NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568999354|ref|XP_006523883|]
View 

histone acetyltransferase KAT2B isoform X1 [Mus musculus]

Protein Classification

PCAF_N and Bromo_gcn5_like domain-containing protein( domain architecture ID 13721335)

protein containing domains PCAF_N, NAT_SF, and Bromo_gcn5_like

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PCAF_N pfam06466
PCAF (P300/CBP-associated factor) N-terminal domain; This region is spliced out of Swiss: ...
 1-168 1.07e-101

PCAF (P300/CBP-associated factor) N-terminal domain; This region is spliced out of Swiss:Q92830 isoform 2. It is predicted to be of a mixed alpha/beta fold - though predominantly helical.


:

Pssm-ID: 461923  Cd Length: 249  Bit Score: 310.78  E-value: 1.07e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354    1 MDRLLGIVLDVEYLFTCVHKEEDADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKkPPFEKPSIEQGVNNFVQYKFSHLP 80
Cdd:pfam06466  83 LNRLLGMVVDVENLFMSVHKEEDADTKQVYFYLFKLLRKCILSMTKPVIEGPLGQ-PPFERPSIAKAVMNFVLYKFSHLP 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354   81 SKERQTTIELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPRYETTKVFGRTLLRSVFT 160
Cdd:pfam06466 162 QREWQTMYDLAKMFLHCLNHWNFETPSARKQRAKAEDASAYKINYTRWLCFCHVPAFCDSLPHYETTLVFGRTLLRAVFK 241


                  ....*...
gi 568999354  161 IMRRQLLE 168
Cdd:pfam06466 242 VVRRQLLD 249
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 569-668 4.49e-54

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 180.06  E-value: 4.49e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 569 QLYSTLKNILQQVKNHPNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPE 648
Cdd:cd05509    1 PLYTQLKKVLDSLKNHKSAWPFLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPD 80

                         90       100
                 ....*....|....*....|
gi 568999354 649 SEYYKCASILEKFFFSKIKE 668
Cdd:cd05509   81 TEYYKCANKLEKFFWKKLKE 100
COG5076 super family cl34891
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 329-668 5.22e-39

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


The actual alignment was detected with superfamily member COG5076:

Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 148.03  E-value: 5.22e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 329 LEERRGVIEFHVVGNSLNQKPNKKILMwlvGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALI-KDGRVIGGICFRMF-- 405
Cdd:COG5076   17 LKEEFGNELLRLVDNDSSPFPNAPEEE---GSKNLFQKQLKRMPKEYITSIVDDREPGSMANVnDDLENVGGITYSPFek 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 406 ---PSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKH---EILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYI 479
Cdd:COG5076   94 nrpESLRFDEIVFLAIESVTPESGLGSLLMAHLKTSVKKRktpKIEDELLYADNKAIAKFKKQLFLRDGRFLSSIFLGLP 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 480 KDYEGATLMGCELNPqIPYTEFsviikkqkeiikklieRKQAQIRKvYPGLSCFKDGVRQI---------PIESIPGIRE 550
Cdd:COG5076  174 SKREYPDYYEIIKSP-MDLLTI----------------QKKLKNGR-YKSFEEFVSDLNLMfdncklyngPDSSVYVDAK 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 551 TGWKPSGKEKSKEPKDPEQLYSTLKN---------ILQQVKNHPNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRN 621
Cdd:COG5076  236 ELEKYFLKLIEEIPEEMLELSIKPGReereeresvLITNSQAHVGAWPFLRPVSDEEVPDYYKDIRDPMDLSTKELKLRN 315

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 568999354 622 RYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCASILEKFFFSKIKE 668
Cdd:COG5076  316 NYYRPEETFVRDAKLFFDNCVMYNGEVTDYYKNANVLEDFVIKKTRL 362
 
Name Accession Description Interval E-value
PCAF_N pfam06466
PCAF (P300/CBP-associated factor) N-terminal domain; This region is spliced out of Swiss: ...
 1-168 1.07e-101

PCAF (P300/CBP-associated factor) N-terminal domain; This region is spliced out of Swiss:Q92830 isoform 2. It is predicted to be of a mixed alpha/beta fold - though predominantly helical.


Pssm-ID: 461923  Cd Length: 249  Bit Score: 310.78  E-value: 1.07e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354    1 MDRLLGIVLDVEYLFTCVHKEEDADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKkPPFEKPSIEQGVNNFVQYKFSHLP 80
Cdd:pfam06466  83 LNRLLGMVVDVENLFMSVHKEEDADTKQVYFYLFKLLRKCILSMTKPVIEGPLGQ-PPFERPSIAKAVMNFVLYKFSHLP 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354   81 SKERQTTIELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPRYETTKVFGRTLLRSVFT 160
Cdd:pfam06466 162 QREWQTMYDLAKMFLHCLNHWNFETPSARKQRAKAEDASAYKINYTRWLCFCHVPAFCDSLPHYETTLVFGRTLLRAVFK 241


                  ....*...
gi 568999354  161 IMRRQLLE 168
Cdd:pfam06466 242 VVRRQLLD 249
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 569-668 4.49e-54

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 180.06  E-value: 4.49e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 569 QLYSTLKNILQQVKNHPNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPE 648
Cdd:cd05509    1 PLYTQLKKVLDSLKNHKSAWPFLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPD 80

                         90       100
                 ....*....|....*....|
gi 568999354 649 SEYYKCASILEKFFFSKIKE 668
Cdd:cd05509   81 TEYYKCANKLEKFFWKKLKE 100
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 329-668 5.22e-39

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 148.03  E-value: 5.22e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 329 LEERRGVIEFHVVGNSLNQKPNKKILMwlvGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALI-KDGRVIGGICFRMF-- 405
Cdd:COG5076   17 LKEEFGNELLRLVDNDSSPFPNAPEEE---GSKNLFQKQLKRMPKEYITSIVDDREPGSMANVnDDLENVGGITYSPFek 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 406 ---PSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKH---EILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYI 479
Cdd:COG5076   94 nrpESLRFDEIVFLAIESVTPESGLGSLLMAHLKTSVKKRktpKIEDELLYADNKAIAKFKKQLFLRDGRFLSSIFLGLP 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 480 KDYEGATLMGCELNPqIPYTEFsviikkqkeiikklieRKQAQIRKvYPGLSCFKDGVRQI---------PIESIPGIRE 550
Cdd:COG5076  174 SKREYPDYYEIIKSP-MDLLTI----------------QKKLKNGR-YKSFEEFVSDLNLMfdncklyngPDSSVYVDAK 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 551 TGWKPSGKEKSKEPKDPEQLYSTLKN---------ILQQVKNHPNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRN 621
Cdd:COG5076  236 ELEKYFLKLIEEIPEEMLELSIKPGReereeresvLITNSQAHVGAWPFLRPVSDEEVPDYYKDIRDPMDLSTKELKLRN 315

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 568999354 622 RYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCASILEKFFFSKIKE 668
Cdd:COG5076  316 NYYRPEETFVRDAKLFFDNCVMYNGEVTDYYKNANVLEDFVIKKTRL 362
BROMO smart00297
bromo domain;
563-669 7.35e-38

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 136.25  E-value: 7.35e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354   563 EPKDPEQLYSTLKNILQQVKNHPNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCK 642
Cdd:smart00297   1 DPKLQKKLQELLKAVLDKLDSHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNAR 80

                           90       100
                   ....*....|....*....|....*..
gi 568999354   643 EYNPPESEYYKCASILEKFFFSKIKEA 669
Cdd:smart00297  81 TYNGPDSEVYKDAKKLEKFFEKKLREL 107
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 574-655 1.22e-24

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 97.77  E-value: 1.22e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354  574 LKNILQQVKNHPNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYK 653
Cdd:pfam00439   1 CLEILDKLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYK 80


                  ..
gi 568999354  654 CA 655
Cdd:pfam00439  81 AA 82
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 364-464 1.31e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 61.76  E-value: 1.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354  364 FSHQLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPSQ-GFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIK- 441
Cdd:pfam00583  12 FPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDEpPVGEIEGLAVAPEYRGKGIGTALLQALLEWAREr 91

                          90       100
                  ....*....|....*....|....*
gi 568999354  442 --HEILNFLTYADEYAIGYFKKQGF 464
Cdd:pfam00583  92 gcERIFLEVAADNLAAIALYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 388-444 4.16e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 41.88  E-value: 4.16e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568999354 388 LALIKDGRVIGGICFRMFPSQGFT-EIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHEI 444
Cdd:cd04301    2 LVAEDDGEIVGFASLSPDGSGGDTaYIGDLAVLPEYRGKGIGSALLEAAEEEARERGA 59
 
Name Accession Description Interval E-value
PCAF_N pfam06466
PCAF (P300/CBP-associated factor) N-terminal domain; This region is spliced out of Swiss: ...
 1-168 1.07e-101

PCAF (P300/CBP-associated factor) N-terminal domain; This region is spliced out of Swiss:Q92830 isoform 2. It is predicted to be of a mixed alpha/beta fold - though predominantly helical.


Pssm-ID: 461923  Cd Length: 249  Bit Score: 310.78  E-value: 1.07e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354    1 MDRLLGIVLDVEYLFTCVHKEEDADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKkPPFEKPSIEQGVNNFVQYKFSHLP 80
Cdd:pfam06466  83 LNRLLGMVVDVENLFMSVHKEEDADTKQVYFYLFKLLRKCILSMTKPVIEGPLGQ-PPFERPSIAKAVMNFVLYKFSHLP 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354   81 SKERQTTIELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPRYETTKVFGRTLLRSVFT 160
Cdd:pfam06466 162 QREWQTMYDLAKMFLHCLNHWNFETPSARKQRAKAEDASAYKINYTRWLCFCHVPAFCDSLPHYETTLVFGRTLLRAVFK 241


                  ....*...
gi 568999354  161 IMRRQLLE 168
Cdd:pfam06466 242 VVRRQLLD 249
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 569-668 4.49e-54

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 180.06  E-value: 4.49e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 569 QLYSTLKNILQQVKNHPNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPE 648
Cdd:cd05509    1 PLYTQLKKVLDSLKNHKSAWPFLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPD 80

                         90       100
                 ....*....|....*....|
gi 568999354 649 SEYYKCASILEKFFFSKIKE 668
Cdd:cd05509   81 TEYYKCANKLEKFFWKKLKE 100
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 329-668 5.22e-39

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 148.03  E-value: 5.22e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 329 LEERRGVIEFHVVGNSLNQKPNKKILMwlvGLQNVFSHQLPRMPKEYITRLVFDPKHKTLALI-KDGRVIGGICFRMF-- 405
Cdd:COG5076   17 LKEEFGNELLRLVDNDSSPFPNAPEEE---GSKNLFQKQLKRMPKEYITSIVDDREPGSMANVnDDLENVGGITYSPFek 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 406 ---PSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKH---EILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYI 479
Cdd:COG5076   94 nrpESLRFDEIVFLAIESVTPESGLGSLLMAHLKTSVKKRktpKIEDELLYADNKAIAKFKKQLFLRDGRFLSSIFLGLP 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 480 KDYEGATLMGCELNPqIPYTEFsviikkqkeiikklieRKQAQIRKvYPGLSCFKDGVRQI---------PIESIPGIRE 550
Cdd:COG5076  174 SKREYPDYYEIIKSP-MDLLTI----------------QKKLKNGR-YKSFEEFVSDLNLMfdncklyngPDSSVYVDAK 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 551 TGWKPSGKEKSKEPKDPEQLYSTLKN---------ILQQVKNHPNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRN 621
Cdd:COG5076  236 ELEKYFLKLIEEIPEEMLELSIKPGReereeresvLITNSQAHVGAWPFLRPVSDEEVPDYYKDIRDPMDLSTKELKLRN 315

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 568999354 622 RYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCASILEKFFFSKIKE 668
Cdd:COG5076  316 NYYRPEETFVRDAKLFFDNCVMYNGEVTDYYKNANVLEDFVIKKTRL 362
BROMO smart00297
bromo domain;
563-669 7.35e-38

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 136.25  E-value: 7.35e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354   563 EPKDPEQLYSTLKNILQQVKNHPNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCK 642
Cdd:smart00297   1 DPKLQKKLQELLKAVLDKLDSHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNAR 80

                           90       100
                   ....*....|....*....|....*..
gi 568999354   643 EYNPPESEYYKCASILEKFFFSKIKEA 669
Cdd:smart00297  81 TYNGPDSEVYKDAKKLEKFFEKKLREL 107
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 574-666 1.43e-29

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 112.47  E-value: 1.43e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 574 LKNILQQVKNH--PNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPESEY 651
Cdd:cd04369    5 LRSLLDALKKLkrDLSEPFLEPVDPKEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGPGSPI 84

                         90
                 ....*....|....*
gi 568999354 652 YKCASILEKFFFSKI 666
Cdd:cd04369   85 YKDAKKLEKLFEKLL 99
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 572-671 5.24e-28

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 108.64  E-value: 5.24e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 572 STLKNILQQVKNHPNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPESEY 651
Cdd:cd05504   15 SALEQLLVEIVKHKDSWPFLRPVSKIEVPDYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLVFSNCFLYNPEHTSV 94

                         90       100
                 ....*....|....*....|
gi 568999354 652 YKCASILEKFFFSKIKEAGL 671
Cdd:cd05504   95 YKAGTRLQRFFIKRCRKLGL 114
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 574-655 1.22e-24

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 97.77  E-value: 1.22e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354  574 LKNILQQVKNHPNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYK 653
Cdd:pfam00439   1 CLEILDKLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYK 80


                  ..
gi 568999354  654 CA 655
Cdd:pfam00439  81 AA 82
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 577-665 9.79e-24

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 95.90  E-value: 9.79e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 577 ILQQVKNHPNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCAS 656
Cdd:cd05503    8 ILDEMEAHEDAWPFLEPVNTKLVPGYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFNEDDSEVGRAGH 87


                 ....*....
gi 568999354 657 ILEKFFFSK 665
Cdd:cd05503   88 NMRKFFEKR 96
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 568-660 1.80e-23

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 95.59  E-value: 1.80e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 568 EQLYSTLKNILQQVKNH-PNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNP 646
Cdd:cd05510    6 EEFYESLDKVLNELKTYtEHSTPFLTKVSKREAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLYNS 85

                         90
                 ....*....|....*
gi 568999354 647 PESEYYK-CASILEK 660
Cdd:cd05510   86 DPSHPLRrHANFMKK 100
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 569-669 3.44e-23

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 94.80  E-value: 3.44e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 569 QLYSTLKNILQQVKNHPNAWPFMEPV--KRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNP 646
Cdd:cd05497    5 QLQYLLKVVLKALWKHKFAWPFQQPVdaVKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCYIYNK 84

                         90       100
                 ....*....|....*....|...
gi 568999354 647 PESEYYKCASILEKFFFSKIKEA 669
Cdd:cd05497   85 PGDDVVLMAQTLEKLFLQKLAQM 107
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 572-662 1.59e-21

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 89.65  E-value: 1.59e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 572 STLKNILQQvKNHPNAWPFMEPVK--RTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPES 649
Cdd:cd05499    7 EVLKELMKP-KHSAYNWPFLDPVDpvALNIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTFNPEGT 85

                         90
                 ....*....|...
gi 568999354 650 EYYKCASILEKFF 662
Cdd:cd05499   86 DVYMMGHQLEEVF 98
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 570-655 1.83e-20

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 86.93  E-value: 1.83e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 570 LYSTLKNILQQVKNHPNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPES 649
Cdd:cd05511    1 LSFILDEIVNELKNLPDSWPFHTPVNKKKVPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDS 80


                 ....*.
gi 568999354 650 EYYKCA 655
Cdd:cd05511   81 VYTKKA 86
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 572-662 1.09e-17

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 78.86  E-value: 1.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 572 STLKNILQQVKNHPNAWPFMEPV--KRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPES 649
Cdd:cd05498    6 SGILKELFSKKHKAYAWPFYKPVdpEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKYNPPDH 85

                         90
                 ....*....|...
gi 568999354 650 EYYKCASILEKFF 662
Cdd:cd05498   86 PVHAMARKLQDVF 98
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 589-669 8.97e-17

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 76.56  E-value: 8.97e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 589 PFMEPVKrTEAPGYYEVIRFPMDLKTMSERLRNR---YYVSKKLFMADLQRVFTNCKEYNPPESEYYKCASILEKFFFSK 665
Cdd:cd05502   24 PFHEPVS-PSVPNYYKIIKTPMDLSLIRKKLQPKspqHYSSPEEFVADVRLMFKNCYKFNEEDSEVAQAGKELELFFEEQ 102


                 ....
gi 568999354 666 IKEA 669
Cdd:cd05502  103 LKEI 106
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 576-662 9.22e-17

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 75.83  E-value: 9.22e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 576 NILQQVKNHPNAWPFMEPV--KRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYK 653
Cdd:cd05506    7 TLLRKLMKHKWGWVFNAPVdvVALGLPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRYNPPGNDVHT 86


                 ....*....
gi 568999354 654 CASILEKFF 662
Cdd:cd05506   87 MAKELLKIF 95
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 576-662 9.95e-16

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 73.12  E-value: 9.95e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 576 NILQQVKNHPNAWPFMEPVK--RTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYK 653
Cdd:cd05500   11 SSIRSLKRLKDARPFLVPVDpvKLNIPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLTFNGPEHPVSQ 90


                 ....*....
gi 568999354 654 CASILEKFF 662
Cdd:cd05500   91 MGKRLQAAF 99
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 577-662 1.59e-15

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 72.57  E-value: 1.59e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 577 ILQQVKNHPNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCAS 656
Cdd:cd05505    8 ILSKILKYRFSWPFREPVTADEAEDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKYYENGSYVLSCMR 87


                 ....*.
gi 568999354 657 ILEKFF 662
Cdd:cd05505   88 KTEQCC 93
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 569-660 3.97e-15

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 71.57  E-value: 3.97e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 569 QLYSTLKNILQQvKNHPNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPE 648
Cdd:cd05515    7 ELYNAVKNYTDG-RGRRLSLIFMRLPSKSEYPDYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNEPD 85

                         90
                 ....*....|..
gi 568999354 649 SEYYKCASILEK 660
Cdd:cd05515   86 SQIYKDALTLQK 97
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 590-665 5.61e-14

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 68.24  E-value: 5.61e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568999354 590 FMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCASILEKFFFSK 665
Cdd:cd05518   27 FMEKPSKKDYPDYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHYNEEGSQVYEDANILEKVLKEK 102
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 569-646 3.52e-13

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 66.23  E-value: 3.52e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568999354 569 QLYSTLKNILQQVKNHPNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNP 646
Cdd:cd05528    3 ELRLFLRDVLKRLASDKRFNAFTKPVDEEEVPDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALEYNP 80
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 574-659 1.63e-12

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 64.67  E-value: 1.63e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 574 LKNILQQV---KNHPNAWPFMEPVK-RTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPES 649
Cdd:cd05529   29 LISGLDKLllsLQLEIAEYFEYPVDlRAWYPDYWNRVPVPMDLETIRSRLENRYYRSLEALRHDVRLILSNAETFNEPNS 108

                         90
                 ....*....|
gi 568999354 650 EYYKCASILE 659
Cdd:cd05529  109 EIAKKAKRLS 118
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 569-665 3.08e-12

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 63.13  E-value: 3.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 569 QLYSTlknilqqVKNHPN------AWPFME-PVKRtEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNC 641
Cdd:cd05520    7 QLYDT-------IRNARNnqgqllAEPFLKlPSKR-KYPDYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENA 78

                         90       100
                 ....*....|....*....|....
gi 568999354 642 KEYNPPESEYYKCASILEKFFFSK 665
Cdd:cd05520   79 KRYNVPNSRIYKDAEKLQKLMQAK 102
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 574-655 5.93e-12

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 62.43  E-value: 5.93e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 574 LKNILQQV-KNHPNAWpFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPESEYY 652
Cdd:cd05513    6 LEQLIRQLqRKDPHGF-FAFPVTDFIAPGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYNKPDTIYY 84


                 ...
gi 568999354 653 KCA 655
Cdd:cd05513   85 KAA 87
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 570-655 1.14e-11

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 61.65  E-value: 1.14e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 570 LYSTLKNILQQVKNHPNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPES 649
Cdd:cd05512    2 LEVLLRKTLDQLQEKDTAEIFSEPVDLSEVPDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYNAKDT 81


                 ....*.
gi 568999354 650 EYYKCA 655
Cdd:cd05512   82 IFYRAA 87
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 364-464 1.31e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 61.76  E-value: 1.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354  364 FSHQLPRMPKEYITRLVFDPKHKTLALIKDGRVIGGICFRMFPSQ-GFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIK- 441
Cdd:pfam00583  12 FPEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDEpPVGEIEGLAVAPEYRGKGIGTALLQALLEWAREr 91

                          90       100
                  ....*....|....*....|....*
gi 568999354  442 --HEILNFLTYADEYAIGYFKKQGF 464
Cdd:pfam00583  92 gcERIFLEVAADNLAAIALYEKLGF 116
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 567-666 3.79e-11

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 60.15  E-value: 3.79e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 567 PEQLYSTLKNILQQV-KNHPNAWPFMEPV--KRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKE 643
Cdd:cd05495    1 PEELRQALMPTLEKLyKQDPESLPFRQPVdpKLLGIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWL 80

                         90       100
                 ....*....|....*....|...
gi 568999354 644 YNPPESEYYKCASILEKFFFSKI 666
Cdd:cd05495   81 YNRKTSRVYKYCTKLAEVFEQEI 103
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 575-662 1.43e-10

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 58.41  E-value: 1.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 575 KNILQQVK------NHPNAWPFME-PVKRTEaPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPP 647
Cdd:cd05522    7 KNILKGLRkerdenGRLLTLHFEKlPDKARE-PEYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAKLYNEN 85

                         90
                 ....*....|....*
gi 568999354 648 ESEYYKCASILEKFF 662
Cdd:cd05522   86 DSQEYKDAVLLEKEA 100
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 569-668 1.76e-10

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 58.50  E-value: 1.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 569 QLYSTLKNIlQQVKNHPNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPE 648
Cdd:cd05524    9 ELYDTIRNY-KSEDGRILCESFIRVPKRRNEPEYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAYYKPD 87

                         90       100
                 ....*....|....*....|
gi 568999354 649 SEYYKCASILEKFFFSKIKE 668
Cdd:cd05524   88 SPEHKDACKLWELFLSARNE 107
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 577-656 1.56e-09

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 55.45  E-value: 1.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 577 ILQQVKNHPNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCAS 656
Cdd:cd05507   11 VYRTLASHRYASVFLKPVTEDIAPGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSDHDVYLMAV 90
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 596-666 3.05e-09

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 54.64  E-value: 3.05e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568999354 596 RTEAPGYYEVIRFPMDLKTMSERLRNryYVSKKLFMADLQRVFTNCKEYNPPESEYYKCASILEKFFFSKI 666
Cdd:cd05521   34 RKDYPDYYKIIKNPLSLNTVKKRLPH--YTNAQEFVNDLAQIPWNARLYNTKGSVIYKYALILEKYINDVI 102
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 600-662 3.50e-09

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 54.75  E-value: 3.50e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568999354 600 PGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCASILEKFF 662
Cdd:cd05517   37 PDYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEPGSQVYKDANAIKKIF 99
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 569-662 8.09e-09

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 53.59  E-value: 8.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 569 QLYSTLKNILQQVKNHPN------AWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCK 642
Cdd:cd05516    1 ELTKKMNKIVDVVIKYKDsdgrqlAEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQNAQ 80

                         90       100
                 ....*....|....*....|
gi 568999354 643 EYNPPESEYYKCASILEKFF 662
Cdd:cd05516   81 TFNLEGSLIYEDSIVLQSVF 100
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 590-666 1.12e-08

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 53.11  E-value: 1.12e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568999354 590 FMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCASILEKFFFSKI 666
Cdd:cd05519   27 FLEKPSKKLYPDYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTYNQEGSIVYEDAVEMEKAFKKKY 103
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 589-667 1.30e-08

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 53.62  E-value: 1.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 589 PFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNP-PESEYYKCASILEKFFFSKIK 667
Cdd:cd05496   25 PFRQPVDLLKYPDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSYTPnKRSRIYSMTLRLSALFEEHIK 104
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 568-660 1.66e-08

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 52.39  E-value: 1.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 568 EQLYSTLKNILQQVKnHPNAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPP 647
Cdd:cd05508    2 DQLSKLLKFALERMK-QPGAEPFLKPVDLEQFPDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAIIYNGG 80

                         90
                 ....*....|...
gi 568999354 648 ESEYYKCASILEK 660
Cdd:cd05508   81 DHKLTQAAKAIVK 93
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 383-464 2.19e-08

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 51.69  E-value: 2.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354  383 PKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHEILNFLTYADEYAIGYFKKQ 462
Cdd:pfam13508   1 PGGRFFVAEDDGKIVGFAALLPLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRAAAFYEKL 80


                  ..
gi 568999354  463 GF 464
Cdd:pfam13508  81 GF 82
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 589-664 1.90e-05

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 43.92  E-value: 1.90e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568999354 589 PFMEPVKRTEAPGYYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCASILEKFFFS 664
Cdd:cd05525   28 PFINLPSKKKNPDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYYGRKSPIGRDVCRLRKAYYQ 103
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 388-444 4.16e-05

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 41.88  E-value: 4.16e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568999354 388 LALIKDGRVIGGICFRMFPSQGFT-EIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHEI 444
Cdd:cd04301    2 LVAEDDGEIVGFASLSPDGSGGDTaYIGDLAVLPEYRGKGIGSALLEAAEEEARERGA 59
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 382-464 5.23e-05

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 43.44  E-value: 5.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 382 DPKHKTLALIKDGRVIGGICFRMFPsQGFTEIVFCAVTSNEQVKGYGTHLMNHL----KEYHIKHeiLNFLTYADeyAIG 457
Cdd:COG1246   25 EEIGEFWVAEEDGEIVGCAALHPLD-EDLAELRSLAVHPDYRGRGIGRRLLEALlaeaRELGLKR--LFLLTTSA--AIH 99


                 ....*..
gi 568999354 458 YFKKQGF 464
Cdd:COG1246  100 FYEKLGF 106
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 602-668 1.98e-04

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 40.87  E-value: 1.98e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568999354 602 YYEVIRFPMDLKTMSERLRNRYYVSKKLFMADLQRVFTNCKEYNpPESEYYKCASILEKFFFSKIKE 668
Cdd:cd05501   33 YCQGIKEPMWLNKVKERLNERVYHTVEGFVRDMRLIFHNHKLFY-KDDDFGQVGITLEKKFEKNFKE 98
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 578-619 4.41e-04

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 40.50  E-value: 4.41e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 568999354 578 LQQVKNHPNAWPFMEPV--KRTEAPGYYEVIRFPMDLKTMSERL 619
Cdd:cd05494   12 LKRHRRNEDAWPFLEPVnpPRRGAPDYRDVIKRPMSFGTKVNNI 55
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
387-464 1.48e-03

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 39.30  E-value: 1.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568999354 387 TLALIKDGRVIGGICFRMFPSQGFTEIVF---CAVTSNEQVKGYGTHLMNHLKEYHIKHEILNFLTYADEYAIGYFKKQG 463
Cdd:COG3153   41 SLVAEDDGEIVGHVALSPVDIDGEGPALLlgpLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDPSLLPFYERFG 120


                 .
gi 568999354 464 F 464
Cdd:COG3153  121 F 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH