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Conserved domains on  [gi|568991287|ref|XP_006520469|]
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desert hedgehog protein isoform X1 [Mus musculus]

Protein Classification

HH_signal and Hint domain-containing protein( domain architecture ID 11645567)

HH_signal and Hint domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hint pfam01079
Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not ...
 73-280 5.66e-102

Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module.


:

Pssm-ID: 460051 [Multi-domain]  Cd Length: 212  Bit Score: 296.47  E-value: 5.66e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991287   73 KADNSLAVRAGGCFPGNATVRLRSGERKGLRELHRGDWVLAADAAGRVVPTPVLLFLDRDLQRRASFVAVETERPpRKLL 152
Cdd:pfam01079   1 KAEHSVAAKTGGCFPGDATVTLEDGGRKPMSELQPGDRVLAMDGGGQVVYSPVLMFLDRDPEQRAEFVEIETDNG-ETLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991287  153 LTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAP--GGDALQPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCY 230
Cdd:pfam01079  80 LTPAHLVFVADCERSSSALERAVFASRVRPGDCVLVPdtGGGELRPVRVVSVSTVEATGVYAPLTSHGTIVVNRVLASCY 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568991287  231 AVLESHQWAHRAFAPLRLLHALGALL-PGGAVQPTGMHWYSRLLYRLAEEL 280
Cdd:pfam01079 160 AVIDSHSLAHWAFAPVRLLHSLSSLFwPNAASQTEGIHWYSNLLYGLGSLL 210
HH_signal super family cl03090
Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. ...
 1-71 1.79e-52

Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.


The actual alignment was detected with superfamily member pfam01085:

Pssm-ID: 460055  Cd Length: 161  Bit Score: 168.71  E-value: 1.79e-52
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568991287    1 MNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHIHVS 71
Cdd:pfam01085  91 MNQWPGVKLRVTEAWDEDGHHPPDSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESRAHIHCS 161
 
Name Accession Description Interval E-value
Hint pfam01079
Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not ...
 73-280 5.66e-102

Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module.


Pssm-ID: 460051 [Multi-domain]  Cd Length: 212  Bit Score: 296.47  E-value: 5.66e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991287   73 KADNSLAVRAGGCFPGNATVRLRSGERKGLRELHRGDWVLAADAAGRVVPTPVLLFLDRDLQRRASFVAVETERPpRKLL 152
Cdd:pfam01079   1 KAEHSVAAKTGGCFPGDATVTLEDGGRKPMSELQPGDRVLAMDGGGQVVYSPVLMFLDRDPEQRAEFVEIETDNG-ETLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991287  153 LTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAP--GGDALQPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCY 230
Cdd:pfam01079  80 LTPAHLVFVADCERSSSALERAVFASRVRPGDCVLVPdtGGGELRPVRVVSVSTVEATGVYAPLTSHGTIVVNRVLASCY 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568991287  231 AVLESHQWAHRAFAPLRLLHALGALL-PGGAVQPTGMHWYSRLLYRLAEEL 280
Cdd:pfam01079 160 AVIDSHSLAHWAFAPVRLLHSLSSLFwPNAASQTEGIHWYSNLLYGLGSLL 210
HH_signal pfam01085
Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. ...
 1-71 1.79e-52

Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.


Pssm-ID: 460055  Cd Length: 161  Bit Score: 168.71  E-value: 1.79e-52
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568991287    1 MNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHIHVS 71
Cdd:pfam01085  91 MNQWPGVKLRVTEAWDEDGHHPPDSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESRAHIHCS 161
Hint cd00081
Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins ...
 85-229 7.53e-32

Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, and the flanking polypeptide sequences - the exteins - are joined by a peptide bond. In addition to the autocatalytic splicing domain, many inteins contain an inserted endonuclease domain, which plays a role in spreading inteins. Hedgehog proteins are a major class of intercellular signaling molecules, which control inductive interactions during animal development. The mature signaling forms of hedgehog proteins are the N-terminal fragments, which are covalently linked to cholesterol at their C-termini. This modification is the result of an autoprocessing step catalyzed by the C-terminal fragments, which are aligned here.


Pssm-ID: 238035 [Multi-domain]  Cd Length: 136  Bit Score: 114.67  E-value: 7.53e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991287  85 CFPGNATVRLRSGERKGLRELHR--GDWVLAADAAGRVVPTPVLLFLDRDlqRRASFVAVETERpPRKLLLTPWHLVFAA 162
Cdd:cd00081    1 CFTGDTLVLLEDGGRKKIEELVEkkGDKVLALDETGKLVFSKVLKVLRRD--YEKKFYKIKTES-GREITLTPDHLLFVL 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568991287 163 RGpapapGDFAPVFARRLRAGDSVLAPggdalQPARVARVAREEAV-GVFAPLTA-HGTLLVNDVLASC 229
Cdd:cd00081   78 ED-----GELKWVFASDLKPGDYVLVP-----VLEKVKEIEEIEYTgGVYDLTVEdNHNFIANGVLVHN 136
HintN smart00306
Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. ...
 84-189 1.47e-23

Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. Domain has been split to accommodate large insertions of endonucleases.


Pssm-ID: 197642 [Multi-domain]  Cd Length: 100  Bit Score: 91.95  E-value: 1.47e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991287    84 GCFPGNATVRLRSGERKGLRELHRGDWVLAADaAGRVVPTPVLLFLDRDLQRRASFVAVETERpPRKLLLTPWHLVFAAR 163
Cdd:smart00306   1 GCFPGDTLVLTEDGGIKKIEELEEGDKVLALD-EGTLKYSPVKVFLVREPKGEKKFYRIKTEN-GREITLTPDHLLLVRD 78

                           90       100
                   ....*....|....*....|....*.
gi 568991287   164 GpapapGDFAPVFARRLRAGDSVLAP 189
Cdd:smart00306  79 G-----GKLVWVFASELKPGDYVLVP 99
YcbK COG3108
Uncharacterized conserved protein YcbK, DUF882 family [Function unknown];
22-72 3.31e-03

Uncharacterized conserved protein YcbK, DUF882 family [Function unknown];


Pssm-ID: 442342  Cd Length: 138  Bit Score: 37.20  E-value: 3.31e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568991287  22 AQDSLHYEGRALDITTSDRDRNKyglLARLAVEAGFDWV-YYESRNHIHVSV 72
Cdd:COG3108   82 AKNSLHMLGKAADIRIPGVSLSQ---LRRAALALGRGGVgYYPRSGFVHVDT 130
intein_Nterm TIGR01445
intein N-terminal splicing region; This model is based on interated search results, starting ...
 86-160 9.20e-03

intein N-terminal splicing region; This model is based on interated search results, starting with a curated collection of intein N-terminal splicing regions from InBase, the New England Biolabs Intein Database, as presented on its web site. It is designed to recognize inteins but not the related region of the sonic hedgehog protein.


Pssm-ID: 273629 [Multi-domain]  Cd Length: 81  Bit Score: 34.60  E-value: 9.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991287   86 FPGNATVRLRSGERKGLREL---------HRGDWVLAADAAGRVVPTPVLLFLDRdlqRRASFVAVETERPpRKLLLTPW 156
Cdd:TIGR01445   1 LTGDTKVLTEDGETVKIGELvekekdekePIKVKVLSLDGGKIVKARPVVVWKRR---AEGKLIRIKTENG-REIKATPD 76


                  ....
gi 568991287  157 HLVF 160
Cdd:TIGR01445  77 HPFL 80
 
Name Accession Description Interval E-value
Hint pfam01079
Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not ...
 73-280 5.66e-102

Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module.


Pssm-ID: 460051 [Multi-domain]  Cd Length: 212  Bit Score: 296.47  E-value: 5.66e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991287   73 KADNSLAVRAGGCFPGNATVRLRSGERKGLRELHRGDWVLAADAAGRVVPTPVLLFLDRDLQRRASFVAVETERPpRKLL 152
Cdd:pfam01079   1 KAEHSVAAKTGGCFPGDATVTLEDGGRKPMSELQPGDRVLAMDGGGQVVYSPVLMFLDRDPEQRAEFVEIETDNG-ETLT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991287  153 LTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAP--GGDALQPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCY 230
Cdd:pfam01079  80 LTPAHLVFVADCERSSSALERAVFASRVRPGDCVLVPdtGGGELRPVRVVSVSTVEATGVYAPLTSHGTIVVNRVLASCY 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568991287  231 AVLESHQWAHRAFAPLRLLHALGALL-PGGAVQPTGMHWYSRLLYRLAEEL 280
Cdd:pfam01079 160 AVIDSHSLAHWAFAPVRLLHSLSSLFwPNAASQTEGIHWYSNLLYGLGSLL 210
HH_signal pfam01085
Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. ...
 1-71 1.79e-52

Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.


Pssm-ID: 460055  Cd Length: 161  Bit Score: 168.71  E-value: 1.79e-52
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568991287    1 MNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHIHVS 71
Cdd:pfam01085  91 MNQWPGVKLRVTEAWDEDGHHPPDSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESRAHIHCS 161
Hint cd00081
Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins ...
 85-229 7.53e-32

Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, and the flanking polypeptide sequences - the exteins - are joined by a peptide bond. In addition to the autocatalytic splicing domain, many inteins contain an inserted endonuclease domain, which plays a role in spreading inteins. Hedgehog proteins are a major class of intercellular signaling molecules, which control inductive interactions during animal development. The mature signaling forms of hedgehog proteins are the N-terminal fragments, which are covalently linked to cholesterol at their C-termini. This modification is the result of an autoprocessing step catalyzed by the C-terminal fragments, which are aligned here.


Pssm-ID: 238035 [Multi-domain]  Cd Length: 136  Bit Score: 114.67  E-value: 7.53e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991287  85 CFPGNATVRLRSGERKGLRELHR--GDWVLAADAAGRVVPTPVLLFLDRDlqRRASFVAVETERpPRKLLLTPWHLVFAA 162
Cdd:cd00081    1 CFTGDTLVLLEDGGRKKIEELVEkkGDKVLALDETGKLVFSKVLKVLRRD--YEKKFYKIKTES-GREITLTPDHLLFVL 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568991287 163 RGpapapGDFAPVFARRLRAGDSVLAPggdalQPARVARVAREEAV-GVFAPLTA-HGTLLVNDVLASC 229
Cdd:cd00081   78 ED-----GELKWVFASDLKPGDYVLVP-----VLEKVKEIEEIEYTgGVYDLTVEdNHNFIANGVLVHN 136
HintN smart00306
Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. ...
 84-189 1.47e-23

Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. Domain has been split to accommodate large insertions of endonucleases.


Pssm-ID: 197642 [Multi-domain]  Cd Length: 100  Bit Score: 91.95  E-value: 1.47e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991287    84 GCFPGNATVRLRSGERKGLRELHRGDWVLAADaAGRVVPTPVLLFLDRDLQRRASFVAVETERpPRKLLLTPWHLVFAAR 163
Cdd:smart00306   1 GCFPGDTLVLTEDGGIKKIEELEEGDKVLALD-EGTLKYSPVKVFLVREPKGEKKFYRIKTEN-GREITLTPDHLLLVRD 78

                           90       100
                   ....*....|....*....|....*.
gi 568991287   164 GpapapGDFAPVFARRLRAGDSVLAP 189
Cdd:smart00306  79 G-----GKLVWVFASELKPGDYVLVP 99
HintC smart00305
Hint (Hedgehog/Intein) domain C-terminal region; Hedgehog/Intein domain, C-terminal region. ...
 194-235 3.87e-08

Hint (Hedgehog/Intein) domain C-terminal region; Hedgehog/Intein domain, C-terminal region. Domain has been split to accommodate large insertions of endonucleases.


Pssm-ID: 197641  Cd Length: 46  Bit Score: 48.71  E-value: 3.87e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 568991287   194 LQPARVARVAREEAVGVFAP-LTAHGTLLVNDVLASCYAVLES 235
Cdd:smart00305   4 FRFVRVKSIEETEYTGVYDPtVTENHNFIANGILVHNCAEIET 46
Vint pfam14623
Hint-domain; This short domain is a conserved region of intein-containing proteins from lower ...
 84-157 9.41e-04

Hint-domain; This short domain is a conserved region of intein-containing proteins from lower eukaryotes.


Pssm-ID: 434076  Cd Length: 166  Bit Score: 39.12  E-value: 9.41e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568991287   84 GCFPGNATVRLRSGERKGLRELHRGDWVLAADAAGRV---VPTPVllfldrdlqRRASFVAVEterpprKLLLTPWH 157
Cdd:pfam14623   1 PCFAGDSLVRLASGRTVPIRELRKGDKVQTPLGPRKVaavLKTPV---------ENEELCRIG------GLLITPWH 62
YcbK COG3108
Uncharacterized conserved protein YcbK, DUF882 family [Function unknown];
22-72 3.31e-03

Uncharacterized conserved protein YcbK, DUF882 family [Function unknown];


Pssm-ID: 442342  Cd Length: 138  Bit Score: 37.20  E-value: 3.31e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568991287  22 AQDSLHYEGRALDITTSDRDRNKyglLARLAVEAGFDWV-YYESRNHIHVSV 72
Cdd:COG3108   82 AKNSLHMLGKAADIRIPGVSLSQ---LRRAALALGRGGVgYYPRSGFVHVDT 130
intein_Nterm TIGR01445
intein N-terminal splicing region; This model is based on interated search results, starting ...
 86-160 9.20e-03

intein N-terminal splicing region; This model is based on interated search results, starting with a curated collection of intein N-terminal splicing regions from InBase, the New England Biolabs Intein Database, as presented on its web site. It is designed to recognize inteins but not the related region of the sonic hedgehog protein.


Pssm-ID: 273629 [Multi-domain]  Cd Length: 81  Bit Score: 34.60  E-value: 9.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568991287   86 FPGNATVRLRSGERKGLREL---------HRGDWVLAADAAGRVVPTPVLLFLDRdlqRRASFVAVETERPpRKLLLTPW 156
Cdd:TIGR01445   1 LTGDTKVLTEDGETVKIGELvekekdekePIKVKVLSLDGGKIVKARPVVVWKRR---AEGKLIRIKTENG-REIKATPD 76


                  ....
gi 568991287  157 HLVF 160
Cdd:TIGR01445  77 HPFL 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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