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Conserved domains on  [gi|568949324|ref|XP_006507261|]
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beta-arrestin-1 isoform X1 [Mus musculus]

Protein Classification

arrestin family protein( domain architecture ID 10448464)

arrestin family protein with both N-terminal and C-terminal Ig-like beta-sandwich domains found in arrestin (S antigen); similar to Homo sapiens beta-arrestin-1 and arrestin domain-containing protein

CATH:  2.60.40.840
Gene Ontology:  GO:0005515
SCOP:  4007521

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
55-211 5.02e-42

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


:

Pssm-ID: 425619  Cd Length: 148  Bit Score: 145.90  E-value: 5.02e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949324   55 LTVYLGKRDFVDHIDlvDPVDGVVLVDPEYLKE-RRVYVTLTCAFRYGREDLDVL--GLTFRKDLFVANVQSFPPAPEDK 131
Cdd:pfam00339   1 FTIEFDKPDGVYFPG--ETVTGRVLLENEEPKKaRAVKIELRGKARTGWEESEVRkeGLTFRKDLYYKGTEVYLPTETSL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949324  132 -KPLTRLQERLIKklGEHACPFTFEIPPNLPCSVtlqpgpedTGKACGVDYEVKAFCAENleEKIHKR-NSVRLVIRKVQ 209
Cdd:pfam00339  79 wGSKTGGQNKLPA--GTHTFPFSFTLPPNCPSSF--------EGKHGGIRYEVKVTLDRP--WKFNKSfRRVFTVIPKLD 146

                  ..
gi 568949324  210 YA 211
Cdd:pfam00339 147 LN 148
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
230-393 3.32e-40

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


:

Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 140.94  E-value: 3.32e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949324   230 SDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTaqYKCPVAMEEADDNVAPSSTFCKVY 309
Cdd:smart01017   1 WSGPLSLEVSLPKKGYVPGETIPVTIKITNLSKKTVKKIKVSLVQTVTYVSSDG--PVKRSLAEKSKEKKADRKTLVKEL 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949324   310 TLTPFLANNREKRglalDGKLKHEDTNLASstllreganREILGIIVSYKVKVKLVVSRGgllgdlaSSDVAVELPFTLM 389
Cdd:smart01017  79 DGGPVLPGNKDKF----EGQLKVPPLPPTS---------RTCRLIKVEYKLKVKLRLSGK-------HSELRLELPITIG 138

                   ....
gi 568949324   390 HPKP 393
Cdd:smart01017 139 TVPL 142
 
Name Accession Description Interval E-value
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
55-211 5.02e-42

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


Pssm-ID: 425619  Cd Length: 148  Bit Score: 145.90  E-value: 5.02e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949324   55 LTVYLGKRDFVDHIDlvDPVDGVVLVDPEYLKE-RRVYVTLTCAFRYGREDLDVL--GLTFRKDLFVANVQSFPPAPEDK 131
Cdd:pfam00339   1 FTIEFDKPDGVYFPG--ETVTGRVLLENEEPKKaRAVKIELRGKARTGWEESEVRkeGLTFRKDLYYKGTEVYLPTETSL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949324  132 -KPLTRLQERLIKklGEHACPFTFEIPPNLPCSVtlqpgpedTGKACGVDYEVKAFCAENleEKIHKR-NSVRLVIRKVQ 209
Cdd:pfam00339  79 wGSKTGGQNKLPA--GTHTFPFSFTLPPNCPSSF--------EGKHGGIRYEVKVTLDRP--WKFNKSfRRVFTVIPKLD 146

                  ..
gi 568949324  210 YA 211
Cdd:pfam00339 147 LN 148
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
230-393 3.32e-40

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 140.94  E-value: 3.32e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949324   230 SDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTaqYKCPVAMEEADDNVAPSSTFCKVY 309
Cdd:smart01017   1 WSGPLSLEVSLPKKGYVPGETIPVTIKITNLSKKTVKKIKVSLVQTVTYVSSDG--PVKRSLAEKSKEKKADRKTLVKEL 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949324   310 TLTPFLANNREKRglalDGKLKHEDTNLASstllreganREILGIIVSYKVKVKLVVSRGgllgdlaSSDVAVELPFTLM 389
Cdd:smart01017  79 DGGPVLPGNKDKF----EGQLKVPPLPPTS---------RTCRLIKVEYKLKVKLRLSGK-------HSELRLELPITIG 138

                   ....
gi 568949324   390 HPKP 393
Cdd:smart01017 139 TVPL 142
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
230-393 1.08e-19

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


Pssm-ID: 460676  Cd Length: 135  Bit Score: 85.07  E-value: 1.08e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949324  230 SDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFN----TAQYKCPVAMEEADDNVAPSS-T 304
Cdd:pfam02752   1 WSGKVSYSVSLPKKGYVPGETIPVTIEIDNQSKKKIKKIKISLVQQLTYKAKTplgeSKREERVVAKEKNPGVAPGSKdK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949324  305 FCKVYTLT-PflannrekrglaldgklkhedTNLASSTllreganREILGIIVSYKVKVKLVVSRGGllgdlasSDVAVE 383
Cdd:pfam02752  81 WEKELQLQiP---------------------TDLPPSS-------TKCKIIKVEYKLKVTVDLSGSA-------SELRLE 125
                         170
                  ....*....|
gi 568949324  384 LPFTLMHPKP 393
Cdd:pfam02752 126 LPITIGTSPL 135
 
Name Accession Description Interval E-value
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
55-211 5.02e-42

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


Pssm-ID: 425619  Cd Length: 148  Bit Score: 145.90  E-value: 5.02e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949324   55 LTVYLGKRDFVDHIDlvDPVDGVVLVDPEYLKE-RRVYVTLTCAFRYGREDLDVL--GLTFRKDLFVANVQSFPPAPEDK 131
Cdd:pfam00339   1 FTIEFDKPDGVYFPG--ETVTGRVLLENEEPKKaRAVKIELRGKARTGWEESEVRkeGLTFRKDLYYKGTEVYLPTETSL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949324  132 -KPLTRLQERLIKklGEHACPFTFEIPPNLPCSVtlqpgpedTGKACGVDYEVKAFCAENleEKIHKR-NSVRLVIRKVQ 209
Cdd:pfam00339  79 wGSKTGGQNKLPA--GTHTFPFSFTLPPNCPSSF--------EGKHGGIRYEVKVTLDRP--WKFNKSfRRVFTVIPKLD 146

                  ..
gi 568949324  210 YA 211
Cdd:pfam00339 147 LN 148
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
230-393 3.32e-40

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 140.94  E-value: 3.32e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949324   230 SDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTaqYKCPVAMEEADDNVAPSSTFCKVY 309
Cdd:smart01017   1 WSGPLSLEVSLPKKGYVPGETIPVTIKITNLSKKTVKKIKVSLVQTVTYVSSDG--PVKRSLAEKSKEKKADRKTLVKEL 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949324   310 TLTPFLANNREKRglalDGKLKHEDTNLASstllreganREILGIIVSYKVKVKLVVSRGgllgdlaSSDVAVELPFTLM 389
Cdd:smart01017  79 DGGPVLPGNKDKF----EGQLKVPPLPPTS---------RTCRLIKVEYKLKVKLRLSGK-------HSELRLELPITIG 138

                   ....
gi 568949324   390 HPKP 393
Cdd:smart01017 139 TVPL 142
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
230-393 1.08e-19

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


Pssm-ID: 460676  Cd Length: 135  Bit Score: 85.07  E-value: 1.08e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949324  230 SDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFN----TAQYKCPVAMEEADDNVAPSS-T 304
Cdd:pfam02752   1 WSGKVSYSVSLPKKGYVPGETIPVTIEIDNQSKKKIKKIKISLVQQLTYKAKTplgeSKREERVVAKEKNPGVAPGSKdK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568949324  305 FCKVYTLT-PflannrekrglaldgklkhedTNLASSTllreganREILGIIVSYKVKVKLVVSRGGllgdlasSDVAVE 383
Cdd:pfam02752  81 WEKELQLQiP---------------------TDLPPSS-------TKCKIIKVEYKLKVTVDLSGSA-------SELRLE 125
                         170
                  ....*....|
gi 568949324  384 LPFTLMHPKP 393
Cdd:pfam02752 126 LPITIGTSPL 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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