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Conserved domains on  [gi|568960135|ref|XP_006510701|]
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hepatic and glial cell adhesion molecule isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 1-44 1.15e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05740:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 89  Bit Score: 42.38  E-value: 1.15e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 568960135   1 MLLSPDQKVLTITRVLMEDDDLYSCVVENPISQVRSLPVKITVY 44
Cdd:cd05740   46 LTLSNGNRTLTLLNVTREDAGAYQCEISNPVSANRSDPVTLDVI 89
Herpes_UL1 super family cl29975
Herpesvirus glycoprotein L; This family consists of several herpesvirus glycoprotein L or UL1 ...
 132-191 8.56e-03

Herpesvirus glycoprotein L; This family consists of several herpesvirus glycoprotein L or UL1 proteins. Glycoprotein L is known to form a complex with glycoprotein H but the function of this complex is poorly understood.


The actual alignment was detected with superfamily member PHA03301:

Pssm-ID: 392246 [Multi-domain]  Cd Length: 226  Bit Score: 36.39  E-value: 8.56e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568960135 132 DENPATEPRSTTEPGPPGYSVSP-PVPGRSPGLPIRSARRYPRsPARSPATGRTHTSPPRA 191
Cdd:PHA03301 167 TPGPANEPRTRRPLSAPDDEASPqPKSLATPPPVAAPSRRTPR-PRRKPRGNRTRPSRPRN 226
 
Name Accession Description Interval E-value
IgI_hCEACAM_2_4_6_like cd05740
Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion ...
 1-44 1.15e-05

Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains; The members here are composed of the second, fourth, and sixth immunoglobulin (Ig)-like domains in human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) protein subfamily. The CEA family is a group of anchored or secreted glycoproteins expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions; it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface.


Pssm-ID: 409402 [Multi-domain]  Cd Length: 89  Bit Score: 42.38  E-value: 1.15e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 568960135   1 MLLSPDQKVLTITRVLMEDDDLYSCVVENPISQVRSLPVKITVY 44
Cdd:cd05740   46 LTLSNGNRTLTLLNVTREDAGAYQCEISNPVSANRSDPVTLDVI 89
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 4-43 3.59e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.56  E-value: 3.59e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568960135     4 SPDQKVLTITRVLMEDDDLYSCVVENPISQVRSlPVKITV 43
Cdd:smart00410  47 SGSTSTLTISNVTPEDSGTYTCAATNSSGSASS-GTTLTV 85
PHA03301 PHA03301
envelope glycoprotein L; Provisional
 132-191 8.56e-03

envelope glycoprotein L; Provisional


Pssm-ID: 223037 [Multi-domain]  Cd Length: 226  Bit Score: 36.39  E-value: 8.56e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568960135 132 DENPATEPRSTTEPGPPGYSVSP-PVPGRSPGLPIRSARRYPRsPARSPATGRTHTSPPRA 191
Cdd:PHA03301 167 TPGPANEPRTRRPLSAPDDEASPqPKSLATPPPVAAPSRRTPR-PRRKPRGNRTRPSRPRN 226
 
Name Accession Description Interval E-value
IgI_hCEACAM_2_4_6_like cd05740
Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion ...
 1-44 1.15e-05

Immunoglobulin (Ig)-like domain of human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) domains 2, 4, and 6, and similar domains; The members here are composed of the second, fourth, and sixth immunoglobulin (Ig)-like domains in human carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) protein subfamily. The CEA family is a group of anchored or secreted glycoproteins expressed by epithelial cells, leukocytes, endothelial cells, and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions; it is a cell adhesion molecule and a signaling molecule that regulates the growth of tumor cells, an angiogenic factor, and a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface.


Pssm-ID: 409402 [Multi-domain]  Cd Length: 89  Bit Score: 42.38  E-value: 1.15e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 568960135   1 MLLSPDQKVLTITRVLMEDDDLYSCVVENPISQVRSLPVKITVY 44
Cdd:cd05740   46 LTLSNGNRTLTLLNVTREDAGAYQCEISNPVSANRSDPVTLDVI 89
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 4-43 3.59e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 35.56  E-value: 3.59e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568960135     4 SPDQKVLTITRVLMEDDDLYSCVVENPISQVRSlPVKITV 43
Cdd:smart00410  47 SGSTSTLTISNVTPEDSGTYTCAATNSSGSASS-GTTLTV 85
PHA03301 PHA03301
envelope glycoprotein L; Provisional
 132-191 8.56e-03

envelope glycoprotein L; Provisional


Pssm-ID: 223037 [Multi-domain]  Cd Length: 226  Bit Score: 36.39  E-value: 8.56e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568960135 132 DENPATEPRSTTEPGPPGYSVSP-PVPGRSPGLPIRSARRYPRsPARSPATGRTHTSPPRA 191
Cdd:PHA03301 167 TPGPANEPRTRRPLSAPDDEASPqPKSLATPPPVAAPSRRTPR-PRRKPRGNRTRPSRPRN 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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