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Conserved domains on  [gi|568962150|ref|XP_006511545|]
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uveal autoantigen with coiled-coil domains and ankyrin repeats isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-249 3.14e-41

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 153.96  E-value: 3.14e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   19 NKYDDRLMKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKY 98
Cdd:COG0666    51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   99 GHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGA 178
Cdd:COG0666   131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568962150  179 DVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLLKTASENTNKG 249
Cdd:COG0666   211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAA 281
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 472-1295 1.29e-23

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 108.99  E-value: 1.29e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   472 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQtHFLALKEHLTNEAATGS-------HRIIEELREQLKDLKGK 544
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSLERQAEKAE-RYKELKAELRELELALLvlrleelREELEELQEELKEAEEE 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   545 YEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptEKF 624
Cdd:TIGR02168  255 LEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQL------EEL 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   625 ESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDL-ESVRAQHIRPEEHEQLRSR---LEQKSGELGKKVSELTLK 700
Cdd:TIGR02168  329 ESKLDELAEELAELEEKLEELKEELESLEAELEELEAELeELESRLEELEEQLETLRSKvaqLELQIASLNNEIERLEAR 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   701 NQTLQKDVEKLHADNKLLNQQVHSLtvEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEaerLLAENDK 780
Cdd:TIGR02168  409 LERLEDRRERLQQEIEELLKKLEEA--ELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQA---LDAAERE 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   781 LTKNVSRLEAVfvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRA-------------------LMSENSSLK 841
Cdd:TIGR02168  484 LAQLQARLDSL----ERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVdegyeaaieaalggrlqavVVENLNAAK 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   842 KTLSSQyvpaKTHEEVKAS---LNSTVEKTNRA-LLEAKKRFDDTSQEVSKLRDENEVLRRNLE---------------- 901
Cdd:TIGR02168  560 KAIAFL----KQNELGRVTflpLDSIKGTEIQGnDREILKNIEGFLGVAKDLVKFDPKLRKALSyllggvlvvddldnal 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   902 NVQNQMKADY--VSLEEH-------------SRRMSTVSQSlKEAQEANAAIladhRQGQEEIVSLHAEIKAQKKELDTI 966
Cdd:TIGR02168  636 ELAKKLRPGYriVTLDGDlvrpggvitggsaKTNSSILERR-REIEELEEKI----EELEEKIAELEKALAELRKELEEL 710

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   967 QECIKLKyapLARLEECERKFKAtekgLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREA 1046
Cdd:TIGR02168  711 EEELEQL---RKELEELSRQISA----LRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAE 783

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1047 ERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS 1126
Cdd:TIGR02168  784 IEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEE 863

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1127 KQRCLEREQqtvSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKN 1206
Cdd:TIGR02168  864 LEELIEELE---SELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1207 LETR----EVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQ-------ACEEkvsAKDEKELLhlsieQEIRDQKERC 1275
Cdd:TIGR02168  941 LQERlseeYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKElgpvnlaAIEE---YEELKERY-----DFLTAQKEDL 1012

                          890       900
                   ....*....|....*....|
gi 568962150  1276 DKSLTTIMELQQRIQESAKQ 1295
Cdd:TIGR02168 1013 TEAKETLEEAIEEIDREARE 1032
SMC_N super family cl47134
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 280-605 6.50e-03

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


The actual alignment was detected with superfamily member TIGR02169:

Pssm-ID: 481474 [Multi-domain]  Cd Length: 1164  Bit Score: 41.21  E-value: 6.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   280 REQREPHSFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIE 359
Cdd:TIGR02169  675 ELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIE 754

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   360 ALKNRFKYFESDHPgpgsypsnRKEDMLHKqgqmyttepqcaspgipphmhsrsmlrpLELSLPSqtsySENEILKKELE 439
Cdd:TIGR02169  755 NVKSELKELEARIE--------ELEEDLHK----------------------------LEEALND----LEARLSHSRIP 794

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   440 TLRTYYDSAKQDRLKFQNELAHKVAECKALALE---CERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQthflalk 516
Cdd:TIGR02169  795 EIQAELSKLEEEVSRIEARLREIEQKLNRLTLEkeyLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELE------- 867

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   517 ehltneaatgshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELER 596
Cdd:TIGR02169  868 ------------EELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSE 935


                   ....*....
gi 568962150   597 RGRRVVELE 605
Cdd:TIGR02169  936 IEDPKGEDE 944
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-249 3.14e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 153.96  E-value: 3.14e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   19 NKYDDRLMKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKY 98
Cdd:COG0666    51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   99 GHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGA 178
Cdd:COG0666   131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568962150  179 DVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLLKTASENTNKG 249
Cdd:COG0666   211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAA 281
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 472-1295 1.29e-23

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 108.99  E-value: 1.29e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   472 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQtHFLALKEHLTNEAATGS-------HRIIEELREQLKDLKGK 544
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSLERQAEKAE-RYKELKAELRELELALLvlrleelREELEELQEELKEAEEE 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   545 YEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptEKF 624
Cdd:TIGR02168  255 LEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQL------EEL 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   625 ESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDL-ESVRAQHIRPEEHEQLRSR---LEQKSGELGKKVSELTLK 700
Cdd:TIGR02168  329 ESKLDELAEELAELEEKLEELKEELESLEAELEELEAELeELESRLEELEEQLETLRSKvaqLELQIASLNNEIERLEAR 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   701 NQTLQKDVEKLHADNKLLNQQVHSLtvEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEaerLLAENDK 780
Cdd:TIGR02168  409 LERLEDRRERLQQEIEELLKKLEEA--ELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQA---LDAAERE 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   781 LTKNVSRLEAVfvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRA-------------------LMSENSSLK 841
Cdd:TIGR02168  484 LAQLQARLDSL----ERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVdegyeaaieaalggrlqavVVENLNAAK 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   842 KTLSSQyvpaKTHEEVKAS---LNSTVEKTNRA-LLEAKKRFDDTSQEVSKLRDENEVLRRNLE---------------- 901
Cdd:TIGR02168  560 KAIAFL----KQNELGRVTflpLDSIKGTEIQGnDREILKNIEGFLGVAKDLVKFDPKLRKALSyllggvlvvddldnal 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   902 NVQNQMKADY--VSLEEH-------------SRRMSTVSQSlKEAQEANAAIladhRQGQEEIVSLHAEIKAQKKELDTI 966
Cdd:TIGR02168  636 ELAKKLRPGYriVTLDGDlvrpggvitggsaKTNSSILERR-REIEELEEKI----EELEEKIAELEKALAELRKELEEL 710

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   967 QECIKLKyapLARLEECERKFKAtekgLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREA 1046
Cdd:TIGR02168  711 EEELEQL---RKELEELSRQISA----LRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAE 783

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1047 ERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS 1126
Cdd:TIGR02168  784 IEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEE 863

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1127 KQRCLEREQqtvSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKN 1206
Cdd:TIGR02168  864 LEELIEELE---SELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1207 LETR----EVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQ-------ACEEkvsAKDEKELLhlsieQEIRDQKERC 1275
Cdd:TIGR02168  941 LQERlseeYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKElgpvnlaAIEE---YEELKERY-----DFLTAQKEDL 1012

                          890       900
                   ....*....|....*....|
gi 568962150  1276 DKSLTTIMELQQRIQESAKQ 1295
Cdd:TIGR02168 1013 TEAKETLEEAIEEIDREARE 1032
Ank_2 pfam12796
Ankyrin repeats (3 copies);
92-184 3.68e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 83.63  E-value: 3.68e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150    92 LHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHgASVNAKDiDGRTPLVLATQMCRPTICQ 171
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 568962150   172 LLIDRGADVNSRD 184
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 35-203 9.44e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 91.24  E-value: 9.44e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   35 EKVSSILAKKGVHPGKLDVEGRSAFHV-VASKG-NLECLNAILTHGIDVATRDSAGRNALHLAAKYGH--ALCLQKLLQY 110
Cdd:PHA03095  132 PKVIRLLLRKGADVNALDLYGMTPLAVlLKSRNaNVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKprARIVRELIRA 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  111 NCPTEHVDLQGRTALHDAAM-ADCPSS-IQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNR 188
Cdd:PHA03095  212 GCDPAATDMLGNTPLHSMATgSSCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291

                         170
                  ....*....|....*
gi 568962150  189 TALMLGCEYGCRDAV 203
Cdd:PHA03095  292 TPLSLMVRNNNGRAV 306
PTZ00121 PTZ00121
MAEBL; Provisional
 445-1268 2.65e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 91.74  E-value: 2.65e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  445 YDSAKQDRLKFQNELAHKVAEcKALALECERVKEDS--DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNE 522
Cdd:PTZ00121 1081 FDAKEDNRADEATEEAFGKAE-EAKKTETGKAEEARkaEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARK 1159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  523 AATGshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKR--DEGRLVEENKRLQKECGTCEVELERRGRR 600
Cdd:PTZ00121 1160 AEDA--RKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARkaEEERKAEEARKAEDAKKAEAVKKAEEAKK 1237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  601 VVELEGQLKELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYEsaqgeirQLKRDLESVRAQHIRPEEHEQLR 680
Cdd:PTZ00121 1238 DAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAE-------EKKKADEAKKAEEKKKADEAKKK 1310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  681 SRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQqvhsltvEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEA 760
Cdd:PTZ00121 1311 AEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKA-------EAEAAADEAEAAEEKAEAAEKKKEEAKKKADAA 1383

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  761 TQRYTEKKQ--EAERLLAENDKLTKNVSRLEAVFVAPEKHEKElmglksniAELKKQLSELNKKcGEGQEKIRALMSENS 838
Cdd:PTZ00121 1384 KKKAEEKKKadEAKKKAEEDKKKADELKKAAAAKKKADEAKKK--------AEEKKKADEAKKK-AEEAKKADEAKKKAE 1454

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  839 SLKKtlsSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRR--NLENVQNQMKADYVSLEE 916
Cdd:PTZ00121 1455 EAKK---AEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKadEAKKAEEAKKADEAKKAE 1531

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  917 HSRRMSTVSQSlKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKE 996
Cdd:PTZ00121 1532 EAKKADEAKKA-EEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAE 1610

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  997 QLsEQTHKCRQRDEEVKKGKQEnerlRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSERE 1076
Cdd:PTZ00121 1611 EA-KKAEEAKIKAEELKKAEEE----KKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEE 1685

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1077 ---KLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKS---LNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKN 1150
Cdd:PTZ00121 1686 dekKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAeeeNKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKE 1765

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1151 SSVTLAEHLKLKEA-LEKEVGIMKASLREKEEESQKKTKEVSKL----------------QTEVQTTKQAL--KNLETRE 1211
Cdd:PTZ00121 1766 EEKKAEEIRKEKEAvIEEELDEEDEKRRMEVDKKIKDIFDNFANiieggkegnlvindskEMEDSAIKEVAdsKNMQLEE 1845

                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568962150 1212 VVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEI 1268
Cdd:PTZ00121 1846 ADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREI 1902
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 474-1301 7.42e-14

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 77.08  E-value: 7.42e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   474 ERVKEDSDEQIKQLEDALKD-----------VQKRMYESEGKVKQMQTHFLALKEHLTNEAATGshriiEELREQLKDLK 542
Cdd:pfam15921   77 ERVLEEYSHQVKDLQRRLNEsnelhekqkfyLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQ-----EDLRNQLQNTV 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   543 GKYEGA-SAEVGKLRSQIKQSEMLVGEFKRDEGRLveenkrlqKECGTCEVELER-RGRRVVELEgqlkelgaklalSVP 620
Cdd:pfam15921  152 HELEAAkCLKEDMLEDSNTQIEQLRKMMLSHEGVL--------QEIRSILVDFEEaSGKKIYEHD------------SMS 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   621 TEKFESMKSSLSndinekvKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEH--EQLRSRLEQKSGELGKKVSELT 698
Cdd:pfam15921  212 TMHFRSLGSAIS-------KILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELllQQHQDRIEQLISEHEVEITGLT 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   699 LKNQTLQKDVEKLHADNKLLNQQVHSLTV-------EMKTRYVPLRVS-EEMKKSHDVNVEDLNKKLSEATQRYTEKKQE 770
Cdd:pfam15921  285 EKASSARSQANSIQSQLEIIQEQARNQNSmymrqlsDLESTVSQLRSElREAKRMYEDKIEELEKQLVLANSELTEARTE 364

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   771 AERLLAENDKLTKNVSRLEAVFvapEKHEKELmglksniaELKKqlsELNKKCGEGQEKIRALMSEnssLKKTLSSQYVP 850
Cdd:pfam15921  365 RDQFSQESGNLDDQLQKLLADL---HKREKEL--------SLEK---EQNKRLWDRDTGNSITIDH---LRRELDDRNME 427

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   851 AKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKE 930
Cdd:pfam15921  428 VQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQE 507

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   931 AQEANAAILAdhrqgqeEIVSLHAEIKAQKKELDTIQ-ECIKLKYAPlarlEECER-KFKATEKG-LKEQLSEQTHKCRQ 1007
Cdd:pfam15921  508 KERAIEATNA-------EITKLRSRVDLKLQELQHLKnEGDHLRNVQ----TECEAlKLQMAEKDkVIEILRQQIENMTQ 576

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1008 RdeeVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLS--------------QKYSDVKS 1073
Cdd:pfam15921  577 L---VGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLElekvklvnagserlRAVKDIKQ 653

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1074 EREKLVEEKAKQASEIlaaQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSV 1153
Cdd:pfam15921  654 ERDQLLNEVKTSRNEL---NSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAM 730

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1154 TLAEHLKLK----EALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTkqalknletreVVDMSKYKATKNDLETQI 1229
Cdd:pfam15921  731 GMQKQITAKrgqiDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTV-----------ATEKNKMAGELEVLRSQE 799

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568962150  1230 SNLNDKLASLNRKYDQACEEKVSAKD-----EKELLHLSIEQEIrDQKERCDKSLTTIMELQQRIQESAKQIEAKDN 1301
Cdd:pfam15921  800 RRLKEKVANMEVALDKASLQFAECQDiiqrqEQESVRLKLQHTL-DVKELQGPGYTSNSSMKPRLLQPASFTRTHSN 875
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1053-1396 1.99e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 72.28  E-value: 1.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1053 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQpvpLEQVEALKKSLNGTIEQLKEELRSKQRCLE 1132
Cdd:COG1196   233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEEL---ELELEEAQAEEYELLAELARLEQDIARLEE 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1133 REQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEE---ESQKKTKEVSKLQTEVQTTKQALKNLET 1209
Cdd:COG1196   310 RRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAelaEAEEALLEAEAELAEAEEELEELAEELL 389

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1210 REVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERcdksLTTIMELQQRI 1289
Cdd:COG1196   390 EALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL----EEEEEALLELL 465

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1290 QESAKQIEAKDNKITELLNDVERLKQALNGLSQLTyssgspTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYRTH 1369
Cdd:COG1196   466 AELLEEAALLEAALAELLEELAEAAARLLLLLEAE------ADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAA 539

                         330       340
                  ....*....|....*....|....*..
gi 568962150 1370 LLSAAQGHMDEDVQAALLQIIQMRQGL 1396
Cdd:COG1196   540 LEAALAAALQNIVVEDDEVAAAAIEYL 566
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 15-221 3.94e-07

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 54.70  E-value: 3.94e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150    15 SAEWNKYDDRLMKAAERGDVEKVSsilaKKGVHPGKLDVE-----GRSAFHVVASKGNLECLNAIL-THGIDVATrdsaG 88
Cdd:TIGR00870   11 ESPLSDEEKAFLPAAERGDLASVY----RDLEEPKKLNINcpdrlGRSALFVAAIENENLELTELLlNLSCRGAV----G 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150    89 RNALHLAAKYGHA---LCLQKLLQ---YNCPTEHVDLQ-------GRTALHDAAMADCPSSIQLLCDHGASVNAK----- 150
Cdd:TIGR00870   83 DTLLHAISLEYVDaveAILLHLLAafrKSGPLELANDQytseftpGITALHLAAHRQNYEIVKLLLERGASVPARacgdf 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   151 -----DID----GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALML-------GCEY----------------G 198
Cdd:TIGR00870  163 fvksqGVDsfyhGESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLlvmenefKAEYeelscqmynfalslldK 242

                          250       260
                   ....*....|....*....|....
gi 568962150   199 CRDAVEV-LVKNGADLTLLDALGH 221
Cdd:TIGR00870  243 LRDSKELeVILNHQGLTPLKLAAK 266
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 63-191 4.76e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.25  E-value: 4.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   63 ASKGNLECLNAILT-HGIDVATRDSAGRNALHLAAKYGHALCLQKLLqyNCPTEHVDL-------QGRTALHDAAMADCP 134
Cdd:cd22192    25 AKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLM--EAAPELVNEpmtsdlyQGETALHIAVVNQNL 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568962150  135 SSIQLLCDHGASVNA---------KDID-----GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTAL 191
Cdd:cd22192   103 NLVRELIARGADVVSpratgtffrPGPKnliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 280-605 6.50e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.21  E-value: 6.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   280 REQREPHSFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIE 359
Cdd:TIGR02169  675 ELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIE 754

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   360 ALKNRFKYFESDHPgpgsypsnRKEDMLHKqgqmyttepqcaspgipphmhsrsmlrpLELSLPSqtsySENEILKKELE 439
Cdd:TIGR02169  755 NVKSELKELEARIE--------ELEEDLHK----------------------------LEEALND----LEARLSHSRIP 794

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   440 TLRTYYDSAKQDRLKFQNELAHKVAECKALALE---CERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQthflalk 516
Cdd:TIGR02169  795 EIQAELSKLEEEVSRIEARLREIEQKLNRLTLEkeyLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELE------- 867

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   517 ehltneaatgshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELER 596
Cdd:TIGR02169  868 ------------EELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSE 935


                   ....*....
gi 568962150   597 RGRRVVELE 605
Cdd:TIGR02169  936 IEDPKGEDE 944
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
19-249 3.14e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 153.96  E-value: 3.14e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   19 NKYDDRLMKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKY 98
Cdd:COG0666    51 DALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   99 GHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGA 178
Cdd:COG0666   131 GNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA 210

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568962150  179 DVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLLKTASENTNKG 249
Cdd:COG0666   211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAA 281
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
16-248 6.59e-40

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 150.10  E-value: 6.59e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   16 AEWNKYDDRLMKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLA 95
Cdd:COG0666    15 LLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   96 AKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLID 175
Cdd:COG0666    95 ARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE 174

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568962150  176 RGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLLKTASENTNK 248
Cdd:COG0666   175 AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNA 247
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
25-222 1.30e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.92  E-value: 1.30e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   25 LMKAAERGDVEKVSsILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCL 104
Cdd:COG0666    91 LHAAARNGDLEIVK-LLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIV 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  105 QKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRD 184
Cdd:COG0666   170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKD 249

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 568962150  185 KQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHD 222
Cdd:COG0666   250 KDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
40-239 9.71e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 123.53  E-value: 9.71e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   40 ILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDL 119
Cdd:COG0666     6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  120 QGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGC 199
Cdd:COG0666    86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 568962150  200 RDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLL 239
Cdd:COG0666   166 LEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 472-1295 1.29e-23

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 108.99  E-value: 1.29e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   472 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQtHFLALKEHLTNEAATGS-------HRIIEELREQLKDLKGK 544
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLKSLERQAEKAE-RYKELKAELRELELALLvlrleelREELEELQEELKEAEEE 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   545 YEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptEKF 624
Cdd:TIGR02168  255 LEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQL------EEL 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   625 ESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDL-ESVRAQHIRPEEHEQLRSR---LEQKSGELGKKVSELTLK 700
Cdd:TIGR02168  329 ESKLDELAEELAELEEKLEELKEELESLEAELEELEAELeELESRLEELEEQLETLRSKvaqLELQIASLNNEIERLEAR 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   701 NQTLQKDVEKLHADNKLLNQQVHSLtvEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEaerLLAENDK 780
Cdd:TIGR02168  409 LERLEDRRERLQQEIEELLKKLEEA--ELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQA---LDAAERE 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   781 LTKNVSRLEAVfvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRA-------------------LMSENSSLK 841
Cdd:TIGR02168  484 LAQLQARLDSL----ERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVdegyeaaieaalggrlqavVVENLNAAK 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   842 KTLSSQyvpaKTHEEVKAS---LNSTVEKTNRA-LLEAKKRFDDTSQEVSKLRDENEVLRRNLE---------------- 901
Cdd:TIGR02168  560 KAIAFL----KQNELGRVTflpLDSIKGTEIQGnDREILKNIEGFLGVAKDLVKFDPKLRKALSyllggvlvvddldnal 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   902 NVQNQMKADY--VSLEEH-------------SRRMSTVSQSlKEAQEANAAIladhRQGQEEIVSLHAEIKAQKKELDTI 966
Cdd:TIGR02168  636 ELAKKLRPGYriVTLDGDlvrpggvitggsaKTNSSILERR-REIEELEEKI----EELEEKIAELEKALAELRKELEEL 710

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   967 QECIKLKyapLARLEECERKFKAtekgLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREA 1046
Cdd:TIGR02168  711 EEELEQL---RKELEELSRQISA----LRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAE 783

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1047 ERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS 1126
Cdd:TIGR02168  784 IEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEE 863

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1127 KQRCLEREQqtvSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKN 1206
Cdd:TIGR02168  864 LEELIEELE---SELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1207 LETR----EVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQ-------ACEEkvsAKDEKELLhlsieQEIRDQKERC 1275
Cdd:TIGR02168  941 LQERlseeYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKElgpvnlaAIEE---YEELKERY-----DFLTAQKEDL 1012

                          890       900
                   ....*....|....*....|
gi 568962150  1276 DKSLTTIMELQQRIQESAKQ 1295
Cdd:TIGR02168 1013 TEAKETLEEAIEEIDREARE 1032
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
25-191 1.69e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 99.26  E-value: 1.69e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   25 LMKAAERGDVEKVSsILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCL 104
Cdd:COG0666   124 LHLAAYNGNLEIVK-LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  105 QKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRD 184
Cdd:COG0666   203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282


                  ....*..
gi 568962150  185 KQNRTAL 191
Cdd:COG0666   283 LDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
71-239 3.15e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 89.63  E-value: 3.15e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   71 LNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAK 150
Cdd:COG0666     4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  151 DIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIG 230
Cdd:COG0666    84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163


                  ....*....
gi 568962150  231 DNLDILNLL 239
Cdd:COG0666   164 GNLEIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
92-184 3.68e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 83.63  E-value: 3.68e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150    92 LHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHgASVNAKDiDGRTPLVLATQMCRPTICQ 171
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 568962150   172 LLIDRGADVNSRD 184
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 35-203 9.44e-19

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 91.24  E-value: 9.44e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   35 EKVSSILAKKGVHPGKLDVEGRSAFHV-VASKG-NLECLNAILTHGIDVATRDSAGRNALHLAAKYGH--ALCLQKLLQY 110
Cdd:PHA03095  132 PKVIRLLLRKGADVNALDLYGMTPLAVlLKSRNaNVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKprARIVRELIRA 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  111 NCPTEHVDLQGRTALHDAAM-ADCPSS-IQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNR 188
Cdd:PHA03095  212 GCDPAATDMLGNTPLHSMATgSSCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291

                         170
                  ....*....|....*
gi 568962150  189 TALMLGCEYGCRDAV 203
Cdd:PHA03095  292 TPLSLMVRNNNGRAV 306
Ank_2 pfam12796
Ankyrin repeats (3 copies);
59-151 2.55e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 81.32  E-value: 2.55e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150    59 FHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTehVDLQGRTALHDAAMADCPSSIQ 138
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN--LKDNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 568962150   139 LLCDHGASVNAKD 151
Cdd:pfam12796   79 LLLEKGADINVKD 91
PTZ00121 PTZ00121
MAEBL; Provisional
 445-1268 2.65e-18

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 91.74  E-value: 2.65e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  445 YDSAKQDRLKFQNELAHKVAEcKALALECERVKEDS--DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNE 522
Cdd:PTZ00121 1081 FDAKEDNRADEATEEAFGKAE-EAKKTETGKAEEARkaEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARK 1159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  523 AATGshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKR--DEGRLVEENKRLQKECGTCEVELERRGRR 600
Cdd:PTZ00121 1160 AEDA--RKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARkaEEERKAEEARKAEDAKKAEAVKKAEEAKK 1237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  601 VVELEGQLKELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYEsaqgeirQLKRDLESVRAQHIRPEEHEQLR 680
Cdd:PTZ00121 1238 DAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAE-------EKKKADEAKKAEEKKKADEAKKK 1310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  681 SRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQqvhsltvEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEA 760
Cdd:PTZ00121 1311 AEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKA-------EAEAAADEAEAAEEKAEAAEKKKEEAKKKADAA 1383

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  761 TQRYTEKKQ--EAERLLAENDKLTKNVSRLEAVFVAPEKHEKElmglksniAELKKQLSELNKKcGEGQEKIRALMSENS 838
Cdd:PTZ00121 1384 KKKAEEKKKadEAKKKAEEDKKKADELKKAAAAKKKADEAKKK--------AEEKKKADEAKKK-AEEAKKADEAKKKAE 1454

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  839 SLKKtlsSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRR--NLENVQNQMKADYVSLEE 916
Cdd:PTZ00121 1455 EAKK---AEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKadEAKKAEEAKKADEAKKAE 1531

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  917 HSRRMSTVSQSlKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKE 996
Cdd:PTZ00121 1532 EAKKADEAKKA-EEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAE 1610

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  997 QLsEQTHKCRQRDEEVKKGKQEnerlRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSERE 1076
Cdd:PTZ00121 1611 EA-KKAEEAKIKAEELKKAEEE----KKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEE 1685

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1077 ---KLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKS---LNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKN 1150
Cdd:PTZ00121 1686 dekKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAeeeNKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKE 1765

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1151 SSVTLAEHLKLKEA-LEKEVGIMKASLREKEEESQKKTKEVSKL----------------QTEVQTTKQAL--KNLETRE 1211
Cdd:PTZ00121 1766 EEKKAEEIRKEKEAvIEEELDEEDEKRRMEVDKKIKDIFDNFANiieggkegnlvindskEMEDSAIKEVAdsKNMQLEE 1845

                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568962150 1212 VVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEI 1268
Cdd:PTZ00121 1846 ADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKIDKDDIEREI 1902
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
622-1208 5.12e-18

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 90.12  E-value: 5.12e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  622 EKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVSELTLKN 701
Cdd:PRK03918  182 EKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKI 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  702 QTLQKDVEKLHADNKLLNQQVHSLtvemktryvplrvsEEMKKshdvnVEDLNKKLSEATQRYTEKKQEAERLLAendKL 781
Cdd:PRK03918  262 RELEERIEELKKEIEELEEKVKEL--------------KELKE-----KAEEYIKLSEFYEEYLDELREIEKRLS---RL 319

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  782 TKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELnKKCGEGQEKIRALMSENSSLKKTLSsqyvpaktheevkasl 861
Cdd:PRK03918  320 EEEINGIEERIKELEEKEERLEELKKKLKELEKRLEEL-EERHELYEEAKAKKEELERLKKRLT---------------- 382

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  862 NSTVEKTNRALLEAKKRFDDTSQEVSKLRDEnevlRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEAN-----A 936
Cdd:PRK03918  383 GLTPEKLEKELEELEKAKEEIEEEISKITAR----IGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHRKElleeyT 458

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  937 AILADHRQGQEEIVSLHAEIKAQKKELDTIQEciklKYAPLARLEECERKFKATEKGLKEQLSEqthKCRQRDEEVKKGK 1016
Cdd:PRK03918  459 AELKRIEKELKEIEEKERKLRKELRELEKVLK----KESELIKLKELAEQLKELEEKLKKYNLE---ELEKKAEEYEKLK 531

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1017 QENERLRADLAALQKELQDRNALAEEAREAERalsgKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLL 1096
Cdd:PRK03918  532 EKLIKLKGEIKSLKKELEKLEELKKKLAELEK----KLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEYLEL 607

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1097 QKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQqllenQKNSSVTLAEHLKLKEALEKEVGIMKASL 1176
Cdd:PRK03918  608 KDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELE-----KKYSEEEYEELREEYLELSRELAGLRAEL 682

                         570       580       590
                  ....*....|....*....|....*....|..
gi 568962150 1177 REKEEESQKKTKEVSKLQTEVQTTKQALKNLE 1208
Cdd:PRK03918  683 EELEKRREEIKKTLEKLKEELEEREKAKKELE 714
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 530-1352 4.79e-17

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 87.43  E-value: 4.79e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   530 IIEELREQLKDLKG------KYEGASAEVGKLRSQIKQSEMLVGEfkRDEGRLVEENKRLQKECGTCEVELERRGRRVVE 603
Cdd:TIGR02169  192 IIDEKRQQLERLRRerekaeRYQALLKEKREYEGYELLKEKEALE--RQKEAIERQLASLEEELEKLTEEISELEKRLEE 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   604 LEGQLKELGAKLalsvptekfesmKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEheqLRSRL 683
Cdd:TIGR02169  270 IEQLLEELNKKI------------KDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEA---EIDKL 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   684 EQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRvseemkkshdvnveDLNKKLSEATQR 763
Cdd:TIGR02169  335 LAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELK--------------DYREKLEKLKRE 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   764 YTEKKQEAERLLAENDKLTKNVSRLEAvfvapekhekELMGLKSNIAELKKQLSELnkkcgegQEKIRALMSENSSLKKT 843
Cdd:TIGR02169  401 INELKRELDRLQEELQRLSEELADLNA----------AIAGIEAKINELEEEKEDK-------ALEIKKQEWKLEQLAAD 463

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   844 LSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMkADYVSLEEH------ 917
Cdd:TIGR02169  464 LSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTV-AQLGSVGERyataie 542

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   918 ---SRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHaEIKAQKKELDTIQECIKLKYAplARLEECERKFKATEK-- 992
Cdd:TIGR02169  543 vaaGNRLNNVVVEDDAVAKEAIELLKRRKAGRATFLPLN-KMRDERRDLSILSEDGVIGFA--VDLVEFDPKYEPAFKyv 619

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   993 -----------------------GLKEQLSEQT-------HKCRQRDEEVKKGKQENERLRADLAALQKELQDrnalaee 1042
Cdd:TIGR02169  620 fgdtlvvedieaarrlmgkyrmvTLEGELFEKSgamtggsRAPRGGILFSRSEPAELQRLRERLEGLKRELSS------- 692

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1043 AREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKE 1122
Cdd:TIGR02169  693 LQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEE 772

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1123 ElrskqrcLEREQQTVSQLQQLLENQKnssvtLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQ 1202
Cdd:TIGR02169  773 D-------LHKLEEALNDLEARLSHSR-----IPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQE 840

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1203 ALKNLETRevvdmskykatKNDLETQISNLNDKLASLNRKYDQAceEKVSAKDEKELLHLSIEQEIRDQKERcdksltti 1282
Cdd:TIGR02169  841 QRIDLKEQ-----------IKSIEKEIENLNGKKEELEEELEEL--EAALRDLESRLGDLKKERDELEAQLR-------- 899

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1283 mELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTySSGSPTKRQSQLVDTLQQRVRDLQQQL 1352
Cdd:TIGR02169  900 -ELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPK-GEDEEIPEEELSLEDVQAELQRVEEEI 967
PTZ00121 PTZ00121
MAEBL; Provisional
 618-1315 1.04e-16

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 86.73  E-value: 1.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  618 SVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQ-----LKRDLESVRAQHIRPEEH----EQLRSRLEQKSG 688
Cdd:PTZ00121 1075 SYKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEEARkaeeaKKKAEDARKAEEARKAEDarkaEEARKAEDAKRV 1154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  689 ELGKKVSELTLKNQTLQ-KDVEKLHADNKL--------LNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSE 759
Cdd:PTZ00121 1155 EIARKAEDARKAEEARKaEDAKKAEAARKAeevrkaeeLRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEE 1234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  760 ATQRYTE-KKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKkcgeGQEKIRAlmsenS 838
Cdd:PTZ00121 1235 AKKDAEEaKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKK----AEEKKKA-----D 1305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  839 SLKKtlssqyvpaKTHEEVKA-SLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEH 917
Cdd:PTZ00121 1306 EAKK---------KAEEAKKAdEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEA 1376

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  918 SRRMSTVSQSLKEAQEANaailadhrqgqeeivslhaeiKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQ 997
Cdd:PTZ00121 1377 KKKADAAKKKAEEKKKAD---------------------EAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADE 1435

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  998 LSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREK 1077
Cdd:PTZ00121 1436 AKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEA 1515

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1078 LVEEKAKQASEILAAQNllQKQPVPLEQVEALKKSlngtieqlkEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAE 1157
Cdd:PTZ00121 1516 KKAEEAKKADEAKKAEE--AKKADEAKKAEEKKKA---------DELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAE 1584

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1158 HLKLKE--------ALEKEVGIMKASLREKEEESQKKTKEVSKlQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQI 1229
Cdd:PTZ00121 1585 EAKKAEearieevmKLYEEEKKMKAEEAKKAEEAKIKAEELKK-AEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKA 1663

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1230 SNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEqeirdQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLND 1309
Cdd:PTZ00121 1664 AEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAE-----EAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKE 1738


                  ....*.
gi 568962150 1310 VERLKQ 1315
Cdd:PTZ00121 1739 AEEDKK 1744
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 636-1353 1.09e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 86.26  E-value: 1.09e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   636 NEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQH----------------------IRPEEHEQLRSRLEQKSGELGKK 693
Cdd:TIGR02168  175 KETERKLERTRENLDRLEDILNELERQLKSLERQAekaerykelkaelrelelallvLRLEELREELEELQEELKEAEEE 254

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   694 VSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAER 773
Cdd:TIGR02168  255 LEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDE 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   774 LLAENDKLTKNVSRLEAVFVAP----EKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSS--- 846
Cdd:TIGR02168  335 LAEELAELEEKLEELKEELESLeaelEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERled 414

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   847 ---------QYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNL---ENVQNQMKADYVSL 914
Cdd:TIGR02168  415 rrerlqqeiEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALdaaERELAQLQARLDSL 494

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   915 EEHSRRMSTVSQSLKE--------------------------------------------AQEANAAI--LADHRQGQ-- 946
Cdd:TIGR02168  495 ERLQENLEGFSEGVKAllknqsglsgilgvlselisvdegyeaaieaalggrlqavvvenLNAAKKAIafLKQNELGRvt 574

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   947 --EEIVSLHAEIKAQKKELDTIQECIKlkyAPLARLEECERKFKATEKGL------KEQLSEQTHKCRQRDEEVKKGKQE 1018
Cdd:TIGR02168  575 flPLDSIKGTEIQGNDREILKNIEGFL---GVAKDLVKFDPKLRKALSYLlggvlvVDDLDNALELAKKLRPGYRIVTLD 651

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1019 NERLRADLAALQKE------LQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAA 1092
Cdd:TIGR02168  652 GDLVRPGGVITGGSaktnssILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISAL 731

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1093 QNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQ-------QTVSQLQQLLENQKNSSVTLAEHLKlkeAL 1165
Cdd:TIGR02168  732 RKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEeelaeaeAEIEELEAQIEQLKEELKALREALD---EL 808

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1166 EKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLEtrevVDMSKYKATKNDLETQISNLNDKLASLNRKYDQ 1245
Cdd:TIGR02168  809 RAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELS----EDIESLAAEIEELEELIEELESELEALLNERAS 884

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1246 ACEEKVSAKDEKELLhlsiEQEIRDQKERcdkslttIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTY 1325
Cdd:TIGR02168  885 LEEALALLRSELEEL----SEELRELESK-------RSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTL 953

                          810       820
                   ....*....|....*....|....*....
gi 568962150  1326 SSGSPTKRQSQL-VDTLQQRVRDLQQQLA 1353
Cdd:TIGR02168  954 EEAEALENKIEDdEEEARRRLKRLENKIK 982
Ank_2 pfam12796
Ankyrin repeats (3 copies);
125-217 1.29e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 76.31  E-value: 1.29e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   125 LHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRgADVNSRDkQNRTALMLGCEYGCRDAVE 204
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 568962150   205 VLVKNGADLTLLD 217
Cdd:pfam12796   79 LLLEKGADINVKD 91
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 758-1361 1.44e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 85.88  E-value: 1.44e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   758 SEATQRYTEKKQEAERLLAE--NDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMS 835
Cdd:TIGR02168  209 AEKAERYKELKAELRELELAllVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQK 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   836 ENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLE 915
Cdd:TIGR02168  289 ELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELE 368

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   916 EHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIK--LKYAPLARLEECERKFKATEKG 993
Cdd:TIGR02168  369 ELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEelLKKLEEAELKELQAELEELEEE 448

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   994 LKEQLSEQthkcRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKS 1073
Cdd:TIGR02168  449 LEELQEEL----ERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGV 524

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1074 EREKL-VEEKAKQASEILAAQNLLQ----KQPVPLEQVEALKKSLNG------------------TIEQLKEELRSKQRC 1130
Cdd:TIGR02168  525 LSELIsVDEGYEAAIEAALGGRLQAvvveNLNAAKKAIAFLKQNELGrvtflpldsikgteiqgnDREILKNIEGFLGVA 604

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1131 LEREQQT----------------VSQLQQLLENQKNSS-----VTLAEHL------KLKEALEKEVGIM--KASLREKEE 1181
Cdd:TIGR02168  605 KDLVKFDpklrkalsyllggvlvVDDLDNALELAKKLRpgyriVTLDGDLvrpggvITGGSAKTNSSILerRREIEELEE 684

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1182 ESQKKTKEVSKLQTEVQTTKQALKNLETrevvDMSKYKATKNDLETQISNLNDKLASLNRK-------YDQACEEKVSAK 1254
Cdd:TIGR02168  685 KIEELEEKIAELEKALAELRKELEELEE----ELEQLRKELEELSRQISALRKDLARLEAEveqleerIAQLSKELTELE 760

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1255 DEKELLHLSIEQEIRDQKERCDKslttIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQ 1334
Cdd:TIGR02168  761 AEIEELEERLEEAEEELAEAEAE----IEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAAT 836

                          650       660
                   ....*....|....*....|....*..
gi 568962150  1335 SQLVDTLQQRVRDLQQQLADADRQHQE 1361
Cdd:TIGR02168  837 ERRLEDLEEQIEELSEDIESLAAEIEE 863
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 472-1285 4.96e-16

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 83.96  E-value: 4.96e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   472 ECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTH------FLALKEHLTNEAATGSHRIIEELREQLKDLKGKY 545
Cdd:TIGR02169  167 EFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRRErekaerYQALLKEKREYEGYELLKEKEALERQKEAIERQL 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   546 EGASAEVGKLRSQIKQSEMLVGEF--------KRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLA- 616
Cdd:TIGR02169  247 ASLEEELEKLTEEISELEKRLEEIeqlleelnKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAk 326

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   617 LSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRP-EEHEQLRSRLEQksgeLGKKVS 695
Cdd:TIGR02169  327 LEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETrDELKDYREKLEK----LKREIN 402

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   696 ELTLKNQTLQKDVEKLHADNKLLNQQVHSLtvemktryvplrvsEEMKKSHDVNVEDLNKKLSEATQrytekkqEAERLL 775
Cdd:TIGR02169  403 ELKRELDRLQEELQRLSEELADLNAAIAGI--------------EAKINELEEEKEDKALEIKKQEW-------KLEQLA 461

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   776 AENDKLTKNVSRLEAVFvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSS------QYV 849
Cdd:TIGR02169  462 ADLSKYEQELYDLKEEY---DRVEKELSKLQRELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQlgsvgeRYA 538

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   850 PAKtheEVKAS--LNSTVEKTNR------ALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRrm 921
Cdd:TIGR02169  539 TAI---EVAAGnrLNNVVVEDDAvakeaiELLKRRKAGRATFLPLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKYE-- 613

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   922 STVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQ 1001
Cdd:TIGR02169  614 PAFKYVFGDTLVVEDIEAARRLMGKYRMVTLEGELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSL 693

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1002 THKCRQRDEEVKKGKQENERLRADLAALQKELQdrnalaeEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEE 1081
Cdd:TIGR02169  694 QSELRRIENRLDELSQELSDASRKIGEIEKEIE-------QLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEAR 766

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1082 KAKQASEILAAQNLLQK-----QPVPLEQVEALKKSLNGTIEQLKEELRSkqrcLEREQQTVSQLQQLLENQKNSSVTLA 1156
Cdd:TIGR02169  767 IEELEEDLHKLEEALNDlearlSHSRIPEIQAELSKLEEEVSRIEARLRE----IEQKLNRLTLEKEYLEKEIQELQEQR 842

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1157 EHLKL-KEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETrevvDMSKYKATKNDLETQISNLNDK 1235
Cdd:TIGR02169  843 IDLKEqIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEA----QLRELERKIEELEAQIEKKRKR 918

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568962150  1236 LASLNRKYdQACEEKVSAKDEKELLHLSIEQE---IRDQKERCDKSLTTIMEL 1285
Cdd:TIGR02169  919 LSELKAKL-EALEEELSEIEDPKGEDEEIPEEelsLEDVQAELQRVEEEIRAL 970
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 720-1396 1.19e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 82.80  E-value: 1.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   720 QQVHSLTVEMKTRYVPL-RVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLlaeNDKLTKNVSRLEAvfvapekH 798
Cdd:TIGR02168  189 DRLEDILNELERQLKSLeRQAEKAERYKELKAELRELELALLVLRLEELREELEEL---QEELKEAEEELEE-------L 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   799 EKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLssqyvpaKTHEEVKASLNSTVEKTNRALLEAKKR 878
Cdd:TIGR02168  259 TAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQK-------QILRERLANLERQLEELEAQLEELESK 331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   879 FDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKA 958
Cdd:TIGR02168  332 LDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLER 411

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   959 QKKELDTIQECIK--LKYAPLARLEECERKFKATEKGLKEQLSEQthkcRQRDEEVKKGKQENERLRADLAALQKELQDR 1036
Cdd:TIGR02168  412 LEDRRERLQQEIEelLKKLEEAELKELQAELEELEEELEELQEEL----ERLEEALEELREELEEAEQALDAAERELAQL 487

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1037 NALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKL-VEEKAKQASEILAAQNLLQ----KQPVPLEQVEALKK 1111
Cdd:TIGR02168  488 QARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELIsVDEGYEAAIEAALGGRLQAvvveNLNAAKKAIAFLKQ 567

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1112 SLNG------------------TIEQLKEELRSKQRCLEREQQT----------------VSQLQQLLENQKNSS----- 1152
Cdd:TIGR02168  568 NELGrvtflpldsikgteiqgnDREILKNIEGFLGVAKDLVKFDpklrkalsyllggvlvVDDLDNALELAKKLRpgyri 647

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1153 VTLAEHL-----------------------KLKEaLEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLET 1209
Cdd:TIGR02168  648 VTLDGDLvrpggvitggsaktnssilerrrEIEE-LEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSR 726

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1210 REVVDMSKYKATKN----------DLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLhlsiEQEIRDQKERCDKSL 1279
Cdd:TIGR02168  727 QISALRKDLARLEAeveqleeriaQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEEL----EAQIEQLKEELKALR 802

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1280 TTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLtyssgspTKRQSQLVDTLQQRVRDLQQQLADADRQH 1359
Cdd:TIGR02168  803 EALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQ-------IEELSEDIESLAAEIEELEELIEELESEL 875

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|..
gi 568962150  1360 QEVIAIYRT-----HLLSAAQGHMDEDVQAALLQIIQMRQGL 1396
Cdd:TIGR02168  876 EALLNERASleealALLRSELEELSEELRELESKRSELRREL 917
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
749-1315 1.79e-15

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 82.03  E-value: 1.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  749 NVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQE 828
Cdd:PRK03918  180 RLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEE 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  829 KIRALMSENSSLKKTLssqyvpaKTHEEVKASLNStVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMK 908
Cdd:PRK03918  260 KIRELEERIEELKKEI-------EELEEKVKELKE-LKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIK 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  909 adyvSLEEHSRRMSTVSQSLKEAQEANAAIladhrqgqEEIVSLHAEIKAQKKELDTIQECIKLKyaplaRLEECERKFK 988
Cdd:PRK03918  332 ----ELEEKEERLEELKKKLKELEKRLEEL--------EERHELYEEAKAKKEELERLKKRLTGL-----TPEKLEKELE 394

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  989 ATEKGlKEQLSEQTHKCRQRDEEVkkgKQENERLRADLAALQKE-----LQDRNALAEEAREAERALSGKADELSKQLKD 1063
Cdd:PRK03918  395 ELEKA-KEEIEEEISKITARIGEL---KKEIKELKKAIEELKKAkgkcpVCGRELTEEHRKELLEEYTAELKRIEKELKE 470

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1064 LSQKYSDVKSEREKlVEEKAKQASEILAAQNLlqkqpvpLEQVEALKKSLNG-TIEQLK------EELRSKQRCLEREQQ 1136
Cdd:PRK03918  471 IEEKERKLRKELRE-LEKVLKKESELIKLKEL-------AEQLKELEEKLKKyNLEELEkkaeeyEKLKEKLIKLKGEIK 542

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1137 TVSQLQQLLENQKNSSVTLAEHLK-LKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREvvdm 1215
Cdd:PRK03918  543 SLKKELEKLEELKKKLAELEKKLDeLEEELAELLKELEELGFESVEELEERLKELEPFYNEYLELKDAEKELEREE---- 618

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1216 SKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDE----KELLHLSIEQEI---RDQKERCDKSLTTIMELQQR 1288
Cdd:PRK03918  619 KELKKLEEELDKAFEELAETEKRLEELRKELEELEKKYSEEeyeeLREEYLELSRELaglRAELEELEKRREEIKKTLEK 698

                         570       580       590
                  ....*....|....*....|....*....|
gi 568962150 1289 IQESAKQIEAKDNKITEL---LNDVERLKQ 1315
Cdd:PRK03918  699 LKEELEEREKAKKELEKLekaLERVEELRE 728
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 334-1239 8.59e-15

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 80.10  E-value: 8.59e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   334 ESEREKLKSLLAAKEKQHEESLRTIEALKNRfkyfesdhpgpgsypSNRKEDMLHKQGQMYTTEpqcaspgipphmHSRS 413
Cdd:TIGR02168  220 AELRELELALLVLRLEELREELEELQEELKE---------------AEEELEELTAELQELEEK------------LEEL 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   414 MLRPLELSlpsqtsyseneilkKELETLRTYYDSAKQDRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKD 493
Cdd:TIGR02168  273 RLEVSELE--------------EEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEE 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   494 VQkrmyESEGKVKQMQTHFLALKEHLTNEAAT--GSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKR 571
Cdd:TIGR02168  339 LA----ELEEKLEELKEELESLEAELEELEAEleELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLED 414

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   572 DEGRLVEENKRLQKEcgTCEVELERRGRRVVELEGQLKELGAKLalsvptEKFESMKSSLSNDINEKVKRLAEVGRDYES 651
Cdd:TIGR02168  415 RRERLQQEIEELLKK--LEEAELKELQAELEELEEELEELQEEL------ERLEEALEELREELEEAEQALDAAERELAQ 486

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   652 AQGEIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVS-----ELTLKNqTLQKDVEKLHADNK-LLNQQVHSL 725
Cdd:TIGR02168  487 LQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISvdegyEAAIEA-ALGGRLQAVVVENLnAAKKAIAFL 565

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   726 TVEMKTRYVPLRVSeemkkshDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVS-RLEAVFVAPEkhekelmg 804
Cdd:TIGR02168  566 KQNELGRVTFLPLD-------SIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSyLLGGVLVVDD-------- 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   805 LKSNIAELKKQLSELNKKCGEGQekiralmsensslkkTLSSQYVPAKTHEEVKASLNStvekTNRALLEAKKRFDDTSQ 884
Cdd:TIGR02168  631 LDNALELAKKLRPGYRIVTLDGD---------------LVRPGGVITGGSAKTNSSILE----RRREIEELEEKIEELEE 691

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   885 EVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELD 964
Cdd:TIGR02168  692 KIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLE 771

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   965 TIQEciklkyaplaRLEECERKfkatekglKEQLSEQThkcRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAR 1044
Cdd:TIGR02168  772 EAEE----------ELAEAEAE--------IEELEAQI---EQLKEELKALREALDELRAELTLLNEEAANLRERLESLE 830

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1045 EAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEEL 1124
Cdd:TIGR02168  831 RRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKR 910

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1125 RSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEkevgimkasLREKEEESQKKTKEVSKLQTEVQTTKQAL 1204
Cdd:TIGR02168  911 SELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLT---------LEEAEALENKIEDDEEEARRRLKRLENKI 981

                          890       900       910
                   ....*....|....*....|....*....|....*...
gi 568962150  1205 KNLETREVVDMSKYKATK---NDLETQISNLNDKLASL 1239
Cdd:TIGR02168  982 KELGPVNLAAIEEYEELKeryDFLTAQKEDLTEAKETL 1019
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 62-214 2.14e-14

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 78.37  E-value: 2.14e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   62 VASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLC 141
Cdd:PLN03192  532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568962150  142 dHGASVNAKDIDGRTpLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLT 214
Cdd:PLN03192  612 -HFASISDPHAAGDL-LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVD 682
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 33-181 3.21e-14

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 76.63  E-value: 3.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   33 DVEKVSSILAKKGVHPGKLDVEGRSAFHVVASK--GNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHA------LCL 104
Cdd:PHA03100   84 DVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIdlkilkLLI 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  105 QK------------LLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQL 172
Cdd:PHA03100  164 DKgvdinaknrvnyLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKL 243


                  ....*....
gi 568962150  173 LIDRGADVN 181
Cdd:PHA03100  244 LLNNGPSIK 252
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 683-1311 5.35e-14

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 76.98  E-value: 5.35e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   683 LEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKtryvplrvseEMKKSHDVNVEDLNKKLSEatq 762
Cdd:TIGR04523   80 LEQQIKDLNDKLKKNKDKINKLNSDLSKINSEIKNDKEQKNKLEVELN----------KLEKQKKENKKNIDKFLTE--- 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   763 rYTEKKQEAERLLAENDKLTKNVSRLEAVFvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIralmsensSLKK 842
Cdd:TIGR04523  147 -IKKKEKELEKLNNKYNDLKKQKEELENEL---NLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKKI--------QKNK 214

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   843 TLSSQYVPAKtheEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQmkadyvsLEEHSRRMS 922
Cdd:TIGR04523  215 SLESQISELK---KQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEKQKE-------LEQNNKKIK 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   923 TVSqslKEAQEANAAILADHRQGQEEIVS-LHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGL------- 994
Cdd:TIGR04523  285 ELE---KQLNQLKSEISDLNNQKEQDWNKeLKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSesensek 361

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   995 KEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSE 1074
Cdd:TIGR04523  362 QRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSE 441

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1075 REKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKqrclereqqtVSQLQQLLENQKNSSVT 1154
Cdd:TIGR04523  442 IKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSK----------EKELKKLNEEKKELEEK 511

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1155 LAEhlklkeaLEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVD-----MSKYKATKNDLEtqi 1229
Cdd:TIGR04523  512 VKD-------LTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKKENLEKEIDeknkeIEELKQTQKSLK--- 581

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1230 sNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTIMELQ---QRIQESAKQIEAKDNKITEL 1306
Cdd:TIGR04523  582 -KKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKskkNKLKQEVKQIKETIKEIRNK 660


                   ....*
gi 568962150  1307 LNDVE 1311
Cdd:TIGR04523  661 WPEII 665
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 474-1301 7.42e-14

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 77.08  E-value: 7.42e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   474 ERVKEDSDEQIKQLEDALKD-----------VQKRMYESEGKVKQMQTHFLALKEHLTNEAATGshriiEELREQLKDLK 542
Cdd:pfam15921   77 ERVLEEYSHQVKDLQRRLNEsnelhekqkfyLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQ-----EDLRNQLQNTV 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   543 GKYEGA-SAEVGKLRSQIKQSEMLVGEFKRDEGRLveenkrlqKECGTCEVELER-RGRRVVELEgqlkelgaklalSVP 620
Cdd:pfam15921  152 HELEAAkCLKEDMLEDSNTQIEQLRKMMLSHEGVL--------QEIRSILVDFEEaSGKKIYEHD------------SMS 211

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   621 TEKFESMKSSLSndinekvKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEH--EQLRSRLEQKSGELGKKVSELT 698
Cdd:pfam15921  212 TMHFRSLGSAIS-------KILRELDTEISYLKGRIFPVEDQLEALKSESQNKIELllQQHQDRIEQLISEHEVEITGLT 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   699 LKNQTLQKDVEKLHADNKLLNQQVHSLTV-------EMKTRYVPLRVS-EEMKKSHDVNVEDLNKKLSEATQRYTEKKQE 770
Cdd:pfam15921  285 EKASSARSQANSIQSQLEIIQEQARNQNSmymrqlsDLESTVSQLRSElREAKRMYEDKIEELEKQLVLANSELTEARTE 364

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   771 AERLLAENDKLTKNVSRLEAVFvapEKHEKELmglksniaELKKqlsELNKKCGEGQEKIRALMSEnssLKKTLSSQYVP 850
Cdd:pfam15921  365 RDQFSQESGNLDDQLQKLLADL---HKREKEL--------SLEK---EQNKRLWDRDTGNSITIDH---LRRELDDRNME 427

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   851 AKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKE 930
Cdd:pfam15921  428 VQRLEALLKAMKSECQGQMERQMAAIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQE 507

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   931 AQEANAAILAdhrqgqeEIVSLHAEIKAQKKELDTIQ-ECIKLKYAPlarlEECER-KFKATEKG-LKEQLSEQTHKCRQ 1007
Cdd:pfam15921  508 KERAIEATNA-------EITKLRSRVDLKLQELQHLKnEGDHLRNVQ----TECEAlKLQMAEKDkVIEILRQQIENMTQ 576

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1008 RdeeVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLS--------------QKYSDVKS 1073
Cdd:pfam15921  577 L---VGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSDLElekvklvnagserlRAVKDIKQ 653

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1074 EREKLVEEKAKQASEIlaaQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSV 1153
Cdd:pfam15921  654 ERDQLLNEVKTSRNEL---NSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAM 730

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1154 TLAEHLKLK----EALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTkqalknletreVVDMSKYKATKNDLETQI 1229
Cdd:pfam15921  731 GMQKQITAKrgqiDALQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTV-----------ATEKNKMAGELEVLRSQE 799

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568962150  1230 SNLNDKLASLNRKYDQACEEKVSAKD-----EKELLHLSIEQEIrDQKERCDKSLTTIMELQQRIQESAKQIEAKDN 1301
Cdd:pfam15921  800 RRLKEKVANMEVALDKASLQFAECQDiiqrqEQESVRLKLQHTL-DVKELQGPGYTSNSSMKPRLLQPASFTRTHSN 875
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
434-1024 1.27e-13

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 75.87  E-value: 1.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  434 LKKELETLRTYYDSAKQdRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQ---- 509
Cdd:PRK03918  212 ISSELPELREELEKLEK-EVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKelke 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  510 --THFLALKEhLTNEAATGSHRI----------IEELREQLKDLKGKyegaSAEVGKLRSQIKQSEMLVGEFKRDEgRLV 577
Cdd:PRK03918  291 kaEEYIKLSE-FYEEYLDELREIekrlsrleeeINGIEERIKELEEK----EERLEELKKKLKELEKRLEELEERH-ELY 364

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  578 EENKRLQKECGtcEVELERRGRRVVELEGQLKEL-GAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVgrdyESAQGEI 656
Cdd:PRK03918  365 EEAKAKKEELE--RLKKRLTGLTPEKLEKELEELeKAKEEIEEEISKITARIGELKKEIKELKKAIEEL----KKAKGKC 438

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  657 RQLKRDLESvraqhirpEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLhaDNKLLNQqvhSLTVEMKTRYVPL 736
Cdd:PRK03918  439 PVCGRELTE--------EHRKELLEEYTAELKRIEKELKEIEEKERKLRKELREL--EKVLKKE---SELIKLKELAEQL 505

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  737 RVSEEMKKSHDVnvedlnKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVfvapekhEKELMGLKSNIAELKKQL 816
Cdd:PRK03918  506 KELEEKLKKYNL------EELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEEL-------KKKLAELEKKLDELEEEL 572

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  817 SELNKKCGE-GQEKIRALMSENSSLKKtLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEV 895
Cdd:PRK03918  573 AELLKELEElGFESVEELEERLKELEP-FYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEE 651

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  896 LRRNLEnvqnqmKADYVSLEEHSRRMSTVSQSLKEAQEAnaaiLADHRqgqEEIVSLHAEIKAQKKELDTIQECIKLKYA 975
Cdd:PRK03918  652 LEKKYS------EEEYEELREEYLELSRELAGLRAELEE----LEKRR---EEIKKTLEKLKEELEEREKAKKELEKLEK 718

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|
gi 568962150  976 PLARLEECERKFKATEKGLKEQ-LSEQTHKCRQRDEEVKKGKQENERLRA 1024
Cdd:PRK03918  719 ALERVEELREKVKKYKALLKERaLSKVGEIASEIFEELTEGKYSGVRVKA 768
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 763-1361 1.86e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 75.48  E-value: 1.86e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   763 RYTEKKQEAERLLAENDKltkNVSRLEAVfvapekhekelmglksnIAELKKQLSELNKKcGEGQEKIRALMSENSSLKK 842
Cdd:TIGR02168  169 KYKERRKETERKLERTRE---NLDRLEDI-----------------LNELERQLKSLERQ-AEKAERYKELKAELRELEL 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   843 TLSS-QYVPAKTH----EEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEH 917
Cdd:TIGR02168  228 ALLVlRLEELREEleelQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQIL 307

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   918 SRRMSTVSQSLKEAQEanaaILADHRQGQEEivsLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQ 997
Cdd:TIGR02168  308 RERLANLERQLEELEA----QLEELESKLDE---LAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQ 380

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   998 LSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQdrNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREK 1077
Cdd:TIGR02168  381 LETLRSKVAQLELQIASLNNEIERLEARLERLEDRRE--RLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELER 458

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1078 LVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS-KQRCLEREQ--QTVSQLQQLLENQKN---- 1150
Cdd:TIGR02168  459 LEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGvKALLKNQSGlsGILGVLSELISVDEGyeaa 538

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1151 SSVTLAEHL-----KLKEALEKEVGIMKASLREKE---EESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATK 1222
Cdd:TIGR02168  539 IEAALGGRLqavvvENLNAAKKAIAFLKQNELGRVtflPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKAL 618

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1223 NDL------ETQISNLNDKLASLNRKY-------DQACEEKVSAK--DEKELLHLSIEQEIRDQKERCDkslttimELQQ 1287
Cdd:TIGR02168  619 SYLlggvlvVDDLDNALELAKKLRPGYrivtldgDLVRPGGVITGgsAKTNSSILERRREIEELEEKIE-------ELEE 691

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568962150  1288 RIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQE 1361
Cdd:TIGR02168  692 KIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEE 765
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 74-213 2.32e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 74.71  E-value: 2.32e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   74 ILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCP-SSIQLLCDHGASVNAKDI 152
Cdd:PHA02876  361 LLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPyMSVKTLIDRGANVNSKNK 440

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568962150  153 DGRTPLVLATQM-CRPTICQLLIDRGADVNSRDKQNRTALMLGCEYgcRDAVEVLVKNGADL 213
Cdd:PHA02876  441 DLSTPLHYACKKnCKLDVIEMLLDNGADVNAINIQNQYPLLIALEY--HGIVNILLHYGAEL 500
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 481-1284 3.32e-13

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 74.67  E-value: 3.32e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   481 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNeaatgSHRIIEELREQLKDLKGKyegasaevgklrsqIK 560
Cdd:TIGR04523   32 DTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINN-----SNNKIKILEQQIKDLNDK--------------LK 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   561 QSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERrgrrvveLEGQLKELGAKLAL-SVPTEKFESMKSSLSNDINEKV 639
Cdd:TIGR04523   93 KNKDKINKLNSDLSKINSEIKNDKEQKNKLEVELNK-------LEKQKKENKKNIDKfLTEIKKKEKELEKLNNKYNDLK 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   640 KRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLN 719
Cdd:TIGR04523  166 KQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKT 245

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   720 QQVHSLTVEMKTryvplrvseeMKKSHDVNVEDLNKKLSEATQryTEKKqeaerllaeNDKLTKNVSRLEAVFVA--PEK 797
Cdd:TIGR04523  246 TEISNTQTQLNQ----------LKDEQNKIKKQLSEKQKELEQ--NNKK---------IKELEKQLNQLKSEISDlnNQK 304

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   798 HEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSsqyvpaktheevkaSLNSTVEKTNRALLEAKk 877
Cdd:TIGR04523  305 EQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELT--------------NSESENSEKQRELEEKQ- 369

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   878 rfddtsQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEanaailaDHRQGQEEIVSLHAEIK 957
Cdd:TIGR04523  370 ------NEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQIKKLQQ-------EKELLEKEIERLKETII 436

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   958 AQKKELDTIQECIklkyaplARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQdrn 1037
Cdd:TIGR04523  437 KNNSEIKDLTNQD-------SVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELKSKEKELKKLNEEKK--- 506

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1038 alaeeareaeralsgkadELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPL--EQVEALKKSLNG 1115
Cdd:TIGR04523  507 ------------------ELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELkkENLEKEIDEKNK 568

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1116 TIEQLKEElrskQRCLEREQQTVSQL-QQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQ 1194
Cdd:TIGR04523  569 EIEELKQT----QKSLKKKQEEKQELiDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLK 644

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1195 TEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELL--HLSIEQEIRDQK 1272
Cdd:TIGR04523  645 QEVKQIKETIKEIRNKWPEIIKKIKESKTKIDDIIELMKDWLKELSLHYKKYITRMIRIKDLPKLEekYKEIEKELKKLD 724

                          810
                   ....*....|..
gi 568962150  1273 ErCDKSLTTIME 1284
Cdd:TIGR04523  725 E-FSKELENIIK 735
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 287-1033 4.05e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 74.71  E-value: 4.05e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   287 SFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLNEevmvaddLESEREKLKSLLAAKEKQHEESLRTIEALKNRFK 366
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEEELEELTAELQELEEKLEE-------LRLEVSELEEEIEELQKELYALANEISRLEQQKQ 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   367 YFesdhpgpgsypsNRKEDMLHKQGQMYTTEpqcaspgipphmhsrsmlrplelslpSQTSYSENEILKKELETLRTYYD 446
Cdd:TIGR02168  306 IL------------RERLANLERQLEELEAQ--------------------------LEELESKLDELAEELAELEEKLE 347

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   447 SAKQDRLKFQNELAHKVAECKALalecERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNEAATG 526
Cdd:TIGR02168  348 ELKEELESLEAELEELEAELEEL----ESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEI 423

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   527 S--------------HRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQkecgTCEV 592
Cdd:TIGR02168  424 EellkkleeaelkelQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLE----RLQE 499

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   593 ELERRGRRVVELEGQLKELGAKLA-----LSVPtEKFE-SMKSSLSNDINekvkrlAEVGRDYESAQGEIRQLKRD---- 662
Cdd:TIGR02168  500 NLEGFSEGVKALLKNQSGLSGILGvlselISVD-EGYEaAIEAALGGRLQ------AVVVENLNAAKKAIAFLKQNelgr 572

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   663 -----LESVRAQHIRPEEHEQLRS---------RLEQKSGELGKKVSELtLKNQTLQKDVEKLHADNKLLNQQVHSLTVE 728
Cdd:TIGR02168  573 vtflpLDSIKGTEIQGNDREILKNiegflgvakDLVKFDPKLRKALSYL-LGGVLVVDDLDNALELAKKLRPGYRIVTLD 651

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   729 ---MKTRYVPLRVSEEMKKS---HDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAvfvAPEKHEKEL 802
Cdd:TIGR02168  652 gdlVRPGGVITGGSAKTNSSileRRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRK---ELEELSRQI 728

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   803 MGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDT 882
Cdd:TIGR02168  729 SALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDEL 808

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   883 SQEVSKLRDENEVLRRNLENVQNQMkadyvslEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKE 962
Cdd:TIGR02168  809 RAELTLLNEEAANLRERLESLERRI-------AATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNE 881

                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568962150   963 LDTIQEciklkyaPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKEL 1033
Cdd:TIGR02168  882 RASLEE-------ALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERL 945
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 25-248 5.50e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 72.69  E-value: 5.50e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   25 LMKAAERGDVEKVSSILaKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCL 104
Cdd:PHA02874  128 LHYAIKKGDLESIKMLF-EYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACI 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  105 QKLLQYncpTEHVDLQ---GRTALHDAAMADcPSSIQLLCDHgASVNAKDIDGRTPLVLATQM-CRPTICQLLIDRGADV 180
Cdd:PHA02874  207 KLLIDH---GNHIMNKcknGFTPLHNAIIHN-RSAIELLINN-ASINDQDIDGSTPLHHAINPpCDIDIIDILLYHKADI 281

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568962150  181 NSRDKQNRTALMLGCEYGCRDAV-------EVLVKNGADLTLLDALGHDSsyyarIGDNLDILNLLKTASENTNK 248
Cdd:PHA02874  282 SIKDNKGENPIDTAFKYINKDPVikdiianAVLIKEADKLKDSDFLEHIE-----IKDNKEFSDFIKECNEEIED 351
PHA03095 PHA03095
ankyrin-like protein; Provisional
 29-239 5.80e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 73.14  E-value: 5.80e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   29 AERGDVEKVSSILAKKGvhpgklDVE-----GRSAFHVVASKGN---LECLNAILTHGIDVATRDSAGRNALHLAAKYGH 100
Cdd:PHA03095   22 ASNVTVEEVRRLLAAGA------DVNfrgeyGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNAT 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  101 ALCLQKLL-QYNCPTEHVDLQGRTALHDAAMADC--PSSIQLLCDHGASVNAKDIDGRTPL--VLATQMCRPTICQLLID 175
Cdd:PHA03095   96 TLDVIKLLiKAGADVNAKDKVGRTPLHVYLSGFNinPKVIRLLLRKGADVNALDLYGMTPLavLLKSRNANVELLRLLID 175

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  176 RGADVNSRDKQNRTALMLGCEYgCRD---AVEVLVKNGADLTLLDALGHDSSYYARIGD---NLDILNLL 239
Cdd:PHA03095  176 AGADVYAVDDRFRSLLHHHLQS-FKPrarIVRELIRAGCDPAATDMLGNTPLHSMATGSsckRSLVLPLL 244
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 425-1200 6.22e-13

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 74.00  E-value: 6.22e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   425 QTSYSENEILKKELETLRTYYDSAKQDrlkFQNELAHKVAECKALALECERVKEDSDEQIKQLedalkdvQKRMYESEGK 504
Cdd:pfam15921  116 QTKLQEMQMERDAMADIRRRESQSQED---LRNQLQNTVHELEAAKCLKEDMLEDSNTQIEQL-------RKMMLSHEGV 185

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   505 VKQMQTHFLALKE---------------HLTNeAATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQS-EMLVGE 568
Cdd:pfam15921  186 LQEIRSILVDFEEasgkkiyehdsmstmHFRS-LGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKiELLLQQ 264

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   569 FKRDEGRLVEENKrlqkecgtcevelerrgrrvVELEGQlkelgaklalsvpTEKFESMKSSlSNDINEKVKRLAEVGRD 648
Cdd:pfam15921  265 HQDRIEQLISEHE--------------------VEITGL-------------TEKASSARSQ-ANSIQSQLEIIQEQARN 310

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   649 YESAQgeIRQLKrDLESVRAQhIRPEEHEQLRSrLEQKSGELGKkvsELTLKNQTL---QKDVEKLHADNKLLNQQVHSL 725
Cdd:pfam15921  311 QNSMY--MRQLS-DLESTVSQ-LRSELREAKRM-YEDKIEELEK---QLVLANSELteaRTERDQFSQESGNLDDQLQKL 382

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   726 TVEMKTRYVPLRVSEEMkkshdvnvedlNKKLSEatqRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPE-----KHEK 800
Cdd:pfam15921  383 LADLHKREKELSLEKEQ-----------NKRLWD---RDTGNSITIDHLRRELDDRNMEVQRLEALLKAMKsecqgQMER 448

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   801 ELMGLKSNIAELKKqLSELNKKCGEGQEKIRALMSENSSLKKTLSSQyvpAKTHEEVKASLNS---TVEKTNRALLEAKK 877
Cdd:pfam15921  449 QMAAIQGKNESLEK-VSSLTAQLESTKEMLRKVVEELTAKKMTLESS---ERTVSDLTASLQEkerAIEATNAEITKLRS 524

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   878 RFDDTSQEVSKLRDENEVLRrnleNVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIK 957
Cdd:pfam15921  525 RVDLKLQELQHLKNEGDHLR----NVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEIN 600

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   958 AQKKELdtiQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQrdeeVKKGKQENERLRADLAALQKELQDRN 1037
Cdd:pfam15921  601 DRRLEL---QEFKILKDKKDAKIRELEARVSDLELEKVKLVNAGSERLRA----VKDIKQERDQLLNEVKTSRNELNSLS 673

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1038 ALAEEAREAERALSGKADELSKQLK-DLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNgT 1116
Cdd:pfam15921  674 EDYEVLKRNFRNKSEEMETTTNKLKmQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQ-F 752

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1117 IEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNS-----SVTLAEHLKLKEALEK-EVGIMKASLREKEEESQKKTKEV 1190
Cdd:pfam15921  753 LEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKmagelEVLRSQERRLKEKVANmEVALDKASLQFAECQDIIQRQEQ 832

                          810
                   ....*....|
gi 568962150  1191 SKLQTEVQTT 1200
Cdd:pfam15921  833 ESVRLKLQHT 842
Ank_2 pfam12796
Ankyrin repeats (3 copies);
25-112 1.32e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 64.75  E-value: 1.32e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150    25 LMKAAERGDVEKVSsILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIdvATRDSAGRNALHLAAKYGHALCL 104
Cdd:pfam12796    1 LHLAAKNGNLELVK-LLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIV 77


                   ....*...
gi 568962150   105 QKLLQYNC 112
Cdd:pfam12796   78 KLLLEKGA 85
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
483-1158 1.61e-12

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 72.40  E-value: 1.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  483 QIKQLEDALKDVQKRMYESEGKVKQMQThFLALKEHLTNEAATGSHRIIEELREqLKDLKGKYEGASAEVGKLRSQIKQS 562
Cdd:PRK03918  156 GLDDYENAYKNLGEVIKEIKRRIERLEK-FIKRTENIEELIKEKEKELEEVLRE-INEISSELPELREELEKLEKEVKEL 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  563 EMLVGEFKRdegrLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELgaklalsvpTEKFESMKSslsndINEKVKRL 642
Cdd:PRK03918  234 EELKEEIEE----LEKELESLEGSKRKLEEKIRELEERIEELKKEIEEL---------EEKVKELKE-----LKEKAEEY 295

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  643 AEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVSEltlknqtLQKDVEKLHADNKLLnQQV 722
Cdd:PRK03918  296 IKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKE-------LEKRLEELEERHELY-EEA 367

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  723 HSLTVEMKtryvplrvsEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAendkltknvsrleavfvapekhekEL 802
Cdd:PRK03918  368 KAKKEELE---------RLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITA------------------------RI 414

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  803 MGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENsslKKTLSSQYvpaktHEEVKaSLNSTVEKTNRALLEAKKRFddt 882
Cdd:PRK03918  415 GELKKEIKELKKAIEELKKAKGKCPVCGRELTEEH---RKELLEEY-----TAELK-RIEKELKEIEEKERKLRKEL--- 482

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  883 sQEVSKLRDENEVLRRNLEnVQNQMKADYVSLEEHsrrmstvsqSLKEAQEANaailADHRQGQEEIVSLHAEIKAQKKE 962
Cdd:PRK03918  483 -RELEKVLKKESELIKLKE-LAEQLKELEEKLKKY---------NLEELEKKA----EEYEKLKEKLIKLKGEIKSLKKE 547

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  963 LDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLR---ADLAALQKELQDRNAL 1039
Cdd:PRK03918  548 LEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEYLELKdaeKELEREEKELKKLEEE 627

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1040 AEEAREAERALSGKADELSKQLKDLSQKYSDvkSEREKLVEEKAKQASEILAAQNllqkqpvPLEQVEALKKSLNGTIEQ 1119
Cdd:PRK03918  628 LDKAFEELAETEKRLEELRKELEELEKKYSE--EEYEELREEYLELSRELAGLRA-------ELEELEKRREEIKKTLEK 698

                         650       660       670       680
                  ....*....|....*....|....*....|....*....|..
gi 568962150 1120 LKEEL---RSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEH 1158
Cdd:PRK03918  699 LKEELeerEKAKKELEKLEKALERVEELREKVKKYKALLKER 740
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1053-1396 1.99e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 72.28  E-value: 1.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1053 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQpvpLEQVEALKKSLNGTIEQLKEELRSKQRCLE 1132
Cdd:COG1196   233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEEL---ELELEEAQAEEYELLAELARLEQDIARLEE 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1133 REQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEE---ESQKKTKEVSKLQTEVQTTKQALKNLET 1209
Cdd:COG1196   310 RRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAelaEAEEALLEAEAELAEAEEELEELAEELL 389

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1210 REVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERcdksLTTIMELQQRI 1289
Cdd:COG1196   390 EALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL----EEEEEALLELL 465

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1290 QESAKQIEAKDNKITELLNDVERLKQALNGLSQLTyssgspTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYRTH 1369
Cdd:COG1196   466 AELLEEAALLEAALAELLEELAEAAARLLLLLEAE------ADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAA 539

                         330       340
                  ....*....|....*....|....*..
gi 568962150 1370 LLSAAQGHMDEDVQAALLQIIQMRQGL 1396
Cdd:COG1196   540 LEAALAAALQNIVVEDDEVAAAAIEYL 566
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 429-1277 4.54e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 71.25  E-value: 4.54e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   429 SENEILKKELETLRTYYDSAKQDRLKFQNELAHKVAECKALalecERVKEDSDEQIKQL-EDALKDVQKRMYESEGKVKQ 507
Cdd:TIGR02169  230 KEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEI----EQLLEELNKKIKDLgEEEQLRVKEKIGELEAEIAS 305

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   508 MQthflalkehltneaatgshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKEC 587
Cdd:TIGR02169  306 LE-------------------RSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEEL 366

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   588 GTCEVELERRGRRVVELEGQLKELGAKL---------------ALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESA 652
Cdd:TIGR02169  367 EDLRAELEEVDKEFAETRDELKDYREKLeklkreinelkreldRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDK 446

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   653 QGEIRQLKRDLESVRAQHIRPE-EHEQLRSRLEQKSGELGKKVSELtlknqtlqkdvEKLHADNKLLNQQVHSltvemkt 731
Cdd:TIGR02169  447 ALEIKKQEWKLEQLAADLSKYEqELYDLKEEYDRVEKELSKLQREL-----------AEAEAQARASEERVRG------- 508

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   732 ryvpLRVSEEMKKSHDVNVEDLNKKLSEATQRYtekkQEAERLLAENdkltknvsRLEAVFVAPEKHEKELmglksnIAE 811
Cdd:TIGR02169  509 ----GRAVEEVLKASIQGVHGTVAQLGSVGERY----ATAIEVAAGN--------RLNNVVVEDDAVAKEA------IEL 566

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   812 LKKqlselnKKCGEGQ----EKIRALMSENSSLKK-----------TLSSQYVPAktheeVKASLNSTVEKTNralLEAK 876
Cdd:TIGR02169  567 LKR------RKAGRATflplNKMRDERRDLSILSEdgvigfavdlvEFDPKYEPA-----FKYVFGDTLVVED---IEAA 632

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   877 KRFDDTSQEVSKlrdENEVLRRN-----LENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEanaAILADHRQGQEEIVS 951
Cdd:TIGR02169  633 RRLMGKYRMVTL---EGELFEKSgamtgGSRAPRGGILFSRSEPAELQRLRERLEGLKRELS---SLQSELRRIENRLDE 706

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   952 LHAEIKAQKKELDTIQeciklkyAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQK 1031
Cdd:TIGR02169  707 LSQELSDASRKIGEIE-------KEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEE 779

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1032 ELQDrnALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEIlaaQNLLQKQpvplEQVEALKK 1111
Cdd:TIGR02169  780 ALND--LEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEI---QELQEQR----IDLKEQIK 850

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1112 SLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKnssvtlaehlKLKEALEKEVGIMKASLREKEEESQKKTKEVS 1191
Cdd:TIGR02169  851 SIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLK----------KERDELEAQLRELERKIEELEAQIEKKRKRLS 920

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1192 KLQTEVQTTKQALKNLE---------TREVVDMSKYKATKNDLETQISnlndKLASLNRKYDQACEEKVSAKDEKELLHL 1262
Cdd:TIGR02169  921 ELKAKLEALEEELSEIEdpkgedeeiPEEELSLEDVQAELQRVEEEIR----ALEPVNMLAIQEYEEVLKRLDELKEKRA 996

                          890
                   ....*....|....*
gi 568962150  1263 SIEQEIRDQKERCDK 1277
Cdd:TIGR02169  997 KLEEERKAILERIEE 1011
PHA03095 PHA03095
ankyrin-like protein; Provisional
 32-232 5.76e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 69.67  E-value: 5.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   32 GDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGN-LECLNAILTHGIDVATRDSAGRNALH--LAAKYGHALCLQKLL 108
Cdd:PHA03095   60 EKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLL 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  109 QYNCPTEHVDLQGRTALH------DAamadCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRP--TICQLLIDRGADV 180
Cdd:PHA03095  140 RKGADVNALDLYGMTPLAvllksrNA----NVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKPraRIVRELIRAGCDP 215

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568962150  181 NSRDKQNRTALMLGCEYG-CRDA-VEVLVKNGADLTLLDALGHDSSYYARIGDN 232
Cdd:PHA03095  216 AATDMLGNTPLHSMATGSsCKRSlVLPLLIAGISINARNRYGQTPLHYAAVFNN 269
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 531-888 7.57e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 70.47  E-value: 7.57e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   531 IEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDE-------GRLVEENKRLQKECGTCEVELERRGRRVVE 603
Cdd:TIGR02168  679 IEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELeelsrqiSALRKDLARLEAEVEQLEERIAQLSKELTE 758

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   604 LEGQLKELGAKLALSVPTEK-FESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAqhiRPEEHEQLRSR 682
Cdd:TIGR02168  759 LEAEIEELEERLEEAEEELAeAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRE---RLESLERRIAA 835

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   683 LEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQ 762
Cdd:TIGR02168  836 TERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRR 915

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   763 RYTEKKQEAERLLAENDKLTKNVSRLEAVFvaPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRAL-------MS 835
Cdd:TIGR02168  916 ELEELREKLAQLELRLEGLEVRIDNLQERL--SEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKELgpvnlaaIE 993

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568962150   836 ENSSLKK---TLSSQYVPAkthEEVKASLNSTVEKTNRallEAKKRFDDTSQEVSK 888
Cdd:TIGR02168  994 EYEELKErydFLTAQKEDL---TEAKETLEEAIEEIDR---EARERFKDTFDQVNE 1043
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 59-239 8.96e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 68.92  E-value: 8.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   59 FHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQK-----LLQYNCPTEHVDLQGRTALHDAAMADC 133
Cdd:PHA03100   39 LYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLTDVKeivklLLEYGANVNAPDNNGITPLLYAISKKS 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  134 --PSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPT--ICQLLIDRGAD----------------VNSRDKQNRTALML 193
Cdd:PHA03100  119 nsYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDinaknrvnyllsygvpINIKDVYGFTPLHY 198

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 568962150  194 GCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLL 239
Cdd:PHA03100  199 AVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 35-222 1.01e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 68.84  E-value: 1.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   35 EKVSSILaKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPT 114
Cdd:PHA02874  105 DMIKTIL-DCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYA 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  115 EHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTIcQLLIDrGADVNSRDKQNRTALMLG 194
Cdd:PHA02874  184 NVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAI-ELLIN-NASINDQDIDGSTPLHHA 261

                         170       180
                  ....*....|....*....|....*....
gi 568962150  195 CEYGC-RDAVEVLVKNGADLTLLDALGHD 222
Cdd:PHA02874  262 INPPCdIDIIDILLYHKADISIKDNKGEN 290
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 763-1353 1.07e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 69.97  E-value: 1.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  763 RYTEKKQEAERLLAE--------NDK---LTKNVSRLE--------AVFVAPEKHEKELMGLKSNIAELKKQLSELNKKC 823
Cdd:COG1196   169 KYKERKEEAERKLEAteenlerlEDIlgeLERQLEPLErqaekaerYRELKEELKELEAELLLLKLRELEAELEELEAEL 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  824 GEGQEKIRALMSENSSLKKTLSSQyvpakthEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENV 903
Cdd:COG1196   249 EELEAELEELEAELAELEAELEEL-------RLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEEL 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  904 QNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQEciklkyaplARLEEc 983
Cdd:COG1196   322 EEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAE---------ELLEA- 391

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  984 erkfKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKD 1063
Cdd:COG1196   392 ----LRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAE 467

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1064 LSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQV-EALKKSLNGTIEQLKEELRSKQRCLE---------- 1132
Cdd:COG1196   468 LLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVkAALLLAGLRGLAGAVAVLIGVEAAYEaaleaalaaa 547

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1133 ------REQQTVSQLQQLLENQKNSSVTLAEHLKLK-----EALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTK 1201
Cdd:COG1196   548 lqnivvEDDEVAAAAIEYLKAAKAGRATFLPLDKIRaraalAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTL 627

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1202 QALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKydQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTT 1281
Cdd:COG1196   628 VAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRR--ELLAALLEAEAELEELAERLAEEELELEEALLAEEEE 705

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568962150 1282 IMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLA 1353
Cdd:COG1196   706 ERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIE 777
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 530-1126 3.95e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 68.04  E-value: 3.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  530 IIEELREQLKDLKG------KYEGASAEVGKLRSQ-----IKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRG 598
Cdd:COG1196   194 ILGELERQLEPLERqaekaeRYRELKEELKELEAEllllkLRELEAELEELEAELEELEAELEELEAELAELEAELEELR 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  599 RRVVELEGQLKELGAKLALSvptekfESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRaqhirpEEHEQ 678
Cdd:COG1196   274 LELEELELELEEAQAEEYEL------LAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELE------EELEE 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  679 LRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLS 758
Cdd:COG1196   342 LEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEE 421

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  759 EATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKcgEGQEKIRALMSENS 838
Cdd:COG1196   422 ELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEE--LAEAAARLLLLLEA 499

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  839 SLKKTLSSQYVPAKTHEEVKASLNSTVektnrALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQmkADYVSLEEHS 918
Cdd:COG1196   500 EADYEGFLEGVKAALLLAGLRGLAGAV-----AVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAA--IEYLKAAKAG 572

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  919 RRmsTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQL 998
Cdd:COG1196   573 RA--TFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVT 650

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  999 SEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKL 1078
Cdd:COG1196   651 LEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQL 730

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*...
gi 568962150 1079 VEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS 1126
Cdd:COG1196   731 EAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEA 778
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 33-212 5.97e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 66.17  E-value: 5.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   33 DVEKVSsILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGI---DVATRDsaGRNALHLAAKYGHALCLQKLLQ 109
Cdd:PHA02875   47 DSEAIK-LLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKfadDVFYKD--GMTPLHLATILKKLDIMKLLIA 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  110 YNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRT 189
Cdd:PHA02875  124 RGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCV 203

                         170       180
                  ....*....|....*....|....
gi 568962150  190 ALM-LGCEYGCRDAVEVLVKNGAD 212
Cdd:PHA02875  204 AALcYAIENNKIDIVRLFIKRGAD 227
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 24-259 9.05e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 66.63  E-value: 9.05e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   24 RLMKAAERGDVEKVSSILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALC 103
Cdd:PHA02876  147 KLIKERIQQDELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDT 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  104 LQKLLQYNCPTEHVDLQGRTALHDaamADCPSSIqLLCDHGASVNAKDIDGRTPLVLATQMcrPTICQL---LIDRGADV 180
Cdd:PHA02876  227 IKAIIDNRSNINKNDLSLLKAIRN---EDLETSL-LLYDAGFSVNSIDDCKNTPLHHASQA--PSLSRLvpkLLERGADV 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  181 NSRDKQNRTALMLGCEYGC-RDAVEVLVKNGADLTLLDALGHDSSYYARIGD-NLDILNLLKTASENTNkggGRELWRKG 258
Cdd:PHA02876  301 NAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVN---ARDYCDKT 377


                  .
gi 568962150  259 P 259
Cdd:PHA02876  378 P 378
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 67-227 2.48e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.60  E-value: 2.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   67 NLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGAS 146
Cdd:PHA02874  103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  147 VNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGcRDAVEVLVKNgADLTLLDALGHDSSYY 226
Cdd:PHA02874  183 ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN-RSAIELLINN-ASINDQDIDGSTPLHH 260


                  .
gi 568962150  227 A 227
Cdd:PHA02874  261 A 261
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
866-1362 4.00e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 64.68  E-value: 4.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  866 EKTNRALLEAKKRFDDTSQEVSKLRDE-NEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQ 944
Cdd:PRK02224  169 ERASDARLGVERVLSDQRGSLDQLKAQiEEKEEKDLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEE 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  945 GQEEIVSLHAEIKaqkKELDTIQECIKLKYAplarLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRA 1024
Cdd:PRK02224  249 RREELETLEAEIE---DLRETIAETEREREE----LAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELED 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1025 DLAALQKEL-------QDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQ 1097
Cdd:PRK02224  322 RDEELRDRLeecrvaaQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFG 401

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1098 KQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQK----NSSVTLAEHLKLKEALEKEVGIMK 1173
Cdd:PRK02224  402 DAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGKcpecGQPVEGSPHVETIEEDRERVEELE 481

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1174 ASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVD--MSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKV 1251
Cdd:PRK02224  482 AELEDLEEEVEEVEERLERAEDLVEAEDRIERLEERREDLEelIAERRETIEEKRERAEELRERAAELEAEAEEKREAAA 561

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1252 SAKDEKEllhlsieqEIRDQKERCDKSLTtimELQQRIqESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSS---- 1327
Cdd:PRK02224  562 EAEEEAE--------EAREEVAELNSKLA---ELKERI-ESLERIRTLLAAIADAEDEIERLREKREALAELNDERrerl 629

                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 568962150 1328 GSPTKRQSQLVDTLQQ-RVRDLQQQLADADRQHQEV 1362
Cdd:PRK02224  630 AEKRERKRELEAEFDEaRIEEAREDKERAEEYLEQV 665
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 428-1308 5.66e-10

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 64.22  E-value: 5.66e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   428 YSENEILKKELETLRTYYDSAKQ----DRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEG 503
Cdd:pfam02463  165 SRLKRKKKEALKKLIEETENLAEliidLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQE 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   504 KVKQMQTHFLALKEHLTNEAATgSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRL 583
Cdd:pfam02463  245 LLRDEQEEIESSKQEIEKEEEK-LAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEKEK 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   584 QKEcgtcEVELERRGRRVVELEGQLKELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDL 663
Cdd:pfam02463  324 KKA----EKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELEL 399

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   664 ESVRAQHIRPEEHeqlrsRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEmktryvplrvsEEMK 743
Cdd:pfam02463  400 KSEEEKEAQLLLE-----LARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELK-----------LLKD 463

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   744 KSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKC 823
Cdd:pfam02463  464 ELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKV 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   824 GEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENV 903
Cdd:pfam02463  544 AISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAK 623

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   904 QNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEeiVSLHAEIKAQKKELDTIQECIKLKYAPLARLEEC 983
Cdd:pfam02463  624 VVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKAS--LSELTKELLEIQELQEKAESELAKEEILRRQLEI 701

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   984 ERKFKATEKGLKEQLSEQTH-KCRQRDEEVKKGKQENERLRADLAALQKELQdrnalaeeaREAERALSGKADELSKQLK 1062
Cdd:pfam02463  702 KKKEQREKEELKKLKLEAEElLADRVQEAQDKINEELKLLKQKIDEEEEEEE---------KSRLKKEEKEEEKSELSLK 772

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1063 DLSQKYSDVKSEREKLVEEKAKQaseILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQ 1142
Cdd:pfam02463  773 EKELAEEREKTEKLKVEEEKEEK---LKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLE 849

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1143 QLLENQKNSSV-TLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKAT 1221
Cdd:pfam02463  850 KLAEEELERLEeEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEI 929

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1222 KNDLETQISNL----NDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTIMELQQRIQESAKQIE 1297
Cdd:pfam02463  930 LLKYEEEPEELlleeADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIR 1009

                          890
                   ....*....|.
gi 568962150  1298 AKDNKITELLN 1308
Cdd:pfam02463 1010 AIIEETCQRLK 1020
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 435-791 6.49e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 63.92  E-value: 6.49e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   435 KKELETLRTYYDSAKQDRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEgKVKQMQTHFLA 514
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVE-QLEERIAQLSK 754

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   515 LKEHLTNEAATGSHRIIE------ELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECG 588
Cdd:TIGR02168  755 ELTELEAEIEELEERLEEaeeelaEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIA 834

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   589 TCEVELERRGRRVVELEGQLKELGAKLAlsvptekfesmksSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRA 668
Cdd:TIGR02168  835 ATERRLEDLEEQIEELSEDIESLAAEIE-------------ELEELIEELESELEALLNERASLEEALALLRSELEELSE 901

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   669 QHirpEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHAdnKLLNQqvHSLTVEMKTRYVPLRVSEEMKKSHDv 748
Cdd:TIGR02168  902 EL---RELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQE--RLSEE--YSLTLEEAEALENKIEDDEEEARRR- 973

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 568962150   749 nVEDLNKKLSE-------ATQRYTEKKQEAERLLAENDKLTKNVSRLEAV 791
Cdd:TIGR02168  974 -LKRLENKIKElgpvnlaAIEEYEELKERYDFLTAQKEDLTEAKETLEEA 1022
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
752-1315 8.24e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 63.52  E-value: 8.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  752 DLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELkkqlselnkkcgegQEKIR 831
Cdd:PRK02224  203 DLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETLEAEIEDL--------------RETIA 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  832 ALMSENSSLKKTLSSQyvpAKTHEEVKASLNSTVEKTNRALLEAkkrfDDTSQEVSKLRDENEVLRRNLENVQNQMKADY 911
Cdd:PRK02224  269 ETEREREELAEEVRDL---RERLEELEEERDDLLAEAGLDDADA----EAVEARREELEDRDEELRDRLEECRVAAQAHN 341

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  912 VSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATE 991
Cdd:PRK02224  342 EEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREER 421

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  992 KGLKEQLSEQTHKCRQRDEEVkkgkQENERLRAdlaalqkelqdrnalaeeareaeralSGKADELSKQLKDlsqkysdv 1071
Cdd:PRK02224  422 DELREREAELEATLRTARERV----EEAEALLE--------------------------AGKCPECGQPVEG-------- 463

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1072 kSEREKLVEEKAKQASEILAAqnllqkqpvpLEQVEALKKSLNGTIEQLkEELRSKQRCLEREQQTVSQLQQLLENQKNS 1151
Cdd:PRK02224  464 -SPHVETIEEDRERVEELEAE----------LEDLEEEVEEVEERLERA-EDLVEAEDRIERLEERREDLEELIAERRET 531

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1152 ----SVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDmskykATKNDLET 1227
Cdd:PRK02224  532 ieekRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLERIRTLL-----AAIADAED 606

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1228 QISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIE----QEIRDQKERCDKSLTTIMELQQRIQES----AKQIEAK 1299
Cdd:PRK02224  607 EIERLREKREALAELNDERRERLAEKRERKRELEAEFDeariEEAREDKERAEEYLEQVEEKLDELREErddlQAEIGAV 686

                         570
                  ....*....|....*.
gi 568962150 1300 DNKITELLNDVERLKQ 1315
Cdd:PRK02224  687 ENELEELEELRERREA 702
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 768-1322 8.24e-10

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 63.60  E-value: 8.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   768 KQEAERLLAENDKLTKNVSRleAVFVAPEKHEKELMGLKSNIAELKKQLSELN----------KKCGEGQEKIRalmsen 837
Cdd:pfam15921   73 KEHIERVLEEYSHQVKDLQR--RLNESNELHEKQKFYLRQSVIDLQTKLQEMQmerdamadirRRESQSQEDLR------ 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   838 SSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLE-------------------AKKRFDDTSQEVSKLRDENEVLRR 898
Cdd:pfam15921  145 NQLQNTVHELEAAKCLKEDMLEDSNTQIEQLRKMMLShegvlqeirsilvdfeeasGKKIYEHDSMSTMHFRSLGSAISK 224

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   899 NLENVQNQ---MKADYVSLEEHSRRMSTVSQS-----LKEAQEANAAILADHrqgQEEIVSLHAEIKAQKKELDTIQeci 970
Cdd:pfam15921  225 ILRELDTEisyLKGRIFPVEDQLEALKSESQNkiellLQQHQDRIEQLISEH---EVEITGLTEKASSARSQANSIQ--- 298

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   971 klkyaplARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERlraDLAALQKELQDRNALAEEAREAERAL 1050
Cdd:pfam15921  299 -------SQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYED---KIEELEKQLVLANSELTEARTERDQF 368

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1051 SGKA----DELSKQLKDLSQKYSDVKSERE---KLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSL----NGTIEQ 1119
Cdd:pfam15921  369 SQESgnldDQLQKLLADLHKREKELSLEKEqnkRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLKAMksecQGQMER 448

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1120 LKEELRSKQRCLEReqqtVSQLQQLLENQKNSSVTLAEHLKLK----EALEKEVGIMKASLREKEEESQKKTKEVSKLQT 1195
Cdd:pfam15921  449 QMAAIQGKNESLEK----VSSLTAQLESTKEMLRKVVEELTAKkmtlESSERTVSDLTASLQEKERAIEATNAEITKLRS 524

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1196 EVQTTKQALKNLETRE--------VVDMSKYKATKND-----LETQISNLNDKLASLNRKYDQACEEKvsAKDEKELLHL 1262
Cdd:pfam15921  525 RVDLKLQELQHLKNEGdhlrnvqtECEALKLQMAEKDkvieiLRQQIENMTQLVGQHGRTAGAMQVEK--AQLEKEINDR 602

                          570       580       590       600       610       620       630
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568962150  1263 SIE-QEIRDQKercDKSLTTIMELQQRIQ----ESAKQIEAKDNKI----------TELLNDVERLKQALNGLSQ 1322
Cdd:pfam15921  603 RLElQEFKILK---DKKDAKIRELEARVSdlelEKVKLVNAGSERLravkdikqerDQLLNEVKTSRNELNSLSE 674
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 623-1365 2.79e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 62.01  E-value: 2.79e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   623 KFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHirpeehEQLRSRLEQKSGELGKKvseltLKNQ 702
Cdd:TIGR02169  146 DFISMSPVERRKIIDEIAGVAEFDRKKEKALEELEEVEENIERLDLII------DEKRQQLERLRREREKA-----ERYQ 214

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   703 TLQKDVEKLHADNKLLNQQVHsltvemktryvplrvsEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLT 782
Cdd:TIGR02169  215 ALLKEKREYEGYELLKEKEAL----------------ERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELN 278

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   783 KNVSRL---EAVFVAPEKHE--KELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEV 857
Cdd:TIGR02169  279 KKIKDLgeeEQLRVKEKIGEleAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEE 358

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   858 KASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLenvqNQMKADYVSLEEHSRRMstvSQSLKEAQEANAA 937
Cdd:TIGR02169  359 YAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREI----NELKRELDRLQEELQRL---SEELADLNAAIAG 431

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   938 ILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQ 1017
Cdd:TIGR02169  432 IEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRA 511

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1018 ENERLRADLAALQKELQDRNALAEEAREAERALSG---------------KADELSKQLK-------------------- 1062
Cdd:TIGR02169  512 VEEVLKASIQGVHGTVAQLGSVGERYATAIEVAAGnrlnnvvveddavakEAIELLKRRKagratflplnkmrderrdls 591

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1063 ---------------DLSQKY--------------SDVKSEREKLVE-----------EKA--------KQASEILAAQN 1094
Cdd:TIGR02169  592 ilsedgvigfavdlvEFDPKYepafkyvfgdtlvvEDIEAARRLMGKyrmvtlegelfEKSgamtggsrAPRGGILFSRS 671

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1095 LLQKQPVPLEQVEALKKSLNG------TIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLK-EALEK 1167
Cdd:TIGR02169  672 EPAELQRLRERLEGLKRELSSlqselrRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDlSSLEQ 751

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1168 EVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVD-MSKYKATKNDLETQISNLNDKLASLNRKYDQA 1246
Cdd:TIGR02169  752 EIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAeLSKLEEEVSRIEARLREIEQKLNRLTLEKEYL 831

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1247 CEEKVSAKDEKELLhlsiEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYS 1326
Cdd:TIGR02169  832 EKEIQELQEQRIDL----KEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEE 907

                          810       820       830
                   ....*....|....*....|....*....|....*....
gi 568962150  1327 SGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAI 1365
Cdd:TIGR02169  908 LEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEI 946
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 293-1152 3.02e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 62.01  E-value: 3.02e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   293 IENEDLREKLRKIqqEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIEALKNRFKyfesdh 372
Cdd:TIGR02169  211 ERYQALLKEKREY--EGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIK------ 282

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   373 pGPGSYPSNR-KEDMLHKQGQMYTTEPQCASpgipphmhsrSMLRPLELSLPSQTSYSENEILKKELETLRTYYDSAKQD 451
Cdd:TIGR02169  283 -DLGEEEQLRvKEKIGELEAEIASLERSIAE----------KERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKR 351

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   452 RLKFQNELAHKVAECKALALECERVKEDSDE---QIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNeaatgSH 528
Cdd:TIGR02169  352 RDKLTEEYAELKEELEDLRAELEEVDKEFAEtrdELKDYREKLEKLKREINELKRELDRLQEELQRLSEELAD-----LN 426

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   529 RIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERrgrrvveLEGQL 608
Cdd:TIGR02169  427 AAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAE-------AEAQA 499

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   609 KELGAKLALSVPTEKfesMKSSLSNDINEKVKRLAEVGRDY----ESAQG-EIRQLKRDLESVRAQHIrpeehEQLRSRl 683
Cdd:TIGR02169  500 RASEERVRGGRAVEE---VLKASIQGVHGTVAQLGSVGERYataiEVAAGnRLNNVVVEDDAVAKEAI-----ELLKRR- 570

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   684 eqksgelgkKVSELTL----KNQTLQKDVEKLHADNKL---LNqqvhslTVEMKTRYVP---------LRVS------EE 741
Cdd:TIGR02169  571 ---------KAGRATFlplnKMRDERRDLSILSEDGVIgfaVD------LVEFDPKYEPafkyvfgdtLVVEdieaarRL 635

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   742 MKKSHDVNVE-DLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVfvapekhEKELMGLKSNIAELKKQLSELN 820
Cdd:TIGR02169  636 MGKYRMVTLEgELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERLEGL-------KRELSSLQSELRRIENRLDELS 708

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   821 KKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDE-NEVLRRN 899
Cdd:TIGR02169  709 QELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEAlNDLEARL 788

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   900 LENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKlkyaplAR 979
Cdd:TIGR02169  789 SHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLN------GK 862

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   980 LEECERKFKATEKGLkeqlseqthkcRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSK 1059
Cdd:TIGR02169  863 KEELEEELEELEAAL-----------RDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEE 931

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1060 QLKDLsqkysdvkserEKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKE------ELRSKQRCLER 1133
Cdd:TIGR02169  932 ELSEI-----------EDPKGEDEEIPEEELSLEDVQAELQRVEEEIRALEPVNMLAIQEYEEvlkrldELKEKRAKLEE 1000

                          890
                   ....*....|....*....
gi 568962150  1134 EQQTVSQLQQLLENQKNSS 1152
Cdd:TIGR02169 1001 ERKAILERIEEYEKKKREV 1019
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 674-1351 3.22e-09

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 61.91  E-value: 3.22e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   674 EEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDveklhadnklLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDL 753
Cdd:TIGR00618  176 DQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLC----------TPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYL 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   754 NKKLSEATQRyTEKKQEAERLLAENDKLTKNVSRLEAvfvapEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRAL 833
Cdd:TIGR00618  246 TQKREAQEEQ-LKKQQLLKQLRARIEELRAQEAVLEE-----TQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSK 319

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   834 MSENSSLKKTLSSQYVPAKTHEEVKASLNStvektnraLLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQnQMKADYVS 913
Cdd:TIGR00618  320 MRSRAKLLMKRAAHVKQQSSIEEQRRLLQT--------LHSQEIHIRDAHEVATSIREISCQQHTLTQHIH-TLQQQKTT 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   914 LEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKY----APLARLEECERKFKA 989
Cdd:TIGR00618  391 LTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAqcekLEKIHLQESAQSLKE 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   990 TEKGL--KEQLSEQTHKCRQRDEEVKKGKQENER--------------LRADLAALQKELQDRNALAEEAREAERALSGK 1053
Cdd:TIGR00618  471 REQQLqtKEQIHLQETRKKAVVLARLLELQEEPCplcgscihpnparqDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQ 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1054 ADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSK------ 1127
Cdd:TIGR00618  551 LTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEqdlqdv 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1128 ----QRCLEREQQTVSQLQQLLENQKNSSVTlaEHLKLKEALEKEVGimkASLREKEEESQKKTKEVSKLQTEVQTTKQA 1203
Cdd:TIGR00618  631 rlhlQQCSQELALKLTALHALQLTLTQERVR--EHALSIRVLPKELL---ASRQLALQKMQSEKEQLTYWKEMLAQCQTL 705

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1204 LKNLET------REVVDMSKYKAT-KNDLETQISNLNDKLASLNRKYDQACEEKVSA---KDEKELLHLSIEQEIRDQKE 1273
Cdd:TIGR00618  706 LRELEThieeydREFNEIENASSSlGSDLAAREDALNQSLKELMHQARTVLKARTEAhfnNNEEVTAALQTGAELSHLAA 785

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1274 RCDKSLTTIMELQQRIQESAKQIEAK-----DNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDL 1348
Cdd:TIGR00618  786 EIQFFNRLREEDTHLLKTLEAEIGQEipsdeDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLT 865


                   ...
gi 568962150  1349 QQQ 1351
Cdd:TIGR00618  866 QEQ 868
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 55-209 3.83e-09

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 60.66  E-value: 3.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   55 GRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHdAAMADCP 134
Cdd:PHA02878  168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLH-ISVGYCK 246

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568962150  135 SS--IQLLCDHGASVNAKD-IDGRTPLVLATQmcRPTICQLLIDRGADVNSRDKQNRTAL-MLGCEYGCRDAVEVLVKN 209
Cdd:PHA02878  247 DYdiLKLLLEHGVDVNAKSyILGLTALHSSIK--SERKLKLLLEYGADINSLNSYKLTPLsSAVKQYLCINIGRILISN 323
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 638-1321 2.33e-08

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 59.08  E-value: 2.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   638 KVKRLAEVGRDYESAQGEIRQLKR-----DLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLH 712
Cdd:pfam12128  242 EFTKLQQEFNTLESAELRLSHLHFgyksdETLIASRQEERQETSAELNQLLRTLDDQWKEKRDELNGELSAADAAVAKDR 321

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   713 ADNKLLNQQvhsLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNK--KLSEATQRYTEKKQEAERLLAE---NDKLTKNVSR 787
Cdd:pfam12128  322 SELEALEDQ---HGAFLDADIETAAADQEQLPSWQSELENLEErlKALTGKHQDVTAKYNRRRSKIKeqnNRDIAGIKDK 398

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   788 LEAVFVAPEK-HEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSEnssLKKTLSSqyvpAKTHEEVKASLNSTVE 866
Cdd:pfam12128  399 LAKIREARDRqLAVAEDDLQALESELREQLEAGKLEFNEEEYRLKSRLGE---LKLRLNQ----ATATPELLLQLENFDE 471

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   867 KTNRALLEAKKRFddtsQEVSKLRDENEVLRRNLENVQnqmkadyVSLEEHSRRMSTVSQSLKEAQEanaailadhrQGQ 946
Cdd:pfam12128  472 RIERAREEQEAAN----AEVERLQSELRQARKRRDQAS-------EALRQASRRLEERQSALDELEL----------QLF 530

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   947 EEIVSLHAEIKaqkKELDTIQECIKlKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADL 1026
Cdd:pfam12128  531 PQAGTLLHFLR---KEAPDWEQSIG-KVISPELLHRTDLDPEVWDGSVGGELNLYGVKLDLKRIDVPEWAASEEELRERL 606

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1027 AALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVP-LEQ 1105
Cdd:pfam12128  607 DKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEKDKKNKALAERKDSANErLNS 686

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1106 VEALKKSLNGTIEQLKEELRSKQRCLEREQQtvsqlQQLLENQKNSSVTLAehlKLKEALEKEVGIMKASLREKEEESQK 1185
Cdd:pfam12128  687 LEAQLKQLDKKHQAWLEEQKEQKREARTEKQ-----AYWQVVEGALDAQLA---LLKAAIAARRSGAKAELKALETWYKR 758

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1186 KTKE-------VSKLQTEVQTTKQALKNLETRE--------------VVDMSKYKATKNDLETQISNLNDKLASLnrkyd 1244
Cdd:pfam12128  759 DLASlgvdpdvIAKLKREIRTLERKIERIAVRRqevlryfdwyqetwLQRRPRLATQLSNIERAISELQQQLARL----- 833

                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568962150  1245 QACEEKVSAKDEKELlhlsieQEIRDQKERCDKSLTTIMELQQRIQE--SAKQIEAKDNKITELLNDVERLKQALNGLS 1321
Cdd:pfam12128  834 IADTKLRRAKLEMER------KASEKQQVRLSENLRGLRCEMSKLATlkEDANSEQAQGSIGERLAQLEDLKLKRDYLS 906
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 431-1281 2.61e-08

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 58.91  E-value: 2.61e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   431 NEILKKELETLRTYYDSAKQDRLKFQNELAHKVAEckalalecervkedsdeqikqLEDALKDVQKRMYESegKVKQMQT 510
Cdd:TIGR01612  944 KEILNKNIDTIKESNLIEKSYKDKFDNTLIDKINE---------------------LDKAFKDASLNDYEA--KNNELIK 1000

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   511 HFLALKEHLTNEAATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQS-EMLVGEFKRDEGRLVEE-NKRLQKECG 588
Cdd:TIGR01612 1001 YFNDLKANLGKNKENMLYHQFDEKEKATNDIEQKIEDANKNIPNIEIAIHTSiYNIIDEIEKEIGKNIELlNKEILEEAE 1080

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   589 TCEVELE--RRGRRVVELEGQLKELGAKLALSVptEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESV 666
Cdd:TIGR01612 1081 INITNFNeiKEKLKHYNFDDFGKEENIKYADEI--NKIKDDIKNLDQKIDHHIKALEEIKKKSENYIDEIKAQINDLEDV 1158

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   667 RAQHIRPEEHEQLRSRLEQKSGELGKK------VSELTLKNQTLQKD---VEKLHADNKLLNQQVHSLTVEMKTRyvPLR 737
Cdd:TIGR01612 1159 ADKAISNDDPEEIEKKIENIVTKIDKKkniydeIKKLLNEIAEIEKDktsLEEVKGINLSYGKNLGKLFLEKIDE--EKK 1236

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   738 VSEEMKKSHDVNVEDLNkKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELmglkSNIAELKKQLS 817
Cdd:TIGR01612 1237 KSEHMIKAMEAYIEDLD-EIKEKSPEIENEMGIEMDIKAEMETFNISHDDDKDHHIISKKHDENI----SDIREKSLKII 1311

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   818 ELNKKcgegqekiralMSENSSLKKTLSSQYVPAKTH-EEVKASLNSTVEKTN-RALLEAKKRFDDTSQEVSKLRDENEV 895
Cdd:TIGR01612 1312 EDFSE-----------ESDINDIKKELQKNLLDAQKHnSDINLYLNEIANIYNiLKLNKIKKIIDEVKEYTKEIEENNKN 1380

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   896 LRRNLENVQNQMKA--DYVSLEE-HSRRMSTVSQSLKEAQEANAAILADHrqgqeeIVSLHAEIKAQKKELDTIQECIKL 972
Cdd:TIGR01612 1381 IKDELDKSEKLIKKikDDINLEEcKSKIESTLDDKDIDECIKKIKELKNH------ILSEESNIDTYFKNADENNENVLL 1454

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   973 KYaplarlEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLradlaalqKELQDRNALAEEareaeralsg 1052
Cdd:TIGR01612 1455 LF------KNIEMADNKSQHILKIKKDNATNDHDFNINELKEHIDKSKGC--------KDEADKNAKAIE---------- 1510

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1053 KADELSKQLK----DLSQKYSDVKSEREKlveEKAKQASEILAAQNLLQKQPVPLEQvealkkslnGTIEQLKEELRSKQ 1128
Cdd:TIGR01612 1511 KNKELFEQYKkdvtELLNKYSALAIKNKF---AKTKKDSEIIIKEIKDAHKKFILEA---------EKSEQKIKEIKKEK 1578

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1129 RCLERE-------QQTVSQLQQLLENQKNSSVTLA-------EHLKLKEALEKEVGIMkaSLREKEEESQKKTKEVSKLQ 1194
Cdd:TIGR01612 1579 FRIEDDaakndksNKAAIDIQLSLENFENKFLKISdikkkinDCLKETESIEKKISSF--SIDSQDTELKENGDNLNSLQ 1656

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1195 TEVQTTKQALKNLETRevvdmskyKATKNDLETQISNLNDKLASLNRKYDQACEEKVS--AKDEKELLHlSIEQEIRDQK 1272
Cdd:TIGR01612 1657 EFLESLKDQKKNIEDK--------KKELDELDSEIEKIEIDVDQHKKNYEIGIIEKIKeiAIANKEEIE-SIKELIEPTI 1727


                   ....*....
gi 568962150  1273 ERCDKSLTT 1281
Cdd:TIGR01612 1728 ENLISSFNT 1736
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 483-1080 3.06e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 58.41  E-value: 3.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  483 QIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNEAATgshriIEELREQLKDLKGKYEGASAEVGKLRSQIKQS 562
Cdd:COG1196   233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE-----LEELELELEEAQAEEYELLAELARLEQDIARL 307

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  563 EMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptEKFESMKSSLSNDINEKVKRL 642
Cdd:COG1196   308 EERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAEL------AEAEEALLEAEAELAEAEEEL 381

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  643 AEVGRDYESAQGEIRQLKRDLESVRAQHirpEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQV 722
Cdd:COG1196   382 EELAEELLEALRAAAELAAQLEELEEAE---EALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEE 458

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  723 HSLTVEMKTRYVPLRVSEEmkkshdvNVEDLNKKLSEATQRYTEKKQEAE------------RLLAENDKLTKNVSRLEA 790
Cdd:COG1196   459 EALLELLAELLEEAALLEA-------ALAELLEELAEAAARLLLLLEAEAdyegflegvkaaLLLAGLRGLAGAVAVLIG 531

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  791 VFVAPEKHEKELMGlkSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNR 870
Cdd:COG1196   532 VEAAYEAALEAALA--AALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLR 609

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  871 ALLEAKKRFDDTSQevsklrdENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIV 950
Cdd:COG1196   610 EADARYYVLGDTLL-------GRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELE 682

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  951 SLHAEIKAQKKELDTIQEciklkyaplaRLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQ 1030
Cdd:COG1196   683 ELAERLAEEELELEEALL----------AEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEA 752

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568962150 1031 KELQDRNALAEEAREAERALSGK--------------ADELSKQLKDLSQKYSDVKSEREKLVE 1080
Cdd:COG1196   753 LEELPEPPDLEELERELERLEREiealgpvnllaieeYEELEERYDFLSEQREDLEEARETLEE 816
Ank_4 pfam13637
Ankyrin repeats (many copies);
55-108 3.63e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.12  E-value: 3.63e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568962150    55 GRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLL 108
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 68-252 3.74e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.31  E-value: 3.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   68 LECLNAILTHGIDVATR--DSA---------GRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSS 136
Cdd:PHA02875    4 VALCDAILFGELDIARRllDIGinpnfeiydGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  137 IQLLCDHGASVNakDI---DGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADL 213
Cdd:PHA02875   84 VEELLDLGKFAD--DVfykDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACL 161

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 568962150  214 TLLDALGHDSSYYARIGDNLDILNLLKTASENTNKGGGR 252
Cdd:PHA02875  162 DIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKN 200
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 137-234 3.89e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.99  E-value: 3.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  137 IQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLL 216
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177

                          90
                  ....*....|....*...
gi 568962150  217 DALGHDSSYYARIGDNLD 234
Cdd:PTZ00322  178 GANAKPDSFTGKPPSLED 195
Ank_4 pfam13637
Ankyrin repeats (many copies);
121-174 3.96e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 50.74  E-value: 3.96e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568962150   121 GRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLI 174
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 432-711 4.85e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 57.76  E-value: 4.85e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   432 EILKKELETLRTYYDSAKQDRLKFQNE---LAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQM 508
Cdd:TIGR02168  736 ARLEAEVEQLEERIAQLSKELTELEAEieeLEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLL 815

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   509 QTHFLALKEHLTNEAATGS--HRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKE 586
Cdd:TIGR02168  816 NEEAANLRERLESLERRIAatERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSE 895

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   587 CGTCEVELERRGRRVVELEGQLKELGAKLAlsvpteKFESMKSSLSNDINEKVKRLAEVGRD--------YESAQGEIRQ 658
Cdd:TIGR02168  896 LEELSEELRELESKRSELRRELEELREKLA------QLELRLEGLEVRIDNLQERLSEEYSLtleeaealENKIEDDEEE 969

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568962150   659 LKRDLESVRAQHIR--------PEEHEQLRSRLEqksgELGKKVSELTLKNQTLQKDVEKL 711
Cdd:TIGR02168  970 ARRRLKRLENKIKElgpvnlaaIEEYEELKERYD----FLTAQKEDLTEAKETLEEAIEEI 1026
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 949-1361 1.40e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 56.18  E-value: 1.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   949 IVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAA 1028
Cdd:TIGR04523   28 ANKQDTEEKQLEKKLKTIKNELKNKEKELKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSK 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1029 LQKELQDRNalaeeareaeralsgkadelsKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEA 1108
Cdd:TIGR04523  108 INSEIKNDK---------------------EQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKK 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1109 LKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTK 1188
Cdd:TIGR04523  167 QKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSNLKKKIQKNKSLESQISELKKQNNQLKDNIEKKQQEINEKTT 246

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1189 EVSKLQTEVQTTKQALKNLETR---EVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKV-----SAKDEKELL 1260
Cdd:TIGR04523  247 EISNTQTQLNQLKDEQNKIKKQlseKQKELEQNNKKIKELEKQLNQLKSEISDLNNQKEQDWNKELkselkNQEKKLEEI 326

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1261 HLSI---EQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQL 1337
Cdd:TIGR04523  327 QNQIsqnNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLESKIQNQEKL 406

                          410       420
                   ....*....|....*....|....
gi 568962150  1338 VDTLQQRVRDLQQQLADADRQHQE 1361
Cdd:TIGR04523  407 NQQKDEQIKKLQQEKELLEKEIER 430
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
482-697 1.41e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 56.46  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  482 EQIKQLEDALKDVQK--RMYESEGKVKQMQTHFLALKEHLTNEAATgshRIIEELREQLKDLKGKYEGASAEVGKLRSQI 559
Cdd:COG4913   249 EQIELLEPIRELAERyaAARERLAELEYLRAALRLWFAQRRLELLE---AELEELRAELARLEAELERLEARLDALREEL 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  560 kqsEMLVGEFKRDEGRLVEenkRLQKECGTCEVELERRGRRVVELEGQLKELGAKLALSVPT-----EKFESMKSSLSND 634
Cdd:COG4913   326 ---DELEAQIRGNGGDRLE---QLEREIERLERELEERERRRARLEALLAALGLPLPASAEEfaalrAEAAALLEALEEE 399

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568962150  635 INEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIR-PEEHEQLRSRLEQksgELGKKVSEL 697
Cdd:COG4913   400 LEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNiPARLLALRDALAE---ALGLDEAEL 460
PRK01156 PRK01156
chromosome segregation protein; Provisional
 627-1216 3.25e-07

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 54.91  E-value: 3.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  627 MKSSLSNDINEKVKRLAEVgRDYESAQGEIRQLKRDLESVRAQhirPEEHEQLRSRLEQKSGEL---GKKVSELTLKNQT 703
Cdd:PRK01156  140 MDSLISGDPAQRKKILDEI-LEINSLERNYDKLKDVIDMLRAE---ISNIDYLEEKLKSSNLELeniKKQIADDEKSHSI 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  704 LQKDVEKLHADNKLLNQQVHSLTVEMKTryvpLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLA-ENDKLT 782
Cdd:PRK01156  216 TLKEIERLSIEYNNAMDDYNNLKSALNE----LSSLEDMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKiINDPVY 291

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  783 KNVSRLEAVFvapeKHEKELMGLKSNIAELKKQLS--ELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKAS 860
Cdd:PRK01156  292 KNRNYINDYF----KYKNDIENKKQILSNIDAEINkyHAIIKKLSVLQKDYNDYIKKKSRYDDLNNQILELEGYEMDYNS 367

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  861 LNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKadyVSLEEHSRRMSTVSQSL------KEAQEA 934
Cdd:PRK01156  368 YLKSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKELNEIN---VKLQDISSKVSSLNQRIralrenLDELSR 444

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  935 NAAILADH-----------RQGQEEIVS--------LHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLK 995
Cdd:PRK01156  445 NMEMLNGQsvcpvcgttlgEEKSNHIINhynekksrLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKI 524

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  996 EQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDR------NALAEEAREAERALSGKADELSKQLKDLSQKYS 1069
Cdd:PRK01156  525 ESARADLEDIKIKINELKDKHDKYEEIKNRYKSLKLEDLDSkrtswlNALAVISLIDIETNRSRSNEIKKQLNDLESRLQ 604

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1070 DVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQK 1149
Cdd:PRK01156  605 EIEIGFPDDKSYIDKSIREIENEANNLNNKYNEIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLK 684

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568962150 1150 NSSVTLAEHLKLKEALEKEVGImkasLREKEEESQKKTKEVSKLQTEVQTTKQALKNL-ETREVVDMS 1216
Cdd:PRK01156  685 KSRKALDDAKANRARLESTIEI----LRTRINELSDRINDINETLESMKKIKKAIGDLkRLREAFDKS 748
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 15-221 3.94e-07

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 54.70  E-value: 3.94e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150    15 SAEWNKYDDRLMKAAERGDVEKVSsilaKKGVHPGKLDVE-----GRSAFHVVASKGNLECLNAIL-THGIDVATrdsaG 88
Cdd:TIGR00870   11 ESPLSDEEKAFLPAAERGDLASVY----RDLEEPKKLNINcpdrlGRSALFVAAIENENLELTELLlNLSCRGAV----G 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150    89 RNALHLAAKYGHA---LCLQKLLQ---YNCPTEHVDLQ-------GRTALHDAAMADCPSSIQLLCDHGASVNAK----- 150
Cdd:TIGR00870   83 DTLLHAISLEYVDaveAILLHLLAafrKSGPLELANDQytseftpGITALHLAAHRQNYEIVKLLLERGASVPARacgdf 162

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   151 -----DID----GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALML-------GCEY----------------G 198
Cdd:TIGR00870  163 fvksqGVDsfyhGESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLlvmenefKAEYeelscqmynfalslldK 242

                          250       260
                   ....*....|....*....|....
gi 568962150   199 CRDAVEV-LVKNGADLTLLDALGH 221
Cdd:TIGR00870  243 LRDSKELeVILNHQGLTPLKLAAK 266
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 63-191 4.76e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.25  E-value: 4.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   63 ASKGNLECLNAILT-HGIDVATRDSAGRNALHLAAKYGHALCLQKLLqyNCPTEHVDL-------QGRTALHDAAMADCP 134
Cdd:cd22192    25 AKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLM--EAAPELVNEpmtsdlyQGETALHIAVVNQNL 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568962150  135 SSIQLLCDHGASVNA---------KDID-----GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTAL 191
Cdd:cd22192   103 NLVRELIARGADVVSpratgtffrPGPKnliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
PRK01156 PRK01156
chromosome segregation protein; Provisional
 865-1356 1.10e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 53.37  E-value: 1.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  865 VEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKadyvSLEEHSRRMSTVSQSLKEAQEANAAILADHRQ 944
Cdd:PRK01156  161 INSLERNYDKLKDVIDMLRAEISNIDYLEEKLKSSNLELENIKK----QIADDEKSHSITLKEIERLSIEYNNAMDDYNN 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  945 GQEEIvslhAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRA 1024
Cdd:PRK01156  237 LKSAL----NELSSLEDMKNRYESEIKTAESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQ 312

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1025 DLAALQKELQDRNALAEEAREAERALS------GKADELSKQLKDLSQKYSD-------VKSEREKLVEEKAKQASEILA 1091
Cdd:PRK01156  313 ILSNIDAEINKYHAIIKKLSVLQKDYNdyikkkSRYDDLNNQILELEGYEMDynsylksIESLKKKIEEYSKNIERMSAF 392

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1092 AQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRS---KQRCLEREQQTVSQLQQLLENQKNSSVTlAEHLKlKEALEKE 1168
Cdd:PRK01156  393 ISEILKIQEIDPDAIKKELNEINVKLQDISSKVSSlnqRIRALRENLDELSRNMEMLNGQSVCPVC-GTTLG-EEKSNHI 470

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1169 VGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACE 1248
Cdd:PRK01156  471 INHYNEKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEE 550

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1249 ekvsAKDEKELLHLSIEQEIRDQ--KERCDKSLTTIMELQQRIQESAKQI---EAKDNKITELLNDVERLKQALNGLSQL 1323
Cdd:PRK01156  551 ----IKNRYKSLKLEDLDSKRTSwlNALAVISLIDIETNRSRSNEIKKQLndlESRLQEIEIGFPDDKSYIDKSIREIEN 626

                         490       500       510
                  ....*....|....*....|....*....|....*..
gi 568962150 1324 TYSSGSPTKRQSQ----LVDTLQQRVRDLQQQLADAD 1356
Cdd:PRK01156  627 EANNLNNKYNEIQenkiLIEKLRGKIDNYKKQIAEID 663
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 871-1092 1.16e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 52.46  E-value: 1.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  871 ALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIV 950
Cdd:COG4942    14 AAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  951 SLHAEIKAQKKEL-DTIQECIKLKYAPLARL----EECERKFKATE--KGLKEQLSEQTHKCRQRDEEVKKGKQENERLR 1023
Cdd:COG4942    94 ELRAELEAQKEELaELLRALYRLGRQPPLALllspEDFLDAVRRLQylKYLAPARREQAEELRADLAELAALRAELEAER 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568962150 1024 ADLAALQKELQDR----NALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAA 1092
Cdd:COG4942   174 AELEALLAELEEEraalEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAA 246
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
926-1388 1.21e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 53.23  E-value: 1.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  926 QSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLkYAPLARLEECERKFKATEKGLkEQLSEQTHKC 1005
Cdd:COG4717    81 KEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQL-LPLYQELEALEAELAELPERL-EELEERLEEL 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1006 RQRDEEVKKGKQENERLRADLAALQKELQDRNALA-EEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAK 1084
Cdd:COG4717   159 RELEEELEELEAELAELQEELEELLEQLSLATEEElQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEA 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1085 Q---------------ASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQK 1149
Cdd:COG4717   239 AaleerlkearlllliAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEELEE 318

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1150 NSSVTLAEHLKLKEALEKEvgiMKASLREKEEESQKKTKEVSKLQTEVQttkqaLKNLETREVVDMSKYKAtkndletqi 1229
Cdd:COG4717   319 EELEELLAALGLPPDLSPE---ELLELLDRIEELQELLREAEELEEELQ-----LEELEQEIAALLAEAGV--------- 381

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1230 snlnDKLASLNRKYDQAcEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTimELQQRIQESAKQIEAKDNKITELLND 1309
Cdd:COG4717   382 ----EDEEELRAALEQA-EEYQELKEELEELEEQLEELLGELEELLEALDEE--ELEEELEELEEELEELEEELEELREE 454

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568962150 1310 VERLKQALNGLsqltyssgsptkRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYrtHLLSAAQGHMDEDVQAALLQ 1388
Cdd:COG4717   455 LAELEAELEQL------------EEDGELAELLQELEELKAELRELAEEWAALKLAL--ELLEEAREEYREERLPPVLE 519
46 PHA02562
endonuclease subunit; Provisional
 481-712 1.37e-06

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 52.71  E-value: 1.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  481 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLTNEAATgSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIK 560
Cdd:PHA02562  187 DMKIDHIQQQIKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKT-IKAEIEELTDELLNLVMDIEDPSAALNKLNTAAA 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  561 QSEMLVGEFKRDEgRLVEENkrlqKECGTCEVELERRGRRVVELEGQLKELGAKLALSvpTEKFESMKsSLSNDINEKVK 640
Cdd:PHA02562  266 KIKSKIEQFQKVI-KMYEKG----GVCPTCTQQISEGPDRITKIKDKLKELQHSLEKL--DTAIDELE-EIMDEFNEQSK 337

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568962150  641 RLAEVgrdyesaQGEIRQLKRDLESVRAQHIRPE-EHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLH 712
Cdd:PHA02562  338 KLLEL-------KNKISTNKQSLITLVDKAKKVKaAIEELQAEFVDNAEELAKLQDELDKIVKTKSELVKEKY 403
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 631-1258 1.49e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 52.80  E-value: 1.49e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   631 LSNDINEKVKRLAEVGRDYESAQGEIR-QLKRDLESVraQHIRPEEHEQLRSRLEQ------KSGELGKKVSELTLKNQT 703
Cdd:pfam05483  188 LNNNIEKMILAFEELRVQAENARLEMHfKLKEDHEKI--QHLEEEYKKEINDKEKQvsllliQITEKENKMKDLTFLLEE 265

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   704 LQKDVEKLHADNKL-------LNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQrytEKKQEAERLLA 776
Cdd:pfam05483  266 SRDKANQLEEKTKLqdenlkeLIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTE---EKEAQMEELNK 342

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   777 ENDKLTKNVSRLEAVFVAPEKHEK-ELMGLKSNIAELKKQLSELNKKCGEGQEKIRAlmsensslkktlssqyvpaKTHE 855
Cdd:pfam05483  343 AKAAHSFVVTEFEATTCSLEELLRtEQQRLEKNEDQLKIITMELQKKSSELEEMTKF-------------------KNNK 403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   856 EVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVL----RRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEA 931
Cdd:pfam05483  404 EVELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQELIFLlqarEKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKE 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   932 QEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEE 1011
Cdd:pfam05483  484 KLKNIELTAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDE 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1012 VK--KGKQENERLRADLAALQKELQDRnalaeeareaerALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEI 1089
Cdd:pfam05483  564 VKckLDKSEENARSIEYEVLKKEKQMK------------ILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQL 631

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1090 LAAQNllqkqpvpleQVEALKKSLNGTIEQLKEELRSKQRclEREQQTVSQlQQLLENQKNSSVTLAEHLKLKEALEKEV 1169
Cdd:pfam05483  632 NAYEI----------KVNKLELELASAKQKFEEIIDNYQK--EIEDKKISE-EKLLEEVEKAKAIADEAVKLQKEIDKRC 698

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1170 gimKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREvvdmskyKATKNDLETQISNLNDKLASLNRKYDQACEE 1249
Cdd:pfam05483  699 ---QHKIAEMVALMEKHKHQYDKIIEERDSELGLYKNKEQEQ-------SSAKAALEIELSNIKAELLSLKKQLEIEKEE 768


                   ....*....
gi 568962150  1250 KVSAKDEKE 1258
Cdd:pfam05483  769 KEKLKMEAK 777
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 767-1362 1.53e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 52.92  E-value: 1.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   767 KKQEAERLLAEND------KLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRA-LMSENSS 839
Cdd:pfam12128  219 NRQQVEHWIRDIQaiagimKIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQETSAELNQlLRTLDDQ 298

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   840 LKKTLSSQYVPAKTHEEVKASLNSTVEktnrALLEAKKRFDDTSQEVSKLRDENEVLRRN-LENVQNQMKAdyvsLEEHS 918
Cdd:pfam12128  299 WKEKRDELNGELSAADAAVAKDRSELE----ALEDQHGAFLDADIETAAADQEQLPSWQSeLENLEERLKA----LTGKH 370

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   919 RRMSTVSQSLKEA-QEANAAILADHRQGQ----EEIVSLHAEIKAQKKELDtiQECIKLKYAPLARLEECERKFKATEKG 993
Cdd:pfam12128  371 QDVTAKYNRRRSKiKEQNNRDIAGIKDKLakirEARDRQLAVAEDDLQALE--SELREQLEAGKLEFNEEEYRLKSRLGE 448

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   994 LKEQL------SEQTHKCRQRDEEVKKGKQENERLRADLAALQKELqdrnalaeeareaeRALSGKADELSKQLKDLSQK 1067
Cdd:pfam12128  449 LKLRLnqatatPELLLQLENFDERIERAREEQEAANAEVERLQSEL--------------RQARKRRDQASEALRQASRR 514

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1068 YSDVKSEREKLVEEKAKQASEILAaqnLLQKQPVPLEQVEA--LKKSLNGTIEqLKEELRSKQRCLEREQQTVS-QLQQL 1144
Cdd:pfam12128  515 LEERQSALDELELQLFPQAGTLLH---FLRKEAPDWEQSIGkvISPELLHRTD-LDPEVWDGSVGGELNLYGVKlDLKRI 590

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1145 lenQKNSSVTLAEHLKLK-EALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVvdmskykatkn 1223
Cdd:pfam12128  591 ---DVPEWAASEEELRERlDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLR----------- 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1224 DLETQISNLNDKLA-SLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKErcdKSLTTIMELQQRIQESakqIEAKDNK 1302
Cdd:pfam12128  657 RLFDEKQSEKDKKNkALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKE---QKREARTEKQAYWQVV---EGALDAQ 730

                          570       580       590       600       610       620
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568962150  1303 I----TELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEV 1362
Cdd:pfam12128  731 LallkAAIAARRSGAKAELKALETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVRRQEV 794
PHA02798 PHA02798
ankyrin-like protein; Provisional
 137-240 1.62e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 52.53  E-value: 1.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  137 IQLLCDHGASVNAKDIDGRTPL--VLATQMCRPT---ICQLLIDRGADVNSRDKQNRTAL--MLGCEY-GCRDAVEVLVK 208
Cdd:PHA02798   54 VKLFINLGANVNGLDNEYSTPLctILSNIKDYKHmldIVKILIENGADINKKNSDGETPLycLLSNGYiNNLEILLFMIE 133

                          90       100       110
                  ....*....|....*....|....*....|...
gi 568962150  209 NGADLTLLDALGHDS-SYYARIGDNLDIlNLLK 240
Cdd:PHA02798  134 NGADTTLLDKDGFTMlQVYLQSNHHIDI-EIIK 165
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
481-672 1.72e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 52.61  E-value: 1.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  481 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLA---LKEHLTNEAATGS-HRIIEELREQLKDLK---GKYEGASAEVG 553
Cdd:COG4913   616 EAELAELEEELAEAEERLEALEAELDALQERREAlqrLAEYSWDEIDVASaEREIAELEAELERLDassDDLAALEEQLE 695

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  554 KLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVVelEGQLKELGAKLALSVPTEKFESMKSSLSN 633
Cdd:COG4913   696 ELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLAR--LELRALLEERFAAALGDAVERELRENLEE 773

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 568962150  634 DInekvkrlaevgrdyESAQGEIRQLKRDLESVRAQHIR 672
Cdd:COG4913   774 RI--------------DALRARLNRAEEELERAMRAFNR 798
PRK01156 PRK01156
chromosome segregation protein; Provisional
 779-1357 1.88e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 52.60  E-value: 1.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  779 DKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSqyvpAKTHEEVK 858
Cdd:PRK01156  176 DMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNE----LSSLEDMK 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  859 ASLNSTVEKTNRAL---LEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEAN 935
Cdd:PRK01156  252 NRYESEIKTAESDLsmeLEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKYHAIIKKL 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  936 AAILADHRQgQEEIVSLHAEIKAQKKELDTIQEciklKYAPLArleeceRKFKATEKGLKEQLSEQTHKCRQRDEEVKKG 1015
Cdd:PRK01156  332 SVLQKDYND-YIKKKSRYDDLNNQILELEGYEM----DYNSYL------KSIESLKKKIEEYSKNIERMSAFISEILKIQ 400

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1016 KQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQK---------YSDVKSER--EKLVEEKAK 1084
Cdd:PRK01156  401 EIDPDAIKKELNEINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLNGQsvcpvcgttLGEEKSNHiiNHYNEKKSR 480

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1085 QASEILAAQNLLQKQPVPLEQVEALKKSLNGtieqlkeelrSKQRCLEREQQTVSQLQQLLENQKNSSVTLAE-HLKLKE 1163
Cdd:PRK01156  481 LEEKIREIEIEVKDIDEKIVDLKKRKEYLES----------EEINKSINEYNKIESARADLEDIKIKINELKDkHDKYEE 550

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1164 ALEKEVGIMKASLREKEEE-----SQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLAS 1238
Cdd:PRK01156  551 IKNRYKSLKLEDLDSKRTSwlnalAVISLIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANN 630

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1239 LNRKYDQAcEEKVSAKDEkellhlsIEQEIRDQKERCDKslttimelQQRIQESAKQIEAKDNKITELLNDVERLKQALN 1318
Cdd:PRK01156  631 LNNKYNEI-QENKILIEK-------LRGKIDNYKKQIAE--------IDSIIPDLKEITSRINDIEDNLKKSRKALDDAK 694

                         570       580       590
                  ....*....|....*....|....*....|....*....
gi 568962150 1319 glsqltyssgSPTKRQSQLVDTLQQRVRDLQQQLADADR 1357
Cdd:PRK01156  695 ----------ANRARLESTIEILRTRINELSDRINDINE 723
Ank_2 pfam12796
Ankyrin repeats (3 copies);
158-239 2.21e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.03  E-value: 2.21e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   158 LVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGAdltlLDALGHDSS--YYARIGDNLDI 235
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD----VNLKDNGRTalHYAARSGHLEI 76


                   ....
gi 568962150   236 LNLL 239
Cdd:pfam12796   77 VKLL 80
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 655-1315 2.31e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 52.28  E-value: 2.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   655 EIRQLKRDLESVRAQHIRPEEHEQLRSRLEQKSGELGKKVSELTLKNQtLQKDVEKLHADNKLLNQQVHSLtveMKTRYV 734
Cdd:pfam02463  184 NLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDY-LKLNEERIDLLQELLRDEQEEI---ESSKQE 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   735 PLRVSEEMKKSHDVNVEDLN-KKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFV--APEKHEKELMGLKSNIAE 811
Cdd:pfam02463  260 IEKEEEKLAQVLKENKEEEKeKKLQEEELKLLAKEEEELKSELLKLERRKVDDEEKLKESekEKKKAEKELKKEKEEIEE 339

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   812 LKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRD 891
Cdd:pfam02463  340 LEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLED 419

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   892 ENEVLRRNLENVQNqmkadyvsleehsrrmstVSQSLKEAQEANAAILADHRQGQEEI-VSLHAEIKAQKKELDTIQECI 970
Cdd:pfam02463  420 LLKEEKKEELEILE------------------EEEESIELKQGKLTEEKEELEKQELKlLKDELELKKSEDLLKETQLVK 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   971 KLKYapLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERAL 1050
Cdd:pfam02463  482 LQEQ--LELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADE 559

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1051 SGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQA-----SEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELR 1125
Cdd:pfam02463  560 VEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAvleidPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKE 639

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1126 SKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQT--TKQA 1203
Cdd:pfam02463  640 SAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKklKLEA 719

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1204 LKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTIM 1283
Cdd:pfam02463  720 EELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQ 799

                          650       660       670
                   ....*....|....*....|....*....|..
gi 568962150  1284 ELQQRIQESAKQIEAKDNKITELLNDVERLKQ 1315
Cdd:pfam02463  800 EEELRALEEELKEEAELLEEEQLLIEQEEKIK 831
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1010-1211 2.40e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 51.69  E-value: 2.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1010 EEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEI 1089
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAEL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1090 LAAQNLLQKQPV---PLEQVEALKKSLNGT-----------IEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNS-SVT 1154
Cdd:COG4942   100 EAQKEELAELLRalyRLGRQPPLALLLSPEdfldavrrlqyLKYLAPARREQAEELRADLAELAALRAELEAERAElEAL 179

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568962150 1155 LAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETRE 1211
Cdd:COG4942   180 LAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEA 236
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 436-1323 2.68e-06

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 52.36  E-value: 2.68e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   436 KELETLRTYYDSAKQDRLKFQNELAHKVAEckalaLECERvkedsdEQIKQLEDALKDVQKRMYESEgkvkQMQTHFLAL 515
Cdd:TIGR00606  203 QEHQMELKYLKQYKEKACEIRDQITSKEAQ-----LESSR------EIVKSYENELDPLKNRLKEIE----HNLSKIMKL 267

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   516 KEHLTNEAATGSHRiiEELREQLKDLKGK-YEGASAEVGKLRsqikqsemlvgEFKRDEGRLVEEnkrlqkECGTCEVEL 594
Cdd:TIGR00606  268 DNEIKALKSRKKQM--EKDNSELELKMEKvFQGTDEQLNDLY-----------HNHQRTVREKER------ELVDCQREL 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   595 ERRGRRVVELEGQLKELgaklalsvpteKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHirpE 674
Cdd:TIGR00606  329 EKLNKERRLLNQEKTEL-----------LVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERGPFSERQIK---N 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   675 EHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRvseemkkshdvNVEDLN 754
Cdd:TIGR00606  395 FHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELK-----------FVIKEL 463

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   755 KKLSEATQRYTEKKQEAERLLAENDKLTKNVSrleavfvaPEKHEKELMGLKSNIAELKKQLSELNKKCGE-GQEKIRAL 833
Cdd:TIGR00606  464 QQLEGSSDRILELDQELRKAERELSKAEKNSL--------TETLKKEVKSLQNEKADLDRKLRKLDQEMEQlNHHTTTRT 535

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   834 MSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEakKRFDDTSQEVSKLRDENEVLRRNL---ENVQNQMKAD 910
Cdd:TIGR00606  536 QMEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFPNKKQLE--DWLHSKSKEINQTRDRLAKLNKELaslEQNKNHINNE 613

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   911 YVSLEEhsrRMSTVSQSLKEAQEANAAiladhrqgQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEE-------- 982
Cdd:TIGR00606  614 LESKEE---QLSSYEDKLFDVCGSQDE--------ESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQLTDenqsccpv 682

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   983 CERKFKaTEKGLKEQLSEQTHKCR-------QRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKAD 1055
Cdd:TIGR00606  683 CQRVFQ-TEAELQEFISDLQSKLRlapdklkSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQ 761

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1056 ELSKQLKDLSQKYSDVKSErEKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNG--TIEQLKEELRSKQRCLER 1133
Cdd:TIGR00606  762 RLKNDIEEQETLLGTIMPE-EESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQGSDLdrTVQQVNQEKQEKQHELDT 840

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1134 EQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTK-------QALKN 1206
Cdd:TIGR00606  841 VVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKeqdspleTFLEK 920

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1207 LETREVVDMSKYKATK-------NDLETQISNLNDKLASLNRKYDQACEEKVSAKdEKELLHLSIE-QEIRDQKERCDKS 1278
Cdd:TIGR00606  921 DQQEKEELISSKETSNkkaqdkvNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQK-ETELNTVNAQlEECEKHQEKINED 999

                          890       900       910       920
                   ....*....|....*....|....*....|....*....|....*...
gi 568962150  1279 LTTIMEL--QQRIQESAKQIEAKDNKITELLNDVER-LKQALNGLSQL 1323
Cdd:TIGR00606 1000 MRLMRQDidTQKIQERWLQDNLTLRKRENELKEVEEeLKQHLKEMGQM 1047
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 796-1370 3.16e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 51.65  E-value: 3.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   796 EKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSS-------LKKTLSSQYVPAKTHE-------EVKASL 861
Cdd:pfam05483  109 QENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNAtrhlcnlLKETCARSAEKTKKYEyereetrQVYMDL 188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   862 NSTVEKTNRALLEAKKRFDDTSQEVS-KLRDENEVL-------RRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQE 933
Cdd:pfam05483  189 NNNIEKMILAFEELRVQAENARLEMHfKLKEDHEKIqhleeeyKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRD 268

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   934 ANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKlkyaplarleecerKFKATEKGLKEQLSEQTHKCRQRDEEVK 1013
Cdd:pfam05483  269 KANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQ--------------RSMSTQKALEEDLQIATKTICQLTEEKE 334

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1014 KGKQENERLRADLAALQKELQdrnalaeeareaerALSGKADELskqlkdlsqkysdVKSEREKLveEKAKQASEILAAQ 1093
Cdd:pfam05483  335 AQMEELNKAKAAHSFVVTEFE--------------ATTCSLEEL-------------LRTEQQRL--EKNEDQLKIITME 385

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1094 nlLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKnssvtlaEHLKLKEALEKEVGIMK 1173
Cdd:pfam05483  386 --LQKKSSELEEMTKFKNNKEVELEELKKILAEDEKLLDEKKQFEKIAEELKGKEQ-------ELIFLLQAREKEIHDLE 456

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1174 ASLREKEEESQKKTKEVSKLQTEVQttKQALKNLETREVVDMSKYKATKNDLETQ------------ISNLNDKLASLNR 1241
Cdd:pfam05483  457 IQLTAIKTSEEHYLKEVEDLKTELE--KEKLKNIELTAHCDKLLLENKELTQEASdmtlelkkhqedIINCKKQEERMLK 534

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1242 KYDQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLS 1321
Cdd:pfam05483  535 QIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELH 614

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*....
gi 568962150  1322 QLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYRTHL 1370
Cdd:pfam05483  615 QENKALKKKGSAENKQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEI 663
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 479-921 3.93e-06

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 51.71  E-value: 3.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   479 DSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHltNEAATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSq 558
Cdd:pfam01576  107 DLEEQLDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQ--NSKLSKERKLLEERISEFTSNLAEEEEKAKSLSKLKN- 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   559 ikQSEMLVGEFkrdEGRLVEENK---RLQKECGTCEVELERRGRRVVELEGQLKELGAKLAlsvpteKFESMKSSLSNDI 635
Cdd:pfam01576  184 --KHEAMISDL---EERLKKEEKgrqELEKAKRKLEGESTDLQEQIAELQAQIAELRAQLA------KKEEELQAALARL 252

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   636 NEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEEH-------------------------EQLRSRLEQKSGEL 690
Cdd:pfam01576  253 EEETAQKNNALKKIRELEAQISELQEDLESERAARNKAEKQrrdlgeelealkteledtldttaaqQELRSKREQEVTEL 332

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   691 GKKVSELTLKNQTLQKDVEKLHAD----------------------NKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDV 748
Cdd:pfam01576  333 KKALEEETRSHEAQLQEMRQKHTQaleelteqleqakrnkanlekaKQALESENAELQAELRTLQQAKQDSEHKRKKLEG 412

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   749 NVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVapeKHEKELMGLKSNIAELKKQLSELNKKCGEGQE 828
Cdd:pfam01576  413 QLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNI---KLSKDVSSLESQLQDTQELLQEETRQKLNLST 489

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   829 KIRALMSENSSLKKTLSSQyvpakthEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMK 908
Cdd:pfam01576  490 RLRQLEDERNSLQEQLEEE-------EEAKRNVERQLSTLQAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLE 562

                          490
                   ....*....|....*.
gi 568962150   909 ---ADYVSLEEHSRRM 921
Cdd:pfam01576  563 ekaAAYDKLEKTKNRL 578
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
458-944 4.09e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 51.58  E-value: 4.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  458 ELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRmyesegkvkqmqthflalKEHLTNEAATGSHRiIEELREQ 537
Cdd:PRK02224  255 TLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEE------------------RDDLLAEAGLDDAD-AEAVEAR 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  538 LKDLKGKYEGASAEVGKLRSQI----KQSEMLVGEFKRDEGR---LVEENKRLQKECGTCEVELERRGRRVVELEGQLKE 610
Cdd:PRK02224  316 REELEDRDEELRDRLEECRVAAqahnEEAESLREDADDLEERaeeLREEAAELESELEEAREAVEDRREEIEELEEEIEE 395

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  611 LGAKLA-LSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVR----AQHIRPEEHEQLRSRLEQ 685
Cdd:PRK02224  396 LRERFGdAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVEEAEALLEAGKcpecGQPVEGSPHVETIEEDRE 475

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  686 KSGELGKKVSELTLKNQTLQKDVEKLHADNKL------LNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSE 759
Cdd:PRK02224  476 RVEELEAELEDLEEEVEEVEERLERAEDLVEAedrierLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEE 555

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  760 ATQRYTEKKQEAERLLAE----NDKLTKNVSRLEAVfvapekheKELMGLKSNIAELKKQLSELNKK---CGEGQEKIRA 832
Cdd:PRK02224  556 KREAAAEAEEEAEEAREEvaelNSKLAELKERIESL--------ERIRTLLAAIADAEDEIERLREKreaLAELNDERRE 627

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  833 LMSENSSLKKTLSSQYVPAKTHE--EVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEvlrrNLENVQNQMKAd 910
Cdd:PRK02224  628 RLAEKRERKRELEAEFDEARIEEarEDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELE----ELEELRERREA- 702

                         490       500       510
                  ....*....|....*....|....*....|....
gi 568962150  911 yvsLEEHSRRMSTVSQSLKEAQEANAAILADHRQ 944
Cdd:PRK02224  703 ---LENRVEALEALYDEAEELESMYGDLRAELRQ 733
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 137-239 4.29e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 51.03  E-value: 4.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  137 IQLLCDHGASVNAKDID-GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTL 215
Cdd:PHA02878  150 TKLLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA 229

                          90       100
                  ....*....|....*....|....*...
gi 568962150  216 LDALG----HDSSYYARigdNLDILNLL 239
Cdd:PHA02878  230 RDKCGntplHISVGYCK---DYDILKLL 254
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 412-908 4.80e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 51.17  E-value: 4.80e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   412 RSMLRPLELSLPSQTSYSE-NEILKKELETLRTYYDSAKQDRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDA 490
Cdd:TIGR04523  193 KNKLLKLELLLSNLKKKIQkNKSLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSEK 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   491 LKDVQKrmyeSEGKVKQMQTHFLALKEHLTNEAATGSHRIIEELREQLKDLKGKYEgasaevgKLRSQIKQSEMLVGEFK 570
Cdd:TIGR04523  273 QKELEQ----NNKKIKELEKQLNQLKSEISDLNNQKEQDWNKELKSELKNQEKKLE-------EIQNQISQNNKIISQLN 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   571 RDEGRLVEENKRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptEKFESMKSSLSNDINEKVKRLAEVGRDYE 650
Cdd:TIGR04523  342 EQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEI------KNLESQINDLESKIQNQEKLNQQKDEQIK 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   651 SAQGEIRQLKRDLESVRAQHIrpeEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMK 730
Cdd:TIGR04523  416 KLQQEKELLEKEIERLKETII---KNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKELK 492

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   731 TRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRY----TEKKQEAERLLAENDKLTKNVSRLEAvfvapEKHEKELMGLK 806
Cdd:TIGR04523  493 SKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIekleSEKKEKESKISDLEDELNKDDFELKK-----ENLEKEIDEKN 567

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   807 SNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLssqyvpaktheevkASLNSTVEKTNRALLEAKKRFDDTSQEV 886
Cdd:TIGR04523  568 KEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEI--------------EEKEKKISSLEKELEKAKKENEKLSSII 633

                          490       500
                   ....*....|....*....|..
gi 568962150   887 SKLRDENEVLRRNLENVQNQMK 908
Cdd:TIGR04523  634 KNIKSKKNKLKQEVKQIKETIK 655
PRK01156 PRK01156
chromosome segregation protein; Provisional
 287-883 5.38e-06

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 51.06  E-value: 5.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  287 SFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLNEEVMVADD---LESEREKLKSLLAAKEKQHEEslrtIEALKN 363
Cdd:PRK01156  205 QIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMknrYESEIKTAESDLSMELEKNNY----YKELEE 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  364 RFKYFESDhpgPGSYPSNRKEDMLHKQGQMYTTEPQCASPGIPPHMHSRSMLRPLELslpsQTSYSENEILKKELETLRT 443
Cdd:PRK01156  281 RHMKIIND---PVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKYHAIIKKLSVL----QKDYNDYIKKKSRYDDLNN 353

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  444 YYDSAKQDRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDA----------LKDVQKRMYESEGKVKQMQTHFL 513
Cdd:PRK01156  354 QILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISEILKIQeidpdaikkeLNEINVKLQDISSKVSSLNQRIR 433

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  514 ALKEHLtneaatgshriiEELREQLKDLKGKyegASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVE 593
Cdd:PRK01156  434 ALRENL------------DELSRNMEMLNGQ---SVCPVCGTTLGEEKSNHIINHYNEKKSRLEEKIREIEIEVKDIDEK 498

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  594 LERRGRRVVELEGQLKElgaklALSVPTEKFESMKSSLSnDINEKVKRLAEVGRDYESAQGEIRQLK-RDLESVRAQH-- 670
Cdd:PRK01156  499 IVDLKKRKEYLESEEIN-----KSINEYNKIESARADLE-DIKIKINELKDKHDKYEEIKNRYKSLKlEDLDSKRTSWln 572

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  671 ----IRPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSh 746
Cdd:PRK01156  573 alavISLIDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSYIDKSIREIENEANNLNNKYNEIQENKILIEKLRGK- 651

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  747 dvnVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCgEG 826
Cdd:PRK01156  652 ---IDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRTRINELSDRINDINETL-ES 727

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568962150  827 QEKIRALMSENSSLKKTLSSQYVPAKTHEEVKASLNStveKTNRALLEAKKRFDDTS 883
Cdd:PRK01156  728 MKKIKKAIGDLKRLREAFDKSGVPAMIRKSASQAMTS---LTRKYLFEFNLDFDDID 781
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 827-1353 7.07e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 50.74  E-value: 7.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   827 QEKIRALMSENSSLKKTLSSQYVPAKTHE----EVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLEN 902
Cdd:TIGR00618  151 QGEFAQFLKAKSKEKKELLMNLFPLDQYTqlalMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKH 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   903 VQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAiladhRQGQEEIVSLHAEIKAQKKELDtiQECIKLKYAP-LARLE 981
Cdd:TIGR00618  231 LREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQL-----RARIEELRAQEAVLEETQERIN--RARKAAPLAAhIKAVT 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   982 ECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADE----- 1056
Cdd:TIGR00618  304 QIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTqhiht 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1057 LSKQLKDLSQKYSDVKSEREKLVEEKAKQASEiLAAQNLLQKQPVPLEQVEALkkslngtieqlkeelrskqrclerEQQ 1136
Cdd:TIGR00618  384 LQQQKTTLTQKLQSLCKELDILQREQATIDTR-TSAFRDLQGQLAHAKKQQEL------------------------QQR 438

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1137 TVSQLQQLLENQknssvtlAEHLKLKEALEKEvgiMKASLREKEEESQKK---TKEVSKLQTEVQTTKQALKNLETREVV 1213
Cdd:TIGR00618  439 YAELCAAAITCT-------AQCEKLEKIHLQE---SAQSLKEREQQLQTKeqiHLQETRKKAVVLARLLELQEEPCPLCG 508

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1214 DMSKYKATKNDLETQISNLNDKLASLNR-KYDQACEEKVSAKDEKELLHLsieQEIRDQKERCDKSLTTIMELQQRIQES 1292
Cdd:TIGR00618  509 SCIHPNPARQDIDNPGPLTRRMQRGEQTyAQLETSEEDVYHQLTSERKQR---ASLKEQMQEIQQSFSILTQCDNRSKED 585

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568962150  1293 AKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLA 1353
Cdd:TIGR00618  586 IPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLT 646
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
474-685 8.51e-06

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 50.40  E-value: 8.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  474 ERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQthflalKEHL---TNEAATGSHRIIEELREQLKDLKGKYEGASA 550
Cdd:COG3206   167 ELRREEARKALEFLEEQLPELRKELEEAEAALEEFR------QKNGlvdLSEEAKLLLQQLSELESQLAEARAELAEAEA 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  551 EVGKLRSQIKQSEMLVGEFKRDEG--RLVEENKRLQKEcgtcEVELERRGR----RVVELEGQLKELGAKLA-------- 616
Cdd:COG3206   241 RLAALRAQLGSGPDALPELLQSPViqQLRAQLAELEAE----LAELSARYTpnhpDVIALRAQIAALRAQLQqeaqrila 316

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  617 -LSVPTEKFESMKSSLSNDINEKVKRLAEVGRdyesAQGEIRQLKRDLESVRAQhirpeeHEQLRSRLEQ 685
Cdd:COG3206   317 sLEAELEALQAREASLQAQLAQLEARLAELPE----LEAELRRLEREVEVAREL------YESLLQRLEE 376
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1132-1378 1.66e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.99  E-value: 1.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1132 EREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEvgimkasLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETRE 1211
Cdd:COG4942    20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQ-------LAALERRIAALARRIRALEQELAALEAELAELEKEI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1212 vvdmskyKATKNDLETQISNLNDKLASLNRKYDQACEE-KVSAKDEKELLHLS--IEQEIRDQKERCDKSLTTIMELQQR 1288
Cdd:COG4942    93 -------AELRAELEAQKEELAELLRALYRLGRQPPLAlLLSPEDFLDAVRRLqyLKYLAPARREQAEELRADLAELAAL 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1289 IQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYRT 1368
Cdd:COG4942   166 RAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245

                         250
                  ....*....|
gi 568962150 1369 HLLSAAQGHM 1378
Cdd:COG4942   246 AGFAALKGKL 255
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1053-1280 1.81e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.61  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1053 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEilaaqnllqkqpvpLEQVEALKKSLNGTIEQLKEELRSKQRCLE 1132
Cdd:COG4942    21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQ--------------LAALERRIAALARRIRALEQELAALEAELA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1133 REQQTVSQLQQLLENQKN-------SSVTLAEHLKLKEALE----KEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTK 1201
Cdd:COG4942    87 ELEKEIAELRAELEAQKEelaellrALYRLGRQPPLALLLSpedfLDAVRRLQYLKYLAPARREQAEELRADLAELAALR 166

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568962150 1202 QALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERCDKSLT 1280
Cdd:COG4942   167 AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPA 245
PRK12704 PRK12704
phosphodiesterase; Provisional
 1062-1218 1.91e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 49.01  E-value: 1.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1062 KDLSQKYSDVKSEREKLVEEKAKQASE-----ILAAQNLLQKQpvpLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQ 1136
Cdd:PRK12704   27 KIAEAKIKEAEEEAKRILEEAKKEAEAikkeaLLEAKEEIHKL---RNEFEKELRERRNELQKLEKRLLQKEENLDRKLE 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1137 TVSQLQQLLENQKNSSvtlaehlklkEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEvQTTKQALKNLETREVVDMS 1216
Cdd:PRK12704  104 LLEKREEELEKKEKEL----------EQKQQELEKKEEELEELIEEQLQELERISGLTAE-EAKEILLEKVEEEARHEAA 172


                  ..
gi 568962150 1217 KY 1218
Cdd:PRK12704  173 VL 174
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
 962-1352 2.22e-05

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 48.53  E-value: 2.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   962 ELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVK-------KGKQENERLRADLAALQKELQ 1034
Cdd:pfam19220   21 DLRSLKADFSQLIEPIEAILRELPQAKSRLLELEALLAQERAAYGKLRRELAgltrrlsAAEGELEELVARLAKLEAALR 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1035 DRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLN 1114
Cdd:pfam19220  101 EAEAAKEELRIELRDKTAQAEALERQLAAETEQNRALEEENKALREEAQAAEKALQRAEGELATARERLALLEQENRRLQ 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1115 GTIEQLKEELRSKQRCL-EREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMK---ASLREKEEESQKKTKEV 1190
Cdd:pfam19220  181 ALSEEQAAELAELTRRLaELETQLDATRARLRALEGQLAAEQAERERAEAQLEEAVEAHRaerASLRMKLEALTARAAAT 260

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1191 SKLQTEVQTtkqalknletrevvdmskykatkndletqisNLNDKLASLnRKYDQACEEKVSAKDEKELLHLSIEQEIRD 1270
Cdd:pfam19220  261 EQLLAEARN-------------------------------QLRDRDEAI-RAAERRLKEASIERDTLERRLAGLEADLER 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1271 QKERCDKSLTTIMELQQRIQESAKQIEAKDNKitellndverLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQ 1350
Cdd:pfam19220  309 RTQQFQEMQRARAELEERAEMLTKALAAKDAA----------LERAEERIASLSDRIAELTKRFEVERAALEQANRRLKE 378


                   ..
gi 568962150  1351 QL 1352
Cdd:pfam19220  379 EL 380
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 523-732 2.38e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 48.22  E-value: 2.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  523 AATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELERRGRRVV 602
Cdd:COG4942    14 AAAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  603 ELEGQLKELGAKLALSVPTEKFESMKSSL-----SNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPE--- 674
Cdd:COG4942    94 ELRAELEAQKEELAELLRALYRLGRQPPLalllsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEaer 173

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568962150  675 --------EHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTR 732
Cdd:COG4942   174 aeleallaELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAA 239
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
870-1368 2.61e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 48.76  E-value: 2.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  870 RALLEAKKRFDDTSQEVSKLRDENEVLRRnLENVQNQMKADYVSLEEHSRRMSTV-----SQSLKEAQEANAAILADHRQ 944
Cdd:COG4913   228 DALVEHFDDLERAHEALEDAREQIELLEP-IRELAERYAAARERLAELEYLRAALrlwfaQRRLELLEAELEELRAELAR 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  945 GQEEIVSLHAEIKAQKKELDTIQEciKLKYAPLARLEECERKFKAtekgLKEQLSEQTHKCRQRDEEVKKGKQENERLRA 1024
Cdd:COG4913   307 LEAELERLEARLDALREELDELEA--QIRGNGGDRLEQLEREIER----LERELEERERRRARLEALLAALGLPLPASAE 380

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1025 DLAALQKELQDRnalaeeareaeralsgkADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEIlaaQNLLQKQ---PV 1101
Cdd:COG4913   381 EFAALRAEAAAL-----------------LEALEEELEALEEALAEAEAALRDLRRELRELEAEI---ASLERRKsniPA 440

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1102 PLEQV-EALKKSLNGTIEQLK---E--ELRSKQ-----------------------------RCLEREQQT-------VS 1139
Cdd:COG4913   441 RLLALrDALAEALGLDEAELPfvgEliEVRPEEerwrgaiervlggfaltllvppehyaaalRWVNRLHLRgrlvyerVR 520

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1140 QLQQLLENQKNSSVTLAEHLKLKE-----ALEKEV-------------------------GIMKASLREKEEESQKKTKE 1189
Cdd:COG4913   521 TGLPDPERPRLDPDSLAGKLDFKPhpfraWLEAELgrrfdyvcvdspeelrrhpraitraGQVKGNGTRHEKDDRRRIRS 600

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1190 VSKLQtevQTTKQALKNLETRevvdMSKYKATKNDLETQISNLNDKLASLNRKYDQAceEKVSAKDEKELLHLSIEQEIR 1269
Cdd:COG4913   601 RYVLG---FDNRAKLAALEAE----LAELEEELAEAEERLEALEAELDALQERREAL--QRLAEYSWDEIDVASAEREIA 671

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1270 ---DQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLtyssgspTKRQSQLVDTLQQRVR 1346
Cdd:COG4913   672 eleAELERLDASSDDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEE-------LDELQDRLEAAEDLAR 744

                         570       580
                  ....*....|....*....|..
gi 568962150 1347 DLQQQLADADRQHQEVIAIYRT 1368
Cdd:COG4913   745 LELRALLEERFAAALGDAVERE 766
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1053-1258 2.72e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 48.29  E-value: 2.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1053 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQpvpLEQVEALKKSLNGTIEQLKEELRSKQRcle 1132
Cdd:COG3883    24 ELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKL---QAEIAEAEAEIEERREELGERARALYR--- 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1133 rEQQTVSQLQQLLENQKNSSVtlaehlklkealekevgIMKASLREKEEESQKKT-KEVSKLQTEVQTTKQALKNLETRE 1211
Cdd:COG3883    98 -SGGSVSYLDVLLGSESFSDF-----------------LDRLSALSKIADADADLlEELKADKAELEAKKAELEAKLAEL 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 568962150 1212 VVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKE 1258
Cdd:COG3883   160 EALKAELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELA 206
Ank_2 pfam12796
Ankyrin repeats (3 copies);
25-85 2.94e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 43.95  E-value: 2.94e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568962150    25 LMKAAERGDVEKVSSILAKKGVhpgKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRD 85
Cdd:pfam12796   34 LHLAAKNGHLEIVKLLLEHADV---NLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 92-220 2.97e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.47  E-value: 2.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   92 LHLAAKYGHALCLQKLLQYNcpteHVDLQ-----GRTALHDAAMADCPSSIQLLCDhgasvNAKDI----------DGRT 156
Cdd:cd22192    21 LLLAAKENDVQAIKKLLKCP----SCDLFqrgalGETALHVAALYDNLEAAVVLME-----AAPELvnepmtsdlyQGET 91

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568962150  157 PLVLATQMCRPTICQLLIDRGADVNSRD------KQNRTALMLGCEY--------GCRDAVEVLVKNGADLTLLDALG 220
Cdd:cd22192    92 ALHIAVVNQNLNLVRELIARGADVVSPRatgtffRPGPKNLIYYGEHplsfaacvGNEEIVRLLIEHGADIRAQDSLG 169
46 PHA02562
endonuclease subunit; Provisional
 707-971 3.38e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 48.09  E-value: 3.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  707 DVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQR----YTEKKQEAERLLAENDKLT 782
Cdd:PHA02562  161 DISVLSEMDKLNKDKIRELNQQIQTLDMKIDHIQQQIKTYNKNIEEQRKKNGENIARkqnkYDELVEEAKTIKAEIEELT 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  783 knvSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKcgegqekirALMSENSSLKKTLSSQYvpaKTHEEVKASLN 862
Cdd:PHA02562  241 ---DELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQKV---------IKMYEKGGVCPTCTQQI---SEGPDRITKIK 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  863 STVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLrRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADH 942
Cdd:PHA02562  306 DKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKL-LELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKL 384

                         250       260
                  ....*....|....*....|....*....
gi 568962150  943 RQGQEEIVSLHAEIKAQKKELDTIQECIK 971
Cdd:PHA02562  385 QDELDKIVKTKSELVKEKYHRGIVTDLLK 413
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 774-1036 4.33e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.45  E-value: 4.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  774 LLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRAlmsensslkktlssqyvpakt 853
Cdd:COG4942    15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRA--------------------- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  854 heevkasLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDEnevLRRNLENVQNQMKADYVSL---EEHSRRMSTVSQSLKE 930
Cdd:COG4942    74 -------LEQELAALEAELAELEKEIAELRAELEAQKEE---LAELLRALYRLGRQPPLALllsPEDFLDAVRRLQYLKY 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  931 AQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIqeciklkyapLARLEECERKFKATEKGLKEQLSEQTHKCRQRDE 1010
Cdd:COG4942   144 LAPARREQAEELRADLAELAALRAELEAERAELEAL----------LAELEEERAALEALKAERQKLLARLEKELAELAA 213

                         250       260
                  ....*....|....*....|....*.
gi 568962150 1011 EVKKGKQENERLRADLAALQKELQDR 1036
Cdd:COG4942   214 ELAELQQEAEELEALIARLEAEAAAA 239
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 485-1367 4.65e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 48.25  E-value: 4.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   485 KQLEDALKDVQKRMYESEGKVKQMQThfLALKEHLTNEAATGSHRIIEELREQLKDLKGKYEGASAEvgkLRSQIKQSEM 564
Cdd:pfam01576  155 KLLEERISEFTSNLAEEEEKAKSLSK--LKNKHEAMISDLEERLKKEEKGRQELEKAKRKLEGESTD---LQEQIAELQA 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   565 LVGEFKrdeGRLVEENKRLQKECGTCEVELERRG---RRVVELEGQLKELGAKLALS-VPTEKFESMKSSLSNDInEKVK 640
Cdd:pfam01576  230 QIAELR---AQLAKKEEELQAALARLEEETAQKNnalKKIRELEAQISELQEDLESErAARNKAEKQRRDLGEEL-EALK 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   641 RLAEVGRDYESAQGEIR--------QLKRDLESVRAQHirPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLH 712
Cdd:pfam01576  306 TELEDTLDTTAAQQELRskreqevtELKKALEEETRSH--EAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALE 383

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   713 ADNKllnqqvhSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVF 792
Cdd:pfam01576  384 SENA-------ELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKN 456

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   793 VapeKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLKKTLSSQyvpakthEEVKASLNSTVEKTNRAL 872
Cdd:pfam01576  457 I---KLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQEQLEEE-------EEAKRNVERQLSTLQAQL 526

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   873 LEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMK---ADYVSLEEHSRRMSTVSQSLKEAQEANAAILA--------- 940
Cdd:pfam01576  527 SDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEekaAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSnlekkqkkf 606

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   941 DHRQGQEEIVSLH-------AEIKAQKKELDTIQECIKLKYAPLARlEECERKFKATEKGLKEQLSEQ--THKCRQRDEE 1011
Cdd:pfam01576  607 DQMLAEEKAISARyaeerdrAEAEAREKETRALSLARALEEALEAK-EELERTNKQLRAEMEDLVSSKddVGKNVHELER 685

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1012 VKKG-KQENERLRADLAALQKELQD---------------RNALAEEAREAERALSGKADELSKQLKDLsqkysdvkser 1075
Cdd:pfam01576  686 SKRAlEQQVEEMKTQLEELEDELQAtedaklrlevnmqalKAQFERDLQARDEQGEEKRRQLVKQVREL----------- 754

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1076 EKLVEEKAKQASEILAAQNLLQKQPVPLE-QVEALKKSLNGTIEQLKE---ELRSKQRCLEREQQTVSQ-LQQLLENQKN 1150
Cdd:pfam01576  755 EAELEDERKQRAQAVAAKKKLELDLKELEaQIDAANKGREEAVKQLKKlqaQMKDLQRELEEARASRDEiLAQSKESEKK 834

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1151 SSVTLAEHLKLKEALekevgimKASLREKEEESQkktkEVSKLQTEVQ---TTKQALKNLETREVVDMSKYKATKNDLET 1227
Cdd:pfam01576  835 LKNLEAELLQLQEDL-------AASERARRQAQQ----ERDELADEIAsgaSGKSALQDEKRRLEARIAQLEEELEEEQS 903

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1228 QISNLNDKLASLNRKYDQ-----ACEEKVSAKDEKELLHLsiEQEIRDQKERCD--------KSLTTIMELQQRIQESAK 1294
Cdd:pfam01576  904 NTELLNDRLRKSTLQVEQlttelAAERSTSQKSESARQQL--ERQNKELKAKLQemegtvksKFKSSIAALEAKIAQLEE 981

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568962150  1295 QIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYR 1367
Cdd:pfam01576  982 QLEQESRERQAANKLVRRTEKKLKEVLLQVEDERRHADQYKDQAEKGNSRMKQLKRQLEEAEEEASRANAARR 1054
COG5022 COG5022
Myosin heavy chain [General function prediction only];
947-1318 5.20e-05

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 48.15  E-value: 5.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  947 EEIVSLHAEIKAQKKELDTIQECIKLKYAPLarLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKK----GKQENERL 1022
Cdd:COG5022   817 ACIIKLQKTIKREKKLRETEEVEFSLKAEVL--IQKFGRSLKAKKRFSLLKKETIYLQSAQRVELAERqlqeLKIDVKSI 894

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1023 rADLAALQKELQDrnalaeeareaeralsgKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVP 1102
Cdd:COG5022   895 -SSLKLVNLELES-----------------EIIELKKSLSSDLIENLEFKTELIARLKKLLNNIDLEEGPSIEYVKLPEL 956

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1103 LEqvealkksLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVgimkASLREKEEE 1182
Cdd:COG5022   957 NK--------LHEVESKLKETSEEYEDLLKKSTILVREGNKANSELKNFKKELAELSKQYGALQEST----KQLKELPVE 1024

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1183 SQKKTKEVSKLQTEvQTTKQALKNLETREVVDMSKYKAT-KNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLH 1261
Cdd:COG5022  1025 VAELQSASKIISSE-STELSILKPLQKLKGLLLLENNQLqARYKALKLRRENSLLDDKQLYQLESTENLLKTINVKDLEV 1103

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568962150 1262 LSIEQEIRDQKERCDKSLTTIMELQQRIQESAKQ----IEAKDNKITELLNDVERLKQALN 1318
Cdd:COG5022  1104 TNRNLVKPANVLQFIVAQMIKLNLLQEISKFLSQlvntLEPVFQKLSVLQLELDGLFWEAN 1164
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 171-252 7.40e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.20  E-value: 7.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  171 QLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNLLKTASENTNKGG 250
Cdd:PTZ00322   99 RILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELG 178


                  ..
gi 568962150  251 GR 252
Cdd:PTZ00322  179 AN 180
Ank_4 pfam13637
Ankyrin repeats (many copies);
88-140 7.72e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.49  E-value: 7.72e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568962150    88 GRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLL 140
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
AAA_13 pfam13166
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ...
 628-1035 8.86e-05

AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. This family includes the PrrC protein that is thought to be the active component of the anticodon nuclease.


Pssm-ID: 463796 [Multi-domain]  Cd Length: 712  Bit Score: 46.98  E-value: 8.86e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   628 KSSLSNDI-----NEKVKRLAEVGRDYESAQGE-IRQLKRDL--ESVRAQ-HIRP-----EEHEQLRSRLEQKSGELGKK 693
Cdd:pfam13166   29 KTTLSRLLrslelGEPHPKFANGKFEWTNGQPLdIRVFNRDFveENLSEQgEIKPiftlgEESIEIQEKIAKLKKEIKDH 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   694 VSELTLKNQTLQ---KDVEKLHAD-NKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVnvEDLNKKLSEATQRYTEKKQ 769
Cdd:pfam13166  109 EEKLDAAEANLQkldKEKEKLEADfLDECWKKIKRKKNSALSEALNGFKYEANFKSRLL--REIEKDNFNAGVLLSDEDR 186

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   770 EA------ERLLAENDKLTKNVSRLEAVFVAPEKHEKeLMGLKSNIAELKKQLSeLNKKCGEGQEKIRALMSE------- 836
Cdd:pfam13166  187 KAalatvfSDNKPEIAPLTFNVIDFDALEKAEILIQK-VIGKSSAIEELIKNPD-LADWVEQGLELHKAHLDTcpfcgqp 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   837 -NSSLKKTLSSQYvpAKTHEEVKASLNSTVEKTNRALLEAKKRFD---DTSQEVSKLRDENEVLRRNLENVQNQMKADYV 912
Cdd:pfam13166  265 lPAERKAALEAHF--DDEFTEFQNRLQKLIEKVESAISSLLAQLPavsDLASLLSAFELDVEDIESEAEVLNSQLDGLRR 342

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   913 SLEEHSRRMSTVSQ---------SLKEAQEANAAILADHrqgqEEIVSLHAEIKAQKK---ELDTIQECiklkYAPLARL 980
Cdd:pfam13166  343 ALEAKRKDPFKSIEldsvdakieSINDLVASINELIAKH----NEITDNFEEEKNKAKkklRLHLVEEF----KSEIDEY 414

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 568962150   981 EECERKFKATEKGLKEQLSEQTHKCRQRDEEVKkgkqenerlradlaALQKELQD 1035
Cdd:pfam13166  415 KDKYAGLEKAINSLEKEIKNLEAEIKKLREEIK--------------ELEAQLRD 455
Ank_5 pfam13857
Ankyrin repeats (many copies);
40-95 9.32e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.56  E-value: 9.32e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568962150    40 ILAKKGVHPGKLDVEGRSAFHVVASKGNLECLNAILTHGIDVATRDSAGRNALHLA 95
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_5 pfam13857
Ankyrin repeats (many copies);
173-220 1.11e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.18  E-value: 1.11e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 568962150   173 LIDRG-ADVNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALG 220
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEG 49
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 292-1208 1.17e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 46.96  E-value: 1.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   292 EIENEDLREKLRKIQQEQRILLdkvnglqlQLNEEVMVADDLESEREKLKSLLAAKEKQ----HEESLRTIEALKNRfky 367
Cdd:TIGR00606  244 ENELDPLKNRLKEIEHNLSKIM--------KLDNEIKALKSRKKQMEKDNSELELKMEKvfqgTDEQLNDLYHNHQR--- 312

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   368 fESDHPGPGSYPSNRKEDMLHKQGQMYTTE----------PQCASPGIPPHMHSRSMLRpLELSLPSQTSYSENE-ILKK 436
Cdd:TIGR00606  313 -TVREKERELVDCQRELEKLNKERRLLNQEktellveqgrLQLQADRHQEHIRARDSLI-QSLATRLELDGFERGpFSER 390

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   437 ELETLRTYYDSAKQDRLKFQNELAHKVAECKALAlecervkedsDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALK 516
Cdd:TIGR00606  391 QIKNFHTLVIERQEDEAKTAAQLCADLQSKERLK----------QEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVI 460

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   517 EHLTNeAATGSHRIIE---ELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLvgEFKRDEGRLVEENKRLQKEcGTCEVE 593
Cdd:TIGR00606  461 KELQQ-LEGSSDRILEldqELRKAERELSKAEKNSLTETLKKEVKSLQNEKA--DLDRKLRKLDQEMEQLNHH-TTTRTQ 536

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   594 LERRGRRVVELEGQLK--------ELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLES 665
Cdd:TIGR00606  537 MEMLTKDKMDKDEQIRkiksrhsdELTSLLGYFPNKKQLEDWLHSKSKEINQTRDRLAKLNKELASLEQNKNHINNELES 616

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   666 VRAQHIRPEEHEQLRSRLEQKSGELGKKVSELtlknQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKS 745
Cdd:TIGR00606  617 KEEQLSSYEDKLFDVCGSQDEESDLERLKEEI----EKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAE 692

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   746 HDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFvapEKHEKELMGLKSNIAELKKQLSELNKKCGE 825
Cdd:TIGR00606  693 LQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSII---DLKEKEIPELRNKLQKVNRDIQRLKNDIEE 769

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   826 GQEKIRALMSENSSLKKTLSSQYVPAKTHEEVK------ASLNSTVEKTN--RALLEAKKRFDDTSQEVSKLRDENEVLR 897
Cdd:TIGR00606  770 QETLLGTIMPEEESAKVCLTDVTIMERFQMELKdverkiAQQAAKLQGSDldRTVQQVNQEKQEKQHELDTVVSKIELNR 849

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   898 RNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQeanaailadhrQGQEEIVSLHAEIKAQKKEldtiqecIKLKYAPL 977
Cdd:TIGR00606  850 KLIQDQQEQIQHLKSKTNELKSEKLQIGTNLQRRQ-----------QFEEQLVELSTEVQSLIRE-------IKDAKEQD 911

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   978 ARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRnalaeEAREAERALSGKADEL 1057
Cdd:TIGR00606  912 SPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDD-----YLKQKETELNTVNAQL 986

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1058 SKQLKDLSQKYSDVKSEREKLveEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKeelrskqrcLEREQQT 1137
Cdd:TIGR00606  987 EECEKHQEKINEDMRLMRQDI--DTQKIQERWLQDNLTLRKRENELKEVEEELKQHLKEMGQMQ---------VLQMKQE 1055

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568962150  1138 VSQLQQLLENQKNSSVTLAEHLKlkeALEKEVGIMKASLREKeeESQKKTKEVSKLQTEVQTTKQALKNLE 1208
Cdd:TIGR00606 1056 HQKLEENIDLIKRNHVLALGRQK---GYEKEIKHFKKELREP--QFRDAEEKYREMMIVMRTTELVNKDLD 1121
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1087-1239 1.24e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 45.30  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1087 SEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSsvtLAEHLKLKE--A 1164
Cdd:COG1579    17 SELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ---LGNVRNNKEyeA 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568962150 1165 LEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLASL 1239
Cdd:COG1579    94 LQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELEAEREEL 168
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
 754-1189 1.26e-04

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 46.69  E-value: 1.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   754 NKKLSEATQRYTEKKQ-EAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKira 832
Cdd:pfam18971  412 NTKLDNLSEKEKEKFQnEIEDFQKDSKAYLDALGNDRIAFVSKKDTKHSALITEFNNGDLSYTLKDYGKKADKALDR--- 488

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   833 lmSENSSLKKTLSSQ---YVPAKTHEEVKASLNST--VEKTNR-ALLEAKkrFDDTSqeVSKLRDENEV-----LRRNLE 901
Cdd:pfam18971  489 --EKNVTLQGSLKHDgvmFVDYSNFKYTNASKNPNkgVGATNGvSHLEAG--FNKVA--VFNLPDLNNLaitsfVRRNLE 562

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   902 NvqnQMKADYVSLEEHSRRMSTVSQSLKEAqeANAAILADHRQGQEEIVSLHAEIKAQKKELD-TIQECIKLKyaplarl 980
Cdd:pfam18971  563 N---KLTAKGLSLQEANKLIKDFLSSNKEL--AGKALNFNKAVAEAKSTGNYDEVKKAQKDLEkSLRKREHLE------- 630

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   981 EECERKFKaTEKGLKEQLSEQTHKCRQRDEEVKK-GKQENERLRA-----DLAALQKELQDrnalaeeareaeralsgKA 1054
Cdd:pfam18971  631 KEVEKKLE-SKSGNKNKMEAKAQANSQKDEIFALiNKEANRDARAiaytqNLKGIKRELSD-----------------KL 692

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1055 DELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLN----------GTIEQLKEEL 1124
Cdd:pfam18971  693 EKISKDLKDFSKSFDEFKNGKNKDFSKAEETLKALKGSVKDLGINPEWISKVENLNAALNefkngknkdfSKVTQAKSDL 772

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568962150  1125 RSKQRCLEREQQTVSQLQQLlenqkNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKE 1189
Cdd:pfam18971  773 ENSVKDVIINQKVTDKVDNL-----NQAVSVAKAMGDFSRVEQVLADLKNFSKEQLAQQAQKNED 832
Ank_4 pfam13637
Ankyrin repeats (many copies);
21-71 1.55e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 1.55e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568962150    21 YDDRLMKAAERGDVEKVSSILaKKGVHPGKLDVEGRSAFHVVASKGNLECL 71
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLL-EKGADINAVDGNGETALHFAASNGNVEVL 50
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
 752-1258 1.65e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 46.10  E-value: 1.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  752 DLNKKLSEATQRYTEKKQEAerlLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKcGEGQEKIR 831
Cdd:COG5185   111 NYEWSADILISLLYLYKSEI---VALKDELIKVEKLDEIADIEASYGEVETGIIKDIFGKLTQELNQNLKK-LEIFGLTL 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  832 ALMSENSSLKKTLSSQYVPAK----THEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQM 907
Cdd:COG5185   187 GLLKGISELKKAEPSGTVNSIkeseTGNLGSESTLLEKAKEIINIEEALKGFQDPESELEDLAQTSDKLEKLVEQNTDLR 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  908 KADYVSLEEHSRRMStvsqslkeaqEANAAILADHRQGQEEIVSLHAEIKAQKKeldtiQECIKLKYAPLARLEECERKF 987
Cdd:COG5185   267 LEKLGENAESSKRLN----------ENANNLIKQFENTKEKIAEYTKSIDIKKA-----TESLEEQLAAAEAEQELEESK 331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  988 KATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRAdlaalqkelqdrnalaeeareaeralsgkadelSKQLKDLSQK 1067
Cdd:COG5185   332 RETETGIQNLTAEIEQGQESLTENLEAIKEEIENIVG---------------------------------EVELSKSSEE 378

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1068 YSDVKSEREKLVEEkakqasEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKqrclEREQQTVSQLQQLLEN 1147
Cdd:COG5185   379 LDSFKDTIESTKES------LDEIPQNQRGYAQEILATLEDTLKAADRQIEELQRQIEQA----TSSNEEVSKLLNELIS 448

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1148 QKNSSVTLAEHLKLKEALEKEVGIMkaslREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVdmsKYKATKNDLET 1227
Cdd:COG5185   449 ELNKVMREADEESQSRLEEAYDEIN----RSVRSKKEDLNEELTQIESRVSTLKATLEKLRAKLER---QLEGVRSKLDQ 521

                         490       500       510
                  ....*....|....*....|....*....|.
gi 568962150 1228 QISNLNDKLASLNRKYDQACEEKVSAKDEKE 1258
Cdd:COG5185   522 VAESLKDFMRARGYAHILALENLIPASELIQ 552
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 892-1282 1.92e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 45.88  E-value: 1.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   892 ENEVLRRNLENVQNQMKADYVSLEEHSRRMStvSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIK 971
Cdd:pfam17380  267 ENEFLNQLLHIVQHQKAVSERQQQEKFEKME--QERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQAAIYAEQERMAM 344

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   972 LKYAPLARLEECERKfKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAAlqkelqdrnalaeeareaerals 1051
Cdd:pfam17380  345 ERERELERIRQEERK-RELERIRQEEIAMEISRMRELERLQMERQQKNERVRQELEA----------------------- 400

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1052 gkadelskqlkdlSQKYSDVKSEREKLVEEKAKQASEILAAQ-NLLQKQPVPLEQvealkkslngtiEQLKEELRSKQRC 1130
Cdd:pfam17380  401 -------------ARKVKILEEERQRKIQQQKVEMEQIRAEQeEARQREVRRLEE------------ERAREMERVRLEE 455

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1131 LEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETR 1210
Cdd:pfam17380  456 QERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERR 535

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568962150  1211 EVVDMSKYKATKNDLETQISNlNDKLASLNRKYDQACEEkvsakdEKELLHLSIEQEIRDQKERCDKSLTTI 1282
Cdd:pfam17380  536 REAEEERRKQQEMEERRRIQE-QMRKATEERSRLEAMER------EREMMRQIVESEKARAEYEATTPITTI 600
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 914-1154 1.95e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.53  E-value: 1.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  914 LEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEeceRKFKATEKG 993
Cdd:COG4942    29 LEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR---AELEAQKEE 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  994 LKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREaeralsgKADELSKQLKDLSQKYSDVKS 1073
Cdd:COG4942   106 LAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRA-------DLAELAALRAELEAERAELEA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1074 EREKLVEEKAKQASEILAAQNLLQKqpvpleqvealkksLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSV 1153
Cdd:COG4942   179 LLAELEEERAALEALKAERQKLLAR--------------LEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244


                  .
gi 568962150 1154 T 1154
Cdd:COG4942   245 A 245
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 794-1035 1.95e-04

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 45.69  E-value: 1.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  794 APEKHEK-ELMGLKSNIAELKKQLSELN------KKCGEGQEKIRALMSENSSLKKTLS--SQYVPA-----KTHEEVK- 858
Cdd:PRK05771    2 APVRMKKvLIVTLKSYKDEVLEALHELGvvhiedLKEELSNERLRKLRSLLTKLSEALDklRSYLPKlnplrEEKKKVSv 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  859 ASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADY-VSLEEHSRRMSTVSQSLKEAQEANAa 937
Cdd:PRK05771   82 KSLEELIKDVEEELEKIEKEIKELEEEISELENEIKELEQEIERLEPWGNFDLdLSLLLGFKYVSVFVGTVPEDKLEEL- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  938 iladhrqgQEEIVSLHAEIKAQKKELDTI-----QECIKLKYAPLARLEEceRKFKATEKGLkeqLSEQTHKCRQRDEEV 1012
Cdd:PRK05771  161 --------KLESDVENVEYISTDKGYVYVvvvvlKELSDEVEEELKKLGF--ERLELEEEGT---PSELIREIKEELEEI 227

                         250       260
                  ....*....|....*....|...
gi 568962150 1013 KKgkqENERLRADLAALQKELQD 1035
Cdd:PRK05771  228 EK---ERESLLEELKELAKKYLE 247
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
506-725 1.98e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.06  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  506 KQMQTHFLALKEHLTNeaATGSHRIIEELREQLKDLKG------KYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEE 579
Cdd:COG4913   221 PDTFEAADALVEHFDD--LERAHEALEDAREQIELLEPirelaeRYAAARERLAELEYLRAALRLWFAQRRLELLEAELE 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  580 N-----KRLQKECGTCEVELERRGRRVVELEGQLKELGAKLalsvptekfesmKSSLSNDINEKVKRLAEVGRDYESAQG 654
Cdd:COG4913   299 ElraelARLEAELERLEARLDALREELDELEAQIRGNGGDR------------LEQLEREIERLERELEERERRRARLEA 366

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568962150  655 EIRQLK-------RDLESVRAQ-HIRPEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSL 725
Cdd:COG4913   367 LLAALGlplpasaEEFAALRAEaAALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLAL 445
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 104-247 2.02e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 45.72  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  104 LQKLLQY--NCPTEHVDlQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGAD-- 179
Cdd:PHA02874   17 IEKIIKNkgNCINISVD-ETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGVDts 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  180 ---------------------VNSRDKQNRTALMLGCEYGCRDAVEVLVKNGADLTLLDALGHDSSYYARIGDNLDILNL 238
Cdd:PHA02874   96 ilpipciekdmiktildcgidVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKL 175

                         170
                  ....*....|.
gi 568962150  239 L--KTASENTN 247
Cdd:PHA02874  176 LleKGAYANVK 186
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 153-185 2.07e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 2.07e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568962150   153 DGRTPLVLATQMC-RPTICQLLIDRGADVNSRDK 185
Cdd:pfam00023    1 DGNTPLHLAAGRRgNLEIVKLLLSKGADVNARDK 34
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 93-173 2.30e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.66  E-value: 2.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   93 HLAAKyGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQL 172
Cdd:PTZ00322   88 QLAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQL 166


                  .
gi 568962150  173 L 173
Cdd:PTZ00322  167 L 167
Ank_5 pfam13857
Ankyrin repeats (many copies);
74-126 2.30e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.41  E-value: 2.30e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568962150    74 ILTHG-IDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALH 126
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 446-1034 2.49e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 45.48  E-value: 2.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   446 DSAKQDRLKFQNELAHKVAECKALALECERVKEDSDEQIKQLEDALKDVQKRmYESEGKVKQMQTHFLALKEHLTNEAAT 525
Cdd:pfam05483  179 EETRQVYMDLNNNIEKMILAFEELRVQAENARLEMHFKLKEDHEKIQHLEEE-YKKEINDKEKQVSLLLIQITEKENKMK 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   526 GSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECgtcEVELERRGRRVVELE 605
Cdd:pfam05483  258 DLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDL---QIATKTICQLTEEKE 334

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   606 GQLKELG-AKLALSVPTEKFESMKSSLSNDINEKVKRLaevgrdyESAQGEIRQLKRDLESVRAQHirpEEHEQLRSRLE 684
Cdd:pfam05483  335 AQMEELNkAKAAHSFVVTEFEATTCSLEELLRTEQQRL-------EKNEDQLKIITMELQKKSSEL---EEMTKFKNNKE 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   685 QKSGELGKKVSE---LTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLSEAT 761
Cdd:pfam05483  405 VELEELKKILAEdekLLDEKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEK 484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   762 QRYTEKKQEAERLLAENDKLTKNVSRLEAvfvapekhekELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENSSLK 841
Cdd:pfam05483  485 LKNIELTAHCDKLLLENKELTQEASDMTL----------ELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVR 554

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   842 KTLSSQyvpaktHEEVKASLNSTVEKTNRALLEA-----------------KKRFDDTSQEVSKLRDENEVLRRNLENVQ 904
Cdd:pfam05483  555 EEFIQK------GDEVKCKLDKSEENARSIEYEVlkkekqmkilenkcnnlKKQIENKNKNIEELHQENKALKKKGSAEN 628

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   905 NQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKL----KYAPLARL 980
Cdd:pfam05483  629 KQLNAYEIKVNKLELELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADEAVKLQKEIDKrcqhKIAEMVAL 708

                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 568962150   981 EECERkfKATEKGLKEQLSE-QTHKCRQRDEEVKKGKQENE--RLRADLAALQKELQ 1034
Cdd:pfam05483  709 MEKHK--HQYDKIIEERDSElGLYKNKEQEQSSAKAALEIElsNIKAELLSLKKQLE 763
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 947-1336 2.56e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 45.73  E-value: 2.56e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   947 EEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADL 1026
Cdd:pfam02463  160 EEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERI 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1027 AALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEilaaqnllqkqpvpLEQV 1106
Cdd:pfam02463  240 DLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSE--------------LLKL 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1107 EALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEvgimKASLREKEEESQKK 1186
Cdd:pfam02463  306 ERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEK----LEQLEEELLAKKKL 381

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1187 TKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQ 1266
Cdd:pfam02463  382 ESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLL 461

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1267 EIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQ 1336
Cdd:pfam02463  462 KDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRL 531
Ank_5 pfam13857
Ankyrin repeats (many copies);
107-161 2.70e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.02  E-value: 2.70e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568962150   107 LLQY-NCPTEHVDLQGRTALHDAAMADCPSSIQLLCDHGASVNAKDIDGRTPLVLA 161
Cdd:pfam13857    1 LLEHgPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
mukB PRK04863
chromosome partition protein MukB;
436-1254 2.82e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 45.72  E-value: 2.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  436 KELETLRTYYDSAkqDRLKFQNELAHKVAEckalALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLAL 515
Cdd:PRK04863  260 KHLITESTNYVAA--DYMRHANERRVHLEE----ALELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAA 333

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  516 KEHLT----------------------NEAATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIK--QSEMLVGEFK- 570
Cdd:PRK04863  334 SDHLNlvqtalrqqekieryqadleelEERLEEQNEVVEEADEQQEENEARAEAAEEEVDELKSQLAdyQQALDVQQTRa 413

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  571 ---RDEGRLVEENKRLqkeCGTCEVELERRGRRVVELEGQLKELGAKLaLSVPTekfesmKSSLSNDINEK-------VK 640
Cdd:PRK04863  414 iqyQQAVQALERAKQL---CGLPDLTADNAEDWLEEFQAKEQEATEEL-LSLEQ------KLSVAQAAHSQfeqayqlVR 483

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  641 RLA-EVGRdyESAQGEIRQLKRDLESVRAQhirPEEHEQLRSRLeqksgelgkkvseltlknQTLQKDVEKLHADNKLLN 719
Cdd:PRK04863  484 KIAgEVSR--SEAWDVARELLRRLREQRHL---AEQLQQLRMRL------------------SELEQRLRQQQRAERLLA 540

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  720 Q--QVHSLTVEMKTRYvplrvsEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKN----------VSR 787
Cdd:PRK04863  541 EfcKRLGKNLDDEDEL------EQLQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRLAARapawlaaqdaLAR 614

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  788 LEAVFvaPEK----------------HEKELM----GLKSNIAELKKQLSELNKKCGEGQEKIRALMS-----------E 836
Cdd:PRK04863  615 LREQS--GEEfedsqdvteymqqlleRERELTverdELAARKQALDEEIERLSQPGGSEDPRLNALAErfggvllseiyD 692

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  837 NSSLKKT--LSSQYVPAKtHEEVKASLNSTVEKtnralLEAkkrFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSL 914
Cdd:PRK04863  693 DVSLEDApyFSALYGPAR-HAIVVPDLSDAAEQ-----LAG---LEDCPEDLYLIEGDPDSFDDSVFSVEELEKAVVVKI 763

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  915 EEHSRRMS---TVSQSLKEAQEANAAILadhRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYA----------PLARLE 981
Cdd:PRK04863  764 ADRQWRYSrfpEVPLFGRAAREKRIEQL---RAEREELAERYATLSFDVQKLQRLHQAFSRFIGshlavafeadPEAELR 840

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  982 ECERKFKATEKGLkEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKE-LQDRnalaeeareaeralsgkADELSKQ 1060
Cdd:PRK04863  841 QLNRRRVELERAL-ADHESQEQQQRSQLEQAKEGLSALNRLLPRLNLLADEtLADR-----------------VEEIREQ 902

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1061 LKDLSQKYSDVKSEreklveekAKQASEILAAQNLLQKQPvplEQVEALKKSLngtiEQLKEELR-SKQRCL-------E 1132
Cdd:PRK04863  903 LDEAEEAKRFVQQH--------GNALAQLEPIVSVLQSDP---EQFEQLKQDY----QQAQQTQRdAKQQAFaltevvqR 967

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1133 REQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVgimKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLEtREV 1212
Cdd:PRK04863  968 RAHFSYEDAAEMLAKNSDLNEKLRQRLEQAEQERTRA---REQLRQAQAQLAQYNQVLASLKSSYDAKRQMLQELK-QEL 1043

                         890       900       910       920       930       940       950
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568962150 1213 VDM-----------------------SKYKATKNDLETQIS-------NLNDKLASLNRKYDQACEEKVSAK 1254
Cdd:PRK04863 1044 QDLgvpadsgaeerararrdelharlSANRSRRNQLEKQLTfceaemdNLTKKLRKLERDYHEMREQVVNAK 1115
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 667-1212 3.05e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 45.12  E-value: 3.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   667 RAQHIRPEEH-EQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMKKS 745
Cdd:pfam05557    1 RAELIESKARlSQLQNEKKQMELEHKRARIELEKKASALKRQLDRESDRNQELQKRIRLLEKREAEAEEALREQAELNRL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   746 HDVNVEDLNKKLSEATQRYTEKKqeaERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGE 825
Cdd:pfam05557   81 KKKYLEALNKKLNEKESQLADAR---EVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQLRQN 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   826 GQEKIRALMSENSSLKK---TLSSQYVPAKTHEEVKASLNS--TVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNL 900
Cdd:pfam05557  158 LEKQQSSLAEAEQRIKElefEIQSQEQDSEIVKNSKSELARipELEKELERLREHNKHLNENIENKLLLKEEVEDLKRKL 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   901 ENvQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARL 980
Cdd:pfam05557  238 ER-EEKYREEAATLELEKEKLEQELQSWVKLAQDTGLNLRSPEDLSRRIEQLQQREIVLKEENSSLTSSARQLEKARREL 316

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   981 EECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEareaeralSGKADELSKQ 1060
Cdd:pfam05557  317 EQELAQYLKKIEDLNKKLKRHKALVRRLQRRVLLLTKERDGYRAILESYDKELTMSNYSPQL--------LERIEEAEDM 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1061 LKDLSQKYSDVKSEREKLVEEKAKQAS---------EILAAQNLLQKQPVPLEQVEALKKSLNgTIEQLKEELRSKQRCL 1131
Cdd:pfam05557  389 TQKMQAHNEEMEAQLSVAEEELGGYKQqaqtlerelQALRQQESLADPSYSKEEVDSLRRKLE-TLELERQRLREQKNEL 467

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1132 EREQQTVSqLQQLLENQKNSSVTLAEHLKLK---------EALEKEVGIMKASLREKEEESQK-----------KTKEVS 1191
Cdd:pfam05557  468 EMELERRC-LQGDYDPKKTKVLHLSMNPAAEayqqrknqlEKLQAEIERLKRLLKKLEDDLEQvlrlpettstmNFKEVL 546

                          570       580
                   ....*....|....*....|.
gi 568962150  1192 KLQTEVQTTKqaLKNLETREV 1212
Cdd:pfam05557  547 DLRKELESAE--LKNQRLKEV 565
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1017-1361 3.16e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 3.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1017 QENERLRADLAALQKELQDRnalaeeareaeralsgkADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQnlL 1096
Cdd:COG4913   606 FDNRAKLAALEAELAELEEE-----------------LAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVAS--A 666

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1097 QKQpvpLEQVEALKKSL---NGTIEQLK---EELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLK--LKEALEKE 1168
Cdd:COG4913   667 ERE---IAELEAELERLdasSDDLAALEeqlEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQdrLEAAEDLA 743

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1169 VGIMKASLREK--EEESQKKTKEVSK-LQTEVQTTKQALKNLETREVVDMSKYKAT----KNDLETQISNLNDKLASLNR 1241
Cdd:COG4913   744 RLELRALLEERfaAALGDAVERELREnLEERIDALRARLNRAEEELERAMRAFNREwpaeTADLDADLESLPEYLALLDR 823

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1242 KYDQACEEKVsaKDEKELLHLSIEQEIRDqkercdkslttimeLQQRIQESAKQIEakdnkitellndvERLKQaLN-GL 1320
Cdd:COG4913   824 LEEDGLPEYE--ERFKELLNENSIEFVAD--------------LLSKLRRAIREIK-------------ERIDP-LNdSL 873

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 568962150 1321 SQLTYSSGS-----PTKRQSQLVDTLQQRVRDLQQQLADADRQHQE 1361
Cdd:COG4913   874 KRIPFGPGRylrleARPRPDPEVREFRQELRAVTSGASLFDEELSE 919
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 751-986 3.73e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.37  E-value: 3.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  751 EDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAvfvapekhekelmglksNIAELKKQLSELNKKCGEGQEKI 830
Cdd:COG4942    23 AEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALER-----------------RIAALARRIRALEQELAALEAEL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  831 RALMSENSSLKKTLSSQyvpakthEEVKASLNSTVEKTNR----ALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQ 906
Cdd:COG4942    86 AELEKEIAELRAELEAQ-------KEELAELLRALYRLGRqpplALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRAD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  907 MKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERK 986
Cdd:COG4942   159 LAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAA 238
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 120-151 4.15e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.81  E-value: 4.15e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568962150   120 QGRTALHDAA-MADCPSSIQLLCDHGASVNAKD 151
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARD 33
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 1006-1222 4.30e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.44  E-value: 4.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1006 RQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYsdvkSEREKLVEEKAKQ 1085
Cdd:COG3883    19 QAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEI----EERREELGERARA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1086 ASE----------ILAAQN---LLQKQPVpLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSS 1152
Cdd:COG3883    95 LYRsggsvsyldvLLGSESfsdFLDRLSA-LSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAEL 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568962150 1153 VT-LAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATK 1222
Cdd:COG3883   174 EAqQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 244
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
434-838 4.58e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.76  E-value: 4.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  434 LKKELETLRTYYDSAKQDRLKFQNELAHKVAECKALALECERvkEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQTHFL 513
Cdd:COG4717    93 LQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQEL--EALEAELAELPERLEELEERLEELRELEEELEELEA 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  514 ALKEhLTNEAATGSHRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKEcgtceve 593
Cdd:COG4717   171 ELAE-LQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALE------- 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  594 lerrgRRVVELEGQLKELGAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQH-IR 672
Cdd:COG4717   243 -----ERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQALPALEeLE 317

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  673 PEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQVHSltvemktryvpLRVSEEMKKSHDVNVED 752
Cdd:COG4717   318 EEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEELQLEELE-----------QEIAALLAEAGVEDEEE 386

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  753 LNKKLsEATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVaPEKHEKELMGLKSNIAELKKQLSELNKKCGEGQEKIRA 832
Cdd:COG4717   387 LRAAL-EQAEEYQELKEELEELEEQLEELLGELEELLEALD-EEELEEELEELEEELEELEEELEELREELAELEAELEQ 464


                  ....*.
gi 568962150  833 LMSENS 838
Cdd:COG4717   465 LEEDGE 470
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 458-1145 4.76e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 44.83  E-value: 4.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   458 ELAHKVAECKALA-LECERVKEDSDEQ-IKQLEDALKdvqkRMYESEGKVKQMQThflaLKEHLTNEAATGSHRIIEELR 535
Cdd:pfam12128  222 QVEHWIRDIQAIAgIMKIRPEFTKLQQeFNTLESAEL----RLSHLHFGYKSDET----LIASRQEERQETSAELNQLLR 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   536 EQLKDLKGKYEGASAEVGKLRSQIKQsemlvgefKRDEGRLVEENKR--LQKECGTCEVELERRGRRVVELEGQLKELGA 613
Cdd:pfam12128  294 TLDDQWKEKRDELNGELSAADAAVAK--------DRSELEALEDQHGafLDADIETAAADQEQLPSWQSELENLEERLKA 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   614 KL-ALSVPTEKFESMKSSLSNDINEKVKRLAE--------VGRDYESAQGEIRQLKRDLESVRAQHIRP--EEHEQLRSR 682
Cdd:pfam12128  366 LTgKHQDVTAKYNRRRSKIKEQNNRDIAGIKDklakireaRDRQLAVAEDDLQALESELREQLEAGKLEfnEEEYRLKSR 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   683 LEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKL--LNQQVHSLTVEmktryvpLRVSEEMKKSHDVNVEDLNKKLSEA 760
Cdd:pfam12128  446 LGELKLRLNQATATPELLLQLENFDERIERAREEQeaANAEVERLQSE-------LRQARKRRDQASEALRQASRRLEER 518

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   761 TQRYTEKKQ----EAERLLA--------ENDKLTKNVSR--LEAVFVAPEKHEKELMGlKSNIAELKKQLSELNKKCGEG 826
Cdd:pfam12128  519 QSALDELELqlfpQAGTLLHflrkeapdWEQSIGKVISPelLHRTDLDPEVWDGSVGG-ELNLYGVKLDLKRIDVPEWAA 597

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   827 QEKirALMSENSSLKKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVL---------- 896
Cdd:pfam12128  598 SEE--ELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEkdkknkalae 675

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   897 --------RRNLENVQNQMKADYVSLEEHSRRMS-----TVSQSLKEAQEANAAILADHRQGQE-EIVSLHAEIKAQKKE 962
Cdd:pfam12128  676 rkdsanerLNSLEAQLKQLDKKHQAWLEEQKEQKreartEKQAYWQVVEGALDAQLALLKAAIAaRRSGAKAELKALETW 755

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   963 LDT--------------IQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKcrqRDEEVKKGKQENERLRADLAA 1028
Cdd:pfam12128  756 YKRdlaslgvdpdviakLKREIRTLERKIERIAVRRQEVLRYFDWYQETWLQRRPR---LATQLSNIERAISELQQQLAR 832

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1029 LQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREklVEEKAKQASEILAA-QNLLQKQPVPLEQVE 1107
Cdd:pfam12128  833 LIADTKLRRAKLEMERKASEKQQVRLSENLRGLRCEMSKLATLKEDAN--SEQAQGSIGERLAQlEDLKLKRDYLSESVK 910

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568962150  1108 ALKKSLNGTI------------EQLKEELRS---KQRCLEREQQTVSQLQQLL 1145
Cdd:pfam12128  911 KYVEHFKNVIadhsgsglaetwESLREEDHYqndKGIRLLDYRKLVPYLEQWF 963
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1059-1320 5.09e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 44.67  E-value: 5.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1059 KQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQKQPVPL-EQVEALKKSLNgTIEQLKEELRSKQRCLEREQQT 1137
Cdd:PRK03918  175 KRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELrEELEKLEKEVK-ELEELKEEIEELEKELESLEGS 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1138 VSQLQQLLENQKNSSVTLAEHLKLKEALEKEVgimkaslrekeEESQKKTKEVSKLQTEVQTTKQALKNLETREvvdmSK 1217
Cdd:PRK03918  254 KRKLEEKIRELEERIEELKKEIEELEEKVKEL-----------KELKEKAEEYIKLSEFYEEYLDELREIEKRL----SR 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1218 YKATKNDLETQISNLNDKLASLN--RKYDQACEEKVSAKDEKELLHLSIEQeIRDQKERCDKSLT---------TIMELQ 1286
Cdd:PRK03918  319 LEEEINGIEERIKELEEKEERLEelKKKLKELEKRLEELEERHELYEEAKA-KKEELERLKKRLTgltpeklekELEELE 397

                         250       260       270
                  ....*....|....*....|....*....|....
gi 568962150 1287 QRIQESAKQIEAKDNKITELLNDVERLKQALNGL 1320
Cdd:PRK03918  398 KAKEEIEEEISKITARIGELKKEIKELKKAIEEL 431
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
475-690 5.12e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.37  E-value: 5.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  475 RVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQmqthflalkehltneaatgshriIEELREQLKDLKGKYEGASAEVGK 554
Cdd:COG4717    64 RKPELNLKELKELEEELKEAEEKEEEYAELQEE-----------------------LEELEEELEELEAELEELREELEK 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  555 LRsQIKQSEMLVGEFKRDEGRLVEENKRLQkecgtcevELERRGRRVVELEGQLKELGAKLAlsvptEKFESMKSSLSND 634
Cdd:COG4717   121 LE-KLLQLLPLYQELEALEAELAELPERLE--------ELEERLEELRELEEELEELEAELA-----ELQEELEELLEQL 186

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568962150  635 INEKVKRLAEVGRDYESAQGEIRQLKRDLESVRaqhirpEEHEQLRSRLEQKSGEL 690
Cdd:COG4717   187 SLATEEELQDLAEELEELQQRLAELEEELEEAQ------EELEELEEELEQLENEL 236
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
679-908 5.18e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 44.62  E-value: 5.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  679 LRSRLEQKSGELGKKVSELTLKNQTLQKDVEKlhADNKLlnqqvhsltVEMKTRYVPLRVSEEMKkSHDVNVEDLNKKLS 758
Cdd:COG3206   162 LEQNLELRREEARKALEFLEEQLPELRKELEE--AEAAL---------EEFRQKNGLVDLSEEAK-LLLQQLSELESQLA 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  759 EATQRYTEKKQEAERLlaeNDKLTKNVSRLEAVFVAPEkhekeLMGLKSNIAELKKQLSELNKKCGEGQEKIRALMSENS 838
Cdd:COG3206   230 EARAELAEAEARLAAL---RAQLGSGPDALPELLQSPV-----IQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIA 301

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568962150  839 SLKKTLSSQYVPAKTHEEVK-ASLNSTVEKTNRALLEAKKRFD---DTSQEVSKLRDENEVLRRNLENVQNQMK 908
Cdd:COG3206   302 ALRAQLQQEAQRILASLEAElEALQAREASLQAQLAQLEARLAelpELEAELRRLEREVEVARELYESLLQRLE 375
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 66-187 5.20e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 44.49  E-value: 5.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   66 GNLECLNAILTHgiDVATRDSAGRNALHLAAKYGH-------ALCLQKLLQYNCPTEHVD-------LQGRTALHDAAMA 131
Cdd:cd21882     6 GLLECLRWYLTD--SAYQRGATGKTCLHKAALNLNdgvneaiMLLLEAAPDSGNPKELVNapctdefYQGQTALHIAIEN 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568962150  132 DCPSSIQLLCDHGASVNAKDID-------------GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQN 187
Cdd:cd21882    84 RNLNLVRLLVENGADVSARATGrffrkspgnlfyfGELPLSLAACTNQEEIVRLLLENGAQPAALEAQD 152
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 582-1211 5.83e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 44.40  E-value: 5.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   582 RLQKECGTCEVELERRGRRVVELEGQLKELGAKLA------------LSVPTEKF---ESMKSSLSNdineKVKRLAEVG 646
Cdd:pfam01576    2 RQEEEMQAKEEELQKVKERQQKAESELKELEKKHQqlceeknalqeqLQAETELCaeaEEMRARLAA----RKQELEEIL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   647 RDYESAQGEIRQLKRDLESVR---AQHIRP-----EEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLL 718
Cdd:pfam01576   78 HELESRLEEEEERSQQLQNEKkkmQQHIQDleeqlDEEEAARQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLL 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   719 NQQVHSLTVEMKTRYVPLRVSEEMKKSHDVNVEDLNKKLseatqryteKKQEAERLlaendKLTKNVSRLEAvfvapekh 798
Cdd:pfam01576  158 EERISEFTSNLAEEEEKAKSLSKLKNKHEAMISDLEERL---------KKEEKGRQ-----ELEKAKRKLEG-------- 215

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   799 ekELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMS--------ENSSLKKTLSSQYVPAKTHEEVKAslnstvEKTNR 870
Cdd:pfam01576  216 --ESTDLQEQIAELQAQIAELRAQLAKKEEELQAALArleeetaqKNNALKKIRELEAQISELQEDLES------ERAAR 287

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   871 ALLEAKKRfddtsqevsKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTVSQSLKEAQEANAAILADHRQgqeeiv 950
Cdd:pfam01576  288 NKAEKQRR---------DLGEELEALKTELEDTLDTTAAQQELRSKREQEVTELKKALEEETRSHEAQLQEMRQ------ 352

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   951 slhaeikAQKKELDTIQEciklkyaplaRLEECERKFKATEKGlKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQ 1030
Cdd:pfam01576  353 -------KHTQALEELTE----------QLEQAKRNKANLEKA-KQALESENAELQAELRTLQQAKQDSEHKRKKLEGQL 414

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1031 KELQDRNALAEEAREAERALSGKadeLSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNLLQ---KQPVPL-EQV 1106
Cdd:pfam01576  415 QELQARLSESERQRAELAEKLSK---LQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQeetRQKLNLsTRL 491

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1107 EALKKSLNGTIEQLKEELRSKQRcLEREQQTV-SQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQK 1185
Cdd:pfam01576  492 RQLEDERNSLQEQLEEEEEAKRN-VERQLSTLqAQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDK 570

                          650       660       670
                   ....*....|....*....|....*....|...
gi 568962150  1186 KTKEVSKLQTE-------VQTTKQALKNLETRE 1211
Cdd:pfam01576  571 LEKTKNRLQQElddllvdLDHQRQLVSNLEKKQ 603
PRK11281 PRK11281
mechanosensitive channel MscK;
1221-1358 6.15e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.52  E-value: 6.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1221 TKNDLETQISNLNDklaslnRKYDQAcEEKVSAKD-EKELLHLsieQEIRDQKERCDkslttimELQQRIQESakqieak 1299
Cdd:PRK11281   37 TEADVQAQLDALNK------QKLLEA-EDKLVQQDlEQTLALL---DKIDRQKEETE-------QLKQQLAQA------- 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568962150 1300 DNKITELLNDVERLKQALNGLSQLTYSSGSPTKRQSQLVDTLQQrVRDLQQQLADADRQ 1358
Cdd:PRK11281   93 PAKLRQAQAELEALKDDNDEETRETLSTLSLRQLESRLAQTLDQ-LQNAQNDLAEYNSQ 150
PRK11281 PRK11281
mechanosensitive channel MscK;
806-1026 6.15e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 44.52  E-value: 6.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  806 KSNIAELKKQLSELNKKCGEGQEKIRALMSEN-SSLKKTLSSQYVPaktheevkaSLNSTVEKTNRALLEAKKRFDDT-S 883
Cdd:PRK11281   79 KEETEQLKQQLAQAPAKLRQAQAELEALKDDNdEETRETLSTLSLR---------QLESRLAQTLDQLQNAQNDLAEYnS 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  884 QEVSklrdenevLRRNLENVQNQMKADyvsleehSRRMSTVSQSLKEAQEANAAILADHRQG-QEEIVSLHAEIKAQKKE 962
Cdd:PRK11281  150 QLVS--------LQTQPERAQAALYAN-------SQRLQQIRNLLKGGKVGGKALRPSQRVLlQAEQALLNAQNDLQRKS 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  963 L---DTIQECIKLKY----APLARLEE---------CERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADL 1026
Cdd:PRK11281  215 LegnTQLQDLLQKQRdyltARIQRLEHqlqllqeaiNSKRLTLSEKTVQEAQSQDEAARIQANPLVAQELEINLQLSQRL 294
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 1125-1320 6.36e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.99  E-value: 6.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1125 RSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQAL 1204
Cdd:COG1579     3 PEDLRALLDLQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1205 KNLET-REVVDMSK----YKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERcdksl 1279
Cdd:COG1579    83 GNVRNnKEYEALQKeiesLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAE----- 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 568962150 1280 ttIMELQQRIQESAKQIEAkdnkitELLNDVERLKQALNGL 1320
Cdd:COG1579   158 --LEELEAEREELAAKIPP------ELLALYERIRKRKNGL 190
46 PHA02562
endonuclease subunit; Provisional
 1115-1317 6.67e-04

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 44.23  E-value: 6.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1115 GTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQknssvtLAEHLKLKEALEKEVGIMKASLREKEEESQKKTKEVSKLQ 1194
Cdd:PHA02562  163 SVLSEMDKLNKDKIRELNQQIQTLDMKIDHIQQQ------IKTYNKNIEEQRKKNGENIARKQNKYDELVEEAKTIKAEI 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1195 TEVQTtkqALKNLetreVVDMSKYKATKNDLETQISNLNDKLASLNRKYD--------QACEEKVSAKDEKEllhlsieQ 1266
Cdd:PHA02562  237 EELTD---ELLNL----VMDIEDPSAALNKLNTAAAKIKSKIEQFQKVIKmyekggvcPTCTQQISEGPDRI-------T 302

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568962150 1267 EIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQAL 1317
Cdd:PHA02562  303 KIKDKLKELQHSLEKLDTAIDELEEIMDEFNEQSKKLLELKNKISTNKQSL 353
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 754-1308 8.90e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 43.89  E-value: 8.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   754 NKKLSEATQRYTEKK-QEAERLLAENDKLTKNVSRLE-AVFVAPEKHEKELMGLKSNIAELKKQLSEL-------NKKCG 824
Cdd:TIGR01612  524 NIIGFDIDQNIKAKLyKEIEAGLKESYELAKNWKKLIhEIKKELEEENEDSIHLEKEIKDLFDKYLEIddeiiyiNKLKL 603

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   825 EGQEKIRALMSENSSLKKTLSSQYV---------------PAKTHEEVKA--SLNSTVEKTNRALLEAKkrFDDTSQEVS 887
Cdd:TIGR01612  604 ELKEKIKNISDKNEYIKKAIDLKKIiennnayidelakisPYQVPEHLKNkdKIYSTIKSELSKIYEDD--IDALYNELS 681

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   888 KLRDENEVlrrnlENVQNQMKadyvsLEEHSRRMSTVSQSLKEAqeanaailadhrqgQEEIVSLH-AEIKAQKKEL-DT 965
Cdd:TIGR01612  682 SIVKENAI-----DNTEDKAK-----LDDLKSKIDKEYDKIQNM--------------ETATVELHlSNIENKKNELlDI 737

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   966 IQECIKLKYAPLAR-LEECERKFKATEKGLKEQLS------EQTHKCRQRDEEVKkgKQENERLRADlaalQKELQDRNA 1038
Cdd:TIGR01612  738 IVEIKKHIHGEINKdLNKILEDFKNKEKELSNKINdyakekDELNKYKSKISEIK--NHYNDQINID----NIKDEDAKQ 811

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1039 LAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLV------EEKAKQASEILAAQNLLQKQPVPLEQVEALKKS 1112
Cdd:TIGR01612  812 NYDKSKEYIKTISIKEDEIFKIINEMKFMKDDFLNKVDKFInfenncKEKIDSEHEQFAELTNKIKAEISDDKLNDYEKK 891

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1113 LNGTIEQLKEELRSkqrcLEREQQTVSQLQ------QLLENQKNSSVTL-AEHLKLKEALEKEVGIMKASlreKEEESQK 1185
Cdd:TIGR01612  892 FNDSKSLINEINKS----IEEEYQNINTLKkvdeyiKICENTKESIEKFhNKQNILKEILNKNIDTIKES---NLIEKSY 964

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1186 KTKEVSKLQTEVQTTKQALKNLEtrevvdMSKYKATKNDLETQISNLNDKLASL--NRKYDQAceekvsakDEKELLHLS 1263
Cdd:TIGR01612  965 KDKFDNTLIDKINELDKAFKDAS------LNDYEAKNNELIKYFNDLKANLGKNkeNMLYHQF--------DEKEKATND 1030

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*.
gi 568962150  1264 IEQEIRDqkerCDKSLTTI-MELQQRIQESAKQIEAKDNKITELLN 1308
Cdd:TIGR01612 1031 IEQKIED----ANKNIPNIeIAIHTSIYNIIDEIEKEIGKNIELLN 1072
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 859-1037 9.22e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.28  E-value: 9.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  859 ASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRMSTV-----SQSLKEAQE 933
Cdd:COG3883    40 DALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALYRSGGSVSYLdvllgSESFSDFLD 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  934 ANAAILADHRQGQEEIvslhAEIKAQKKELDTIQECIKLKyapLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVK 1013
Cdd:COG3883   120 RLSALSKIADADADLL----EELKADKAELEAKKAELEAK---LAELEALKAELEAAKAELEAQQAEQEALLAQLSAEEA 192

                         170       180
                  ....*....|....*....|....
gi 568962150 1014 KGKQENERLRADLAALQKELQDRN 1037
Cdd:COG3883   193 AAEAQLAELEAELAAAEAAAAAAA 216
PRK01156 PRK01156
chromosome segregation protein; Provisional
 707-1259 9.96e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 43.74  E-value: 9.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  707 DVEKLHADNKLLNQQVHSLTVEMKTryvpLRVSEEMKKSHDVNVEDLNKKLSEATQRYTEKKQEAERLLAENDKLTKNVS 786
Cdd:PRK01156  160 EINSLERNYDKLKDVIDMLRAEISN----IDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYN 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  787 RLEAVFVAPEKHEKELMGLKSNIAELKKQLS---ELNKKCGEGQEKIRALMSENSSLKKTLSSQYVPAKTH--------E 855
Cdd:PRK01156  236 NLKSALNELSSLEDMKNRYESEIKTAESDLSmelEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDienkkqilS 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  856 EVKASLN---------STVEKTNRALLEAKKRFDDTSQEVSKLR---DENEVLRRNLENVQNQMKADYVSLEEHSRRMST 923
Cdd:PRK01156  316 NIDAEINkyhaiikklSVLQKDYNDYIKKKSRYDDLNNQILELEgyeMDYNSYLKSIESLKKKIEEYSKNIERMSAFISE 395

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  924 VSQSLKEAQEANAAILADHRQGQEEI----VSLHAEIKAQKKELDTIQECIKL----KYAPLARLEECERKFKATEKGLK 995
Cdd:PRK01156  396 ILKIQEIDPDAIKKELNEINVKLQDIsskvSSLNQRIRALRENLDELSRNMEMlngqSVCPVCGTTLGEEKSNHIINHYN 475

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  996 EQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSER 1075
Cdd:PRK01156  476 EKKSRLEEKIREIEIEVKDIDEKIVDLKKRKEYLESEEINKSINEYNKIESARADLEDIKIKINELKDKHDKYEEIKNRY 555

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1076 EKL----VEEKAKQASEILAAQNLLQKQPVPlEQVEALKKSLNGTIEQLKE---ELRSKQRCLEREQQTVSQLQQLLENQ 1148
Cdd:PRK01156  556 KSLkledLDSKRTSWLNALAVISLIDIETNR-SRSNEIKKQLNDLESRLQEieiGFPDDKSYIDKSIREIENEANNLNNK 634

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1149 KNssvtLAEHLK-LKEALEKEVGIMKASLREKEEeSQKKTKEVSKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLET 1227
Cdd:PRK01156  635 YN----EIQENKiLIEKLRGKIDNYKKQIAEIDS-IIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRT 709

                         570       580       590
                  ....*....|....*....|....*....|..
gi 568962150 1228 QISNLNDKLASLNRKYDQACEEKVSAKDEKEL 1259
Cdd:PRK01156  710 RINELSDRINDINETLESMKKIKKAIGDLKRL 741
PTZ00440 PTZ00440
reticulocyte binding protein 2-like protein; Provisional
 1053-1324 1.02e-03

reticulocyte binding protein 2-like protein; Provisional


Pssm-ID: 240419 [Multi-domain]  Cd Length: 2722  Bit Score: 44.05  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1053 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQAS--EILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRC 1130
Cdd:PTZ00440  451 KINELKKSINQLKTLISIMKSFYDLIISEKDSMDSkeKKESSDSNYQEKVDELLQIINSIKEKNNIVNNNFKNIEDYYIT 530

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1131 LEREQQTVSQLQQLLENQKNSSVTLAEHlklkealEKEVGIMKASLREK---EEESQKKTKEVSKLQTEVQTTKQALKNL 1207
Cdd:PTZ00440  531 IEGLKNEIEGLIELIKYYLQSIETLIKD-------EKLKRSMKNDIKNKikyIEENVDHIKDIISLNDEIDNIIQQIEEL 603

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1208 ETREVVDMSKYKATKNDLETQISNLNDK------------LASLNRKYDQACEEKVSAKDEKELLHLSIEQEIRDQKERC 1275
Cdd:PTZ00440  604 INEALFNKEKFINEKNDLQEKVKYILNKfykgdlqelldeLSHFLDDHKYLYHEAKSKEDLQTLLNTSKNEYEKLEFMKS 683

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 568962150 1276 DKSLTTIMELQqriQESAKQIEAKDNKITELLNDVErlKQALNGLSQLT 1324
Cdd:PTZ00440  684 DNIDNIIKNLK---KELQNLLSLKENIIKKQLNNIE--QDISNSLNQYT 727
PHA02798 PHA02798
ankyrin-like protein; Provisional
 137-213 1.02e-03

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 43.28  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  137 IQLLCDHGASVNAKDIDGRTPL--VLATQ-MCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCR---DAVEVLVKNG 210
Cdd:PHA02798   92 VKILIENGADINKKNSDGETPLycLLSNGyINNLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHHidiEIIKLLLEKG 171


                  ...
gi 568962150  211 ADL 213
Cdd:PHA02798  172 VDI 174
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
759-1243 1.03e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.60  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  759 EATQRYTEKKQEAERLLAENDKLTKNVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELnkkcgegQEKIRALmsens 838
Cdd:COG4717    54 EADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEEL-------REELEKL----- 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  839 slkKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAkkrfddtsQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHS 918
Cdd:COG4717   122 ---EKLLQLLPLYQELEALEAELAELPERLEELEERL--------EELRELEEELEELEAELAELQEELEELLEQLSLAT 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  919 RrmstvsQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQEcIKLKYAPLARLEECERKFKATekGLKEQL 998
Cdd:COG4717   191 E------EELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLEN-ELEAAALEERLKEARLLLLIA--AALLAL 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  999 SEQTHKCRQRDEEVKKGKQENERLRADLAA-LQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREK 1077
Cdd:COG4717   262 LGLGGSLLSLILTIAGVLFLVLGLLALLFLlLAREKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLE 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1078 L---VEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQtVSQLQQLLENQKNSSVT 1154
Cdd:COG4717   342 LldrIEELQELLREAEELEEELQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELKEE-LEELEEQLEELLGELEE 420

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1155 LAEHLKLKEALEKevgimkasLREKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVVDmskykatknDLETQISNLND 1234
Cdd:COG4717   421 LLEALDEEELEEE--------LEELEEELEELEEELEELREELAELEAELEQLEEDGELA---------ELLQELEELKA 483


                  ....*....
gi 568962150 1235 KLASLNRKY 1243
Cdd:COG4717   484 ELRELAEEW 492
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 1052-1260 1.12e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 43.38  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1052 GKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQasEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSkqrcL 1131
Cdd:PRK05771   46 RKLRSLLTKLSEALDKLRSYLPKLNPLREEKKKV--SVKSLEELIKDVEEELEKIEKEIKELEEEISELENEIKE----L 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1132 EREQQTVSQLQQL---LENQKNSSVTLAEHLKLKEALEKEVGImKASLREKEEESQKKTKE-----VSKLQTEVQTT--- 1200
Cdd:PRK05771  120 EQEIERLEPWGNFdldLSLLLGFKYVSVFVGTVPEDKLEELKL-ESDVENVEYISTDKGYVyvvvvVLKELSDEVEEelk 198

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568962150 1201 KQALKNLETREVVD----MSKYKATKNDLETQISNLNDKLASLNRKYDQ---ACEEKVSA-KDEKELL 1260
Cdd:PRK05771  199 KLGFERLELEEEGTpselIREIKEELEEIEKERESLLEELKELAKKYLEellALYEYLEIeLERAEAL 266
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 430-670 1.13e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.39  E-value: 1.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  430 ENEILKKELETLRTYYDSAKQDRLKFQNELAHKVAEckalALECERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQ 509
Cdd:COG1196   261 ELAELEAELEELRLELEELELELEEAQAEEYELLAE----LARLEQDIARLEERRRELEERLEELEEELAELEEELEELE 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  510 THFLALKEHLTNEAAtgshrIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGT 589
Cdd:COG1196   337 EELEELEEELEEAEE-----ELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEA 411

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  590 CEVELERRGRRVVELEGQLKEL-GAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRA 668
Cdd:COG1196   412 LLERLERLEEELEELEEALAELeEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAA 491


                  ..
gi 568962150  669 QH 670
Cdd:COG1196   492 RL 493
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 279-1033 1.13e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 43.50  E-value: 1.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   279 QREQRE-PHSFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLN--EEVMVADDLE------------------SER 337
Cdd:TIGR00606  311 QRTVREkERELVDCQRELEKLNKERRLLNQEKTELLVEQGRLQLQADrhQEHIRARDSLiqslatrleldgfergpfSER 390

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   338 EkLKSLLAAKEKQHEESLRTIEALKNRFK-----------YFESDHPGPGSYPSNRKEDMLHKQGQM--YTTEPQCASPG 404
Cdd:TIGR00606  391 Q-IKNFHTLVIERQEDEAKTAAQLCADLQskerlkqeqadEIRDEKKGLGRTIELKKEILEKKQEELkfVIKELQQLEGS 469

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   405 IPPHMHSRSMLRPLELSLPSQTSYSENEILKKELETLRTYYDSAKQDRLKFQNELAHKVAECKALA--LECERVKEDSDE 482
Cdd:TIGR00606  470 SDRILELDQELRKAERELSKAEKNSLTETLKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTqmEMLTKDKMDKDE 549

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   483 QI-----------------------------------KQLEDALKDVQKRMYESEgkvkQMQTHFLALKEHLTNEAATGS 527
Cdd:TIGR00606  550 QIrkiksrhsdeltsllgyfpnkkqledwlhskskeiNQTRDRLAKLNKELASLE----QNKNHINNELESKEEQLSSYE 625

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   528 HRIIEELREQlkDLKGKYEGASAEVGKLRsqiKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEvelerrgrRVVELEGQ 607
Cdd:TIGR00606  626 DKLFDVCGSQ--DEESDLERLKEEIEKSS---KQRAMLAGATAVYSQFITQLTDENQSCCPVCQ--------RVFQTEAE 692

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   608 LKELGAKL---ALSVPTEkfesmKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIR-PEEHEQLRSRL 683
Cdd:TIGR00606  693 LQEFISDLqskLRLAPDK-----LKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKvNRDIQRLKNDI 767

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   684 EQKSGELGKKVSELTLKnQTLQKDVEKLhadnkllnQQVHSLTVEMKTRYVPLrVSEEMKKSHDVNVEDLNKKLSEATQR 763
Cdd:TIGR00606  768 EEQETLLGTIMPEEESA-KVCLTDVTIM--------ERFQMELKDVERKIAQQ-AAKLQGSDLDRTVQQVNQEKQEKQHE 837

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   764 YTEKKQEAErllaENDKLTknvsrleavfvapEKHEKELMGLKSNIAELKK---QLSELNKKCGEGQEKIRALMSENSSL 840
Cdd:TIGR00606  838 LDTVVSKIE----LNRKLI-------------QDQQEQIQHLKSKTNELKSeklQIGTNLQRRQQFEEQLVELSTEVQSL 900

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   841 KKTLSSQYVPAKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSrr 920
Cdd:TIGR00606  901 IREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDGKDDYLKQKETE-- 978

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   921 MSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKyaplarleECERKFKATEKGLKE-QLS 999
Cdd:TIGR00606  979 LNTVNAQLEECEKHQEKINEDMRLMRQDIDTQKIQERWLQDNLTLRKRENELK--------EVEEELKQHLKEMGQmQVL 1050

                          810       820       830
                   ....*....|....*....|....*....|....
gi 568962150  1000 EQTHKCRQRDEEVKKGKQENERLRADLAALQKEL 1033
Cdd:TIGR00606 1051 QMKQEHQKLEENIDLIKRNHVLALGRQKGYEKEI 1084
Gp58 pfam07902
gp58-like protein; Sequences found in this family are derived from a number of bacteriophage ...
 1056-1345 1.60e-03

gp58-like protein; Sequences found in this family are derived from a number of bacteriophage and prophage proteins. They are similar to gp58, a minor structural protein of Lactococcus delbrueckii bacteriophage LL-H.


Pssm-ID: 369586 [Multi-domain]  Cd Length: 594  Bit Score: 43.02  E-value: 1.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1056 ELSKQLKDL--SQKYSDVKSEREKLVEEKAKQ--ASEIL-AAQNLLQKQPVPLEQVEALkksLNGTIEQLKEELRSKQRC 1130
Cdd:pfam07902   89 ELNLELTDTknSNLWSKIKLNNNGMLREYHNDtiKTEIVeSAEGIATRISEDTDKKLAL---INETISGIRREYQDADRQ 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1131 LERE-QQTVSQLQQLLENQKNssvtlaehlklkeALEKEVGIMKASLrekeeeSQKKTKEVSKLQTEVQTTKQAlknlet 1209
Cdd:pfam07902  166 LSSSyQAGIEGLKATMASDKI-------------GLQAEIQASAQGL------SQRYDNEIRKLSAKITTTSSG------ 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1210 revvdmskykaTKNDLETQISNLNDKLASLNRKYDQACEEKVSA-KDEKELLHLSIEQEIRDQKERCDKSLTTIMELQQR 1288
Cdd:pfam07902  221 -----------TTEAYESKLDDLRAEFTRSNQGMRTELESKISGlQSTQQSTAYQISQEISNREGAVSRVQQDLDSYQRR 289

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568962150  1289 IQESAKQIEAkdnkitellndverLKQALNGL-SQLTYSSGSPTKRQSQLVDTLQQRV 1345
Cdd:pfam07902  290 LQDAEKNYSS--------------LTQTVKGLqSTVSDPNSKLESRITQLAGLIEQKV 333
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 432-1212 1.78e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 42.85  E-value: 1.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   432 EILKKELETLRTYYDSAKQDRLKFQNELAHKVAECKALAleceRVKEDSDEQIKQLEDALKDVQKRMYESEgKVKQMQTH 511
Cdd:pfam01576  359 EELTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQ----QAKQDSEHKRKKLEGQLQELQARLSESE-RQRAELAE 433

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   512 FLAlkeHLTNEaatgshriIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCE 591
Cdd:pfam01576  434 KLS---KLQSE--------LESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQELLQEETRQKLNLSTRLRQLEDERNSLQ 502

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   592 VELERRGRRVVELEGQLKELGAKLAlsvptekfesmksslsndinEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHi 671
Cdd:pfam01576  503 EQLEEEEEAKRNVERQLSTLQAQLS--------------------DMKKKLEEDAGTLEALEEGKKRLQRELEALTQQL- 561

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   672 rpEEHEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQqvhsLTVEMKTryVPLRVSEEMKKSHDVNVE 751
Cdd:pfam01576  562 --EEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQKKFDQ----MLAEEKA--ISARYAEERDRAEAEARE 633

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   752 DLNKKLS--EATQRYTEKKQEAER----LLAENDKLtknVSRLEAVFVAPEKHEKELMGLKSNIAELKKQLSELNKKCGE 825
Cdd:pfam01576  634 KETRALSlaRALEEALEAKEELERtnkqLRAEMEDL---VSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELQA 710

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   826 gqekiralmSENSSLKKTLSSQYVPAK----------THEEVKASLNSTV---------EKTNRAL-LEAKKRFDDTSQE 885
Cdd:pfam01576  711 ---------TEDAKLRLEVNMQALKAQferdlqardeQGEEKRRQLVKQVreleaeledERKQRAQaVAAKKKLELDLKE 781

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   886 -------VSKLRDEnevLRRNLENVQNQMKADYVSLEE-HSRRMSTVSQSlKEAQEANAAILADHRQGQEEIVSLHAEIK 957
Cdd:pfam01576  782 leaqidaANKGREE---AVKQLKKLQAQMKDLQRELEEaRASRDEILAQS-KESEKKLKNLEAELLQLQEDLAASERARR 857

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   958 AQKKELDTIQECIKLKYAPLARLEECERKFKATEKGLKEQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQdrn 1037
Cdd:pfam01576  858 QAQQERDELADEIASGASGKSALQDEKRRLEARIAQLEEELEEEQSNTELLNDRLRKSTLQVEQLTTELAAERSTSQ--- 934

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1038 alaeeareaerALSGKADELSKQLKDLSQKYsdvkSEREKLVEEKAKQASEILAAQnllqkqpvpLEQVEalkkslngti 1117
Cdd:pfam01576  935 -----------KSESARQQLERQNKELKAKL----QEMEGTVKSKFKSSIAALEAK---------IAQLE---------- 980

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1118 EQLKEELRSKQ---RCLEREQQTVSQLQQLLENQKNSSVTLAEHLklkEALEKEVGIMKASLREKEEESQKKTKEVSKLQ 1194
Cdd:pfam01576  981 EQLEQESRERQaanKLVRRTEKKLKEVLLQVEDERRHADQYKDQA---EKGNSRMKQLKRQLEEAEEEASRANAARRKLQ 1057

                          810
                   ....*....|....*...
gi 568962150  1195 TEVQTTKQALKNLeTREV 1212
Cdd:pfam01576 1058 RELDDATESNESM-NREV 1074
CCDC22 pfam05667
Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 ...
 975-1321 1.81e-03

Coiled-coil domain-containing protein 22; Human coiled-coil domain-containing protein 22 (CCDC22) is involved in regulation of NF-kappa-B signalling; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. It is part of the OMMD/CCDC22/CCDC93 (CCC) complex, which interacts with the multisubunit WASH complex required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. This entry also includes CCDC22 homologs from animals and plants.


Pssm-ID: 461708 [Multi-domain]  Cd Length: 600  Bit Score: 42.71  E-value: 1.81e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   975 APLARLEECERKfkATEKGLKEQLSEQTHKCRQRDeevKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKA 1054
Cdd:pfam05667  214 AELAAAQEWEEE--WNSQGLASRLTPEEYRKRKRT---KLLKRIAEQLRSAALAGTEATSGASRSAQDLAELLSSFSGSS 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1055 DELSKQLK----DLSQKYSDVKSEREKLVEEKAKQASEilaaQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELrskqrc 1130
Cdd:pfam05667  289 TTDTGLTKgsrfTHTEKLQFTNEAPAATSSPPTKVETE----EELQQQREEELEELQEQLEDLESSIQELEKEI------ 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1131 lEREQQTVSQLQQLLENQKNSSVTLAEHLKLKEALEKEvgimkasLREKEEEsqkktkeVSKLQTEVQTTKQALKNL--- 1207
Cdd:pfam05667  359 -KKLESSIKQVEEELEELKEQNEELEKQYKVKKKTLDL-------LPDAEEN-------IAKLQALVDASAQRLVELagq 423

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1208 -ETREVVDMSKY---KATKNDLETQISNLNDKLASLNRKYdQACEEKVSAKDE--KELLhlsieqeirDQKERCDKSlTT 1281
Cdd:pfam05667  424 wEKHRVPLIEEYralKEAKSNKEDESQRKLEEIKELREKI-KEVAEEAKQKEElyKQLV---------AEYERLPKD-VS 492

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 568962150  1282 IMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLS 1321
Cdd:pfam05667  493 RSAYTRRILEIVKNIKKQKEEITKILSDTKSLQKEINSLT 532
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 481-1205 1.92e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 42.85  E-value: 1.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   481 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHLT------NEAATGSHRII---EELREQLKDLKGKYEGASAE 551
Cdd:pfam01576   11 EEELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQaetelcAEAEEMRARLAarkQELEEILHELESRLEEEEER 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   552 VGKLRSQIKQSEMLVGEFkrdEGRLVEEN---KRLQKECGTCEVELERRGRRVVELEGQLKELGAKLALSvpTEKFESMK 628
Cdd:pfam01576   91 SQQLQNEKKKMQQHIQDL---EEQLDEEEaarQKLQLEKVTTEAKIKKLEEDILLLEDQNSKLSKERKLL--EERISEFT 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   629 SSLSNDiNEKVKRLAEVGRDYESAQGEIRQLKRDLESVRaqhirpEEHEQLRSRLEQKSGELGKKVSELT-----LKNQT 703
Cdd:pfam01576  166 SNLAEE-EEKAKSLSKLKNKHEAMISDLEERLKKEEKGR------QELEKAKRKLEGESTDLQEQIAELQaqiaeLRAQL 238

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   704 LQKDVEKLHADNKLLNQQVHSLTVEMKTRYVPLRVSEEMkkshdvnvEDLNKKLSEATQRYTEKKQEAERLLAENDKLTK 783
Cdd:pfam01576  239 AKKEEELQAALARLEEETAQKNNALKKIRELEAQISELQ--------EDLESERAARNKAEKQRRDLGEELEALKTELED 310

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   784 NVSRLEAVFVAPEKHEKELMGLKSNIAELKK----QLSELNKKCGEGQEKI------------------RALMSENSSLK 841
Cdd:pfam01576  311 TLDTTAAQQELRSKREQEVTELKKALEEETRsheaQLQEMRQKHTQALEELteqleqakrnkanlekakQALESENAELQ 390

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   842 KTLssqyvpaKTHEEVKASLNSTVEKTNRALLEAKKRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADYVSLEEHSRRM 921
Cdd:pfam01576  391 AEL-------RTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDV 463

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   922 STVSQSLKEAQEanaailadhrQGQEEI---VSLHAEIKAQKKELDTIQEciklkyaplaRLEECERKFKATEK---GLK 995
Cdd:pfam01576  464 SSLESQLQDTQE----------LLQEETrqkLNLSTRLRQLEDERNSLQE----------QLEEEEEAKRNVERqlsTLQ 523

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   996 EQLSEQTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSER 1075
Cdd:pfam01576  524 AQLSDMKKKLEEDAGTLEALEEGKKRLQRELEALTQQLEEKAAAYDKLEKTKNRLQQELDDLLVDLDHQRQLVSNLEKKQ 603

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1076 EK----LVEEKAkqaseiLAAQNLLQKQPVPLEQVEALKKSLNGTIEqLKEELRSKQRCLEREQQTVSQLQQLLENQKNS 1151
Cdd:pfam01576  604 KKfdqmLAEEKA------ISARYAEERDRAEAEAREKETRALSLARA-LEEALEAKEELERTNKQLRAEMEDLVSSKDDV 676

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568962150  1152 SVTLAEHLKLKEALEKEVGIMKASLREKEEESQkkTKEVSKLQTEVqtTKQALK 1205
Cdd:pfam01576  677 GKNVHELERSKRALEQQVEEMKTQLEELEDELQ--ATEDAKLRLEV--NMQALK 726
CagA_N pfam18971
CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial ...
 1017-1295 2.09e-03

CagA protein; The Helicobacter pylori type IV secretion effector CagA is a major bacterial virulence determinant and critical for gastric carcinogenesis. X-ray crystallographic analysis of the N-terminal CagA fragment (residues 1-876) revealed that the region has a structure comprised of three discrete domains. Domain I constitutes a mobile CagA N terminus, while Domain II tethers CagA to the plasma membrane by interacting with membrane phosphatidylserine. Domain III interacts intramolecularly with the intrinsically disordered C-terminal region, and this interaction potentiates the pathogenic scaffold/hub function of CagA.


Pssm-ID: 408741 [Multi-domain]  Cd Length: 876  Bit Score: 42.45  E-value: 2.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1017 QENERLRADLAALQKELQDRnALAEEAREAERALSGKADELSKQLKDLSQ---KYSDVKSEREKLVEEKA--KQASEILA 1091
Cdd:pfam18971  573 QEANKLIKDFLSSNKELAGK-ALNFNKAVAEAKSTGNYDEVKKAQKDLEKslrKREHLEKEVEKKLESKSgnKNKMEAKA 651

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1092 AQNLLQKQPVPLEQVEALKKS----LNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAEH-LKLKEALE 1166
Cdd:pfam18971  652 QANSQKDEIFALINKEANRDAraiaYTQNLKGIKRELSDKLEKISKDLKDFSKSFDEFKNGKNKDFSKAEEtLKALKGSV 731

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1167 KEVGImkaslrekeeesqkKTKEVSKlqteVQTTKQALKNLETREVVDMSKYKATKNDLETQISN------LNDKLASLN 1240
Cdd:pfam18971  732 KDLGI--------------NPEWISK----VENLNAALNEFKNGKNKDFSKVTQAKSDLENSVKDviinqkVTDKVDNLN 793

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 568962150  1241 RKYDQACEEKVSAKDEK---ELLHLSIEQEIRDQKERCDKSLTTIMELQQRIQESAKQ 1295
Cdd:pfam18971  794 QAVSVAKAMGDFSRVEQvlaDLKNFSKEQLAQQAQKNEDFNTGKNSELYQSVKNSVNK 851
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1104-1322 2.26e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 42.31  E-value: 2.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1104 EQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQllenqKNSSVTLAEHLKLkeaLEKEVGIMKASLREKEEES 1183
Cdd:COG3206   164 QNLELRREEARKALEFLEEQLPELRKELEEAEAALEEFRQ-----KNGLVDLSEEAKL---LLQQLSELESQLAEARAEL 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1184 QKKTKEVSKLQTEVQTTKQALKNLETREVVdmSKYKATKNDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLS 1263
Cdd:COG3206   236 AEAEARLAALRAQLGSGPDALPELLQSPVI--QQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQLQQEAQR 313

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568962150 1264 IEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQ 1322
Cdd:COG3206   314 ILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYESLLQ 372
PRK11281 PRK11281
mechanosensitive channel MscK;
1053-1396 2.34e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 42.59  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1053 KADELSKQLKDLSQKYSDVKSEREKLVEEKAKQASEILAAQNL--LQKQpvpLEQVEALKKSLNGTIEQLKEELRSKQRC 1130
Cdd:PRK11281   81 ETEQLKQQLAQAPAKLRQAQAELEALKDDNDEETRETLSTLSLrqLESR---LAQTLDQLQNAQNDLAEYNSQLVSLQTQ 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1131 LEREQQTVS----QLQQ---LLENQKNSSVTLAEHLKLKEALEkevgimKASLREKEEESQKKTKEVSKLQtEVQTTKQA 1203
Cdd:PRK11281  158 PERAQAALYansqRLQQirnLLKGGKVGGKALRPSQRVLLQAE------QALLNAQNDLQRKSLEGNTQLQ-DLLQKQRD 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1204 LKNLETrevvdmskykatkNDLETQISNLNDklaSLNRKYDQACEEKVSakdekellhlsiEQEIRDQKERCDKSLTTIM 1283
Cdd:PRK11281  231 YLTARI-------------QRLEHQLQLLQE---AINSKRLTLSEKTVQ------------EAQSQDEAARIQANPLVAQ 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1284 ELQQRIQESAKQIEAKDnKITELLNDVERLKQALNGLSQltysSGSPTKRQ-SQLVDTL-------QQR--------VRD 1347
Cdd:PRK11281  283 ELEINLQLSQRLLKATE-KLNTLTQQNLRVKNWLDRLTQ----SERNIKEQiSVLKGSLllsrilyQQQqalpsadlIEG 357

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568962150 1348 LQQQLADAdRQHQ-EV---------IAIYRTHLLSAAQGHMDEDVQAALLQIIQMRQGL 1396
Cdd:PRK11281  358 LADRIADL-RLEQfEInqqrdalfqPDAYIDKLEAGHKSEVTDEVRDALLQLLDERREL 415
PRK04778 PRK04778
septation ring formation regulator EzrA; Provisional
 956-1297 2.60e-03

septation ring formation regulator EzrA; Provisional


Pssm-ID: 179877 [Multi-domain]  Cd Length: 569  Bit Score: 42.13  E-value: 2.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  956 IKAqKKELDTIQEciklkyaplaRLEECERKFKATEKGLKEqLSEQTHKCRQRDEEVKKGKQEnerlradlaaLQKELQD 1035
Cdd:PRK04778  101 RKA-KHEINEIES----------LLDLIEEDIEQILEELQE-LLESEEKNREEVEQLKDLYRE----------LRKSLLA 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1036 RNALAeeareaeralsGKA-DELSKQLKDLsqkysdvKSEREKLVEEKAK----QASEILAAQ----NLLQKQpvpLEQV 1106
Cdd:PRK04778  159 NRFSF-----------GPAlDELEKQLENL-------EEEFSQFVELTESgdyvEAREILDQLeeelAALEQI---MEEI 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1107 EALKKSLNGTI-EQLkEELRSKQRCLERE------QQTVSQLQQLLENQKNSSVTLAEhLKLKEALEKEVGIMKA----- 1174
Cdd:PRK04778  218 PELLKELQTELpDQL-QELKAGYRELVEEgyhldhLDIEKEIQDLKEQIDENLALLEE-LDLDEAEEKNEEIQERidqly 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1175 SLREKEEESQKK-TKEVSKLQTEVQTTKQALKNL--ETREVvdMSKYKATKNDLETQiSNLNDKLASLNRKYDQACEEKv 1251
Cdd:PRK04778  296 DILEREVKARKYvEKNSDTLPDFLEHAKEQNKELkeEIDRV--KQSYTLNESELESV-RQLEKQLESLEKQYDEITERI- 371

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 568962150 1252 sakDEKELLHlsieQEIRDQKERCDKSLTTIMELQQRIQESAKQIE 1297
Cdd:PRK04778  372 ---AEQEIAY----SELQEELEEILKQLEEIEKEQEKLSEMLQGLR 410
HOOK pfam05622
HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from ...
 939-1202 2.73e-03

HOOK protein coiled-coil region; This family consists of several HOOK1, 2 and 3 proteins from different eukaryotic organizms. The different members of the human gene family are HOOK1, HOOK2 and HOOK3. Different domains have been identified in the three human HOOK proteins, and it was demonstrated that the highly conserved NH2-domain mediates attachment to microtubules, whereas this central coiled-coil motif mediates homodimerization and the more divergent C-terminal domains are involved in binding to specific organelles (organelle-binding domains). It has been demonstrated that endogenous HOOK3 binds to Golgi membranes, whereas both HOOK1 and HOOK2 are localized to discrete but unidentified cellular structures. In mice the Hook1 gene is predominantly expressed in the testis. Hook1 function is necessary for the correct positioning of microtubular structures within the haploid germ cell. Disruption of Hook1 function in mice causes abnormal sperm head shape and fragile attachment of the flagellum to the sperm head. This entry includes the central coiled-coiled domain and the divergent C-terminal domain.


Pssm-ID: 461694 [Multi-domain]  Cd Length: 528  Bit Score: 41.98  E-value: 2.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   939 LADHRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERK------FKATEKGLKEQLSEQTHKCRQRDEEV 1012
Cdd:pfam05622   96 VLELQHRNEELTSLAEEAQALKDEMDILRESSDKVKKLEATVETYKKKledlgdLRRQVKLLEERNAEYMQRTLQLEEEL 175

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1013 KKGKQenerLRADLAALQKELQDrnalaeeAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAK-------- 1084
Cdd:pfam05622  176 KKANA----LRGQLETYKRQVQE-------LHGKLSEESKKADKLEFEYKKLEEKLEALQKEKERLIIERDTlretneel 244

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1085 -----QASEILAAQNLLQKQPVPLEQV--EALKKSLNGTIEQLKEE---LRSKQRCLEREQQTVsqLQQLLENQKNSSVT 1154
Cdd:pfam05622  245 rcaqlQQAELSQADALLSPSSDPGDNLaaEIMPAEIREKLIRLQHEnkmLRLGQEGSYRERLTE--LQQLLEDANRRKNE 322

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568962150  1155 LAEHLKLKE----------------------------ALEKEVGIMKASLREKEEESQKKTKEVSKLQTEVQTTKQ 1202
Cdd:pfam05622  323 LETQNRLANqrilelqqqveelqkalqeqgskaedssLLKQKLEEHLEKLHEAQSELQKKKEQIEELEPKQDSNLA 398
PHA02946 PHA02946
ankyin-like protein; Provisional
 137-213 2.78e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.96  E-value: 2.78e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568962150  137 IQLLCDHGASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTAL--MLGCEYGCRDAVEVLVKNGADL 213
Cdd:PHA02946   55 VEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQYGAKI 133
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 1078-1306 3.24e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 42.12  E-value: 3.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1078 LVEEKAKQASEILAAQNLLQkqpVPLEQVEALKKSlngtIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTLAE 1157
Cdd:pfam10174  371 LTEEKSTLAGEIRDLKDMLD---VKERKINVLQKK----IENLQEQLRDKDKQLAGLKERVKSLQTDSSNTDTALTTLEE 443

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1158 HLKLK----EALEKEVGIMKASLREKEEESQKKTKE----VSKLQTEVQTTKQAL-------KNLETREVVDMSKYKATK 1222
Cdd:pfam10174  444 ALSEKeriiERLKEQREREDRERLEELESLKKENKDlkekVSALQPELTEKESSLidlkehaSSLASSGLKKDSKLKSLE 523

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1223 NDLETQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLsiEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNK 1302
Cdd:pfam10174  524 IAVEQKKEECSKLENQLKKAHNAEEAVRTNPEINDRIRLL--EQEVARYKEESGKAQAEVERLLGILREVENEKNDKDKK 601


                   ....
gi 568962150  1303 ITEL 1306
Cdd:pfam10174  602 IAEL 605
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 153-181 3.36e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.47  E-value: 3.36e-03
                           10        20
                   ....*....|....*....|....*....
gi 568962150   153 DGRTPLVLATQMCRPTICQLLIDRGADVN 181
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
529-721 3.63e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 41.93  E-value: 3.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  529 RIIEELREQLKDLKGKYEGASAEVGKLRSQiKQSEMLVGEFKRDEGRLVEENKRLQkecgtcEVELERRgrrvvELEGQL 608
Cdd:COG3206   175 KALEFLEEQLPELRKELEEAEAALEEFRQK-NGLVDLSEEAKLLLQQLSELESQLA------EARAELA-----EAEARL 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  609 KELGAKLALS---VPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQhirpeeheqLRSRLEQ 685
Cdd:COG3206   243 AALRAQLGSGpdaLPELLQSPVIQQLRAQLAELEAELAELSARYTPNHPDVIALRAQIAALRAQ---------LQQEAQR 313

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 568962150  686 KSGELGKKVSELTLKNQTLQKDVEKLHADNKLLNQQ 721
Cdd:COG3206   314 ILASLEAELEALQAREASLQAQLAQLEARLAELPEL 349
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1103-1391 3.66e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.98  E-value: 3.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1103 LEQVEALKKSLnGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKNSSVTlaEHLKLKEALEKEVGIMKASLREKEEE 1182
Cdd:TIGR02169  176 LEELEEVEENI-ERLDLIIDEKRQQLERLRREREKAERYQALLKEKREYEGY--ELLKEKEALERQKEAIERQLASLEEE 252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1183 SQKKTKEVSKLQTEVQTTKQALKNLETReVVDMSKYKAtkNDLETQISNLNDKLASLNRKYDQAceekvsakdekellhl 1262
Cdd:TIGR02169  253 LEKLTEEISELEKRLEEIEQLLEELNKK-IKDLGEEEQ--LRVKEKIGELEAEIASLERSIAEK---------------- 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1263 siEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQltyssgsPTKRQSQLVDTLQ 1342
Cdd:TIGR02169  314 --ERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRA-------ELEEVDKEFAETR 384

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 568962150  1343 QRVRDLQQQLADADRQHQEVIAIYRTHLLSAAQGHMD-EDVQAALLQIIQ 1391
Cdd:TIGR02169  385 DELKDYREKLEKLKREINELKRELDRLQEELQRLSEElADLNAAIAGIEA 434
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1083-1344 4.02e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 41.58  E-value: 4.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1083 AKQASEILAAQNLLQ----KQPVPLEQVEALKKSLNGTIEQLKEELRSK--QRCLEREQQTVSQLQQLLENQKNSSVTLA 1156
Cdd:PRK10929   20 ATAPDEKQITQELEQakaaKTPAQAEIVEALQSALNWLEERKGSLERAKqyQQVIDNFPKLSAELRQQLNNERDEPRSVP 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1157 EHLKLKEaLEKEVGIMKASLREKEEESQK---KTKEVS-------KLQTEvqtTKQALKNLETREvvdMSKYKATKNDLE 1226
Cdd:PRK10929  100 PNMSTDA-LEQEILQVSSQLLEKSRQAQQeqdRAREISdslsqlpQQQTE---ARRQLNEIERRL---QTLGTPNTPLAQ 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1227 TQISNLNDKLASLNRKYDQACEEKVSAKDEKELLHLSIEQeIRDQKERCDKSL----TTIMELQQRIQESA--------K 1294
Cdd:PRK10929  173 AQLTALQAESAALKALVDELELAQLSANNRQELARLRSEL-AKKRSQQLDAYLqalrNQLNSQRQREAERAlestellaE 251

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568962150 1295 QIEAKDNKITELLNDVERLKQALNGLSQLTYSSGSptkRQSQLV-DTLQQR 1344
Cdd:PRK10929  252 QSGDLPKSIVAQFKINRELSQALNQQAQRMDLIAS---QQRQAAsQTLQVR 299
Ank_5 pfam13857
Ankyrin repeats (many copies);
142-191 4.16e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.94  E-value: 4.16e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 568962150   142 DHG-ASVNAKDIDGRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTAL 191
Cdd:pfam13857    3 EHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 756-968 4.69e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.97  E-value: 4.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  756 KLSEATQRYTEKKQEAERLLAENDKLTKNVSRLEAvfvapekhekELMGLKSNIAELKKQLSELNKKCGEGQEKIRALMS 835
Cdd:COG3883    17 QIQAKQKELSELQAELEAAQAELDALQAELEELNE----------EYNELQAELEALQAEIDKLQAEIAEAEAEIEERRE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  836 EnssLKKTLSSQYVPAKTHEEVKASLNST--VEKTNRALLEAK--KRFDDTSQEVSKLRDENEVLRRNLENVQNQMKADY 911
Cdd:COG3883    87 E---LGERARALYRSGGSVSYLDVLLGSEsfSDFLDRLSALSKiaDADADLLEELKADKAELEAKKAELEAKLAELEALK 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568962150  912 VSLEEhsrRMSTVSQSLKEAQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQE 968
Cdd:COG3883   164 AELEA---AKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAA 217
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 62-162 4.83e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.42  E-value: 4.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   62 VASKGNLECLNAILTHGIDVATRDSAGRNALHLAAKYGHALCLQKLLQYNCPTEHVDLQGRTALHDAAMADCPSSIQLL- 140
Cdd:PTZ00322   89 LAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLs 168

                          90       100
                  ....*....|....*....|....*...
gi 568962150  141 ----CDHGASVNAK--DIDGRTPLVLAT 162
Cdd:PTZ00322  169 rhsqCHFELGANAKpdSFTGKPPSLEDS 196
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1083-1302 5.15e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 5.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1083 AKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQ-QLLENQKNSSVTLAEHLKL 1161
Cdd:COG4942    16 AAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEqELAALEAELAELEKEIAEL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1162 KEALEKEVGIMKASLREKEEESQKKTKEV---SKLQTEVQTTKQALKNLETREVVDMSKYKATKNDLETQISNLNDKLAS 1238
Cdd:COG4942    96 RAELEAQKEELAELLRALYRLGRQPPLALllsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAE 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568962150 1239 LNRKYDQACEEKV---SAKDEKELLHLSIEQEIRDQKERCDKSLTTIMELQQRIQESAKQIEAKDNK 1302
Cdd:COG4942   176 LEALLAELEEERAaleALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAER 242
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
931-1137 5.23e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.44  E-value: 5.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  931 AQEANAAILADHRQGQEEIVSLHAEIKAQKKELDTIQEciklkyaplaRLEECERkfkatekgLKEQLSEQThKCRQRDE 1010
Cdd:COG4913   608 NRAKLAALEAELAELEEELAEAEERLEALEAELDALQE----------RREALQR--------LAEYSWDEI-DVASAER 668

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1011 EVKKGKQENERLRA---DLAALQKELQDRNALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSEREKLVEEKAKQAS 1087
Cdd:COG4913   669 EIAELEAELERLDAssdDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELR 748

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 568962150 1088 EILAAQNLLQKQPvplEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQT 1137
Cdd:COG4913   749 ALLEERFAAALGD---AVERELRENLEERIDALRARLNRAEEELERAMRA 795
PLN02939 PLN02939
transferase, transferring glycosyl groups
 527-913 5.42e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 41.43  E-value: 5.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  527 SHRIIEEL----REQLKDLKGKYEGASAEVGKLRSQIKQSE---MLVGEFK----RDEGRLVEENKRLQKECGTCEVELE 595
Cdd:PLN02939  101 SMQRDEAIaaidNEQQTNSKDGEQLSDFQLEDLVGMIQNAEkniLLLNQARlqalEDLEKILTEKEALQGKINILEMRLS 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  596 RRGRRVVeLEGQlkelgAKLALSVPTEKFESMKSSLSNDINEKVKRLAEVGRDYESAQGEIRQLKRDLESVRAQHIRPEE 675
Cdd:PLN02939  181 ETDARIK-LAAQ-----EKIHVEILEEQLEKLRNELLIRGATEGLCVHSLSKELDVLKEENMLLKDDIQFLKAELIEVAE 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  676 HEQLRSRLEQKSGELGKKVSELTLKNQTLQKDVEKLhadnkllnqqvhsltvemktryVPLRVSEEMKKshdvnVEDLNK 755
Cdd:PLN02939  255 TEERVFKLEKERSLLDASLRELESKFIVAQEDVSKL----------------------SPLQYDCWWEK-----VENLQD 307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  756 KLSEATQRytekKQEAERLLAENDKLTKNVSRLEAVFVApekhekelmglkSNIAELKKQLSELNkkcgegQEKIRALMS 835
Cdd:PLN02939  308 LLDRATNQ----VEKAALVLDQNQDLRDKVDKLEASLKE------------ANVSKFSSYKVELL------QQKLKLLEE 365

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568962150  836 EnsslkktlsSQYVPAKTHEEVKASLNSTVEktnralleakkrFDDTsqeVSKLRDENEvlRRNLENVQNQMKADYVS 913
Cdd:PLN02939  366 R---------LQASDHEIHSYIQLYQESIKE------------FQDT---LSKLKEESK--KRSLEHPADDMPSEFWS 417
Ank_4 pfam13637
Ankyrin repeats (many copies);
154-207 5.99e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 5.99e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 568962150   154 GRTPLVLATQMCRPTICQLLIDRGADVNSRDKQNRTALMLGCEYGCRDAVEVLV 207
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 280-605 6.50e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.21  E-value: 6.50e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   280 REQREPHSFQDLEIENEDLREKLRKIQQEQRILLDKVNGLQLQLNEEVMVADDLESEREKLKSLLAAKEKQHEESLRTIE 359
Cdd:TIGR02169  675 ELQRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIE 754

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   360 ALKNRFKYFESDHPgpgsypsnRKEDMLHKqgqmyttepqcaspgipphmhsrsmlrpLELSLPSqtsySENEILKKELE 439
Cdd:TIGR02169  755 NVKSELKELEARIE--------ELEEDLHK----------------------------LEEALND----LEARLSHSRIP 794

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   440 TLRTYYDSAKQDRLKFQNELAHKVAECKALALE---CERVKEDSDEQIKQLEDALKDVQKRMYESEGKVKQMQthflalk 516
Cdd:TIGR02169  795 EIQAELSKLEEEVSRIEARLREIEQKLNRLTLEkeyLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELE------- 867

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   517 ehltneaatgshRIIEELREQLKDLKGKYEGASAEVGKLRSQIKQSEMLVGEFKRDEGRLVEENKRLQKECGTCEVELER 596
Cdd:TIGR02169  868 ------------EELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSE 935


                   ....*....
gi 568962150   597 RGRRVVELE 605
Cdd:TIGR02169  936 IEDPKGEDE 944
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 1076-1198 8.42e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 40.58  E-value: 8.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1076 EKLVEEKAKQASEILAAQNLLQkqpvpleQVEALKKSLNGTIEQLKEELRSKQRCLERE-QQTVSQ--------LQQLLE 1146
Cdd:PRK00409  523 ASLEELERELEQKAEEAEALLK-------EAEKLKEELEEKKEKLQEEEDKLLEEAEKEaQQAIKEakkeadeiIKELRQ 595

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568962150 1147 NQKNSSVTLAEHlKLKEALEKevgimkasLREKEEESQKKTKEVSKLQTEVQ 1198
Cdd:PRK00409  596 LQKGGYASVKAH-ELIEARKR--------LNKANEKKEKKKKKQKEKQEELK 638
COG5022 COG5022
Myosin heavy chain [General function prediction only];
1088-1351 8.94e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 40.83  E-value: 8.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1088 EILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQTVSQLQQLLENQKnssvTLAEHLKLKEALEK 1167
Cdd:COG5022   763 RYLQALKRIKKIQVIQHGFRLRRLVDYELKWRLFIKLQPLLSLLGSRKEYRSYLACIIKLQK----TIKREKKLRETEEV 838

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1168 EVGIMKASLREKEEESQKKTKEVSKLQTEV--QTTKQALKNLETR------EVVDMSKYKATKNDLETQISNLND----- 1234
Cdd:COG5022   839 EFSLKAEVLIQKFGRSLKAKKRFSLLKKETiyLQSAQRVELAERQlqelkiDVKSISSLKLVNLELESEIIELKKslssd 918

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150 1235 -------------KLASLNRKYD-------QACEEKVSAKD------------EKELLHLSIEQEIRDQKERCDKS---- 1278
Cdd:COG5022   919 lienlefkteliaRLKKLLNNIDleegpsiEYVKLPELNKLhevesklketseEYEDLLKKSTILVREGNKANSELknfk 998

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568962150 1279 --LTTIMELQQRIQESAKQIEAKDNKITELLNDVERLKQALNGLSQLTYSSGsPTKRQSQLVDTLQQRVRDLQQQ 1351
Cdd:COG5022   999 keLAELSKQYGALQESTKQLKELPVEVAELQSASKIISSESTELSILKPLQK-LKGLLLLENNQLQARYKALKLR 1072
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 926-1394 9.46e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 40.72  E-value: 9.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   926 QSLKEAQEANAAILADhRQGQEEIVSLHAEIKAQKKELDTIQECIKLKYAPLARLEECERK--------FKATEKGLKEQ 997
Cdd:TIGR00618  156 QFLKAKSKEKKELLMN-LFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDtyherkqvLEKELKHLREA 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150   998 LSE--QTHKCRQRDEEVKKGKQENERLRADLAALQKELQDRnALAEEAREAERALSGKADELSKQLKDLSQKYSDVKSER 1075
Cdd:TIGR00618  235 LQQtqQSHAYLTQKREAQEEQLKKQQLLKQLRARIEELRAQ-EAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIH 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1076 EKLVEEKAKQASEILAAQNLLQKQPVPLEQVEALKKSLNGTIEQLKEELRSKQRCLEREQQT-----VSQLQQLLENQKN 1150
Cdd:TIGR00618  314 TELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHtltqhIHTLQQQKTTLTQ 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1151 SSVTLAEHLKLKEALEKEVGIMKASLR---------EKEEESQKKTKEVSKLQTEVQTTKQALKNLETREVvdMSKYKAt 1221
Cdd:TIGR00618  394 KLQSLCKELDILQREQATIDTRTSAFRdlqgqlahaKKQQELQQRYAELCAAAITCTAQCEKLEKIHLQES--AQSLKE- 470

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1222 KNDLETQISNLNDKLASLNRKYDQACEEKVSAKD--EKELLHLSIEQEIRDQKE----RCDKSLTTIMELQQRIQESAKQ 1295
Cdd:TIGR00618  471 REQQLQTKEQIHLQETRKKAVVLARLLELQEEPCplCGSCIHPNPARQDIDNPGpltrRMQRGEQTYAQLETSEEDVYHQ 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962150  1296 IEAKDNKITELLNDVERLKQALNGLSQLTYSSgsptkrqSQLVDTLQQRVRDLQQQLADADRQHQEVIAIYRTHLLSAAQ 1375
Cdd:TIGR00618  551 LTSERKQRASLKEQMQEIQQSFSILTQCDNRS-------KEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQP 623

                          490
                   ....*....|....*....
gi 568962150  1376 GHMDEDVQAALLQIIQMRQ 1394
Cdd:TIGR00618  624 EQDLQDVRLHLQQCSQELA 642
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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