSSPTTPSGDESMEEH 240
Cdd:PHA03247 2965 ------------GALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGH 2999
 
Name Accession Description Interval E-value
DUF2358 pfam10184
Uncharacterized conserved protein (DUF2358); DUF2358 is a family of conserved proteins found ...
 242-367 2.44e-43

Uncharacterized conserved protein (DUF2358); DUF2358 is a family of conserved proteins found from plants to humans. The function is unknown.


Pssm-ID: 370865  Cd Length: 113  Bit Score: 147.02  E-value: 2.44e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001527  242 AVMHERLRQELPTLFLRSHDYTIYSMDVEFINEIlnIRTKGRTFYVMSLTLCRFLVWNYFAQFRLEILQLTRHPEnWTLQ 321
Cdd:pfam10184   1 ADVVEILREDLPRLFPKDQDYSIYSEDVYFIDPL--NKFRGIDRYKKMFWAIRFLGRLFFADISLELHDITQHGD-NTIK 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 569001527  322 ARWRLIGLPIHmlflrFYRRDKedlyrTFDAFSTFYLNSSGLICRH 367
Cdd:pfam10184  78 TRWTLRGIPPL-----PWKPRI-----TFDGTSEYKLNADGLIYSH 113
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 122-231 3.43e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 46.30  E-value: 3.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001527  122 PRPLPFPPLWPHSTPPTSPSFPPHRsLPPSHPPTHHLPQAPPPPLSQAQALnslsmvlpPRKREKGPGPELHSGCLDGLR 201
Cdd:pfam03154 217 PPNQTQSTAAPHTLIQQTPTLHPQR-LPSPHPPLQPMTQPPPPSQVSPQPL--------PQPSLHGQMPPMPHSLQTGPS 287

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 569001527  202 SL-FEGPPCPYP-------GAVIP---FQAPGPSHSSPTTP 231
Cdd:pfam03154 288 HMqHPVPPQPFPltpqssqSQVPPgpsPAAPGQSQQRIHTP 328
PHA03247 PHA03247
large tegument protein UL36; Provisional
 114-240 7.81e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.77  E-value: 7.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001527  114 SLLQDQLSPRPLPFPPLwPHSTPPTSPSFPPHRSLPPshPPTHHLPQAPPPPLSQAQALNSLSMVLpprkrekgPGPELh 193
Cdd:PHA03247 2897 SFALPPDQPERPPQPQA-PPPPQPQPQPPPPPQPQPP--PPPPPRPQPPLAPTTDPAGAGEPSGAV--------PQPWL- 2964

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 569001527  194 sgcldglrslfeGPPCPYPGAVIPFQAPGPSHSSPTTPSGDESMEEH 240
Cdd:PHA03247 2965 ------------GALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGH 2999
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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