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Conserved domains on  [gi|568964344|ref|XP_006512427|]
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leucine-rich repeat-containing protein 2 isoform X1 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
113-360 3.36e-38

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.61  E-value: 3.36e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 113 LSGTQWKELPDSLKEQTHLKEWYIHSTLIQIIPTYIELFQAMKILDLPKNQITCLPAEIGRLKNLKELNVSFNHLKSIPP 192
Cdd:COG4886  120 LSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 193 ELGDCEHLERLDCSGNlDLMDLPFELSNLKQVTFVDISANKFSSVPiCVLRMCRLQWLDISSNNLSDLPqDIDRLEELQG 272
Cdd:COG4886  200 PLGNLTNLEELDLSGN-QLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKT 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 273 FLLYKNKLTYlpqamLNLKKLTLLVVSGDHLVEVPTALCDASTPLKFVSLVDNPIDKTGCQDTEDTVESERDRQHFDKEF 352
Cdd:COG4886  277 LDLSNNQLTD-----LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351


                 ....*...
gi 568964344 353 MKAYIEDL 360
Cdd:COG4886  352 LLLLLNLL 359
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
113-360 3.36e-38

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.61  E-value: 3.36e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 113 LSGTQWKELPDSLKEQTHLKEWYIHSTLIQIIPTYIELFQAMKILDLPKNQITCLPAEIGRLKNLKELNVSFNHLKSIPP 192
Cdd:COG4886  120 LSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 193 ELGDCEHLERLDCSGNlDLMDLPFELSNLKQVTFVDISANKFSSVPiCVLRMCRLQWLDISSNNLSDLPqDIDRLEELQG 272
Cdd:COG4886  200 PLGNLTNLEELDLSGN-QLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKT 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 273 FLLYKNKLTYlpqamLNLKKLTLLVVSGDHLVEVPTALCDASTPLKFVSLVDNPIDKTGCQDTEDTVESERDRQHFDKEF 352
Cdd:COG4886  277 LDLSNNQLTD-----LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351


                 ....*...
gi 568964344 353 MKAYIEDL 360
Cdd:COG4886  352 LLLLLNLL 359
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 140-296 6.03e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 76.43  E-value: 6.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 140 LIQIIPTYIELFQAMKILDLPKNQITC-LPAEIGRLKNLKELNVSFNHLK-SIPPELGDCEHLERLDCSGNLDLMDLPFE 217
Cdd:PLN00113 176 LVGKIPNSLTNLTSLEFLTLASNQLVGqIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTGPIPSS 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 218 LSNLKQVTFVDISANKFS-SVPICVLRMCRLQWLDISSNNLS-DLPQDIDRLEELQGFLLYKNKLT-YLPQAMLNLKKLT 294
Cdd:PLN00113 256 LGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQ 335


                 ..
gi 568964344 295 LL 296
Cdd:PLN00113 336 VL 337
LRR_8 pfam13855
Leucine rich repeat;
246-303 5.88e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 5.88e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344  246 RLQWLDISSNNLSDLPQDI-DRLEELQGFLLYKNKLTYL-PQAMLNLKKLTLLVVSGDHL 303
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 155-208 7.25e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 7.25e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568964344 155 KILDLPKNQITCLpAEIGRLKNLKELNVSFNHLKSIP---PELGDCEHLERLDCSGN 208
Cdd:cd21340  123 RVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
LRR smart00370
Leucine-rich repeats, outliers;
174-197 5.13e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 5.13e-03
                           10        20
                   ....*....|....*....|....
gi 568964344   174 LKNLKELNVSFNHLKSIPPELGDC 197
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
113-360 3.36e-38

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 141.61  E-value: 3.36e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 113 LSGTQWKELPDSLKEQTHLKEWYIHSTLIQIIPTYIELFQAMKILDLPKNQITCLPAEIGRLKNLKELNVSFNHLKSIPP 192
Cdd:COG4886  120 LSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 193 ELGDCEHLERLDCSGNlDLMDLPFELSNLKQVTFVDISANKFSSVPiCVLRMCRLQWLDISSNNLSDLPqDIDRLEELQG 272
Cdd:COG4886  200 PLGNLTNLEELDLSGN-QLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKT 276

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 273 FLLYKNKLTYlpqamLNLKKLTLLVVSGDHLVEVPTALCDASTPLKFVSLVDNPIDKTGCQDTEDTVESERDRQHFDKEF 352
Cdd:COG4886  277 LDLSNNQLTD-----LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351


                 ....*...
gi 568964344 353 MKAYIEDL 360
Cdd:COG4886  352 LLLLLNLL 359
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
122-303 9.93e-37

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 137.76  E-value: 9.93e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 122 PDSLKEQTHLKEWYIHSTLIQIIPTYIELFQAMKILDLPKNQITCLPAEIGRLKNLKELNVSFNHLKSIPPELGDCEHLE 201
Cdd:COG4886  106 NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLK 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 202 RLDCSGNlDLMDLPFELSNLKQVTFVDISANKFSSVPICVLRMCRLQWLDISSNNLSDLPqDIDRLEELQGFLLYKNKLT 281
Cdd:COG4886  186 ELDLSNN-QITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263

                        170       180
                 ....*....|....*....|..
gi 568964344 282 YLPQAmLNLKKLTLLVVSGDHL 303
Cdd:COG4886  264 DLPPL-ANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
112-306 1.85e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.08  E-value: 1.85e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 112 ELSGTQWKELPDSLKEQTHLKEWYIHSTLIQIIPTYIELFQAMKILDLPKNQITCLPAEIGRLKNLKELNVSFNHLKSIp 191
Cdd:COG4886  165 DLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL- 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 192 PELGDCEHLERLDCSGNlDLMDLPfELSNLKQVTFVDISANKFSSVPICVLRMCRLQWLDISSNNLSDLPQDIDRLEELQ 271
Cdd:COG4886  244 PELGNLTNLEELDLSNN-QLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 568964344 272 GFLLYKNKLTYLPQAMLNLKKLTLLVVSGDHLVEV 306
Cdd:COG4886  322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLL 356
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
138-327 1.74e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.22  E-value: 1.74e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 138 STLIQIIPTYIELFQAMKILDLPKNQITCLPAEIGRLKNLKELNVSFNHLKSIPPELGDCEHLERLDCSGNLdlmdlpfE 217
Cdd:COG4886   36 ALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------E 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 218 LSNLKQVTFVDISANKFSSVPICVLRMCRLQWLDISSNNLSDLPQDIDRLEELQGFLLYKNKLTYLPQAMLNLKKLTLLV 297
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELD 188

                        170       180       190
                 ....*....|....*....|....*....|
gi 568964344 298 VSGDHLVEVPTALCDASTpLKFVSLVDNPI 327
Cdd:COG4886  189 LSNNQITDLPEPLGNLTN-LEELDLSGNQL 217
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 140-296 6.03e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 76.43  E-value: 6.03e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 140 LIQIIPTYIELFQAMKILDLPKNQITC-LPAEIGRLKNLKELNVSFNHLK-SIPPELGDCEHLERLDCSGNLDLMDLPFE 217
Cdd:PLN00113 176 LVGKIPNSLTNLTSLEFLTLASNQLVGqIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTGPIPSS 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 218 LSNLKQVTFVDISANKFS-SVPICVLRMCRLQWLDISSNNLS-DLPQDIDRLEELQGFLLYKNKLT-YLPQAMLNLKKLT 294
Cdd:PLN00113 256 LGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQ 335


                 ..
gi 568964344 295 LL 296
Cdd:PLN00113 336 VL 337
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 144-322 1.89e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.64  E-value: 1.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 144 IPTYIELFQAMKILDLPKNQITC-LPAEIGRLKNLKELNVSFNHLK-------------------------SIPPELGDC 197
Cdd:PLN00113 324 IPVALTSLPRLQVLQLWSNKFSGeIPKNLGKHNNLTVLDLSTNNLTgeipeglcssgnlfklilfsnslegEIPKSLGAC 403

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 198 EHLERLDCSGNLDLMDLPFELSNLKQVTFVDISANKFS-SVPICVLRMCRLQWLDISSNNLS-DLPQDI--DRLEELQgf 273
Cdd:PLN00113 404 RSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKFFgGLPDSFgsKRLENLD-- 481

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568964344 274 lLYKNKLT-YLPQAMLNLKKLTLLVVSGDHLV-EVPTALcdaSTPLKFVSL 322
Cdd:PLN00113 482 -LSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDEL---SSCKKLVSL 528
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
144-327 3.07e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 65.10  E-value: 3.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 144 IPTYIElfQAMKILDLPKNQITCLPAEIGrlKNLKELNVSFNHLKSIPPELGDCehLERLDCSGNlDLMDLPFELSNLKQ 223
Cdd:PRK15370 193 IPACIP--EQITTLILDNNELKSLPENLQ--GNIKTLYANSNQLTSIPATLPDT--IQEMELSIN-RITELPERLPSALQ 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 224 VtfVDISANKFSSVPICVLRmcRLQWLDISSNNLSDLPQDIDrlEELQGFLLYKNKLTYLPQAM-LNLKKLtllvVSGDH 302
Cdd:PRK15370 266 S--LDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETLpPGLKTL----EAGEN 335

                        170       180
                 ....*....|....*....|....*.
gi 568964344 303 -LVEVPTALCDAstpLKFVSLVDNPI 327
Cdd:PRK15370 336 aLTSLPASLPPE---LQVLDVSKNQI 358
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 120-325 4.09e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.48  E-value: 4.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 120 ELPDSLKEQTHLKEWYI-HSTLIQIIPTYIELFQAMKILDLPKNQITC-LPAEIGRLKNLKELNVSFNHLK-SIPPELGD 196
Cdd:PLN00113 203 QIPRELGQMKSLKWIYLgYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGpIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFS 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 197 CEHLERLDCSGNLDLMDLPFELSNLKQVTFVDISANKFS-SVPICVLRMCRLQWLDISSNNLS-DLPQDIDRLEELQGFL 274
Cdd:PLN00113 283 LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLD 362

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568964344 275 LYKNKLT-YLPQAMLNLKKLTLLVVSGDHLV-EVPTALCDASTpLKFVSLVDN 325
Cdd:PLN00113 363 LSTNNLTgEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRS-LRRVRLQDN 414
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 153-307 3.68e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.79  E-value: 3.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 153 AMKILDLPKNQITClPAEIGRLKNLKELNVSFNHLK-SIPPELGDCEHLERLDCSGNLDLMDLPFELSNLKQVTFVDISA 231
Cdd:PLN00113 119 SLRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLAS 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 232 NKFS-SVPICVLRMCRLQWLDISSNNLS----------------DL---------PQDIDRLEELQGFLLYKNKLT-YLP 284
Cdd:PLN00113 198 NQLVgQIPRELGQMKSLKWIYLGYNNLSgeipyeiggltslnhlDLvynnltgpiPSSLGNLKNLQYLFLYQNKLSgPIP 277

                        170       180
                 ....*....|....*....|....
gi 568964344 285 QAMLNLKKLTLLVVSGDHLV-EVP 307
Cdd:PLN00113 278 PSIFSLQKLISLDLSDNSLSgEIP 301
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 153-270 1.87e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.39  E-value: 1.87e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 153 AMKILDLPKNQITCLPAEIGRLKNLKELNVSFNHLK-SIPPELGDCEHLERLDCSGNLDLMDLPFELSNLKQVTFVDISA 231
Cdd:PLN00113 453 SLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSH 532

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568964344 232 NKFS-SVPICVLRMCRLQWLDISSNNLS-DLPQDIDRLEEL 270
Cdd:PLN00113 533 NQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
162-305 2.40e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 52.86  E-value: 2.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 162 NQITCLPAeigRLKNLKELNVSFNHLKSIPPELGDCEHLerldCSGNLDLMDLPFELSNLKQVTfvdISANKFSSVPICV 241
Cdd:PRK15387 332 NQLTSLPT---LPSGLQELSVSDNQLASLPTLPSELYKL----WAYNNRLTSLPALPSGLKELI---VSGNRLTSLPVLP 401

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568964344 242 lrmCRLQWLDISSNNLSDLPQDIDRLEELQgflLYKNKLTYLPQAMLNLKKLTLLVVSGDHLVE 305
Cdd:PRK15387 402 ---SELKELMVSGNRLTSLPMLPSGLLSLS---VYRNQLTRLPESLIHLSSETTVNLEGNPLSE 459
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
110-287 1.88e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.08  E-value: 1.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 110 VFELSGTQWKELPDSLKeqTHLKEWYIHSTLIQIIPTyiELFQAMKILDLPKNQITCLPAEIGrlKNLKELNVSFNHLKS 189
Cdd:PRK15370 245 EMELSINRITELPERLP--SALQSLDLFHNKISCLPE--NLPEELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTA 318

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 190 IPPELGdcEHLERLDCSGNLdLMDLPFELSNLKQVtfVDISANKFSSVPICVLRMcrLQWLDISSNNLSDLPQDIDrlEE 269
Cdd:PRK15370 319 LPETLP--PGLKTLEAGENA-LTSLPASLPPELQV--LDVSKNQITVLPETLPPT--ITTLDVSRNALTNLPENLP--AA 389

                        170
                 ....*....|....*...
gi 568964344 270 LQGFLLYKNKLTYLPQAM 287
Cdd:PRK15370 390 LQIMQASRNNLVRLPESL 407
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
138-307 3.37e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 49.01  E-value: 3.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 138 STLIQIIPTYIelfqamKILDLPKNQITCLPAEIGRLKNLKELNVSFNHLKSIPPELGDCE-------HLERLDCS---- 206
Cdd:PRK15387 214 TTLPDCLPAHI------TTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLPPGLLELSifsnpltHLPALPSGlckl 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 207 ---GNlDLMDLPFELSNLKQVTfvdISANKFSSVPICVLRMCR-----------------LQWLDISSNNLSDLPQdidR 266
Cdd:PRK15387 288 wifGN-QLTSLPVLPPGLQELS---VSDNQLASLPALPSELCKlwaynnqltslptlpsgLQELSVSDNQLASLPT---L 360

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 568964344 267 LEELQGFLLYKNKLTYLPQAMLNLKKltlLVVSGDHLVEVP 307
Cdd:PRK15387 361 PSELYKLWAYNNRLTSLPALPSGLKE---LIVSGNRLTSLP 398
LRR_8 pfam13855
Leucine rich repeat;
246-303 5.88e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 5.88e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344  246 RLQWLDISSNNLSDLPQDI-DRLEELQGFLLYKNKLTYL-PQAMLNLKKLTLLVVSGDHL 303
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 175-216 2.88e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.08  E-value: 2.88e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568964344  175 KNLKELNVSFNHLKSIPPeLGDCEHLERLDCSGNLDLMDLPF 216
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP-LAKLPNLETLDLSGNNKITDLSD 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 155-208 7.25e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 7.25e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568964344 155 KILDLPKNQITCLpAEIGRLKNLKELNVSFNHLKSIP---PELGDCEHLERLDCSGN 208
Cdd:cd21340  123 RVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
155-209 8.76e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 8.76e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568964344  155 KILDLPKNQITCLPAEI-GRLKNLKELNVSFNHLKSIPPE-LGDCEHLERLDCSGNL 209
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
176-257 1.92e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344  176 NLKELNVSFNHLKSIPPE-LGDCEHLERLDCSGNLdlmdlpfeLSNLKQVTFVDISAnkfssvpicvlrmcrLQWLDISS 254
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNL--------LTTLSPGAFSGLPS---------------LRYLDLSG 58


                  ...
gi 568964344  255 NNL 257
Cdd:pfam13855  59 NRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 157-295 8.42e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 8.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 157 LDLPKNQITCLPaEIGRLKNLKELNVSFNHLKSIppE-LGDCEHLERLDCSG-NLD----LMDLPFELSNL-KQVTFVDI 229
Cdd:cd21340   51 LYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV--EgLENLTNLEELHIENqRLPpgekLTFDPRSLAALsNSLRVLNI 127

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568964344 230 SANKFSSV-PICVLRmcRLQWLDISSNNLSDlpqdidrLEELQGFLlyknkltylpQAMLNLKKLTL 295
Cdd:cd21340  128 SGNNIDSLePLAPLR--NLEQLDASNNQISD-------LEELLDLL----------SSWPSLRELDL 175
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 112-254 1.60e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568964344 112 ELSGtqwkELPDSLKEQTHLKEWYI-HSTLIQIIPTYIELFQAMKILDLPKNQITC-LPAEIGRLKNLKELNVSFNHLKS 189
Cdd:PLN00113 510 KLSG----EIPDELSSCKKLVSLDLsHNQLSGQIPASFSEMPVLSQLDLSQNQLSGeIPKNLGNVESLVQVNISHNHLHG 585

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568964344 190 IPPELGDCEHLERLDCSGNLDLmdlpfelsnlkqvtfvdISANKFSSVPIC-VLRMCRLQWLDISS 254
Cdd:PLN00113 586 SLPSTGAFLAINASAVAGNIDL-----------------CGGDTTSGLPPCkRVRKTPSWWFYITC 634
LRR smart00370
Leucine-rich repeats, outliers;
174-197 5.13e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 5.13e-03
                           10        20
                   ....*....|....*....|....
gi 568964344   174 LKNLKELNVSFNHLKSIPPELGDC 197
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
174-197 5.13e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 5.13e-03
                           10        20
                   ....*....|....*....|....
gi 568964344   174 LKNLKELNVSFNHLKSIPPELGDC 197
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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