NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568938851|ref|XP_006504830|]
View 

SUN domain-containing protein 1 isoform X19 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MRP pfam09387
Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins ...
 92-288 1.01e-59

Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold.


:

Pssm-ID: 430576  Cd Length: 192  Bit Score: 200.56  E-value: 1.01e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938851   92 SYSSGDSQAIDSHISTSRATPAKGRETRTVKQRRSASKPAFSINHLSGKGLSSStshdsscslrsatvlrhpvldeSLIR 171
Cdd:pfam09387   1 SSAFADGSALDAMNQNRRAQSWRDRAARTQKQRRSASPPAFDIVHWSRKDISSG----------------------SLIR 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938851  172 eQTKVDHFWGLD----DDGDLKGGNKAATQGNGELAAEVASSNGYTCRDCRMLSARtdaLTAHSAIHGTTSRVYSRDRTL 247
Cdd:pfam09387  59 -QTKVDHFWGLDyhlpDDGDLKGGPKAAPQGNGDRAVSVALPNGYTARFCSVLEGR---LTKHEVASGPTNRVFSRDRAQ 134

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568938851  248 K---------------------PRKAASGTFWWLgsgwYQFVTLISWLNVFLLTRCLRNICK 288
Cdd:pfam09387 135 KntytlkctstkpaqgqsqrsnAGKAASEVFEWL----VQFVTLESWLNVFFLTRALRNICG 192
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 650-784 2.04e-57

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


:

Pssm-ID: 400199  Cd Length: 130  Bit Score: 191.73  E-value: 2.04e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938851  650 LWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMKIYPTTFTMEHIPKTLsptgnISSAPKDFAVYGLETEYQEEGQ 729
Cdd:pfam07738   1 LNYEAKPPKVILQPDYMPGPCWSFKGSRGFVVIELSEFIIVEAITLEHVEKSV-----FSSAPKDFEVSGSDRYPTTKWV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568938851  730 PLGRFTYDQEGDSLQMFHTLERPDQAFQIVELRVLSNWGHPEYTCLYRFRVHGEP 784
Cdd:pfam07738  76 LLGEFSYDLDGKTIQTFQLENPPDIWVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
SUN1_cc1 cd21439
coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN ...
 426-479 1.31e-24

coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN domain-containing protein 1 (SUN1), also called protein unc-84 homolog A, or Sad1/unc-84 protein-like 1, is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN1 contains two coiled-coil domains (CC1 and CC2), which act as the intrinsic dynamic regulators for controlling the activity of the SUN domain. This model corresponds to CC1 that may function as an activation segment to release CC2-mediated inhibition of the SUN domain.


:

Pssm-ID: 410605 [Multi-domain]  Cd Length: 55  Bit Score: 96.97  E-value: 1.31e-24
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568938851 426 PDAKTDFMTFHHDHEVRLSNLEDVLRKLTEKSEAIQKELEETKLKAGSRDEEQP 479
Cdd:cd21439    2 PLSQTDFMAFHQEHELRISNLEDLLGKLSEKSEAIQKELEQTKLRTASGADEQQ 55
DR0291 super family cl34310
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 378-520 1.23e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


The actual alignment was detected with superfamily member COG1579:

Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.06  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938851 378 DERLAELTVLLQKLQIRVDQVDDGREGLSlwvknvvgqhlQEMGTIEppDAKTDFMTFHHDHEVRLSNLEDVLRKLTEKS 457
Cdd:COG1579   16 DSELDRLEHRLKELPAELAELEDELAALE-----------ARLEAAK--TELEDLEKEIKRLELEIEEVEARIKKYEEQL 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568938851 458 ---------EAIQKELEETKLKAGSR-DEEQPLLDRVQHLELELNLLKSQLS----DWQHLKTSCEQAGARIQETVQ 520
Cdd:COG1579   83 gnvrnnkeyEALQKEIESLKRRISDLeDEILELMERIEELEEELAELEAELAeleaELEEKKAELDEELAELEAELE 159
HTH_SUN2 super family cl39899
SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, ...
 582-607 1.49e-03

SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, and Syne/Nesprin Homology) and SUN (Sad1 and UNC-84) proteins from the inner and outer nuclear membranes (INM and ONM, respectively). the formation of LINC complexes by KASH and SUN proteins at the nuclear envelope (NE) establishes the physical linkage between the cytoskeleton and nuclear lamina, which is instrumental for the mechanical force transmission from the cytoplasm to the nuclear interior, and is essential for cellular processes such as nuclear positioning and migration, centrosome-nucleus anchorage, and chromosome dynamics. This entry represents an HTH domain found in SUN2 that forms a three-helix bundle to lock the SUN domain in an inactive conformation acting as an inhibitory component.


The actual alignment was detected with superfamily member pfam18580:

Pssm-ID: 436594 [Multi-domain]  Cd Length: 58  Bit Score: 37.31  E-value: 1.49e-03
                          10        20
                  ....*....|....*....|....*.
gi 568938851  582 SAVNQAGISGITEAQAHIIVNNALKL 607
Cdd:pfam18580  33 VALQQEGVTGVTEEQVHRIVNQALKR 58
 
Name Accession Description Interval E-value
MRP pfam09387
Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins ...
 92-288 1.01e-59

Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold.


Pssm-ID: 430576  Cd Length: 192  Bit Score: 200.56  E-value: 1.01e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938851   92 SYSSGDSQAIDSHISTSRATPAKGRETRTVKQRRSASKPAFSINHLSGKGLSSStshdsscslrsatvlrhpvldeSLIR 171
Cdd:pfam09387   1 SSAFADGSALDAMNQNRRAQSWRDRAARTQKQRRSASPPAFDIVHWSRKDISSG----------------------SLIR 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938851  172 eQTKVDHFWGLD----DDGDLKGGNKAATQGNGELAAEVASSNGYTCRDCRMLSARtdaLTAHSAIHGTTSRVYSRDRTL 247
Cdd:pfam09387  59 -QTKVDHFWGLDyhlpDDGDLKGGPKAAPQGNGDRAVSVALPNGYTARFCSVLEGR---LTKHEVASGPTNRVFSRDRAQ 134

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568938851  248 K---------------------PRKAASGTFWWLgsgwYQFVTLISWLNVFLLTRCLRNICK 288
Cdd:pfam09387 135 KntytlkctstkpaqgqsqrsnAGKAASEVFEWL----VQFVTLESWLNVFFLTRALRNICG 192
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 650-784 2.04e-57

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


Pssm-ID: 400199  Cd Length: 130  Bit Score: 191.73  E-value: 2.04e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938851  650 LWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMKIYPTTFTMEHIPKTLsptgnISSAPKDFAVYGLETEYQEEGQ 729
Cdd:pfam07738   1 LNYEAKPPKVILQPDYMPGPCWSFKGSRGFVVIELSEFIIVEAITLEHVEKSV-----FSSAPKDFEVSGSDRYPTTKWV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568938851  730 PLGRFTYDQEGDSLQMFHTLERPDQAFQIVELRVLSNWGHPEYTCLYRFRVHGEP 784
Cdd:pfam07738  76 LLGEFSYDLDGKTIQTFQLENPPDIWVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
SUN1_cc1 cd21439
coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN ...
 426-479 1.31e-24

coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN domain-containing protein 1 (SUN1), also called protein unc-84 homolog A, or Sad1/unc-84 protein-like 1, is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN1 contains two coiled-coil domains (CC1 and CC2), which act as the intrinsic dynamic regulators for controlling the activity of the SUN domain. This model corresponds to CC1 that may function as an activation segment to release CC2-mediated inhibition of the SUN domain.


Pssm-ID: 410605 [Multi-domain]  Cd Length: 55  Bit Score: 96.97  E-value: 1.31e-24
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568938851 426 PDAKTDFMTFHHDHEVRLSNLEDVLRKLTEKSEAIQKELEETKLKAGSRDEEQP 479
Cdd:cd21439    2 PLSQTDFMAFHQEHELRISNLEDLLGKLSEKSEAIQKELEQTKLRTASGADEQQ 55
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 378-520 1.23e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.06  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938851 378 DERLAELTVLLQKLQIRVDQVDDGREGLSlwvknvvgqhlQEMGTIEppDAKTDFMTFHHDHEVRLSNLEDVLRKLTEKS 457
Cdd:COG1579   16 DSELDRLEHRLKELPAELAELEDELAALE-----------ARLEAAK--TELEDLEKEIKRLELEIEEVEARIKKYEEQL 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568938851 458 ---------EAIQKELEETKLKAGSR-DEEQPLLDRVQHLELELNLLKSQLS----DWQHLKTSCEQAGARIQETVQ 520
Cdd:COG1579   83 gnvrnnkeyEALQKEIESLKRRISDLeDEILELMERIEELEEELAELEAELAeleaELEEKKAELDEELAELEAELE 159
HTH_SUN2 pfam18580
SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, ...
 582-607 1.49e-03

SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, and Syne/Nesprin Homology) and SUN (Sad1 and UNC-84) proteins from the inner and outer nuclear membranes (INM and ONM, respectively). the formation of LINC complexes by KASH and SUN proteins at the nuclear envelope (NE) establishes the physical linkage between the cytoskeleton and nuclear lamina, which is instrumental for the mechanical force transmission from the cytoplasm to the nuclear interior, and is essential for cellular processes such as nuclear positioning and migration, centrosome-nucleus anchorage, and chromosome dynamics. This entry represents an HTH domain found in SUN2 that forms a three-helix bundle to lock the SUN domain in an inactive conformation acting as an inhibitory component.


Pssm-ID: 436594 [Multi-domain]  Cd Length: 58  Bit Score: 37.31  E-value: 1.49e-03
                          10        20
                  ....*....|....*....|....*.
gi 568938851  582 SAVNQAGISGITEAQAHIIVNNALKL 607
Cdd:pfam18580  33 VALQQEGVTGVTEEQVHRIVNQALKR 58
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 378-541 1.79e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 41.80  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938851  378 DERLAELTVLLQKLQIRVDQVDDGREGLSLWVKNVvgQHLQEMGTIEppdaKTDFMTFHHDHEVRLSNLEDVLRKLTEKS 457
Cdd:pfam07888  72 ERQRRELESRVAELKEELRQSREKHEELEEKYKEL--SASSEELSEE----KDALLAQRAAHEARIRELEEDIKTLTQRV 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938851  458 EAIQKELEETKLKA----GSRDEEQPLLDRVQ-HLELELNLLKSQLSDWQHLKTSCEQAGA---RIQETV----QLMFSE 525
Cdd:pfam07888 146 LERETELERMKERAkkagAQRKEEEAERKQLQaKLQQTEEELRSLSKEFQELRNSLAQRDTqvlQLQDTIttltQKLTTA 225

                         170
                  ....*....|....*.
gi 568938851  526 DQQGGSLEWLLEKLSS 541
Cdd:pfam07888 226 HRKEAENEALLEELRS 241
 
Name Accession Description Interval E-value
MRP pfam09387
Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins ...
 92-288 1.01e-59

Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold.


Pssm-ID: 430576  Cd Length: 192  Bit Score: 200.56  E-value: 1.01e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938851   92 SYSSGDSQAIDSHISTSRATPAKGRETRTVKQRRSASKPAFSINHLSGKGLSSStshdsscslrsatvlrhpvldeSLIR 171
Cdd:pfam09387   1 SSAFADGSALDAMNQNRRAQSWRDRAARTQKQRRSASPPAFDIVHWSRKDISSG----------------------SLIR 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938851  172 eQTKVDHFWGLD----DDGDLKGGNKAATQGNGELAAEVASSNGYTCRDCRMLSARtdaLTAHSAIHGTTSRVYSRDRTL 247
Cdd:pfam09387  59 -QTKVDHFWGLDyhlpDDGDLKGGPKAAPQGNGDRAVSVALPNGYTARFCSVLEGR---LTKHEVASGPTNRVFSRDRAQ 134

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568938851  248 K---------------------PRKAASGTFWWLgsgwYQFVTLISWLNVFLLTRCLRNICK 288
Cdd:pfam09387 135 KntytlkctstkpaqgqsqrsnAGKAASEVFEWL----VQFVTLESWLNVFFLTRALRNICG 192
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 650-784 2.04e-57

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


Pssm-ID: 400199  Cd Length: 130  Bit Score: 191.73  E-value: 2.04e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938851  650 LWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMKIYPTTFTMEHIPKTLsptgnISSAPKDFAVYGLETEYQEEGQ 729
Cdd:pfam07738   1 LNYEAKPPKVILQPDYMPGPCWSFKGSRGFVVIELSEFIIVEAITLEHVEKSV-----FSSAPKDFEVSGSDRYPTTKWV 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568938851  730 PLGRFTYDQEGDSLQMFHTLERPDQAFQIVELRVLSNWGHPEYTCLYRFRVHGEP 784
Cdd:pfam07738  76 LLGEFSYDLDGKTIQTFQLENPPDIWVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
SUN1_cc1 cd21439
coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN ...
 426-479 1.31e-24

coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN domain-containing protein 1 (SUN1), also called protein unc-84 homolog A, or Sad1/unc-84 protein-like 1, is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN1 contains two coiled-coil domains (CC1 and CC2), which act as the intrinsic dynamic regulators for controlling the activity of the SUN domain. This model corresponds to CC1 that may function as an activation segment to release CC2-mediated inhibition of the SUN domain.


Pssm-ID: 410605 [Multi-domain]  Cd Length: 55  Bit Score: 96.97  E-value: 1.31e-24
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568938851 426 PDAKTDFMTFHHDHEVRLSNLEDVLRKLTEKSEAIQKELEETKLKAGSRDEEQP 479
Cdd:cd21439    2 PLSQTDFMAFHQEHELRISNLEDLLGKLSEKSEAIQKELEQTKLRTASGADEQQ 55
SUN_cc1 cd21435
coiled-coil domain 1 of SUN domain-containing proteins; SUN (Sad1 and UNC-84) proteins (SUN1 ...
 429-478 1.60e-11

coiled-coil domain 1 of SUN domain-containing proteins; SUN (Sad1 and UNC-84) proteins (SUN1 and SUN2) are components of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN proteins contain two coiled-coil domains (CC1 and CC2), which act as intrinsic dynamic regulators controlling the activity of the SUN domain. The model corresponds to CC1 that functions as an activation segment to release CC2-mediated inhibition of the SUN domain.


Pssm-ID: 410603 [Multi-domain]  Cd Length: 55  Bit Score: 59.73  E-value: 1.60e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 568938851 429 KTDFMTFHHDHEVRLSNLEDVLRKLTEKSEAIQKELEETKLKAGSRDEEQ 478
Cdd:cd21435    5 QESSVKELGRLEAQLASLRQELAALTLKQEAIQKELEQTKQKTISAVGEQ 54
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 378-520 1.23e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.06  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938851 378 DERLAELTVLLQKLQIRVDQVDDGREGLSlwvknvvgqhlQEMGTIEppDAKTDFMTFHHDHEVRLSNLEDVLRKLTEKS 457
Cdd:COG1579   16 DSELDRLEHRLKELPAELAELEDELAALE-----------ARLEAAK--TELEDLEKEIKRLELEIEEVEARIKKYEEQL 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568938851 458 ---------EAIQKELEETKLKAGSR-DEEQPLLDRVQHLELELNLLKSQLS----DWQHLKTSCEQAGARIQETVQ 520
Cdd:COG1579   83 gnvrnnkeyEALQKEIESLKRRISDLeDEILELMERIEELEEELAELEAELAeleaELEEKKAELDEELAELEAELE 159
HTH_SUN2 pfam18580
SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, ...
 582-607 1.49e-03

SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, and Syne/Nesprin Homology) and SUN (Sad1 and UNC-84) proteins from the inner and outer nuclear membranes (INM and ONM, respectively). the formation of LINC complexes by KASH and SUN proteins at the nuclear envelope (NE) establishes the physical linkage between the cytoskeleton and nuclear lamina, which is instrumental for the mechanical force transmission from the cytoplasm to the nuclear interior, and is essential for cellular processes such as nuclear positioning and migration, centrosome-nucleus anchorage, and chromosome dynamics. This entry represents an HTH domain found in SUN2 that forms a three-helix bundle to lock the SUN domain in an inactive conformation acting as an inhibitory component.


Pssm-ID: 436594 [Multi-domain]  Cd Length: 58  Bit Score: 37.31  E-value: 1.49e-03
                          10        20
                  ....*....|....*....|....*.
gi 568938851  582 SAVNQAGISGITEAQAHIIVNNALKL 607
Cdd:pfam18580  33 VALQQEGVTGVTEEQVHRIVNQALKR 58
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 378-541 1.79e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 41.80  E-value: 1.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938851  378 DERLAELTVLLQKLQIRVDQVDDGREGLSLWVKNVvgQHLQEMGTIEppdaKTDFMTFHHDHEVRLSNLEDVLRKLTEKS 457
Cdd:pfam07888  72 ERQRRELESRVAELKEELRQSREKHEELEEKYKEL--SASSEELSEE----KDALLAQRAAHEARIRELEEDIKTLTQRV 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568938851  458 EAIQKELEETKLKA----GSRDEEQPLLDRVQ-HLELELNLLKSQLSDWQHLKTSCEQAGA---RIQETV----QLMFSE 525
Cdd:pfam07888 146 LERETELERMKERAkkagAQRKEEEAERKQLQaKLQQTEEELRSLSKEFQELRNSLAQRDTqvlQLQDTIttltQKLTTA 225

                         170
                  ....*....|....*.
gi 568938851  526 DQQGGSLEWLLEKLSS 541
Cdd:pfam07888 226 HRKEAENEALLEELRS 241
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH