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Conserved domains on  [gi|568941781|ref|XP_006506145|]
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protein phosphatase Mn(2+)-dependent 1K isoform X1 [Mus musculus]

Protein Classification

PP2C family serine/threonine-protein phosphatase( domain architecture ID 303)

PP2C family protein-serine/threonine phosphatase catalyzes the dephosphorylation of phosphoserine and phosphothreonine residues of specific protein substrates

CATH:  3.60.40.10
EC:  3.1.3.16
Gene Ontology:  GO:0004722
PubMed:  8819174|2549856
SCOP:  3000909

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PP2Cc super family cl00120
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
 95-182 6.25e-17

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


The actual alignment was detected with superfamily member cd00143:

Pssm-ID: 469621 [Multi-domain]  Cd Length: 254  Bit Score: 78.14  E-value: 6.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941781  95 VGCASLIGKRKENEDRFGFA--QLTEEVLYFAVYDGHGGPAAADFCHTHMEKCVMDLLPR-----EKDLETVLTLAFLEI 167
Cdd:cd00143    3 AGVSDKGGDRKTNEDAVVIKpnLNNEDGGLFGVFDGHGGHAAGEFASKLLVEELLEELEEtltlsEEDIEEALRKAFLRA 82

                         90
                 ....*....|....*
gi 568941781 168 DKAFASYAHLSADGK 182
Cdd:cd00143   83 DEEILEEAQDEPDDA 97
 
Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
 95-182 6.25e-17

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 78.14  E-value: 6.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941781  95 VGCASLIGKRKENEDRFGFA--QLTEEVLYFAVYDGHGGPAAADFCHTHMEKCVMDLLPR-----EKDLETVLTLAFLEI 167
Cdd:cd00143    3 AGVSDKGGDRKTNEDAVVIKpnLNNEDGGLFGVFDGHGGHAAGEFASKLLVEELLEELEEtltlsEEDIEEALRKAFLRA 82

                         90
                 ....*....|....*
gi 568941781 168 DKAFASYAHLSADGK 182
Cdd:cd00143   83 DEEILEEAQDEPDDA 97
PP2Cc smart00332
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
 95-171 2.69e-13

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 214625 [Multi-domain]  Cd Length: 252  Bit Score: 67.79  E-value: 2.69e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941781    95 VGCASLIGKRKENEDRFG-FAQLTEEVLYFAVYDGHGGPAAADFCHTHMEKCVMDLLP----REKDLETVLTLAFLEIDK 169
Cdd:smart00332  11 YGLSSMQGVRKPMEDAHViTPDLSDSGGFFGVFDGHGGSEAAKFLSKNLPEILAEELIkekdELEDVEEALRKAFLSTDE 90


                   ..
gi 568941781   170 AF 171
Cdd:smart00332  91 EI 92
PLN03145 PLN03145
Protein phosphatase 2c; Provisional
 96-179 1.25e-07

Protein phosphatase 2c; Provisional


Pssm-ID: 215603 [Multi-domain]  Cd Length: 365  Bit Score: 51.84  E-value: 1.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941781  96 GCASLIGKRKENED----------RFGFAQLTEE-VLYFAVYDGHGGPAAADFCHTHMEKCVMD--LLPREkdLETVLTL 162
Cdd:PLN03145  68 GAWADIGSRSSMEDvyicvdnfmsDFGLKNSEDGpSAFYGVFDGHGGKHAADFACYHLPRFIVEdeDFPRE--IEKVVSS 145

                         90
                 ....*....|....*..
gi 568941781 163 AFLEIDKAFASYAHLSA 179
Cdd:PLN03145 146 AFLQTDTAFAEACSLDA 162
PTC1 COG0631
Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];
94-136 2.36e-04

Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];


Pssm-ID: 440396 [Multi-domain]  Cd Length: 247  Bit Score: 41.35  E-value: 2.36e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 568941781  94 NVGCASLIGK-RKENEDRFGFAQLTEEVLyFAVYDGHGGPAAAD 136
Cdd:COG0631    2 EVAAASDVGRvRENNEDAFLVALDPGGGL-FVVADGMGGHAAGE 44
PP2C pfam00481
Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine ...
 102-175 1.36e-03

Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.


Pssm-ID: 395385  Cd Length: 252  Bit Score: 39.24  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941781  102 GKRKENEDR------FGFAQLTEEVLYFAVYDGHGGPAAADFCHTHMEKC--VMDLLPREKDLETVLTLAFLE-IDKAFA 172
Cdd:pfam00481  10 GWRKSMEDAhidlpnLNSSSGKDSWSFFAVFDGHGGSEAAKYCGKHLHTIlaLRRSFLEGEKLEDALRKSFLEdTDEVLR 89


                  ...
gi 568941781  173 SYA 175
Cdd:pfam00481  90 SAE 92
 
Name Accession Description Interval E-value
PP2Cc cd00143
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
 95-182 6.25e-17

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 238083 [Multi-domain]  Cd Length: 254  Bit Score: 78.14  E-value: 6.25e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941781  95 VGCASLIGKRKENEDRFGFA--QLTEEVLYFAVYDGHGGPAAADFCHTHMEKCVMDLLPR-----EKDLETVLTLAFLEI 167
Cdd:cd00143    3 AGVSDKGGDRKTNEDAVVIKpnLNNEDGGLFGVFDGHGGHAAGEFASKLLVEELLEELEEtltlsEEDIEEALRKAFLRA 82

                         90
                 ....*....|....*
gi 568941781 168 DKAFASYAHLSADGK 182
Cdd:cd00143   83 DEEILEEAQDEPDDA 97
PP2Cc smart00332
Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and ...
 95-171 2.69e-13

Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence similarity.


Pssm-ID: 214625 [Multi-domain]  Cd Length: 252  Bit Score: 67.79  E-value: 2.69e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941781    95 VGCASLIGKRKENEDRFG-FAQLTEEVLYFAVYDGHGGPAAADFCHTHMEKCVMDLLP----REKDLETVLTLAFLEIDK 169
Cdd:smart00332  11 YGLSSMQGVRKPMEDAHViTPDLSDSGGFFGVFDGHGGSEAAKFLSKNLPEILAEELIkekdELEDVEEALRKAFLSTDE 90


                   ..
gi 568941781   170 AF 171
Cdd:smart00332  91 EI 92
PLN03145 PLN03145
Protein phosphatase 2c; Provisional
 96-179 1.25e-07

Protein phosphatase 2c; Provisional


Pssm-ID: 215603 [Multi-domain]  Cd Length: 365  Bit Score: 51.84  E-value: 1.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941781  96 GCASLIGKRKENED----------RFGFAQLTEE-VLYFAVYDGHGGPAAADFCHTHMEKCVMD--LLPREkdLETVLTL 162
Cdd:PLN03145  68 GAWADIGSRSSMEDvyicvdnfmsDFGLKNSEDGpSAFYGVFDGHGGKHAADFACYHLPRFIVEdeDFPRE--IEKVVSS 145

                         90
                 ....*....|....*..
gi 568941781 163 AFLEIDKAFASYAHLSA 179
Cdd:PLN03145 146 AFLQTDTAFAEACSLDA 162
PTC1 COG0631
Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];
94-136 2.36e-04

Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms];


Pssm-ID: 440396 [Multi-domain]  Cd Length: 247  Bit Score: 41.35  E-value: 2.36e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 568941781  94 NVGCASLIGK-RKENEDRFGFAQLTEEVLyFAVYDGHGGPAAAD 136
Cdd:COG0631    2 EVAAASDVGRvRENNEDAFLVALDPGGGL-FVVADGMGGHAAGE 44
PP2C pfam00481
Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine ...
 102-175 1.36e-03

Protein phosphatase 2C; Protein phosphatase 2C is a Mn++ or Mg++ dependent protein serine/threonine phosphatase.


Pssm-ID: 395385  Cd Length: 252  Bit Score: 39.24  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568941781  102 GKRKENEDR------FGFAQLTEEVLYFAVYDGHGGPAAADFCHTHMEKC--VMDLLPREKDLETVLTLAFLE-IDKAFA 172
Cdd:pfam00481  10 GWRKSMEDAhidlpnLNSSSGKDSWSFFAVFDGHGGSEAAKYCGKHLHTIlaLRRSFLEGEKLEDALRKSFLEdTDEVLR 89


                  ...
gi 568941781  173 SYA 175
Cdd:pfam00481  90 SAE 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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