NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|569000987|ref|XP_006524677|]
View 

uromodulin-like 1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
996-1236 2.57e-37

Zona pellucida-like domain;


:

Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 141.20  E-value: 2.57e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000987   996 CEIETVIITIQKRFLQQAAIPEaSLYLG---EPSCNVSRSN--STHVFLVAGWGECGTILQSNMTTTVVTTTLRNNLSPE 1070
Cdd:pfam00100    1 CTPDTMTVSISKCLLVPSGLLS-SLSLLgglDPSCKPVSNTngSPAVLFEFPLTGCGTTVQVNGTHIIYSNTLYSSTDLR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000987  1071 GVIHHPQFLS--PIHCAFQNDVLTSSGYTPQWGVYTVIEDlhGTGNFVTEMQLYIGDS----PIPQNYSVSASDEIKIEV 1144
Cdd:pfam00100   80 SGIIRRTITRrlPFSCSYPRSSLVSLLVVAPPSPVPITVS--GSGVFLVSMDLYYDSSytspYSPYPVTVLLGDPLYVEV 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000987  1145 GL-HRQKSSLKVVLTECWATPSSNAKDPVTFSFINNSCPVPNTYT---SVIQNGHSSKAQFKLRIFSFINNSI--VYLHC 1218
Cdd:pfam00100  158 SLlSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTypvSSLSNGPSHYVRFSFKAFRFVGSSIsqVYLHC 237

                          250
                   ....*....|....*...
gi 569000987  1219 KLRVCMENPrNSCRISCN 1236
Cdd:pfam00100  238 SVSVCSSDS-NSCGKSCS 254
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 118-158 1.21e-09

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


:

Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 54.74  E-value: 1.21e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 569000987   118 RPGVCPTAEAEPLSPS-CSLDTDCSGLQKCCSWPGGRHCVSP 158
Cdd:pfam00095    1 KPGCCPRLGARGCCRScCSSDDDCPGRQKCCSNGCGSVCVPP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
502-529 1.68e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 1.68e-06
                            10        20
                    ....*....|....*....|....*...
gi 569000987    502 DECAhsSEHDCHPSARCINLEGSYTCQC 529
Cdd:smart00179    3 DECA--SGNPCQNGGTCVNTVGSYRCEC 28
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 901-944 3.04e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 3.04e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 569000987  901 DYNECDMkEDDCAP-GTCRNTFGSFTCSCDEGgpdsqveYSGRSC 944
Cdd:cd00054     1 DIDECAS-GNPCQNgGTCVNTVGSYRCSCPPG-------YTGRNC 37
SEA super family cl02507
SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed ...
 800-866 6.66e-06

SEA domain; Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains. Recently a proteolytic activity has been shown for a SEA domain.


The actual alignment was detected with superfamily member smart00200:

Pssm-ID: 470595  Cd Length: 121  Bit Score: 46.64  E-value: 6.66e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569000987    800 VRITSMQYSESFLNTSSREHREFVELFFRTVRDSLPATLrqhMDAGRIRVDIINITNGSIVVEFNLL 866
Cdd:smart00200   14 VEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTD---LKPDFVGTEVIEFRNGSVVVDLGLL 77
fn3 pfam00041
Fibronectin type III domain;
708-785 1.48e-04

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 41.63  E-value: 1.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000987   708 GPIGKVTVSNVTSTSFSLEW-PADIRLSP--AFHLTLVSPRGPAMTMETQN----NNVTLSGLEWGTLYLVEIVAKVCGK 780
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtPPPDGNGPitGYEVEYRPKNSGEPWNEITVpgttTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 569000987   781 EGART 785
Cdd:pfam00041   81 EGPPS 85
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 306-370 1.78e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam00041:

Pssm-ID: 473895 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 1.78e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569000987   306 PPIRDFVALNVTSSSFHVSWSLNSTQN---YNFHIQVYKGKEILRSAWTRG----HTMAVSDLEAGVLYRVR 370
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSGEPWNEITVpgttTSVTLTGLKPGTEYEVR 72
EGF_CA smart00179
Calcium-binding EGF-like domain;
265-293 7.65e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 7.65e-03
                            10        20
                    ....*....|....*....|....*....
gi 569000987    265 DVNEClhSELQACSVREQCRNLEGSYQCV 293
Cdd:smart00179    1 DIDEC--ASGNPCQNGGTCVNTVGSYRCE 27
 
Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
996-1236 2.57e-37

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 141.20  E-value: 2.57e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000987   996 CEIETVIITIQKRFLQQAAIPEaSLYLG---EPSCNVSRSN--STHVFLVAGWGECGTILQSNMTTTVVTTTLRNNLSPE 1070
Cdd:pfam00100    1 CTPDTMTVSISKCLLVPSGLLS-SLSLLgglDPSCKPVSNTngSPAVLFEFPLTGCGTTVQVNGTHIIYSNTLYSSTDLR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000987  1071 GVIHHPQFLS--PIHCAFQNDVLTSSGYTPQWGVYTVIEDlhGTGNFVTEMQLYIGDS----PIPQNYSVSASDEIKIEV 1144
Cdd:pfam00100   80 SGIIRRTITRrlPFSCSYPRSSLVSLLVVAPPSPVPITVS--GSGVFLVSMDLYYDSSytspYSPYPVTVLLGDPLYVEV 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000987  1145 GL-HRQKSSLKVVLTECWATPSSNAKDPVTFSFINNSCPVPNTYT---SVIQNGHSSKAQFKLRIFSFINNSI--VYLHC 1218
Cdd:pfam00100  158 SLlSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTypvSSLSNGPSHYVRFSFKAFRFVGSSIsqVYLHC 237

                          250
                   ....*....|....*...
gi 569000987  1219 KLRVCMENPrNSCRISCN 1236
Cdd:pfam00100  238 SVSVCSSDS-NSCGKSCS 254
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 996-1236 3.20e-29

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 117.87  E-value: 3.20e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000987    996 CEIETVIITIQKRFLQQAAIPEASLYLGEPSCNV--SRSNSTHVFLVAGWGECGTILQSNmtttvvtttlrnnlsPEGVI 1073
Cdd:smart00241    2 CGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPqfTDATSAFVSFEVPLNGCGTRRQVN---------------PDGIV 66

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000987   1074 ---------HHPQFLS-------PIHCAFQNDVLTSSGYTPQWGVYTVIEDLhGTGNFVTEMQLYIGD--SPIPQNYSVS 1135
Cdd:smart00241   67 ysntlvvspFHPGFITrddraayHFQCFYPENEKVSLNLDVSTIPPTELSSV-SEGPLTCSYRLYKDDsfGSPYQSADYV 145

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000987   1136 ASDEIKIEVGLHRQKS-SLKVVLTECWATPSSNAKDPVTFSFINNSCPVPNTYTSVI--QNGHSSKAQFKLRIFSFINNS 1212
Cdd:smart00241  146 LGDPVYHEWECDGADDpPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPVDGYLDSTIpyNSNPLHRARFSVKVFKFADRS 225

                           250       260
                    ....*....|....*....|....*
gi 569000987   1213 IVYLHCKLRVCMENPRNSC-RISCN 1236
Cdd:smart00241  226 LVYFHCQIRLCDKDDGSSCdGPACS 250
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 118-158 1.21e-09

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 54.74  E-value: 1.21e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 569000987   118 RPGVCPTAEAEPLSPS-CSLDTDCSGLQKCCSWPGGRHCVSP 158
Cdd:pfam00095    1 KPGCCPRLGARGCCRScCSSDDDCPGRQKCCSNGCGSVCVPP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
502-529 1.68e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 1.68e-06
                            10        20
                    ....*....|....*....|....*...
gi 569000987    502 DECAhsSEHDCHPSARCINLEGSYTCQC 529
Cdd:smart00179    3 DECA--SGNPCQNGGTCVNTVGSYRCEC 28
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 502-529 1.83e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.83e-06
                          10        20
                  ....*....|....*....|....*...
gi 569000987  502 DECAhsSEHDCHPSARCINLEGSYTCQC 529
Cdd:cd00054     3 DECA--SGNPCQNGGTCVNTVGSYRCSC 28
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 901-944 3.04e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 3.04e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 569000987  901 DYNECDMkEDDCAP-GTCRNTFGSFTCSCDEGgpdsqveYSGRSC 944
Cdd:cd00054     1 DIDECAS-GNPCQNgGTCVNTVGSYRCSCPPG-------YTGRNC 37
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 800-866 6.66e-06

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 46.64  E-value: 6.66e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569000987    800 VRITSMQYSESFLNTSSREHREFVELFFRTVRDSLPATLrqhMDAGRIRVDIINITNGSIVVEFNLL 866
Cdd:smart00200   14 VEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTD---LKPDFVGTEVIEFRNGSVVVDLGLL 77
EGF_CA pfam07645
Calcium-binding EGF domain;
500-529 1.07e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 43.38  E-value: 1.07e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 569000987   500 DWDECAhSSEHDCHPSARCINLEGSYTCQC 529
Cdd:pfam07645    1 DVDECA-TGTHNCPANTVCVNTIGSFECRC 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
901-931 5.32e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 5.32e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 569000987    901 DYNECDMKeDDCAPG-TCRNTFGSFTCSCDEG 931
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPG 31
EGF_CA pfam07645
Calcium-binding EGF domain;
901-931 5.43e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.45  E-value: 5.43e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569000987   901 DYNECDMKEDDCAPGT-CRNTFGSFTCSCDEG 931
Cdd:pfam07645    1 DVDECATGTHNCPANTvCVNTIGSFECRCPDG 32
WAP smart00217
Four-disulfide core domains;
118-158 1.44e-04

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 40.43  E-value: 1.44e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 569000987    118 RPGVCP---TAEAEPLSP--SCSLDTDCSGLQKCCSWPGGRHCVSP 158
Cdd:smart00217    1 KPGSCPwptIASCPLGNPpnKCSSDSQCPGVKKCCFNGCGKSCLTP 46
fn3 pfam00041
Fibronectin type III domain;
708-785 1.48e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 41.63  E-value: 1.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000987   708 GPIGKVTVSNVTSTSFSLEW-PADIRLSP--AFHLTLVSPRGPAMTMETQN----NNVTLSGLEWGTLYLVEIVAKVCGK 780
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtPPPDGNGPitGYEVEYRPKNSGEPWNEITVpgttTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 569000987   781 EGART 785
Cdd:pfam00041   81 EGPPS 85
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 118-158 4.59e-04

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 39.74  E-value: 4.59e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 569000987  118 RPGVCPTAEAEPLSP---SCSLDTDCSGLQKCCSWPGGRHCVSP 158
Cdd:cd00199    16 KPGRCPMVNPPSLGIppnRCSSDSDCPGDKKCCENGCGKSCLTP 59
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 707-776 7.27e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 7.27e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569000987    707 PGPIGKVTVSNVTSTSFSLEW---PADIRLSPAFHLTLVSPRGPA----MTMETQNNNVTLSGLEWGTLYLVEIVAK 776
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWeppPDDGITGYIVGYRVEYREEGSewkeVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 707-783 1.43e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.02  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000987  707 PGPIGKVTVSNVTSTSFSLEW-PADIRLSPAFHLTLV---SPRGPAMTMETQNNN---VTLSGLEWGTLYLVEIVAKVCG 779
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWtPPEDDGGPITGYVVEyreKGSGDWKEVEVTPGSetsYTLTGLKPGTEYEFRVRAVNGG 80


                  ....
gi 569000987  780 KEGA 783
Cdd:cd00063    81 GESP 84
fn3 pfam00041
Fibronectin type III domain;
306-370 1.78e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 1.78e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569000987   306 PPIRDFVALNVTSSSFHVSWSLNSTQN---YNFHIQVYKGKEILRSAWTRG----HTMAVSDLEAGVLYRVR 370
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSGEPWNEITVpgttTSVTLTGLKPGTEYEVR 72
EGF_CA smart00179
Calcium-binding EGF-like domain;
265-293 7.65e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 7.65e-03
                            10        20
                    ....*....|....*....|....*....
gi 569000987    265 DVNEClhSELQACSVREQCRNLEGSYQCV 293
Cdd:smart00179    1 DIDEC--ASGNPCQNGGTCVNTVGSYRCE 27
 
Name Accession Description Interval E-value
Zona_pellucida pfam00100
Zona pellucida-like domain;
996-1236 2.57e-37

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 141.20  E-value: 2.57e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000987   996 CEIETVIITIQKRFLQQAAIPEaSLYLG---EPSCNVSRSN--STHVFLVAGWGECGTILQSNMTTTVVTTTLRNNLSPE 1070
Cdd:pfam00100    1 CTPDTMTVSISKCLLVPSGLLS-SLSLLgglDPSCKPVSNTngSPAVLFEFPLTGCGTTVQVNGTHIIYSNTLYSSTDLR 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000987  1071 GVIHHPQFLS--PIHCAFQNDVLTSSGYTPQWGVYTVIEDlhGTGNFVTEMQLYIGDS----PIPQNYSVSASDEIKIEV 1144
Cdd:pfam00100   80 SGIIRRTITRrlPFSCSYPRSSLVSLLVVAPPSPVPITVS--GSGVFLVSMDLYYDSSytspYSPYPVTVLLGDPLYVEV 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000987  1145 GL-HRQKSSLKVVLTECWATPSSNAKDPVTFSFINNSCPVPNTYT---SVIQNGHSSKAQFKLRIFSFINNSI--VYLHC 1218
Cdd:pfam00100  158 SLlSRTDPNLVLVLDNCWATPSPNPTSSPQYQLIVNGCPNDGDSTypvSSLSNGPSHYVRFSFKAFRFVGSSIsqVYLHC 237

                          250
                   ....*....|....*...
gi 569000987  1219 KLRVCMENPrNSCRISCN 1236
Cdd:pfam00100  238 SVSVCSSDS-NSCGKSCS 254
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 996-1236 3.20e-29

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 117.87  E-value: 3.20e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000987    996 CEIETVIITIQKRFLQQAAIPEASLYLGEPSCNV--SRSNSTHVFLVAGWGECGTILQSNmtttvvtttlrnnlsPEGVI 1073
Cdd:smart00241    2 CGEDQMVVSVSTDLLFPGGINVKGLTLGDPSCRPqfTDATSAFVSFEVPLNGCGTRRQVN---------------PDGIV 66

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000987   1074 ---------HHPQFLS-------PIHCAFQNDVLTSSGYTPQWGVYTVIEDLhGTGNFVTEMQLYIGD--SPIPQNYSVS 1135
Cdd:smart00241   67 ysntlvvspFHPGFITrddraayHFQCFYPENEKVSLNLDVSTIPPTELSSV-SEGPLTCSYRLYKDDsfGSPYQSADYV 145

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000987   1136 ASDEIKIEVGLHRQKS-SLKVVLTECWATPSSNAKDPVTFSFINNSCPVPNTYTSVI--QNGHSSKAQFKLRIFSFINNS 1212
Cdd:smart00241  146 LGDPVYHEWECDGADDpPLGLLVDNCYATPGPDPSSGPKYFIIDNGCPVDGYLDSTIpyNSNPLHRARFSVKVFKFADRS 225

                           250       260
                    ....*....|....*....|....*
gi 569000987   1213 IVYLHCKLRVCMENPRNSC-RISCN 1236
Cdd:smart00241  226 LVYFHCQIRLCDKDDGSSCdGPACS 250
WAP pfam00095
WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or ...
 118-158 1.21e-09

WAP-type (Whey Acidic Protein) 'four-disulfide core'; WAP belongs to the group of Elafin or elastase-specific inhibitors.


Pssm-ID: 459672 [Multi-domain]  Cd Length: 42  Bit Score: 54.74  E-value: 1.21e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 569000987   118 RPGVCPTAEAEPLSPS-CSLDTDCSGLQKCCSWPGGRHCVSP 158
Cdd:pfam00095    1 KPGCCPRLGARGCCRScCSSDDDCPGRQKCCSNGCGSVCVPP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
502-529 1.68e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 1.68e-06
                            10        20
                    ....*....|....*....|....*...
gi 569000987    502 DECAhsSEHDCHPSARCINLEGSYTCQC 529
Cdd:smart00179    3 DECA--SGNPCQNGGTCVNTVGSYRCEC 28
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 502-529 1.83e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 1.83e-06
                          10        20
                  ....*....|....*....|....*...
gi 569000987  502 DECAhsSEHDCHPSARCINLEGSYTCQC 529
Cdd:cd00054     3 DECA--SGNPCQNGGTCVNTVGSYRCSC 28
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 901-944 3.04e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 3.04e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 569000987  901 DYNECDMkEDDCAP-GTCRNTFGSFTCSCDEGgpdsqveYSGRSC 944
Cdd:cd00054     1 DIDECAS-GNPCQNgGTCVNTVGSYRCSCPPG-------YTGRNC 37
SEA smart00200
Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating ...
 800-866 6.66e-06

Domain found in sea urchin sperm protein, enterokinase, agrin; Proposed function of regulating or binding carbohydrate sidechains.


Pssm-ID: 214554  Cd Length: 121  Bit Score: 46.64  E-value: 6.66e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569000987    800 VRITSMQYSESFLNTSSREHREFVELFFRTVRDSLPATLrqhMDAGRIRVDIINITNGSIVVEFNLL 866
Cdd:smart00200   14 VEGENLQYSPSLEDPSSEEYQELVRDVEKLLEQIYGKTD---LKPDFVGTEVIEFRNGSVVVDLGLL 77
EGF_CA pfam07645
Calcium-binding EGF domain;
500-529 1.07e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 43.38  E-value: 1.07e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 569000987   500 DWDECAhSSEHDCHPSARCINLEGSYTCQC 529
Cdd:pfam07645    1 DVDECA-TGTHNCPANTVCVNTIGSFECRC 29
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 504-529 4.67e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.82  E-value: 4.67e-05
                           10        20
                   ....*....|....*....|....*.
gi 569000987   504 CAHSSeHDCHPSARCINLEGSYTCQC 529
Cdd:pfam12947    1 CSDNN-GGCHPNATCTNTGGSFTCTC 25
EGF_CA smart00179
Calcium-binding EGF-like domain;
901-931 5.32e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 5.32e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 569000987    901 DYNECDMKeDDCAPG-TCRNTFGSFTCSCDEG 931
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPG 31
EGF_CA pfam07645
Calcium-binding EGF domain;
901-931 5.43e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.45  E-value: 5.43e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 569000987   901 DYNECDMKEDDCAPGT-CRNTFGSFTCSCDEG 931
Cdd:pfam07645    1 DVDECATGTHNCPANTvCVNTIGSFECRCPDG 32
WAP smart00217
Four-disulfide core domains;
118-158 1.44e-04

Four-disulfide core domains;


Pssm-ID: 197580 [Multi-domain]  Cd Length: 47  Bit Score: 40.43  E-value: 1.44e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 569000987    118 RPGVCP---TAEAEPLSP--SCSLDTDCSGLQKCCSWPGGRHCVSP 158
Cdd:smart00217    1 KPGSCPwptIASCPLGNPpnKCSSDSQCPGVKKCCFNGCGKSCLTP 46
fn3 pfam00041
Fibronectin type III domain;
708-785 1.48e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 41.63  E-value: 1.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000987   708 GPIGKVTVSNVTSTSFSLEW-PADIRLSP--AFHLTLVSPRGPAMTMETQN----NNVTLSGLEWGTLYLVEIVAKVCGK 780
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtPPPDGNGPitGYEVEYRPKNSGEPWNEITVpgttTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 569000987   781 EGART 785
Cdd:pfam00041   81 EGPPS 85
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 503-529 4.12e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.00  E-value: 4.12e-04
                          10        20
                  ....*....|....*....|....*..
gi 569000987  503 ECAHSseHDCHPSARCINLEGSYTCQC 529
Cdd:cd00053     1 ECAAS--NPCSNGGTCVNTPGSYRCVC 25
WAP cd00199
whey acidic protein-type four-disulfide core domains. Members of the family include whey ...
 118-158 4.59e-04

whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of proteins containing 8 characteristically-spaced cysteine residuesforming disulphide bonds, have been termed '4-disulphide core' proteins. Protease inhibition occurs by insertion of the inhibitory loop into the active site pocket and interference with the catalytic residues of the protease.


Pssm-ID: 238120 [Multi-domain]  Cd Length: 60  Bit Score: 39.74  E-value: 4.59e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 569000987  118 RPGVCPTAEAEPLSP---SCSLDTDCSGLQKCCSWPGGRHCVSP 158
Cdd:cd00199    16 KPGRCPMVNPPSLGIppnRCSSDSDCPGDKKCCENGCGKSCLTP 59
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 707-776 7.27e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 7.27e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569000987    707 PGPIGKVTVSNVTSTSFSLEW---PADIRLSPAFHLTLVSPRGPA----MTMETQNNNVTLSGLEWGTLYLVEIVAK 776
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWeppPDDGITGYIVGYRVEYREEGSewkeVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 707-783 1.43e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.02  E-value: 1.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569000987  707 PGPIGKVTVSNVTSTSFSLEW-PADIRLSPAFHLTLV---SPRGPAMTMETQNNN---VTLSGLEWGTLYLVEIVAKVCG 779
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWtPPEDDGGPITGYVVEyreKGSGDWKEVEVTPGSetsYTLTGLKPGTEYEFRVRAVNGG 80


                  ....
gi 569000987  780 KEGA 783
Cdd:cd00063    81 GESP 84
fn3 pfam00041
Fibronectin type III domain;
306-370 1.78e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.55  E-value: 1.78e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569000987   306 PPIRDFVALNVTSSSFHVSWSLNSTQN---YNFHIQVYKGKEILRSAWTRG----HTMAVSDLEAGVLYRVR 370
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNgpiTGYEVEYRPKNSGEPWNEITVpgttTSVTLTGLKPGTEYEVR 72
EGF smart00181
Epidermal growth factor-like domain;
904-931 2.83e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 36.73  E-value: 2.83e-03
                            10        20
                    ....*....|....*....|....*...
gi 569000987    904 ECDMKeDDCAPGTCRNTFGSFTCSCDEG 931
Cdd:smart00181    1 ECASG-GPCSNGTCINTPGSYTCSCPPG 27
EGF_CA smart00179
Calcium-binding EGF-like domain;
265-293 7.65e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 7.65e-03
                            10        20
                    ....*....|....*....|....*....
gi 569000987    265 DVNEClhSELQACSVREQCRNLEGSYQCV 293
Cdd:smart00179    1 DIDEC--ASGNPCQNGGTCVNTVGSYRCE 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH