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Conserved domains on  [gi|568950026|ref|XP_006507601|]
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sulfotransferase 1A1 isoform X1 [Mus musculus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
41-291 1.37e-103

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 302.73  E-value: 1.37e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950026   41 PDDVLISTYPKSGTTWMSEIMDMIYQGGKLDKCGRAPV---YARIPFLEFSCP----GVPPGLETLKETPAPRIIKTHLP 113
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWYPGdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950026  114 LSLLPQSLLDQKIKVIYVARNAKDVVVSYYNFYKMAKLHPDPGTWESFLENFMDGKVSYGSWYQHVKEWWELRRTHPVLY 193
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950026  194 LFYEDMKENPKREIKKILEFLGRSLPEETVDLIVHHTSFKKMKENPMANYTTIPTEVmdhtiSPFMRKGTIGDWKNTFTV 273
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV-----SPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 568950026  274 AQSEHFDAHYAKIMTGCD 291
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
41-291 1.37e-103

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 302.73  E-value: 1.37e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950026   41 PDDVLISTYPKSGTTWMSEIMDMIYQGGKLDKCGRAPV---YARIPFLEFSCP----GVPPGLETLKETPAPRIIKTHLP 113
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWYPGdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950026  114 LSLLPQSLLDQKIKVIYVARNAKDVVVSYYNFYKMAKLHPDPGTWESFLENFMDGKVSYGSWYQHVKEWWELRRTHPVLY 193
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950026  194 LFYEDMKENPKREIKKILEFLGRSLPEETVDLIVHHTSFKKMKENPMANYTTIPTEVmdhtiSPFMRKGTIGDWKNTFTV 273
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV-----SPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 568950026  274 AQSEHFDAHYAKIMTGCD 291
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 37-272 4.65e-21

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 91.52  E-value: 4.65e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950026  37 FTAWPDDVLISTYPKSGTTWMSEIMDMIYQGGKLDKCGRaPVYAR-----IPFLEFSCPGVPPgLETLKETPAPrIIKTH 111
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSN-PLLKRnphefVPYIEIDFPFFPS-VDVLKDKGNT-LFSTH 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950026 112 LPLSLLPQSLLDQKIKVIYVARNAKDVVVSYYNFYKMAKLHPDP-GTWESFLENFMDGKVSYGSWYQHVKEWWELRRTHP 190
Cdd:PLN02164 152 IPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGYWKAYQENP 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950026 191 --VLYLFYEDMKENPKREIKKILEFLGRSLPEE-----TVDLIVHHTSFKKMKeNPMANYTTIPTEVMD--HTISPFMRK 261
Cdd:PLN02164 232 drILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSFETLK-NLEANKGEKDREDRPavYANSAYFRK 310

                        250
                 ....*....|.
gi 568950026 262 GTIGDWKNTFT 272
Cdd:PLN02164 311 GKVGDWQNYLT 321
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
125-249 6.31e-05

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 43.46  E-value: 6.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950026 125 KIKVIYVARNakDVVVSYYNFYKMAKlhpdPGTWESF-LENF-MDGKVSY-----GSWYQHVKEW---WE--LRRT-HPV 191
Cdd:COG4424  103 DLKFIHLTRR--DKLAQAVSLVIAQQ----TGQWHSDaDDALaPTAPPEYdaeeiARLLEALQDFearWEawFARTgITP 176

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568950026 192 LYLFYEDMKENPKREIKKILEFLGRSLPEETVDlivhhTSFKKMKENPMANYTTIPTE 249
Cdd:COG4424  177 LEITYEDLAADPVEVLNRVLDFLGVDPPLAPLR-----PALKKQADEPSDEWVARFRE 229
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
41-291 1.37e-103

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 302.73  E-value: 1.37e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950026   41 PDDVLISTYPKSGTTWMSEIMDMIYQGGKLDKCGRAPV---YARIPFLEFSCP----GVPPGLETLKETPAPRIIKTHLP 113
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWYPGdtyfDVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950026  114 LSLLPQSLLDQKIKVIYVARNAKDVVVSYYNFYKMAKLHPDPGTWESFLENFMDGKVSYGSWYQHVKEWWELRRTHPVLY 193
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950026  194 LFYEDMKENPKREIKKILEFLGRSLPEETVDLIVHHTSFKKMKENPMANYTTIPTEVmdhtiSPFMRKGTIGDWKNTFTV 273
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLPKEV-----SPFFRKGLVGDWKNYFTP 235

                         250
                  ....*....|....*...
gi 568950026  274 AQSEHFDAHYAKIMTGCD 291
Cdd:pfam00685 236 EQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 37-272 4.65e-21

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 91.52  E-value: 4.65e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950026  37 FTAWPDDVLISTYPKSGTTWMSEIMDMIYQGGKLDKCGRaPVYAR-----IPFLEFSCPGVPPgLETLKETPAPrIIKTH 111
Cdd:PLN02164  75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSN-PLLKRnphefVPYIEIDFPFFPS-VDVLKDKGNT-LFSTH 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950026 112 LPLSLLPQSLLDQKIKVIYVARNAKDVVVSYYNFYKMAKLHPDP-GTWESFLENFMDGKVSYGSWYQHVKEWWELRRTHP 190
Cdd:PLN02164 152 IPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGYWKAYQENP 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950026 191 --VLYLFYEDMKENPKREIKKILEFLGRSLPEE-----TVDLIVHHTSFKKMKeNPMANYTTIPTEVMD--HTISPFMRK 261
Cdd:PLN02164 232 drILFLKYETMRADPLPYVKRLAEFMGYGFTAEeeekgVVEKVVKLCSFETLK-NLEANKGEKDREDRPavYANSAYFRK 310

                        250
                 ....*....|.
gi 568950026 262 GTIGDWKNTFT 272
Cdd:PLN02164 311 GKVGDWQNYLT 321
Sulfotransfer_3 pfam13469
Sulfotransferase family;
127-220 5.24e-07

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 48.83  E-value: 5.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950026  127 KVIYVARNAKDVVVSyyNFYKMAKLHPDPgtWESFLENFMDGKVSYgsWYQHVKEWWELRRTHP---VLYLFYEDMKENP 203
Cdd:pfam13469  83 KFIHLHRDPVDTVIS--SYCSLFGFTLSS--YSTAFLRDIGLALAR--WSRAYERLMAARARVPpgrFLDVRYEDLVADP 156

                          90
                  ....*....|....*..
gi 568950026  204 KREIKKILEFLGRSLPE 220
Cdd:pfam13469 157 EGTLRRILEFLGLPWDD 173
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
125-249 6.31e-05

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 43.46  E-value: 6.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568950026 125 KIKVIYVARNakDVVVSYYNFYKMAKlhpdPGTWESF-LENF-MDGKVSY-----GSWYQHVKEW---WE--LRRT-HPV 191
Cdd:COG4424  103 DLKFIHLTRR--DKLAQAVSLVIAQQ----TGQWHSDaDDALaPTAPPEYdaeeiARLLEALQDFearWEawFARTgITP 176

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568950026 192 LYLFYEDMKENPKREIKKILEFLGRSLPEETVDlivhhTSFKKMKENPMANYTTIPTE 249
Cdd:COG4424  177 LEITYEDLAADPVEVLNRVLDFLGVDPPLAPLR-----PALKKQADEPSDEWVARFRE 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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