3-oxo-5-alpha-steroid 4-dehydrogenase 1 isoform X1 [Mus musculus]
phosphatidylethanolamine N-methyltransferase family domain-containing protein( domain architecture ID 229533)
phosphatidylethanolamine N-methyltransferase (PEMT) family domain-containing protein similar to Homo sapiens PEMT, which catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC)
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
Steroid_dh super family | cl47745 | 3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ... |
106-183 | 1.09e-32 | ||||
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development. The actual alignment was detected with superfamily member pfam02544: Pssm-ID: 460585 [Multi-domain] Cd Length: 150 Bit Score: 115.19 E-value: 1.09e-32
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ICMT super family | cl21511 | Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine ... |
18-183 | 3.54e-19 | ||||
Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology. The actual alignment was detected with superfamily member PLN02392: Pssm-ID: 473892 Cd Length: 260 Bit Score: 82.94 E-value: 3.54e-19
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Name | Accession | Description | Interval | E-value | ||||
Steroid_dh | pfam02544 | 3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ... |
106-183 | 1.09e-32 | ||||
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development. Pssm-ID: 460585 [Multi-domain] Cd Length: 150 Bit Score: 115.19 E-value: 1.09e-32
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PLN02392 | PLN02392 | probable steroid reductase DET2 |
18-183 | 3.54e-19 | ||||
probable steroid reductase DET2 Pssm-ID: 178015 Cd Length: 260 Bit Score: 82.94 E-value: 3.54e-19
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PLN02560 | PLN02560 | enoyl-CoA reductase |
123-183 | 4.86e-05 | ||||
enoyl-CoA reductase Pssm-ID: 178174 [Multi-domain] Cd Length: 308 Bit Score: 43.17 E-value: 4.86e-05
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Name | Accession | Description | Interval | E-value | ||||
Steroid_dh | pfam02544 | 3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ... |
106-183 | 1.09e-32 | ||||
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development. Pssm-ID: 460585 [Multi-domain] Cd Length: 150 Bit Score: 115.19 E-value: 1.09e-32
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PLN02392 | PLN02392 | probable steroid reductase DET2 |
18-183 | 3.54e-19 | ||||
probable steroid reductase DET2 Pssm-ID: 178015 Cd Length: 260 Bit Score: 82.94 E-value: 3.54e-19
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PLN02560 | PLN02560 | enoyl-CoA reductase |
123-183 | 4.86e-05 | ||||
enoyl-CoA reductase Pssm-ID: 178174 [Multi-domain] Cd Length: 308 Bit Score: 43.17 E-value: 4.86e-05
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Blast search parameters | ||||
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