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Conserved domains on  [gi|568942708|ref|XP_006506591|]
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protein NDNF isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NDNF_C pfam19433
Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived ...
 394-568 2.47e-108

Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived Neurotrophic Factor (NDNF). NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth of hippocampal neurons. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization. This domain contains the second fibronectin type III domain (FnIII) present in NDNF and one of the two potential consensus sites for N-linked glycosylation.


:

Pssm-ID: 466079  Cd Length: 174  Bit Score: 321.62  E-value: 2.47e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942708  394 RLLLSQNVEGIRQFQLRGKPKGKYLIRLKGNRKGASKLKILATTRPSKHAFPSLPEDTRIKAFDKLRTCSSVTVAWLGTQ 473
Cdd:pfam19433   1 KVLTSESVEGLRHFQLRGKPKAEYLVRLKSGRKGNSSLKVFATTNPHKQPFPSLPEDTKIKVFDKLRTCNSVTVAWLGTQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942708  474 ERRKFCIYRKEVDGNYSEDqKRREQNQCLGPDTRKKSEKVLCKYFHSQNLQKAVTTETIRDLQPGKSYLLDVYVVGHGGH 553
Cdd:pfam19433  81 ERSKYCLYKKEVEEDQVER-ESRKQNRCLGPESRKKSEKVLCKYFHGANLQRAVTTETIEGLEPGTLYLLDVYVIGQGGH 159

                         170
                  ....*....|....*
gi 568942708  554 SVKYQSKIVKTRKVC 568
Cdd:pfam19433 160 SVKYQSKVVKTRKRC 174
NDNF pfam10179
Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the ...
 192-335 8.51e-44

Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the N-terminal of Neuron-derived neurotrophic factor (NDNF) which contains the first fibronectin type III domain and one of the predicted N-linked glycosylation sites. NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization.


:

Pssm-ID: 462981  Cd Length: 127  Bit Score: 151.83  E-value: 8.51e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942708  192 VTLAWKPSPTASiLKQPIEYCVVINKEHNFKSLCAAETKMnaDDAFMvapkPGLDFNPFDFAHFGFPTD-NLGKDRSLLA 270
Cdd:pfam10179   1 VTLKWKPSPSVL-DRHPMHYCLVVNRKHNYKSLCAAVEAI--RKEQP----PGKTSKSFDPASFEFLKErWPQKERKLNP 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568942708  271 KPSpkvgrhvywrpKVDIQKICIGNKNIFTVSDLKPDTQYYFDVFMVNTNTNMSTAYVGAFVRTK 335
Cdd:pfam10179  74 RVS-----------SGDLQIVCVGTKTVQTVSGLKPDTQYYFDVFVVDQLTNTSSAYLGTFAVTF 127
 
Name Accession Description Interval E-value
NDNF_C pfam19433
Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived ...
 394-568 2.47e-108

Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived Neurotrophic Factor (NDNF). NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth of hippocampal neurons. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization. This domain contains the second fibronectin type III domain (FnIII) present in NDNF and one of the two potential consensus sites for N-linked glycosylation.


Pssm-ID: 466079  Cd Length: 174  Bit Score: 321.62  E-value: 2.47e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942708  394 RLLLSQNVEGIRQFQLRGKPKGKYLIRLKGNRKGASKLKILATTRPSKHAFPSLPEDTRIKAFDKLRTCSSVTVAWLGTQ 473
Cdd:pfam19433   1 KVLTSESVEGLRHFQLRGKPKAEYLVRLKSGRKGNSSLKVFATTNPHKQPFPSLPEDTKIKVFDKLRTCNSVTVAWLGTQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942708  474 ERRKFCIYRKEVDGNYSEDqKRREQNQCLGPDTRKKSEKVLCKYFHSQNLQKAVTTETIRDLQPGKSYLLDVYVVGHGGH 553
Cdd:pfam19433  81 ERSKYCLYKKEVEEDQVER-ESRKQNRCLGPESRKKSEKVLCKYFHGANLQRAVTTETIEGLEPGTLYLLDVYVIGQGGH 159

                         170
                  ....*....|....*
gi 568942708  554 SVKYQSKIVKTRKVC 568
Cdd:pfam19433 160 SVKYQSKVVKTRKRC 174
NDNF pfam10179
Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the ...
 192-335 8.51e-44

Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the N-terminal of Neuron-derived neurotrophic factor (NDNF) which contains the first fibronectin type III domain and one of the predicted N-linked glycosylation sites. NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization.


Pssm-ID: 462981  Cd Length: 127  Bit Score: 151.83  E-value: 8.51e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942708  192 VTLAWKPSPTASiLKQPIEYCVVINKEHNFKSLCAAETKMnaDDAFMvapkPGLDFNPFDFAHFGFPTD-NLGKDRSLLA 270
Cdd:pfam10179   1 VTLKWKPSPSVL-DRHPMHYCLVVNRKHNYKSLCAAVEAI--RKEQP----PGKTSKSFDPASFEFLKErWPQKERKLNP 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568942708  271 KPSpkvgrhvywrpKVDIQKICIGNKNIFTVSDLKPDTQYYFDVFMVNTNTNMSTAYVGAFVRTK 335
Cdd:pfam10179  74 RVS-----------SGDLQIVCVGTKTVQTVSGLKPDTQYYFDVFVVDQLTNTSSAYLGTFAVTF 127
 
Name Accession Description Interval E-value
NDNF_C pfam19433
Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived ...
 394-568 2.47e-108

Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived Neurotrophic Factor (NDNF). NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth of hippocampal neurons. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization. This domain contains the second fibronectin type III domain (FnIII) present in NDNF and one of the two potential consensus sites for N-linked glycosylation.


Pssm-ID: 466079  Cd Length: 174  Bit Score: 321.62  E-value: 2.47e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942708  394 RLLLSQNVEGIRQFQLRGKPKGKYLIRLKGNRKGASKLKILATTRPSKHAFPSLPEDTRIKAFDKLRTCSSVTVAWLGTQ 473
Cdd:pfam19433   1 KVLTSESVEGLRHFQLRGKPKAEYLVRLKSGRKGNSSLKVFATTNPHKQPFPSLPEDTKIKVFDKLRTCNSVTVAWLGTQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942708  474 ERRKFCIYRKEVDGNYSEDqKRREQNQCLGPDTRKKSEKVLCKYFHSQNLQKAVTTETIRDLQPGKSYLLDVYVVGHGGH 553
Cdd:pfam19433  81 ERSKYCLYKKEVEEDQVER-ESRKQNRCLGPESRKKSEKVLCKYFHGANLQRAVTTETIEGLEPGTLYLLDVYVIGQGGH 159

                         170
                  ....*....|....*
gi 568942708  554 SVKYQSKIVKTRKVC 568
Cdd:pfam19433 160 SVKYQSKVVKTRKRC 174
NDNF pfam10179
Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the ...
 192-335 8.51e-44

Neuron-derived neurotrophic factor, first Fn(III) domain; This domain is found towards the N-terminal of Neuron-derived neurotrophic factor (NDNF) which contains the first fibronectin type III domain and one of the predicted N-linked glycosylation sites. NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization.


Pssm-ID: 462981  Cd Length: 127  Bit Score: 151.83  E-value: 8.51e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942708  192 VTLAWKPSPTASiLKQPIEYCVVINKEHNFKSLCAAETKMnaDDAFMvapkPGLDFNPFDFAHFGFPTD-NLGKDRSLLA 270
Cdd:pfam10179   1 VTLKWKPSPSVL-DRHPMHYCLVVNRKHNYKSLCAAVEAI--RKEQP----PGKTSKSFDPASFEFLKErWPQKERKLNP 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568942708  271 KPSpkvgrhvywrpKVDIQKICIGNKNIFTVSDLKPDTQYYFDVFMVNTNTNMSTAYVGAFVRTK 335
Cdd:pfam10179  74 RVS-----------SGDLQIVCVGTKTVQTVSGLKPDTQYYFDVFVVDQLTNTSSAYLGTFAVTF 127
NDNF_C pfam19433
Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived ...
 120-335 9.08e-08

Neuron-derived Neurotrophic Factor C-terminal; This is the C-terminal domain of Neuron-derived Neurotrophic Factor (NDNF). NDNF is a glycosylated and disulfide-bonded secreted protein expressed in brain and spinal cord that promotes migration and neurite growth of hippocampal neurons. It also promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization. This domain contains the second fibronectin type III domain (FnIII) present in NDNF and one of the two potential consensus sites for N-linked glycosylation.


Pssm-ID: 466079  Cd Length: 174  Bit Score: 51.98  E-value: 9.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942708  120 VEGTELFSYKGNdveyflssssPSGLYQLELLSTEK-DTHFKVYATTTPeSDQPYPELPYDPRVDVTSFGRT--TVTLAW 196
Cdd:pfam19433   8 VEGLRHFQLRGK----------PKAEYLVRLKSGRKgNSSLKVFATTNP-HKQPFPSLPEDTKIKVFDKLRTcnSVTVAW 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568942708  197 KPSPTASilkqpiEYCVVINKEHnfkslcaaetkmnADDAFMVAPKPGLDFNPfdfahfgfptDNLGKDRSLLAKpspkv 276
Cdd:pfam19433  77 LGTQERS------KYCLYKKEVE-------------EDQVERESRKQNRCLGP----------ESRKKSEKVLCK----- 122

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568942708  277 grhvYWRPKvDIQKICIgnknIFTVSDLKPDTQYYFDVFmVNTNTNMSTAYVGAFVRTK 335
Cdd:pfam19433 123 ----YFHGA-NLQRAVT----TETIEGLEPGTLYLLDVY-VIGQGGHSVKYQSKVVKTR 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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