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Conserved domains on  [gi|568982483|ref|XP_006516979|]
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lysine-specific histone demethylase 1B isoform X4 [Mus musculus]

Protein Classification

lysine-specific histone demethylase 1B( domain architecture ID 13726372)

lysine-specific histone demethylase 1B (KDM1B) demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor

EC:  1.14.99.66
Gene Symbol:  KDM1B
Gene Ontology:  GO:0008270|GO:0050660|GO:0032452|GO:0042393
PubMed:  23266887|23260659

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02328 super family cl33466
lysine-specific histone demethylase 1 homolog
 315-731 3.04e-60

lysine-specific histone demethylase 1 homolog


The actual alignment was detected with superfamily member PLN02328:

Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 217.55  E-value: 3.04e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 315 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LTVAAGQHLLPKHY 393
Cdd:PLN02328 163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 394 HNKSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVwddKSFK----GVVVGR--GPQIVNGCINNPVALMCEQ- 466
Cdd:PLN02328 237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV---KTMKmkgdGVVAAAdlGGSVLTGINGNPLGVLARQl 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483     --------------------------------------------------------------------------------
Cdd:PLN02328 314 glplhkvrdicplylpdgkavdaeidskieasfnklldrvcklrqamieevksvdvnlgtaleafrhvykvaedpqerml 393

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 467 ------------------VSARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTdG 528
Cdd:PLN02328 394 lnwhlanleyanaslmsnLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVYAG-G 471

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 529 MGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQRGLFA 608
Cdd:PLN02328 472 QEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMRGEFF 548

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 609 VFYDMDS-QQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEI--PEPTKYFVTRWSTEPWIQMAYSFVKTF 685
Cdd:PLN02328 549 LFYSYSSvSGGPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFHPKGIvvPDPVQAVCTRWGKDCFTYGSYSYVAVG 628

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 568982483 686 GSGEAYDIIAEEI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 731
Cdd:PLN02328 629 SSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-198 7.02e-08

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


:

Pssm-ID: 462181  Cd Length: 46  Bit Score: 49.23  E-value: 7.02e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568982483  138 YWVQCTKpeCGKWRQLTKEIQlTPHMARTYRCGMKPNtitKWDISellpdtpdhCSFPEDL 198
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPD---PKYNS---------CDAPEEI 46
 
Name Accession Description Interval E-value
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 315-731 3.04e-60

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 217.55  E-value: 3.04e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 315 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LTVAAGQHLLPKHY 393
Cdd:PLN02328 163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 394 HNKSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVwddKSFK----GVVVGR--GPQIVNGCINNPVALMCEQ- 466
Cdd:PLN02328 237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV---KTMKmkgdGVVAAAdlGGSVLTGINGNPLGVLARQl 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483     --------------------------------------------------------------------------------
Cdd:PLN02328 314 glplhkvrdicplylpdgkavdaeidskieasfnklldrvcklrqamieevksvdvnlgtaleafrhvykvaedpqerml 393

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 467 ------------------VSARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTdG 528
Cdd:PLN02328 394 lnwhlanleyanaslmsnLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVYAG-G 471

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 529 MGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQRGLFA 608
Cdd:PLN02328 472 QEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMRGEFF 548

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 609 VFYDMDS-QQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEI--PEPTKYFVTRWSTEPWIQMAYSFVKTF 685
Cdd:PLN02328 549 LFYSYSSvSGGPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFHPKGIvvPDPVQAVCTRWGKDCFTYGSYSYVAVG 628

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 568982483 686 GSGEAYDIIAEEI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 731
Cdd:PLN02328 629 SSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
412-733 4.59e-59

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 206.31  E-value: 4.59e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 412 RQLHNFGMKVTVLEAKDRIGGRVW-DDKSFKGVVVGRGPQ---------------------------------------- 450
Cdd:COG1231   24 RELRKAGLDVTVLEARDRVGGRVWtLRFGDDGLYAELGAMrippshtnllalarelglplepfpnengnallylggkrvr 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 451 --------------------------------------------------------IVNGCINNPVALMCEQVSARSWDH 474
Cdd:COG1231  104 ageiaadlrgvaellakllralaaaldpwahpaaeldreslaewlrrngaspsarrLLGLLGAGEYGADPDELSLLDLLR 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 475 NEFFAQFAGDHTLLTPGYSTIIEKLAEGL--DIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRgaIQF 552
Cdd:COG1231  184 YAASAGGGAQQFRIVGGMDQLPRALAAELgdRIRLGAPVTRIRQDGDGVTVTTDDGGTVRADAVIVTVPPSVLRR--IEF 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 553 NPPLSEKKMKAINSLGAGIIEKIALQFPYRFW--DSKVQGADFfghvppsaSQRGLFAVFYDMDSQQQS--VLMSVITGE 628
Cdd:COG1231  262 DPPLPAAKRAAIQRLPYGAAIKVFLQFDRPFWeeDGLYGGISL--------TDLPIRQTWYPSNGPDGGagVLLGYVGGD 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 629 AVASLRTMDDKQVLQQCMGILRELFKEqEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAeEIQGTVFFAGEA 708
Cdd:COG1231  334 DARALAALSPEERVAAALEQLARIFGV-YAAEPVDYVSTDWGRDPWSRGAYAAAPPGQLTAAGPALA-EPDGRIHFAGEH 411

                        410       420
                 ....*....|....*....|....*
gi 568982483 709 TNRHFPQTVTGAYLSGVREASKIAA 733
Cdd:COG1231  412 TSDEWPGWVEGALESGERAAAEILA 436
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 412-731 4.58e-56

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 198.10  E-value: 4.58e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483  412 RQLHNFGMKVTVLEAKDRIGGRVWDDKsFKGVVVGRGPQIVNGCiNNPVALMCEQVSARS-------------------- 471
Cdd:pfam01593   8 RELLRAGHDVTVLEARDRVGGRIRTVR-DDGFLIELGAMWFHGA-QPPLLALLKELGLEDrlvlpdpapfytvlfaggrr 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483      --------------------------------------------------------------------------------
Cdd:pfam01593  86 ypgdfrrvpagwegllefgrllsipeklrlglaalasdaldefdlddfslaesllflgrrgpgdvevwdrlidpelfaal 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483  472 -------------------WDHNEFFAQFAGDHTLLTPGYSTIIEKLAE---GLDIRLKSPVQSIDYTGDEVQVTTTDGM 529
Cdd:pfam01593 166 pfasgafagdpselsaglaLPLLWALLGEGGSLLLPRGGLGALPDALAAqllGGDVRLNTRVRSIDREGDGVTVTLTDGE 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483  530 GHSAQKVLVTVPLAILQRgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKvqgaDFFGHVPPSASQRGLFAV 609
Cdd:pfam01593 246 VIEADAVIVTVPLGVLKR--ILFTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWPDL----GLLGLLSELLTGLGTAFS 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483  610 FYDMDSQ----QQSVLMSVIT-GEAVASLRTMDDKQVLQQCMGILRELFKEqEIPEPTKYFVTRWSTEPWIQMAYSFVKT 684
Cdd:pfam01593 320 WLTFPNRappgKGLLLLVYVGpGDRARELEGLSDEELLQAVLRDLRKLFGE-EAPEPLRVLVSDWHTDPWPRGSYSLPQY 398

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 568982483  685 FGSGEAYDIIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 731
Cdd:pfam01593 399 GPGHDDYRPLARTPDPGLFFAGEHTSTGYPGTVEGAIESGRRAARAV 445
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-198 7.02e-08

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 49.23  E-value: 7.02e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568982483  138 YWVQCTKpeCGKWRQLTKEIQlTPHMARTYRCGMKPNtitKWDISellpdtpdhCSFPEDL 198
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPD---PKYNS---------CDAPEEI 46
 
Name Accession Description Interval E-value
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 315-731 3.04e-60

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 217.55  E-value: 3.04e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 315 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LTVAAGQHLLPKHY 393
Cdd:PLN02328 163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 394 HNKSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVwddKSFK----GVVVGR--GPQIVNGCINNPVALMCEQ- 466
Cdd:PLN02328 237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV---KTMKmkgdGVVAAAdlGGSVLTGINGNPLGVLARQl 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483     --------------------------------------------------------------------------------
Cdd:PLN02328 314 glplhkvrdicplylpdgkavdaeidskieasfnklldrvcklrqamieevksvdvnlgtaleafrhvykvaedpqerml 393

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 467 ------------------VSARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTdG 528
Cdd:PLN02328 394 lnwhlanleyanaslmsnLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVYAG-G 471

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 529 MGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQRGLFA 608
Cdd:PLN02328 472 QEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMRGEFF 548

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 609 VFYDMDS-QQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEI--PEPTKYFVTRWSTEPWIQMAYSFVKTF 685
Cdd:PLN02328 549 LFYSYSSvSGGPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFHPKGIvvPDPVQAVCTRWGKDCFTYGSYSYVAVG 628

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*..
gi 568982483 686 GSGEAYDIIAEEI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 731
Cdd:PLN02328 629 SSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
412-733 4.59e-59

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 206.31  E-value: 4.59e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 412 RQLHNFGMKVTVLEAKDRIGGRVW-DDKSFKGVVVGRGPQ---------------------------------------- 450
Cdd:COG1231   24 RELRKAGLDVTVLEARDRVGGRVWtLRFGDDGLYAELGAMrippshtnllalarelglplepfpnengnallylggkrvr 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 451 --------------------------------------------------------IVNGCINNPVALMCEQVSARSWDH 474
Cdd:COG1231  104 ageiaadlrgvaellakllralaaaldpwahpaaeldreslaewlrrngaspsarrLLGLLGAGEYGADPDELSLLDLLR 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 475 NEFFAQFAGDHTLLTPGYSTIIEKLAEGL--DIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRgaIQF 552
Cdd:COG1231  184 YAASAGGGAQQFRIVGGMDQLPRALAAELgdRIRLGAPVTRIRQDGDGVTVTTDDGGTVRADAVIVTVPPSVLRR--IEF 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 553 NPPLSEKKMKAINSLGAGIIEKIALQFPYRFW--DSKVQGADFfghvppsaSQRGLFAVFYDMDSQQQS--VLMSVITGE 628
Cdd:COG1231  262 DPPLPAAKRAAIQRLPYGAAIKVFLQFDRPFWeeDGLYGGISL--------TDLPIRQTWYPSNGPDGGagVLLGYVGGD 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 629 AVASLRTMDDKQVLQQCMGILRELFKEqEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAeEIQGTVFFAGEA 708
Cdd:COG1231  334 DARALAALSPEERVAAALEQLARIFGV-YAAEPVDYVSTDWGRDPWSRGAYAAAPPGQLTAAGPALA-EPDGRIHFAGEH 411

                        410       420
                 ....*....|....*....|....*
gi 568982483 709 TNRHFPQTVTGAYLSGVREASKIAA 733
Cdd:COG1231  412 TSDEWPGWVEGALESGERAAAEILA 436
PLN03000 PLN03000
amine oxidase
 320-732 9.95e-58

amine oxidase


Pssm-ID: 178578 [Multi-domain]  Cd Length: 881  Bit Score: 211.42  E-value: 9.95e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 320 YLALRNLILALWYTNCKEALTPQKCIphiivrGLVRIRCVQEVERILYFMTRKGLINTGVltVAAGQHLLPKHYHNKSVL 399
Cdd:PLN03000 117 YILIRNHIISKWRENISSWVTKEMFL------GSIPKHCSSLLDSAYNYLVTHGYINFGI--AQAIKDKFPAQSSKSSVV 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 400 VVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDK---SFKGVVVGRGPQIVNGCINNPVALMCEQV--------- 467
Cdd:PLN03000 189 IVGAGLSGLAAARQLMRFGFKVTVLEGRKRPGGRVYTKKmeaNRVGAAADLGGSVLTGTLGNPLGIIARQLgsslykvrd 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483     --------------------------------------------------------------------------------
Cdd:PLN03000 269 kcplyrvdgkpvdpdvdlkvevafnqlldkasklrqlmgdvsmdvslgaaletfrqvsgndvateemglfnwhlanleya 348

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 468 --------SARSWDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTDGMgHSAQKVLVT 539
Cdd:PLN03000 349 naglvsklSLAFWDQDDPY-DMGGDHCFLPGGNGRLVQALAENVPILYEKTVQTIRYGSNGVKVIAGNQV-YEGDMVLCT 426

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 540 VPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQRGLFAVFYDMDS-QQQ 618
Cdd:PLN03000 427 VPLGVLKNGSIKFVPELPQRKLDCIKRLGFGLLNKVAMLFPYVFWSTDL---DTFGHLTEDPNYRGEFFLFYSYAPvAGG 503

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 619 SVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEI--PEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAE 696
Cdd:PLN03000 504 PLLIALVAGEAAHKFETMPPTDAVTRVLHILRGIYEPQGInvPDPLQTVCTRWGGDPFSLGSYSNVAVGASGDDYDILAE 583

                        490       500       510
                 ....*....|....*....|....*....|....*..
gi 568982483 697 EI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKIA 732
Cdd:PLN03000 584 SVgDGRLFFAGEATTRRYPATMHGAFVTGLREAANMA 620
PLN02976 PLN02976
amine oxidase
 454-731 1.22e-57

amine oxidase


Pssm-ID: 215527 [Multi-domain]  Cd Length: 1713  Bit Score: 213.19  E-value: 1.22e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483  454 GCinnpvALMCEQVSARSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDE----------VQV 523
Cdd:PLN02976  902 GC-----AALLKEVSLPYWNQDDVYGGFGGAHCMIKGGYSNVVESLAEGLDIHLNHVVTDVSYGSKDagasgssrkkVKV 976

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483  524 TTTDGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQ 603
Cdd:PLN02976  977 STSNGSEFLGDAVLITVPLGCLKAETIKFSPPLPDWKYSSIQRLGFGVLNKVVLEFPEVFWDDSV---DYFGATAEETDL 1053

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483  604 RGLFAVFYDMDSQQQS-VLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEIPEPTKYFVTRWSTEPWIQMAYSFV 682
Cdd:PLN02976 1054 RGQCFMFWNVKKTVGApVLIALVVGKAAIDGQSMSSSDHVNHALMVLRKLFGEALVPDPVASVVTDWGRDPFSYGAYSYV 1133

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 568982483  683 KTFGSGEAYDIIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 731
Cdd:PLN02976 1134 AIGASGEDYDILGRPVENCLFFAGEATCKEHPDTVGGAMMSGLREAVRI 1182
PLN02529 PLN02529
lysine-specific histone demethylase 1
 320-731 3.35e-56

lysine-specific histone demethylase 1


Pssm-ID: 178144 [Multi-domain]  Cd Length: 738  Bit Score: 205.13  E-value: 3.35e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 320 YLALRNLILALWYTNCKEALTpqkciphiivRGLVRIRCVQEVERILY----FMTRKGLINTGVLTVAAGQhlLPKHYHN 395
Cdd:PLN02529  93 YIVVRNHILARWRSNVGIWLS----------KGQIKETVSSEYEHLISaaydFLLYNGYINFGVSPSFASP--IPEEGTE 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 396 KSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDK-SFKG--VVVGRGPQIVNGCINNPVALMCEQVS---- 468
Cdd:PLN02529 161 GSVIIVGAGLAGLAAARQLLSFGFKVVVLEGRNRPGGRVYTQKmGRKGqfAAVDLGGSVITGIHANPLGVLARQLSiplh 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 469 ----------------------------------------------------------------ARS------------- 471
Cdd:PLN02529 241 kvrdncplykpdgalvdkeidsniefifnklldkvtelrqimggfandislgsvlerlrqlygvARSteerqlldwhlan 320

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 472 ----------------WDHNEFFaQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTDGMgHSAQK 535
Cdd:PLN02529 321 leyanagclsdlsaayWDQDDPY-EMGGDHCFLAGGNWRLINALCEGVPIFYGKTVDTIKYGNDGVEVIAGSQV-FQADM 398

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 536 VLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASQRGLFAVFYDMDS 615
Cdd:PLN02529 399 VLCTVPLGVLKKRTIRFEPELPRRKLAAIDRLGFGLLNKVAMVFPSVFWGEEL---DTFGCLNESSNKRGEFFLFYGYHT 475

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 616 -QQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELF--KEQEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYD 692
Cdd:PLN02529 476 vSGGPALVALVAGEAAQRFENTDPSTLLHRVLSVLRGIYnpKGINVPDPIQTICTRWGSDPLSYGSYSHVRVQSSGSDYD 555

                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 568982483 693 IIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 731
Cdd:PLN02529 556 ILAESVSGRLFFAGEATTRQYPATMHGAFLSGLREASRI 594
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 412-731 4.58e-56

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 198.10  E-value: 4.58e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483  412 RQLHNFGMKVTVLEAKDRIGGRVWDDKsFKGVVVGRGPQIVNGCiNNPVALMCEQVSARS-------------------- 471
Cdd:pfam01593   8 RELLRAGHDVTVLEARDRVGGRIRTVR-DDGFLIELGAMWFHGA-QPPLLALLKELGLEDrlvlpdpapfytvlfaggrr 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483      --------------------------------------------------------------------------------
Cdd:pfam01593  86 ypgdfrrvpagwegllefgrllsipeklrlglaalasdaldefdlddfslaesllflgrrgpgdvevwdrlidpelfaal 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483  472 -------------------WDHNEFFAQFAGDHTLLTPGYSTIIEKLAE---GLDIRLKSPVQSIDYTGDEVQVTTTDGM 529
Cdd:pfam01593 166 pfasgafagdpselsaglaLPLLWALLGEGGSLLLPRGGLGALPDALAAqllGGDVRLNTRVRSIDREGDGVTVTLTDGE 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483  530 GHSAQKVLVTVPLAILQRgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKvqgaDFFGHVPPSASQRGLFAV 609
Cdd:pfam01593 246 VIEADAVIVTVPLGVLKR--ILFTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWPDL----GLLGLLSELLTGLGTAFS 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483  610 FYDMDSQ----QQSVLMSVIT-GEAVASLRTMDDKQVLQQCMGILRELFKEqEIPEPTKYFVTRWSTEPWIQMAYSFVKT 684
Cdd:pfam01593 320 WLTFPNRappgKGLLLLVYVGpGDRARELEGLSDEELLQAVLRDLRKLFGE-EAPEPLRVLVSDWHTDPWPRGSYSLPQY 398

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 568982483  685 FGSGEAYDIIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 731
Cdd:pfam01593 399 GPGHDDYRPLARTPDPGLFFAGEHTSTGYPGTVEGAIESGRRAARAV 445
PLN02268 PLN02268
probable polyamine oxidase
 397-731 1.77e-47

probable polyamine oxidase


Pssm-ID: 177909 [Multi-domain]  Cd Length: 435  Bit Score: 174.11  E-value: 1.77e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 397 SVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDKSFkGVVVGRGPQIVNG-CINNPVA-------------- 461
Cdd:PLN02268   2 SVIVIGGGIAGIAAARALHDASFKVTLLESRDRIGGRVHTDYSF-GFPVDMGASWLHGvCNENPLApligrlglplyrts 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483     --------------------------------------------------------------------------------
Cdd:PLN02268  81 gdnsvlydhdlesyalfdmdgnqvpqelvtkvgetferileetekvrdeheedmsllqaisivlerhpelrleglahevl 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 462 --LMC----------EQVSARSWDHNEFFAqfaGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTDGM 529
Cdd:PLN02268 161 qwYLCrmegwfaadaDTISLKSWDQEELLE---GGHGLMVRGYDPVINTLAKGLDIRLNHRVTKIVRRYNGVKVTVEDGT 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 530 GHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSkvqgADFFGHVPPSASQRGLFAV 609
Cdd:PLN02268 238 TFVADAAIIAVPLGVLKANIIKFEPELPEWKEEAISDLGVGIENKIALHFDSVFWPN----VEFLGVVAPTSYGCSYFLN 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 610 FYdmDSQQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQeiPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGE 689
Cdd:PLN02268 314 LH--KATGHPVLVYMPAGRLARDIEKLSDEAAANFAMSQLKKMLPDA--TEPVQYLVSRWGSDPNSLGCYSYDLVGKPHD 389

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|..
gi 568982483 690 AYDIIAEEIqGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 731
Cdd:PLN02268 390 LYERLRAPV-DNLFFAGEATSSDFPGSVHGAYSTGVMAAEEC 430
PLN02676 PLN02676
polyamine oxidase
 491-731 1.83e-33

polyamine oxidase


Pssm-ID: 215362 [Multi-domain]  Cd Length: 487  Bit Score: 134.84  E-value: 1.83e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 491 GYSTIIEKLAEG---------LDIRLK--SPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEK 559
Cdd:PLN02676 222 GYESLVYYLAEQflstksgkiTDPRLKlnKVVREISYSKNGVTVKTEDGSVYRAKYVIVSVSLGVLQSDLIKFKPPLPDW 301

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 560 KMKAINSLGAGIIEKIALQFPYRFWDSKvQGADFFGHvppSASQRGLFAVFYDMDSQQ--QSVLMSVITGEAVASLRTMD 637
Cdd:PLN02676 302 KIEAIYQFDMAVYTKIFLKFPYKFWPSG-PGTEFFLY---AHERRGYYPFWQHLENEYpgSNVLFVTVTDEESRRIEQQP 377

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 638 DKQVLQQCMGILRELFKEQeIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAEEIqGTVFFAGEATNRHFPQTV 717
Cdd:PLN02676 378 DSETKAEIMEVLRKMFGPN-IPEATDILVPRWWSNRFFKGSYSNWPIGVSRYEFDQIRAPV-GRVYFTGEHTSEKYNGYV 455

                        250
                 ....*....|....
gi 568982483 718 TGAYLSGVrEASKI 731
Cdd:PLN02676 456 HGAYLAGI-DTAND 468
PLN02568 PLN02568
polyamine oxidase
 481-731 2.43e-25

polyamine oxidase


Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 110.69  E-value: 2.43e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 481 FAGDHTLLTPGYSTIIEKLAEGLD---IRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRGAIQ----FN 553
Cdd:PLN02568 230 FPGEEITIAKGYLSVIEALASVLPpgtIQLGRKVTRIEWQDEPVKLHFADGSTMTADHVIVTVSLGVLKAGIGEdsglFS 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 554 PPLSEKKMKAINSLGAGIIEKIALQFPYRFwDSKVQGADFFghvpPSasqrgLFAVFYDMDSQQQ--------------- 618
Cdd:PLN02568 310 PPLPDFKTDAISRLGFGVVNKLFVELSPRP-DGSPEDVAKF----PF-----LQMAFHRSDSEARhdkipwwmrrtasic 379

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 619 ------SVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEIPEP---------------------TKYFVTRWST 671
Cdd:PLN02568 380 pihknsSVLLSWFAGKEALELEKLSDEEIIRGVQTTLSSFLKRRVAGLGsqshplcnggassndgsrwkfVKVLKSKWGT 459

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568982483 672 EPWIQMAYSFVKTFGSGEAYDIIAEEIQGT------------VFFAGEATNRHFPQTVTGAYLSGVREASKI 731
Cdd:PLN02568 460 DPLFLGSYSYVAVGSSGDDLDRMAEPLPRIsdhdqaggpplqLLFAGEATHRTHYSTTHGAYFSGLREANRL 531
PRK07233 PRK07233
hypothetical protein; Provisional
 491-569 9.84e-10

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 61.44  E-value: 9.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 491 GYSTIIEKLAE-----GLDIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRgaiqFNPPLSEK---KMK 562
Cdd:PRK07233 196 GFATLIDALAEaiearGGEIRLGTPVTSVVIDGGGVTGVEVDGEEEDFDAVISTAPPPILAR----LVPDLPADvlaRLR 271


                 ....*..
gi 568982483 563 AINSLGA 569
Cdd:PRK07233 272 RIDYQGV 278
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 491-669 1.00e-09

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 61.39  E-value: 1.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 491 GYSTIIEKLAEGL---DIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRgAIQFNPPLSEKKMKAINSL 567
Cdd:COG1232  208 GLGTLVEALAEALeagEIRLGTRVTAIEREGGGWRVTTSDGETIEADAVVSATPAPALAR-LLAPLPPEVAAALAGIPYA 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 568 GAGIiekIALQFPyrfwDSKVQGADFFGHVPPSASQRGLFAVFY------DMDSQQQSVLMSVITGEAVASLRTMDDKQV 641
Cdd:COG1232  287 SVAV---VALGFD----RPDLPPPDGFGWLVPRDEGVPILAVTFssnkwpHRAPDGKVLLRLEVGGAGDPELWQLSDEEL 359

                        170       180
                 ....*....|....*....|....*...
gi 568982483 642 LQQCMGILRELFKEQeiPEPTKYFVTRW 669
Cdd:COG1232  360 VALALADLRKLLGID--AEPVDTRVVRW 385
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-198 7.02e-08

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 49.23  E-value: 7.02e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568982483  138 YWVQCTKpeCGKWRQLTKEIQlTPHMARTYRCGMKPNtitKWDISellpdtpdhCSFPEDL 198
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPD---PKYNS---------CDAPEEI 46
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
408-549 1.49e-05

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 47.57  E-value: 1.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 408 LAAARQLHNFGMKVTVLEaKDR-IGGRV---------WD---------DKSFKGVvvgrgpqivngcinnpVALMCEQVS 468
Cdd:COG3380   16 LAAARALQDAGHEVTVFE-KSRgVGGRMatrrldggrFDhgaqyftarDPRFQAL----------------VEEWLAAGL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 469 ARSWDHNEFFAQFAGDHTLL---------TPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTDGMGHS-AQKVLV 538
Cdd:COG3380   79 VAPWTFDFVVLDADGLVSPRddgepryvgVPGMNALAKHLAAGLDVRLGTRVTALERDGDGWRLTDEDGEEYGpFDAVVL 158

                        170
                 ....*....|....*
gi 568982483 539 TVP----LAILQRGA 549
Cdd:COG3380  159 AIPapqaAALLEPSL 173
SWIRM pfam04433
SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid ...
 305-376 4.44e-05

SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in chromosomal proteins. It contains a helix-turn helix motif and binds to DNA.


Pssm-ID: 461307 [Multi-domain]  Cd Length: 78  Bit Score: 42.16  E-value: 4.44e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568982483  305 DELYEFPEY----SRDPTMYLALRNLILALWYTNCKEALTPQKCiphiivRGLVRIrCVQEVERILYFMTRKGLIN 376
Cdd:pfam04433   9 IEKRLLPEFfngkSKTPEVYLEIRNFILNLWRENPKEYLTKTDA------RRALKG-DVNLISRIHEFLERWGLIN 77
Lpd COG1249
Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex ...
 414-540 5.49e-03

Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase [Energy production and conversion]; Dihydrolipoamide dehydrogenase (E3) component of pyruvate/2-oxoglutarate dehydrogenase complex or glutathione oxidoreductase is part of the Pathway/BioSystem: Glycine cleavagePyruvate oxidation


Pssm-ID: 440861 [Multi-domain]  Cd Length: 456  Bit Score: 40.07  E-value: 5.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982483 414 LHNFGMKVTVLEAKDRIGGRvwddksfkgvvvgrgpqivngcinnpvalMCEQVSArswdhnEFFAQFAgdhtlltpgys 493
Cdd:COG1249  187 FARLGSEVTLVERGDRLLPG-----------------------------EDPEISE------ALEKALE----------- 220

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 568982483 494 tiieklAEGLDIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQ---KVLVTV 540
Cdd:COG1249  221 ------KEGIDILTGAKVTSVEKTGDGVTVTLEDGGGEEAVeadKVLVAT 264
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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