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Conserved domains on  [gi|568988389|ref|XP_006519421|]
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low-density lipoprotein receptor-related protein 10 isoform X1 [Mus musculus]

Protein Classification

CUB domain-containing protein( domain architecture ID 10059862)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 16-50 5.70e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.30  E-value: 5.70e-12
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 568988389  16 CLQEEFQCLNHRCIPAAQRCDGIDACGDGSDEAGC 50
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 275-309 1.01e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 1.01e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 568988389 275 CQPGNFRCRDEKCVYETWVCDGQPDCTDGSDEWDC 309
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 68-178 1.11e-11

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 61.66  E-value: 1.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988389  68 CNLTL-EDFYGVFSSPGYSHlaSVSHPQSCLWLLDPHDGRRLAVRFTALDLSYG-----DAVHVYDGagPPETPRLLRSL 141
Cdd:cd00041    1 CGGTLtASTSGTISSPNYPN--NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDG--PSTSSPLLGRF 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568988389 142 THFSNGKavTVETLSGQAVVSYHTVAWSSGRGFNATY 178
Cdd:cd00041   77 CGSTLPP--PIISSGNSLTVRFRSDSSVTGRGFKATY 111
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 206-229 1.50e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 39.11  E-value: 1.50e-04
                         10        20
                 ....*....|....*....|....
gi 568988389 206 RCYSEAQRCDGSWDCADGTDEEGC 229
Cdd:cd00112   12 RCIPSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 16-50 5.70e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.30  E-value: 5.70e-12
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 568988389  16 CLQEEFQCLNHRCIPAAQRCDGIDACGDGSDEAGC 50
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 275-309 1.01e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 1.01e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 568988389 275 CQPGNFRCRDEKCVYETWVCDGQPDCTDGSDEWDC 309
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 68-178 1.11e-11

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 61.66  E-value: 1.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988389  68 CNLTL-EDFYGVFSSPGYSHlaSVSHPQSCLWLLDPHDGRRLAVRFTALDLSYG-----DAVHVYDGagPPETPRLLRSL 141
Cdd:cd00041    1 CGGTLtASTSGTISSPNYPN--NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDG--PSTSSPLLGRF 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568988389 142 THFSNGKavTVETLSGQAVVSYHTVAWSSGRGFNATY 178
Cdd:cd00041   77 CGSTLPP--PIISSGNSLTVRFRSDSSVTGRGFKATY 111
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 16-47 3.24e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 3.24e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568988389    16 CLQEEFQCLNHRCIPAAQRCDGIDACGDGSDE 47
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 275-306 5.60e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 5.60e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568988389   275 CQPGNFRCRDEKCVYETWVCDGQPDCTDGSDE 306
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
275-309 1.38e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.41  E-value: 1.38e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568988389  275 CQPGNFRCRDEKCVYETWVCDGQPDCTDGSDEWDC 309
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
16-50 4.46e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.17  E-value: 4.46e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568988389   16 CLQEEFQCLNHRCIPAAQRCDGIDACGDGSDEAGC 50
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 77-178 2.51e-07

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 48.93  E-value: 2.51e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988389    77 GVFSSPGYShlASVSHPQSCLWLLDPHDGRRLAVRFTALDLSYG-----DAVHVYDGAGppetpRLLRSLTHF--SNGKA 149
Cdd:smart00042   1 GTITSPNYP--QSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSdnceyDYVEIYDGPS-----ASSPLLGRFcgSEAPP 73

                           90       100
                   ....*....|....*....|....*....
gi 568988389   150 VTVETLSGQAVVSYHTVAWSSGRGFNATY 178
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
68-178 1.18e-06

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 47.29  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988389   68 CNLTLEDFYGVFSSPGYSHlasvSHPQS--CLWLLDPHDGRRLAVRFTALDLS-----YGDAVHVYDGagPPETPRLLRS 140
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPN----PYPPNkdCVWLIRAPPGFRVKLTFQDFELEdhdecGYDYVEIRDG--PSASSPLLGR 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 568988389  141 LTHFsnGKAVTVETLSGQAVVSYHTVAWSSGRGFNATY 178
Cdd:pfam00431  75 FCGS--GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 206-229 1.50e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 39.11  E-value: 1.50e-04
                         10        20
                 ....*....|....*....|....
gi 568988389 206 RCYSEAQRCDGSWDCADGTDEEGC 229
Cdd:cd00112   12 RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 206-226 2.50e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 35.69  E-value: 2.50e-03
                           10        20
                   ....*....|....*....|.
gi 568988389   206 RCYSEAQRCDGSWDCADGTDE 226
Cdd:smart00192  13 RCIPSSWVCDGVDDCGDGSDE 33
 
Name Accession Description Interval E-value
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 16-50 5.70e-12

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.30  E-value: 5.70e-12
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 568988389  16 CLQEEFQCLNHRCIPAAQRCDGIDACGDGSDEAGC 50
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 275-309 1.01e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 1.01e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 568988389 275 CQPGNFRCRDEKCVYETWVCDGQPDCTDGSDEWDC 309
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 68-178 1.11e-11

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 61.66  E-value: 1.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988389  68 CNLTL-EDFYGVFSSPGYSHlaSVSHPQSCLWLLDPHDGRRLAVRFTALDLSYG-----DAVHVYDGagPPETPRLLRSL 141
Cdd:cd00041    1 CGGTLtASTSGTISSPNYPN--NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSpncsyDYLEIYDG--PSTSSPLLGRF 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 568988389 142 THFSNGKavTVETLSGQAVVSYHTVAWSSGRGFNATY 178
Cdd:cd00041   77 CGSTLPP--PIISSGNSLTVRFRSDSSVTGRGFKATY 111
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 16-47 3.24e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 55.33  E-value: 3.24e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568988389    16 CLQEEFQCLNHRCIPAAQRCDGIDACGDGSDE 47
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 275-306 5.60e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.56  E-value: 5.60e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568988389   275 CQPGNFRCRDEKCVYETWVCDGQPDCTDGSDE 306
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
275-309 1.38e-09

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 53.41  E-value: 1.38e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568988389  275 CQPGNFRCRDEKCVYETWVCDGQPDCTDGSDEWDC 309
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
16-50 4.46e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 49.17  E-value: 4.46e-08
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568988389   16 CLQEEFQCLNHRCIPAAQRCDGIDACGDGSDEAGC 50
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 77-178 2.51e-07

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 48.93  E-value: 2.51e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988389    77 GVFSSPGYShlASVSHPQSCLWLLDPHDGRRLAVRFTALDLSYG-----DAVHVYDGAGppetpRLLRSLTHF--SNGKA 149
Cdd:smart00042   1 GTITSPNYP--QSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSdnceyDYVEIYDGPS-----ASSPLLGRFcgSEAPP 73

                           90       100
                   ....*....|....*....|....*....
gi 568988389   150 VTVETLSGQAVVSYHTVAWSSGRGFNATY 178
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
68-178 1.18e-06

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 47.29  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568988389   68 CNLTLEDFYGVFSSPGYSHlasvSHPQS--CLWLLDPHDGRRLAVRFTALDLS-----YGDAVHVYDGagPPETPRLLRS 140
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPN----PYPPNkdCVWLIRAPPGFRVKLTFQDFELEdhdecGYDYVEIRDG--PSASSPLLGR 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 568988389  141 LTHFsnGKAVTVETLSGQAVVSYHTVAWSSGRGFNATY 178
Cdd:pfam00431  75 FCGS--GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 206-229 1.50e-04

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 39.11  E-value: 1.50e-04
                         10        20
                 ....*....|....*....|....
gi 568988389 206 RCYSEAQRCDGSWDCADGTDEEGC 229
Cdd:cd00112   12 RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 206-226 2.50e-03

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 35.69  E-value: 2.50e-03
                           10        20
                   ....*....|....*....|.
gi 568988389   206 RCYSEAQRCDGSWDCADGTDE 226
Cdd:smart00192  13 RCIPSSWVCDGVDDCGDGSDE 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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