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Conserved domains on  [gi|568982491|ref|XP_006516983|]
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lysine-specific histone demethylase 1B isoform X7 [Mus musculus]

Protein Classification

lysine-specific histone demethylase 1B( domain architecture ID 13726372)

lysine-specific histone demethylase 1B (KDM1B) demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor

EC:  1.14.99.66
Gene Symbol:  KDM1B
Gene Ontology:  GO:0008270|GO:0050660|GO:0032452|GO:0042393
PubMed:  23266887|23260659

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02328 super family cl33466
lysine-specific histone demethylase 1 homolog
 308-724 2.64e-60

lysine-specific histone demethylase 1 homolog


The actual alignment was detected with superfamily member PLN02328:

Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 217.55  E-value: 2.64e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 308 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LTVAAGQHLLPKHY 386
Cdd:PLN02328 163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 387 HNKSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVwddKSFK----GVVVGR--GPQIVNGCINNPVALMCEQ- 459
Cdd:PLN02328 237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV---KTMKmkgdGVVAAAdlGGSVLTGINGNPLGVLARQl 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491     --------------------------------------------------------------------------------
Cdd:PLN02328 314 glplhkvrdicplylpdgkavdaeidskieasfnklldrvcklrqamieevksvdvnlgtaleafrhvykvaedpqerml 393

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 460 ------------------VSARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTdG 521
Cdd:PLN02328 394 lnwhlanleyanaslmsnLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVYAG-G 471

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 522 MGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQRGLFA 601
Cdd:PLN02328 472 QEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMRGEFF 548

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 602 VFYDMDS-QQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEI--PEPTKYFVTRWSTEPWIQMAYSFVKTF 678
Cdd:PLN02328 549 LFYSYSSvSGGPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFHPKGIvvPDPVQAVCTRWGKDCFTYGSYSYVAVG 628

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 568982491 679 GSGEAYDIIAEEI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 724
Cdd:PLN02328 629 SSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-191 1.00e-08

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


:

Pssm-ID: 462181  Cd Length: 46  Bit Score: 51.54  E-value: 1.00e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568982491  138 YWVQCTKpeCGKWRQLTKEIQlTPHMARTYRCGMKPNtitkpdtPDH--CSFPEDL 191
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPD-------PKYnsCDAPEEI 46
 
Name Accession Description Interval E-value
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 308-724 2.64e-60

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 217.55  E-value: 2.64e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 308 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LTVAAGQHLLPKHY 386
Cdd:PLN02328 163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 387 HNKSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVwddKSFK----GVVVGR--GPQIVNGCINNPVALMCEQ- 459
Cdd:PLN02328 237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV---KTMKmkgdGVVAAAdlGGSVLTGINGNPLGVLARQl 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491     --------------------------------------------------------------------------------
Cdd:PLN02328 314 glplhkvrdicplylpdgkavdaeidskieasfnklldrvcklrqamieevksvdvnlgtaleafrhvykvaedpqerml 393

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 460 ------------------VSARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTdG 521
Cdd:PLN02328 394 lnwhlanleyanaslmsnLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVYAG-G 471

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 522 MGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQRGLFA 601
Cdd:PLN02328 472 QEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMRGEFF 548

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 602 VFYDMDS-QQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEI--PEPTKYFVTRWSTEPWIQMAYSFVKTF 678
Cdd:PLN02328 549 LFYSYSSvSGGPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFHPKGIvvPDPVQAVCTRWGKDCFTYGSYSYVAVG 628

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 568982491 679 GSGEAYDIIAEEI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 724
Cdd:PLN02328 629 SSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
405-726 4.15e-59

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 206.31  E-value: 4.15e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 405 RQLHNFGMKVTVLEAKDRIGGRVW-DDKSFKGVVVGRGPQ---------------------------------------- 443
Cdd:COG1231   24 RELRKAGLDVTVLEARDRVGGRVWtLRFGDDGLYAELGAMrippshtnllalarelglplepfpnengnallylggkrvr 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 444 --------------------------------------------------------IVNGCINNPVALMCEQVSARSWDH 467
Cdd:COG1231  104 ageiaadlrgvaellakllralaaaldpwahpaaeldreslaewlrrngaspsarrLLGLLGAGEYGADPDELSLLDLLR 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 468 NEFFAQFAGDHTLLTPGYSTIIEKLAEGL--DIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRgaIQF 545
Cdd:COG1231  184 YAASAGGGAQQFRIVGGMDQLPRALAAELgdRIRLGAPVTRIRQDGDGVTVTTDDGGTVRADAVIVTVPPSVLRR--IEF 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 546 NPPLSEKKMKAINSLGAGIIEKIALQFPYRFW--DSKVQGADFfghvppsaSQRGLFAVFYDMDSQQQS--VLMSVITGE 621
Cdd:COG1231  262 DPPLPAAKRAAIQRLPYGAAIKVFLQFDRPFWeeDGLYGGISL--------TDLPIRQTWYPSNGPDGGagVLLGYVGGD 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 622 AVASLRTMDDKQVLQQCMGILRELFKEqEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAeEIQGTVFFAGEA 701
Cdd:COG1231  334 DARALAALSPEERVAAALEQLARIFGV-YAAEPVDYVSTDWGRDPWSRGAYAAAPPGQLTAAGPALA-EPDGRIHFAGEH 411

                        410       420
                 ....*....|....*....|....*
gi 568982491 702 TNRHFPQTVTGAYLSGVREASKIAA 726
Cdd:COG1231  412 TSDEWPGWVEGALESGERAAAEILA 436
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 405-724 4.18e-56

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 198.10  E-value: 4.18e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491  405 RQLHNFGMKVTVLEAKDRIGGRVWDDKsFKGVVVGRGPQIVNGCiNNPVALMCEQVSARS-------------------- 464
Cdd:pfam01593   8 RELLRAGHDVTVLEARDRVGGRIRTVR-DDGFLIELGAMWFHGA-QPPLLALLKELGLEDrlvlpdpapfytvlfaggrr 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491      --------------------------------------------------------------------------------
Cdd:pfam01593  86 ypgdfrrvpagwegllefgrllsipeklrlglaalasdaldefdlddfslaesllflgrrgpgdvevwdrlidpelfaal 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491  465 -------------------WDHNEFFAQFAGDHTLLTPGYSTIIEKLAE---GLDIRLKSPVQSIDYTGDEVQVTTTDGM 522
Cdd:pfam01593 166 pfasgafagdpselsaglaLPLLWALLGEGGSLLLPRGGLGALPDALAAqllGGDVRLNTRVRSIDREGDGVTVTLTDGE 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491  523 GHSAQKVLVTVPLAILQRgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKvqgaDFFGHVPPSASQRGLFAV 602
Cdd:pfam01593 246 VIEADAVIVTVPLGVLKR--ILFTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWPDL----GLLGLLSELLTGLGTAFS 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491  603 FYDMDSQ----QQSVLMSVIT-GEAVASLRTMDDKQVLQQCMGILRELFKEqEIPEPTKYFVTRWSTEPWIQMAYSFVKT 677
Cdd:pfam01593 320 WLTFPNRappgKGLLLLVYVGpGDRARELEGLSDEELLQAVLRDLRKLFGE-EAPEPLRVLVSDWHTDPWPRGSYSLPQY 398

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 568982491  678 FGSGEAYDIIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 724
Cdd:pfam01593 399 GPGHDDYRPLARTPDPGLFFAGEHTSTGYPGTVEGAIESGRRAARAV 445
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-191 1.00e-08

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 51.54  E-value: 1.00e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568982491  138 YWVQCTKpeCGKWRQLTKEIQlTPHMARTYRCGMKPNtitkpdtPDH--CSFPEDL 191
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPD-------PKYnsCDAPEEI 46
 
Name Accession Description Interval E-value
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 308-724 2.64e-60

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 217.55  E-value: 2.64e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 308 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LTVAAGQHLLPKHY 386
Cdd:PLN02328 163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 387 HNKSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVwddKSFK----GVVVGR--GPQIVNGCINNPVALMCEQ- 459
Cdd:PLN02328 237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV---KTMKmkgdGVVAAAdlGGSVLTGINGNPLGVLARQl 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491     --------------------------------------------------------------------------------
Cdd:PLN02328 314 glplhkvrdicplylpdgkavdaeidskieasfnklldrvcklrqamieevksvdvnlgtaleafrhvykvaedpqerml 393

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 460 ------------------VSARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTdG 521
Cdd:PLN02328 394 lnwhlanleyanaslmsnLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVYAG-G 471

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 522 MGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQRGLFA 601
Cdd:PLN02328 472 QEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMRGEFF 548

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 602 VFYDMDS-QQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEI--PEPTKYFVTRWSTEPWIQMAYSFVKTF 678
Cdd:PLN02328 549 LFYSYSSvSGGPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFHPKGIvvPDPVQAVCTRWGKDCFTYGSYSYVAVG 628

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 568982491 679 GSGEAYDIIAEEI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 724
Cdd:PLN02328 629 SSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
405-726 4.15e-59

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 206.31  E-value: 4.15e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 405 RQLHNFGMKVTVLEAKDRIGGRVW-DDKSFKGVVVGRGPQ---------------------------------------- 443
Cdd:COG1231   24 RELRKAGLDVTVLEARDRVGGRVWtLRFGDDGLYAELGAMrippshtnllalarelglplepfpnengnallylggkrvr 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 444 --------------------------------------------------------IVNGCINNPVALMCEQVSARSWDH 467
Cdd:COG1231  104 ageiaadlrgvaellakllralaaaldpwahpaaeldreslaewlrrngaspsarrLLGLLGAGEYGADPDELSLLDLLR 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 468 NEFFAQFAGDHTLLTPGYSTIIEKLAEGL--DIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRgaIQF 545
Cdd:COG1231  184 YAASAGGGAQQFRIVGGMDQLPRALAAELgdRIRLGAPVTRIRQDGDGVTVTTDDGGTVRADAVIVTVPPSVLRR--IEF 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 546 NPPLSEKKMKAINSLGAGIIEKIALQFPYRFW--DSKVQGADFfghvppsaSQRGLFAVFYDMDSQQQS--VLMSVITGE 621
Cdd:COG1231  262 DPPLPAAKRAAIQRLPYGAAIKVFLQFDRPFWeeDGLYGGISL--------TDLPIRQTWYPSNGPDGGagVLLGYVGGD 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 622 AVASLRTMDDKQVLQQCMGILRELFKEqEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAeEIQGTVFFAGEA 701
Cdd:COG1231  334 DARALAALSPEERVAAALEQLARIFGV-YAAEPVDYVSTDWGRDPWSRGAYAAAPPGQLTAAGPALA-EPDGRIHFAGEH 411

                        410       420
                 ....*....|....*....|....*
gi 568982491 702 TNRHFPQTVTGAYLSGVREASKIAA 726
Cdd:COG1231  412 TSDEWPGWVEGALESGERAAAEILA 436
PLN03000 PLN03000
amine oxidase
 313-725 8.62e-58

amine oxidase


Pssm-ID: 178578 [Multi-domain]  Cd Length: 881  Bit Score: 211.42  E-value: 8.62e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 313 YLALRNLILALWYTNCKEALTPQKCIphiivrGLVRIRCVQEVERILYFMTRKGLINTGVltVAAGQHLLPKHYHNKSVL 392
Cdd:PLN03000 117 YILIRNHIISKWRENISSWVTKEMFL------GSIPKHCSSLLDSAYNYLVTHGYINFGI--AQAIKDKFPAQSSKSSVV 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 393 VVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDK---SFKGVVVGRGPQIVNGCINNPVALMCEQV--------- 460
Cdd:PLN03000 189 IVGAGLSGLAAARQLMRFGFKVTVLEGRKRPGGRVYTKKmeaNRVGAAADLGGSVLTGTLGNPLGIIARQLgsslykvrd 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491     --------------------------------------------------------------------------------
Cdd:PLN03000 269 kcplyrvdgkpvdpdvdlkvevafnqlldkasklrqlmgdvsmdvslgaaletfrqvsgndvateemglfnwhlanleya 348

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 461 --------SARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTDGMgHSAQKVLVT 532
Cdd:PLN03000 349 naglvsklSLAFWDQDDPY-DMGGDHCFLPGGNGRLVQALAENVPILYEKTVQTIRYGSNGVKVIAGNQV-YEGDMVLCT 426

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 533 VPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQRGLFAVFYDMDS-QQQ 611
Cdd:PLN03000 427 VPLGVLKNGSIKFVPELPQRKLDCIKRLGFGLLNKVAMLFPYVFWSTDL---DTFGHLTEDPNYRGEFFLFYSYAPvAGG 503

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 612 SVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEI--PEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAE 689
Cdd:PLN03000 504 PLLIALVAGEAAHKFETMPPTDAVTRVLHILRGIYEPQGInvPDPLQTVCTRWGGDPFSLGSYSNVAVGASGDDYDILAE 583

                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 568982491 690 EI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKIA 725
Cdd:PLN03000 584 SVgDGRLFFAGEATTRRYPATMHGAFVTGLREAANMA 620
PLN02976 PLN02976
amine oxidase
 447-724 1.09e-57

amine oxidase


Pssm-ID: 215527 [Multi-domain]  Cd Length: 1713  Bit Score: 213.19  E-value: 1.09e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491  447 GCinnpvALMCEQVSARSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDE----------VQV 516
Cdd:PLN02976  902 GC-----AALLKEVSLPYWNQDDVYGGFGGAHCMIKGGYSNVVESLAEGLDIHLNHVVTDVSYGSKDagasgssrkkVKV 976

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491  517 TTTDGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQ 596
Cdd:PLN02976  977 STSNGSEFLGDAVLITVPLGCLKAETIKFSPPLPDWKYSSIQRLGFGVLNKVVLEFPEVFWDDSV---DYFGATAEETDL 1053

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491  597 RGLFAVFYDMDSQQQS-VLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEIPEPTKYFVTRWSTEPWIQMAYSFV 675
Cdd:PLN02976 1054 RGQCFMFWNVKKTVGApVLIALVVGKAAIDGQSMSSSDHVNHALMVLRKLFGEALVPDPVASVVTDWGRDPFSYGAYSYV 1133

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 568982491  676 KTFGSGEAYDIIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 724
Cdd:PLN02976 1134 AIGASGEDYDILGRPVENCLFFAGEATCKEHPDTVGGAMMSGLREAVRI 1182
PLN02529 PLN02529
lysine-specific histone demethylase 1
 313-724 3.10e-56

lysine-specific histone demethylase 1


Pssm-ID: 178144 [Multi-domain]  Cd Length: 738  Bit Score: 205.13  E-value: 3.10e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 313 YLALRNLILALWYTNCKEALTpqkciphiivRGLVRIRCVQEVERILY----FMTRKGLINTGVLTVAAGQhlLPKHYHN 388
Cdd:PLN02529  93 YIVVRNHILARWRSNVGIWLS----------KGQIKETVSSEYEHLISaaydFLLYNGYINFGVSPSFASP--IPEEGTE 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 389 KSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDK-SFKG--VVVGRGPQIVNGCINNPVALMCEQVS---- 461
Cdd:PLN02529 161 GSVIIVGAGLAGLAAARQLLSFGFKVVVLEGRNRPGGRVYTQKmGRKGqfAAVDLGGSVITGIHANPLGVLARQLSiplh 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 462 ----------------------------------------------------------------ARS------------- 464
Cdd:PLN02529 241 kvrdncplykpdgalvdkeidsniefifnklldkvtelrqimggfandislgsvlerlrqlygvARSteerqlldwhlan 320

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 465 ----------------WDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTDGMgHSAQK 528
Cdd:PLN02529 321 leyanagclsdlsaayWDQDDPY-EMGGDHCFLAGGNWRLINALCEGVPIFYGKTVDTIKYGNDGVEVIAGSQV-FQADM 398

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 529 VLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQRGLFAVFYDMDS 608
Cdd:PLN02529 399 VLCTVPLGVLKKRTIRFEPELPRRKLAAIDRLGFGLLNKVAMVFPSVFWGEEL---DTFGCLNESSNKRGEFFLFYGYHT 475

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 609 -QQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELF--KEQEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYD 685
Cdd:PLN02529 476 vSGGPALVALVAGEAAQRFENTDPSTLLHRVLSVLRGIYnpKGINVPDPIQTICTRWGSDPLSYGSYSHVRVQSSGSDYD 555

                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 568982491 686 IIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 724
Cdd:PLN02529 556 ILAESVSGRLFFAGEATTRQYPATMHGAFLSGLREASRI 594
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 405-724 4.18e-56

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 198.10  E-value: 4.18e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491  405 RQLHNFGMKVTVLEAKDRIGGRVWDDKsFKGVVVGRGPQIVNGCiNNPVALMCEQVSARS-------------------- 464
Cdd:pfam01593   8 RELLRAGHDVTVLEARDRVGGRIRTVR-DDGFLIELGAMWFHGA-QPPLLALLKELGLEDrlvlpdpapfytvlfaggrr 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491      --------------------------------------------------------------------------------
Cdd:pfam01593  86 ypgdfrrvpagwegllefgrllsipeklrlglaalasdaldefdlddfslaesllflgrrgpgdvevwdrlidpelfaal 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491  465 -------------------WDHNEFFAQFAGDHTLLTPGYSTIIEKLAE---GLDIRLKSPVQSIDYTGDEVQVTTTDGM 522
Cdd:pfam01593 166 pfasgafagdpselsaglaLPLLWALLGEGGSLLLPRGGLGALPDALAAqllGGDVRLNTRVRSIDREGDGVTVTLTDGE 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491  523 GHSAQKVLVTVPLAILQRgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKvqgaDFFGHVPPSASQRGLFAV 602
Cdd:pfam01593 246 VIEADAVIVTVPLGVLKR--ILFTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWPDL----GLLGLLSELLTGLGTAFS 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491  603 FYDMDSQ----QQSVLMSVIT-GEAVASLRTMDDKQVLQQCMGILRELFKEqEIPEPTKYFVTRWSTEPWIQMAYSFVKT 677
Cdd:pfam01593 320 WLTFPNRappgKGLLLLVYVGpGDRARELEGLSDEELLQAVLRDLRKLFGE-EAPEPLRVLVSDWHTDPWPRGSYSLPQY 398

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 568982491  678 FGSGEAYDIIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 724
Cdd:pfam01593 399 GPGHDDYRPLARTPDPGLFFAGEHTSTGYPGTVEGAIESGRRAARAV 445
PLN02268 PLN02268
probable polyamine oxidase
 390-724 1.67e-47

probable polyamine oxidase


Pssm-ID: 177909 [Multi-domain]  Cd Length: 435  Bit Score: 174.11  E-value: 1.67e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 390 SVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDKSFkGVVVGRGPQIVNG-CINNPVA-------------- 454
Cdd:PLN02268   2 SVIVIGGGIAGIAAARALHDASFKVTLLESRDRIGGRVHTDYSF-GFPVDMGASWLHGvCNENPLApligrlglplyrts 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491     --------------------------------------------------------------------------------
Cdd:PLN02268  81 gdnsvlydhdlesyalfdmdgnqvpqelvtkvgetferileetekvrdeheedmsllqaisivlerhpelrleglahevl 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 455 --LMC----------EQVSARSWDHNEFFAqfaGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTDGM 522
Cdd:PLN02268 161 qwYLCrmegwfaadaDTISLKSWDQEELLE---GGHGLMVRGYDPVINTLAKGLDIRLNHRVTKIVRRYNGVKVTVEDGT 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 523 GHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSkvqgADFFGHVPPSASQRGLFAV 602
Cdd:PLN02268 238 TFVADAAIIAVPLGVLKANIIKFEPELPEWKEEAISDLGVGIENKIALHFDSVFWPN----VEFLGVVAPTSYGCSYFLN 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 603 FYdmDSQQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQeiPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGE 682
Cdd:PLN02268 314 LH--KATGHPVLVYMPAGRLARDIEKLSDEAAANFAMSQLKKMLPDA--TEPVQYLVSRWGSDPNSLGCYSYDLVGKPHD 389

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 568982491 683 AYDIIAEEIqGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 724
Cdd:PLN02268 390 LYERLRAPV-DNLFFAGEATSSDFPGSVHGAYSTGVMAAEEC 430
PLN02676 PLN02676
polyamine oxidase
 484-724 1.77e-33

polyamine oxidase


Pssm-ID: 215362 [Multi-domain]  Cd Length: 487  Bit Score: 134.84  E-value: 1.77e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 484 GYSTIIEKLAEG---------LDIRLK--SPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEK 552
Cdd:PLN02676 222 GYESLVYYLAEQflstksgkiTDPRLKlnKVVREISYSKNGVTVKTEDGSVYRAKYVIVSVSLGVLQSDLIKFKPPLPDW 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 553 KMKAINSLGAGIIEKIALQFPYRFWDSKvQGADFFGHvppSASQRGLFAVFYDMDSQQ--QSVLMSVITGEAVASLRTMD 630
Cdd:PLN02676 302 KIEAIYQFDMAVYTKIFLKFPYKFWPSG-PGTEFFLY---AHERRGYYPFWQHLENEYpgSNVLFVTVTDEESRRIEQQP 377

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 631 DKQVLQQCMGILRELFKEQeIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAEEIqGTVFFAGEATNRHFPQTV 710
Cdd:PLN02676 378 DSETKAEIMEVLRKMFGPN-IPEATDILVPRWWSNRFFKGSYSNWPIGVSRYEFDQIRAPV-GRVYFTGEHTSEKYNGYV 455

                        250
                 ....*....|....
gi 568982491 711 TGAYLSGVrEASKI 724
Cdd:PLN02676 456 HGAYLAGI-DTAND 468
PLN02568 PLN02568
polyamine oxidase
 474-724 2.38e-25

polyamine oxidase


Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 110.69  E-value: 2.38e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 474 FAGDHTLLTPGYSTIIEKLAEGLD---IRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRGAIQ----FN 546
Cdd:PLN02568 230 FPGEEITIAKGYLSVIEALASVLPpgtIQLGRKVTRIEWQDEPVKLHFADGSTMTADHVIVTVSLGVLKAGIGEdsglFS 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 547 PPLSEKKMKAINSLGAGIIEKIALQFPYRFwDSKVQGADFFghvpPSasqrgLFAVFYDMDSQQQ--------------- 611
Cdd:PLN02568 310 PPLPDFKTDAISRLGFGVVNKLFVELSPRP-DGSPEDVAKF----PF-----LQMAFHRSDSEARhdkipwwmrrtasic 379

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 612 ------SVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEIPEP---------------------TKYFVTRWST 664
Cdd:PLN02568 380 pihknsSVLLSWFAGKEALELEKLSDEEIIRGVQTTLSSFLKRRVAGLGsqshplcnggassndgsrwkfVKVLKSKWGT 459

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568982491 665 EPWIQMAYSFVKTFGSGEAYDIIAEEIQGT------------VFFAGEATNRHFPQTVTGAYLSGVREASKI 724
Cdd:PLN02568 460 DPLFLGSYSYVAVGSSGDDLDRMAEPLPRIsdhdqaggpplqLLFAGEATHRTHYSTTHGAYFSGLREANRL 531
PRK07233 PRK07233
hypothetical protein; Provisional
 484-562 9.71e-10

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 61.44  E-value: 9.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 484 GYSTIIEKLAE-----GLDIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRgaiqFNPPLSEK---KMK 555
Cdd:PRK07233 196 GFATLIDALAEaiearGGEIRLGTPVTSVVIDGGGVTGVEVDGEEEDFDAVISTAPPPILAR----LVPDLPADvlaRLR 271


                 ....*..
gi 568982491 556 AINSLGA 562
Cdd:PRK07233 272 RIDYQGV 278
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 484-662 9.90e-10

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 61.39  E-value: 9.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 484 GYSTIIEKLAEGL---DIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRgAIQFNPPLSEKKMKAINSL 560
Cdd:COG1232  208 GLGTLVEALAEALeagEIRLGTRVTAIEREGGGWRVTTSDGETIEADAVVSATPAPALAR-LLAPLPPEVAAALAGIPYA 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 561 GAGIiekIALQFPyrfwDSKVQGADFFGHVPPSASQRGLFAVFY------DMDSQQQSVLMSVITGEAVASLRTMDDKQV 634
Cdd:COG1232  287 SVAV---VALGFD----RPDLPPPDGFGWLVPRDEGVPILAVTFssnkwpHRAPDGKVLLRLEVGGAGDPELWQLSDEEL 359

                        170       180
                 ....*....|....*....|....*...
gi 568982491 635 LQQCMGILRELFKEQeiPEPTKYFVTRW 662
Cdd:COG1232  360 VALALADLRKLLGID--AEPVDTRVVRW 385
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-191 1.00e-08

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 51.54  E-value: 1.00e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568982491  138 YWVQCTKpeCGKWRQLTKEIQlTPHMARTYRCGMKPNtitkpdtPDH--CSFPEDL 191
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPD-------PKYnsCDAPEEI 46
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
401-542 1.46e-05

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 47.57  E-value: 1.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 401 LAAARQLHNFGMKVTVLEaKDR-IGGRV---------WD---------DKSFKGVvvgrgpqivngcinnpVALMCEQVS 461
Cdd:COG3380   16 LAAARALQDAGHEVTVFE-KSRgVGGRMatrrldggrFDhgaqyftarDPRFQAL----------------VEEWLAAGL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 462 ARSWDHNEFFAQFAGDHTLL---------TPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTDGMGHS-AQKVLV 531
Cdd:COG3380   79 VAPWTFDFVVLDADGLVSPRddgepryvgVPGMNALAKHLAAGLDVRLGTRVTALERDGDGWRLTDEDGEEYGpFDAVVL 158

                        170
                 ....*....|....*
gi 568982491 532 TVP----LAILQRGA 542
Cdd:COG3380  159 AIPapqaAALLEPSL 173
SWIRM pfam04433
SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid ...
 298-369 4.39e-05

SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in chromosomal proteins. It contains a helix-turn helix motif and binds to DNA.


Pssm-ID: 461307 [Multi-domain]  Cd Length: 78  Bit Score: 42.16  E-value: 4.39e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568982491  298 DELYEFPEY----SRDPTMYLALRNLILALWYTNCKEALTPQKCiphiivRGLVRIrCVQEVERILYFMTRKGLIN 369
Cdd:pfam04433   9 IEKRLLPEFfngkSKTPEVYLEIRNFILNLWRENPKEYLTKTDA------RRALKG-DVNLISRIHEFLERWGLIN 77
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 407-533 5.43e-03

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 40.07  E-value: 5.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982491 407 LHNFGMKVTVLEAKDRIGGRvwddksfkgvvvgrgpqivngcinnpvalMCEQVSArswdhnEFFAQFAgdhtlltpgys 486
Cdd:COG1249  187 FARLGSEVTLVERGDRLLPG-----------------------------EDPEISE------ALEKALE----------- 220

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 568982491 487 tiieklAEGLDIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQ---KVLVTV 533
Cdd:COG1249  221 ------KEGIDILTGAKVTSVEKTGDGVTVTLEDGGGEEAVeadKVLVAT 264
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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